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IL-27

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https://www.readbyqxmd.com/read/29221667/interleukin-27-and-interleukin-37-are-elevated-in-sickle-cell-anemia-patients-and-inhibit-in-vitro-secretion-of-interleukin-8-in-neutrophils-and-monocytes
#1
A E Alagbe, A S Justo Junior, L P Ruas, W V Tonassé, R M Santana, T H C Batista, I F Domingos, A S Araujo, M A C Bezerra, M N N Santos, M H S L Blotta
BACKGROUND AND OBJECTIVE: Inflammation is implicated in the pathogenesis of most complications seen in sickle cell anemia (SCA) patients. We aimed to evaluate serum levels of two newly discovered anti-inflammatory cytokines (IL-27 and IL-37), and pro-inflammatory cytokines among Brazilian SCA patients that are not on hydroxyurea therapy (HbSS), compared with hydroxyurea-treated patients (HbSSHU) and healthy controls (HbAA). Furthermore, we demonstrated the effect of IL-27, IL-37, and heme on in vitro secretions of IL-8 in human neutrophils and monocytes...
December 5, 2017: Cytokine
https://www.readbyqxmd.com/read/29218601/regulation-of-myelopoiesis-by-proinflammatory-cytokines-in-infectious-diseases
#2
REVIEW
Yukino Chiba, Izuru Mizoguchi, Hideaki Hasegawa, Mio Ohashi, Naoko Orii, Taro Nagai, Miyaka Sugahara, Yasunori Miyamoto, Mingli Xu, Toshiyuki Owaki, Takayuki Yoshimoto
Hematopoiesis is hierarchically orchestrated by a very small population of hematopoietic stem cells (HSCs) that reside in the bone-marrow niche and are tightly regulated to maintain homeostatic blood production. HSCs are predominantly quiescent, but they enter the cell cycle in response to inflammatory signals evoked by severe systemic infection or injury. Thus, hematopoietic stem and progenitor cells (HSPCs) can be activated by pathogen recognition receptors and proinflammatory cytokines to induce emergency myelopoiesis during infection...
December 7, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29216864/diagnostic-value-of-interleukins-for-tuberculous-pleural-effusion-a-systematic-review-and-meta-analysis
#3
Ni Zeng, Chun Wan, Jiangyu Qin, Yanqiu Wu, Ting Yang, Yongchun Shen, Fuqiang Wen, Lei Chen
BACKGROUND: The ability of interleukins (ILs) to differentiate tuberculous pleural effusion from other types of effusion is controversial. The aim of our study was to summarize the evidence for its use of ruling out or in tuberculous pleural effusion. METHODS: Two investigators independently searched PubMed, EMBASE, Web of Knowledge, CNKI, WANFANG, and WEIPU databases to identify studies assessing diagnostic role of ILs for tuberculous pleural effusion published up to January, 2017...
December 8, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29214756/serum-cytokine-profile-in-patients-with-chronic-rhinosinusitis-with-nasal-polyposis-infected-by-aspergillus-flavus
#4
Gargi Rai, Mohammad Ahmad Ansari, Sajad Ahmad Dar, Shyama Datt, Neelima Gupta, Sonal Sharma, Shafiul Haque, Vishnampettai Ganapathysubramanian Ramachandran, Arpeeta Mazumdar, Shivprakash Rudramurthy, Arunaloke Chakrabarti, Shukla Das
BACKGROUND: Fungi, especially Aspergillus flavus, can cause chronic rhinosinusitis with nasal polyposis and modulate host innate immune components. The objective of this study was to examine the serum levels of T helper (Th) cell subset Th1, Th2, and Th17 cytokines and total IgE in patients having chronic rhinosinusitis with nasal polyposis and Aspergillus flavus infection. METHODS: A case-control study including 40 patients with chronic rhinosinusitis with nasal polyposis and 20 healthy controls was conducted...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29195127/rapamycin-synergizes-with-cisplatin-in-antiendometrial-cancer-activation-by-improving-il-27-stimulated-cytotoxicity-of-nk-cells
#5
Wen-Jie Zhou, Kai-Kai Chang, Ke Wu, Hui-Li Yang, Jie Mei, Feng Xie, Da-Jin Li, Ming-Qing Li
Natural killer (NK) cell function is critical for controlling initial tumor growth and determining chemosensitivity of the tumor. A synergistic relationship between rapamycin and cisplatin in uterine endometrial cancer (UEC) in vitro has been reported, but the mechanism and the combined therapeutic strategy for endometrial cancer (EC) are still unknown. We found a positive correlation between the level of IL-27 and the differentiated stage of UEC. The increase of IL-27 in uterine endometrial cancer cell (UECC) lines (Ishikawa, RL95-2 and KLE) led to a high cytotoxic activity of NK cells to UECC in the co-culture system...
