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Carnosine

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https://www.readbyqxmd.com/read/28205623/preventive-effects-of-carnosine-on-lipopolysaccharide-induced-lung-injury
#1
Ken-Ichiro Tanaka, Toshifumi Sugizaki, Yuki Kanda, Fumiya Tamura, Tomomi Niino, Masahiro Kawahara
Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute lung injury, which involves neutrophilic inflammation and pulmonary cell death. Reactive oxygen species (ROS) play important roles in ARDS development. New compounds for inhibiting the onset and progression of ARDS are required. Carnosine (β-alanyl-L-histidine) is a small di-peptide with numerous activities, including antioxidant effects, metal chelation, proton buffering capacity and the inhibition of protein carbonylation and glycoxidation...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183595/carbon-nanotube-as-a-carrier-in-drug-delivery-system-for-carnosine-dipeptide-a-computer-simulation-study
#2
Sepideh Ketabi, Leila Rahmani
Biological application of carbon nanotube in drug delivery is our main concern in this investigation. For this purpose interaction of carnosine and carbon nanotube was studied in both gas phase and separately in aqueous media. Three possible interactions of carnosine dipeptide with (5,5) carbon nanotube in physiological media were considered. At first step each species were modeled using quantum mechanical calculations, in the next step, their properties in aqueous solution were studied by applying Monte Carlo simulations...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28173624/evidence-for-the-role-of-histaminergic-pathways-in-neuroprotective-mechanism-of-ischemic-postconditioning-in-mice
#3
Indresh Kaur, Amit Kumar, Amteshwar S Jaggi, Nirmal Singh
The present study has been designed to investigate the possible role of histaminergic pathway in neuroprotective mechanism of ischemic postconditioning (iPoCo). Bilateral carotid artery occlusion (BCAO) for 12 min followed by reperfusion for 24 hr was employed to produce I/R induced cerebral injury in NIH mice. iPoCo involving three episodes of carotid artery occlusion and reperfusion of 10 sec each, was instituted immediately after BCAO just before prolonged reperfusion. Cerebral infarct size was measured using triphenyltetrazolium chloride staining...
February 7, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28161798/behavioral-and-inflammatory-response-in-animals-exposed-to-a-low-pressure-blast-wave-and-supplemented-with-%C3%AE-alanine
#4
Jay R Hoffman, Amitai Zuckerman, Omri Ram, Oren Sadot, Jeffrey R Stout, Ishay Ostfeld, Hagit Cohen
This study investigated the benefit of β-alanine (BA) supplementation on behavioral and cognitive responses relating to mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) in rats exposed to a low-pressure blast wave. Animals were fed a normal diet with or without (PL) BA supplementation (100 mg kg(-1)) for 30-day, prior to being exposed to a low-pressure blast wave. A third group of animals served as a control (CTL). These animals were fed a normal diet, but were not exposed to the blast...
February 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28159969/targeted-metabolomics-reveals-early-dominant-optic-atrophy-signature-in-optic-nerves-of-opa1delttag-mice
#5
Juan Manuel Chao de la Barca, Gilles Simard, Emmanuelle Sarzi, Tanguy Chaumette, Guillaume Rousseau, Stéphanie Chupin, Cédric Gadras, Lydie Tessier, Marc Ferré, Arnaud Chevrollier, Valérie Desquiret-Dumas, Naïg Gueguen, Stéphanie Leruez, Christophe Verny, Dan Miléa, Dominique Bonneau, Patrizia Amati-Bonneau, Vincent Procaccio, Christian Hamel, Guy Lenaers, Pascal Reynier, Delphine Prunier-Mirebeau
Purpose: Dominant optic atrophy (MIM No. 165500) is a blinding condition related to mutations in OPA1, a gene encoding a large GTPase involved in mitochondrial inner membrane dynamics. Although several mouse models mimicking the disease have been developed, the pathophysiological mechanisms responsible for retinal ganglion cell degeneration remain poorly understood. Methods: Using a targeted metabolomic approach, we measured the concentrations of 188 metabolites in nine tissues, that is, brain, three types of skeletal muscle, heart, liver, retina, optic nerve, and plasma in symptomatic 11-month-old Opa1delTTAG/+ mice...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28157726/twenty-four-weeks-%C3%AE-alanine-supplementation-on-carnosine-content-related-genes-and-exercise
#6
Bryan Saunders, Vitor de Salles Painelli, Luana Farias de Oliveira, Vinicius da Eira Silva, Rafael Pires da Silva, Luiz Riani, Mariana Franchi, Lívia de Souza Gonçalves, Roger Charles Harris, Hamilton Roschel, Guilherme Giannini Artioli, Craig Sale, Bruno Gualano
INTRODUCTION: Skeletal muscle carnosine content can be increased through β-alanine supplementation, but the maximum increase achievable with supplementation is unknown. No study has investigated the effects of prolonged supplementation on carnosine-related genes or exercise capacity. PURPOSE: To investigate the effects of 24-weeks of β-alanine supplementation on muscle carnosine content, gene expression and high-intensity cycling capacity (CCT110%). METHODS: Twenty-five active males were supplemented with 6...
