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https://www.readbyqxmd.com/read/27899119/clinical-outcome-and-hemodynamic-behavior-of-the-labcor-dokimos-plus-aortic-valve
#1
Torsten Christ, Konstantin Zhigalov, Wolfgang Konertz, Sebastian Holinski
BACKGROUND: The Labcor Dokimos Plus (LDP) is a stented externally mounted pericardial aortic bioprosthesis, which was recently introduced in Europe. Aims of the study are evaluation of operative and postoperative results as well as hemodynamic performance. METHODS: One hundred consecutive patients with a mean age of 65.9 ± 10.7 years (range 35-87) and a mean EuroSCORE II of 3.1 ± 3.9 (range 0.67-24.5) underwent aortic valve replacement with the LDP. Mean valve-size was 25...
November 29, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27866864/anatomical-histochemical-and-immunohistochemical-characterisation-of-the-cardiac-outflow-tract-of-the-silver-arowana-osteoglossum-bicirrhosum-teleostei-osteoglossiformes
#2
Miguel Lorenzale, Miguel A López-Unzu, M Carmen Fernández, Ana C Durán, Borja Fernández, M Teresa Soto-Navarrete, Valentín Sans-Coma
The cardiac outflow tract of chondrichthyans and actinopterygians is composed of a myocardial conus arteriosus and a non-myocardial bulbus arteriosus. In teleosts, the conus has been subjected to a reduction in size over the evolution in conjunction with the further development of the bulbus. Most studies on the outflow tract of the teleost heart refer to species of modern groups and are mainly devoted to the bulbus. Knowledge on the outflow tract of species belonging to early teleost groups is scarce. The aim here was to characterise the structure of the cardiac outflow tract of the silver arowana, a representative of the ancient teleost clade of the Osteoglossomorpha...
September 28, 2016: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/27866824/detection-of-her2-overexpressing-cancer-cells-using-keyhole-shaped-chamber-array-employing-a-magnetic-droplet-handling-system
#3
Mina Okochi, Shinji Koike, Masayoshi Tanaka, Hiroyuki Honda
An on-chip gene expression analysis compartmentalized in droplets was developed for detection of cancer cells at a single-cell level. The chip consists of a keyhole-shaped reaction chamber with hydrophobic modification employing a magnetic bead-droplet-handling system with a gate for bead separation. Using three kinds of water-based droplets in oil, a droplet with sample cells, a lysis buffer with magnetic beads, and RT-PCR buffer, parallel magnetic manipulation and fusion of droplets were performed using a magnet-handling device containing small external magnet patterns in an array...
November 11, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27847065/an-option-for-concomitant-management-of-moderate-marfan-root-aneurysm-at-the-time-of-mitral-valve-repair-a-role-for-personalized-external-aortic-root-support
#4
Umberto Benedetto, Xu Yu Jin, Elaine Hill, Tom Treasure, Mario Petrou
Two patients had mitral valve repair for severe regurgitation in the presence of a Marfan aortic root aneurysm. Concomitant personalized external aortic root support was used at the same operation to halt aneurysm progression and to correct mild aortic regurgitation.
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27826462/reconstruction-of-alar-nasal-cartilage-defects-using-a-tissue-engineering-technique-based-on-a-combined-use-of-autologous-chondrocyte-micrografts-and-platelet-rich-plasma-preliminary-clinical-and-instrumental-evaluation
#5
Pietro Gentile, Maria G Scioli, Alessandra Bielli, Augusto Orlandi, Valerio Cervelli
BACKGROUND: Developing cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. The combined use of autologous chondrocyte micrografts and platelet-rich plasma (PRP) is an alternative that opens a new era in this field. METHODS: At the Department of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Italy, 11 patients underwent nasal alar reconstruction with chondrocyte micrografts gently poured onto PRP in solid form...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27797384/transient-microfluidic-compartmentalization-using-actionable-microfilaments-for-biochemical-assays-cell-culture-and-organs-on-chip
#6
Ayako Yamada, Renaud Renault, Aleksandra Chikina, Bastien Venzac, Iago Pereiro, Sylvie Coscoy, Marine Verhulsel, Maria Carla Parrini, Catherine Villard, Jean-Louis Viovy, Stéphanie Descroix
We report here a simple yet robust transient compartmentalization system for microfluidic platforms. Cylindrical microfilaments made of commercially available fishing lines are embedded in a microfluidic chamber and employed as removable walls, dividing the chamber into several compartments. These partitions allow tight sealing for hours, and can be removed at any time by longitudinal sliding with minimal hydrodynamic perturbation. This allows the easy implementation of various functions, previously impossible or requiring more complex instrumentation...
