keyword
MENU ▼
Read by QxMD icon Read
search

Paraquat poisoning

keyword
https://www.readbyqxmd.com/read/28719757/the-plasma-concentration-of-muc5b-is-associated-with-clinical-outcomes-in-paraquat-poisoned-patients
#1
Andrew A Monte, Hao Sun, Anna Malin Rapp-Olsson, Fahim Mohamed, Indika Gawarammana, Nicholas A Buckley, Christopher M Evans, Ivana V Yang, David A Schwartz
No abstract text is available yet for this article.
July 18, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28704509/effects-of-hemoperfusion-and-continuous-renal-replacement-therapy-on-patient-survival-following-paraquat-poisoning
#2
Yadong Wang, Yao Chen, Lu Mao, Guangju Zhao, Guangliang Hong, Mengfang Li, Bin Wu, Xiaorong Chen, Meng Tan, Na Wang, Zhongqiu Lu
Mortality in patients with paraquat (PQ) poisoning is related to plasma PQ levels. Concentrations lower than 5,000 ng/mL are considered critical but curable. This study assessed the effects of hemoperfusion (HP) and continuous renal replacement therapy (CRRT) on the survival of PQ-poisoned patients with plasma PQ levels below 5,000ng/mL. We analyzed the records of 164 patients with PQ poisoning who were treated at the First Affiliated Hospital of Wenzhou Medical University in China between January 2011 and May 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28699703/a-positive-feedback-loop-promotes-hif-1%C3%AE-stability-through-mir-210-mediated-suppression-of-runx3-in-paraquat-induced-emt
#3
Yong Zhu, Jinfeng Wang, Xiaoxiao Meng, Hui Xie, Jiuting Tan, Xinkun Guo, Peng Han, Ruilan Wang
Irreversible pulmonary fibrosis induced by paraquat (PQ) poisoning is the major cause of death in patients with PQ poisoning. The epithelial-mesenchymal transition (EMT) is postulated to be one of the main mechanisms of pulmonary fibrosis. Here, we investigated the role of miR-210 in PQ-induced EMT and its relationship with hypoxia-inducible factor-1α (HIF-1α). Western blotting, immunofluorescence, immunoprecipitation and other methods were used in this study. We found that miR-210 expression was significantly increased after PQ poisoning, and it may be regulated by HIF-1α...
July 12, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28672896/predictive-values-of-urine-paraquat-concentration-dose-of-poison-arterial-blood-lactate-and-apache-ii-score-in-the-prognosis-of-patients-with-acute-paraquat-poisoning
#4
Xiao-Wei Liu, Tao Ma, Lu-Lu Li, Bo Qu, Zhi Liu
The present study investigated the predictive values of urine paraquat (PQ) concentration, dose of poison, arterial blood lactate and Acute Physiology and Chronic Health Evaluation (APACHE) II score in the prognosis of patients with acute PQ poisoning. A total of 194 patients with acute PQ poisoning, hospitalized between April 2012 and January 2014 at the First Affiliated Hospital of P.R. China Medical University (Shenyang, China), were selected and divided into survival and mortality groups. Logistic regression analysis, receiver operator characteristic (ROC) curve analysis and Kaplan-Meier curve were applied to evaluate the values of urine paraquat (PQ) concentration, dose of poison, arterial blood lactate and (APACHE) II score for predicting the prognosis of patients with acute PQ poisoning...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28640126/prolonged-methylprednisolone-therapy-after-the-pulse-treatment-for-patients-with-moderate-to-severe-paraquat-poisoning-a-retrospective-analysis
#5
Jie Gao, ShunYi Feng, Jian Wang, SiYuan Yang, Yong Li
This retrospective study aims to evaluate the effect of prolonged methylprednisolone (MP) therapy on the mortality of patients with moderate-to-severe paraquat (PQ) poisoning after the pulse treatment.We performed a retrospective analysis of patients with acute moderate-to-severe PQ poisoning that were admitted to the emergency department from May 2012 to August 2016. Out of 138 patients, 60 were treated with pulse treatment (15 mg kg day MP for 3 days) and 78 were treated with prolonged MP therapy after pulse treatment (15 mg kg day MP for 3 days; afterward, the dosage was reduced in half every 2 days, and the MP therapy was terminated until 0...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28627340/-experimental-study-on-formation-of-neutrophil-extracellular-traps-in-human-peripheral-blood-induced-by-paraquat-in-vitro
#6
Wei Jin, Jian Lu, Hui Xie, Yiqun Jiang, Xiaoxiao Meng, Yong Zhu, Ruilan Wang
OBJECTIVE: To explore whether paraquat (PQ) can induce the formation of neutrophil extracellular traps (NETs) in human peripheral blood. METHODS: Neutrophils were isolated from healthy human peripheral blood, and the cells were identified by hematoxylin-eosin (HE) strain. The cells were treated with different concentrations of PQ [0 (as control), 200, 400, 600, 800, 1 000 and 1 200 μmol/L], and the cell viability was measured by cell proliferation and CCK-8 cytotoxicity detection kit, and the median lethal concentration of PQ was selected...
