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Paraquat poisoning

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https://www.readbyqxmd.com/read/29116999/treatment-outcome-of-combined-continuous-venovenous-hemofiltration-and-hemoperfusion-in-acute-paraquat-poisoning-a-prospective-controlled-trial
#1
Changbin Li, Dayong Hu, Wen Xue, Xinhua Li, Zhen Wang, Zisheng Ai, Yaxiang Song, Xinying Liu, Jiafeng Cheng, Shuling Fan, Limin Zhao, Liya Wang, Chandra Mohan, Ai Peng
OBJECTIVES: To investigate whether combined continuous venovenous hemofiltration and hemoperfusion among paraquat-poisoned patients would improve survival. DESIGN: Prospective, controlled interventional study over 4 years. SETTING: Single, tertiary, academic medical center. PATIENTS: We recruited patients admitted to Shanghai Tenth People's Hospital within 48 hours after paraquat ingestion. Exclusions were under 14 years old, ingestion of paraquat with other toxicants, pregnant, a history of chronic pulmonary disease, psychosis, hyperthyroidism, or diabetes with impaired liver or renal function...
November 7, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29115090/urine-methyl-hippuric-acid-levels-in-acute-pesticide-poisoning-estimation-of-ingested-xylene-volume-and-association-with-clinical-outcome-parameters
#2
Chi Young Choi, NamJun Cho, Su Yeon Park, Samel Park, Hyo Wook Gil, Sae Yong Hong
To determine the relationship between the oral ingestion volume of xylene and methyl hippuric acid (MHA) in urine, we measured MHA in 11 patients whose ingested xylene volume was identified. The best-fit equation between urine MHA and ingested amount of xylene was as follows: y (ingested amount of xylene, mL/kg) = -0.052x² + 0.756x (x = MHA in urine in g/g creatinine). From this equation, we estimated the ingested xylene volume in 194 patients who had ingested pesticide of which the formulation was not available...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29104250/a-pilot-study-in-cameroon-to-understand-safe-uses-of-pesticides-in-agriculture-risk-factors-for-farmers-exposure-and-management-of-accidental-cases
#3
Guy Bertrand Pouokam, William Lemnyuy Album, Alice S Ndikontar, Mohamed El Hady Sidatt
Chemical pesticides are widely used in Cameroon for agricultural production. In 2015, more than 600 pesticide products were approved for use in various foodstuffs. Much misuse of these chemicals by farmers has been documented in rural and urban settings. This pilot study aims to contribute to the improvement of the health of the population and the environmental preservation by identifying pesticide-poisoning cases, the most incriminated products and critical risk factors of exposure. Questionnaires were administered to pesticide vendors, farmers and health personnel, and observations made on farmers' practices at their work places...
November 1, 2017: Toxics
https://www.readbyqxmd.com/read/29099997/early-metabolome-profiling-and-prognostic-value-in-paraquat-poisoned-patients-based-on-ultra-performance-liquid-chromatography-coupled-to-quadrupole-time-of-flight-mass-spectrometry
#4
Lufeng Hu, Guangliang Hong, Yahui Tang, Xianqin Wang, Congcong Wen, Feiyan Lin, Zhongqiu Lu
Paraquat (PQ) has caused countless deaths throughout the world. There remains no effective treatment for PQ poisoning. Here we study the blood metabolome of PQ-poisoned patient using ultra performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS). Patients were divided into groups according blood PQ concentration. Healthy subjects served as controls. Metabolic features were statistically analyzed using multivariate pattern-recognition techniques to identify the most important metabolites...
November 3, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29098875/high-dose-immunosuppression-to-prevent-death-after-paraquat-self-poisoning-a-randomised-controlled-trial
#5
Indika Gawarammana, Nicholas A Buckley, Fahim Mohamed, Kamal Naser, K Jeganathan, P L Ariyananada, Klintean Wunnapuk, Timothy A Dobbins, John A Tomenson, Martin F Wilks, Michael Eddleston, Andrew H Dawson
CONTEXT: Intentional self-poisoning with the herbicide paraquat has a very high case-fatality and is a major problem in rural Asia and Pacific. OBJECTIVES: We aimed to determine whether the addition of immunosuppression to supportive care offers benefit in resource poor Asian district hospitals. MATERIALS AND METHODS: We performed a randomised placebo-controlled trial comparing immunosuppression (intravenous cyclophosphamide up to 1 g/day for two days and methylprednisolone 1 g/day for three days, and then oral dexamethasone 8 mg three-times-a-day for 14 days) with saline and placebo tablets, in addition to standard care, in patients with acute paraquat self-poisoning admitted to six Sri Lankan hospitals between 1st March 2007 and 15th November 2010...
