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Paraquat poisoning

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https://www.readbyqxmd.com/read/28424456/paraquat-poisoning-induced-pulmonary-epithelial-mesenchymal-transition-through-notch1-pathway
#1
Tiegang Li, Xiangming Yang, Shiyu Xin, Yan Cao, Nana Wang
Progressive pulmonary fibrosis is the most characteristic feature of subacute PQ poisoning. Epithelial-to-mesenchymal transition (EMT) is reported to be involved in the pulmonary fibrosis after PQ exposure. Recent evidence suggested Notch signaling is required for EMT. In this study, we investigated whether Notch1 and TGF-β1/Smad3 signaling was involved in EMT caused by PQ. It is demonstrated that A549 cells underwent EMT after treated with PQ at dose of 300 μmol/L for 6 days, charactered by increasing expression of mesenchymal marker α-SMA and decreasing expression of epithelial marker E-cadherin...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28384906/golden-hours-in-severe-paraquat-poisoning-the-role-of-early-haemoperfusion-therapy
#2
Raghavendra Rao, Rama Bhat, Swathi Pathadka, Sravan Kumar Chenji, Savio Dsouza
INTRODUCTION: Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for paraquat poison and consumption is often fatal. The usual cause of death is either acute lung injury or multi-organ failure. AIM: To evaluate the role of early haemoperfusion as a therapy in paraquat poisoned patients. MATERIALS AND METHODS: This study was a retrospective analysis of patients admitted to a Tertiary Medical College Hospital between January 2012 and December 2015 with history of paraquat consumption, comparing outcomes in those who received only gastric lavage and symptomatic treatment with those who received haemoperfusion as a therapy...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28377603/hmgb1-tlr4-il23-il17a-axis-promotes-paraquat-induced-acute-lung-injury-by-mediating-neutrophil-infiltration-in-mice
#3
Bailing Yan, Feng Chen, Lijun Xu, Jihong Xing, Xuefu Wang
Paraquat is a poisoning herbicide that primarily targets lung, leading to severe acute lung injury characterized by extensive neutrophil infiltration. However, the mechanisms underlying the neutrophil infiltration is not clear. In this study, we demonstrated the significance of the signaling cascade from high-mobility group box 1 (HMGB1), to Toll-like receptor 4 (TLR4), interleukin-23 (IL-23), and lastly to IL-17A during the paraquat-induced neutrophil infiltration and the subsequent lung injury in mice. Paraquat challenge significantly elevated serum levels of IL-17A and IL-23, the percentage of IL-17A-producing γδT cells in the lung, and the level of HMGB1 in bronchoalveolar lavage fluid...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28372541/nephrotoxicity-induced-proteinuria-increases-biomarker-diagnostic-thresholds-in-acute-kidney-injury
#4
Fahim Mohamed, Nicholas A Buckley, John W Pickering, Klintean Wunnapuk, Sandamali Dissanayake, Umesh Chathuranga, Indika Gawarammana, Shaluka Jayamanne, Zoltan H Endre
BACKGROUND: Paraquat ingestion is frequently fatal. While biomarkers of kidney damage increase during paraquat-induced acute kidney injury (AKI), significant concurrent proteinuria may alter diagnostic thresholds for diagnosis and prognosis to an unknown extent. This study evaluated the effect of albuminuria on biomarker cutoffs for diagnosis and outcome prediction. METHODS: This was a multi-centre prospective clinical study of patients following acute paraquat self-poisoning in 5 Sri Lankan hospitals...
April 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28352307/mumps-caused-by-paraquat-induced-poisoning-a-case-report
#5
Xiaoyan Xu, Zhongkai Yu, Yongguang Liang, Hengqiang Gao, Yilin Liu, Yunbei Yu
Paraquat (PQ) is a highly toxic herbicide that harms the liver, kidney, lungs and heart, and results in a variety of complications. The majority of patients with severe PQ poisoning may succumb to multiple organ failure, and the mortality rate is high. Although a large number of studies have been performed investigating PQ poisoning, cases of mumps caused by PQ-induced poisoning are rare. In the present case report, a 45-year-old female who ingested PQ was admitted to the Emergency Department of Liaocheng People's Hospital (Liaocheng, China)...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28261553/discernment-scheme-for-paraquat-poisoning-a-five-year-experience-in-shiraz-iran
#6
Saeed Kavousi-Gharbi, Reza Jalli, Akbar Rasekhi-Kazerouni, Zahra Habibagahi, Sayed Mahdi Marashi
AIM: To evaluate various schemes for paraquat poisoning and different variables that influence the outcome of acute paraquat poisoning. METHODS: In a cross-sectional study, the information about all cases of acute paraquat poisoning who were admitted to teaching hospitals affiliated to Shiraz University of Medical Sciences, in a five year period (September 2010 to September 2015) were evaluated. The variables included: Demographic data, medical assessment, therapeutic options, laboratory findings, and the outcomes...
