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Reducing caesarian section rate

Q Jiang, W Y Liu, W Feng, H H Jia, F Hou
Objective: To investigate the effect of prenatal administration of tetrandrine on the expression of Kruppel-like factors 5 (KLF5) and Survivin in the lung of congenital diaphragmatic hernia (CDH) rat model. Methods: This experiment took simple random group method, 11 pregnant SD rats were randomly divided into three groups: normal control group (group NC, 3), model control group (group MC, 4), model+ tetrandrine group (group MT, 4). The rats in group MC and MT were given gavage administration with 125 mg nitrofen to induce CDH and the rats in group MT were administered with 30 mg/kg tetrandrine for three days (gestational age of 18...
February 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
M N Islam, T Tazmin, M Siddika, M A Hossain, M A Ali, M K Bhuiyan
Multiple pregnancies are a significant risk factor for maternal and perinatal morbidity due to inherent biological risks. The present study was aimed to determine the risk factors and to evaluate the immediate neonatal outcome of multiple pregnancies. This descriptive observational study was conducted in the newly established Special Care Neonatal Unit (SCANU) of Mymensingh Medical College Hospital (MMCH), Bangladesh from January 2015 to March 2015. Total 86 newborns of multiple pregnancies who were admitted during the study period were included in the study...
January 2018: Mymensingh Medical Journal: MMJ
Martin Poryo, Judith Caroline Boeckh, Ludwig Gortner, Michael Zemlin, Perrine Duppré, Daniel Ebrahimi-Fakhari, Stefan Wagenpfeil, Matthias Heckmann, Eva Mildenberger, Anne Hilgendorff, Andreas W Flemmer, Georg Frey, Sascha Meyer
BACKGROUND: Intraventricular hemorrhage (IVH) is one of the most serious complications in preterm infants and is associated with neurological sequelae and mortality. Over the past few decades, the rate of IVH has decreased due to improved neonatal intensive care. However, up to 15-25% of very and extremely premature infants (<32 and <28weeks of pregnancy (WOP) respectively) still suffer from IVH. STUDY PURPOSE: The aim of this study was to perform an updated, multicenter analysis to identify ante-, peri, and postnatal factors other than gestational age/birth weight associated with IVH of any grade in a large cohort of very and extremely premature infants...
October 26, 2017: Early Human Development
Malik Goonewardene, M Peiris, S Kariyawasam, S Mallawaaratchi, D Kadawathage, L Sanjeewa, P Widanapathirana, I Sandeepani
Objective: To identify possible methods of reducing high caesarean section rates in a tertiary care hospital. Methods: Analysis of birth weight of neonates, maternal age and indications for caesarean section in the groups identified by a modification of Robson’s 10 Group Classification of caesarean section (TGCS), which contribute significantly to the high caesarean section rates in the University Obstetric Unit, Teaching Hospital Mahamodara, Galle Sri Lanka during 2010 - to 2014...
September 30, 2017: Ceylon Medical Journal
Joseph Mendlovic, Ethel-Sherry Gordon, Ziona Haklai, Jill Meron, Arnon Afek
BACKGROUND: Medical practice variation refers to differences in health service utilization among regions in the same country. It is used as a tool for studying health inequities. In 2011, the OECD launched a Medical Practice Variation Project which examines regional differences within countries and explores the sources of the inter-regional differences. The aim of this study is to examine the patterns and trends in geographic variation for selected health services in Israel. METHODS: The analysis is based on data from the National Hospital Discharges Database (NHDD) of the Israeli Ministry of Health...
2017: Israel Journal of Health Policy Research
Jennifer B Wasserman, Jessica L Steele-Thornborrow, Jeremy S Yuen, Melissa Halkiotis, Elizabeth M Riggins
OBJECTIVE: To describe outcomes of two subjects with chronically painful Caesarian section (C-section) scars following an intervention of specific myofascial scar release techniques. STUDY DESIGN: Case series. BACKGROUND: Over 1.3 million C-sections are performed annually in the US. Anywhere from 7 to 18% of those will develop chronic scar pain. Although anecdotal evidence supporting the use of fascial release in reducing surgical scar pain exists, almost no research has been published...
