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Mechanical obstetrics

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https://www.readbyqxmd.com/read/27899965/increased-expression-of-long-non-coding-rna-xist-predicts-favorable-prognosis-of-cervical-squamous-cell-carcinoma-subsequent-to-definitive-chemoradiation-therapy
#1
Reiko Kobayashi, Ryu Miyagawa, Hideomi Yamashita, Teppei Morikawa, Kae Okuma, Masashi Fukayama, Kuni Ohtomo, Keiichi Nakagawa
The present retrospective study aimed to examine the association between the expression of long non-protein-coding RNAs (lncRNAs) and clinical prognosis in the pretreatment formalin-fixed, paraffin-embedded (FFPE) tissue samples of cervical squamous cell carcinoma patients that underwent platinum-based chemoradiation therapy. Between 2001 and 2013, 49 consecutive patients with squamous cell cervical carcinoma were selected for the present study (median follow-up period, 44.1 months). The patients possessed an International Federation of Gynecology and Obstetrics stage of IB1/IIA1 (with pelvic lymph node metastasis), IB2 or IIA2-IVA, and had been treated with definitive chemoradiation therapy...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27826776/development-of-a-novel-simulation-model-for-assessment-of-laparoscopic-camera-navigation
#2
Melissa W Brackmann, Pamela Andreatta, Karen McLean, R Kevin Reynolds
BACKGROUND: Laparoscopic camera navigation is vital to laparoscopic surgery, yet often falls to the most junior member of the surgical team who has limited laparoscopic operating experience. Previously published reports on simulation models fail to address qualitative scoring of movement, method of communication and correct physician location with respect to patient position. The purpose of this study was to develop and evaluate a novel laparoscopic camera navigation simulation model that addresses these deficiencies...
November 8, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27821151/-i-ve-changed-my-mind-mindfulness-based-childbirth-and-parenting-mbcp-for-pregnant-women-with-a-high-level-of-fear-of-childbirth-and-their-partners-study-protocol-of-the-quasi-experimental-controlled-trial
#3
Irena K Veringa, Esther I de Bruin, Nancy Bardacke, Larissa G Duncan, Francisca J A van Steensel, Carmen D Dirksen, Susan M Bögels
BACKGROUND: Approximately 25 % of pregnant women suffer from a high level of Fear of Childbirth (FoC), as assessed by the Wijma Delivery Expectancy Questionnaire (W-DEQ-A, score ≥66). FoC negatively affects pregnant women's mental health and adaptation to the perinatal period. Mindfulness-Based Childbirth and Parenting (MBCP) seems to be potentially effective in decreasing pregnancy-related anxiety and stress. We propose a theoretical model of Avoidance and Participation in Pregnancy, Birth and the Postpartum Period in order to explore FoC and to evaluate the underlying mechanisms of change of MBCP...
November 7, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27816832/the-nature-of-early-stage-endometrial-cancer-recurrence-a-national-cohort-study
#4
Mette Moustgaard Jeppesen, Pernille Tine Jensen, Dorte Gilså Hansen, Maria Iachina, Ole Mogensen
BACKGROUND AND AIMS: The aim of the study was to present a comprehensive analysis of disease recurrence in a large Danish cohort of women with early-stage endometrial cancer treated according to national guidelines. METHODS: All women diagnosed with stage I or II endometrial cancer in 2005-2009 were included in a population-based historical cohort derived from the Danish Gynaecological Cancer Database. Disease recurrence up to 3 years after the primary diagnosis was identified using national registers and hospital charts...
November 3, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27816161/trauma-and-considerations-unique-to-pregnancy
#5
REVIEW
Christy Pearce, Stephanie R Martin
Trauma complicates 6% to 7% of all pregnancies and requires multidisciplinary education and training for both trauma and obstetric teams to achieve the best outcome. It is important to understand the mechanisms of certain adverse maternal and fetal/neonatal outcomes incurred as a result of trauma, as well as caveats to pregnancy physiology that make some injuries more likely and detection of maternal compromise more difficult. This article focuses on these caveats and how to incorporate these into ongoing trauma protocols and offers suggestions for the formation of obstetric trauma response team...
December 2016: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/27812724/responding-to-maternal-distress-from-needs-assessment-to-effective-intervention
#6
Yvonne Fontein-Kuipers, Evelien van Limbeek, Marlein Ausems, Raymond de Vries, Marianne Nieuwenhuijze
OBJECTIVES: To perform a needs assessment of maternal distress to plan the development of an intervention for the prevention and reduction of antenatal maternal distress. METHODS: We searched PubMed, OVID and EBSCO and applied the PRECEDE logic model to select the data. Experts in the field validated the findings. RESULTS: We identified 45 studies. Maternal distress was associated with diminished maternal and child's quality of life. Aetiological factors of maternal distress included past and present circumstances related to obstetric factors and to a woman's context of living, coping behaviour, and support mechanisms...
