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Paraquat poisoning

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https://www.readbyqxmd.com/read/28241698/-value-of-base-excess-in-predicting-the-prognosis-of-patients-with-paraquat-poisoning
#1
X W Kang, H Tong, K Q Cao, Q F Mo, L W Li, G L Hong, L Mo, D Li, G J Zhao, Z Q Lu
Objective: To explore prognostic factors of acute paraquat poisoning (APP) , analyze the correlation between base excess (BE) and plasma concentration of paraquat (C-PQ) and discuss BE level in evalua-tion of prognosis of acute paraquat poisoning patients. Methods: We retrospectively selected 84 APP patients who admitted to Emergency Intensive Care Unit (EICU) of our hospital from 2009.9.1 to 2015.8.31.Clinical data from 84 APP patients were analyzed. BE、C-PQ、time of gastric lavagesince ingestion、time of hemoperfusion since ingestion、severity index of paraquat poisoning (SIPP) 、white blood cell (WBC) 、percentage of neutrophils (N%) 、hemoglobin (HB) 、creatinine (Cr) 、alanine aminotransferase (ALT) 、aspartate aminotransferase (AST) 、partial pressure of oxygen (PaO(2)) 、partial pressure of carbon dioxide (PaCO(2)) and other laboratory parameters were measured...
January 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28131803/myd88-gene-knockout-attenuates-paraquat-induced-acute-lung-injury
#2
Haitao Shen, Na Wu, Yu Wang, Feng Guo, Lianghong Chen, Zhigang Zhang, Dong Jia, Min Zhao
OBJECTIVE: This study investigated the role of myeloid differentiation factor 88 (MyD88) in paraquat-induced acute lung injury (ALI). METHODS: C57BL mice were divided into the control group, paraquat group, MyD88 knockout (KO) group, and MyD88 KO plus paraquat group. At 48h after paraquat poisoning, serum and lung tissues were collected. ELISA was employed to detect tumor necrosis factor-α (TNF-α) and interleukine-1β (IL-1β) contents in serum. Lung tissues were processed for hematoxylin-eosin staining, followed by histological scoring...
January 25, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28123623/intravenous-injection-of-xuebijing-attenuates-acute-kidney-injury-in-rats-with-paraquat-intoxication
#3
Jia-Jun Xu, Jian-Tao Zhen, Li Tang, Qing-Ming Lin
BACKGROUND: The study aimed to investigate the therapeutic benefits of intravenous Xuebijing on acute kidney injury (AKI) in rats with paraquat intoxication. METHODS: Male Sprague-Dawley rats were randomly divided equally into three groups: sham group (n=8), paraquat group (n=8) and Xuebijing-treated group (n=8) using a random number table. The rats were intraperitoneally injected with 50 mg/kg of paraquat. One hour after paraquat administration, the rats were treated intravenously with Xuebijing (8 mL/kg)...
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28070046/-dose-effect-relationship-between-vitamin-c-and%C3%A2-paraquat-poisoning-rats
#4
Baoling Wen, Lei Yu, Yan Fang, Xiaolong Wang
To explore the dose-effect relationship between vitamin C and paraquat (PQ) poisoning rats.
 Methods: A total of 40 Sprague-Dawley (SD) rats were randomly divided into 4 groups: a control group, a PQ poisoning group, a vitamin C group 1 and a vitamin C group 2 (n=10 in each group). 150 mg/kg PQ was perfused into rat stomach to establish PQ poisoning rat model. In PQ poisoning group, 30 mg/kg methylprednisolone and 2.5 mg/kg cyclophosphamide were injected peritoneally on the basis of PQ poisoning rat model...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27884773/an-intelligent-prognostic-system-for-analyzing-patients-with-paraquat-poisoning-using-arterial-blood-gas-indexes
#5
Lufeng Hu, Feiyan Lin, Huaizhong Li, Changfei Tong, Zhifang Pan, Jun Li, Huiling Chen
The arterial blood gas (ABG) test is used to assess gas exchange in the lung, and the acid-base level in the blood. However, it is still unclear whether or not ABG test indexes correlate with paraquat (PQ) poisoning. This study investigates the predictive value of ABG tests in prognosing patients with PQ poisoning; it also identifies the most significant indexes of the ABG test. An intelligent machine learning-based system was established to effectively give prognostic analysis of patients with PQ poisoning based on ABG indexes...
