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https://www.readbyqxmd.com/read/28730712/slow-conduction-through-an-arc-of-block-a-basis-for-arrhythmia-formation-post-myocardial-infarction
#1
Eugene Patterson, Benjamin J Scherlag, Edward J Berbari, Ralph Lazzara
INTRODUCTION: The electrophysiologic basis for characteristic rate-dependent, constant-late-coupled (390+54 msec) premature ventricular beats (PVBs) present 4-5 days following coronary artery occlusion were examined in 108 anesthetized dogs. METHODS AND RESULTS: Fractionated/double potentials were observed in injured zone bipolar and composite electrograms at prolonged sinus cycle lengths (1296 ± 396 msec). At shorter cycle lengths, conduction of the delayed potential decremented, separating from the initial electrogram by a progressively prolonged isoelectric interval...
July 21, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28730651/a-comparison-of-the-electrophysiologic-and-electroanatomic-characteristics-between-the-right-and-left-atrium-in-persistent-atrial-fibrillation-is-the-right-atrium-a-window-into-the-left
#2
Sandeep Prabhu, Aleksandr Voskoboinik, Alex Ja McLellan, Kah Y Peck, Bupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Geoffrey Lee, Justin Mariani, Liang-Han Ling, Andrew J Taylor, Jonathan M Kalman, Peter M Kistler
INTRODUCTION: The right atrium (RA) is readily accessible; however, it is unclear whether changes in the RA are representative of the LA. We performed detailed bi-atrial electroanatomic mapping to determine the electrophysiological relationship between the atria. METHODS AND RESULTS: Consecutive patients with persistent AF underwent bi-atrial electroanatomical mapping with a contact force catheter acquiring points with a CF > 10 g prior to ablation. Points were analyzed for tissue voltage, complex electrograms, low voltage (< 0...
July 21, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28714074/altered-metabolomic-genomic-signature-a-potential-noninvasive-biomarker-of-epilepsy
#3
Helen C Wu, Fabien Dachet, Farhad Ghoddoussi, Shruti Bagla, Darren Fuerst, Jeffrey A Stanley, Matthew P Galloway, Jeffrey A Loeb
OBJECTIVE: This study aimed to identify noninvasive biomarkers of human epilepsy that can reliably detect and localize epileptic brain regions. Having noninvasive biomarkers would greatly enhance patient diagnosis, patient monitoring, and novel therapy development. At the present time, only surgically invasive, direct brain recordings are capable of detecting these regions with precision, which severely limits the pace and scope of both clinical management and research progress in epilepsy...
July 17, 2017: Epilepsia
https://www.readbyqxmd.com/read/28695661/relationships-between-gastric-slow-wave-frequency-velocity-and-extracellular-amplitude-studied-by-a-joint-experimental-theoretical-approach
#4
T H-H Wang, P Du, T R Angeli, N Paskaranandavadivel, J C Erickson, T L Abell, L K Cheng, G O'Grady
BACKGROUND: Gastric slow wave dysrhythmias are accompanied by deviations in frequency, velocity, and extracellular amplitude, but the inherent association between these parameters in normal activity still requires clarification. This study quantified these associations using a joint experimental-theoretical approach. METHODS: Gastric pacing was conducted in pigs with simultaneous high-resolution slow wave mapping (32-256 electrodes; 4-7.6 mm spacing). Relationships between period, velocity, and amplitude were quantified and correlated for each wavefront...
July 11, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28695377/ventricular-dyssynchrony-assessment-using-ultra-high-frequency-ecg-technique
#5
Pavel Jurak, Josef Halamek, Jaroslav Meluzin, Filip Plesinger, Tereza Postranecka, Jolana Lipoldova, Miroslav Novak, Vlastimil Vondra, Ivo Viscor, Ladislav Soukup, Petr Klimes, Petr Vesely, Josef Sumbera, Karel Zeman, Roshini S Asirvatham, Jason Tri, Samuel J Asirvatham, Pavel Leinveber
PURPOSE: The aim of this proof-of-concept study is to introduce new high-dynamic ECG technique with potential to detect temporal-spatial distribution of ventricular electrical depolarization and to assess the level of ventricular dyssynchrony. METHODS: 5-kHz 12-lead ECG data was collected. The amplitude envelopes of the QRS were computed in an ultra-high frequency band of 500-1000 Hz and were averaged (UHFQRS). UHFQRS V lead maps were compiled, and numerical descriptor identifying ventricular dyssynchrony (UHFDYS) was detected...
