keyword
https://read.qxmd.com/read/38447663/diagnosis-of-indeterminate-biliary-strictures-gie-top-tips-for-advanced-endoscopy
#1
JOURNAL ARTICLE
James Buxbaum
No abstract text is available yet for this article.
March 4, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38420150/the-bethesda-ercp-skills-assessment-tool-besat-can-reliably-differentiate-endoscopists-of-different-experience-levels
#2
JOURNAL ARTICLE
Kevin Liu, B Joseph Elmunzer, Sachin Wani, Tiffany Taft, Catharine M Walsh, Mustafa A Arain, Tyler M Berzin, James Buxbaum, Christopher DiMaio, Syed M Abbas Fehmi, Neil Gupta, Sreenivasa Jonnalagadda, Vladimir Kushnir, John T Maple, Raman Muthusamy, Amit Rastogi, Janak N Shah, Amitabh Chak, Ashley Faulx, Nauzer Forbes, Rajesh N Keswani
Background and study aims The Bethesda ERCP Skill Assessment Tool (BESAT) is a video-based assessment tool of technical endoscopic retrograde cholangiopancreatography (ERCP) skill with previously established validity evidence. We aimed to assess the discriminative validity of the BESAT in differentiating ERCP skill levels. Methods Twelve experienced ERCP practitioners from tertiary academic centers were asked to blindly rate 43 ERCP videos using the BESAT. ERCP videos consisted of native biliary cannulation and sphincterotomy and were recorded from 10 unique endoscopists of various ERCP experience (from advanced endoscopy fellow to > 10 years of ERCP experience)...
February 2024: Endoscopy International Open
https://read.qxmd.com/read/38219767/indomethacin-with-or-without-prophylactic-pancreatic-stent-placement-to-prevent-pancreatitis-after-ercp-a-randomised-non-inferiority-trial
#3
JOURNAL ARTICLE
B Joseph Elmunzer, Lydia D Foster, Jose Serrano, Gregory A Coté, Steven A Edmundowicz, Sachin Wani, Raj Shah, Ji Young Bang, Shyam Varadarajulu, Vikesh K Singh, Mouen Khashab, Richard S Kwon, James M Scheiman, Field F Willingham, Steven A Keilin, Georgios I Papachristou, Amitabh Chak, Adam Slivka, Daniel Mullady, Vladimir Kushnir, James Buxbaum, Rajesh Keswani, Timothy B Gardner, Nauzer Forbes, Amit Rastogi, Andrew Ross, Joanna Law, Patrick Yachimski, Yen-I Chen, Alan Barkun, Zachary L Smith, Bret Petersen, Andrew Y Wang, John R Saltzman, Rebecca L Spitzer, Collins Ordiah, Cathie Spino, Valerie Durkalski-Mauldin
BACKGROUND: The combination of rectally administered indomethacin and placement of a prophylactic pancreatic stent is recommended to prevent pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) in high-risk patients. Preliminary evidence suggests that the use of indomethacin might eliminate or substantially reduce the need for stent placement, a technically complex, costly, and potentially harmful intervention. METHODS: In this randomised, non-inferiority trial conducted at 20 referral centres in the USA and Canada, patients (aged ≥18 years) at high risk for post-ERCP pancreatitis were randomly assigned (1:1) to receive rectal indomethacin alone or the combination of indomethacin plus a prophylactic pancreatic stent...
January 11, 2024: Lancet
https://read.qxmd.com/read/38112649/a-preliminary-controlled-trial-of-endoscopic-ultrasound-guided-fiducial-markers-to-guide-pancreas-surgery
#4
JOURNAL ARTICLE
Patrick W Chang, Jonathan Sadik, Ara B Sahakian, Ravi Kankotia, Christopher Ko, Jessica Serna, Alex Rodriguez, Helen Lee, Sujit Kulkarni, Yuri Genyk, Mohd Sheikh, James L Buxbaum
OBJECTIVE: Endoscopic ultrasound (EUS) is routinely used for fiducial marker placement (FMP) to guide stereotactic radiation of pancreatic tumors, but EUS-FMP explicitly to guide surgery has not been studied in a prospective, controlled manner. Multipurpose EUS systems have been developed that facilitate simultaneous EUS-FMP at the time of biopsy. We aimed to evaluate the feasibility of EUS-FMP to guide pancreatic resection. METHODS: In this prospective trial, we enrolled patients with resectable pancreas masses undergoing tissue sampling and placed preloaded fiducials immediately after biopsy...
