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Vivian C Nanagas, Anna Kovalszki
Hypereosinophilic syndrome and mastocytosis are relatively rare proliferative diseases encountered in the general population. However, allergists frequently consider these disorders in the differential of patients presenting with gastrointestinal, pulmonary, cutaneous, and allergic symptoms. Gastrointestinal symptoms are some of the most frequent and/or debilitating aspects of both disease states and in many cases lead to poor quality of life and functional limitation for the patient. They are the third most common clinical manifestation in hypereosinophilic syndrome and have been found to be the most distressful aspect of the disorder in those with systemic mastocytosis...
July 12, 2018: Clinical Reviews in Allergy & Immunology
Magdalena Kopczyńska, Łukasz Mokros, Tadeusz Pietras, Ewa Małecka-Panas
Introduction: While irritable bowel syndrome (IBS) is not life-threatening for most, it has enormous influence on quality of life (QOL) and mental health. Aim: To evaluate the association between QOL and depressive symptoms in IBS patients. Material and methods: A total of 87 patients and 56 healthy subjects were enrolled consecutively. All participants were asked to complete self-administered questionnaires: an IBS-specific quality of life (IBS-QOL) questionnaire and the Beck Depression Inventory questionnaire (BDI)...
2018: Przegla̜d Gastroenterologiczny
Li Jiang, Wenjun Xiao, Xuan Zhou, Weiyu Wang, Jun Fan
In this study, we analyzed and compared the properties of yeast Ulp1 protease in active inclusion bodies (IBs) as special protein immobilizate, and the soluble Ulp1 via oriented immobilization. Fusion of the N-terminal self-assembling peptide GFIL8 to the Ulp1 increased production of active IBs in Escherichia coli. Attachment of the N-terminal cellulose-binding module facilitated the constructed protein immobilized on the regenerated amorphous cellulose (RAC) with a binding capacity up to about 235 mg protein per gram of RAC...
July 10, 2018: Journal of Bioscience and Bioengineering
Muhammed Majeed, Kalyanam Nagabhushanam, Sivakumar Arumugam, Shaheen Majeed, Furqan Ali
Background: The modification of microbial ecology in human gut by supplementing probiotics may be an alternative strategy to ameliorate or prevent depression. Objective: The current study was conducted to assess the safety and efficacy of the probiotic strain Bacillus coagulans MTCC 5856 for major depressive disorder (MDD) in IBS patients. Method: Patients ( n = 40) diagnosed for MDD with IBS were randomized (1:1) to receive placebo or B. coagulans MTCC 5856 at a daily dose of 2 × 109 cfu (2 billion spores) and were maintained to the end of double-blind treatment (90 days)...
2018: Food & Nutrition Research
Qian Li, Bei-Ping Zhang, Shao-Gang Huang, Wen-Wei Ouyang, Jian-Hui Xie, Ze-Huai Wen, Xiao-Bo Yang
BACKGROUND: Irritable bowel syndrome (IBS) is a chronic, recurring condition, prevalent in the general population. Current medication treatments usually leave patients undertreated. Nowadays, Chinese medicine (CM) is being considered as a promising treatment approach for IBS. However, due to methodological limitations, there is no strong evidence to support CM. Although IBS relapses are common, the relapse assessment has always been neglected in CM study designs. Meanwhile, in clinical practice and studies, it has been found that certain CM formulas can only benefit certain kinds of patients...
July 11, 2018: Trials
Rosa Maria Chura-Chambi, Tatiana Rodrigues Fraga, Ludmila Bezerra da Silva, Bruno Bernardi Yamamoto, Lourdes Isaac, Angela Silva Barbosa, Ligia Morganti
Enzymes from the thermolysin family are crucial factors in the pathogenesis of several diseases caused by bacteria and are potential targets for therapeutic interventions. Thermolysin encoded by the gene LIC13322 of the causative agent of leptospirosis, Leptospira interrogans , was shown to cleave proteins from the Complement System. However, the production of this recombinant protein using traditional refolding processes with high levels of denaturing reagents for thermolysin inclusion bodies (TL-IBs) solubilization results in poor recovery and low proteolytic activity probably due to improper refolding of the protein...
September 2018: Biotechnology Reports
Michel Bouchoucha, Ghislain Devroede, Pierre Rompteaux, Bakhtiar Bejou, Jean-Marc Sabate, Robert Benamouzig
BACKGROUND/AIMS: Fecal soiling (FS) is the staining of underwear without loss of significant amounts of fecal material. It is frequently associated with defecation disorders in children. The aim of this study was to search for psychological and clinical correlates of adult patients with soiling. Clinically, the complaint of staining is confused with that of fecal incontinence (FI) in the mind of both patients and attending physicians. DESIGN: Observational study PATIENTS AND METHOD: We included 1454 consecutive outpatients (71% females)...