December 6, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28149008/transforming-growth-factor-%C3%AE-1-smad3-signaling-and-redox-status-in-experimentally-induced-nephrotoxicity-impact-of-carnosine
#7
Walaa Arafa Keshk, Mohamed Alaa Katary
: Exposure to various organic compounds including drugs and environmental toxins causes cellular damage through generation of free radicals. Carnosine a dipeptide was used in this study to evaluate its effect against CCl4-induced nephrotoxicity. Sixty male albino rats were involved in this study and were equally divided into four groups. CCl4 (3 ml/kg body weight; biweekly for 4 weeks) was given to group II and III. Carnosine (10 mg/kg body weight; once daily for 4 weeks) was given to group III and VI...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28142304/correction-to-abdel-baky-fadda-al-rasheed-al-rasheed-mohamed-and-yacoub-neuroprotective-effect-of-carnosine-and-cyclosporine-a-against-inflammation-apoptosis-and-oxidative-brain-damage-after-closed-head-injury-in-immature-rats
#8
https://www.readbyqxmd.com/read/28131569/histidine-deficiency-has-a-negative-effect-on-lactational-performance-of-dairy-cows
#9
F Giallongo, M T Harper, J Oh, C Parys, I Shinzato, A N Hristov
A 10-wk randomized complete block design experiment with 24 Holstein cows was conducted to investigate the long-term effects of feeding a His-deficient diet on lactational performance of dairy cows. Cows were blocked by days in milk, milk yield, and parity, and randomly assigned to 1 of the following 2 treatments: (1) His-adequate diet [HAD; providing +166 g/d over metabolizable protein (MP) requirements, according to the National Research Council (2001) and digestible His (dHis) supply of 68 g/d, or 2.5% of MP requirements] and (2) His-deficient diet (HDD; +37 g/d over MP requirements and dHis supply of 49 g/d, or 1...
January 25, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28122782/a-metabolomic-study-of-biomarkers-of-meat-and-fish-intake
#10
William Cheung, Pekka Keski-Rahkonen, Nada Assi, Pietro Ferrari, Heinz Freisling, Sabina Rinaldi, Nadia Slimani, Raul Zamora-Ros, Milena Rundle, Gary Frost, Helena Gibbons, Eibhlin Carr, Lorraine Brennan, Amanda J Cross, Valeria Pala, Salvatore Panico, Carlotta Sacerdote, Domenico Palli, Rosario Tumino, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Anna Floegel, Francesca Mancini, Marie-Christine Boutron-Ruault, Laura Baglietto, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Augustin Scalbert
BACKGROUND: Meat and fish intakes have been associated with various chronic diseases. The use of specific biomarkers may help to assess meat and fish intake and improve subject classification according to the amount and type of meat or fish consumed. OBJECTIVE: A metabolomic approach was applied to search for biomarkers of meat and fish intake in a dietary intervention study and in free-living subjects from the European Prospective Investigation into Cancer and Nutrition (EPIC) study...
