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https://www.readbyqxmd.com/read/29149460/the-impact-of-a-prolonged-stay-in-the-icu-on-patients-fundamental-care-needs
#1
Claire Minton, Lesley Batten, Annette Huntington
AIM: To explore patients', families', and health professionals' experiences of a long-stay patient in an intensive care unit. BACKGROUND: The fast-paced technologically driven intensive care unit environment, designed for a short patient stay, supports the provision of complex physiologically-focused care for those with life-threatening illnesses. Long stay patients with pronounced fundamental care needs fall outside predicted patient pathways, and nurses can find caring for these patients challenging...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29133182/a-novel-method-for-localization-and-ablation-of-conduction-gaps-after-wide-antral-circumferential-ablation-of-pulmonary-veins
#2
Raoul Bacquelin, Raphaël P Martins, Nathalie Behar, Vincent Galand, Baptiste Polin, Jonathan Lacaze, Frédéric Sebag, Christophe Leclercq, Jean-Claude Daubert, Philippe Mabo, Dominique Pavin
BACKGROUND: Atrial fibrillation ablation is often performed by achieving pulmonary vein isolation using the "wide antral circumferential ablation" (WACA) technique, but many pulmonary veins remain connected because of conduction gaps in the ablation line. AIM: To analyse the efficacy of a novel technique based on pacing manoeuvres to detect gaps in an initial WACA lesion. METHODS: Patients referred for radiofrequency atrial fibrillation ablation were enrolled prospectively...
November 10, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29104543/simultaneous-quantification-of-spatially-discordant-alternans-in-voltage-and-intracellular-calcium-in-langendorff-perfused-rabbit-hearts-and-inconsistencies-with-models-of-cardiac-action-potentials-and-ca-transients
#3
Ilija Uzelac, Yanyan C Ji, Daniel Hornung, Johannes Schröder-Scheteling, Stefan Luther, Richard A Gray, Elizabeth M Cherry, Flavio H Fenton
Rationale: Discordant alternans, a phenomenon in which the action potential duration (APDs) and/or intracellular calcium transient durations (CaDs) in different spatial regions of cardiac tissue are out of phase, present a dynamical instability for complex spatial dispersion that can be associated with long-QT syndrome (LQTS) and the initiation of reentrant arrhythmias. Because the use of numerical simulations to investigate arrhythmic effects, such as acquired LQTS by drugs is beginning to be studied by the FDA, it is crucial to validate mathematical models that may be used during this process...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29096073/a-primer-on-concepts-and-applications-of-proteomics-in-neuroscience
#4
REVIEW
Fabian Hosp, Matthias Mann
The enormous complexity of the central nervous system has impeded its systemic exploration for decades but powerful "omic" technologies are now pushing forward the frontiers of neuroscience research at an increasing pace. This Primer reviews the most recent progress in mass spectrometry (MS)-based proteomics, focusing on the analysis of whole proteomes, protein-based interactions, and post-translational modifications. We also discuss how advanced workflows help to unravel spatial, regulatory, and temporal aspects of neuronal systems...
November 1, 2017: Neuron
https://www.readbyqxmd.com/read/29094471/antifibrillatory-effects-of-renal-denervation-on-ventricular-fibrillation-in-a-canine-model-of-pacing-induced-heart-failure
#5
Qingzhi Luo, Qi Jin, Ning Zhang, Shangwei Huang, Yanxin Han, Changjian Lin, Tianyou Ling, Kang Chen, Wenqi Pan, Liqun Wu
This study investigated the effects of renal denervation (RDN) on vulnerability to ventricular fibrillation (VF) and ventricular electrical properties in a canine model of pacing-induced heart failure (HF). Eighteen beagles were divided into the following three groups: control (n = 6), HF (n = 6) and HF+RDN (n = 6). HF was induced by rapid right ventricular pacing. RDN was performed simultaneously with the pacemaker implantation in the HF+RDN group. A 64-unipolar basket catheter was used to perform global endocardial mapping of the left ventricle...