March 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28627339/-evaluation-of-adsorption-effect-of-activated-charcoal-on-oral-paraquat-poisoning-an-experimental-study-on-large-animal
#7
Baisheng Sun, Yuezhong He, Yuhao Pei, Cong Zhang, Xigang Zhang, Zhan Yang
OBJECTIVE: To study the adsorption effect of activated charcoal suspension on paraquat (PQ) in gastrointestinal tract of beagles exposed to PQ. METHODS: Twenty healthy male beagles were randomly divided into experimental group and control group, with 6 beagles in each group. 20% PQ solution (a dose of 30 mg/kg) was prescribed through stomach for beagles in both groups. After exposure to PQ for 30 minutes, the beagles in experimental group were given activated charcoal suspension (1...
March 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28624451/rapamycin-protects-against-paraquat-induced-pulmonary-fibrosis-activation-of-nrf2-signaling-pathway
#8
Yiheng Xu, Wenlin Tai, Xiaoyuan Qu, Wenjuan Wu, ZhenKun Li, Shuhao Deng, Chanthasone Vongphouttha, Zhaoxing Dong
Paraquat (PQ) is a widely used herbicide indeveloping countries worldwide, and pulmonary fibrosis is one of the most typical features of PQ poisoning. The molecular mechanism of PQ toxicity especially how to treat PQ-induced pulmonary fibrosis is still largely unknown. In animal model of pulmonary fibrosis, we used HE staining, western blotting assay and Real-time PCR assay to analyze the effects of rapamycin on the PQ-induced epithelial mesenchymal transition (EMT). We found that PQ induced the pulmonary fibrosis using HE staining and Masson's staining, and up-regulated the activity of HYP and the mRNA expressions of Collagen I and III (COL-1and COL-3) in pulmonary tissues...
August 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28614921/-the-study-of-using-cordyceps-astragalus-salvia-miltiorrhiza-to-treat-acute-lung-injury-induced-by-paraquat-poisoning-in-rats
#9
Q L Li, J L Liu, J R Wang, X D Jian, B T Kan, Z C Zhang
Objective: To study the therapy of cordyceps-astragalus-salvia miltiorrhiza in treating acute lung injury and pulmonary interstitial fibrosis induced by paraquat poisoning. Methods: All 120 adult Wister male rats were randomly assigned to three groups, the paraquat poisoning group (rats were intragastric administration paraquat 50 mg/kg body weight once at the beginning) , the cordyceps-astragalus-salvia miltiorrhiza therapy group (rats were given cordyceps-astragalus-salvia miltiorrhiza 90 mg/kg body weight intragastric administration half an hour after paraquat was given, then the same dose was given once a day) ; control group (rats were intragastric administration with physiological saline) ...
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28609698/clinical-screening-of-paraquat-in-plasma-samples-using-capillary-electrophoresis-with-contactless-conductivity-detection-towards-rapid-diagnosis-and-therapeutic-treatment-of-acute-paraquat-poisoning-in-vietnam
#10
Anh Phuong Vu, Thi Ngan Nguyen, Thi Trang Do, Thu Ha Doan, Tran Hung Ha, Thi Thao Ta, Hung Long Nguyen, Peter C Hauser, Thi Anh Huong Nguyen, Thanh Duc Mai
The employment of a purpose-made capillary electrophoresis (CE) instrument with capacitively coupled contactless conductivity detection (C(4)D) as a simple and cost-effective solution for clinical screening of paraquat in plasma samples for early-stage diagnosis of acute herbicide poisoning is reported. Paraquat was determined using an electrolyte composed of 10mM histidine adjusted to pH 4 with acetic acid. A detection limit of 0.5mg/L was achieved. Good agreement between results from CE-C(4)D and the confirmation method (HPLC-UV) was obtained, with relative errors for the two pairs of data better than 20% for 31 samples taken from paraquat-intoxicated patients...