December 19, 2023: Journal of Clinical Gastroenterology
https://read.qxmd.com/read/38103842/a-randomized-controlled-phase-2-dose-finding-trial-to-evaluate-the-efficacy-and-safety-of-camostat-in-the-treatment-of-painful-chronic-pancreatitis-the-tactic-study
#5
JOURNAL ARTICLE
Phil A Hart, Yurii Osypchuk, Iryna Hovbakh, Raj J Shah, Jose Nieto, Gregory A Cote, Sergii Avgaitis, Oleksandr Kremzer, James Buxbaum, Sumant Inamdar, Ronnie Fass, Raymond W Phillips, Dhiraj Yadav, Antonio Mendoza Ladd, M Tarek Al-Assi, Timothy Gardner, Darwin L Conwell, Shayan Irani, Aasim Sheikh, Janet Nuttall
BACKGROUND AND AIMS: Chronic pancreatitis (CP) causes an abdominal pain syndrome associated with poor quality of life (QOL). We conducted a clinical trial to further investigate the efficacy and safety of camostat, an oral serine protease inhibitor, which has been used to alleviate pain in CP. METHODS: This was a double-blind randomized controlled trial that enrolled adults with CP with a baseline average daily worst pain score ≥4 using the numeric rating system (NRS)...
December 14, 2023: Gastroenterology
https://read.qxmd.com/read/38079517/population-based-evaluation-of-disparities-in-stomach-cancer-by-nativity-among-asian-and-hispanic-populations-in-california-2011-2015
#6
JOURNAL ARTICLE
Eunjung Lee, Kai-Ya Tsai, Juanjuan Zhang, Amie E Hwang, Dennis Deapen, Jennifer J Koh, Eric S Kawaguchi, James Buxbaum, Sang Hoon Ahn, Lihua Liu
BACKGROUND: Stomach cancer incidence presents significant racial/ethnic disparities among racial/ethnic minority groups in the United States, particularly among Asian and Hispanic immigrant populations. However, population-based evaluation of disparities by nativity has been scarce because of the lack of nativity-specific population denominators, especially for disaggregated Asian subgroups. Population-based stomach cancer incidence and tumor characteristics by detailed race/ethnicity and nativity were examined...
December 11, 2023: Cancer
https://read.qxmd.com/read/38016473/an-evolutionary-perspective-on-complex-neuropsychiatric-disease
#7
REVIEW
J M McClellan, Anthony W Zoghbi, Joseph D Buxbaum, Carolina Cappi, James J Crowley, Jonathan Flint, Dorothy E Grice, Suleyman Gulsuner, Conrad Iyegbe, Sanjeev Jain, Po-Hsiu Kuo, Maria Claudia Lattig, Maria Rita Passos-Bueno, Meera Purushottam, Dan J Stein, Anna B Sunshine, Ezra S Susser, Christopher A Walsh, Olivia Wootton, Mary-Claire King
The forces of evolution-mutation, selection, migration, and genetic drift-shape the genetic architecture of human traits, including the genetic architecture of complex neuropsychiatric illnesses. Studying these illnesses in populations that are diverse in genetic ancestry, historical demography, and cultural history can reveal how evolutionary forces have guided adaptation over time and place. A fundamental truth of shared human biology is that an allele responsible for a disease in anyone, anywhere, reveals a gene critical to the normal biology underlying that condition in everyone, everywhere...