November 2, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29093537/perceptual-integration-and-attention-in-human-extrastriate-cortex
#6
Francesca Strappini, Gaspare Galati, Marialuisa Martelli, Enrico Di Pace, Sabrina Pitzalis
Visual crowding is a perceptual phenomenon with far-reaching implications in both perceptual (e.g., object recognition and reading) and clinical (e.g., developmental dyslexia and visual agnosia) domains. Here, we combined event-related fMRI measurements and wide-field brain mapping methods to investigate whether the BOLD response evoked by visual crowding is modulated by different attentional conditions. Participants underwent two sessions of psychophysical training outside the scanner, and then fMRI BOLD activity was measured simultaneously in early visual areas (including the visual word form area, VWFA), while they viewed strongly-crowded and weakly-crowded Gabor patches in attended and unattended conditions...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29092036/antegrade-transseptal-approach-for-left-ventricular-tachyarrhythmia-in-patients-with-previous-mitraclip-implantation
#7
Kentaro Hayashi, Christian-H Heeger, Shibu Mathew, Tilman Maurer, Christine Lemes, Johannes Riedl, Bruno Reißmann, Christian Frerker, Stephan Geidel, Michael Schmoeckel, Ardan M Saguner, Francesco Santoro, Roland Richard Tilz, Andreas Metzner, Karl-Heinz Kuck, Feifan Ouyang
Aims: Antegrade-transseptal approach to treat left ventricular tachyarrhythmia (LVT) is useful and widespread. Meanwhile, Mitraclip has been recently introduced as an alternative to mitral valve surgery for severe mitral regurgitation, usually coexisting with ventricular arrhythmias. However, data on the antegrade approach for mapping and ablating LVT in these patients are insufficient. We evaluated the feasibility and clinical impact of the antegrade approach for LVT after Mitraclip implantation...
October 30, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29089483/three-dimensional-scanless-holographic-optogenetics-with-temporal-focusing-3d-shot
#8
Nicolas C Pégard, Alan R Mardinly, Ian Antón Oldenburg, Savitha Sridharan, Laura Waller, Hillel Adesnik
Optical methods capable of manipulating neural activity with cellular resolution and millisecond precision in three dimensions will accelerate the pace of neuroscience research. Existing approaches for targeting individual neurons, however, fall short of these requirements. Here we present a new multiphoton photo-excitation method, termed three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT), which allows precise, simultaneous photo-activation of arbitrary sets of neurons anywhere within the addressable volume of a microscope...
October 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/29081398/high-resolution-mapping-of-the-triangle-of-koch-spatial-heterogeneity-of-fast-pathway-atrionodal-connections
#9
Kelvin Chua, Gaurav Upadhyay, Elliot Lee, Zaid Aziz, Andrew Beaser, Cevher Ozcan, Michael Broman, Hemal Nayak, Roderick Tung
BACKGROUND: Prior dedicated mapping studies of the triangle of Koch to characterize retrograde fast pathway activation have not been performed using high-resolution, three-dimensional, multielectrode mapping technology. OBJECTIVE: To delineate the activation pattern and spatial distribution of the retrograde fast pathway within the triangle of Koch during typical AVNRT and right ventricular pacing in a consecutive series of patients using the Rhythmia mapping system...
October 25, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29072996/wide-qrs-tachycardia-in-a-patient-with-pre-excitation-what-are-the-pathways-involved-pacing-manoeuvres-to-characterize-a-unique-pathway
#10
Krishna Kumar Mohanan Nair, Anees Thajudeen, Narayanan Namboodiri, Ajitkumar Valaparambil
A 30year old patient presented to us with recurrent episodes of palpitation and documented tachycardia. In all his presentations a wide QRS tachycardia was recorded. The baseline ECG showed pre excitation. The 12 lead ECG of the tachycardia and the baseline ECG is shown in Fig. 1A. During EP study the patient had baseline pre excitation and the HV interval was 16 ms. A duo-decapolar halo (HL) catheter was used to map right atrium and a decapolar coronary sinus (CS) catheter was used to map coronary sinus...
