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Mechanical obstetrics

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https://www.readbyqxmd.com/read/29904405/predictive-value-of-platelet-aggregation-rate-in-postpartum-deep-venous-thrombosis-and-its-possible-mechanism
#1
Mingxia Sun, Chongdong Liu, Na Zhao, Kaikai Meng, Zhenyu Zhang
The present study investigated the predictive value of the platelet aggregation rate in postpartum deep venous thrombosis and its possible mechanism. From January 2014 to January 2016, 23 patients with postpartum deep vein thrombosis of lower extremity treated in the Department of Obstetrics of Beijing Chaoyang Hospital were as assigned as the observation group. At the same time, 25 cases with normal recovery were assigned as the control group. Blood samples were collected from all the subjects. The platelet aggregation rate was measured using a platelet aggregation apparatus...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29902446/a-conceptual-framework-for-the-impact-of-obesity-on-risk-of-cesarean-delivery
#2
Anna Joy G Rogers, Lorie M Harper, Giancarlo Mari
Cesarean deliveries accounted for 32.2% of nearly 4 million births in the United States in 2014. Obesity affects a third of reproductive age women and is associated with worse cesarean delivery outcomes. Studies have shown that increasing maternal body mass index correlates linearly with cesarean delivery rates, but little is known about the potential mediating and moderating mechanisms. Thus, a conceptual framework for understanding how obesity correlates with risk of cesarean delivery is crucial to determining safe ways to reduce the cesarean delivery rate among obese gravidas...
June 11, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29894515/tolerogenic-%C3%AE-2-glycoprotein-i-dna-vaccine-and-fk506-as-an-adjuvant-attenuates-experimental-obstetric-antiphospholipid-syndrome
#3
Ya-Hsuan Chao, Der-Yuan Chen, Joung-Liang Lan, Kuo-Tung Tang, Chi-Chien Lin
DNA vaccines have recently emerged as a therapeutic agent for treating autoimmune diseases, such as multiple sclerosis. Antiphospholipid antibody syndrome (APS) is an autoimmune disease characterized by β2-glycoprotein I (β2-GPI)-targeting antiphospholipid antibodies (APAs) and vascular thrombosis or obstetrical complications. To examine the therapeutic potential of a β2-GPI DNA vaccine, we administered a vaccine mixed with FK506 as an adjuvant to a mouse model of obstetric APS. First, the pCMV3-β2-GPI DNA vaccine, which encodes the full-length human β2-GPI gene, was constructed...
2018: PloS One
https://www.readbyqxmd.com/read/29891914/obstetric-and-vascular-antiphospholipid-syndrome-same-antibodies-but-different-diseases
#4
REVIEW
Pier Luigi Meroni, Maria Orietta Borghi, Claudia Grossi, Cecilia Beatrice Chighizola, Paolo Durigutto, Francesco Tedesco
Recurrent thrombosis and miscarriages are the main clinical manifestations of antiphospholipid syndrome (APS). Although most patients display both clinical signs, some patients can have isolated vascular or obstetric variants. Emerging data raise the question of whether obstetric and vascular APS are the same or different diseases. An important difference between the two conditions is that a thrombophilic state is a common feature in vascular APS, whereas clot occlusions of the decidual spiral arteries are seldom observed in obstetric APS, and infarctions are found in only one-third of APS placentae...
