keyword
MENU ▼
Read by QxMD icon Read
search

Carnosine

keyword
https://www.readbyqxmd.com/read/29676814/potential-of-carnosine-a-histamine-precursor-in-rat-model-of-bilateral-common-carotid-artery-occlusion-induced-vascular-dementia
#1
Nidhi Tiwari, Pankaj Bhatia, Amit Kumar, Amteshwar S Jaggi, Nirmal Singh
The present study investigates the potential of Carnosine a histamine precursor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. The rats were subjected to Morris water-maze (MWM) test (6th day onwards post-surgery). MWM test was employed to assess learning and memory of the animals whereby ELT (escape latency time), TSTQ (time spent in target quadrant) and Path length (distance travelled) taken as important parameters...
April 20, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29666584/differences-in-muscle-metabolism-between-triathletes-and-normally-active-volunteers-investigated-using-multinuclear-magnetic-resonance-spectroscopy-at-7t
#2
Radka Klepochová, Ladislav Valkovič, Thomas Hochwartner, Christoph Triska, Norbert Bachl, Harald Tschan, Siegfried Trattnig, Michael Krebs, Martin Krššák
Purpose: The influence of endurance training on skeletal muscle metabolism can currently be studied only by invasive sampling or through a few related parameters that are investigated by either proton (1 H) or phosphorus (31 P) magnetic resonance spectroscopy (MRS). The aim of this study was to compare the metabolic differences between endurance-trained triathletes and healthy volunteers using multi-parametric data acquired by both, 31 P- and 1 H-MRS, at ultra-high field (7T) in a single experimental protocol...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29621776/carnosine-catalyzes-the-formation-of-the-oligo-polymeric-products-of-methylglyoxal
#3
Tim Weigand, Benjamin Singler, Thomas Fleming, Peter Nawroth, Karel D Klika, Christian Thiel, Hans Baelde, Sven F Garbade, Andreas H Wagner, Markus Hecker, Benito A Yard, Albert Amberger, Johannes Zschocke, Claus P Schmitt, Verena Peters
BACKGROUND/AIMS: Reactive dicarbonyl compounds, such as methylglyoxal (MG), contribute to diabetic complications. MG-scavenging capacities of carnosine and anserine, which have been shown to mitigate diabetic nephropathy, were evaluated in vitro and in vivo. METHODS: MG-induced cell toxicity was characterized by MTT and MG-H1-formation, scavenging abilities by Western Blot and NMR spectroscopies, cellular carnosine transport by qPCR and microplate luminescence and carnosine concentration by HPLC...
March 29, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29601911/neuroprotective-effect-of-the-carnosine-%C3%AE-lipoic-acid-nanomicellar-complex-in-a-model-of-early-stage-parkinson-s-disease
#4
O I Kulikova, D S Berezhnoy, S L Stvolinsky, A V Lopachev, V S Orlova, T N Fedorova
In a model of early-stage Parkinson's disease induced by a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to Wistar rats, a neuroprotective effect of a new derivative of carnosine and α-lipoic acid (C/LA nanomicellar complex) was demonstrated. Acute intraperitoneal administration of carnosine, α-lipoic acid and C/LA complex following MPTP administration normalized the total antioxidant activity in the brain tissue. Of all the compounds tested only C/LA complex normalized the metabolism of dopamine (DA) and serotonin (5-HT), while its components did not show similar effects when used separately...