June 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28591706/predictors-of-acute-kidney-injury-after-paraquat-intoxication
#11
Cheng-Hao Weng, Hui-Hsiang Chen, Ching-Chih Hu, Wen-Hung Huang, Ching-Wei Hsu, Jen-Fen Fu, Wey-Ran Lin, I-Kwan Wang, Tzung-Hai Yen
Paraquat intoxication is characterized by multi-organ failure, causing substantial mortality and morbidity. Many paraquat patients experience acute kidney injury (AKI), sometimes requiring hemodialysis. We observed 222 paraquat-intoxicated patients between 2000 and 2012, and divided them into AKI (n = 103) and non-AKI (n = 119) groups. The mortality rate was higher for AKI than non-AKI patients (70.1% vs. 40.0%, P < 0.001). Patients with AKI had a longer time to hospital arrival (P = 0.003), lower PaO2 (P = 0...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28541002/effects-of-paraquat-ban-on-herbicide-poisoning-related-mortality
#12
Dong Ryul Ko, Sung Phil Chung, Je Sung You, Soohyung Cho, Yongjin Park, Byeongjo Chun, Jeongmi Moon, Hyun Kim, Yong Hwan Kim, Hyun Jin Kim, Kyung Woo Lee, SangChun Choi, Junseok Park, Jung Soo Park, Seung Whan Kim, Jeong Yeol Seo, Ha Young Park, Su Jin Kim, Hyunggoo Kang, Dae Young Hong, Jung Hwa Hong
PURPOSE: In Korea, registration of paraquat-containing herbicides was canceled in November 2011, and sales thereof were completely banned in November 2012. We evaluated the effect of the paraquat ban on the epidemiology and mortality of herbicide-induced poisoning. MATERIALS AND METHODS: This retrospective study analyzed patients treated for herbicide poisoning at 17 emergency departments in South Korea between January 2010 and December 2014. The overall and paraquat mortality rates were compared pre- and post-ban...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28540206/acute-kidney-injury-from-different-poisonous-substances
#13
Rubina Naqvi
AIM: To report our experience of acute kidney injury (AKI) developed after exposure to poisonous substance. METHODS: Retrospective study where data was collected from case records of patients coming to this institute during January 1990 to May 2016. This institution is a tertiary care center for renal care in the metropolitan city of Karachi, Pakistan. History of ingested substance, symptoms on presentation, basic laboratory tests on arrival, mode of treatment and outcome were recorded from all patients and are presented here...
May 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28533543/time-dependent-haemoperfusion-after-acute-paraquat-poisoning
#14
Hao-Ru Wang, Jian Pan, An-Dong Shang, Yuan-Qiang Lu
Early haemoperfusion (HP) therapy has been found to be very effective in acute paraquat (PQ) poisoning, but the effective rescue window is still uncertain. Demographic data and the type of therapies administered of 621 patients were included as confounding factors in this retrospective study. After receiver operating characteristic curve analysis and intra-group/subgroup analysis, the initiation of glucocorticoid therapy within 3 hrs of exposure with a second treatment given <21 hrs after exposure, HP initiated within 4 hrs of exposure with a second treatment given <20 hrs after exposure, the appearance of pulmonary lesions ≤8 days after exposure and six other variables were used in a multiple analysis...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28514303/continuous-venovenous-hemofiltration-in-the-management-of-paraquat-poisoning-a-meta-analysis-of-randomized-controlled-trials
#15
REVIEW
Guodong Lin, Jianhai Long, Yuan Luo, Yongan Wang, Qiu Zewu
BACKGROUND: Paraquat (PQ) poisoning is a widespread occurrence, especially in underdeveloped areas. The treatment of PQ poisoning has always been difficult, and there is currently no definite effective treatment. Continuous venovenous hemofiltration (CVVH) treatment for PQ poisoning has been widely used in clinical practice; however, its effect remains uncertain. Accordingly, the purpose of this meta-analysis was to evaluate the efficacy of CVVH in the treatment of PQ poisoning. METHODS: We searched for relevant trials using PubMed, Embase, the Cochrane Library, and 3 Chinese databases, the Chinese BioMedical Literature Database, National Knowledge Infrastructure Database, and Wanfang Database...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28508189/the-contribution-of-superoxide-radical-to-cadmium-toxicity-in-e-coli
#16
Milini Thomas, Ludmil Benov
Numerous reports suggest the involvement of oxidative stress in cadmium toxicity, but the nature of the reactive species and the mechanism of Cd-induced oxidative damage are not clear. In this study, E. coli mutants were used to investigate mechanisms of Cd toxicity. Effects of Cd on metabolic activity, production of superoxide radical by the respiratory chain, and induction of enzymes controlled by the soxRS regulon were investigated. In E. coli, the soxRS regulon controls defense against O2·(-)and univalent oxidants...