July 10, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28680604/atrial-flutter-in-a-patient-with-atrial-septal-defect-and-anomalous-venous-drainage-unusual-approach-for-ablation
#6
Ivo Roca-Luque, Nuria Rivas, Laura Dos, Jaume Francisco, Jordi Pérez-Rodon, Antònia Pijuan, David Garcia-Dorado, Àngel Moya
Atrial flutter ablation in CHD (Congenital Heart Disease) patients is a challenging procedure because of the possibility of multiple circuits. Electroanatomical mapping and pacing maneuvers are crucial to determine critical isthmus. Moreover, vascular abnormalities and residual cardiac defects need to be known before the ablation to decide the better strategy for ablation.
July 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28667054/analysis-of-decreases-in-systemic-arterial-pressure-and-heart-rate-in-response-to-the-hydrogen-sulfide-donor-sodium-sulfide
#7
Kevin W Swan, Bryant Minkyu Song, Allen L Chen, Travis J Chen, Ryan A Chan, Bradley T Guidry, Prasad V G Katakam, Edmund K Kerut, Thomas D Giles, Philip Kadowitz
The actions of hydrogen sulfide (H2S) on the heart and vasculature have been extensively reported. However, the mechanisms underlying the effects of H2S are unclear in the anesthetized rat. The objective of the current study is to investigate the effect of H2S on the electrocardiogram and examine the relationship between H2S-induced changes in heart rate (HR), mean arterial pressure (MAP), and respiratory function. Intravenous (iv) administration of the H2S donor sodium sulfide (Na2S) in the anesthetized Sprague-Dawley (SD) rat decreased MAP and HR and produced changes in respiratory function...
June 30, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28661206/protective-regulation-of-the-ace2-ace-gene-expression-by-estrogen-in-human-atrial-tissue-from-elderly-men
#8
A Bukowska, L Spiller, C Wolke, U Lendeckel, S Weinert, J Hoffmann, P Bornfleth, I Kutschka, A Gardemann, B Isermann, A Goette
Data from animal experiments and clinical investigations suggest that components of the renin-angiotensin system are markedly affected by sex hormones. However, whether estrogen affects human atrial myocardium has not been investigated yet. In this study, we determined the effects of estrogen on key components of atrial renin-angiotensin system: angiotensin-converting enzyme, responsible for generation of angiotensin II and angiotensin-converting enzyme 2, counteracting majority of AngII effects, and different renin-angiotensin system receptors, AT1R, AT2R, and MAS...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28649507/permanent-his-bundle-pacing-at-the-time-of-atrioventricular-node-ablation-a-3-dimensional-mapping-approach
#9
Sukit Ringwala, Bradley P Knight, Nishant Verma
No abstract text is available yet for this article.
June 2017: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28641861/permanent-his-bundle-pacing-in-intra-hisian-conduction-block-mechanistic-insights
#10
Bengt Herweg, Paul Z Gerczuk, Aamir Sofi, Pugazhendhi Vijayaraman, S Serge Barold
We are reporting a patient with discrete intra-His conduction block and describe a refined technique of permanent His bundle pacing assuring reliable ventricular capture. Meticulous mapping of the site of block with lead placement distal to the site of block and non-selective His bundle pacing with local myocardial capture as an additional safety back up appears to be the technique of choice.
June 9, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28639747/the-effect-of-activation-rate-on-left-atrial-bipolar-voltage-in-patients-with-paroxysmal-atrial-fibrillation
#11
Steven E Williams, Nick Linton, Louisa O'Neill, James Harrison, John Whitaker, Rahul Mukherjee, Christopher A Rinaldi, Jaswinder Gill, Steven Niederer, Matthew Wright, Mark O'Neill
INTRODUCTION: Bipolar voltage is used during electroanatomic mapping to define abnormal myocardium, but the effect of activation rate on bipolar voltage is not known. We hypothesized that bipolar voltage may change in response to activation rate. By examining corresponding unipole signals we sought to determine the mechanisms of such changes. METHODS AND RESULTS: LA extrastimulus mapping was performed during CS pacing in 10 patients undergoing 1(st) time paroxysmal atrial fibrillation ablation...
