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Anesthesia and cognitive function

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https://www.readbyqxmd.com/read/29665808/critical-role-of-nlrp3-caspase-1-pathway-in-age-dependent-isoflurane-induced-microglial-inflammatory-response-and-cognitive-impairment
#1
Zhi Wang, Shiyu Meng, Lin Cao, Ying Chen, Zhiyi Zuo, Shuling Peng
BACKGROUND: Elderly patients are more likely to suffer from postoperative cognitive dysfunction (POCD) after surgery and anesthesia. Except for declined organ function, the particular pathogenesis of POCD in elderly patients remains unknown. This study is carried out to determine the critical role of the NOD-like receptor protein 3 (NLRP3)-caspase-1 pathway in isoflurane-induced cognitive impairment. METHODS: Young (6-8 months old) and aged (14 months old) healthy male C57BL/6 mice were exposed to 1...
April 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29656804/tools-to-screen-and-measure-cognitive-impairment-after-surgery-and-anesthesia
#2
Sérgio Vide, Pedro L Gambús
Cognition is essential to all aspects of our everyday life. Although we take our cognitive function for granted, the perioperative period is prone to several aggressions that might impair it. Postoperative cognitive dysfunction, has been the aim of many studies recently, and was shown to be very common with an incidence that can reach 40%, yielding not only impairment in cognition, but also longer hospital stays, higher costs and greater mortality. While several studies have revealed some of the mechanisms contributing to postoperative cognitive dysfunction, the search for the perfect instrument to screen and measure cognitive (dys)function has proven more elusive...
April 12, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29643802/the-beneficial-effects-of-cognitive-training-with-simple-calculation-and-reading-aloud-scra-in-the-elderly-postoperative-population-a-pilot-randomized-controlled-trial
#3
Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima
Background: There has been little research conducted regarding cognitive treatments for the elderly postsurgical population. Patients aged ≥60 years have an increased risk of postoperative cognitive decline, a condition in which cognitive functions are negatively affected. This cognitive decline can lead to a decline in quality of life. In order to maintain a high quality of life, the elderly postsurgical population may benefit from treatment to maintain and/or improve their cognitive functions. This pilot study investigates the effect of simple calculation and reading aloud (SCRA) cognitive training in elderly Japanese postsurgical patients...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29628565/postoperative-cognitive-dysfunction-in-indian-patients-undergoing-total-knee-replacement-under-spinal-anesthesia
#4
Praful Kilaru, A Ramachandra Reddy, Maryada Venketeshwar Reddy, Brijesh Kidiyoor, Vinay Mathew Joseph, Annapareddy Venkata Gurava Reddy
Introduction: Total knee replacement is a common surgical procedure in the elderly. The number of surgeries has increased owing to the increasing life expectancy of the population and better functional outcomes postsurgery. Postoperative cognitive dysfunction (POCD) is an identified entity postsurgery in elderly but most of the studies have been on patients undergoing cardiac and other nonorthopaedic surgeries. The studies have shown variable incidence due to selection bias. We studied the incidence and probable predictive factors of POCD in elderly Indian population undergoing total knee replacement under spinal anesthesia...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29599834/improvement-of-postoperative-cognitive-dysfunction-and-attention-network-function-of-patients-with-ischemic-cerebrovascular-disease-via-dexmedetomidine
#5
Jingchao Zhang, Guoliang Wang, Fangxiang Zhang, Qian Zhao
The protective effect of dexmedetomidine on cognitive dysfunction and decreased attention network function of patients with ischemic cerebrovascular disease after stenting was investigated. Fifty-eight patients with ischemic cerebrovascular disease undergoing stenting in Guizhou Provincial People's Hospital were selected and randomly divided into control group (n=29) and dexmedetomidine group (n=29). The dexmedetomidine group was treated with dexmedetomidine before induced anesthesia, while the control group was given the same dose of normal saline; and the normal volunteers of the same age were selected as the normal group (n=29)...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29578002/inhibition-of-microrna-34a-protects-against-propofol-anesthesia-induced-neurotoxicity-and-cognitive-dysfunction-via-the-mapk-erk-signaling-pathway
#6
Guang Feng Li, Su Jing Zhuang, Guang Cai Li
AIM: To investigate the protective effect of microRNA-34a (miR-34a) on propofol-induced neurotoxicity and cognitive dysfunction. METHODS: After SH-SY5Y cells were treated with propofol to induce neurotoxicity, microRNA-34a mimics and inhibitors were transfected into the cells. The expression of apoptosis-related genes and the proteins were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot. Sprague-Dawley (SD) rats received intraperitoneal injections of propofol, and were treated with microRNA-34a mimics and lentivirus-mediated microRNA-34a inhibitors...
