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https://www.readbyqxmd.com/read/29887391/deep-circumferential-annuloplasty-as-an-adjunct-to-repair-regurgitant-bicuspid-aortic-valves-with-a-dilated-annulus
#1
Omar Nawaytou, Stefano Mastrobuoni, Laurent de Kerchove, Jerome Baert, Munir Boodhwani, Gebrine El Khoury
BACKGROUND: Failure to address the functional aortic annulus during bicuspid aortic valve (BAV) repair has led to early repair failures. The pathology of regurgitant BAV involves annular dilatation, which is more pronounced anteriorly and deep toward the muscular interventricular septum. In this study, we assessed the results of BAV repair using a strategy of deep circumferential annular support involving the septum in patients with a dilated annulus (>26 mm) and moderate to severe aortic regurgitation (AR)...
April 4, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29884493/aortic-root-dynamism-geometry-and-function-after-the-remodeling-operation-clinical-relevance
#2
Magdi H Yacoub, Heba Aguib, Mazen Abou Gamrah, Nairouz Shehata, Mohamed Nagy, Mohamed Donia, Yasmine Aguib, Hesham Saad, Soha Romeih, Ryo Torii, Ahmed Afifi, Su-Lin Lee
OBJECTIVES: Valve-conserving operations for aneurysms of the ascending aorta and root offer many advantages, and their use is steadily increasing. Optimizing the results of these operations depends on providing the best conditions for normal function and durability of the new root. METHODS: Multimodality imaging including 2-dimensional echocardiography, multislice computed tomography, and cardiovascular magnetic resonance combined with image processing and computational fluid dynamics were used to define geometry, dynamism and aortic root function, before and after the remodeling operation...
April 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29861200/autologous-bifurcated-carotid-artery-reconstruction-technique-and-2-year-follow-up
#3
Manuela Aspalter, Klaus Linni, Wolfgang Hitzl, Florian Enzmann, Julio Ellacuriaga, Ara Ugurluoglu, Thomas J Hölzenbein
OBJECTIVE/BACKGROUND: Carotid bifurcation resection with subsequent reconstruction is performed infrequently. While internal carotid artery (ICA) revascularisation is regarded as mandatory, the external carotid artery (ECA) is severed in most instances. Indications for and results of an autologous bifurcated carotid artery reconstruction are discussed. METHODS: This was a single centre retrospective analysis of a consecutive series of patients treated at an academic vascular surgery centre...
May 31, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29860942/challenges-in-cerebrospinal-fluid-shunting-in-patients-with-glioblastoma
#4
Bujung Hong, Manolis Polemikos, Hans E Heissler, Christian Hartmann, Makoto Nakamura, Joachim K Krauss
BACKGROUND: Cerebrospinal fluid (CSF) circulation disturbances may occur during the course of disease in patients with glioblastoma. Ventriculoperitoneal shunting has generally been recommended to improve symptoms in glioblastoma patients. Shunt implantation for patients with glioblastoma, however, presents as a complex situation and produces different problems to shunting in other contexts. Information on complications of shunting glioma patients has rarely been the subject of investigation...
June 4, 2018: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29852193/intravitreal-implantable-magnetic-micropump-for-on-demand-vegfr-targeted-drug-delivery
#5
Cong Wang, Seung-Jun Seo, Jin-Seong Kim, Se-Hee Lee, Jae-Kun Jeon, Jae-Woo Kim, Ki-Hong Kim, Jong-Ki Kim, Jungyul Park
In this paper, we propose an intravitreal implantable magnetic micropump integrated with micro check valve capable of on-demand vascular endothelial growth factor receptor (VEGFR)-targeted drug delivery for the treatment of age-related macular degeneration, diabetic retinopathy and other eye pathologies characterized by ocular neoangiogenesis. Precise on-demand drug release is realized by the deflection of the magnetic membrane assembly according to the external magnetic field, and the membrane assembly consists of a thin elastic polydimethylsiloxane (PDMS) membrane and a cylindrical magnetic nanoparticle-PDMS composite block...
