keyword
MENU ▼
Read by QxMD icon Read
search

Heterogenity

keyword
https://www.readbyqxmd.com/read/28227912/a-hybrid-discrete-continuous-model-of-in-vitro-spheroid-tumor-growth-and-drug-response
#1
Giorgos Tzedakis, Evangelos Liapis, Eleftheria Tzamali, Giannis Zacharakis, Vangelis Sakkalis, Giorgos Tzedakis, Evangelos Liapis, Eleftheria Tzamali, Giannis Zacharakis, Vangelis Sakkalis, Giannis Zacharakis, Vangelis Sakkalis, Evangelos Liapis, Giorgos Tzedakis, Eleftheria Tzamali
Anti-cancer therapy efficacy in solid tumors mainly depends on drug transportation through the vasculature system and the extracellular matrix, on diffusion gradients and clonal heterogeneity within the tumor mass, as well as on the responses of the individual tumor cells to drugs and their interactions with each other and their local microenvironment. In this work, we develop a mathematical predictive model for tumor growth and drug response based on 3D spheroids experiments that possess several in vivo features of tumors and are considered better for drug screening...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227715/bivariate-autoregressive-state-space-modeling-of-psychophysiological-time-series-data
#2
Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri, Kunal Mankodiya, Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri, Kunal Mankodiya, Kunal Mankodiya, Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri
Heart rate (HR) and electrodermal activity (EDA) are often used as physiological measures of psychological arousal in various neuropsychology experiments. In this exploratory study, we analyze HR and EDA data collected from four participants, each with a history of suicidal tendencies, during a cognitive task known as the Paced Auditory Serial Addition Test (PASAT). A central aim of this investigation is to guide future research by assessing heterogeneity in the population of individuals with suicidal tendencies...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227385/statistical-characterization-of-ensembles-of-symmetric-virus-particles-3-d-stochastic-signal-reconstruction-from-electron-microscope-images
#3
Nan Xu, Peter C Doerschuk, Nan Xu, Peter C Doerschuk, Nan Xu, Peter C Doerschuk
Stochastic models of nano-biomachines have been studied by 3-D reconstruction from cryo electron microscopy images in recent years. The image data is the projection of many heterogeneous instances of the object under study (e.g., a virus). Initial reconstruction algorithms require different instances of the object, while still heterogeneous, to have the same symmetry. This paper presents a maximum likelihood reconstruction approach which allows each object to lack symmetry while constraining the statistics of the ensemble of objects to have symmetry...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227380/efficient-rendering-of-digitally-reconstructed-radiographs-on-heterogeneous-computing-architectures-using-central-slice-theorem
#4
Marwan Abdellah, Mohamed Abdallah, Mohamed Alzanati, Ayman Eldeib, Marwan Abdellah, Mohamed Abdallah, Mohamed Alzanati, Ayman Eldeib, Ayman Eldeib, Mohamed Abdallah, Mohamed Alzanati, Marwan Abdellah
Digitally reconstructed radiographs (DRRs) play a significant role in modern clinical radiation therapy. They are used to verify patient alignments during image guided therapies with 2D-3D image registration. The generation of DRRs can be implemented intuitively in O(N(3)) relying on direct volume rendering (DVR) methods, such as ray marching. This complexity imposes certain limitations on the rendering performance if high quality DRR images are needed. Those DRRs can be alternatively generated in the k-space using the central slice theorem in O(N(2)logN)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227379/parallel-generation-of-digitally-reconstructed-radiographs-on-heterogeneous-multi-gpu-workstations
#5