November 3, 2016: International Journal of Public Health
https://www.readbyqxmd.com/read/27789185/increased-miscarriage-of-euploid-pregnancies-in-obese-women-undergoing-cryopreserved-embryo-transfer
#7
Kelton Tremellen, Karma Pearce, Deidre Zander-Fox
Obesity is known to be associated with an increased risk of miscarriage after natural and assisted conception. Although most sporadic miscarriages are caused by genetic abnormalities, it is presently uncertain if genetics is also the underlying mechanism leading to increased pregnancy loss seen in obese women. Karyotyping of the products of conception suggests a reduced rate of fetal aneuploidy in miscarriages from obese compared with lean individuals. Karyotype analysis, however, is prone to false negative results because of inadvertent culture of maternal rather than fetal tissue...
October 17, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27773528/antenatal-maternity-leave-and-childbirth-using-the-first-baby-study-a-propensity-score-analysis
#8
Julia M Goodman, Sylvia Guendelman, Kristen H Kjerulff
BACKGROUND: Most employed American women work during pregnancy and continue working through the month they deliver. Yet, few studies estimate the relationship between maternity leave taken during pregnancy and maternal health. We evaluate the association of antenatal leave (ANL) uptake with obstetric outcomes, assessing the potential role of protective and adverse selection pathways on this relationship. METHODS: We sample 1,740 employed women who delivered at term from the First Baby Study, a prospective cohort of nulliparous women in Pennsylvania...
October 20, 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/27770218/3d-cell-culturing-and-possibilities-for-myometrial-tissue-engineering
#9
Minoo Heidari Kani, Eng-Cheng Chan, Roger C Young, Trent Butler, Roger Smith, Jonathan W Paul
Research insights into uterine function and the mechanisms of labour have been hindered by the lack of suitable animal and cellular models. The use of traditional culturing methods limits the exploration of complex uterine functions, such as cell interactions, connectivity and contractile behaviour, as it fails to mimic the three-dimensional (3D) nature of uterine cell interactions in vivo. Animal models are an option, however, use of these models is constrained by ethical considerations as well as translational limitations to humans...
October 21, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27753936/os-06-01-developmental-stages-of-hypertension-between-males-and-females-are-there-different-mechanisms
#10
Abdullah Mamun
OBJECTIVE: The objectives of this study are to investigate the developmental stages of hypertension between males and females and identify why young males have higher blood pressure than young females. DESIGN AND METHOD: The study used a sub-sample of 2000 offspring from the original cohort of the Mater University of Queensland Study of Pregnancy (MUSP) and its outcomes. The MUSP is a prospective birth cohort study which commenced in early 1980 s in Brisbane, Australia and followed their offspring till young adulthood...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27751799/performance-of-the-obstetric-early-warning-score-in-critically-ill-patients-for-the-prediction-of-maternal-death
#11
Angel Paternina-Caicedo, Jezid Miranda, Ghada Bourjeily, Andrew Levinson, Carmelo Dueñas, Camilo Bello Muñoz, José A Rojas-Suarez
BACKGROUND: Every day, about 830 women die worldwide from preventable causes related to pregnancy and childbirth. Obstetric early-warning scores have been proposed as a potential tool to reduce maternal morbidity and mortality, based upon the identification of predetermined abnormal values in the vital signs or laboratory parameters, to generate a rapid and effective medical response. Several early-warning scores have been developed for obstetrical patients, but the majority are the result of a clinical consensus rather than statistical analyses of clinical outcome measures (i...
October 14, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27734711/findings-and-differential-diagnosis-of-fetal-intracranial-hemorrhage-and-fetal-ischemic-brain-injury-what-is-the-role-of-fetal-mri
#12
Bryn Putbrese, Anne Kennedy
Ventriculomegaly (VM) is a nonspecific finding on fetal imaging. Identification of the specific etiology is important as it affects prognosis and may even change the course of current or future pregnancies. In this review we will focus on the application of fetal MRI to demonstrate intracranial hemorrhage (ICH) and ischemic brain injury as opposed to other causes of VM. MRI is able to identify the specific etiology of ventriculomegaly with much more sensitivity and specificity than ultrasound and should be considered whenever VM is identified on obstetric ultrasound...
October 13, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27706532/optimal-anticoagulation-for-pregnant-women-with-mechanical-heart-valves
#13
Rohan D'Souza, Candice K Silversides, Claire McLintock
The prothrombotic state of pregnancy increases the risk of thromboembolic complications and death in women with mechanical heart valves (MHVs). Although it is accepted that these women must be on therapeutic anticoagulation throughout pregnancy, competing maternal and fetal risks, as well as the lack of high-quality data from prospective studies, make the choice of the optimal method of anticoagulation challenging. Vitamin K antagonists (VKAs) are associated with fewer maternal complications, but conversely also the lowest live birth rates as well as warfarin-related embryopathy and fetopathy...