November 21, 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27883937/atorvastatin-protected-from-paraquat-induced-cytotoxicity-in-alveolar-macrophages-via-down-regulation-of-tlr-4
#6
Nazli Alizadeh-Tabrizi, Hassan Malekinejad, Soheil Varasteh, Hadi Cheraghi
The current study designed to clarify the mechanism of paraquat-induced cytotoxicity and protective effects of Atorvastatin on freshly isolated alveolar macrophages (AMs). AMs were collected via bronchoalveolar lavage and exposed to various concentrations of paraquat in the presence and absence of atorvastatin for 24h. Cell viability, myeloperoxidase activity; nitric oxide generation and total antioxidant capacity were assessed. Expression of TLR-4 at mRNA and protein levels were studied by using PCR and western blot methods Atorvastatin enhanced the paraquat-reduced cell viability and reduced the paraquat-induced myeloperoxidase activity and nitric oxide production...
January 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27866563/-recent-advance-of-cytokines-in-the-pathogenesis-of-lung-injury-induced-by-paraquat-poisoning
#7
W Y Fang, X S Xie, S G Feng
No abstract text is available yet for this article.
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27866555/-two-cases-of-acute-poisoning-of-paraquat-with-dursban-and-paraquat-with-bromadiolone
#8
H B Zhou, M Xia
No abstract text is available yet for this article.
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27866548/-effect-of-heme-oxygenase-1-transduced-by-cell-penetrating-peptide-pep-1-on-renal-injury-in-rats-with-acute-paraquat-poisoning
#9
X Wang, Y X Zhao, H X Li, A J Li, S Liu, H M Chen, W Z Cui
Objective: To study the effects of heme oxygenase-1 transduced by cell penetrating peptide PEP-1 on renal injury in acute paraquat-induced rats. Methods: The fusion protein PEP-1/HO-1 was manufactured by genetic engineering methods. One hundred and twenty-six healthy adult Sprague-Dawley (SD) rats (63 male, 63 female) were randomly divided into three groups: (1) Control group: 42 rats, (2) Poisoned group: 42 rats, (3) PEP-1/HO-1 intervention group: 42 rats. The rats in Poisoned group and intervention group were treated intraperitoneally with paraquat (25 mg/kg) deliquated with normal saline...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27824090/prognostic-value-of-hematological-parameters-in-patients-with-paraquat-poisoning
#10
Deng-Chuan Zhou, Hong Zhang, Zhi-Ming Luo, Qi-Xing Zhu, Cheng-Fan Zhou
Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 2010 to December 2015 at the First Affiliated Hospital, Anhui Medical University (Hefei, China). A total of 202 patients were included in the study, and the 30-day mortality was 51.98%. Leukocyte, neutrophil counts and neutrophil-lymphocyte ratio (NLR) were significantly higher in non-survivors than in survivors...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27728610/clinical-profile-of-paraquat-poisonings
#11
K Prabhath Kiran Reddy, Manthappa M
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728609/comparision-of-clinical-outcome-of-paraquat-poisoning-in-patients-treated-with-and-without-methylprednisolone
#12
Harikrishna A, Chandrashekar V, Gururaj N, Srilatha
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728607/fanconi-syndrome-in-paraquat-poisoning
#13
Narendran Krishnamoorthi, Christopher C Pais, Muralidhara Yadiyal B, Pradeep Kumar Shenoy, Riffat Abdulaziz
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27689124/acute-kidney-injury-in-patients-with-paraquat-intoxication-a-case-report-and-review-of-the-literature
#14
Afshin Safaei Asl, Peyman Dadashzadeh
Paraquat and diquat are classified as bipyridyl compounds not only leads to acute organ damage, but also to a variety of complications. Patients with severe paraquat-induced poisoning may succumb to multiple organ failure involving the circulatory and respiratory systems. Deliberate self-poisoning with paraquat continues to be a major public health concern in many developing countries. At present there is no specific antidote to paraquat poisoning, hence the need to more focus on prevention and in cases of poisoning aggressive decontamination to prevent further absorption...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27682493/-clinical-effect-of-compound-monoammonium-glycyrrhizinate-combined-with-dandelion-in-treatment-of-acute-paraquat-poisoning
#15
Y Zhao, X D Jian
Objective: To investigate the clinical effect of compound monoammonium glycyrrhizinate combined with dandelion in the treatment of acute paraquat poisoning. Methods: A total of 80 patients with acute paraquat poisoning who were admitted to our hospital were enrolled as study subjects and randomly divided into routine treatment group (38 patients) and traditional Chinese medicine (TCM) group (42 patients) . The patients in the TCM group were given compound monoammonium glycyrrhizinate and dandelion in addition to the treatment in the control group...