June 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29880177/mechanical-induction-of-labor-and-ecbolic-less-vaginal-birth-after-cesarean-section-a-cohort-study
#5
Hytham Atia, Mohamed Ellaithy, Ahmed Altraigey, Mohamed Kolkailah, Amal Alserehi, Shabana Ashfaq
OBJECTIVE: During delivery counseling, some women with previous uncomplicated cesarean section (CS) wish mechanical induction of labor (IOL) but they are not accepting the added risk of using ecbolics to induce and/or augment labor. The objective of the study was to assess the safety and efficacy of the isolated use of transcervical Foley's catheter balloon as a mean of mechanical cervical ripening (CR)/IOL and successful ecbolic-less vaginal birth after cesarean section (VBAC). MATERIALS AND METHODS: A cohort study was conducted in two tertiary care maternity hospitals between October 2013 and July 2016 and recruited women with singleton pregnancy and cephalic presentation who had previous one uncomplicated CS and were scheduled for mechanical CR/IOL at term for routine obstetric indications...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29866726/can-india-s-primary-care-facilities-deliver-a-cross-sectional-assessment-of-the-indian-public-health-system-s-capacity-for-basic-delivery-and-newborn-services
#6
Jigyasa Sharma, Hannah H Leslie, Mathilda Regan, Devaki Nambiar, Margaret E Kruk
OBJECTIVES: To assess input and process capacity for basic delivery and newborn (intrapartum care hereafter) care in the Indian public health system and to describe differences in facility capacity between rural and urban areas and across states. DESIGN: Cross-sectional study. SETTING: Data from the nationally representative 2012-2014 District Level Household and Facility Survey, which includes a census of community health centres (CHC) and sample of primary health centres (PHC) across 30 states and union territories in India...
June 4, 2018: BMJ Open
https://www.readbyqxmd.com/read/29859118/-poverty-is-the-big-thing-exploring-financial-transportation-and-opportunity-costs-associated-with-fistula-management-and-repair-in-nigeria-and-uganda
#7
Kaji Tamanna Keya, Pooja Sripad, Emmanuel Nwala, Charlotte E Warren
BACKGROUND: Women living with obstetric fistula often live in poverty and in remote areas far from hospitals offering surgical repair. These women and their families face a range of costs while accessing fistula repair, some of which include: management of their condition, lost productivity and time, and transport to facilities. This study explores, through women's, communities', and providers' perspectives, the financial, transport, and opportunity cost barriers and enabling factors for seeking repair services...
June 1, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29848449/biological-versus-mechanical-heart-valve-prosthesis-during-pregnancy-in-women-with-congenital-heart-disease
#8
Heleen Lameijer, Ymkje J van Slooten, Monique R M Jongbloed, Martijn A Oudijk, Marlies A M Kampman, Arie P van Dijk, Marco C Post, Barbara J Mulder, Krystyna M Sollie, Dirk J van Veldhuisen, Tjark Ebels, Joost P van Melle, Petronella G Pieper
BACKGROUND: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease. METHODS: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV. RESULTS: 52 women had 102 pregnancies of which 78 pregnancies (46 women) ≥20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19, ≤20 weeks) occurred more frequently in women using anticoagulation (P < ...
May 23, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29809179/-obstetric-emergencies-and-non-emergencies-at-central-military-hospital-i-our-vision-and-the-epidemiologic-horizon
#9
Luis M García-Núñez, Juan A Ramos-Martínez, Irving I Morales-Pogoda, Martín Fuentes-Durán, Edgar F Hernández-García, Raúl García-Ramírez
Background: Maternal morbidity and mortality pose a significant impact on national public health, being medical attention of obstetric emergencies (OE) and non-emergencies (ONE) of capital importance. Methods: Descriptive and epidemiologic analysis of OE/ONE at a 3rd level military echelon. Results: During a 34-months span, 48 patients were approached at the emergency department (1.4 admissions/month). Mean age: 29 ± 3 years (17-41). Eight patients (17%) were considered OE and 40 (83%) ONE...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29807015/mir-199b-5p-promotes-tumor-growth-and-metastasis-in-cervical-cancer-by-down-regulating-klk10
#10
Li-Juan Xu, Yu Duan, Peng Wang, Hui-Qing Yin
MiR-199 b-5p and kallikrein-related peptidase 10 (KLK10) are related to various disease processes and pathogenesis. However, little is known about the molecular mechanisms of miR-199 b-5p and KLK10 in human cervical cancer. In the present study, we found that miR-199 b-5p was highly expressed in cervical cancer tissues and cell lines, and was positively correlated with overall survival (OS) and progression-free survival (PFS), higher incidences of larger tumor sizes, late International Federation of Gynecology and Obstetrics (FIGO) stages and preoperative metastasis...