May 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29843425/functional-role-of-non-coding-rnas-during-epithelial-to-mesenchymal-transition
#6
REVIEW
Almudena Expósito-Villén, Amelia E Aránega, Diego Franco
Epithelial-to-mesenchymal transition (EMT) is a key biological process involved in a multitude of developmental and pathological events. It is characterized by the progressive loss of cell-to-cell contacts and actin cytoskeletal rearrangements, leading to filopodia formation and the progressive up-regulation of a mesenchymal gene expression pattern enabling cell migration. Epithelial-to-mesenchymal transition is already observed in early embryonic stages such as gastrulation, when the epiblast undergoes an EMT process and therefore leads to the formation of the third embryonic layer, the mesoderm...
May 28, 2018: Non-Coding RNA
https://www.readbyqxmd.com/read/29804662/tricuspid-valvular-dynamics-and-3-dimensional-geometry-in-awake-and-anesthetized-sheep
#7
Tomasz Jazwiec, Marcin Malinowski, Alastair G Proudfoot, Lenora Eberhart, David Langholz, Hans Schubert, Jeremy Wodarek, Tomasz A Timek
OBJECTIVES: Clinical and experimental tricuspid valve physiology data are derived predominantly from anesthetized subjects, but normal tricuspid valve geometry and dynamics may be altered by general anesthesia and mechanical ventilation. We set out to investigate 3-dimensional geometry and dynamics of the tricuspid valve complex in awake and anesthetized sheep. METHODS: While on cardiopulmonary bypass and with the heart beating, 6 adult sheep (50 ± 8 kg) underwent implantation of 6 sonomicrometry crystals around the tricuspid annulus...
April 21, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29790206/efficacy-and-safety-of-transcatheter-valve-in-valve-replacement-for-mitroflow-bioprosthetic-valve-dysfunction
#8
Victor X Mosquera, Miguel González-Barbeito, Alberto Bouzas-Mosquera, José M Herrera-Noreña, Carlos Velasco, Jorge Salgado-Fernández, Ramón Calviño-Santos, Nicolás Vázquez-González, José M Vázquez-Rodríguez, José J Cuenca-Castillo
OBJECTIVES: Bioprostheses with pericardial leaflets mounted externally on the stent pose a high risk for valve-in-valve (ViV) procedures. This study analyzed the efficacy and safety of ViV procedures for treating structural valve deterioration (SVD) in Mitroflow bioprostheses. METHODS: Between January 2012 and August 2017, 11 patients (mean age 80.3 ± 5.6 years) were treated for SVD of Mitroflow bioprostheses with transcatheter ViV procedures (six transapical [TA] and five transfemoral [TF]) using balloon expandable bioprostheses...
May 22, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29774980/edwards-sapien-xt%C3%A2-pulmonic-valve-compression-after-resuscitation-and-successful-redilatation
#9
Anja Lehner, Marinos Kantzis, Nikolaus A Haas
Despite the increasing use of percutaenous valves, little is known about valve performance after external chest compression. We report a case of a compressed pulmonary Edwards Sapien® XT valve after resuscitation. With the patient on ECMO, successful redilatation was performed with unimpaired postprocedural valve function. We aim to increase the awareness for valve distortion after external chest compression with increasing numbers of transcatheter valvulations. We suggest that immediate re-evaluation of the implanted device via biplane fluoroscopy is mandatory after resuscitation in such cases...
May 18, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29723533/early-degeneration-caused-by-cusp-tear-of-first-generation-trifecta-bioprosthesis
#10
Simone Eichinger, Akmal M A Badreldin, Walter B Eichinger
The Trifecta aortic valve has excellent hemodynamic performance as result of an expansive valve design with a bovine pericardial sheet externally mounted on a titanium stent. We report two cases of early Trifecta valve degeneration, both caused by partial rupture of one of the leaflet cusps three and four years post-implant. Post discharge, both patients had routinely performed echocardiography check-ups, without signs of valve failure. Transesophageal echocardiography performed while emergency hospital readmission due to severe dyspnea revealed transvalvular aortic regurgitation without signs of endocarditis...