July 10, 2018: International Journal of Colorectal Disease
Arpa Hudait, Daniel R Moberg, Yuqing Qiu, Nathan Odendahl, Francesco Paesani, Valeria Molinero
Antifreeze proteins (AFPs) inhibit ice growth in organisms living in cold environments. Hyperactive insect AFPs are particularly effective, binding ice through "anchored clathrate" motifs. It has been hypothesized that the binding of hyperactive AFPs to ice is facilitated by preordering of water at the ice-binding site (IBS) of the protein in solution. The antifreeze protein Tm AFP displays the best matching of its binding site to ice, making it the optimal candidate to develop ice-like order in solution...
July 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
Sofie Ingdam Halkjær, Alice Højer Christensen, Bobby Zhao Sheng Lo, Patrick Denis Browne, Stig Günther, Lars Hestbjerg Hansen, Andreas Munk Petersen
OBJECTIVE: IBS is associated with an intestinal dysbiosis and faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients with IBS. We performed a randomised, double-blind placebo-controlled trial to investigate if FMT resulted in an altered gut microbiota and improvement in clinical outcome in patients with IBS. DESIGN: We performed this study in 52 adult patients with moderate-to-severe IBS. At the screening visit, clinical history and symptoms were assessed and faecal samples were collected...
July 6, 2018: Gut
Yukari Tanaka, Motoyori Kanazawa, Michiko Kano, Manabu Tashiro, Shin Fukudo
Corticotropin-releasing hormone (CRH) mediates stress responses in the brain-gut axis. Administration of CRH modulates brain activation, for example by controlling the autonomic nervous system in response to colorectal distention. Here, we investigated the relationship between sympathoadrenal and hypothalamic-pituitary-adrenal (HPA) responses to colorectal distention in patients with irritable bowel syndrome (IBS). We enrolled 32 patients with IBS (16 women and 16 men) and 32 healthy subjects (16 women and 16 men), and randomly divided them between CRH and saline injection groups...
2018: PloS One
Wei Zhao, Hong Jin, Mengque Xu, Dongxu Wang, Yandi Liu, Yanping Tang, Qiuzan Zhang, Jianping Hua, Bangmao Wang
Background: Functional gastrointestinal disorder (FGID) patients are influenced by anxiety, depression, and low sleep quality, which reduce the quality of their life. However, epidemiological data on the quality of sleep in FGID patients were lacking. This study aims to explore the sleep quality and influencing factors of the sleep quality in FGID patients. Methods: 1200 subjects, diagnosed as FGID in one of the six class-three hospitals in Tianjin, China, from January to December 2014, were recruited...
2018: BioMed Research International
John S Kane, Andrew J Irvine, Yannick Derwa, Olorunda Rotimi, Alexander C Ford
Background: Patients with microscopic colitis (MC) often present with abdominal pain and diarrhoea, and previous data suggest that there may be overlap between MC and irritable bowel syndrome (IBS). We evaluated the prevalence of IBS-type symptoms in patients with MC, and assess the impact of these symptoms on psychological health and quality of life. Methods: We conducted a cross-sectional survey of individuals with a histological diagnosis of MC, collecting demographic data, Rome III IBS-type symptoms, and mood, somatization, and quality of life data...
2018: Therapeutic Advances in Gastroenterology
Hao Wang, Yujiao Song
To achieve confidentiality, authentication, integrity of medical data, and support fine-grained access control, we propose a secure electronic health record (EHR) system based on attribute-based cryptosystem and blockchain technology. In our system, we use attribute-based encryption (ABE) and identity-based encryption (IBE) to encrypt medical data, and use identity-based signature (IBS) to implement digital signatures. To achieve different functions of ABE, IBE and IBS in one cryptosystem, we introduce a new cryptographic primitive, called combined attribute-based/identity-based encryption and signature (C-AB/IB-ES)...
July 5, 2018: Journal of Medical Systems
Monika Vij, Anthony Davies, Anu Dua, Robert Freeman
INTRODUCTION AND HYPOTHESIS: Patients in gynecology outpatient clinics (GOPDs) may present with symptoms that do not correlate well with the observed pathology and are usually labelled as having a functional disorder or medically unexplained symptoms (MUS). Underlying central sensitivity syndrome (CSS) with central sensitization (CS) as a potential mechanism may be responsible for some of their symptoms. The aim of this study is to identify the proportion of women with central sensitivity syndrome attending GOPDs...