June 22, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28630174/experimental-pathologic-and-clinical-findings-of-radiofrequency-catheter-ablation-of-para-hisian-region-from-the-right-ventricle-in-dogs-and-humans
#12
Yumei Xue, Xianzhang Zhan, Shulin Wu, Hongyue Wang, Yang Liu, Zili Liao, Hai Deng, Xuejing Duan, Shaoying Zeng, Dongpo Liang, Arif Elvan, Xianhong Fang, Hongtao Liao, Anand R Ramdat Misier, Jaap Jan J Smit, Andreas Metzner, Christian-Hendrik Heeger, Fangzhou Liu, Feng Wang, Zhiwei Zhang, Karl-Heinz Kuck, Siew Yen Ho, Feifan Ouyang
BACKGROUND: Ablation of para-Hisian accessory pathway (AP) poses high risks of atrioventricular block. We developed a pacing technique to differentiate the near-field (NF) from far-field His activations to avoid the complication. METHODS AND RESULTS: Three-dimensional mapping of the right ventricle was performed in 15 mongrel dogs and 23 patients with para-Hisian AP. Using different pacing outputs, the NF- and far-field His activation was identified on the ventricular aspect...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28626939/technical-note-a-3-d-rendering-algorithm-for-electromechanical-wave-imaging-of-a-beating-heart
#13
Pierre Nauleau, Lea Melki, Elaine Wan, Elisa Konofagou
PURPOSE: Arrhythmias can be treated by ablating the heart tissue in the regions of abnormal contraction. The current clinical standard provides electroanatomic 3- D maps to visualize the elec-trical activation and locate the arrhythmogenic sources. However, the procedure is time-consuming and invasive. Electromechanical Wave Imaging is an ultrasound- based non-invasive technique that can provide 2-D maps of the electromechanical activation of the heart. In order to fully visualize the complex 3-D pattern of activation, several 2-D views are acquired and processed separately They are then manually registered with a 3-D rendering software to generate a pseudo-3-D map However, this last step is operator-dependent and time-consuming...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28625927/entrainment-and-high-density-three-dimensional-mapping-in-right-atrial-macroreentry-provide-critical-complementary-information-entrainment-may-unmask-visual-reentry-as-passive
#14
Bhupesh Pathik, Geoffrey Lee, Chrishan Nalliah, Stephen Joseph, Joseph B Morton, Paul B Sparks, Prashanthan Sanders, Peter M Kistler, Jonathan M Kalman
BACKGROUND: With the recent advent of high-density (HD) 3-dimensional (3D) mapping, the utility of entrainment is uncertain. However, the limitations of visual representation and interpretation of these high-resolution 3D maps are unclear. OBJECTIVE: The purpose of this study was to determine the strengths and limitations of both HD 3D mapping and entrainment mapping during mapping of right atrial macroreentry. METHODS: Fifteen patients were studied...
June 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28617864/pitch-contour-impairment-in-congenital-amusia-new-insights-from-the-self-paced-audio-visual-contour-task-sact
#15
Xuejing Lu, Yanan Sun, Hao Tam Ho, William Forde Thompson
Individuals with congenital amusia usually exhibit impairments in melodic contour processing when asked to compare pairs of melodies that may or may not be identical to one another. However, it is unclear whether the impairment observed in contour processing is caused by an impairment of pitch discrimination, or is a consequence of poor pitch memory. To help resolve this ambiguity, we designed a novel Self-paced Audio-visual Contour Task (SACT) that evaluates sensitivity to contour while placing minimal burden on memory...