Marwan Abdellah, Asem Abdelaziz, E M B S Eslam Ali, Sherief Abdelaziz, Abdelrahman Sayed, Mohamed I Owis, Ayman Eldeib, Marwan Abdellah, Asem Abdelaziz, E M B S Eslam Ali, Sherief Abdelaziz, Abdelrahman Sayed, Mohamed I Owis, Ayman Eldeib, Sherief Abdelaziz, Mohamed I Owis, Abdelrahman Sayed, Marwan Abdellah, Asem Abdelaziz, Eslam Ali, Ayman Eldeib
The growing importance of three-dimensional radiotherapy treatment has been associated with the active presence of advanced computational workflows that can simulate conventional x-ray films from computed tomography (CT) volumetric data to create digitally reconstructed radiographs (DRR). These simulated x-ray images are used to continuously verify the patient alignment in image-guided therapies with 2D-3D image registration. The present DRR rendering pipelines are quite limited to handle huge imaging stacks generated by recent state-of-the-art CT imaging modalities...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227365/integrated-quantification-based-on-confocal-imaging-cell-crowding-modulates-heterogeneity-in-gpcr-mediated-calcium-oscillation
#6
Jophin G Joseph, S Nanda, S Vennamalla, G Bhure, Ranjana Singh, Soumya Jana, Lopamudra Giri, Jophin G Joseph, S Nanda, S Vennamalla, G Bhure, Ranjana Singh, Soumya Jana, Lopamudra Giri, Soumya Jana, Lopamudra Giri, Jophin G Joseph, S Nanda, Ranjana Singh, G Bhure, S Vennamalla
Results from single cell imaging, facilitated by high resolution microscopy, have demonstrated cell-to-cell variability within the same cell population in contexts ranging from cell growth to cell migration. Recent studies suggest that such variability conveys important information about diseased states. However, manual analysis and interpretation of heterogeneous calcium oscillation based on time-lapsed images, as practiced today, is tedious, and essentially infeasible for large datasets. As a practical alternative, we present an integrated platform that includes calcium imaging using confocal microscope, algorithmic cell segmentation, and statistical analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227253/does-the-degree-of-coarctation-of-the-aorta-influence-wall-shear-stress-focal-heterogeneity
#7
John Gounley, Rafeed Chaudhury, Madhurima Vardhan, Michael Driscoll, Girish Pathangey, Kevin Winarta, Justin Ryan, David Frakes, Amanda Randles, John Gounley, Rafeed Chaudhury, Madhurima Vardhan, Michael Driscoll, Girish Pathangey, Kevin Winarta, Justin Ryan, David Frakes, Amanda Randles, Justin Ryan, Rafeed Chaudhury, Girish Pathangey, Amanda Randles, David Frakes, Kevin Winarta, Michael Driscoll, John Gounley, Madhurima Vardhan
The development of atherosclerosis in the aorta is associated with low and oscillatory wall shear stress for normal patients. Moreover, localized differences in wall shear stress heterogeneity have been correlated with the presence of complex plaques in the descending aorta. While it is known that coarctation of the aorta can influence indices of wall shear stress, it is unclear how the degree of narrowing influences resulting patterns. We hypothesized that the degree of coarctation would have a strong influence on focal heterogeneity of wall shear stress...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227229/ensemble-statistical-and-subspace-clustering-model-for-analysis-of-autism-spectrum-disorder-phenotypes
#8
Khalid Al-Jabery, Tayo Obafemi-Ajayi, Gayla R Olbricht, T Nicole Takahashi, Stephen Kanne, Donald Wunsch, Khalid Al-Jabery, Tayo Obafemi-Ajayi, Gayla R Olbricht, T Nicole Takahashi, Stephen Kanne, Donald Wunsch, Donald Wunsch, Tayo Obafemi-Ajayi, Khalid Al-Jabery, Stephen Kanne, Gayla R Olbricht, T Nicole Takahashi
Heterogeneity in Autism Spectrum Disorder (ASD) is complex including variability in behavioral phenotype as well as clinical, physiologic, and pathologic parameters. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) now diagnoses ASD using a 2-dimensional model based social communication deficits and fixated interests and repetitive behaviors. Sorting out heterogeneity is crucial for study of etiology, diagnosis, treatment and prognosis. In this paper, we present an ensemble model for analyzing ASD phenotypes using several machine learning techniques and a k-dimensional subspace clustering algorithm...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227205/low-frequency-ultrasound-radiosensitization-and-therapy-response-monitoring-of-tumors-an-in-vivo-study