July 4, 2018: International Urogynecology Journal
Kaige Li, Mengwei Guo, Lihua Tan, Xiaohong Li, Yanying Wu, Ying Lan, Wenlian Zhu, Yafang Zhao, Lufen Zhang, Xiaoxuan Ren
OBJECTIVE: To compare the effects of electroacupuncture (EA) at "Dachangshu" (BL 25) or "Tianshu" (ST 25) for visceral sensitivity, gene expression product c-kit of colonic Cajal interstitial cells (ICC) and capsaicin receptor 1 (TRPV1) of irritable bowel syndrome (IBS) rats, so as to investigate the effect and mechanism differences of EA at the back shu point and the front mu point of large intestine for IBS rats. METHODS: Forty-two Wistar neonatal rats were randomly divided into a blank group (9 rats) and a model group (33 rats)...
June 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Cristina Stasi, Anna Caserta, Cristiana Nisita, Sonia Cortopassi, Bernardo Fani, Stefano Salvadori, Pancetti Andrea, Lorenzo Bertani, Dario Gambaccini, Nicola de Bortoli, Liliana Dell'Osso, Corrado Blandizzi, Santino Marchi, Massimo Bellini
AIMS: To better define the relationship between IBS and psychiatric disorders and to examine the efficacy of paroxetine in the treatment of IBS patients. METHODS: 150 subjects with diagnosis of IBS (Roma III criteria) and relative sub-classification (constipated, diarrhea and mixed) were assessed for psychopathological features and gastrointestinal symptoms using IBS Symptom Severity Score and were consecutively enrolled. Fifty patients assumed paroxetine for 16 weeks and were longitudinally evaluated...
July 3, 2018: Journal of Gastroenterology and Hepatology
Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin
The pathogenesis of ME/CFS, a disease characterized by fatigue, cognitive dysfunction, sleep disturbances, orthostatic intolerance, fever, irritable bowel syndrome (IBS), and lymphadenopathy, is poorly understood. We report biomarker discovery and topological analysis of plasma metabolomic, fecal bacterial metagenomic, and clinical data from 50 ME/CFS patients and 50 healthy controls. We confirm reports of altered plasma levels of choline, carnitine and complex lipid metabolites and demonstrate that patients with ME/CFS and IBS have increased plasma levels of ceramide...
July 3, 2018: Scientific Reports
Tingting Su, Rongbei Liu, Allen Lee, Yanqin Long, Lijun Du, Sanchuan Lai, Xueqin Chen, Lan Wang, Jianmin Si, Chung Owyang, Shujie Chen
Alterations in gut microbiota are postulated to be an etiologic factor in the pathogenesis of irritable bowel syndrome (IBS). To determine whether IBS patients in China exhibited differences in their gut microbial composition, fecal samples were collected from diarrhea-predominant IBS (IBS-D) and healthy controls and evaluated by 16S ribosomal RNA gene sequence and quantitative real-time PCR. A mouse model of postinfectious IBS (PI-IBS) was established to determine whether the altered gut microbiota was associated with increased visceral hypersensitivity...
2018: Gastroenterology Research and Practice
Tsukasa Nozu, Saori Miyagishi, Shima Kumei, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura
BACKGROUND AND AIM: Metformin has been shown to have anti-cytokine property. Lipopolysaccharide (LPS)- or repeated water avoidance stress (WAS)-induced visceral allodynia and increased gut permeability were proinflammatory cytokine-dependent responses, which were considered to be animal models of irritable bowel syndrome (IBS). We hypothesized that metformin improves symptoms in the patients with IBS by attenuating these visceral changes and tested the hypothesis in rats. METHODS: The threshold of the visceromotor response (VMR) induced by colonic balloon distention was measured...
July 2, 2018: Journal of Gastroenterology and Hepatology
Santosh Kumar Palanirajan, Sathyanarayana N Gummadi
Human phospholipid scramblase 1 (hPLSCR1) is an ATP independent, Ca2+ dependent transmembrane protein mediating bidirectional translocation of phospholipids across the lipid bilayer but the mechanism of scrambling is unknown. Determination of the hPLSCR1 structure would help understand the mechanism and its multi-functional property. Recombinant hPLSCR1 forms inclusion bodies (IBs), when over-expressed in E. coli BL21 (DE3) and recovery of active hPLSCR1 from IBs, were time-consuming and resulted in low protein yield...
June 29, 2018: Analytical Biochemistry
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