May 25, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29797147/associations-between-latent-classes-of-interpersonal-polyvictimization-and-polyperpetration-and-sexual-risk-behaviors-among-young-pregnant-couples-a-dyadic-analysis
#11
Tiara Willie, Trace S Kershaw
Interpersonal violence victimization and perpetration have been associated with sexual risk behaviors among adolescents and young adults, but research is lacking on: (1) how patterns of interpersonal polyvictimization and polyperpetration are associated with sexual risk among young pregnant couples, and (2) how individual and partner experiences of violence differentially impact sexual risk. The current analyses used baseline data from a longitudinal study that followed 296 pregnant young couples from pregnancy to 12 months postpartum...
May 24, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29781876/postpartum-pain-management
#12
(no author information available yet)
Pain and fatigue are the most common problems reported by women in the early postpartum period. Pain can interfere with a woman's ability to care for herself and her infant. Untreated pain is associated with a risk of greater opioid use, postpartum depression, and development of persistent pain. Nonpharmacologic and pharmacologic therapies are important components of postpartum pain management. Because 81% of women in the United States initiate breastfeeding during the postpartum period, it is important to consider the drug effects of all prescribed medications on the mother-infant dyad...
May 17, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29753684/first-time-mothers-birth-beliefs-preferences-and-actual-birth-a-longitudinal-observational-study
#13
Heidi Preis, Michal Eisner, Rony Chen, Yael Benyamini
PROBLEM: Birth preferences, such as mode and place of birth and other birth options, have important individual and societal implications, yet few studies have investigated the mechanism which predicts a wide range of childbirth options simultaneously. BACKGROUND: Basic beliefs about birth as a natural and as a medical process are both predictive factors for childbirth preferences. Studies investigating birth beliefs, preferences, and actual birth are rare. AIM: To test a predictive model of how these beliefs translate into birth preferences and into actual birth related-options...
May 9, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29752225/mindfulness-based-programme-on-the-psychological-health-of-pregnant-women
#14
Wan-Lin Pan, Meei-Ling Gau, Tzu-Ying Lee, Hei-Jen Jou, Chieh-Yu Liu, Tzung-Kuen Wen
PROBLEM: Preparation of psychological well-being is an important component of antenatal education for childbirth, but few courses focus on this component. BACKGROUND: The psychosocial health of pregnant women is known to affect perinatal outcomes. Psychosocial stress in women has been associated with increased obstetric interventions and has been shown to affect the health of both mother and child. AIM: To explore the efficacy of an eight-week Mindfulness-Based Childbirth and Parenting programme on reducing prenatal stress, depression, mindfulness, and childbirth self-efficacy...
May 8, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29741988/a-dynamic-compliance-cervix-phantom-robot-for-latent-labor-simulation
#15
Michelle Jennifer Luk, Derek Lobb, James Andrew Smith
Physical simulation systems are commonly used in training of midwifery and obstetrics students, but none of these systems offers a dynamic compliance aspect that would make them more truly representative of cervix ripening. In this study, we introduce a unique soft robot phantom that simulates the cervix softening during the latent labor phase of birth. This proof-of-concept robotic phantom can be dilated by 1 cm and effaced by 35% through the application of a Foley catheter-like loading mechanism. Furthermore, psychophysics trials demonstrate how untrained subjects can identify hard and soft states of the phantom with specificities of 91% and 87%, respectively...
