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Paraquat poisoning

Sa'ed H Zyoud
BACKGROUND: Paraquat is considered to be the main pesticide involved in accidental and intentional poisoning, and is responsible for a high rate of morbidity and mortality. The aim of this study is to present a comprehensive bibliometric analysis of paraquat intoxication-related research. METHODS: Data was retrieved in March 2017 from the Scopus database. An overview of the research on paraquat intoxication was presented alongside the information related to several bibliometric indicators, such as research trends, countries with their h-index, collaboration, hot issues, top-cited publications, journals, and institutions...
March 14, 2018: American Journal of Industrial Medicine
Yin-Hui Leong, Adilah Mohamed Ariff, Halilol Rahman Mohamed Khan, Noor Afiza Abdul Rani, Mohamed Isa Abdul Majid
This study analyses the incidences and patterns of paraquat poisoning from calls received at the Malaysia National Poison Centre (NPC) since 2004 following the ban of the herbicide (2004-2006) and subsequent restriction up to year 2015. Related reported cases to the centre over twelve years (2004-2015) were retrieved and studied in respect to socio-demographic characteristics, mode and type of poisonings, exposure routes and location of incident. Ages of poisoned victims range from 10 months old to 98 years with males being intoxicated more frequently than females (ratio male to female = 2...
March 6, 2018: Journal of Forensic and Legal Medicine
Junbo Zhu, Yongtao Yu, Hongbo Li, Fenshuang Zheng, Ruyun Lin, Chun'ai Yang
OBJECTIVE: To explore the effect of sucralfate on cytokines in rats with paraquat (PQ) poisoning. METHODS: Seventy-two healthy male Sprague-Dawley (SD) rats were randomly divided into PQ model group, sodium bicarbonate intervention group (SB group) and sucralfate suspension gel group (LTL group), with 24 rats in each group. The rat model of PQ poisoning was reproduced by one-time intragastric administration of PQ solution 25 mg/kg. The rats in SB group and LTL group were intragastricly administrated with 5 mL×kg-1 ×d-1 of 100 g/L sodium bicarbonate or 200 g/L sucralfate at 2 hours after exposing to PQ, and the rats in PQ model group were given the same amount of sterile saline...
March 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Xiuxian Wan, Chunyu Zhou, Xin Kang, Dayong Hu, Wen Xue, Xinhua Li, Hui Bao, Ai Peng
BACKGROUND Paraquat is a major cause of fatal poisoning after ingestion in many parts of Asia and the Pacific nations. However, optimal prognostic indicators to evaluate patient mortality have not been unequivocally established. Following acute paraquat poisoning, a number of amino acids (AA), are abnormally expressed in metabolic pathways. However, the alterations in AA metabolite levels after paraquat poisoning remain unknown in humans. MATERIAL AND METHODS In the present study, 40 patients were enrolled, of whom 16 survived and 24 died...
March 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
L J Yu, X D Jian, Z C Zhang, Y L Ren, Q Ning, K Wang, B J Gao, J E Jia
Objective: To investigate the causes of peripheral vascular thrombosis in patients with paraquat poisoning. Methods: The patients with paraquat poisoning who were admitted to our department in recent two years were observed to screen out the patients with large vessel thrombosis. The data on toxic exposure history, clinical features, and treatment were collected to analyze the causes of thrombosis in the patients with paraquat poisoning. Results: Three patients had typical lower limb thrombosis. There was one case of right common femoral vein thrombosis, one case of bilateral calf muscle vein thrombosis, and one case of right calf superficial vein thrombosis and right calf muscle vein thrombosis...
January 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
X H Li, P B Leng, G C Mao, A H Wang
Objective: To analyze the characteristics of acute pesticide poisoning in Ningbo, and to provide scientific basis for the prevention and control strategy. Methods: In February 2017, the pesticide poisoning report card of Ningbo from 2011 to 2016 was drawn from the China Disease Control and prevention information system. The data of the report card was organized by Excel and analyzed by SPSS19.0 software. Results: 2593 cases of acute pesticide poisoning were reported in Ningbo from 2011 to 2016, 125 deaths, and the case fatality rate was 4...