March 27, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29569535/changing-to-a-vegetarian-diet-reduces-the-body-creatine-pool-in-omnivorous-women-but-appears-not-to-affect-carnitine-and-carnosine-homeostasis-a-randomised-trial
#5
Laura Blancquaert, Audrey Baguet, Tine Bex, Anneke Volkaert, Inge Everaert, Joris Delanghe, Mirko Petrovic, Chris Vervaet, Stefaan De Henauw, Dumitru Constantin-Teodosiu, Paul Greenhaff, Wim Derave
Balanced vegetarian diets are popular, although they are nearly absent in creatine and carnosine and contain considerably less carnitine than non-vegetarian diets. Few longitudinal intervention studies investigating the effect of a vegetarian diet on the availability of these compounds currently exist. We aimed to investigate the effect of transiently switching omnivores onto a vegetarian diet for 6 months on muscle and plasma creatine, carnitine and carnosine homeostasis. In a 6-month intervention, forty omnivorous women were ascribed to three groups: continued omnivorous diet (control, n 10), vegetarian diet without supplementation (Veg+Pla, n 15) and vegetarian diet combined with daily β-alanine (0·8-0·4 g/d) and creatine supplementation (1 g creatine monohydrate/d) (Veg+Suppl, n 15)...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29567852/effects-of-supplementation-with-carnosine-and-other-histidine-containing-dipeptides-on-chronic-disease-risk-factors-and-outcomes-protocol-for-a-systematic-review-of-randomised-controlled-trials
#6
Kirthi Menon, Aya Mousa, Barbora de Courten
INTRODUCTION: Ageing of populations globally, coupled with the obesity epidemic, has resulted in the rising prevalence of chronic diseases including diabetes, cardiovascular diseases, cancers and neurodegenerative disorders. Prevention of risk factors that contribute to these diseases is key in managing the global burden of chronic diseases. Recent studies suggest that carnosine, a dipeptide with anti-inflammatory, antioxidative and antiglycating properties may have a role in the prevention of chronic diseases; however, no previous reviews have examined the effects of carnosine and other histidine-containing peptides (HCDs) on chronic disease risk factors and outcomes...
March 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29555069/effects-of-%C3%AE-alanine-supplementation-on-carnosine-elevation-and-physiological-performance
#7
Jay R Hoffman, Alyssa Varanoske, Jeffrey R Stout
β-Alanine is one of the more popular sport supplements used by strength/power athletes today. The popularity of β-alanine stems from its ability to enhance intracellular muscle-buffering capacity thereby delaying fatigue during high-intensity exercise by increasing muscle carnosine content. Recent evidence also suggests that elevated carnosine levels may enhance cognitive performance and increase resiliency to stress. These benefits are thought to result from carnosine's potential role as an antioxidant. This review will discuss these new findings including recent investigations examining β-alanine supplementation and increased resiliency to posttraumatic stress and mild traumatic brain injury...
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29515455/the-effects-of-%C3%AE-alanine-supplementation-on-muscle-ph-and-the-power-duration-relationship-during-high-intensity-exercise
#8
Matthew I Black, Andrew M Jones, Paul T Morgan, Stephen J Bailey, Jonathan Fulford, Anni Vanhatalo
Purpose: To investigate the influence of β-alanine (BA) supplementation on muscle carnosine content, muscle pH and the power-duration relationship (i.e., critical power and W'). Methods: In a double-blind, randomized, placebo-controlled study, 20 recreationally-active males (22 ± 3 y, V°O2peak 3.73 ± 0.44 L·min-1 ) ingested either BA (6.4 g/d for 28 d) or placebo (PL) (6.4 g/d) for 28 d. Subjects completed an incremental test and two 3-min all-out tests separated by 1-min on a cycle ergometer pre- and post-supplementation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29502490/carnosine-in-health-and-disease
#9
Guilherme Giannini Artioli, Craig Sale, Rebecca Louise Jones
Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells...
March 4, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29496567/carnosine-protects-pancreatic-beta-cells-and-islets-against-oxidative-stress-damage
#10
Vitale Miceli, Mariangela Pampalone, Giovanna Frazziano, Giuseppe Grasso, Enrico Rizzarelli, Camillo Ricordi, Anna Casu, Gioacchin Iannolo, Pier Giulio Conaldi
Islet transplantation is a valid therapeutic option for type 1 diabetes treatment. However, in this procedure one of the major problems is the oxidative stress produced during pancreatic islet isolation. The aim of our study was to evaluate potential protective effects of L-carnosine and its isomer D-carnosine against oxidative stress. We evaluated the carnosine effect on cell growth, cell death, insulin production, and the main markers of oxidative stress in rat and murine stressed beta cell lines as well as in human pancreatic islets...
February 26, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29484990/biosynthesis-of-carnosine-and-related-dipeptides-in-vertebrates
#11
Sebastian Kwiatkowski, Anna Kiersztan, Jakub Drozak
Carnosine (b-alanyl-L-histidine) and its methylated derivatives: anserine (b-alanyl-Np-methyl-L-histidine) and balenine (b-alanyl-Nt-methyl-L-histidine) are abundant constituents of excitable tissues of vertebrates. While carnosine and anserine are present at high concentrations and in variable proportions in skeletal muscle and brain of most vertebrates, balenine appears to be rather more abundant in marine mammals and certain reptilian species. Since the discovery of these compounds at the beginning of 20th century, numerous studies have been devoted to identification of the biochemical and physiological properties of carnosine and related dipeptides...
