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Anesthesia and cognitive function

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https://www.readbyqxmd.com/read/28497311/circulating-tnf-%C3%AE-levels-increased-and-correlated-negatively-with-igf-i-in-postoperative-cognitive-dysfunction
#1
Jue Jiang, Xiang Lv, Bing Liang, Hong Jiang
Signaling pathways of tumor necrosis factor-α (TNF-α) and insulin-like growth factor-I (IGF-I) are found to be functionally interrelated in some experimental studies. IGF-I may be involved in the pathogenesis of postoperative cognitive dysfunction (POCD). In order to investigate the possible interaction of TNF-α and IGF-I in POCD, the plasma levels of IGF-I and TNF-α were determined in 44 patients under general anesthesia. As compared with non-POCD patients, POCD patients showed increased TNF-α and decreased IGF-I levels in plasma, as well as a significant negative correlation between TNF-α and IGF-I values...
May 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28494914/the-effect-of-melatonin-on-early-postoperative-cognitive-decline-in-elderly-patients-undergoing-hip-arthroplasty-a-randomized-controlled-trial
#2
Yunxia Fan, Liang Yuan, Muhuo Ji, Jianjun Yang, Dapeng Gao
STUDY OBJECTIVE: The purpose of the present study was to investigate whether exogenous melatonin supplementation could ameliorate early postoperative cognitive decline (POCD) in aged patients undergoing hip arthroplasty with spinal anesthesia. DESIGN: Prospective cohort study. SETTING: Department of Anesthesiology, Jinling Hospital, Nanjing University, Nanjing, China. PATIENTS: One hundred and thirty-nine patients with ASA I-III, older than 65yr of age (mean age: 74...
June 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28494898/the-effect-of-desflurane-versus-propofol-anesthesia-on-postoperative-delirium-in-elderly-obese-patients-undergoing-total-knee-replacement-a-randomized-controlled-double-blinded-clinical-trial
#3
Pedro Tanaka, Stuart Goodman, Barbara R Sommer, William Maloney, James Huddleston, Hendrikus J Lemmens
STUDY OBJECTIVE: The goal of this study was to investigate the incidence of delirium, wake-up times and early post-operative cognitive decline in one hundred obese elderly patients undergoing total knee arthroplasty. DESIGN: Prospective randomized trial. SETTINGS: Operating room, postoperative recovery area, hospital wards. PATIENTS: 100 obese patients (ASA II and III) undergoing primary total knee replacement under general anesthesia with a femoral nerve block catheter...
June 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28492436/continuous-regional-anesthesia-and-inpatient-rehabilitation-for-pediatric-complex-regional-pain-syndrome
#4
Carolina Donado, Kimberly Lobo, María Fe Velarde-Álvarez, Joseph Kim, Anne Kenney, Deirdre Logan, Charles B Berde
BACKGROUND: Evidence supports treatment of pediatric complex regional pain syndromes (CRPS) with physical and occupational therapy and cognitive-behavioral therapy. Some patients have persistent pain and/or limb dysfunction despite these treatments. We performed a retrospective study of pediatric patients with CRPS treated by continuous epidural or peripheral perineural local anesthetic infusions along with inpatient rehabilitation at Boston Children's Hospital. METHODS: After approval from the institutional review board, electronic medical records were reviewed for patients treated between September 2003 and September 2014...
May 10, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28488169/cerebral-oxygen-desaturation-occurs-frequently-in-patients-with-hypertension-undergoing-major-abdominal-surgery
#5
Hongyi Li, Qiaochu Fu, Zongfang Wu, Jiaoli Sun, Anne Manyande, Hui Yang, Peng Wang
Hypertensive patients are more likely to experience latent cerebral ischemia causing regional cerebral oxygen saturation (rSO2) decrease during general anesthesia. The aim of this prospective observational study was to assess the incidence of decreased rSO2 in hypertensive patients undergoing major abdominal surgery and the perioperative factors affecting this change in rSO2. A total of 41 hypertensive patients were enrolled and stratified according to their hypertension as controlled and uncontrolled. The intraoperative rSO2 and physiological data were routinely collected...