January 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
W Y Fang, C W Lin, B F Wang, S G Feng
Objective: Construct a paraquat (PQ) cell fibrosis model in vitro, observe the effect of PQ on the expression of a disintegrin and metalloproteinase-17 (ADAM17) in A549 cells, and explore the role of ADAM17 in the pulmonary fibrosis induced by PQ poisoning. Methods: A549 cells are divided into normal control group, different concentration of PQ groups, CCK-8 is used to detect cell viability, screening concentration and time of PQ, cell morphology is observed under microscope; Enzyme-linked immunosorbent assay (ELISA) detectes fibrosis markers of collagen type I (Col I) and fibronectin (FN) expression...
January 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
J Zhang, K X Liu, W Gao, X S Xie
Objective: To establish a rat model of paraquat (PQ) -induced pulmonary fibrosis and observe the changes in thrombospondin-1 (TSP-1) and its receptor CD47 in lung tissue, and to investigate their roles in the pathogenesis of PQ-induced pulmonary fibrosis. Methods: Fifty-four clean adult male Sprague-Dawley rats were randomly divided into normal control group ( n =6) and 2 h, 12 h, 1 d, 3 d, 7 d, and 14 d PQ poisoning groups ( n =8 per group). A rat model of PQ poisoning was established by a single gavage of 20 wt...
December 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
Jian Lu, Yongbing Qian, Wei Jin, Rui Tian, Yong Zhu, Jinfeng Wang, Xiaoxiao Meng, Ruilan Wang
Pulmonary fibrosis (PF) is one of the most prevalent causes of death following paraquat (PQ) poisoning. As demonstrated in previous studies by the present authors, epithelial-to-mesenchymal transition (EMT) is associated with PQ-induced PF. In addition, hypoxia-inducible factor-1α (HIF-1α) and lysyl oxidase (LOX) promote EMT following PQ poisoning. However, the association between HIF-1α- and LOX-mediated regulation of EMT remains unclear. The present study investigated the association between HIF-1α and LOX with regard to PQ-induced EMT...
March 2018: Experimental and Therapeutic Medicine
Liang Sun, Peng-Bo Yan, Yin Zhang, Lu-Qing Wei, Guo-Qiang Li
The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results indicated that 7 patients died and 12 survived. Non-oliguric renal failure occurred in all of the 7 patients who died. Among the 12 surviving patients, 10 had normal renal function and 2 developed non-oliguric renal failure. There was a linear correlation between plasma and urine paraquat concentration prior to and during activated charcoal hemoperfusion...
March 2018: Experimental and Therapeutic Medicine
M Asisha Janeela, Ajoy Oommen, Ajay Kumar Misra, I Ramya
N, N'-dimethyl-4, 4'-bipyridinium dichloride (paraquat) is a widely used synthetic, nonselective contact herbicide. Ingestion of toxic doses of paraquat can be fatal with life-threatening effects on the lungs, gastrointestinal (GI) tract, kidney, liver, heart, and other organs. Till date, there are no specific antidotes and none of the current treatments have proven efficacious. The prognosis is uniformly poor worldwide, including those who treat aggressively with multimodal therapies. Long-term survivors are few, and have GI and pulmonary complications...
July 2017: Journal of Family Medicine and Primary Care
Yuan-Qiang Lu
Though the cases of HIV patients with paraquat (PQ) poisoning are rare, we still found the common features. These recovered HIV patients tended to result in much less lung injury, and had low CD4+ T lymphocyte levels due to HIV infection, which meant they were under the immunosuppressive condition during treatment. This may be conducive to relieve the acute inflammation and lung fibrosis induced by PQ. Thus, we consider the immunosuppressive therapy for PQ poisoning to be appropriate. However, the drugs used currently may be not optimal for toxic patient...