January 25, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28120718/nutraceuticals-and-dietary-supplements-to-improve-quality-of-life-and-outcomes-in-heart-failure-patients
#11
Arrigo Fg Cicero, Alessandro Colletti
BACKGROUND: Heart failure (HF) is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill or eject blood. It represents a major public health issue, with a prevalence of over 23 million worldwide. The lifetime risk of developing HF is one in five and the most important risk factors identified are ischemic heart disease, hypertension, smoking, obesity and diabetes. Preventive approaches are based on improvements of lifestyle, associated with pharmacological therapy...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28120335/effects-of-dietary-supplementation-with-carnosine-on-growth-performance-meat-quality-antioxidant-capacity-and-muscle-fiber-characteristics-in-broiler-chickens
#12
Jiahui Cong, Lin Zhang, Jiaolong Li, Shuhao Wang, Feng Gao, Guanghong Zhou
BACKGROUND: The effects of dietary carnosine were evaluated on the growth performance, meat quality, antioxidant capacity and muscle fiber characteristics in thigh muscle of 256 one-day-old male broilers that were assigned to 4 diets: basal diet supplemented with 0, 100, 200 or 400 mg/kg carnosine during 42-d experiment, respectively. RESULT: Carnosine concentration and carnosine synthase expression in thigh muscle were linearly increased (P < 0.05), and the feed:gain was decreased (P < 0...
January 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28117708/methylglyoxal-mediated-stress-correlates-with-high-metabolic-activity-and-promotes-tumor-growth-in-colorectal-cancer
#13
Barbara Chiavarina, Marie-Julie Nokin, Justine Bellier, Florence Durieux, Noëlla Bletard, Félicie Sherer, Pierre Lovinfosse, Olivier Peulen, Laurine Verset, Romain Dehon, Pieter Demetter, Andrei Turtoi, Koji Uchida, Serge Goldman, Roland Hustinx, Philippe Delvenne, Vincent Castronovo, Akeila Bellahcène
Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality...
January 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28115195/carnosine-modulates-glutamine-synthetase-expression-in-senescent-astrocytes-exposed-to-oxygen-glucose-deprivation-recovery
#14
Xiaojie Shi, Bingyu Wang, Yuan Liu, Jingjing Zhang, Yuyan Huang, Pei Cao, Yao Shen, Jianxin Lyu
Carnosine is believed to be neuroprotective in cerebral ischemia. However, few reports concern its function on senescent astrocytes during cerebral ischemia. The aim of this study was to investigate the effects of carnosine on cell damage and glutamine synthetase (GS) expression in D-galactose-induced senescent astrocytes exposed to oxygen-glucose deprivation/recovery (OGD/R). The results showed that OGD/R caused massive cell damage and a significant decrease in GS expression both in the young and senescent astrocytes...
January 20, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28106620/effects-of-histidine-and-%C3%AE-alanine-supplementation-on-human-muscle-carnosine-storage
#15
Laura Blancquaert, Inge Everaert, Maarten Missinne, Audrey Baguet, Sanne Stegen, Anneke Volkaert, Mirko Petrovic, Chris Vervaet, Eric Achten, Mieke DE Maeyer, Stefaan DE Henauw, Wim Derave
PURPOSE: Carnosine is a dipeptide composed of β-alanine and L-histidine and is present in skeletal muscle. Chronic oral β-alanine supplementation can induce muscle carnosine loading and is therefore seen as the rate-limiting factor for carnosine synthesis. However, the effect of L-histidine supplementation on carnosine levels in humans is never established. This study aims to investigate whether 1) L-histidine supplementation can induce muscle carnosine loading and 2) combined supplementation of both amino acids is more efficient than β-alanine supplementation alone...
