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https://www.readbyqxmd.com/read/29454178/caffeine-use-disorder-an-item-response-theory-analysis-of-proposed-dsm-5-criteria
#1
Csilla Ágoston, Róbert Urbán, Mara J Richman, Zsolt Demetrovics
INTRODUCTION: Caffeine is a common psychoactive substance with a documented addictive potential. Caffeine withdrawal has been included in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), but caffeine use disorder (CUD) is considered to be a condition for further study. The aim of the current study is (1) to test the psychometric properties of the Caffeine Use Disorder Questionnaire (CUDQ) by using a confirmatory factor analysis and an item response theory (IRT) approach, (2) to compare IRT models with varying numbers of parameters and models with or without caffeine consumption criteria, and (3) to examine if the total daily caffeine consumption and the use of different caffeinated products can predict the magnitude of CUD symptomatology...
February 9, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29454121/complications-of-impulse-generator-exchange-surgery-for-deep-brain-stimulation-a-single-centre-retrospective-study
#2
Ann-Kristin Helmers, Isabel Lübbing, Falk Birkenfeld, Karsten Witt, Michael Synowitz, Hubertus Maximilian Mehdorn, Daniela Falk
OBJECTIVE: Non-rechargeable deep brain stimulation (DBS) impulse generators (IG) with a low or empty battery status require surgical IG exchange several years after initial implantation. Complication rates in patients undergoing DBS surgery range from 7.6% to 25.3%. The aim of this study was to investigate the complication rates after IG exchange surgery and to identify risk factors for complications. METHODS: We retrospectively analysed complications following IG exchange surgery from 2008 to 2015 in a single-centre university hospital setting...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29453857/psychosocial-student-functioning-in-comprehensive-dental-clinic-education-a-qualitative-study
#3
R Moore
INTRODUCTION: The aims were to describe first-year clinical dental students' psychosocial experiences in a known well-functioning comprehensive clinic teaching group (F+Grp) and a known dysfunctional group (Dys-Grp) and, thus, discover and describe phenomena related to psychosocial functioning of students. These groups were compared and contrasted regarding negative stress symptoms, perfectionism and coping with stress. METHODS: Eight female dental students (mean 26 years old), four in each group, were interviewed after the first clinical year about learning and emotional experiences...
February 17, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29453456/loss-of-microrna-128-promotes-cardiomyocyte-proliferation-and-heart-regeneration
#4
Wei Huang, Yuliang Feng, Jialiang Liang, Hao Yu, Cheng Wang, Boyu Wang, Mingyang Wang, Lin Jiang, Wei Meng, Wenfeng Cai, Mario Medvedovic, Jenny Chen, Christian Paul, W Sean Davidson, Sakthivel Sadayappan, Peter J Stambrook, Xi-Yong Yu, Yigang Wang
The goal of replenishing the cardiomyocyte (CM) population using regenerative therapies following myocardial infarction (MI) is hampered by the limited regeneration capacity of adult CMs, partially due to their withdrawal from the cell cycle. Here, we show that microRNA-128 (miR-128) is upregulated in CMs during the postnatal switch from proliferation to terminal differentiation. In neonatal mice, cardiac-specific overexpression of miR-128 impairs CM proliferation and cardiac function, while miR-128 deletion extends proliferation of postnatal CMs by enhancing expression of the chromatin modifier SUZ12, which suppresses p27 (cyclin-dependent kinase inhibitor) expression and activates the positive cell cycle regulators Cyclin E and CDK2...
February 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29453217/time-spent-in-inactive-disease-before-mtx-withdrawal-is-relevant-with-regard-to-the-flare-risk-in-patients-with-jia
#5
Jens Klotsche, Kirsten Minden, Martina Niewerth, Gerd Horneff
OBJECTIVES: To determine the reasons of methotrexate (MTX) discontinuation, frequency of adverse events (AE) and whether the time in inactive disease before MTX withdrawal disease is associated with the risk of disease flare. METHODS: Patients with juvenile idiopathic arthritis (JIA) beginning treatment with MTX were prospectively observed in the national JIA biologic register Biologika in der Kinderrheumatologie/Biologics in Paediatric Rheumatology and its follow-up register Juvenile arthritis Methotrexate/Biologics long-term Observation...