November 28, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29193757/effects-of-the-consumption-of-milk-biofortified-with-selenium-vitamin-e-and-different-fatty-acid-profile-on-immune-response-in-the-elderly
#6
Karina Pfrimer, Eduardo Ferriolli, Paula Lumy Takeuchi, Márcia Msv Salles, Arlindo Saran-Netto, Marcus A Zanetti, Luiz C Roma-Junior, Camila Bitu Moreno Braga, Fernanda A Domenici, Yara Ml Valim, Adriana Bp Paschoalato, Larissa F Marchi, Ana Ecs Azzolini, Eduardo A Donadi, Edson Martinez, Helio Vannucchi
SCOPE: Nutrition is a major contributing factor for immunocompetence. The aim was to assess the immune status of older after consuming a milk produced by lactating cows fed with one of the following diets: control diet(C), C+vitaminE+selenium(C+A), C+sunfloweroil(C+O), orC+sunflower oil+vitaminE+selenium(A+O). METHODS AND RESULTS: 60elderly received one of these biofortified milks during 12weeks. Immune response was assessed by measurement of the expression of COX-1,2, MCP-1, PPAR(δ,α and β/δ)genes, neutrophil production of oxygen reactive species induced by immune complexes, neutrophil phagocytosis and lytic activity of the alternative pathway of the complement system and cytokine levels...
November 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29187726/expression-of-interleukin-27-il-27-in-the-lower-airways-diseases-increased-levels-of-il-27-in-early-clinical-stages-of-non-small-cell-lung-cancer-nsclc-patients
#7
Piotr Kopiński, Tomasz Wandtke, Andrzej Dyczek, Ewelina Wędrowska, Adriana Roży, Tomasz Senderek, Grzegorz Przybylski, Joanna Chorostowska-Wynimko
INTRODUCTION    Interleukin-27, is a cytokine secreted mostly by antigen presenting cells, key for the Th1 cells immune polarization. Its role in interstitial lung diseases (ILD) as well as in lung cancer has been investigated.  OBJECTIVES    Assessment of IL-27 expression in the lower airways of patients with selected ILD and early-stage non-small cell lung cancer (NSCLC).  PATIENTS AND METHODS    IL-27 concentration was examined by ELISA in bronchoalveolar lavage (BAL) supernatants collected from patients with pulmonary sarcoidosis (PS), extrinsic allergic alveolitis (EAA), idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP) and I-IIa NSCLC with peripheral localization, as well as in control subjects (n = 14, 30, 12, 14, 16 and 14, respectively)...
November 29, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29186193/rig-i-like-receptor-activation-by-dengue-virus-drives-follicular-t-helper-cell-formation-and-antibody-production
#8
Joris K Sprokholt, Tanja M Kaptein, John L van Hamme, Ronald J Overmars, Sonja I Gringhuis, Teunis B H Geijtenbeek
Follicular T helper cells (TFH) are fundamental in orchestrating effective antibody-mediated responses critical for immunity against viral infections and effective vaccines. However, it is unclear how virus infection leads to TFH induction. We here show that dengue virus (DENV) infection of human dendritic cells (DCs) drives TFH formation via crosstalk of RIG-I-like receptor (RLR) RIG-I and MDA5 with type I Interferon (IFN) signaling. DENV infection leads to RLR-dependent IKKε activation, which phosphorylates IFNα/β receptor-induced STAT1 to drive IL-27 production via the transcriptional complex ISGF3...