October 31, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27788941/long-term-outcomes-of-external-repair-as-a%C3%A2-rescue-operation-for-atrioventricular-groove-disruption
#7
Nikola Dobrilovic, Jaishankar Raman, James G Fingleton, Andrew Maslow, Arun K Singh
BACKGROUND: Atrioventricular groove disruption (AVGD) is an uncommon but lethal complication of mitral valve operations associated with mortality approaching 90%. Traditionally, an "internal" repair is performed requiring prosthesis explantation, complete atrioventricular groove reconstruction using a patch positioned from within the cardiac cavity, and subsequent prosthesis reimplantation. This is a massive undertaking that is usually unsuccessful. We examine the utility of an alternative, "external" approach for rescue of AVGD...
October 24, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27765189/prediction-of-poor-outcome-after-transcatheter-aortic-valve-replacement
#8
Suzanne V Arnold, Jonathan Afilalo, John A Spertus, Yuanyuan Tang, Suzanne J Baron, Philip G Jones, Michael J Reardon, Steven J Yakubov, David H Adams, David J Cohen
BACKGROUND: A series of models have been developed to identify patients at high risk for poor outcomes after transcatheter aortic valve replacement (TAVR) to help guide treatment choices, offer patients realistic expectations of long-term outcomes, and support decision making. OBJECTIVES: This study examined the performance of the previously developed TAVR Poor Outcome risk models in an external dataset and explored the incremental contribution of geriatric domains to model performance...
October 25, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27720172/nonlinear-model-predictive-control-applied-to-the-separation-of-praziquantel-in-simulated-moving-bed-chromatography
#9
A S Andrade Neto, A R Secchi, M B Souza, A G Barreto
An adaptive nonlinear model predictive control of a simulated moving bed unit for the enantioseparation of praziquantel is presented. A first principle model was applied at the proposed purity control scheme. The main concern about this kind of model in a control framework is in regard to the computational effort to solve it; however, a fast enough solution was achieved. In order to evaluate the controller's performance, several cases were simulated, including external pumps and switching valve malfunctions...
September 30, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27713988/magnetic-adhesive-based-valves-for-microfluidic-devices-used-in-low-resource-settings
#10
Jason C Harper, Jenna M Andrews, Candice Ben, Andrew C Hunt, Jaclyn K Murton, Bryan D Carson, George D Bachand, Julie A Lovchik, William D Arndt, Melissa R Finley, Thayne L Edwards
Since the introduction of micro total analytical systems (μTASs), significant advances have been made toward development of lab-on-a-chip platforms capable of performing complex biological assays that can revolutionize public health, among other applications. However, use of these platforms in low-resource environments (e.g. developing countries) has yet to be realized as the majority of technologies used to control microfluidic flow rely on off-device hardware with non-negligible size, cost, power requirements and skill/training to operate...
October 18, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27692768/concept-of-an-expandable-cardiac-valve-for-surgical-implantation-in-infants-and-children
#11
Sitaram M Emani, Breanna L Piekarski, David Zurakowski, Christopher A Baird, Audrey C Marshall, James E Lock, Pedro J Del Nido
BACKGROUND: Options for cardiac valve replacement in children are limited to fixed-diameter prostheses that do not accommodate for somatic growth. An externally stented bovine jugular vein graft has been modified for surgical valve replacement in pediatric patients, with the intention of subsequent valve expansion in the catheterization laboratory as the child grows. METHODS: Pediatric patients at a single institution who underwent surgical implantation of an expandable bovine jugular vein valve between 2010 and 2014 were reviewed retrospectively...