May 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28501785/experimental-study-of-sucralfate-intervention-for-paraquat-poisoning-in-rats
#17
Zhu Junbo, Yu Yongtao, Li Hongbo, Zheng Fenshuang, Lin Ruyun, Yang Chun'ai
OBJECTIVE: This study explored the effects of sucralfate intervention as a novel treatment for paraquat (PQ) poisoning in Sprague-Dawley (SD) rats. METHODS: After PQ poisoning, the SD rats were randomly divided into the PQ control group (treated with normal saline), the sodium bicarbonate (SB) treatment group, and the sucralfate (LTL) treatment group. Then, the rats were administered normal saline, sodium bicarbonate solution, or sucralfate suspension as an intervention by gastric lavage...
July 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28492119/paraquat-poisoning-acute-lung-injury-a-missed-diagnosis
#18
Sipho D Ntshalintshali, Thandekile C Manzini
Paraquat is a herbicide of great toxicological importance because it is associated with high mortality rates, mainly due to respiratory failure. We report the case of a 28-year-old man admitted to the casualty department at Ngwelezana Hospital, Empangeni, KwaZulu-Natal, South Africa, with a history of vomiting and abdominal pain after ingestion of ~100 mL of an unknown substance, later identified as paraquat, together with an unknown amount of alcohol, in a suicide attempt. He developed respiratory distress associated with lung parenchymal infiltrates that required ventilatory support and later a spontaneous pneumothorax, and died in the intensive care unit...
April 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28480221/liver-x-receptor-agonist-to901317-attenuates-paraquat-induced-acute-lung-injury-through-inhibition-of-nf-%C3%AE%C2%BAb-and-jnk-p38-mapk-signal-pathways
#19
Xiao Hu, Haitao Shen, Yu Wang, Min Zhao
Paraquat (PQ) is a widely used herbicide with extremely high poisoning mortality mostly from acute lung injury (ALI) or progressive pulmonary fibrosis. Toxicity mechanisms remain unclear, but a redox cycling process that generates reactive oxygen species (ROS) is involved, as are inflammation and cell apoptosis. We established an ALI mouse model by intraperitoneal injection of PQ (28 mg/kg) and then investigated the effects of a potent liver X receptor (LXR) agonist, TO901317 (5 or 20 mg/kg), injected intraperitoneally 30 min after PQ administration...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28480199/a-rare-case-of-epilepsy-and-acute-pancreatitis-induced-by-severe-paraquat-poisoning
#20
Hongxia Dong, Xiaobo Peng, Zewu Qiu
Paraquat can lead to injury of multiple organs. As there is no specific treatment for paraquat poisoning, it represents a serious clinical problem. Antioxidants are required to treat oxidative stress in paraquat poisoning and paraquat-induced injury. In this study, we report on successful treatment of a rare case of epilepsy and acute pancreatitis caused by paraquat poisoning. A 29-year-old woman at our hospital presented with a 13-day history of nausea and vomiting after ingesting 20 mL of paraquat (20% W/V)...
April 2017: Annals of Translational Medicine
keyword
keyword
104779
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"