October 2016: Journal of Bodywork and Movement Therapies
Zhen-Yu Luo, Song Quan, Dong-Ning Chai, Wei-Hong Zhang
The retrospective cohort epidemiological study was to investigate the characteristics of women who underwent induced abortion. Data were retrospectively collected from women who underwent induced abortions (n = 19,655) at the Xiamen Maternity and Child Health Care Hospital (2010-2013). The characteristics of women who underwent induced abortions included mean age, unmarried status, no previous deliveries, first pregnancy, ≥2 abortions including the current one, and a history of caesarian section. From 2010 to 2013, mean age increased and declines were observed in the ratio of induced abortions to live births, the proportion of induced abortions among women of 15-24 years, those who were unmarried, had their first pregnancy, or had no history of delivery...
2016: BioMed Research International
J Robert Smith, Kyle Pfeifer, Florian Petry, Natalie Powell, Jennifer Delzeit, Mark L Weiss
Umbilical cord derived mesenchymal stromal cells (UC-MSCs) are a focus for clinical translation but standardized methods for isolation and expansion are lacking. Previously we published isolation and expansion methods for UC-MSCs which presented challenges when considering good manufacturing practices (GMP) for clinical translation. Here, a new and more standardized method for isolation and expansion of UC-MSCs is described. The new method eliminates dissection of blood vessels and uses a closed-vessel dissociation following enzymatic digestion which reduces contamination risk and manipulation time...
2016: Stem Cells International
A Rahmani, B Afandi
BACKGROUND: Gestational Diabetes Mellitus (GDM) is a common condition that affects pregnant women and may result in maternal as well as fetal and neonatal complications. Optimal coordinated management may reduce these complications if applied in team approach following generally accepted international guidelines. METHODS: A retrospective analysis of the neonatal outcomes of GDM mothers who were followed in a tertiary medical center in the United Arab Emirates. The aim of the study was to assess the efficacy of a comprehensive and multidisciplinary GDM program which was applied to a quality improvement project...
2015: Journal of Neonatal-perinatal Medicine
Ghasem Soltani, Amirmasoud Molkizadeh, Shahram Amini
BACKGROUND: Use of analgesics, especially opioids, before delivery during cesarean section for preventing hemodynamic changes after endotracheal intubation and postoperative analgesia is limited due to their adverse effects on the neonate. OBJECTIVES: The aim of this study was to investigate the effect of intravenous acetaminophen (paracetamol) in blunting hemodynamic responses to endotracheal intubation and postoperative pain in parturient undergoing cesarean section by general anesthesia...
December 2015: Anesthesiology and Pain Medicine
Sadic Kagwa, Mark A Hoeft, Paul G Firth, Stephen Ttendo, Vicki E Modest
BACKGROUND: Transversus abdominis plane (TAP) block provides 12-24 h of analgesia to the parietal peritoneum and abdominal wall, and are best used combined with oral or intravenous medications. Despite ease of use, a large margin of safety, and a high success rate, TAP blocks remain under used in settings where patients could most benefit from their use. Previous studies have used oral or intravenous narcotics for supplementation. However, the efficacy of TAP blocks in low-resourced settings where patients do not have dependable access to these medications is unknown...
April 27, 2015: Lancet
C Santoro, R Di Mauro, E Baldacci, F De Angelis, R Abbruzzese, F Barone, R A Bochicchio, G Ferrara, A Guarini, R Foà, M G Mazzucconi
Bleeding phenotype in factor XI (FXI)-deficient patients is variable, and not related to baseline FXI:Act. Aims of our study were to describe the characteristics and the management of surgery and deliveries in FXI-deficient patients, and to investigate the relationship between the haemorrhagic phenotype and the baseline FXI:Act. Ninety-five patients were diagnosed and followed in our centre for a median follow-up of 0.9 years (0.1-36.2); median FXI:Act of all patients: 38% (0.5-69%). Fifty-six patients (59%) experienced bleeding episodes not surgery-related...
July 2015: Haemophilia: the Official Journal of the World Federation of Hemophilia
John J McCarthy, Martin H Leamon, Neil H Willits, Ruth Salo
OBJECTIVES: To evaluate the effects of a multiple daily dose methadone regimen in pregnancy on neonatal outcomes. METHODS: Although methadone maintenance has been the standard for the treatment of opioid dependence in pregnancy, there is no consensus on proper dosing. Single daily dosing is the most common strategy. Because of accelerated metabolism of methadone in pregnancy, this regimen may expose mother and fetus to daily episodes of withdrawal and possibly contribute to more severe Neonatal Abstinence Syndrome (NAS)...