May 9, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28479899/effects-of-vasodilator-and-esmolol-induced-hemodynamic-stability-on-early-post-operative-cognitive-dysfunction-in-elderly-patients-a-randomized-trial
#6
Sheng-Hui Sun, Lin Yang, De-Feng Sun, Yue Wu, Jun Han, Ruo-Chuan Liu, Li-Jie Wang
OBJECTIVE: To investigate the effect of continuous intravenous injection of nicardipine and/or nitroglycerin with or without esmolol on the occurrence of early post-operative cognitive dysfunction (POCD) in elderly patients. METHODS: Elderly patients (n=340) who underwent radiofrequency ablation for atrial fibrillation were randomized into five groups: A, nicardipine; B nicardipine+esmolol; C, (nitroglycerin) group; D nitroglycerin+esmolol; E (control) groups. The hemodynamic parameters were recorded, and Mini Mental State Examination was used to assess cognitive function...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28474241/reported-distress-in-patients-living-with-advanced-cancer-changes-pre-post-interdisciplinary-palliative-rehabilitation
#7
Andrea Feldstain, Neil MacDonald, Ravi Bhargava, Martin Chasen
PURPOSE: Patients are living extended life with advanced cancer making it chronic rather than imminently terminal. Literature on the experience of living with advanced cancer is emerging, indicating ongoing polysymptomatic burden, lack of information, burnout (patients and caregivers), and emotional concerns, all of which contribute to emotional distress. The interdisciplinary Ottawa Palliative Rehabilitation Program (PRP) offers a scarce clinical resource for this population. The current research aimed to explore changes in self-reported distress for patients who completed the PRP, from baseline to program completion...
May 4, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28445286/remote-ischemic-preconditioning-improves-the-cognitive-function-of-elderly-patients-following-colon-surgery-a-randomized-clinical-trial
#8
Zhenqiu He, Nan Xu, Sihua Qi
BACKGROUND: Cognitive function impairment is one of the most common complications in elderly patients after surgery, and an ideal nonpharmacological therapy has not yet been identified. Thus, we hypothesized that remote ischemic preconditioning could improve cognitive functions in elderly patients after surgery and investigated the mechanism underlying this effect. METHODS: Ninety patients classified as American Society of Anaesthesiologists (ASA) physical status of 2 or 3 and aged 65 to 75 years who were scheduled for elective colon surgery under general anesthesia were randomly allocated to either a remote ischemic preconditioning group (Group R, n = 45) or a control group (Group C, n = 45)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28435999/neonatal-propofol-anesthesia-changes-expression-of-synaptic-plasticity-proteins-and-increases-stereotypic-and-anxyolitic-behavior-in-adult-rats
#9
Desanka Milanovic, Vesna Pesic, Natasa Loncarevic-Vasiljkovic, Vladimir Avramovic, Vesna Tesic, Vesna Jevtovic-Todorovic, Selma Kanazir, Sabera Ruzdijic
Propofol is a general anesthetic commonly used in pediatric clinical practices. Experimental findings demonstrate that anesthetics induce widespread apoptosis and cognitive decline in a developing brain. Although anesthesia-mediated neurotoxicity is the most prominent during intense period of synaptogenesis, the effects of an early anesthesia exposure on the synapses are not well understood. The aim of this study was to examine the effects of neonatal propofol anesthesia on the expression of key proteins that participate in synaptogenesis and synaptic plasticity and to evaluate long-term neurobehavioral abnormalities in the mature adult brain...