August 31, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27669452/combined-use-of-morphological-and-molecular-tools-to-resolve-species-mis-identifications-in-the-bivalvia-the-case-of-glycymeris-glycymeris-and-g-pilosa
#12
Ariadna Purroy, Tanja Šegvić-Bubić, Anna Holmes, Ivana Bušelić, Julien Thébault, Amy Featherstone, Melita Peharda
Morphological and molecular tools were combined to resolve the misidentification between Glycymeris glycymeris and Glycymeris pilosa from Atlantic and Mediterranean populations. The ambiguous literature on the taxonomic status of these species requires this confirmation as a baseline to studies on their ecology and sclerochronology. We used classical and landmark-based morphometric approaches and performed bivariate and multivariate analyses to test for shell character interactions at the individual and population level...
2016: PloS One
https://www.readbyqxmd.com/read/27665230/antisense-oligonucleotides-targeting-apolipoprotein-a-in-people-with-raised-lipoprotein-a-two-randomised-double-blind-placebo-controlled-dose-ranging-trials
#13
Nicholas J Viney, Julian C van Capelleveen, Richard S Geary, Shuting Xia, Joseph A Tami, Rosie Z Yu, Santica M Marcovina, Steven G Hughes, Mark J Graham, Rosanne M Crooke, Stanley T Crooke, Joseph L Witztum, Erik S Stroes, Sotirios Tsimikas
BACKGROUND: Elevated lipoprotein(a) (Lp[a]) is a highly prevalent (around 20% of people) genetic risk factor for cardiovascular disease and calcific aortic valve stenosis, but no approved specific therapy exists to substantially lower Lp(a) concentrations. We aimed to assess the efficacy, safety, and tolerability of two unique antisense oligonucleotides designed to lower Lp(a) concentrations. METHODS: We did two randomised, double-blind, placebo-controlled trials...
November 5, 2016: Lancet
https://www.readbyqxmd.com/read/27648730/electrostatic-charge-and-electric-field-induced-smart-gating-for-water-transportation
#14
Kai Xiao, Yahong Zhou, Xiang-Yu Kong, Ganhua Xie, Pei Li, Zhen Zhang, Liping Wen, Lei Jiang
Regulating and controlling the transport of water across nanochannels is of great importance in both fundamental research and practical applications, because it is difficult to externally control water flow through nanochannels as in biological channels. To date, only a few hydrophobic nanochannels controlling the transport of water have been reported, all of which use exotic hydrophobic molecules. However, the effect of electrostatic charges, which plays an indispensable role in membrane proteins and dominates the energetics of water permeation across aquaporins, has not gained enough attention to control water transport through solid-state nanochannel/nanopore...
September 20, 2016: ACS Nano
https://www.readbyqxmd.com/read/27620618/a-novel-integrated-forensic-microdevice-on-a-rotation-driven-platform-buccal-swab-to-str-product-in-less-than-2%C3%A2-h
#15
Jordan O Cox, Teresa Sikes DeCarmen, Yiwen Ouyang, Briony Strachan, Hillary Sloane, Cathey Connon, Kemper Gibson, Kimberly Jackson, James P Landers, Tracey Dawson Cruz
This work describes the development of a novel microdevice for forensic DNA processing of reference swabs. This microdevice incorporates an enzyme-based assay for DNA preparation, which allows for faster processing times and reduced sample handling. Infrared-mediated PCR (IR-PCR) is used for STR amplification using a custom reaction mixture, allowing for amplification of STR loci in 45 min while circumventing the limitations of traditional block thermocyclers. Uniquely positioned valves coupled with a simple rotational platform are used to exert fluidic control, eliminating the need for bulky external equipment...