November 27, 2023: Neuron
https://read.qxmd.com/read/37980922/upfront-endoscopic-necrosectomy-or-step-up-endoscopic-approach-for-infected-necrotising-pancreatitis-destin-a-single-blinded-multicentre-randomised-trial
#8
RANDOMIZED CONTROLLED TRIAL
Ji Young Bang, Sundeep Lakhtakia, Shyam Thakkar, James L Buxbaum, Irving Waxman, Bryce Sutton, Sana F Memon, Shailendra Singh, Jahangeer Basha, Ajay Singh, Udayakumar Navaneethan, Robert H Hawes, Charles M Wilcox, Shyam Varadarajulu
BACKGROUND: Although the preferred management approach for patients with infected necrotising pancreatitis is endoscopic transluminal stenting followed by endoscopic necrosectomy as step-up treatment if there is no clinical improvement, the optimal timing of necrosectomy is unclear. Therefore, we aimed to compare outcomes between performing upfront necrosectomy at the index intervention versus as a step-up measure in patients with infected necrotising pancreatitis. METHODS: This single-blinded, multicentre, randomised trial (DESTIN) was done at six tertiary care hospitals (five hospitals in the USA and one hospital in India)...
January 2024: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/37946624/latin-american-trans-ancestry-initiative-for-ocd-genomics-latino-study-protocol
#9
JOURNAL ARTICLE
James J Crowley, Carolina Cappi, Marcos E Ochoa-Panaifo, Renee M Frederick, Minjee Kook, Andrew D Wiese, Diana Rancourt, Elizabeth G Atkinson, Paola Giusti-Rodriguez, Jacey L Anderberg, Jonathan S Abramowitz, Victor R Adorno, Cinthia Aguirre, Gilberto S Alves, Gustavo S Alves, NaEshia Ancalade, Alejandro A Arellano Espinosa, Paul D Arnold, Daphne M Ayton, Izabela G Barbosa, Laura Marcela Barón Castano, Cynthia N Barrera, María Celeste Berardo, Dayan Berrones, John R Best, Tim B Bigdeli, Christie L Burton, Joseph D Buxbaum, Jennifer L Callahan, Maria Cecília B Carneiro, Sandra L Cepeda, Evelyn Chazelle, Jessica M Chire, Macarena Churruca Munoz, Pamela Claisse Quiroz, Journa Cobite, Jonathan S Comer, Daniel L Costa, Jennifer Crosbie, Victor O Cruz, Guillermo Dager, Luisa F Daza, Anabel de la Rosa-Gómez, Daniela Del Río, Fernanda Z Delage, Carolina B Dreher, Lucila Fay, Tomas Fazio, Ygor A Ferrão, Gabriela M Ferreira, Edith G Figueroa, Leonardo F Fontenelle, Diego A Forero, Daniele T H Fragoso, Bharathi S Gadad, Sheldon R Garrison, Andres González, Laura D Gonzalez, Marco A González, Polaris Gonzalez-Barrios, Wayne K Goodman, Dorothy E Grice, Jerry Guintivano, Daniel G Guttfreund, Andrew G Guzick, Matthew W Halvorsen, Joseph D Hovey, Hailiang Huang, Jonathan Irreño-Sotomonte, Reinhard Janssen-Aguilar, Matias Jensen, Alexandra Z Jimenez Reynolds, Joali Alexandra Juárez Lujambio, Nasim Khalfe, Madison A Knutsen, Caleb Lack, Nuria Lanzagorta, Monicke O Lima, Melanie O Longhurst, David A Lozada Martinez, Elba S Luna, Andrea H Marques, Molly S Martinez, Maria de Los Angeles Matos, Caitlyn E Maye, Joseph F McGuire, Gabriela Menezes, Charlene Minaya, Tomás Miño, Sara M Mithani, Circe Montes de Oca, Alonso Morales-Rivero, Maria E Moreira-de-Oliveira, Olivia J Morris, Sandra I Muñoz, Zainab Naqqash, Ambar A Núñez Bracho, Belinda E Núñez Bracho, Maria Corina Ochoa Rojas, Luis A Olavarria Castaman, Trinidad Olivos Balmaceda, Iliana Ortega, Darpan I Patel, Ainsley K Patrick, Mariel Paz Y Mino, Jose L Perales Orellana, Bárbara Perdigão Stumpf, Tamara Peregrina, Tania Pérez Duarte, Kelly L Piacsek, Maritza Placencia, María Belén Prieto, Lucas C Quarantini, Yana Quarantini-Alvim, Renato T Ramos, Iaroslava C Ramos, Vanessa R Ramos, Kesley A Ramsey, Elise V Ray, Margaret A Richter, Bradley C Riemann, Juan C Rivas, Maria C Rosario, Camilo J Ruggero, Angel A Ruiz-Chow, Alejandra Ruiz-Velasco, Melisa N Sagarnaga, Aline S Sampaio, Leonardo C Saraiva, Russell J Schachar, Sophie C Schneider, Ethan J Schweissing, Laura D Seligman, Roseli G Shavitt, Keaton J Soileau, S Evelyn Stewart, Shaina B Storch, Emily R Strouphauer, Vissente Tapia Cuevas, Kiara R Timpano, Beatriz Treviño-de la Garza, Alexie Vallejo-Silva, Javier Vargas-Medrano, María I Vásquez, Guadalupe Vidal Martinez, Saira A Weinzimmer, Mauricio A Yanez, Gwyneth Zai, Lina M Zapata-Restrepo, Luz M Zappa, Raquel M Zepeda-Burgos, Anthony W Zoghbi, Euripedes C Miguel, Carolyn I Rodriguez, Mayra C Martinez Mallen, Pablo R Moya, Tania Borda, María Beatriz Moyano, Manuel Mattheisen, Stacey Pereira, Gabriel Lázaro-Muñoz, Karen G Martinez-Gonzalez, Michele T Pato, Humberto Nicolini, Eric A Storch
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics...