#9
Ali Sadeghi-Naini, Martin Stanisz, Hadi Tadayyon, Jaswinder Taank, Gregory J Czarnota, Ali Sadeghi-Naini, Martin Stanisz, Hadi Tadayyon, Jaswinder Taank, Gregory J Czarnota, Jaswinder Taank, Hadi Tadayyon, Martin Stanisz, Ali Sadeghi-Naini, Gregory J Czarnota
A new framework has been introduced in this paper for tumor radiosensitization and therapy response monitoring using low-frequency ultrasound. Human fibrosarcoma xenografts grown in severe combined immunodeficiency (SCID) mice (n = 108) were treated using ultrasound-stimulated microbubbles at various concentration and exposed to different doses of radiation. Low-frequency ultrasound radiofrequency (RF) data were acquired from tumors prior to and at different times after treatment. Quantitative ultrasound (QUS) techniques were applied to generate spectral parametric maps of tumors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227098/heterogeneous-neural-amplifier-integration-for-scalable-extracellular-microelectrodes
#10
Jorg Scholvin, Justin P Kinney, Jacob G Bernstein, Caroline Moore-Kochlacs, Nancy J Kopell, Clifton G Fonstad, Edward S Boyden, Jorg Scholvin, Justin P Kinney, Jacob G Bernstein, Caroline Moore-Kochlacs, Nancy J Kopell, Clifton G Fonstad, Edward S Boyden, Jacob G Bernstein, Caroline Moore-Kochlacs, Edward S Boyden, Clifton G Fonstad, Justin P Kinney, Nancy J Kopell, Jorg Scholvin
We here demonstrate multi-chip heterogeneous integration of microfabricated extracellular recording electrodes with neural amplifiers, highlighting a path to scaling electrode channel counts without the need for more complex monolithic integration. We characterize the noise and impedance performance of the heterogeneously integrated neural recording electrodes, and analyze the design parameters that enable the low-voltage neural input signals to co-exist with the high-frequency and high-voltage digital outputs on the same silicon substrate...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227028/a-data-model-to-support-the-evaluation-of-coordinating-care-eu-programmes-in-the-context-of-the-act-programme
#11
P Natsiavas, D Filos, I Chouvarda, Ch Maramis, R van der Heijden, H Schonenberg, S Pauws, C Bescos, N Maglaveras, P Natsiavas, D Filos, I Chouvarda, C Maramis, R van der Heijden, H Schonenberg, S Pauws, C Bescos, N Maglaveras, R van der Heijden, P Natsiavas, S Pauws, Ch Maramis, C Bescos, D Filos, N Maglaveras, I Chouvarda, H Schonenberg
Advancing Care Coordination and Telehealth Deployment (ACT) is a European Union (EU) project, completed last October, which has developed a framework for evaluating and improving pioneering health care programs regarding coordinating care and telehealth (CC & TH) across specific EU regions. In this paper we present the key design decisions of the project's data model and the challenges faced. We focus on the definition of the multi-dimensional indicators in order to overcome data incompleteness and heterogeneity issues...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226852/heterogeneous-3d-optrode-with-variable-spatial-resolution-for-optogenetic-stimulation-and-electrophysiological-recording
#12
Suleman Ayub, Falk Barz, Oliver Paul, Patrick Ruther, Suleman Ayub, Falk Barz, Oliver Paul, Patrick Ruther, Suleman Ayub, Oliver Paul, Patrick Ruther, Falk Barz
We report on the concept, development, and geometrical, optical as well as electrical characterization of the first three-dimensional (3D) optrode. This new device allows to optically interact with neuronal cells and simultaneously record their response with a high spatial resolution. Our design is based on a single-shank optical stimulation component and a multi-shank recording probe stacked together in a delicate assembly process. The electrical connection of both components is ensured by using flexible polyimide (PI) ribbon cables...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226735/texton-and-sparse-representation-based-texture-classification-of-lung-parenchyma-in-ct-images