February 16, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29453116/developing-a-methodology-for-real-time-trading-of-water-withdrawal-and-waste-load-discharge-permits-in-rivers
#6
Maryam Soltani, Reza Kerachian
In this paper, a new methodology is proposed for the real-time trading of water withdrawal and waste load discharge permits in agricultural areas along the rivers. Total Dissolved Solids (TDS) is chosen as an indicator of river water quality and the TDS load that agricultural water users discharge to the river are controlled by storing a part of return flows in some evaporation ponds. Available surface water withdrawal and waste load discharge permits are determined using a non-linear multi-objective optimization model...
February 13, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29452722/traumatic-lingual-hematoma-resulting-in-bilateral-temporal-mandibular-joint-dislocations
#7
Dhara P Amin, Michael N Cooper, Kim I Newton
BACKGROUND: Lingual hematoma (LH) is a relatively uncommon entity seen after both medical and traumatic etiologies. Regardless of the cause, the feared complication is acute airway obstruction. CASE REPORT: Our case involves a 39-year-old man who presented to the Emergency Department via emergency medical services with an enlarging LH after an unwitnessed fall, suspected to be an alcohol withdrawal seizure. The bleeding was likely exacerbated by previously undiagnosed thrombocytopenia...
February 13, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29452600/patterns-of-paediatric-end-of-life-care-a-chart-review-across-different-care-settings-in-switzerland
#8
Karin Zimmermann, Eva Cignacco, Sandra Engberg, Anne-Sylvie Ramelet, Nicolas von der Weid, Katri Eskola, Eva Bergstraesser, Marc Ansari, Christoph Aebi, Reta Baer, Maja Beck Popovic, Vera Bernet, Pierluigi Brazzola, Hans Ulrich Bucher, Regula Buder, Sandra Cagnazzo, Barbara Dinten, Anouk Dorsaz, Franz Elmer, Raquel Enriquez, Patricia Fahrni-Nater, Gabi Finkbeiner, Bernhard Frey, Urs Frey, Jeannette Greiner, Ralph-Ingo Hassink, Simone Keller, Oliver Kretschmar, Judith Kroell, Bernard Laubscher, Kurt Leibundgut, Reta Malaer, Andreas Meyer, Christoph Stuessi, Mathias Nelle, Thomas Neuhaus, Felix Niggli, Geneviève Perrenoud, Jean-Pierre Pfammatter, Barbara Plecko, Debora Rupf, Felix Sennhauser, Caroline Stade, Maja Steinlin, Lilian Stoffel, Karin Thomas, Christian Vonarburg, Rodo von Vigier, Bendicht Wagner, Judith Wieland, Birgit Wernz
BACKGROUND: Paediatric end-of-life care is challenging and requires a high level of professional expertise. It is important that healthcare teams have a thorough understanding of paediatric subspecialties and related knowledge of disease-specific aspects of paediatric end-of-life care. The aim of this study was to comprehensively describe, explore and compare current practices in paediatric end-of-life care in four distinct diagnostic groups across healthcare settings including all relevant levels of healthcare providers in Switzerland...
February 16, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29452427/effect-of-routine-screening-head-ultrasounds-on-clinical-interventions-for-premature-infants
#9
Andrew Z Heling, Matthew M Laughon, Wayne A Price
OBJECTIVE: This article assesses whether routine, screening head ultrasound (HUS) studies performed at 7 to 14 postnatal days for premature infants are followed by clinical interventions. STUDY DESIGN: This retrospective cohort study included all inborn infants delivered at < 30 weeks' gestational age (GA) between January 1, 2012 and December 31, 2015 at a single center who had a routine, screening HUS performed between 7 and 14 postnatal days ( n = 303). We defined "clinical intervention" as a 7 to 14 postnatal day HUS that was followed by neurosurgical intervention prior to a 36- to 40-week postmenstrual age (PMA) HUS or elective withdrawal of critical care within 30 days of a positive HUS finding...