November 3, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29096617/effect-of-prohibiting-the-use-of-paraquat-on-pesticide-associated-mortality
#6
Jinyong Kim, Sang Do Shin, Seungmin Jeong, Gil Joon Suh, Young Ho Kwak
BACKGROUND: Paraquat is associated with a high rate of fatalities in acute poisoning. This study aimed to examine the association between the national public health policy that banned the use of paraquat and the incidence of pesticide-associated mortality. METHODS: All external causes of death from 2009 to 2013 of Korea were analyzed. The intervention was a national public health policy that annulled the authorized use (2011) and banned the purchase of paraquat (2012)...
November 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29082819/prognostic-comparison-of-goal-oriented-hemoperfusion-and-routine-hemoperfusion-combined-with-continuous-venovenous-hemofiltration-for-paraquat-poisoning
#7
Xuming Zhao, Yan Xiao, Jianliang Zhu, Zhiping Xu, Lijun Liu, Jinsong Zhang
Objective To investigate the impact of goal-oriented hemoperfusion (HP) with monitoring of the paraquat concentration on the prognosis of patients with acute paraquat poisoning. Methods This prospective observational study involved patients with acute paraquat poisoning admitted from March 2012 to September 2015. The patients received either goal-oriented or routine HP. All other treatments were the same between the two groups. The primary endpoint was 28-day mortality after poisoning. The secondary endpoints were the incidence of organ dysfunction within 7 days and 7-day mortality...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29081107/-a-case-report-of-acute-severe-paraquat-poisoning-clinical-cure
#8
H L Liu, X D Jian, D X Wang
No abstract text is available yet for this article.
July 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29081105/-experimental-study-scavenging-effect-of-paraquat-by-hemoperfusion
#9
Y H Pei, Y Z He, X G Zhang, B S Sun
Objective: To determine the scavenging effect and the change of metabolism of paraquat (PQ) using hemoperfusion (HP) once and twice within 12 hours after intoxication and explore the better scheme of HP. Methods: 18 beagles were randomly divided into 3 groups. Single HP group, Double HP group and Control group. Peripheral veins blood was collected at different times within 48 hours after exposure in each group. Toxin concentration was measured, analyzed and compared among 3 groups. Results: 6 hours after exposure, Single HP group and Double HP group has finished the first HP treatment, and the concentration of PQ was lower than that of the control group, the difference was statistically significant (P<0...
July 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29049326/a-new-machine-learning-method-to-prognosticate-paraquat-poisoned-patients-by-combining-coagulation-liver-and-kidney-indices
#10
Lufeng Hu, Huaizhong Li, Zhennao Cai, Feiyan Lin, Guangliang Hong, Huiling Chen, Zhongqiu Lu
The prognosis of paraquat (PQ) poisoning is highly correlated to plasma PQ concentration, which has been identified as the most important index in PQ poisoning. This study investigated the predictive value of coagulation, liver, and kidney indices in prognosticating PQ-poisoning patients, when aligned with plasma PQ concentrations. Coagulation, liver, and kidney indices were first analyzed by variance analysis, receiver operating characteristic curves, and Fisher discriminant analysis. Then, a new, intelligent, machine learning-based system was established to effectively provide prognostic analysis of PQ-poisoning patients based on a combination of the aforementioned indices...