April 30, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29710837/mechanism-of-the-dual-activities-of-human-cyp17a1-and-binding-to-anti-prostate-cancer-drug-abiraterone-revealed-by-a-novel-v366m-mutation-causing-17-20-lyase-deficiency
#11
Mónica Fernández-Cancio, Núria Camats, Christa E Flück, Adam Zalewski, Bernhard Dick, Brigitte M Frey, Raquel Monné, Núria Torán, Laura Audí, Amit V Pandey
The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone. In a 46, XY patient with female external genitalia, together with a loss of function mutation S441P, we identified a novel missense mutation V366M at the catalytic center of CYP17A1 which preferentially impaired 17,20 lyase activity. Kinetic experiments with bacterially expressed proteins revealed that V366M mutant enzyme can bind and metabolize pregnenolone to 17OH-pregnenolone, but 17OH-pregnenolone binding and conversion to dehydroepiandrosterone (DHEA) was impaired, explaining the patient’s steroid profile...
April 29, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29706591/semilunar-conchal-cartilage-graft-in-saddle-nose-reconstruction
#12
I Rašić, A Košec, A Pegan
INTRODUCTION: The saddle nose deformity is easily recognized by the loss of septal support and nasal dorsal height with adverse functional and aesthetic consequences. TECHNIQUE: We treated a 50-year-old woman and a 54-year old man that presented with a moderate saddle nose deformity following a previous septorhinoplasty (female patient) and a posttraumatic severe saddle nose deformity (male patient). The patients were treated by open approach rhinoplasty under general anesthesia, and the saddle nose deformity was reconstructed with a semilunar conchal cartilage graft...
April 26, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29687700/impella-pumps-overview-and-access-site-management
#13
Francesco Burzotta, Giulo Russo, Leonardo Previ, Piergiorgio Bruno, Cristina Aurigemma, Carlo Trani
The Impella left ventricular support system consists of two main components: a family of different ventricular support catheters with a microaxial pump to be placed across the aortic valve and a single external controller (AIC) which is connected to activate and control the pump function. Four Impella left ventricular support catheters are available: Impella 2.5, Impella CP, Impella 5.0 and Impella LD. Impella 2.5 and Impella CP are designed for percutaneous peripheral insertion, have respectively a 12F and 14F maximal diameter at the pump level and are capable of providing up to 2...
April 20, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29673851/the-use-of-allogeneic-cartilage-for-grafting-in-functional-and-reconstructive-rhinoplasty
#14
Andrew M Read-Fuller, David M Yates, Alaaaldin Radwan, Alexander M Schrodt, Richard A Finn
PURPOSE: Allogeneic cartilage grafting has multiple uses in rhinoplasty. Autogenous cartilage is frequently used in cases of nasal obstruction or reconstruction, but harvesting grafts can cause complications or might be contraindicated. Rhinoplasties of the patient with cleft might require costochondral grafts. Allogeneic rib is an effective and safe alternative to autogenous grafts, prevents complications, and obviates postoperative admission after rib harvest. MATERIALS AND METHODS: Patients who had allogeneic cartilage placed during functional or reconstructive rhinoplasty were studied from 2 institutions, including 19 who had functional rhinoplasty using allogeneic Cartiform patellar cartilage grafts and 15 patients who underwent reconstructive cleft rhinoplasty with allogeneic rib cartilage...
March 27, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29658049/a-simple-microfluidic-platform-for-rapid-and-efficient-production-of-the-radiotracer-18-f-fallypride
#15
Xin Zhang, Fei Liu, Karla-Anne Knapp, Michael L Nickels, H Charles Manning, Leon M Bellan
Herein, we report the development of a simple, high-throughput and efficient microfluidic system for synthesizing radioactive [18F]fallypride, a PET imaging radiotracer widely used in medical research. The microfluidic chip contains all essential modules required for the synthesis and purification of radioactive fallypride. The radiochemical yield of the tracer is sufficient for multiple animal injections for preclinical imaging studies. To produce the on-chip concentration and purification columns, we employ a simple "trapping" mechanism by inserting rows of square pillars with predefined gaps near the outlet of microchannel...