May 9, 2018: Soft Robotics
https://www.readbyqxmd.com/read/29739262/comparison-of-prostaglandin-and-mechanical-cervical-ripening-in-the-setting-of-small-for-gestational-age-neonates
#16
Robert M Rossi, Carri R Warshak, Heather R Masters, Jodi K Regan, Sara A Kritzer, Kristin P Magner
OBJECTIVE: To determine whether cervical ripening with misoprostol (MP) is associated with higher rates of cesarean delivery (CD) (CD) compared to dinoprostone (DP) or Pitocin/Foley balloon (PFB) in infants found to be small for gestational age (SGA). STUDY DESIGN: Single center institution based cohort study of all inductions between 2008-2012 where birth weight was found to be as SGA (< 10th percentile). Maternal demographic, obstetric, and labor characteristics were compared between SGA births where cervical ripening with MP, Mode compares MP to referent group (DP), or PFB was used as the primary agent...
May 8, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29730689/right-heart-dilatation-in-a-fetus-with-an-abnormal-foramen-ovale-valve-an-indicator-of-interatrial-communication-restriction
#17
Wenjia Lei, Miao Fan, Meilian Wang, Yu Wang, Wei Sun, Xue Sun, Ying Zhang
AIMS: Foramen ovale (FO) valve with a shape or motion abnormality is frequently detected during routine obstetric ultrasonic examinations. However, the hemodynamics mechanism of this entity remains unclear. The purpose of the study is to determine the relevance of interatrial communication restriction and resultant morphological modifications. MATERIALS AND METHODS: We reviewed the echocardiographic records of fetuses with isolated abnormal FO valve evaluated between January of 2010 and december of 2016...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29709093/magnesium-sulfate-differentially-modulates-fetal-membrane-inflammation-in-a-time-dependent-manner
#18
Sarah N Cross, Rachel A Nelson, Julie A Potter, Errol R Norwitz, Vikki M Abrahams
PROBLEM: Chorioamnionitis and infection-associated inflammation are major causes of preterm birth. Magnesium sulfate (MgSO4 ) is widely used in obstetrics as a tocolytic; however, its mechanism of action is unclear. This study sought to investigate how MgSO4 modulates infection-associated inflammation in fetal membranes (FMs), and whether the response was time dependent. METHOD OF STUDY: Human FM explants were treated with or without bacterial lipopolysaccharide (LPS); with or without MgSO4 added either: 1 hour before LPS; at the same time as LPS; 1 hour post-LPS; or 2 hours post-LPS...
April 30, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29687161/obstetric-patients-perspectives-on-functional-magnetic-neuroimaging-research-in-pregnant-women
#19
Rebecca L Newmark, Michelle L Zaydlin, Amy Yang, Kelcie Kuchenrither, Katherine L Wisner, Suena H Massey
Magnetic resonance neuroimaging (MRI) studies of healthy pregnant women could identify key mechanisms of spontaneous health behavior changes observed in expectant mothers as novel intervention targets, but are currently unprecedented. As balancing potential benefits of research with unknown risks, including participant perceptions of risk, is foundational to ethical conduct, we surveyed a convenience obstetric sample to understand pregnant women's perspectives on this issue. Respondents were 76 pregnant women (modal age of 30-39 years; 64% multiparous) presenting for obstetric care from April to June 2016 at privately and publicly funded clinics at an urban academic medical center in the Midwestern USA...
April 23, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29666409/exposure-to-phthalate-an-endocrine-disrupting-chemical-alters-the-first-trimester-placental-methylome-and-transcriptome-in-women
#20
N M Grindler, L Vanderlinden, R Karthikraj, K Kannan, S Teal, A J Polotsky, T L Powell, I V Yang, T Jansson
Phthalates are known endocrine disruptors and associated with decreased fecundity, pregnancy loss, and adverse obstetrical outcomes, however the underlying mechanisms remain to be established. Environmental factors can influence gene expression and cell function by modifying epigenetic marks, impacting the developing embryo as well as future generations of offspring. The impact of phthalates on placental gene methylation and expression is largely unknown. We studied the effect of maternal phthalate exposure on the human placental DNA methylome and transcriptome...
April 17, 2018: Scientific Reports
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