2017: PloS One
https://www.readbyqxmd.com/read/29026307/porous-se-sio2-nanospheres-treated-paraquat-induced-acute-lung-injury-by-resisting-oxidative-stress
#11
Yong Zhu, Guoying Deng, Anqi Ji, Jiayi Yao, Xiaoxiao Meng, Jinfeng Wang, Qian Wang, Qiugen Wang, Ruilan Wang
Acute paraquat (PQ) poisoning is one of the most common forms of pesticide poisoning. Oxidative stress and inflammation are thought to be important mechanisms in PQ-induced acute lung injury (ALI). Selenium (Se) can scavenge intracellular free radicals directly or indirectly. In this study, we investigated whether porous Se@SiO2 nanospheres could alleviate oxidative stress and inflammation in PQ-induced ALI. Male Sprague Dawley rats and RLE-6TN cells were used in this study. Rats were categorized into 3 groups: control (n=6), PQ (n=18), and PQ + Se@SiO2 (n=18)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28978283/tissue-metabolic-changes-for-effects-of-pirfenidone-in-rats-of-acute-paraquat-poisoning-by-gc-ms
#12
Jianshe Ma, Fa Sun, Bingbao Chen, Xiaoting Tu, Xiufa Peng, Congcong Wen, Lufeng Hu, Xianqin Wang
We developed a metabolomic method to evaluate the effect of pirfenidone on rats with acute paraquat (PQ) poisoning, through the analysis of various tissues (lung, liver, kidney, and heart), by gas chromatography-mass spectrometry (GC-MS). Thirty-eight rats were randomly divided into a control group, an acute PQ (20 mg kg(-1)) poisoning group, a pirfenidone (20 mg kg(-1)) treatment group, and a pirfenidone (40 mg kg(-1)) treatment group. Partial least squares-discriminate analysis (PLS-DA) revealed metabolic alterations in rat tissue samples from the two pirfenidone treatment groups after acute PQ poisoning...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28972357/-investigation-paraquat-poisoning-in-southwest-of-iran-from-sign-to-mortality-and-morbidity
#13
Farkhonde Jamshidi, Glareh Fathi, Hannaneh Davoodzadeh
Introduction: Paraquat is the most important herbicide of bi-prides class which is used widely in agriculture part but in many countries such as Iran, this herbicide use for suicide. This study was conducted with the aim to investigating Paraquat poisoning in Khuzestan province of Iran. Material and methods: This study is a retrospective and statistic investigation in which 159 files of toxicity cases were investigated during 2004 to 2015. The patients were contacted to inquire into their health, after completing a questionnaire, the data was gathered and analyzed using SPSS software...
2017: Archiwum Medycyny Sa̧dowej i Kryminologii
https://www.readbyqxmd.com/read/28936961/-effects-of-small-rna-interference-targeting-mammalian-target-of-rapamycin-on-paraquat-induced-pulmonary-fibrosis-in-rats
#14
Wenbin Yang, Xiaoqing Zhao, Ran Liang, Da Chen
OBJECTIVE: To investigate the effects of small RNA interference targeting mammalian target of rapamycin (mTOR) expression on paraquat-induced pulmonary fibrosis in rats. METHODS: Human embryonic kidney cells HEK-293 were cultured in vitro. The mTOR small interfering RNA (mTOR-siRNA) expression plasmid transfection lentivirus was constructed, and non-specific sequence plasmid with no homology to mTOR gene was set as the control. Seventy-two healthy male Sprague-Dawley (SD) rats were randomly divided into normal saline (NS) control group, paraquat model group, mTOR unrelated sequence group, and mTOR-siRNA group, with 18 rats in each group...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28881652/predictors-of-acute-kidney-injury-after-paraquat-intoxication
#15
Cheng-Hao Weng, Hui-Hsiang Chen, Ching-Chih Hu, Wen-Hung Huang, Ching-Wei Hsu, Jen-Fen Fu, Wey-Ran Lin, I-Kwan Wang, Tzung-Hai Yen
Paraquat intoxication is characterized by multi-organ failure, causing substantial mortality and morbidity. Many paraquat patients experience acute kidney injury (AKI), sometimes requiring hemodialysis. We observed 222 paraquat-intoxicated patients between 2000 and 2012, and divided them into AKI (n = 103) and non-AKI (n = 119) groups. The mortality rate was higher for AKI than non-AKI patients (70.1% vs. 40.0%, P < 0.001). Patients with AKI had a longer time to hospital arrival (P = 0.003), lower PaO2 (P = 0...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28808421/crosstalk-between-mitochondrial-fission-and-oxidative-stress-in-paraquat-induced-apoptosis-in-mouse-alveolar-type-ii-cells
#16