March 2015: Journal of Addiction Medicine
Ali Abood, Peter Vestergaard
OBJECTIVE: To study pregnancy and pregnancy outcomes in women with primary hyperparathyroidism (PHPT) and in controls. DESIGN: Register-based retrospective cohort study of women aged 16-44 years with a diagnosis of PHPT with age- and gender-matched non-exposed controls in Denmark. METHODS: The patients and controls were identified using the Danish National Hospital Discharge Register for the period 1977-2010. The outcomes were determined using the Birth Register, the Abortion Register and the LPR (National Hospital Discharge Register)...
July 2014: European Journal of Endocrinology
Innocent O George, Israel Jeremiah
BACKGROUND: Eclampsia is a leading cause of maternal and perinatal mortality in Nigeria. Preventive and interventional measures have been shown to reduce maternal mortality and morbidity with no significant beneficial effect on neonatal outcomes. The aim of this study is to assess the perinatal outcome of eclampsia at the University of Port-Harcourt Teaching Hospital (UPTH). MATERIALS AND METHODS: This prospective, cross-sectional study was conducted on 88 consecutive patients presenting with antepartum eclampsia at the UPTH between 1(st) January 2007 and 31(st) December 2008...
December 2009: International Journal of Biomedical Science: IJBS
Ejub Basic, Vesna Basic-Cetkovic, Hadzo Kozaric, Admir Rama
INTRODUCTION: The rate of attempted vaginal birth after previous cesarean delivery has decreased, while the success rate of such births increased. Advances in surgical techniques, the development of anesthesiology services, particularly endotracheal anesthesia, very quality postoperative care with cardiovascular, respiratory and biochemical resuscitation, significantly reduce maternal mortality and morbidity after cesarean section. Progress and development of neonatal services, and intensive care of newborns is enabled and a high survival of newborn infants...
September 2012: Acta Informatica Medica: AIM
Dorra Zeghal, Amira Ayachi, Sami Mahjoub, Ghassen Boulahya, Aymen Zakraoui, Rim Ben Hmid, Faouzia Zouari
AIM: To study the maternal and fetal morbidity in the association fibroid and pregnancy and the management in this case. METHODS: A retrospective study of 80 cases of fibroids associated to pregnancy. These cases were taken from the department "C" of gynecology and obstetrics in the center of maternity and neonatology of Tunis. RESULTS: We studied 80 cases of fibroid associated to pregnancy in our study. The mean age of the patients was 32 years old...
April 2012: La Tunisie Médicale
Siva Subramanian, Kathy S Katz, Margaret Rodan, Marie G Gantz, Nabil M El-Khorazaty, Allan Johnson, Jill Joseph
While biomedical risks contribute to poor pregnancy and neonatal outcomes in African American (AA) populations, behavioral and psychosocial risks (BPSR) may also play a part. Among low income AA women with psychosocial risks, this report addresses the impacts on pregnancy and neonatal outcomes of an integrated education and counseling intervention to reduce BPSR, as well as the contributions of other psychosocial and biomedical risks. Subjects were low income AA women ≥18 years living in the Washington, DC, metropolitan area and seeking prenatal care...
April 2012: Maternal and Child Health Journal
Patrycja J Puiman, Mikkel Jensen, Barbara Stoll, Ingrid B Renes, Adrianus C J M de Bruijn, Kristien Dorst, Henk Schierbeek, Mette Schmidt, Günther Boehm, Douglas G Burrin, Per T Sangild, Johannes B van Goudoever
Threonine is an essential amino acid necessary for synthesis of intestinal (glyco)proteins such as mucin MUC2 to maintain adequate gut barrier function. In premature infants, reduced barrier function may contribute to the development of necrotizing enterocolitis (NEC). Human milk protects against NEC compared with infant formula. Therefore, we hypothesized that formula feeding decreases the MUC2 synthesis rate concomitant with a decrease in intestinal first-pass threonine utilization, predisposing the preterm neonate to NEC...
July 2011: Journal of Nutrition
Peace I Opara, Tamunopriye Jaja, Uche C Onubogu
BACKGROUND: Infants born to diabetic women have certain distinctive characteristics, including large size and high morbidity risks. The neonatal mortality rate is over five times that of infants of non diabetic mothers and is higher at all gestational ages and birth weight for gestational age (GA) categories.The study aimed to determine morbidity and mortality pattern amongst infants of diabetic mothers (IDMS) admitted into the Special Care Baby Unit of University of Port Harcourt Teaching Hospital...
2010: Italian Journal of Pediatrics
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