July 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27682488/-risk-factors-for-pulmonary-fibrosis-in-patients-with-paraquat-poisoning
#16
J Y Liu, Q M Liu, Y J Guo, D J Lin
Objective: To investigate the risk factors for pulmonary fibrosis in patients with paraquat (PQ) poisoning. Methods: A total of 120 patients with PQ poisoning who were admitted from January 2012 to December 2014 were enrolled. According to the presence or absence of pulmonary fibrosis, the patients were divided into non-pulmonary fibrosis group (67 patients) and pulmonary fibrosis group (53 patients) . The Acute Physiology and Chronic Health Evaluation II (APACHE II) score was obtained on days 1 and 3 of poisoning...
July 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27682485/-an-analysis-of-the-clinical-and-epidemiological-characteristics-of-acute-poisoning-patients-in-a-general-hospital
#17
Y H Hou, Q Zhao, Y X Wu, T T Hu, Y Chen, Y T You, X W Kang, G L Hong, Z Q Lu
Objective: To analyze the clinical and epidemiological characteristics of acute poisoning patients in a general hospital, then to provide a reference for the prevention and treatment of acute poisoning in the future. Methods: A retrospective analysis was made on the clinical data of 660 patients with acute poisoning admitted in emergency medical center of the First Affiliated Hospital of Wenzhou Medical University from July 2009 to May 2015. Results: More men than women in 660 cases with acute poisoning(the ratio of male to female was 1...
July 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27545861/effect-of-mdr1-gene-polymorphisms-on-mortality-in-paraquat-intoxicated-patients
#18
Hak Jae Kim, Hyung-Ki Kim, Jun-Tack Kwon, Sun-Hyo Lee, Sam El Park, Hyo-Wook Gil, Ho-Yeon Song, Sae-Yong Hong
Paraquat is a fatal herbicide following acute exposure. Previous studies have suggested that multidrug resistance protein 1 (MDR1) might help remove paraquat from the lungs and the kidney. MDR1 single-nucleotide polymorphisms (SNPs) are involved in the pharmacokinetics of many drugs. The purpose of this study was to determine whether MDR1 SNPs were associated with the mortality in paraquat intoxicated patients. We recruited 109 patients admitted with acute paraquat poisoning. They were genotyped for C1236T, G2677T/A, and C3435T single-nucleotide polymorphisms (SNPs) of MDR1 gene...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27514433/-progress-on-predictors-of-patients-with-acute-paraquat-poisoning
#19
D C Zhou, X Ling, C F Zhou
No abstract text is available yet for this article.
May 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27514411/-clinical-value-of-serum-presepsin-scd14-st-concentration-measurement-in-patients-with-pesticide-poisoning
#20
X Gao, B Y Zhu, W Z Wang, J Q He, D L Han, Y J Liu, H Meng, Q M Xiao, X T Liu, Y Y Han
OBJECTIVE: To investigate the value of serum presepsin concentration measurement in the clinical diagnosis and treatment of patients with pesticide poisoning patients. METHODS: A total of 160 patients with pesticide poisoning were enrolled as study subjects and divided into moderate organophosphate pesticide poisoning group (40 patients) , severe organophosphate pesticide poisoning group (40 patients) , abamectin pesticide poisoning group (40 patients) , and paraquat poisoning group (40 patients)...
May 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
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