March 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29067911/syncope-in-a-young-man-role-of-purkinje-fibres-in-idiopathic-ventricular-fibrillation
#11
Claire A Martin, Laurence Nunn, Pier D Lambiase
A young man suffered cardiac arrests with polymorphic ventricular tachycardia (PVT) and ventricular fibrillation (VF) triggered by ventricular premature contractions (PVCs). The arrhythmia was resistant to anti-arrhythmics, so after ICD implantation he underwent successful ablation of the triggering VE beat, which was pace-mapped to the left posterior hemi-fascicle. We review the evidence for the role of the Purkinje network in the initiation and maintenance of PVT and VF, postulating a channelopathy as a possible underlying cause, and provide recommendations for PVC ablation...
July 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29064041/does-cardiac-resynchronization-therapy-benefit-patients-with-non-left-bundle-branch-block-prolonged-qrs-patterns
#12
REVIEW
Mark N Belkin, Gaurav A Upadhyay
PURPOSE OF REVIEW: We sought to assess the utility of CRT in patients with non-LBBB. RECENT FINDINGS: CRT has an established role as a device-based therapy for patients with HF with systolic dysfunction and intraventricular conduction disease, specifically LBBB. In modern practice, the use of CRT in non-LBBB patients remains controversial, with high rates of non-response for CRT in patients with RBBB, in particular. Recent studies have identified sub-populations of non-LBBB patients that respond to resynchronization, such as those with prolonged PR intervals (≥ 230 ms), with RBBB and concomitant left-sided delay and those with significant burden of right ventricular pacing...
October 24, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/29047005/identification-of-valve-related-artifact-during-cardiac-mapping
#13
Krishna Kancharla, Thomas M Munger, Rick A Nishimura, Abhishek Deshmukh, Douglas L Packer, Samuel J Asirvatham, Suraj Kapa
PURPOSE: During cardiac mapping, it is critical to discriminate signals related to cardiac conduction versus those due to mechanical interaction with other cardiac structures such as valves. We sought to define characteristics that could facilitate discrimination of valve artifact from cardiac conduction signals. METHODS: Patients with structurally normal heart undergoing mapping for ventricular arrhythmias arising from the vicinity of the aortic valve between January 2013 and May 2015 were included...
October 18, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29024171/demonstration-of-a-long-narrow-critical-isthmus-of-ischemic-ventricular-tachycardia-by-pace-mapping
#14
Takumi Yamada, Taihei Itoh, G Neal Kay
No abstract text is available yet for this article.
October 11, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28974620/time-resolved-transposon-insertion-sequencing-reveals-genome-wide-fitness-dynamics-during-infection
#15
Guanhua Yang, Gabriel Billings, Troy P Hubbard, Joseph S Park, Ka Yin Leung, Qin Liu, Brigid M Davis, Yuanxing Zhang, Qiyao Wang, Matthew K Waldor
Transposon insertion sequencing (TIS) is a powerful high-throughput genetic technique that is transforming functional genomics in prokaryotes, because it enables genome-wide mapping of the determinants of fitness. However, current approaches for analyzing TIS data assume that selective pressures are constant over time and thus do not yield information regarding changes in the genetic requirements for growth in dynamic environments (e.g., during infection). Here, we describe structured analysis of TIS data collected as a time series, termed pattern analysis of conditional essentiality (PACE)...
October 3, 2017: MBio
https://www.readbyqxmd.com/read/28968706/linkagemapview-rendering-high-resolution-linkage-and-qtl-maps
#16
Lisa A Ouellette, Robert W Reid, Steven G Blanchard, Cory R Brouwer
Motivation: Linkage and quantitative trait loci (QTL) maps are critical tools for the study of the genetic basis of complex traits. With the advances in sequencing technology over the past decade, linkage map densities have been increasing dramatically, while the visualization tools have not kept pace. LinkageMapView is a free add-on package written in R that produces high resolution, publication-ready visualizations of linkage and QTL maps. While there is software available to generate linkage map graphics, none are freely available, produce publication quality figures, are open source and can run on all platforms...