November 29, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29185463/il-27-but-not-il-35-inhibits-neuroinflammation-through-modulating-gm-csf-expression
#9
Giacomo Casella, Annamaria Finardi, Hélène Descamps, Federico Colombo, Chiara Maiorino, Francesca Ruffini, Marco Patrone, Massimo Degano, Gianvito Martino, Luca Muzio, Burkhard Becher, Roberto Furlan
IL-27 and IL-35 are heterodimeric cytokines, members of the IL-12 family and considered to have immunomodulatory properties. Their role during neuroinflammation had been investigated using mutant mice devoid of either one of their subunits or lacking components of their receptors, yielding conflicting results. We sought to understand the therapeutic potential of IL-27 and IL-35 delivered by gene therapy in neuroinflammation. We constructed lentiviral vectors expressing IL-27 and IL-35 from a single polypeptide chain, and we validated in vitro their biological activity...
November 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29176764/interleukin-27-is-increased-in-carotid-atherosclerosis-and-promotes-nlrp3-inflammasome-activation
#10
Ida Gregersen, Øystein Sandanger, Erik T Askevold, Ellen Lund Sagen, Kuan Yang, Sverre Holm, Turid M Pedersen, Mona Skjelland, Kirsten Krohg-Sørensen, Trond Vidar Hansen, Tuva Børresdatter Dahl, Kari Otterdal, Terje Espevik, Pål Aukrust, Arne Yndestad, Bente Halvorsen
AIM: Interleukin-27 (IL-27) is involved in different inflammatory diseases; however, its role in atherosclerosis is unclear. In this study we investigated the expression of IL-27 and its receptor in patients with carotid atherosclerosis and if IL-27 could modulate the inflammatory effects of the NLRP3 inflammasome in vitro. METHODS: Plasma IL-27 was measured by enzyme immunoassay in patients with carotid stenosis (n = 140) and in healthy controls (n = 19). Expression of IL-27 and IL-27R was analyzed by quantitative PCR and immunohistochemistry in plaques from patients and in non-atherosclerotic vessels...
2017: PloS One
https://www.readbyqxmd.com/read/29167232/identification-of-ifn-%C3%AE-and-il-27-as-critical-regulators-of-respiratory-syncytial-virus-induced-exacerbation-of-allergic-airways-disease-in-a-mouse-model
#11
Thi Hiep Nguyen, Steven Maltby, Hock L Tay, Fiona Eyers, Paul S Foster, Ming Yang
Respiratory syncytial virus (RSV) infection induces asthma exacerbations, which leads to worsening of clinical symptoms and may result in a sustained decline in lung function. Exacerbations are the main cause of morbidity and mortality associated with asthma, and significantly contribute to asthma-associated healthcare costs. Although glucocorticoids are used to manage exacerbations, some patients respond to them poorly. The underlying mechanisms associated with steroid-resistant exacerbations remain largely unknown...
November 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29164392/maturation-and-cytokine-pattern-of-human-dendritic-cells-in-response-to-different-yeasts
#12
Silvia Boschi Bazan, Barbara Walch-Rückheim, Manfred J Schmitt, Frank Breinig
Activated dendritic cells (DC) induce and polarize T-cell responses by expression of distinct maturation markers and cytokines. This study systematically investigated the capacity of different biotechnically relevant yeast species and strains including Saccharomyces cerevisiae, Schizosaccharomyces pombe, Kluyveromyces lactis, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, and Candida glabrata to initiate maturation of human DC. As important prerequisite for T-cell activation, all yeasts were shown to effectively induce, though to a different extent, the expression of the activation marker CD83, the co-stimulatory molecules CD80, CD86, CD54, CD58, and CD40, as well as the antigen-presenting molecules MHCs I and II...
November 21, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29163476/induction-of-peripheral-tolerance-in-ongoing-autoimmune-inflammation-requires-interleukin-27-signaling-in-dendritic-cells
#13
Rodolfo Thomé, Jason N Moore, Elisabeth R Mari, Javad Rasouli, Daniel Hwang, Satoshi Yoshimura, Bogoljub Ciric, Guang-Xian Zhang, Abdolmohamad M Rostami
Peripheral tolerance to autoantigens is induced via suppression of self-reactive lymphocytes, stimulation of tolerogenic dendritic cells (DCs) and regulatory T (Treg) cells. Interleukin (IL)-27 induces tolerogenic DCs and Treg cells; however, it is not known whether IL-27 is important for tolerance induction. We immunized wild-type (WT) and IL-27 receptor (WSX-1) knockout mice with MOG35-55 for induction of experimental autoimmune encephalomyelitis and intravenously (i.v.) injected them with MOG35-55 after onset of disease to induce i...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29140433/il-27-il-27receptor-signaling-provides-protection-in-clostridium-difficile-induced-colitis
#14
Lifang Wang, Ju Cao, Congya Li, Zhang Liping
Background: Clostridium difficile is a leading cause of nosocomial infection. The role of cytokine IL-27 in the immunopathology of Clostridium difficile infection (CDI) remains unknown. Methods: The production of IL-27 was determined in human and murine CDI. Furthermore, wild-type (WT) and IL-27 receptor-deficient (WSX-1 -/-) mice were treated with an antibiotic mixture and infected with C.difficile to investigate the effects of IL-27 on host response to CDI. Results: IL-27 production was elevated during CDI in humans and mice...