September 12, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27609260/intentional-laceration-of-the-anterior-mitral-valve-leaflet-to-prevent-left-ventricular-outflow-tract-obstruction-during-transcatheter-mitral%C3%A2-valve-replacement-pre-clinical-findings
#16
Jaffar M Khan, Toby Rogers, William H Schenke, Jonathan R Mazal, Anthony Z Faranesh, Adam B Greenbaum, Vasilis C Babaliaros, Marcus Y Chen, Robert J Lederman
OBJECTIVES: The authors propose a novel transcatheter transection of the anterior mitral leaflet to prevent iatrogenic left ventricular outflow tract (LVOT) obstruction during transcatheter mitral valve replacement (TMVR). BACKGROUND: LVOT obstruction is a life-threatening complication of TMVR caused by septal displacement of the anterior mitral leaflet. METHODS: In vivo procedures in swine were guided by biplane x-ray fluoroscopy and intracardiac echocardiography...
September 12, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27592074/managing-nasal-valve-compromise-patients-with-nasal-dilators-objective-vs-subjective-parameters
#17
G Lekakis, E Dekimpe, B Steelant, P W Hellings
INTRODUCTION: Patients suffering from nasal obstruction due to nasal valve compromise may benefit from a nasal dilator. Several devices for widening of the external/internal nasal valve region can be applied endonasally (Airmax, Nasanita, Nozovent) or externally (Breathe Right). MATERIALS AND METHODS: 100 patients suffering from nasal obstruction due to external or internal nasal valve compromise were involved in this study. All patients were evaluated for nasal obstruction with visual analogue scores (VAS) and peak nasal inspiratory flow (PNIF) measurements before and after the application of 4 nasal dilators...
September 4, 2016: Rhinology
https://www.readbyqxmd.com/read/27590539/dna-purification-using-dynamic-solid-phase-extraction-on-a-rotationally-driven-polyethylene-terephthalate-microdevice
#18
K R Jackson, J C Borba, M Meija, D L Mills, D M Haverstick, K E Olson, R Aranda, G T Garner, E Carrilho, J P Landers
We report the development of a disposable polyester toner centrifugal device for semi-automated, dynamic solid phase DNA extraction (dSPE) from whole blood samples. The integration of a novel adhesive and hydrophobic valving with a simple and low cost microfabrication method allowed for sequential addition of reagents without the need for external equipment for fluid flow control. The spin-dSPE method yielded an average extraction efficiency of ∼45% from 0.6 μL of whole blood. The device performed single sample extractions or accommodate up to four samples for simultaneous DNA extraction, with PCR-readiness DNA confirmed by effective amplification of a β-globin gene...
September 21, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27586247/drosophila-pachea-asymmetric-lobes-are-part-of-a-grasping-device-and-stabilize-one-sided-mating
#19
Flor T Rhebergen, Virginie Courtier-Orgogozo, Julien Dumont, Menno Schilthuizen, Michael Lang
BACKGROUND: Multiple animal species exhibit morphological asymmetries in male genitalia. In insects, left-right genital asymmetries evolved many times independently and have been proposed to appear in response to changes in mating position. However, little is known about the relationship between mating position and the interaction of male and female genitalia during mating, and functional analyses of asymmetric morphologies in genitalia are virtually non-existent. We investigated the relationship between mating position, asymmetric genital morphology and genital coupling in the fruit fly Drosophila pachea, in which males possess an asymmetric pair of external genital lobes and mate in an unusual right-sided position on top of the female...
2016: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/27583536/german-heart-surgery-report-2015-the-annual-updated-registry-of-the-german-society-for-thoracic-and-cardiovascular-surgery
#20
Andreas Beckmann, Anne-Katrin Funkat, Jana Lewandowski, Michael Frie, Markus Ernst, Khosro Hekmat, Wolfgang Schiller, Jan F Gummert, Armin Welz
On the basis of a long-standing voluntary registry, which was founded by the German Society for Thoracic and Cardiovascular Surgery (GSTCVS), well-defined data of all heart, thoracic, and vascular surgery procedures performed in 78 German heart surgery departments during 2015 are analyzed. In 2015, a total of 103,967 heart surgery procedures (implantable cardioverter defibrillator, pacemaker, and extracardiac procedures without ECC excluded) were submitted to the database. Approximately 14.8% of the patients were at least 80 years old, resulting in an increase of 0...
September 2016: Thoracic and Cardiovascular Surgeon
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