October 5, 2016: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/27687243/measuring-maternal-mortality-using-a-reproductive-age-mortality-study-ramos
#14
Florence Mgawadere, Regine Unkels, Adetoro Adegoke, Nynke van den Broek
BACKGROUND: Assessing the feasibility of conducting a prospective Reproductive Age Mortality Survey (RAMOS) study in the low-income setting of Mangochi District, Malawi to obtain cotemporaneous estimates of the number, cause of and conditions associated with maternal deaths (MD) in all women of reproductive age (WRA) (n = 207 688). METHODS: MD among all deaths of WRA were identified using the ICD-10 definition. Cause of death and contributing conditions identified by a panel of experts using the classification system for deaths during pregnancy, childbirth and puerperium (ICD-MM)...
September 29, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27651750/how-pregnancy-can-affect-autoimmune-diseases-progression
#15
REVIEW
Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Paola Parronchi, Sergio Romagnani
Autoimmune disorders are characterized by tissue damage, caused by self-reactivity of different effectors mechanisms of the immune system, namely antibodies and T cells. Their occurrence may be associated with genetic and/or environmental predisposition and to some extent, have implications for fertility and obstetrics. The relationship between autoimmunity and reproduction is bidirectional. This review only addresses the impact of pregnancy on autoimmune diseases and not the influence of autoimmunity on pregnancy development...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27649091/european-consensus-guidelines-on-the-management-of-respiratory-distress-syndrome-2016-update
#16
David G Sweet, Virgilio Carnielli, Gorm Greisen, Mikko Hallman, Eren Ozek, Richard Plavka, Ola Didrik Saugstad, Umberto Simeoni, Christian P Speer, Máximo Vento, Gerard H A Visser, Henry L Halliday
Advances in the management of respiratory distress syndrome (RDS) ensure that clinicians must continue to revise current practice. We report the third update of the European Guidelines for the Management of RDS by a European panel of expert neonatologists including input from an expert perinatal obstetrician based on available literature up to the beginning of 2016. Optimizing the outcome for babies with RDS includes consideration of when to use antenatal steroids, and good obstetric practice includes methods of predicting the risk of preterm delivery and also consideration of whether transfer to a perinatal centre is necessary and safe...
September 21, 2016: Neonatology
https://www.readbyqxmd.com/read/27643331/os-06-01-developmental-stages-of-hypertension-between-males-and-females-are-there-different-mechanisms
#17
Abdullah Mamun
OBJECTIVE: The objectives of this study are to investigate the developmental stages of hypertension between males and females and identify why young males have higher blood pressure than young females. DESIGN AND METHOD: The study used a sub-sample of 2000 offspring from the original cohort of the Mater University of Queensland Study of Pregnancy (MUSP) and its outcomes. The MUSP is a prospective birth cohort study which commenced in early 1980 s in Brisbane, Australia and followed their offspring till young adulthood...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27636577/national-partnership-for-maternal-safety-consensus-bundle-on-venous-thromboembolism
#18
Mary E D'Alton, Alexander M Friedman, Richard M Smiley, Douglas M Montgomery, Michael J Paidas, Robyn D'Oria, Jennifer L Frost, Afshan B Hameed, Deborah Karsnitz, Barbara S Levy, Steven L Clark
Obstetric venous thromboembolism is a leading cause of severe maternal morbidity and mortality. Maternal death from thromboembolism is amenable to prevention, and thromboprophylaxis is the most readily implementable means of systematically reducing the maternal death rate. Observational data support the benefit of risk-factor-based prophylaxis in reducing obstetric thromboembolism. This bundle, developed by a multidisciplinary working group and published by the National Partnership for Maternal Safety under the guidance of the Council on Patient Safety in Women's Health Care, supports routine thromboembolism risk assessment for obstetric patients, with appropriate use of pharmacologic and mechanical thromboprophylaxis...
October 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27631133/antibodies-directed-against-annexin-a2-and-obstetric-morbidity
#19
V Salle, J Schmidt, A Smail, C Mazière, M A Conte, A Brulé, J C Mazière, E Cadet, Y E Herpe, P Duhaut
Acquired and inherited thrombophilia have both been reported to be associated with an increased risk of obstetric complications in early or later stages of pregnancy. Annexin A2 (ANXA2) is strongly expressed in vascular and placental tissues and plays a crucial role in fibrinolysis. The aim of the present study was to evaluate the prevalence of antibodies directed against ANXA2 in patients with recurrent miscarriage or obstetric complications. Anti-ANXA2 antibodies (aANXA2) were detected by ELISA in the sera from 46 women with obstetric morbidity, mainly recurrent miscarriage...
August 30, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27629132/posture-and-low-back-pain-during-pregnancy-3d-study
#20
Wojciech M Glinkowski, Paweł Tomasik, Katarzyna Walesiak, Michał Głuszak, Karolina Krawczak, Jakub Michoński, Anna Czyżewska, Agnieszka Żukowska, Robert Sitnik, Mirosław Wielgoś
OBJECTIVES: Back pain is a common complaint of pregnant women. The posture, curvatures of the spine and the center of gravity changes are considered as the mechanisms leading to pain. The study aimed to assess spinal curvatures and static postural characteristics with three-dimensional surface topography and search for relationships with the occurrence of back pain complaints among pregnant women. MATERIAL AND METHODS: The study was conducted from December 2012 to February 2014...
2016: Ginekologia Polska
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