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https://www.readbyqxmd.com/read/29767577/the-relationship-between-inertial-measurement-unit-derived-force-signatures-and-ground-reaction-forces-during-cricket-pace-bowling
#1
Samuel J Callaghan, Robert G Lockie, Warren A Andrews, Robert F Chipchase, Sophia Nimphius
This study assessed the reliability and validity of segment measured accelerations in comparison to front foot contact (FFC) ground reaction force (GRF) during the delivery stride for cricket pace bowlers. Eleven recreational bowlers completed a 30-delivery bowling spell. Trunk- and tibia-mounted inertial measurement units (IMUs) were used to measure accelerations, converted to force, for comparisons to force plate GRF discrete measures. These measures included peak force, impulse and the continuous force-time curve in the vertical and braking (horizontal) planes...
May 16, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29759782/regional-left-ventricular-electrical-activation-and-peak-contraction-are-closely-related-in-candidates-for-cardiac-resynchronization-therapy
#2
Masih Mafi-Rad, Jetske Van't Sant, Yuri Blaauw, Pieter A Doevendans, Maarten J Cramer, Harry J Crijns, Frits W Prinzen, Mathias Meine, Kevin Vernooy
OBJECTIVES: This study determined the relationship between the timing of left ventricular (LV) electrical activation and peak contraction at potential LV pacing locations in candidates for cardiac resynchronization therapy (CRT). BACKGROUND: Targeting the LV lead to the region of latest electrical activation or the segment of latest peak contraction has both been shown to improve CRT response. Whether these regions correspond within CRT patients is uncertain. METHODS: Twenty-eight consecutive CRT candidates underwent intraprocedural coronary venous electroanatomic mapping using EnSite NavX...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759537/real-time-localization-of-ventricular-tachycardia-origin-from-the-12-lead-electrocardiogram
#3
John L Sapp, Meir Bar-Tal, Adam J Howes, Jonathan E Toma, Ahmed El-Damaty, James W Warren, Paul J MacInnis, Shijie Zhou, B Milan Horáček
OBJECTIVES: The aim of this study was to develop rapid computational methods for identifying the site of origin of ventricular activation from the 12-lead electrocardiogram. BACKGROUND: Catheter ablation of ventricular tachycardia in patients with structural heart disease frequently relies on a substrate-based approach, which may use pace mapping guided by body-surface electrocardiography to identify culprit exit sites. METHODS: Patients undergoing ablation of scar-related VT (n = 38) had 12-lead electrocardiograms recorded during pacing at left ventricular endocardial sites (n = 1,012) identified on 3-dimensional electroanatomic maps and registered to a generic left ventricular endocardial surface divided into 16 segments and tessellated into 238 triangles; electrocardiographic data were reduced for each lead to 1 variable, consisting of QRS time integral...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29754959/human-induced-pluripotent-stem-cell-derived-cardiac-cell-sheets-expressing-genetically-encoded-voltage-indicator-for-pharmacological-and-arrhythmia-studies
#4
Naim Shaheen, Assad Shiti, Irit Huber, Rami Shinnawi, Gil Arbel, Amira Gepstein, Noga Setter, Idit Goldfracht, Amit Gruber, Snizhanna V Chorna, Lior Gepstein
Fulfilling the potential of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes for studying conduction and arrhythmogenesis requires development of multicellular models and methods for long-term repeated tissue phenotyping. We generated confluent hiPSC-derived cardiac cell sheets (hiPSC-CCSs), expressing the genetically encoded voltage indicator ArcLight. ArcLight-based optical mapping allowed generation of activation and action-potential duration (APD) maps, which were validated by mapping the same hiPSC-CCSs with the voltage-sensitive dye, Di-4-ANBDQBS...