February 20, 2017: World Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28249220/chloroquine-attenuates-paraquat-induced-lung-injury-in-mice-by-altering-inflammation-oxidative-stress-and-fibrosis
#7
Haitao Shen, Na Wu, Yu Wang, Hongyu Zhao, Lichun Zhang, Tiegang Li, Min Zhao
Paraquat is one of the most extensively used herbicides and has high toxicity for humans and animals. However, there is no effective treatment for paraquat poisoning. The aim of the present study was to evaluate the effects of chloroquine on paraquat-induced lung injury in mice. Mice received a single intraperitoneal injection of paraquat and a daily intraperitoneal injection of the indicated dosages of chloroquine or dexamethasone. The histological changes, inflammation and oxidative stress in the lungs were examined at day 3, and the degree of pulmonary fibrosis was examined at day 28...
February 25, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28241698/-value-of-base-excess-in-predicting-the-prognosis-of-patients-with-paraquat-poisoning
#8
X W Kang, H Tong, K Q Cao, Q F Mo, L W Li, G L Hong, L Mo, D Li, G J Zhao, Z Q Lu
Objective: To explore prognostic factors of acute paraquat poisoning (APP) , analyze the correlation between base excess (BE) and plasma concentration of paraquat (C-PQ) and discuss BE level in evalua-tion of prognosis of acute paraquat poisoning patients. Methods: We retrospectively selected 84 APP patients who admitted to Emergency Intensive Care Unit (EICU) of our hospital from 2009.9.1 to 2015.8.31.Clinical data from 84 APP patients were analyzed. BE、C-PQ、time of gastric lavagesince ingestion、time of hemoperfusion since ingestion、severity index of paraquat poisoning (SIPP) 、white blood cell (WBC) 、percentage of neutrophils (N%) 、hemoglobin (HB) 、creatinine (Cr) 、alanine aminotransferase (ALT) 、aspartate aminotransferase (AST) 、partial pressure of oxygen (PaO(2)) 、partial pressure of carbon dioxide (PaCO(2)) and other laboratory parameters were measured...
January 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28131803/myd88-gene-knockout-attenuates-paraquat-induced-acute-lung-injury
#9
Haitao Shen, Na Wu, Yu Wang, Feng Guo, Lianghong Chen, Zhigang Zhang, Dong Jia, Min Zhao
OBJECTIVE: This study investigated the role of myeloid differentiation factor 88 (MyD88) in paraquat-induced acute lung injury (ALI). METHODS: C57BL mice were divided into the control group, paraquat group, MyD88 knockout (KO) group, and MyD88 KO plus paraquat group. At 48h after paraquat poisoning, serum and lung tissues were collected. ELISA was employed to detect tumor necrosis factor-α (TNF-α) and interleukine-1β (IL-1β) contents in serum. Lung tissues were processed for hematoxylin-eosin staining, followed by histological scoring...
March 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28123623/intravenous-injection-of-xuebijing-attenuates-acute-kidney-injury-in-rats-with-paraquat-intoxication
#10
Jia-Jun Xu, Jian-Tao Zhen, Li Tang, Qing-Ming Lin
BACKGROUND: The study aimed to investigate the therapeutic benefits of intravenous Xuebijing on acute kidney injury (AKI) in rats with paraquat intoxication. METHODS: Male Sprague-Dawley rats were randomly divided equally into three groups: sham group (n=8), paraquat group (n=8) and Xuebijing-treated group (n=8) using a random number table. The rats were intraperitoneally injected with 50 mg/kg of paraquat. One hour after paraquat administration, the rats were treated intravenously with Xuebijing (8 mL/kg)...
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28070046/-dose-effect-relationship-between-vitamin-c-and%C3%A2-paraquat-poisoning-rats
#11
Baoling Wen, Lei Yu, Yan Fang, Xiaolong Wang
To explore the dose-effect relationship between vitamin C and paraquat (PQ) poisoning rats.