February 16, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29452407/dietary-l-glutamine-supplementation-improves-growth-performance-gut-morphology-and-serum-biochemical-indices-of-broiler-chickens-during-necrotic-enteritis-challenge
#10
G D Xue, R Barekatain, S B Wu, M Choct, R A Swick
Necrotic enteritis (NE) causes significant economic losses in the broiler chicken industry, especially in birds raised without in-feed antibiotics. L-glutamine (Gln) is an amino acid that may compensate for metabolic losses from infection and improve the intestinal development. This study investigated the effects of dietary Gln (10 g/kg) supplementation on growth performance, intestinal lesions, jejunum morphology, and serum biochemical indices of broiler chickens during NE challenge. The study employed a factorial arrangement of treatments with factors: NE challenge, no or yes; dietary Gln inclusion, 0 g/kg in starter (S), d 0 to 10, grower (G) d 10 to 24, and finisher (F) d 24 to 35; 10 g/kg in S, G, F, or 10 g/kg in S, G only...
February 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29452180/the-m-maze-task-an-automated-method-for-studying-fear-memory-in-rats-exposed-to-protracted-aversive-conditioning
#11
Rimenez R Souza, Nicole M Robertson, David T Pruitt, Lindsey Noble, Eric C Meyers, Phillip A Gonzales, Nathaniel P Bleker, Holle L Carey, Seth A Hays, Michael P Kilgard, Christa K McIntyre, Robert L Rennaker
BACKGROUND: Fear conditioning (FC) in rodents is the most used animal model to investigate the neurobiology of posttraumatic stress disorder (PTSD). Although research using FC has generated a better understanding of fear memories, studies often rely on mild or moderate FC training and behavioral analysis generally focuses on measuring freezing responses within few test sessions. NEW METHOD: We introduce the M-Maze task, a system to measures extinction of conditioned fear using suppression of operant behavior...
February 13, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29450305/the-grimace-scale-reliably-assesses-chronic-pain-in-a-rodent-model-of-trigeminal-neuropathic-pain
#12
Titilola Akintola, Charles Raver, Paige Studlack, Olivia Uddin, Radi Masri, Asaf Keller
The limited success in translating basic science findings into effective pain management therapies reflects, in part, the difficulty in reliably assessing pain in experimental animals. This shortcoming is particularly acute in the field of chronic, ongoing pain. Quantitative analysis of facial expressions-the grimace score-was introduced as a promising tool, however, it is thought to reliably assess only pain of short or medium duration (minutes to hours). Here, we test the hypothesis that grimace scores are a reliable metric of ongoing neuropathic pain, by testing the prediction that chronic constriction injury of the infraorbital nerve (CCI-ION) will evoke significant increases in grimace scale scores...
August 2017: Neurobiology of Pain
https://www.readbyqxmd.com/read/29449242/novel-case-of-maternal-and-neonatal-kratom-dependence-and-withdrawal
#13
Lindsay Mackay, Ronald Abrahams
No abstract text is available yet for this article.
February 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29449080/influence-of-exercise-modality-on-cardiac-parasympathetic-and-sympathetic-indices-during-post-exercise-recovery
#14
Scott Michael, Ollie Jay, Kenneth S Graham, Glen M Davis
OBJECTIVES: This study investigated indirect measures of post-exercise parasympathetic reactivation (using heart-rate-variability, HRV) and sympathetic withdrawal (using systolic-time-intervals, STI) following upper- and lower-body exercise. DESIGN: Randomized, counter-balanced, crossover. METHODS: 13 males (age 26.4±4.7years) performed maximal arm-cranking (MAX-ARM) and leg-cycling (MAX-LEG). Subsequently, participants undertook separate 8-min bouts of submaximal HR-matched exercise of each mode (ARM and LEG)...
February 12, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29448961/nuclear-receptor-agonist-driven-modification-of-inflammation-and-amyloid-pathology-enhances-and-sustains-cognitive-improvements-in-a-mouse-model-of-alzheimer-s-disease
#15
Brad T Casali, Erin G Reed-Geaghan, Gary E Landreth
BACKGROUND: Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder characterized by pathological hallmarks of beta-amyloid plaque deposits, tau pathology, inflammation, and cognitive decline. Treatment remains a clinical obstacle due to lack of effective therapeutics. Agonists targeting nuclear receptors, such as bexarotene, reversed cognitive deficits regardless of treatment duration and age in murine models of AD. While bexarotene demonstrated marked efficacy in decreasing plaque levels following short-term treatment, prolonged treatment did not modulate plaque burden...