May 7, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29753180/a-work-flow-to-build-and-validate-patient-specific-left-atrium-electrophysiology-models-from-catheter-measurements
#5
Cesare Corrado, Steven Williams, Rashed Karim, Gernot Plank, Mark O'Neill, Steven Niederer
Biophysical models of the atrium provide a physically constrained framework for describing the current state of an atrium and allow predictions of how that atrium will respond to therapy. We propose a work flow to simulate patient specific electrophysiological heterogeneity from clinical data and validate the resulting biophysical models. In 7 patients, we recorded the atrial anatomy with an electroanatomical mapping system (St Jude Velocity); we then applied an S1-S2 electrical stimulation protocol from the coronary sinus (CS) and the high right atrium (HRA) whilst recording the activation patterns using a PentaRay catheter with 10 bipolar electrodes at 12 ± 2 sites across the atrium...
April 27, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29744936/distribution-and-protection-of-climatic-refugia-in-north-america
#6
Julia L Michalak, Joshua J Lawler, David R Roberts, Carlos Carroll
As evidenced by past climatic refugia, locations projected to harbor remnants of present day climates may serve as critical refugia for current biodiversity in the face of modern climate change. Here, we map potential future climatic refugia across North America, defined as locations with increasingly rare climatic conditions. We identified these locations by tracking projected changes in the size and distribution of climate analogs over time. We used biologically-derived thresholds to define analogs and tested the impacts of dispersal limitation using four distances to limit analog searches...
May 10, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29742384/reproductive-biology-of-captive-female-southern-hairy-nosed-wombats-lasiorhinus-latifrons-part-2-oestrous-behaviour
#7
Alyce M Swinbourne, Clive J C Phillips, Tina Janssen, Allan Lisle, Tamara Keeley, Stephen D Johnston
The poor captive breeding success of southern hairy-nosed wombats (SHNWs; Lasiorhinus latifrons) has been attributed to the difficulty in accurately characterising oestrous behaviour and their relationship to circulating reproductive hormones. Over two wombat breeding seasons, the use of infrared cameras for 24-h remote behavioural monitoring and the analysis of urine samples collected from seven captive females, were investigated to determine the relationship between behaviour and changes in urinary progesterone metabolites (P4M)...
May 10, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29730991/feasibility-of-cardiovascular-magnetic-resonance-to-detect-oxygenation-deficits-in-patients-with-multi-vessel-coronary-artery-disease-triggered-by-breathing-maneuvers
#8
Kady Fischer, Kyohei Yamaji, Silvia Luescher, Yasushi Ueki, Bernd Jung, Hendrik von Tengg-Kobligk, Stephan Windecker, Matthias G Friedrich, Balthasar Eberle, Dominik P Guensch
BACKGROUND: Hyperventilation with a subsequent breath-hold has been successfully used as a non-pharmacological vasoactive stimulus to induce changes in myocardial oxygenation. The purpose of this pilot study was to assess if this maneuver is feasible in patients with multi-vessel coronary artery disease (CAD), and if it is effective at detecting coronary artery stenosis > 50% determined by quantitative coronary angiography (QCA). METHODS: Twenty-six patients with coronary artery stenosis (QCA > 50% diameter stenosis) underwent a contrast-free cardiovascular magnetic resonance (CMR) exam in the time interval between their primary coronary angiography and a subsequent percutaneous coronary intervention (PCI, n = 24) or coronary artery bypass (CABG, n = 2) revascularization procedure...
May 7, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29720992/tools-for-genetic-studies-in-experimental-populations-of-polyploids
#9
REVIEW
Peter M Bourke, Roeland E Voorrips, Richard G F Visser, Chris Maliepaard
Polyploid organisms carry more than two copies of each chromosome, a condition rarely tolerated in animals but which occurs relatively frequently in the plant kingdom. One of the principal challenges faced by polyploid organisms is to evolve stable meiotic mechanisms to faithfully transmit genetic information to the next generation upon which the study of inheritance is based. In this review we look at the tools available to the research community to better understand polyploid inheritance, many of which have only recently been developed...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29704856/fast-mapping-word-meanings-across-trials-young-children-forget-all-but-their-first-guess
#10
Athulya Aravind, Jill de Villiers, Amy Pace, Hannah Valentine, Roberta Golinkoff, Kathy Hirsch-Pasek, Aquiles Iglesias, Mary Sweig Wilson
Do children learn a new word by tracking co-occurrences between words and referents across multiple instances ("cross-situational learning" models), or is word-learning a "one-track" process, where learners maintain a single hypothesis about the possible referent, which may be verified or falsified in future occurrences ("propose-but-verify" models)? Using a novel word-learning task, we ask which learning procedure is utilized by preschool-aged children. We report on findings from three studies comparing the word-learning strategies across different populations of child learners: monolingual English learners, Spanish - English dual language learners, and learners at risk for language-delay...