#13
Jie Yang, Xinyang Feng, Elsa D Angelini, Andrew F Laine, Jie Yang, Xinyang Feng, Elsa D Angelini, Andrew F Laine, Xinyang Feng, Jie Yang, Elsa D Angelini, Andrew F Laine
Automated texture analysis of lung computed tomography (CT) images is a critical tool in subtyping pulmonary emphysema and diagnosing chronic obstructive pulmonary disease (COPD). Texton-based methods encode lung textures with nearest-texton frequency histograms, and have achieved high performance for supervised classification of emphysema subtypes from annotated lung CT images. In this work, we first explore characterizing lung textures with sparse decomposition from texton dictionaries, using different regularization strategies, and then extend the sparsity-inducing constraint to the construction of the dictionaries...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226734/prediction-of-malignant-and-benign-of-lung-tumor-using-a-quantitative-radiomic-method
#14
Jun Wang, Xia Liu, Di Dong, Jiangdian Song, Min Xu, Yali Zang, Jie Tian, Jun Wang, Xia Liu, Di Dong, Jiangdian Song, Min Xu, Yali Zang, Jie Tian, Min Xu, Jiangdian Song, Di Dong, Jie Tian, Jun Wang, Yali Zang, Xia Liu
Lung cancer is the leading cause of cancer mortality around the world, the early diagnosis of lung cancer plays a very important role in therapeutic regimen selection. However, lung cancers are spatially and temporally heterogeneous; this limits the use of invasive biopsy. But radiomics which refers to the comprehensive quantification of tumour phenotypes by applying a large number of quantitative image features has the ability to capture intra-tumoural heterogeneity in a non-invasive way. Here we carry out a radiomic analysis of 150 features quantifying lung tumour image intensity, shape and texture...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226733/association-between-tumor-heterogeneity-and-progression-free-survival-in-non-small-cell-lung-cancer-patients-with-egfr-mutations-undergoing-tyrosine-kinase-inhibitors-therapy
#15
Jiangdian Song, Di Dong, Yanqi Huang, Yali Zang, Zaiyi Liu, Jie Tian, Jiangdian Song, Di Dong, Yanqi Huang, Yali Zang, Zaiyi Liu, Jie Tian, Zaiyi Liu, Yanqi Huang, Yali Zang, Jiangdian Song, Jie Tian, Di Dong
For non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations, current staging methods do not accurately predict the risk of disease recurrence after tyrosine kinase inhibitors (TKI) therapy. Developing a noninvasive method to predict whether individual could benefit from TKI therapy has great clinical significance. In this research, a radiomics approach was proposed to determine whether the tumor heterogeneity of NSCLC, which was measured by the texture on computed tomography (CT), could make an independent prediction of progression-free survival (PFS)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226710/quantitative-analysis-of-histological-tissue-image-based-on-cytological-profiles-and-spatial-statistics
#16
Young Hwan Chang, Guillaume Thibault, Vahid Azimi, Brett Johnson, Danielle Jorgens, Jason Link, Adam Margolin, Joe W Gray, Young Hwan Chang, Guillaume Thibault, Vahid Azimi, Brett Johnson, Danielle Jorgens, Jason Link, Adam Margolin, Joe W Gray, Danielle Jorgens, Brett Johnson, Adam Margolin, Young Hwan Chang, Vahid Azimi, Jason Link, Joe W Gray, Guillaume Thibault
The cellular heterogeneity and complex tissue architecture of most tumor samples is a major obstacle in image analysis on standard hematoxylin and eosin-stained (H&E) tissue sections. A mixture of cancer and normal cells complicates the interpretation of their cytological profiles. Furthermore, spatial arrangement and architectural organization of cells are generally not reflected in cellular characteristics analysis. To address these challenges, first we describe an automatic nuclei segmentation of H&E tissue sections...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226415/topographical-pressure-pain-sensitivity-maps-of-the-temporalis-muscle-in-people-with-frequent-episodic-and-chronic-tension-type-headache