November 9, 2023: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://read.qxmd.com/read/37818454/underwater-versus-conventional-endoscopic-mucosal-resection-for-colorectal-lesions-an-updated-meta-analysis-of-randomized-controlled-trials
#10
REVIEW
Aneesa Rahman Chowdhury, Jin Sun Kim, Mimi Xu, Chloe Tom, Rachan Narala, Niwen Kong, Helen Lee, Alejandro Vazquez, Ara Sahakian, Jennifer Phan, James Buxbaum
Background and study aims Colorectal malignancy is a leading cause of death. Conventional endoscopic mucosal resection (CEMR) is a strategy used to resect precancerous lesions that involves injecting fluid beneath a polyp to create a gap for resection. Underwater endoscopic mucosal resection (UEMR) is a newer method that forgoes injection, instead filling the intestinal cavity with water to facilitate polyp resection. Our aim was to compare the safety and efficacy of these approaches by synthesizing the most contemporary evidence...
October 2023: Endoscopy International Open
https://read.qxmd.com/read/37699524/a-machine-learning-based-choledocholithiasis-prediction-tool-to-improve-ercp-decision-making-a-proof-of-concept-study
#11
JOURNAL ARTICLE
Steven N Steinway, Bohao Tang, Jeremy Telezing, Aditya Ashok, Ayesha Kamal, Chung Yao Yu, Nitin Jagtap, James L Buxbaum, Joseph Elmunzer, Sachin B Wani, Mouen A Khashab, Brian S Caffo, Venkata S Akshintala
BACKGROUND: Previous studies demonstrated limited accuracy of existing guidelines for predicting choledocholithiasis, leading to overutilization of endoscopic retrograde cholangiopancreatography (ERCP). More accurate stratification may improve patient selection for ERCP and allow use of lower-risk modalities. METHODS: A machine learning model was developed using patient information from two published cohort studies that evaluated performance of guidelines in predicting choledocholithiasis...
November 29, 2023: Endoscopy
https://read.qxmd.com/read/37673135/are-the-elements-fulfilled-for-adoption-of-eus-guided-choledochoduodenostomy-as-a-first-line-modality
#12
EDITORIAL
James L Buxbaum, Iris Lansdorp Vogelaar
No abstract text is available yet for this article.
September 4, 2023: Gastroenterology
https://read.qxmd.com/read/37567847/female-patients-delay-seeking-medical-care-with-alcohol-associated-acute-pancreatitis
#13
JOURNAL ARTICLE
Christie Y Jeon, Esther Adeniran, Connor Stewart, Georgios I Papachristou, Joseph R Pisegna, Alma A Kuc, James L Buxbaum, Stephen J Pandol, Dhiraj Yadav
BACKGROUND/OBJECTIVE: Alcohol consumption is increasing in women, who more frequently report abdominal symptoms compared to men. We aimed to examine differences in presentation of acute pancreatitis [AP] in male and female patients hospitalized with alcohol-associated AP. METHODS: We analyzed 138 patients enrolled in an ongoing case-crossover study of alcohol-associated AP conducted across 5 medical centers in the U.S. Patients meeting the Revised Atlanta Classification of AP and who scored 3 or higher on the AUDIT-C instrument were invited to participate in the study and were interviewed while hospitalized with AP...