May 1, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29643124/myocardial-ischaemia-as-a-result-of-external-coronary-compression-from-infective-aortic-root-aneurysm-atypical-presentation-of-prosthetic-valve-endocarditis
#16
Baskar Sekar, Richard Wheeler, Navroz Masani, Sean Gallagher
SummaryThis case describes an unusual presentation of prosthetic valve endocarditis (PVE): an acute coronary syndrome. A 67-year-old male presented with cardiac sounding chest pain on a background of a short history of night sweats, weight loss and general malaise. Four months previously, he had undergone bio-prosthetic aortic valve replacement for severe aortic stenosis and single vessel bypass grafting of the obtuse marginal. Whilst having chest pain, his ECG showed infero-lateral ST depression. Early coronary angiography revealed a new right coronary artery (RCA) lesion that was not present prior to his cardiac surgery...
June 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29589211/a-modified-multi-patch-technique-for-double-layered-repair-of-ischemic-posterior-ventricular-septal-rupture
#17
Takahiro Katsumata, Masahiro Daimon, Hayato Konishi, Shinji Fukuhara
BACKGROUND: The rupture of the posterior ventricular septum after acute inferior myocardial infarction is more challenging to repair than ruptures in other sites since it is less accessible and anatomically restricted. We described a modification of Daggett's original technique of multi-patch repair of ruptured posterior septum. CASE PRESENTATION: The technique was employed in the operation of a 67-year-old male who presented with severe heart failure at the 10th day after he developed inferior myocardial infarction...
March 27, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29576902/maladjustment-of-programmable-ventricular-shunt-valves-by-inadvertent-exposure-to-a-common-hospital-device
#18
R Fujimura, R Lober, K Kamian, L Kleiner
Background: Programmable ventricular shunt valves are commonly used to treat hydrocephalus. They can be adjusted to allow for varying amounts of cerebrospinal fluid (CSF) flow using an external magnetic programming device, and are susceptible to maladjustment from inadvertent exposure to magnetic fields. Case Description: We describe the case of a 3-month-old girl treated for hydrocephalus with a programmable StrataTM II valve found at the incorrect setting on multiple occasions during her hospitalization despite frequent reprogramming and surveillance...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29562424/-safety-and-efficacy-of-transcatheter-aortic-valve-replacement-through-transcarotid-approach-for-patients-with-severe-aortic-valve-stenosis
#19
W Z Pan, D X Zhou, X C Zhang, L Zhang, L Wei, J B Ge
Objective: To investigate the safety and efficacy of transcatheter aortic valve replacement(TAVR) through transcarotid approach for patients with severe aortic valve stenosis. Methods: The clinical data of 9 symptomatic severe aortic valve stenosis patients who had high or prohibitive risk for surgery and not suitable for TAVR through femoral artery access,and thus received TAVR through transcarotid approach in our hospital from November 2015 to February 2017 were retrospectively analyzed.The patients were followed up to observe the safety and efficacy of the procedure...
March 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29534193/modified-ross-konno-procedure-in-children-subcoronary-implantation-technique-with-konno-incision-for-annular-and-subannular-hypoplasia
#20
Peter Murin, Nicodème Sinzobahamvya, Antonia Schulz, Victoria Lorenzen, Stanislav Ovroutski, Felix Berger, Joachim Photiadis, Mi-Young Cho
OBJECTIVES: The technique of subcoronary autograft implantation for the Ross procedure has shown excellent durability of aortic valve function in adults. However, its use in children with hypoplastic aortic annulus or multilevel left ventricular outflow tract obstruction (LVOTO) was traditionally precluded. We combined this technique with a Konno incision and evaluated LVOTO relief and durability of the autograft function in growing patients. METHODS: Between January 2012 and January 2017, 13 patients with severe LVOTO and hypoplastic aortic annulus underwent Ross-Konno procedure with subcoronary autograft implantation...
March 9, 2018: Interactive Cardiovascular and Thoracic Surgery
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