February 15, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29448295/recombinant-fxiii-rfxiii-a2-prophylaxis-prevents-bleeding-and-allows-for-surgery-in-patients-with-congenital-fxiii-a-subunit-deficiency
#16
Manuel Carcao, Carmen Altisent, Giancarlo Castaman, Katsuyuki Fukutake, Bryce A Kerlin, Craig Kessler, Riitta Lassila, Diane Nugent, Johannes Oldenburg, May-Lill Garly, Anders Rosholm, Aida Inbal
Recombinant factor XIII-A 2 (rFXIII-A 2 ) was developed for prophylaxis and treatment of bleeds in patients with congenital FXIII A-subunit deficiency. mentor™2 (NCT00978380), a multinational, open-label, single-arm, multiple-dosing extension to the pivotal mentor™1 trial, assessed long-term safety and efficacy of rFXIII-A 2 prophylaxis in eligible patients (patients with severe [<0.05 IU/mL] congenital FXIII subunit A deficiency) aged ≥6 years. Patients received 35 IU/kg rFXIII-A 2 (exact dosing) every 28 ± 2 days for ≥52 weeks...
February 15, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29447951/suction-electrode-recording-in-locus-coeruleus-of-newborn-rat-brain-slices-reveals-network-bursting-comprising-summated-non-synchronous-spiking
#17
Vladimir Rancic, Bijal Rawal, Bogdan Panaitescu, Araya Ruangkittisakul, Klaus Ballanyi
The brainstem locus coeruleus (LC) controling behaviors like arousal, sleep, breathing, pain or opioid withdrawal is an established model for spontaneous action potential synchronization. Such synchronous 'spiking' might produce an extracellular field potential (FP) which is a crucial tool for neural network analyses. We found using ≥10 μm tip diameter suction electrodes in newborn rat brainstem slices that the LC generates at ∼1 Hz a robust rhythmic FP (rFP). During distinct rFP phases, LC neurons discharge with a jitter of ±33 ms single spikes that summate to a ∼200 ms-lasting population burst...
February 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29447752/retracted-the-revised-stratigraphy-of-the-hominin-bearing-site-of-kromdraai-gauteng-south-africa-and-associated-perspectives
#18
Laurent Bruxelles, Richard Maire, Amélie Beaudet, Raymond Couzens, Francis Duranthon, Jean-Baptiste Fourvel, Dominic Stratford, Francis Thackeray, José Braga
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the co-Editors-in-Chief and the authors. The Results and Discussion of this article duplicate significant parts of book chapter "A revised stratigraphy of Kromdraai", published by L.B., R.M., R.C., F.T. and J.B. in Braga, J. and Thackeray, J.F. (Eds.), "Kromdraai. A Birthplace of Paranthropus in the Cradle of Humankind" (2016, SUN MeDIA MeTRO, pp...
January 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29447634/pityriasis-lichenoides-like-drug-reaction-a-clinical-histopathologic-study-of-10-cases
#19
Cynthia Magro, Ruifeng Guo, Giang Huong Nguyen, Hamilton Tsang, Shabnam Momtahen
BACKGROUND: Lymphomatoid drug reactions can mimic endogenous T and B cell lymphoproliferative diseases. OBJECTIVES: We present a novel form of cutaneous drug reaction with features of pityriasis lichenoides (PL), a recognized form of T cell dyscrasia. METHODS: Ten cases were studied where a cutaneous eruption exhibiting semblance to PL within a few weeks to months after starting a particular drug. RESULTS: The patient cohort comprised 7 females and 3 males with the mean age of 60 years...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447416/managing-opioid-use-disorder-and-co-occurring-posttraumatic-stress-disorder-among-veterans
#20
Rhonda Snow, Stephanie T Wynn
Support and safety measures are essential for Veterans admitted to acute psychiatric units with co-occurring posttraumatic stress disorder (PTSD) and opioid use disorder (OUD) to avoid unpleasant withdrawal symptoms. A human patient simulator was used to train clinicians to recognize opioid withdrawal symptoms. Clinicians were educated to assess for opioid withdrawal symptoms using the Clinical Opiate Withdrawal Scale. Knowledge was evaluated via pre/posttest. All participants' (N = 12) posttest scores improved...
February 15, 2018: Journal of Psychosocial Nursing and Mental Health Services
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