2017: PloS One
https://www.readbyqxmd.com/read/28601532/genetics-of-atrial-fibrillation-state-of-the-art-in-2017
#16
REVIEW
Diane Fatkin, Celine F Santiago, Inken G Huttner, Steven A Lubitz, Patrick T Ellinor
Genetic variation is an important determinant of atrial fibrillation (AF) susceptibility. Numerous rare variants in protein-coding sequences of genes have been associated with AF in families and in early-onset cases, and chromosomal loci harbouring common risk variants have been mapped in AF cohorts. Many of these loci are in non-coding regions of the human genome and are thought to contain regulatory sequences that modulate gene expression. Disease genes implicated to date have predominantly encoded cardiac ion channels, with predicted mutation effects on the atrial action potential duration...
May 11, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28590351/a-novel-approach-to-optimal-placement-of-new-trauma-centers-within-an-existing-trauma-system-using-geospatial-mapping
#17
Michael A Horst, Frederick B Rogers, Brian W Gross, Alan D Cook, Turner M Osler, Eric H Bradburn
BACKGROUND: Trauma system expansion is a complex process often governed by financial and health care system imperatives. We sought to propose a new, informed approach to trauma system expansion through the use of geospatial mapping. We hypothesized that geospatial mapping set to specific parameters could effectively identify optimal placement of new trauma centers (TC) within an existing trauma system. METHODS: We used Pennsylvania Trauma Systems Foundation (PTSF) registry data of adult (age ≥ 15) trauma for calendar years 2003-2015 (n=408,432), hospital demographics, road networks, and US Census data files...
June 6, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28579601/efficacy-of-intensive-radiofrequency-energy-delivery-to-the-localized-dense-scar-area-in-post-infarction-ventricular-tachycardia-ablation%C3%A3-a-comparative-study-with-standard-strategy-targeting-the-infarcted-border-zone
#18
Kenji Kuroki, Akihiko Nogami, Kentaro Yoshida, Masahiko Goya, Masato Fukunaga, Kazuaki Kaitani, Naoaki Onishi, Takanao Mine, Takashi Koyama, Masayuki Igawa, Takeshi Machino, Hiro Yamasaki, Dongzhu Xu, Miyako Igarashi, Nobuyuki Murakoshi, Yukio Sekiguchi, Kazutaka Aonuma
BACKGROUND: Several reports have demonstrated the importance of severely low voltage areas as arrhythmogenic substrates of ventricular tachycardia (VT). However, a comparative study of dense scar-targeted and infarcted border zone-targeted strategies has not been reported.Methods and Results:We divided 109 consecutive patients with VT post-infarction from 6 centers into 2 groups according to the ablation strategy used: dense scar-targeted ablation (DS ablation, 48%) or border zone-targeted ablation (BZ ablation, 52%)...
June 3, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28570440/successful-reinnervation-of-the-diaphragm-after-intercostal-to-phrenic-nerve-neurotization-in-patients-with-high-spinal-cord-injury
#19
Kulvir S Nandra, Martin Harari, Thea P Price, Patrick J Greaney, Michael S Weinstein
OBJECTIVE: Our objective in this study was to extend diaphragmatic pacing therapy to include paraplegic patients with high cervical spinal cord injuries between C3 and C5. INTRODUCTION: Diaphragmatic pacing has been used in patients experiencing ventilator-dependent respiratory failure due to spinal cord injury as a means to reduce or eliminate the need for mechanical ventilation. However, this technique relies on intact phrenic nerve function. Recently, phrenic nerve reconstruction with intercostal nerve grafting has expanded the indications for diaphragmatic pacing...
August 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28569191/the-strategic-framework-of-tuberculosis-control-and-prevention-in-the-elderly-a-scoping-review-towards-end-tb-targets
#20
REVIEW
Jun Li, Pui-Hong Chung, Cyrus L K Leung, Nobuyuki Nishikiori, Emily Y Y Chan, Eng-Kiong Yeoh
With the rapid pace of population ageing, tuberculosis (TB) in the elderly increasingly becomes a public health challenge. Despite the increasing burden and high risks for TB in the elderly, targeted strategy has not been well understood and evaluated. We undertook a scoping review to identify current TB strategies, research and policy gaps in the elderly and summarized the results within a strategic framework towards End TB targets. Databases of Embase, MEDLINE, Global health and EBM reviews were searched for original studies, review articles, and policy papers published in English between January 1990 and December 2015...
June 1, 2017: Infectious Diseases of Poverty
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