August 5, 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37498266/american-society-for-gastrointestinal-endoscopy-guideline-on-endoscopic-submucosal-dissection-for-the-management-of-early-esophageal-and-gastric-cancers-summary-and-recommendations
#14
JOURNAL ARTICLE
Nauzer Forbes, Sherif E Elhanafi, Mohammad A Al-Haddad, Nirav C Thosani, Peter V Draganov, Mohamed O Othman, Eugene P Ceppa, Vivek Kaul, Michael M Feely, Ilyas Sahin, James L Buxbaum, Audrey H Calderwood, Jean M Chalhoub, Nayantara Coelho-Prabhu, Madhav Desai, Larissa L Fujii-Lau, Divyanshoo R Kohli, Richard S Kwon, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly Ruan, Sunil G Sheth, Andrew C Storm, Nikhil R Thiruvengadam, Bashar J Qumseya
This clinical practice guideline from the American Society for Gastrointestinal Endoscopy (ASGE) provides an evidence-based summary and recommendations regarding the role of endoscopic submucosal dissection (ESD) in the management of early esophageal and gastric cancers. It is accompanied by the document subtitled "Methodology and Review of Evidence," which provides a detailed account of the methodology used for the evidence review. This guideline was developed using the Grading of Recommendations, Assessment, Development and Evaluation framework and specifically addresses the role of ESD versus EMR and/or surgery, where applicable, for the management of early esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), and gastric adenocarcinoma (GAC) and their corresponding precursor lesions...
September 2023: Gastrointestinal Endoscopy
https://read.qxmd.com/read/37498265/american-society-for-gastrointestinal-endoscopy-guideline-on-endoscopic-submucosal-dissection-for-the-management-of-early-esophageal-and-gastric-cancers-methodology-and-review-of-evidence
#15
Mohammad A Al-Haddad, Sherif E Elhanafi, Nauzer Forbes, Nirav C Thosani, Peter V Draganov, Mohamed O Othman, Eugene P Ceppa, Vivek Kaul, Michael M Feely, Ilyas Sahin, Yibing Ruan, Behnam Sadeghirad, Rebecca L Morgan, James L Buxbaum, Audrey H Calderwood, Jean M Chalhoub, Nayantara Coelho-Prabhu, Madhav Desai, Larissa L Fujii-Lau, Divyanshoo R Kohli, Richard S Kwon, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly Ruan, Sunil G Sheth, Andrew C Storm, Nikhil R Thiruvengadam, Bashar J Qumseya
This document from the American Society for Gastrointestinal Endoscopy (ASGE) provides a full description of the methodology used in the review of the evidence used to inform the final guidance outlined in the accompanying Summary and Recommendations document regarding the role of endoscopic submucosal dissection (ESD) in the management of early esophageal and gastric cancers. This guideline used the Grading of Recommendations, Assessment, Development and Evaluation framework and specifically addresses the role of ESD versus EMR and/or surgery, where applicable, for the management of early esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), and gastric adenocarcinoma (GAC) and their corresponding precursor lesions...