Guangju Zhao, Kaiqiang Cao, Changqin Xu, Aifang Sun, Wang Lu, Yi Zheng, Haixiao Li, Guangliang Hong, Bing Wu, Qiaomeng Qiu, Zhongqiu Lu
Paraquat (PQ), as a highly effective and nonselective herbicide, induces cell apoptosis through generation of superoxide anions which forms reactive oxygen species (ROS). Mitochondria, as regulators for cellular redox signaling, have been proved to play an important role in PQ-induced cell apoptosis. This study aimed to evaluate whether and how mitochondrial fission interacts with oxidative stress in PQ-induced apoptosis in mouse alveolar type II (AT-II) cells. Firstly, we demonstrated that PQ promoted apoptosis and release of cytochrome-c (Cyt-c)...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28798883/magnetic-solid-phase-extraction-using-fe3o4-sio2-magnetic-nanoparticles-followed-by-uv-vis-spectrometry-for-determination-of-paraquat-in-plasma-and-urine-samples
#17
Ou Sha, Yu Wang, Xin Yin, Xiaobing Chen, Li Chen, Shujun Wang
A rapid and simple method was optimized and validated for the separation and quantification of paraquat, a frequently used herbicide and a leading cause of fatal poisoning worldwide, at trace levels with UV-Vis spectrophotometry in plasma and urine samples by direct magnetic solid-phase extraction. Fe3O4@SiO2 nanoparticles (NPs) were used as the magnetic solid-phase extraction agents and the paraquat absorbed on NPs was eluted using NaOH and ascorbic acid. Upon optimization, paraquat could be extracted and concentrated from various samples by 35-fold...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28780814/-intervention-of-edaravone-against-renal-injury-induced-by-acute-paraquat-poisoning-in-rats
#18
S Zhang, Z X Chen, Y Y Jiang, Q Q Cai, Z H Yang, C R Wang, X Y Wu, P Ying, Z Q Lu
Objective: To investigate the dynamic change of paraquant-induced kidney injury in rats and the protective effect of edaravone. Methods: Eighty SD rats were randomly divided into 4 groups: the normal control group, paraquat poisoning group, edaravone treatment group and edaravone control group. The normal control group of 8 rats were given 1 ml of 0.9% sodium chloride through the abdominal cavity, and the same amount of fluid into the abdominal cavity after 30 minutes. The paraquat poisoning group of 24 rats were given 1 ml of paraquat solution (20 mg/kg) through the abdominal cavity to build poisoning models, and the same amount of 0...
June 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28780796/-changes-of-integrin-linked-kinase-expression-on-rats-pulmonary-fibrosis-induced-by-paraquat
#19
Y W Su, Y H Li, F Li, Y C Feng, H Huang, B X Wei, Y M Liu
Objective: To observe the expression of integrin-linked kinase on pulmonary fibrosis of paraquat (PQ) poisoning rats, and to discuss the relationship between ILK with pulmonary fibrosis induced by paraquat. Methods: Forty male Sprague-Dawley (SD) rats were randomly divided into control group and paraquat group, 20 in each group; the PQ group rats were intraperitoneally injected PQ liquid (18 mg/kg) , and the control group rats were injected the same volume of saline; 5 rats of these two groups were respectively sacrificed after 7, 14, 28, 56 days of PQ injection; according to the results of lung biopsy HE staining and Masson staining to observe the lung pathologic changes, measure the value of lung hydroxyproline and the expression of ILK...
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28780789/-the-study-of-using-salvianolate-treat-acute-lung-injury-in-rats-induced-by-paraquat
#20
Z W Wang, X X Li, X D Jian, Z C Zhang, B T Kan
Objective: To establish to paraquat poisoning acute lung injury animal model to study the therapeutic effect of Salvia polyphenols acid salt of paraquat-induced acute lung injury. Methods: Adult male Wister rats 120, were randomly divided into three groups: the paraquat exposure group, the start of the experiment to give a one-time 20% paraquat dope orally 50 mg/kg body weight of rats; salvianolate treatment group, the start of the experiment paraquat to give a one-time 20% the stock solution orally 50 mg/kg body weight of rats, and then given daily intraperitoneal injection of 200 mg/kg body weight of rats salvianolate; blank control group was given the same amount normal saline...
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
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