March 22, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29563982/propofol-and-sevoflurane-combined-with-remifentanil-on-the-pain-index-inflammatory-factors-and-postoperative-cognitive-function-of-spine-fracture-patients
#7
Yu Zhao, Hongqi Zhang
The effects of propofol vs. sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function in spine fracture patients were studied and analyzed. A total of 62 patients with vertebral fracture were randomly divided into the propofol group (P group, n=41) and the sevoflurane group (S group, n=41). P group used induction anesthesia with propofol, and maintained anesthesia via intravenous injection of remifentanil. While patients in S group received induction anesthesia with sevoflurane, and also remifentanil as the maintained anesthesia...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29551921/effect-of-dexmedetomidine-induced-anesthesia-on-the-postoperative-cognitive-function-of-elder-patients-after-laparoscopic-ovarian-cystectomy
#8
Hui-Ying Xu, Guang-Hua Fu, Gui-Sheng Wu
Objective: To investigate the effect of dexmedetomidine at maintenance dose on the postoperative function of elder patients after general anesthesia for laparoscopic ovarian cystectomy. Methods: We enrolled a total of 96 elder patients who were admitted to this hospital for laparoscopic ovarian cystectomy under general anesthesia between March 2015 and March 2017, and divided them into two groups, Group A (n = 48) and B (n = 48). Patients in both groups received the same methods for anesthesia induction and maintenance drugs...
December 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29550773/ability-of-postoperative-delirium-to-predict-intermediate-term-postoperative-cognitive-function-in-patients-undergoing-elective-surgery-at-an-academic-medical-centre-protocol-for-a-prospective-cohort-study
#9
Amrita Aranake-Chrisinger, Jenny Zhao Cheng, Maxwell R Muench, Rose Tang, Angela Mickle, Hannah Maybrier, Nan Lin, Troy Wildes, Eric Lenze, Michael Simon Avidan
INTRODUCTION: Postoperative delirium (POD) is a common complication in elderly patients, characterised by a fluctuating course of altered consciousness, disordered thinking and inattention. Preliminary research has linked POD with persistent cognitive impairment and decreased quality of life. However, these findings maybe confounded by patient comorbidities, postoperative complications and frailty. Our objective is to determine whether POD is an independent risk factor for persistent impairments in attention and executive function after elective surgery...
March 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29502203/amantadine-attenuates-sepsis-induced-cognitive-dysfunction-possibly-not-through-inhibiting-toll-like-receptor-2
#10
Wei Xing, Pinjie Huang, Yang Lu, Weian Zeng, Zhiyi Zuo
Amantadine has been shown to reduce anesthesia and surgery-induced neuroinflammation and cognitive dysfunction. It is known that sepsis can impair brain function. We determined whether amantadine-attenuated sepsis-induced neuroinflammation and dysfunction of learning and memory and whether toll-like receptors (TLRs) play a role in the effects. Six- to eight-week-old mice were subjected to cecal ligation and puncture (CLP). Amantadine at 30 mg/kg/day was injected intraperitoneally for 3 days. CU-CPT22, a TLR1/TLR2 inhibitor, at 3 mg/kg/day was injected intraperitoneally for 2 days...