April 24, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28430628/critical-role-of-matrix-metallopeptidase-9-in-postoperative-cognitive-dysfunction-and-age-dependent-cognitive-decline
#10
Jiangjiang Bi, Weiran Shan, Ailin Luo, Zhiyi Zuo
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome. Neuroinflammation is an important pathological process for POCD. However, it is not clear how systemic inflammation induced by surgery on peripheral tissues or organs is transmitted into the brain. We determined whether matrix metallopeptidase 9 (MMP9), a protein that can increase blood-brain barrier permeability, is critical in this transmission. The role of MMP9 in age-dependent cognitive decline was also determined...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28419879/challenging-the-myth-of-right-non-dominant-hemisphere-lessons-from-cortico-subcortical-stimulation-mapping-in-awake-surgery-and-surgical-implications
#11
REVIEW
Tatiana Vilasboas, Guillaume Herbet, Hugues Duffau
For a long time, the right hemisphere (RH) was considered as "non-dominant", especially in right-handers. In neurosurgical practice, this dogma resulted in the selection of awake procedure with language mapping only for lesions of the left "dominant" hemisphere. Conversely, surgery under general anesthesia (possibly with motor mapping) was usually proposed for right lesions. However, when objective neuropsychological assessments were performed, they frequently revealed cognitive and behavioral deficits following brain surgery, even in the RH...
April 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28412051/-impact-of-postoperative-cognitive-decline-in-quality-of-life-a-prospective-study
#12
Joana Borges, Joana Moreira, Adriano Moreira, Alice Santos, Fernando J Abelha
BACKGROUND: Regardless the progress in perioperative care postoperative cognitive decline (PCD) has been accepted unequivocally as a significant and frequent complication of surgery in older patients. The aim of this study was to evaluate the incidence of postoperative cognitive decline and its influence on quality of life three months after surgery. METHODS: Observational, prospective study in a Post-Anesthesia Care Unit (PACU) in patients aged above 45 years, after elective major surgery...
April 12, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28407792/treatment-of-post-anesthesia-dementia-with-perispinal-etanercept-injection-and-hyperbaric-oxygen-therapy-a-case-report
#13
Steve Best, Dan G Pavel
BACKGROUND: We report on the first case of successful treatment for post-anesthesia dementia with perispinal etanercept injection combined with hyperbaric oxygen therapy. CASE PRESENTATION: Our patient was a 77-year-old Caucasian man of Mexican ethnicity who presented to our clinic 4.5 years after a knee replacement surgery. Immediately post-surgery, the patient began to show dramatic cognitive, physical, and emotional impairment compared with his presurgical state; these symptoms were still present when he arrived at our clinic...
April 14, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28403230/isoflurane-anesthesia-promotes-cognitive-impairment-by-inducing-expression-of-%C3%AE-amyloid-protein-related-factors-in-the-hippocampus-of-aged-rats
#14
Shuai Zhang, Xueyuan Hu, Wei Guan, Li Luan, Bei Li, Qichao Tang, Honggang Fan
Isoflurane anesthesia has been shown to be responsible for cognitive impairment in Alzheimer's disease (AD) and development of AD in the older age groups. However, the pathogenesis of AD-related cognitive impairments induced by isoflurane anesthesia remains elusive. Thus, this study was designed to investigate the mechanism by which isoflurane anesthesia caused AD-related cognitive impairments. Aged Wistar rats were randomly divided into 6 groups (n = 12), 1 control group (CONT) and 5 isoflurane treated (ISO) groups (ISO 0, ISO 0...
2017: PloS One
https://www.readbyqxmd.com/read/28391017/pretreatment-with-minocycline-restores-neurogenesis-in-the-subventricular-zone-and-subgranular-zone-of-the-hippocampus-after-ketamine-exposure-in-neonatal-rats
#15
Yang Lu, P K Giri, Shan Lei, Juan Zheng, Weisong Li, Ning Wang, Xinlin Chen, Haixia Lu, Zhiyi Zuo, Yong Liu, Pengbo Zhang
Ketamine is commonly used for anesthesia in pediatric patients. Recent studies indicated that ketamine exposure in the developing brain can induce neuroapoptosis and disturb normal neurogenesis, which will result in long-lasting cognitive impairment. Minocycline exerts neuroprotection against a wide range of toxic insults in neurodegenerative disease models. In the present study, we investigated whether the disturbed neurogenesis and behavioral deficits after ketamine neonatal exposure could be alleviated by minocycline...