September 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28966986/intra-atrial-conduction-delay-revealed-by-multisite-incremental-atrial-pacing-is-an-independent-marker-of-remodeling-in-human-atrial-fibrillation
#17
Steven E Williams, Nick W F Linton, James Harrison, Henry Chubb, John Whitaker, Jaswinder Gill, Christopher A Rinaldi, Reza Razavi, Steven Niederer, Matthew Wright, Mark O'Neill
OBJECTIVES: This study sought to characterize direction-dependent and coupling interval-dependent changes in left atrial conduction and electrogram morphology in uniformly classified patients with paroxysmal atrial fibrillation (AF) and normal bipolar voltage mapping. BACKGROUND: Although AF classifications are based on arrhythmia duration, the clinical course, and treatment response vary between patients within these groups. Electrophysiological mechanisms responsible for this variability are incompletely described...
September 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28959111/ablation-of-ventricular-tachycardia-arising-from-the-great-cardiac-vein-a-rare-cause-of-coronary-artery-injury
#18
Allamsetty Suresh, Shih-Lin Chang, Yenn-Jiang Lin, Lei-Wei Lo, Fa-Po Chung, Shih-Ann Chen
We herein report a case of coronary artery injury during epicardial ablation of ventricular tachycardia (VT), and describe an effective method to combat such an injury. A male patient presented with recurrent palpitations which was refractory to medications, with a history of clinically documented VT during the symptomatic episodes. The ablation procedure was performed at the great cardiac vein/anterior interventricular vein (GCV/AIV) junction, in part because pace mapping showed a 12/12 match, and activation map of VT demonstrated the earliest activation site at GCV/AIV junction...
September 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28958464/mapping-under-5-and-neonatal-mortality-in-africa-2000-15-a-baseline-analysis-for-the-sustainable-development-goals
#19
Nick Golding, Roy Burstein, Joshua Longbottom, Annie J Browne, Nancy Fullman, Aaron Osgood-Zimmerman, Lucas Earl, Samir Bhatt, Ewan Cameron, Daniel C Casey, Laura Dwyer-Lindgren, Tamer H Farag, Abraham D Flaxman, Maya S Fraser, Peter W Gething, Harry S Gibson, Nicholas Graetz, L Kendall Krause, Xie Rachel Kulikoff, Stephen S Lim, Bonnie Mappin, Chloe Morozoff, Robert C Reiner, Amber Sligar, David L Smith, Haidong Wang, Daniel J Weiss, Christopher J L Murray, Catherine L Moyes, Simon I Hay
BACKGROUND: During the Millennium Development Goal (MDG) era, many countries in Africa achieved marked reductions in under-5 and neonatal mortality. Yet the pace of progress toward these goals substantially varied at the national level, demonstrating an essential need for tracking even more local trends in child mortality. With the adoption of the Sustainable Development Goals (SDGs) in 2015, which established ambitious targets for improving child survival by 2030, optimal intervention planning and targeting will require understanding of trends and rates of progress at a higher spatial resolution...
September 25, 2017: Lancet
https://www.readbyqxmd.com/read/28940739/entrainment-mapping-theoretical-considerations-and-practical-implementation
#20
Benjamin Schaeffer, William G Stevenson
Entrainment mapping enables the diagnosis and characterization of reentrant arrhythmias from analysis of the specific interaction between pacing maneuvers and tachycardia. Described 40 years ago, the implementation and interpretation of pacing maneuvers to entrain tachycardias has evolved into an indispensible tool for diagnosis and mapping reentrant cardiac arrhythmias. For complex reentry pathways entrainment mapping allows determination of the relation of pacing sites to the reentry circuit and discrimination relevant reentry parts from bystander areas...
September 22, 2017: Journal of Cardiovascular Electrophysiology
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