 Methods: A total of 40 Sprague-Dawley (SD) rats were randomly divided into 4 groups: a control group, a PQ poisoning group, a vitamin C group 1 and a vitamin C group 2 (n=10 in each group). 150 mg/kg PQ was perfused into rat stomach to establish PQ poisoning rat model. In PQ poisoning group, 30 mg/kg methylprednisolone and 2.5 mg/kg cyclophosphamide were injected peritoneally on the basis of PQ poisoning rat model...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27884773/an-intelligent-prognostic-system-for-analyzing-patients-with-paraquat-poisoning-using-arterial-blood-gas-indexes
#12
Lufeng Hu, Feiyan Lin, Huaizhong Li, Changfei Tong, Zhifang Pan, Jun Li, Huiling Chen
The arterial blood gas (ABG) test is used to assess gas exchange in the lung, and the acid-base level in the blood. However, it is still unclear whether or not ABG test indexes correlate with paraquat (PQ) poisoning. This study investigates the predictive value of ABG tests in prognosing patients with PQ poisoning; it also identifies the most significant indexes of the ABG test. An intelligent machine learning-based system was established to effectively give prognostic analysis of patients with PQ poisoning based on ABG indexes...
November 21, 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27883937/atorvastatin-protected-from-paraquat-induced-cytotoxicity-in-alveolar-macrophages-via-down-regulation-of-tlr-4
#13
Nazli Alizadeh-Tabrizi, Hassan Malekinejad, Soheil Varasteh, Hadi Cheraghi
The current study designed to clarify the mechanism of paraquat-induced cytotoxicity and protective effects of Atorvastatin on freshly isolated alveolar macrophages (AMs). AMs were collected via bronchoalveolar lavage and exposed to various concentrations of paraquat in the presence and absence of atorvastatin for 24h. Cell viability, myeloperoxidase activity; nitric oxide generation and total antioxidant capacity were assessed. Expression of TLR-4 at mRNA and protein levels were studied by using PCR and western blot methods Atorvastatin enhanced the paraquat-reduced cell viability and reduced the paraquat-induced myeloperoxidase activity and nitric oxide production...
January 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27866563/-recent-advance-of-cytokines-in-the-pathogenesis-of-lung-injury-induced-by-paraquat-poisoning
#14
W Y Fang, X S Xie, S G Feng
No abstract text is available yet for this article.
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27866555/-two-cases-of-acute-poisoning-of-paraquat-with-dursban-and-paraquat-with-bromadiolone
#15
H B Zhou, M Xia
No abstract text is available yet for this article.
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27866548/-effect-of-heme-oxygenase-1-transduced-by-cell-penetrating-peptide-pep-1-on-renal-injury-in-rats-with-acute-paraquat-poisoning
#16
X Wang, Y X Zhao, H X Li, A J Li, S Liu, H M Chen, W Z Cui
Objective: To study the effects of heme oxygenase-1 transduced by cell penetrating peptide PEP-1 on renal injury in acute paraquat-induced rats. Methods: The fusion protein PEP-1/HO-1 was manufactured by genetic engineering methods. One hundred and twenty-six healthy adult Sprague-Dawley (SD) rats (63 male, 63 female) were randomly divided into three groups: (1) Control group: 42 rats, (2) Poisoned group: 42 rats, (3) PEP-1/HO-1 intervention group: 42 rats. The rats in Poisoned group and intervention group were treated intraperitoneally with paraquat (25 mg/kg) deliquated with normal saline...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27824090/prognostic-value-of-hematological-parameters-in-patients-with-paraquat-poisoning
#17
Deng-Chuan Zhou, Hong Zhang, Zhi-Ming Luo, Qi-Xing Zhu, Cheng-Fan Zhou
Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 2010 to December 2015 at the First Affiliated Hospital, Anhui Medical University (Hefei, China). A total of 202 patients were included in the study, and the 30-day mortality was 51.98%. Leukocyte, neutrophil counts and neutrophil-lymphocyte ratio (NLR) were significantly higher in non-survivors than in survivors...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27728610/clinical-profile-of-paraquat-poisonings
#18
K Prabhath Kiran Reddy, Manthappa M
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728609/comparision-of-clinical-outcome-of-paraquat-poisoning-in-patients-treated-with-and-without-methylprednisolone
#19
Harikrishna A, Chandrashekar V, Gururaj N, Srilatha
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728607/fanconi-syndrome-in-paraquat-poisoning
#20
Narendran Krishnamoorthi, Christopher C Pais, Muralidhara Yadiyal B, Pradeep Kumar Shenoy, Riffat Abdulaziz
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
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