#17
María Palacios Ceña, Matteo Castaldo, Kelun Wang, Pascal Madeleine, Ángel L Guerrero, Lars Arendt-Nielsen, César Fernández de Las Peñas
BACKGROUND: Previous pilot studies suggest the presence of heterogeneous sensitivity to pressure in primary headaches without considering the frequency of headache episodes. OBJECTIVE: To investigate the differences in topographical pressure pain sensitivity maps in the temporalis muscle between individuals with frequent episodic (FETTH) and chronic (CTTH) tension-type headache by controlling the presence of anxiety and depression. METHODS: Pressure pain thresholds (PPTs) were assessed bilaterally from 9 points distributed over the temporalis muscle (3 points in the anterior portion, 3 in the middle portion, and the remaining 3 in the posterior portion of the muscle belly) in 113 patients with FETTH and 91 with CTTH in a blinded design...
February 22, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28226399/wavelet-based-scaling-indices-for-breast-cancer-diagnostics
#18
T Roberts, M Newell, W Auffermann, B Vidakovic
Mammography is routinely used to screen for breast cancer. However, the radiological interpretation of mammogram images is complicated by the heterogeneous nature of normal breast tissue and the fact that cancers are often of the same radiographic density as normal tissue. In this work, we use wavelets to quantify spectral slopes of breast cancer cases and controls and demonstrate their value in classifying images. In addition, we propose asymmetry statistics to be used in forming features, which improve the classification result...
February 22, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28226328/a-de-novo-pericentric-inversion-in-chromosome-4-associated-with-disruption-of-pitx2-and-a-microdeletion-in-4p15-2-in-a-patient-with-axenfeld-rieger-syndrome-and-developmental-delay
#19
Živilė Maldžienė, Eglė Preikšaitienė, Salomėja Ignotienė, Natalija Kapitanova, Algirdas Utkus, Vaidutis Kučinskas
Axenfeld-Rieger syndrome (ARS) is a clinically and genetically heterogeneous group of autosomal dominantly inherited malformations that predominantly affect the eye but are also associated with craniofacial dysmorphism and dental abnormalities. A broad spectrum of genetic alterations involving PITX2 and FOXC1 lead to ARS. We report on a 4-year-old girl with clinical features of ARS and developmental delay due to a de novo apparently balanced pericentric inversion in chromosome 4. This report emphasizes that complementary investigations are necessary to precisely characterize chromosomal rearrangements...
February 23, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28226276/different-associations-of-albuminuria-with-total-and-cardiovascular-mortality-by-concentrations-of-persistent-organic-pollutants-in-the-elderly
#20
Hyun-Woo Kim, Jung-Hyun Kim, Dong-Won Lee, Sang-Hyun Cho, Ji-Hoon Jung, Ki-Su Kim, Duk-Hee Lee
Epidemiologic studies have indicated that albuminuria is associated with mortality from all causes and cardiovascular disease (CVD), with substantial heterogeneity. We evaluated if the associations of urine albumin creatinine ratio (ACR) with all-cause and CVD mortality differed depending on serum concentrations of persistent organic pollutants (POPs), strong lipophilic chemical mixtures with very long half-lives, which are recently linked to many degenerative diseases. Study subjects were participants of the National Health and Nutrition Examination Survey 1999-2004 who were 60 years or older at baseline (n=1215 and 1067 for organochlorine pesticides (OCPs) and other POPs, respectively)...
February 18, 2017: Environmental Research
keyword
keyword
104763
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"