February 26, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29482601/efficacy-of-high-intensity-low-volume-interval-training-compared-to-continuous-aerobic-training-on-insulin-resistance-skeletal-muscle-structure-and-function-in-adults-with-metabolic-syndrome-study-protocol-for-a-randomized-controlled-clinical-trial-intraining
#12
Jaime Gallo-Villegas, Juan Carlos Aristizabal, Mauricio Estrada, Luis H Valbuena, Raul Narvaez-Sanchez, Jorge Osorio, Daniel C Aguirre-Acevedo, Juan C Calderón
BACKGROUND: Evidence of the efficacy of high-intensity, low-volume interval training (HIIT-low volume) in treating insulin resistance (IR) in patients with metabolic disorders is contradictory. In addition, it is unknown whether this effect is mediated through muscle endocrine function, which in turn depends on muscle mass and fiber type composition. Our aims were to assess the efficacy of HIIT-low volume compared to continuous aerobic exercise (CAE) in treating IR in adults with metabolic syndrome (MS) and to establish whether musclin, apelin, muscle mass and muscle composition are mediators of the effect...
February 27, 2018: Trials
https://www.readbyqxmd.com/read/29482032/carnosine-graphene-oxide-conjugates-decorated-with-hydroxyapatite-as-promising-nanocarrier-for-icg-loading-with-enhanced-antibacterial-effects-in-photodynamic-therapy-against-streptococcus-mutans
#13
Elham Gholibegloo, Ashkan Karbasi, Maryam Pourhajibagher, Nasim Chiniforush, Ali Ramazani, Tayebeh Akbari, Abbas Bahador, Mehdi Khoobi
Antimicrobial photodynamic therapy (aPDT) has been emerged as a noninvasive strategy to remove bacterial contaminants such as S. mutans from the tooth surface. Photosensitizer (PS), like indocyanine green (ICG), plays a key role in this technique which mainly suffers from the poor stability and concentration-dependent aggregation. An appropriate nanocarrier (NC) with enhanced antibacterial effects could overcome these limitations and improve the efficiency of ICG as a PS. In this study, various ICG-loaded NCs including graphene oxide (GO), GO-carnosine (Car) and GO-Car/Hydroxyapatite (HAp) were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Filed Emission Scanning Electron Microscopy (FE-SEM), Energy Dispersive Spectroscopy (EDS), Zeta Potential and Ultraviolet-Visible spectrometry (UV-Vis)...
February 9, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29477225/water-soluble-vitamin-e-tocopheryl-phosphate
#14
Jean-Marc Zingg
The hydrophobicity of vitamin E poses transport and metabolic challenges to regulate its bioavailability and to prevent its accumulation in lipid-rich tissues such as adipose tissue, brain, and liver. Water-soluble precursors of vitamin E (α-tocopherol, αT), such as its esters with acetate (αTA), succinate (αTS), or phosphate (αTP), have increased solubility in water and stability against reaction with free radicals, but they are rapidly converted during their uptake into the lipid-soluble vitamin E. Therefore, the bioavailability of these precursors as intact molecules is low; nevertheless, at least for αTS and αTP, the recent research has revealed unique regulatory effects on signal transduction and gene expression and the modulation of cellular events ranging from proliferation, survival/apoptosis, lipid uptake and metabolism, phagocytosis, long term potentiation, cell migration, telomere maintenance, and angiogenesis...
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29469982/prophylactic-administration-of-carnosine-and-melatonin-abates-the-incidence-of-renal-toxicity-induced-by-an-over-dose-of-titanium-dioxide-nanoparticles
#15
Laila Mohamed Fadda, Azza M Mohamed, Hanaa Mahmoud Ali, Hanan Hagar, Manal Aldossari
The alleviative effects of two antioxidants, carnosine (Car) and melatonin (Mel), against titanium dioxide nanoparticles (TiO2 -NPs) toxicity-induced oxidative and inflammatory renal damage were examined in rats. Administration of these antioxidants along with TiO2 -NPs effectively reduced serum urea, uric acid, creatinine, glucose, tumor necrosis factor-α, interleukin-6, C-reactive protein, immunoglobulin G, vascular endothelial growth factor, and nitric oxide, as well as a significant amelioration of the decrease in glutathione levels in renal tissue was observed, compared to those in rats treated with TiO2 -NPs alone...