May 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29502058/-effect-of-propofol-and-operative-trauma-on-neurodevelopment-and-cognitive-function-of-developing-brain-in-rats
#11
Yang Li, Wei-Guang Li, Ze-Guo Feng, Cheng-Gang Zhang, Lian-Jun Huang, Xiao-Rui Yang, Ying-Qun Yu
OBJECTIVE: To investigate the effect of propofol and operative trauma on the neurodevelopment and cognitive function of the developing brain and its mechanism. METHODS: A total of 104 postnatal day 13 Sprague-Dawley rats were randomly divided into 4 groups: control group (treated by 7.5 mL/kg saline and sham surgery), propofol group (treated by 75 mg/kg propofol), surgery group (with abdominal surgery under local anesthesia) and propofol+surgery group (with abdominal surgery under local anesthesia plus 75 mg/kg propofol anesthesia)...
February 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29487299/differential-modulation-of-the-auditory-steady-state-response-and-inhibitory-gating-by-chloral-hydrate-anesthesia
#12
Yuchen Wang, Lanlan Ma, Xuejiao Wang, Ling Qin
Auditory steady state response (ASSR) and inhibitory gating (IG) are electrophysiological examinations commonly used to evaluate the sensory and cognitive functions of the brain. In some clinic examinations and animal experiments, general anesthesia is necessary to conduct electrophysiological recordings. However, the effects of anesthesia on ASSR and IG remain unclear. For this reason, we recorded local field potentials though electrodes implanted in different brain areas of rats: the auditory cortex (AC), hippocampus (HC), amygdala (AMY), and prefrontal cortex (PFC), and compared the characteristics of ASSR and IG under anesthetized and conscious conditions...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459369/the-nucleus-reuniens-controls-long-range-hippocampo-prefrontal-gamma-synchronization-during-slow-oscillations
#13
Maëva Ferraris, Antoine Ghestem, Ana F Vicente, Lauriane Nallet-Khosrofian, Christophe Bernard, Pascale P Quilichini
Gamma oscillations are involved in long-range coupling of distant regions which support various cognitive operations. Here we show in adult male rats that synchronized bursts of gamma oscillations bind the hippocampus (HPC) and prefrontal cortex (mPFC) during slow oscillations and slow wave sleep, a brain state that is central for consolidation of memory traces. These gamma bursts entrained the firing of the local HPC and mPFC neuronal populations. Neurons of the nucleus reuniens (NR), which is a structural and functional hub between HPC and mPFC, demonstrated a specific increase in their firing prior to gamma burst onset, suggesting their involvement in HPC-mPFC binding...
February 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29439328/impact-of-total-knee-arthroplasty-with-general-anesthesia-on-brain-networks-cognitive-efficiency-and-ventricular-volume-predict-functional-connectivity-decline-in-older-adults
#14
Haiqing Huang, Jared Tanner, Hari Parvataneni, Mark Rice, Ann Horgas, Mingzhou Ding, Catherine Price
 Using resting state functional magnetic resonance imaging (RS-fMRI), we explored: 1) pre- to post-operative changes in functional connectivity in default mode, salience, and central executive networks after total knee arthroplasty (TKA) with general anesthesia, and 2) the contribution of cognitive/brain reserve metrics these resting state functional declines. Individuals age 60 and older electing unilateral total knee arthroplasty (TKA; n = 48) and non-surgery peers with osteoarthritis (n = 45) completed baseline cognitive testing and baseline and post-surgery (post-baseline, 48-h post-surgery) brain MRI...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29402628/total-intravenous-versus-volatile-induction-and-maintenance-of-anesthesia-in-elective-carotid-endarterectomy-effects-on-cerebral-oxygenation-and-cognitive-functions
#15
Vsevolod V Kuzkov, Maxim Y Obraztsov, Oleg Y Ivashchenko, Nadezhda Y Ivashchenko, Valery M Gorenkov, Mikhail Y Kirov
OBJECTIVE: Carotid endarterectomy (CEA) is effective for the prevention of stroke, yet can be associated with a postoperative cognitive dysfunction (POCD) that may be affected by the type of anesthesia. The aim of the study was to compare the effects of total intravenous anesthesia (TIVA) with propofol to volatile induction and maintenance of anesthesia (VIMA) with sevoflurane on cerebral tissue oxygen saturation (SctO2) and POCD. DESIGN: Single-center, pilot randomized prospective study...