April 25, 2018: Cognition
https://www.readbyqxmd.com/read/29702740/localization-of-ventricular-activation-origin-using-patient-specific-geometry-preliminary-results
#11
Shijie Zhou, John L Sapp, Amir AbdelWahab, Petr Šťovíček, B Milan Horáček
BACKGROUND AND OBJECTIVES: Catheter ablation of ventricular tachycardia (VT) may include induction of VT and localization of VT-exit site. Our aim was to assess localization performance of a novel statistical pace-mapping method and compare it with performance of an electrocardiographic inverse solution. METHODS: Seven patients undergoing ablation of VT (4 with epicardial, 3 with endocardial exit) aided by electroanatomic mapping underwent intraprocedural 120-lead body-surface potential mapping (BSPM)...
April 27, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29701778/voltage-and-pace-capture-mapping-of-linear-ablation-lesions-overestimates-chronic-ablation-gap-size
#12
Louisa O'Neill, James Harrison, Henry Chubb, John Whitaker, Rahul K Mukherjee, Lars Ølgaard Bloch, Niels Peter Andersen, Høgni Dam, Henrik K Jensen, Steven Niederer, Matthew Wright, Mark O'Neill, Steven E Williams
Aims: Conducting gaps in lesion sets are a major reason for failure of ablation procedures. Voltage mapping and pace-capture have been proposed for intra-procedural identification of gaps. We aimed to compare gap size measured acutely and chronically post-ablation to macroscopic gap size in a porcine model. Methods and results: Intercaval linear ablation was performed in eight Göttingen minipigs with a deliberate gap of ∼5 mm left in the ablation line. Gap size was measured by interpolating ablation contact force values between ablation tags and thresholding at a low force cut-off of 5 g...
April 26, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29700862/the-quantitative-assessment-of-epicardial-fat-distribution-on-human-hearts-implications-for-epicardial-electrophysiology
#13
Alexander R Mattson, Mario J Soto, Paul A Iaizzo
INTRODUCTION: Epicardial electrophysiological procedures rely on dependable interfacing with the myocardial tissue. For example, epicardial pacing systems must generate sustainable chronic pacing capture, while epicardial ablations must effectively deliver energy to the target hyper-excitable myocytes. The human heart has a significant adipose layer which may impede epicardial procedures. The objective of this study was to quantitatively assess the relative location of epicardial adipose on the human heart, in order to define locations where epicardial therapies might be performed successfully...
April 26, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29700057/how-accurate-is-inverse-electrocardiographic-mapping-a-systematic-in-vivo-evaluation
#14
Laura R Bear, Ian J LeGrice, Gregory B Sands, Nigel A Lever, Denis S Loiselle, David J Paterson, Leo K Cheng, Bruce H Smaill
BACKGROUND: Inverse electrocardiographic mapping reconstructs cardiac electrical activity from recorded body surface potentials. This noninvasive technique has been used to identify potential ablation targets. Despite this, there has been little systematic evaluation of its reliability. METHODS: Torso and ventricular epicardial potentials were recorded simultaneously in anesthetized, closed-chest pigs (n=5), during sinus rhythm, epicardial, and endocardial ventricular pacing (70 records in total)...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29688109/power-output-and-pacing-during-international-cross-country-mountain-bike-cycling
#15
Cyril Granier, Chris R Abbiss, Anaël Aubry, Yvon Vauchez, Sylvain Dorel, Christophe Hausswirth, Yann Le Meur
PURPOSE: To characterize the physiological profiles of elite cross-country mountain bike (XCO-MTB) cyclists, and to examine their pacing and power output (PO) distribution during international races. METHODS: Over two competitive seasons, eight elite male XCO-MTB cyclists (VO2 max: 79.9 ± 5.2 ml.min-1 .kg-1 , MAP: 411 ± 18 W and 6.3 ± 0.4 W.kg-1 ) regularly undertook incremental tests to assess their PO and heart rate (HR) at first and second ventilatory thresholds (VT1 and VT2) and at VO2max ...