July 25, 2023: Gastrointestinal Endoscopy
https://read.qxmd.com/read/37461624/multi-ancestry-genome-wide-meta-analysis-of-56-241-individuals-identifies-lrrc4c-lhx5-as1-and-nominates-ancestry-specific-loci-ptprk-grb14-and-kiaa0825-as-novel-risk-loci-for-alzheimer-s-disease-the-alzheimer-s-disease-genetics-consortium
#16
Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan-Ping Lee, Jacob Haut, Kara L Hamilton-Nelson, Nicholas R Wheeler, Yi Zhao, John J Farrell, Michelle A Grunin, Yuk Yee Leung, Pavel P Kuksa, Donghe Li, Eder Lucio da Fonseca, Jesse B Mez, Ellen L Palmer, Jagan Pillai, Richard M Sherva, Yeunjoo E Song, Xiaoling Zhang, Taha Iqbal, Omkar Pathak, Otto Valladares, Amanda B Kuzma, Erin Abner, Perrie M Adams, Alyssa Aguirre, Marilyn S Albert, Roger L Albin, Mariet Allen, Lisa Alvarez, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Gayle Ayres, Clinton T Baldwin, Robert C Barber, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Gary W Beecham, Duane Beekly, Bruno A Benitez, David Bennett, John Bertelson, Thomas D Bird, Deborah Blacker, Bradley F Boeve, James D Bowen, Adam Boxer, James Brewer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Laura B Cantwell, Chuanhai Cao, Christopher S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Scott Chasse, Marie-Francoise Chesselet, Nathaniel A Chin, Helena C Chui, Jaeyoon Chung, Suzanne Craft, Paul K Crane, David H Cribbs, Elizabeth A Crocco, Carlos Cruchaga, Michael L Cuccaro, Munro Cullum, Eveleen Darby, Barbara Davis, Philip L De Jager, Charles DeCarli, John DeToledo, Malcolm Dick, Dennis W Dickson, Beth A Dombroski, Rachelle S Doody, Ranjan Duara, NIlüfer Ertekin-Taner, Denis A Evans, Kelley M Faber, Thomas J Fairchild, Kenneth B Fallon, David W Fardo, Martin R Farlow, Victoria Fernandez-Hernandez, Steven Ferris, Tatiana M Foroud, Matthew P Frosch, Brian Fulton-Howard, Douglas R Galasko, Adriana Gamboa, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Alison M Goate, Thomas J Grabowski, Neill R Graff-Radford, Robert C Green, John H Growdon, Hakon Hakonarson, James Hall, Ronald L Hamilton, Oscar Harari, John Hardy, Lindy E Harrell, Elizabeth Head, Victor W Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S Honig, Ryan M Huebinger, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Linda S Hynan, Laura Ibanez, Gail P Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M Ilyas Kamboh, Anna M Karydas, Mindy J Katz, John S Kauwe, Jeffrey A Kaye, C Dirk Keene, Aisha Khaleeq, Ronald Kim, Janice Knebl, Neil W Kowall, Joel H Kramer, Walter A Kukull, Frank M LaFerla, James J Lah, Eric B Larson, Alan Lerner, James B Leverenz, Allan I Levey, Andrew P Lieberman, Richard B Lipton, Mark Logue, Oscar L Lopez, Kathryn L Lunetta, Constantine G Lyketsos, Douglas Mains, Flanagan E Margaret, Daniel C Marson, Eden R R Martin, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Stefan McDonough, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Thomas J Montine, Edwin S Monuki, John C Morris, Shubhabrata Mukherjee, Amanda J Myers, Trung Nguyen, Sid O'Bryant, John M Olichney, Marcia Ory, Raymond Palmer, Joseph E Parisi, Henry L Paulson, Valory Pavlik, David Paydarfar, Victoria Perez, Elaine Peskind, Ronald C Petersen, Aimee Pierce, Marsha Polk, Wayne W Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F Quinn, Ashok Raj, Murray Raskind, Eric M Reiman, Barry Reisberg, Joan S Reisch, John M Ringman, Erik D Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Donald R Royall, Mark A Sager, Mary Sano, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Susan H Slifer, Scott Small, Amanda G Smith, Janet P Smith, Joshua A Sonnen, Salvatore Spina, Peter St George-Hyslop, Robert A Stern, Alan B Stevens, Stephen M Strittmatter, David Sultzer, Russell H Swerdlow, Rudolph E Tanzi, Jeffrey L Tilson, John Q Trojanowski, Juan C Troncoso, Debby W Tsuang, Vivianna M Van Deerlin, Linda J van Eldik, Jeffery M Vance, Badri N Vardarajan, Robert Vassar, Harry V Vinters, Jean-Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Patrice L Whitehead, Ellen M Wijsman, Kirk C Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S Wingo, Thomas Wisniewski, Randall L Woltjer, Martin Woon, Clinton B Wright, Chuang-Kuo Wu, Steven G Younkin, Chang-En Yu, Lei Yu, Xiongwei Zhu, Brian W Kunkle, William S Bush, Li-San Wang, Lindsay A Farrer, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard D Schellenberg, Gyungah R Jun, Christiane Reitz, Adam C Naj
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer's Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within-ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis...