March 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28094570/antioxidant-anti-inflammatory-and-genomic-stability-enhancement-effects-of-zinc-l-carnosine-a-potential-cancer-chemopreventive-agent
#16
Theng Choon Ooi, Kok Meng Chan, Razinah Sharif
Cancer is one of the major causes of death worldwide, and the incidence and mortality rates of cancer are expected to rise tremendously in the near future. Despite a better understanding of cancer biology and advancement in cancer management, current strategies in cancer treatment remain costly and ineffective. Hence, instead of putting more efforts to search for new cancer cures, attention has now been shifted to the development of cancer chemopreventive agents as a preventive measure for cancer formation...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28072830/protective-effects-of-dexrazoxane-against-doxorubicin-induced-cardiotoxicity-a-metabolomic-study
#17
Yang QuanJun, Yang GenJin, Wan LiLi, Han YongLong, Huo Yan, Li Jie, Huang JinLu, Lu Jin, Gan Run, Guo Cheng
Cardioprotection of dexrazoxane (DZR) against doxorubicin (DOX)-induced cardiotoxicity is contentious and the indicator is controversial. A pairwise comparative metabolomics approach was used to delineate the potential metabolic processes in the present study. Ninety-six BALB/c mice were randomly divided into two supergroups: tumor and control groups. Each supergroup was divided into control, DOX, DZR, and DOX plus DZR treatment groups. DOX treatment resulted in a steady increase in 5-hydroxylysine, 2-hydroxybutyrate, 2-oxoglutarate, 3-hydroxybutyrate, and decrease in glucose, glutamate, cysteine, acetone, methionine, asparate, isoleucine, and glycylproline...
2017: PloS One
https://www.readbyqxmd.com/read/28064502/one-pot-synthesis-of-amino-acid-based-polyelectrolytes-and-nanoparticle-synthesis
#18
Stefan Mommer, Helmut Keul, Martin Möller
In this manuscript, a biscyclic monomer with an epoxide and a thiolactone ring connected by a urethane bond is used for the synthesis of amino acid-functional polyelectrolytes. In a first step, lithium salts of amino acids react selectively with the thiolactone ring by ring-opening, formation of an amide bond, and a thiol group. In a second step and in the presence of a base a polymeric building block is formed by polyaddition of the thiolate to the epoxide ring. The reaction occurs at room temperature in water as solvent...
January 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28063211/nmr-metabolomics-investigates-the-influence-of-flavonoid-enriched-rations-on-chicken-plasma
#19
Charalambos Fotakis, Dimitra Z Lantzouraki, Michael Goliomytis, Panagiotis E Simitzis, Maria Charismiadou, Stelios G Deligeorgis, Panagiotis Zoumpoulakis
The use of flavonoids as dietary supplements is well established, mainly due to their intense antioxidant and anti-inflammatory properties. In the present study, hesperidin, naringin, and vitamin E were used as additives at different concentrations in poultry rations in order to achieve meat of improved quality. NMR metabolomics was applied to chicken blood serum samples to discern whether and how the enriched rations affected the animals&#x2019; metabolic profile. Variations in the metabolic patterns according to sustenance consumption were traced by orthogonal projections to latent structures discriminant analysis (OPLS-DA) models and were attributed to specific metabolites by using S-line plots...
January 7, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28052095/metabolomic-profiling-in-individuals-with-a-failing-kidney-allograft
#20
Roberto Bassi, Monika A Niewczas, Luigi Biancone, Stefania Bussolino, Sai Merugumala, Sara Tezza, Francesca D'Addio, Moufida Ben Nasr, Alessandro Valderrama-Vasquez, Vera Usuelli, Valentina De Zan, Basset El Essawy, Massimo Venturini, Antonio Secchi, Francesco De Cobelli, Alexander Lin, Anil Chandraker, Paolo Fiorina
BACKGROUND: Alteration of certain metabolites may play a role in the pathophysiology of renal allograft disease. METHODS: To explore metabolomic abnormalities in individuals with a failing kidney allograft, we analyzed by liquid chromatography-mass spectrometry (LC-MS/MS; for ex vivo profiling of serum and urine) and two dimensional correlated spectroscopy (2D COSY; for in vivo study of the kidney graft) 40 subjects with varying degrees of chronic allograft dysfunction stratified by tertiles of glomerular filtration rate (GFR; T1, T2, T3)...
2017: PloS One
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