January 5, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29399928/the-unfold-story-of-general-anesthesia
#16
Ferenc Zsila
Inhalational anesthetics are routinely employed in the clinical practice to accomplish general anesthesia. Concerns have recently been emerged regarding deleterious impact of these volatile agents on cognitive performance, immune functions, tumor recurrence and metastasis. These agents have shown to modify the gene expression pattern as well as cell signaling in tumor cells but the underlying molecular mechanisms remain a matter of conjecture. Regulatory/signaling proteins either of cytosolic or membrane origin abundantly contain intrinsically disordered sequences, the conformational pliability of which is pivotal in their biological functions...
February 4, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29391879/combined-acupuncture-and-general-anesthesia-on-immune-and-cognitive-function-in-elderly-patients-following-subtotal-gastrectomy-for-gastric-cancer
#17
Ningke Wang, Yangwen Ou, Wenxiang Qing
This study investigated the effects of acupuncture combined with general anesthesia on postoperative immune and cognitive functions in elderly patients undergoing subtotal gastrectomy. We recruited 96 elderly patients who received anesthesia for subtotal gastrectomy and randomly divided them into control (n=48) and experimental (n=48) groups. The control group received general anesthesia and the experimental group received combined acupuncture and general anesthesia. We measured hemodynamic immediately before and after anesthesia induction, and immune observations before and after surgery...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29379356/effect-of-sevoflurane-and-halothane-anesthesia-on-cognitive-function-and-immune-function-in-young-rats
#18
Jian-Hua Qin, Xue-Rong Zhang, Liang He, Jun Zhu, Qing-Jun Ma
In the current study, we scrutinized the effect of sevoflurane and halothane on cognitive and immune function in young rats. The rats were divided into following groups: sevoflurane, halothane and sevoflurane + halothane groups, respectively. The rats were regularly treated with the pre-determined treatment. We also scrutinized the serum proinflammatory cytokines including IL-10, IL-4 and IL-2; brain level IL-1β; hippocampal neuronal apoptosis concentration were estimated. The water maze test was performed in rats for the estimation of cognitive ability...
January 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29352445/effect-of-sevoflurane-anesthesia-on-brain-is-mediated-by-lncrna-hotair
#19
Jian-Yue Wang, Yong Feng, Yan-Hong Fu, Guang-Li Liu
Postoperative cognitive dysfunction in elderly patients has been related to neurodegenerative disorders and mortality. Sevoflurane anesthesia has been implicated in both postoperative cognitive dysfunction and neurotoxicity. Given the advantages of using inhaled anesthetics like sevoflurane, it is important to understand how their usage results in neurotoxicity and subsequently devise ways to circumvent or attenuate the anesthetic-mediated induction in neurotoxicity. Long noncoding RNAs (LncRNAs) are a group of > 200 bp long RNAs and show specific spatiotemporal expression profiles...
March 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29349349/a-retrospective-analysis-of-outpatient-anesthesia-management-for-dental-treatment-of-patients-with-severe-alzheimer-s-disease
#20
Eunsun So, Hyun Jeong Kim, Myong-Hwan Karm, Kwang-Suk Seo, Juhea Chang, Joo Hyung Lee
Background: The number of patients with Alzheimer's disease is growing worldwide, and the proportion of patients requiring dental treatment under general anesthesia increases with increasing severity of the disease. However, outpatient anesthesia management for these patients involves great risks, as most patients with Alzheimer's disease are old and may show reduced cardiopulmonary functions and have cognitive disorders. Methods: This study retrospectively investigated 43 patients with Alzheimer's disease who received outpatient anesthesia for dental treatment between 2012-2017...
December 2017: Journal of Dental Anesthesia and Pain Medicine
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