June 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28386342/hydrogen-rich-saline-attenuates-isoflurane-induced-caspase-3-activation-and-cognitive-impairment-via-inhibition-of-isoflurane-induced-oxidative-stress-mitochondrial-dysfunction-and-reduction-in-atp-levels
#16
Cheng Li, Lengchen Hou, Dan Chen, Fuqing Lin, Tao Chang, Mengzhu Li, Lingling Zhang, Xiaoyin Niu, Huiying Wang, Shukun Fu, Junhua Zheng
OBJECTIVES: The inhaled general anesthetic isoflurane has been shown to induce caspase-3 activation in vitro and in vivo. The underlying mechanisms and functional consequences of this activity remain unclear. Isoflurane can induce caspase-3 activation by causing accumulation of reactive oxygen species (ROS), mitochondrial dysfunction, and reduction in adenosine triphosphate (ATP) levels. This study aimed to investigate the protective effect of hydrogen, a novel antioxidant, against isoflurane-induced caspase-3 activation and cognitive impairment...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28372661/effect-of-propofol-sevoflurane-and-isoflurane-on-postoperative-cognitive-dysfunction-following-laparoscopic-cholecystectomy-in-elderly-patients-a-randomized-controlled-trial
#17
Ying-Jie Geng, Qing-Hua Wu, Rui-Qin Zhang
STUDY OBJECTIVE: To compare the incidence of postoperative cognitive dysfunction (POCD) in elderly surgical patients (>60years) receiving different anesthetics (propofol, sevoflurane, or isoflurane) and to identify potential biomarkers of POCD in this patient population. DESIGN: Prospective, randomized, double-blind clinical trial. SETTING: University-affiliated teaching hospital. PATIENTS: One hundred and fifty elderly patients scheduled for laparoscopic cholecystectomy...
May 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28338180/influence-of-dexmedetomidine-to-cognitive-function-during-recovery-period-for-children-with-general-anesthesia
#18
Z-M Jia, H-N Hao, M-L Huang, D-F Ma, X-L Jia, B Ma
OBJECTIVE: We studied the influence of Dexmedetomidine on cognitive function in children during the recovery period of general anesthesia. PATIENTS AND METHODS: Ninety-three children who underwent general anesthesia were selected and randomly divided into (1) the control group, (2) the dexmedetomidine group, and (3) the dezocine group. Fentanyl, propofol, and rocuronium were used in all patients to induce anesthesia, while sevoflurane inhalation and propofol were used to maintain anesthesia...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28317003/peri-operative-inflammatory-cytokines-in-plasma-of-the-elderly-correlate-in-prospective-study-with-postoperative-changes-in-cognitive-test-scores
#19
R Kline, E Wong, M Haile, S Didehvar, S Farber, A Sacks, E Pirraglia, M J de Leon, A Bekker
Increasingly, postoperative cognitive dysfunction (POCD) is recognized as a complication after surgery in the elderly; but it's etiology remains unclear. Here we examine changes in cytokine levels during both the pre-operative and postoperative period, comparing them with long term variation in cognitive test scores. Forty-one patients aged 65 and older undergoing major surgery with general anesthesia were recruited after written consent in this IRB approved study. Thirty went on to complete this prospective, non-interven-tional and non-randomized study...
August 2016: International Journal of Anesthesiology & Research
https://www.readbyqxmd.com/read/28298935/cardioprotection-of-electroacupuncture-for-enhanced-recovery-after-surgery-on-patients-undergoing-heart-valve-replacement-with-cardiopulmonary-bypass-a-randomized-control-clinical-trial
#20
Fangxiang Zhang, Xiangdi Yu, Hong Xiao
We attempted to investigate cardioprotection of electroacupuncture (EA) for enhanced recovery after surgery on patients undergoing heart valve replacement with cardiopulmonary bypass. Forty-four patients with acquired heart valve replacement were randomly allocated to the EA group or the control group. Patients in the EA group received EA stimulus at bilateral Neiguan (PC6), Ximen (PC4), Shenting (GV24), and Baihui (GV20) acupoints twenty minutes before anesthesia induction to the end of surgery. The primary end point was cardioprotection effect of electroacupuncture postoperatively and the secondary endpoints were quality of recovery and cognitive functioning postoperatively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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