July 8, 2023: medRxiv
https://read.qxmd.com/read/37428139/lactated-ringers-use-in-the-first-24-hours-of-hospitalization-is-associated-with-improved-outcomes-in-999-patients-with-acute-pancreatitis
#17
MULTICENTER STUDY
Peter J Lee, Stacey Culp, Ayesha Kamal, Pedram Paragomi, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh Kumar Goenka, Aiste Gulla, Jose Gonzales, Tyler Stevens, Sorin Barbu, Haq Nawaz, Silvia Gutierrez, Narcis Zarnescu, Gabriele Capurso, Jeff Easler, Konstantinos Triantafyllou, Carlos Ocampo, Enrique de-Madaria, Bechien Wu, Phil A Hart, Venkata S Akshintala, Vikesh K Singh, Jason Bischof, James Buxbaum, Mario Pelaez, Georgios I Papachristou
INTRODUCTION: Recent pilot trials in acute pancreatitis (AP) found that lactated ringers (LR) usage may result in decreased risk of moderately severe/severe AP compared with normal saline, but their small sample sizes limit statistical power. We investigated whether LR usage is associated with improved outcomes in AP in an international multicenter prospective study. METHODS: Patients directly admitted with the diagnosis of AP were prospectively enrolled at 22 international sites between 2015 and 2018...
December 1, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/37344583/advances-in-the-management-of-acute-pancreatitis
#18
JOURNAL ARTICLE
Enrique de-Madaria, James L Buxbaum
No abstract text is available yet for this article.
November 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37339277/increasing-antibiotic-resistant-infections-with-inpatient-endoscopic-retrograde-cholangioscopies-ercp-is-associated-with-higher-mortality-in-the-united-states-a-cross-sectional-cohort-study
#19
JOURNAL ARTICLE
Patrick W Chang, Aileen Bui, Selena Zhou, Ara B Sahakian, James L Buxbaum, Jennifer Phan
GOALS: This study aims to investigate associated mortality with inpatient endoscopic retrograde cholangiopancreatography (ERCP) with and without resistant infections. The co-primary objective compares frequencies of inpatient ERCP with resistant infections to overall hospitalizations with resistant infections. BACKGROUND: The risks of inpatient antibiotic-resistant organisms are known, but the associated mortality for inpatient ERCP is unknown. We aim to use a national database of hospitalizations and procedures to understand trends and mortality for patients with antibiotic-resistant infections during inpatient ERCP...
June 19, 2023: Journal of Clinical Gastroenterology
https://read.qxmd.com/read/37307901/american-society-for-gastrointestinal-endoscopy-guideline-on-role-of-endoscopy-in-the-diagnosis-of-malignancy-in-biliary-strictures-of-undetermined-etiology-methodology-and-review-of-evidence
#20
Larissa L Fujii-Lau, Nirav C Thosani, Mohammad Al-Haddad, Jared Acoba, Curtis J Wray, Rodrick Zvavanjanja, Stuart K Amateau, James L Buxbaum, Sachin Wani, Audrey H Calderwood, Jean M Chalhoub, Nayantara Coelho-Prabhu, Madhav Desai, Sherif E Elhanafi, Douglas S Fishman, Nauzer Forbes, Laith H Jamil, Terry L Jue, Divyanshoo R Kohli, Richard S Kwon, Joanna K Law, Jeffrey K Lee, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly Ruan, Mandeep S Sawhney, Sunil G Sheth, Andrew Storm, Nikhil R Thiruvengadam, Bashar J Qumseya
Biliary strictures of undetermined etiology pose a diagnostic challenge for endoscopists. Despite advances in technology, diagnosing malignancy in biliary strictures often requires multiple procedures. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework was used to rigorously review and synthesize the available literature on strategies used to diagnose undetermined biliary strictures. Using a systematic review and meta-analysis of each diagnostic modality, including fluoroscopic-guided biopsy sampling, brush cytology, cholangioscopy, and EUS-guided FNA or fine-needle biopsy sampling, the American Society for Gastrointestinal Endoscopy Standards of Practice Committee provides this guideline on modalities used to diagnose biliary strictures of undetermined etiology...
November 2023: Gastrointestinal Endoscopy
keyword
keyword
104798
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.