2018: Journal of Zhejiang University. Science. B
Xia Yang, Jing-Hong Zhang, Jian-Feng Zhang, Hua Lin, Wei Chen, Li Xiang, Chao-Qian Li
Recent studies suggest that imbalances in the ratios of CD4+ T helper cell subsets, T helper-17 (Th17) and regulatory T (Treg) cells play a crucial role in the pathogenesis of acute lung injury (ALI). However, studies of the imbalance of Th17/Treg in paraquat (PQ)-induced ALI have not been reported. Therefore, we investigated whether the ratio of Th17/Treg cells in a mouse model of PQ-induced ALI contributes to pathogenesis of ALI. Male Kunming mice were randomly treated with saline (control group) or PQ (PQ-poisoned (PQP) group); mice were sacrificed at either 12 hours (PQP-12h) or 24 hours (PQP-24h and control) post-treatment...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
(no author information available yet)
No abstract text is available yet for this article.
September 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
(no author information available yet)
No abstract text is available yet for this article.
September 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
Hasan Afarnegan, Ali Shahraki, Jafar Shahraki
Paraquat is extensively used as a strong nitrogen-based herbicide for controlling weeds in agriculture. This herbicide is extremely toxic to humans and induces multiorgan failure due to accumulation in the cells. So far, many instances of fatal poisoning have been reported. Paraquat is metabolized primarily in the liver. Accordingly, the effects of aquatic Levisticum officinale extract on biochemical factors and oxidative status were evaluated in hepatocytes exposed to paraquat in this study. The results showed that paraquat-induced hepatocyte destruction is mediated by reactive oxygen species (ROS) production...
November 2017: Pakistan Journal of Pharmaceutical Sciences
Baisheng Sun, Yuezhong He
Paraquat (PQ) as a kind of sterile and herbicides, has effects of contact-kill and systemic action, which can be absorbed quickly by green plants and make them wither and die. Therefore, it is widely used in the agricultural production and occupies a large part in our country's pesticide market. PQ poisoning has become one of the most common pesticide poisoning in our country. PQ can be passivated when combining with soil, but it has great toxicity for human. There are still no specific antidotes for PQ poisoning at home and abroad, and the death rate of PQ oral poisoning is up to 95%...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Tao Liu, Yuan Xie, Mengtong Xu, Fenshuang Zheng
OBJECTIVE: To investigate the protective effect of thalidomide on acute lung injury (ALI) induced by paraquat (PQ) poisoning in rats and its possible mechanism. METHODS: Sixty SPF Wistar rats were randomly divided into six groups with 10 rats in each group. The rat model of PQ poisoning was reproduced by intraperitoneal injection of PQ solution 20 mg/kg (PQ model group), and the rats were treated by intraperitoneal injection of gradient thalidomide (50, 100, 200 mg/kg treatment groups) 30 minutes later continuously for 3 days...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Honggang Chen, Rongjia Yang, Yan Tang, Jun Xu, Youfan Feng, Shijie Liu, Shikui Zhang, Lijun Hou
OBJECTIVE: To observe the effects of curcumin on pulmonary fibrosis and functions on paraquat (PQ)-challenged rats, and investigate the possible mechanism. METHODS: 108 SPF Wistar rats were divided into three groups according to random number sheet: normal saline (NS) control group, PQ model group and curcumin-treatment group. The rats in each group were subdivided into three subgroups according to different time points (3, 7, 14 days), with 12 rats in each subgroup...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Weizhan Wang, Jing Li, Baoyue Zhu, Xun Gao, Qingmian Xiao, Hongna Qi, Yanqiao Ye, Yongjian Liu, Yongyan Han, Gongying Ma, Pu Wang
OBJECTIVE: To investigate the clinical effect of paraquat (PQ) detoxification recipe combined with continuous hemoperfusion (HP) in the treatment of patients with acute paraquat poisoning (APP) and clinical significance of soluble CD14 subtype (sCD14-st, Presepsin). METHODS: A prospective randomized controlled trial was conducted. 152 patients with moderate APP admitted to Department of Emergency Medicine of Harrison International Peace Hospital Affiliated to Hebei Medical University from July 2013 to June 2017 were enrolled, and they were randomly divided into three groups...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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