February 22, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29469593/l-carnosine-as-adjunctive-therapy-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-randomized-double-blind-placebo-controlled-clinical-trial
#16
Alireza Ghajar, Farinaz Aghajan-Nashtaei, Mohsen Afarideh, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
OBJECTIVES: This study aimed to investigate the efficacy and tolerability of l-carnosine as an add-on to methylphenidate in management of children with attention-deficit/hyperactivity disorder (ADHD). METHODS: This was an 8-week, randomized, double-blind placebo-controlled study. Fifty-six drug-free children and adolescents aged 6-17 years old with a diagnosis of ADHD entered the study. The patients were randomly assigned to l-carnosine (800 mg/d in two divided doses) or placebo plus methylphenidate (0...
February 22, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29467440/metabolic-profile-associated-with-distinct-behavioral-coping-strategies-of-129sv-and-bl6-mice-in-repeated-motility-test
#17
Jane Narvik, Taavi Vanaveski, Jürgen Innos, Mari-Anne Philips, Aigar Ottas, Liina Haring, Mihkel Zilmer, Eero Vasar
We investigated the metabolic outcome of different coping strategies in 129S6/SvEvTac (129Sv) and C57BL/6Ntac (Bl6) strains. Two different batches of male 129Sv and Bl6 mice were used. One batch was not subjected to any behavioral manipulations (home cage control; HCC), whereas the other batch was treated with saline for 11 days and exposed after every treatment to the motor activity measurement (repeated motility tested; RMT). Bl6 RMT mice displayed a robust increase in number of rearings during repeated testing...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29454153/muscle-carnosine-in-experimental-autoimmune-encephalomyelitis-and-multiple-sclerosis
#18
Charly Keytsman, Laura Blancquaert, Inez Wens, Maarten Missine, Pieter Van Noten, Frank Vandenabeele, Wim Derave, Bert O Eijnde
BACKGROUND: Muscle carnosine is related to contractile function (Ca ++ handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS. METHODS: Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CON, n = 40) before and after exercise training (EAE EX , CON EX , 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAE SED , CON SED )...
February 11, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29433209/effect-of-hop-%C3%AE-acids-as-dietary-supplement-for-broiler-chickens-on-meat-composition-and-redox-stability
#19
A Zawadzki, C Alloo, A B Grossi, E S P do Nascimento, L C Almeida, S Bogusz Junior, L H Skibsted, D R Cardoso
Addition of β-acids extracted from hop at different levels (0, 30mgkg-1, 60mgkg-1, 240mgkg-1) to the diet of broiler chickens demonstrated significant effects on the average concentration of polar metabolites and fatty acids of relevance for meat quality. The largest metabolic differences between control group and chicken fed different levels of β-acids were achieved using 30mgkg-1 of supplement. As determined by EPR spin-trapping, increased redox stability was also obtained for meat from chicken fed 30mgkg-1 of β-acids which also had highest level of endogenous antioxidants, especially anserine, carnosine, NADH and PUFAs...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29430839/effects-of-l-carnosine-supplementation-on-sleep-disorders-and-disease-severity-in-autistic-children-a-randomized-controlled-clinical-trial
#20
Zahra Mehrazad-Saber, Sorayya Kheirouri, Seyyed-Gholamreza Noorazar
Sleep disorders are frequently reported in autistic patients. Evidences suggest that increased oxidative stress and reduced antioxidants may play a major role in the pathogenesis of these disorders. Carnosine acts as an antioxidant, antitoxic and neuroprotective agent. The aim of this trial study was to examine the effects of carnosine supplementation on the sleep disorders and severity of autism core symptoms in autistic patients. In this double-blind, randomized clinical trial, 43 autistic patients (31 boys and 12 girls; aged 4 to 16 years) were divided into two groups of carnosine and control that received 500 mg of carnosine and 500 mg of placebo per day for two months, respectively...
February 11, 2018: Basic & Clinical Pharmacology & Toxicology
keyword
keyword
10477
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"