April 24, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29686410/quantitative-optical-mapping-of-two-dimensional-materials
#16
Bjarke S Jessen, Patrick R Whelan, David M A Mackenzie, Birong Luo, Joachim D Thomsen, Lene Gammelgaard, Timothy J Booth, Peter Bøggild
The pace of two-dimensional materials (2DM) research has been greatly accelerated by the ability to identify exfoliated thicknesses down to a monolayer from their optical contrast. Since this process requires time-consuming and error-prone manual assignment to avoid false-positives from image features with similar contrast, efforts towards fast and reliable automated assignments schemes is essential. We show that by modelling the expected 2DM contrast in digitally captured images, we can automatically identify candidate regions of 2DM...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669703/physical-activity-sedentary-behavior-and-diet-related-ehealth-and-mhealth-research-bibliometric-analysis
#17
REVIEW
Andre Matthias Müller, Carol A Maher, Corneel Vandelanotte, Melanie Hingle, Anouk Middelweerd, Michael L Lopez, Ann DeSmet, Camille E Short, Nicole Nathan, Melinda J Hutchesson, Louise Poppe, Catherine B Woods, Susan L Williams, Petra A Wark
BACKGROUND: Electronic health (eHealth) and mobile health (mHealth) approaches to address low physical activity levels, sedentary behavior, and unhealthy diets have received significant research attention. However, attempts to systematically map the entirety of the research field are lacking. This gap can be filled with a bibliometric study, where publication-specific data such as citations, journals, authors, and keywords are used to provide a systematic overview of a specific field...
April 18, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29669504/atrial-fibrillation-in-autoimmune-rheumatic-diseases-from-the-pathogenesis-to-the-treatment
#18
Giuseppe Ciconte, Manuel Conti, Martina Evangelista, Carlo Pappone
BACKGROUND: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in the general population and is associated with an increased number of adverse outcomes. The onset and maintenance of this arrhythmia requires a trigger event and the presence of a predisposing substrate. Atrial fibrosis, a major characteristic of AF-related structural remodeling, represents a process closely related to inflammation as demonstrated by emerging evidence. Aim of this article is to review the evidence linking AF to systemic autoimmune diseases...
April 17, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29668674/the-influences-of-the-m2r-girk4-rgs6-dependent-parasympathetic-pathway-on-electrophysiological-properties-of-the-mouse-heart
#19
Kanchan Kulkarni, Xueyi Xie, Ezequiel Marron Fernandez de Velasco, Allison Anderson, Kirill A Martemyanov, Kevin Wickman, Elena G Tolkacheva
A large body of work has established the prominent roles of the atrial M2R-IKACh signaling pathway, and the negative regulatory protein RGS6, in modulating critical aspects of parasympathetic influence on cardiac function, including pace-making, heart rate (HR) variability (HRV), and atrial arrhythmogenesis. Despite increasing evidence of its innervation of the ventricles, and the expression of M2R, IKACh channel subunits, and RGS6 in ventricle, the effects of parasympathetic modulation on ventricular electrophysiology are less clear...
2018: PloS One
https://www.readbyqxmd.com/read/29629868/computed-tomography-identified-factors-that-preclude-living-kidney-donation
#20
Katerina Mastrocostas, Christina M Chingkoe, Kenneth T Pace, Joseph J Barfett, Anish Kirpalani, Gevork N Mnatzakanian, Paraskevi A Vlachou, Errol Colak
INTRODUCTION: The purpose of this study was to determine the variety and prevalence of renal and non-renal abnormalities detected on multi-detector computed tomography (MDCT) that precluded patients from donating a kidney. METHODS: Institutional review board approval was obtained and the requirement for informed consent was waived. A retrospective, single-centre review of 701 patients (444 female, 257 male; age range 18-86 years; mean age 43.2±11.9 years) that underwent renal donor protocol MDCT was conducted...
April 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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