November 11, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29118754/critical-role-of-plasmacytoid-dendritic-cells-in-regulating-gene-expression-and-innate-immune-responses-to-human-rhinovirus-16
#15
Yang Xi, Niamh M Troy, Denise Anderson, Olga M Pena, Jason P Lynch, Simon Phipps, Anthony Bosco, John W Upham
Though human rhinoviruses (HRVs) are usually innocuous viruses, they can trigger serious consequences in certain individuals, especially in the setting of impaired interferon (IFN) synthesis. Plasmacytoid dendritic cells (pDCs) are key IFN producing cells, though we know little about the role of pDC in HRV-induced immune responses. Herein, we used gene expression microarrays to examine HRV-activated peripheral blood mononuclear cells (PBMCs) from healthy people, in combination with pDC depletion, to assess whether observed gene expression patterns were pDC dependent...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29115624/decreased-expression-of-interleukin%C3%A2-37-and-its-anti%C3%A2-inflammatory-effect-in-allergic-rhinitis
#16
Yang Shen, Xia Ke, Liu Yun, Guo-Hua Hu, Hou-Yong Kang, Su-Ling Hong
Interleukin‑37 (IL‑37), a novel member of the IL‑1 cytokine family has been identified as a natural suppressor of innate immunity and inflammatory responses. The present study aimed to determine the expression of IL‑37 in peripheral blood mononuclear cells (PBMCs) from patients with allergic rhinitis (AR), and examine the possible immunosuppressive effect of IL‑37 on inflammatory mediators and CD4+ T cells in the pathogenesis of AR. The expression levels of IL‑37 were determined in PBMCs from 39 patients with AR and 43 controls using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis and flow cytometry...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29093268/microbiota-control-immune-regulation-in-humanized-mice
#17
Elke Gülden, Nalini K Vudattu, Songyan Deng, Paula Preston-Hurlburt, Mark Mamula, James C Reed, Sindhu Mohandas, Betsy C Herold, Richard Torres, Silvio M Vieira, Bentley Lim, Jose D Herazo-Maya, Martin Kriegel, Andrew L Goodman, Chris Cotsapas, Kevan C Herold
The microbiome affects development and activity of the immune system, and may modulate immune therapies, but there is little direct information about this control in vivo. We studied how the microbiome affects regulation of human immune cells in humanized mice. When humanized mice were treated with a cocktail of 4 antibiotics, there was an increase in the frequency of effector T cells in the gut wall, circulating levels of IFN-γ, and appearance of anti-nuclear antibodies. Teplizumab, a non-FcR-binding anti-CD3ε antibody, no longer delayed xenograft rejection...
November 2, 2017: JCI Insight
https://www.readbyqxmd.com/read/29093008/interleukin-27-exerts-its-antitumor-effects-by-promoting-differentiation-of-hematopoietic-stem-cells-to-m1-macrophages
#18
Yukino Chiba, Izuru Mizoguchi, Junichi Furusawa, Hideaki Hasegawa, Mio Ohashi, Mingli Xu, Toshiyuki Owaki, Takayuki Yoshimoto
The interleukin (IL)-27 promotes expansion and differentiation of hematopoietic stem cells into myeloid progenitor cells. Many tumor-infiltrating myeloid cells exert immunosuppressive effects but we hypothesized that the myeloid cells induced by IL-27 would have antitumor activity. In this study we corroborated this hypothesis as investigated in two distinct mouse transplantable tumor models. Malignant mouse cells engineered to express IL-27 exhibited reduced tumor growth in vivo. Correlated with this effect was a significant increase in the number of tumor-infiltrating CD11b+ myeloid cells exhibiting a reduced immunosuppressive activity...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29084365/views-of-dermatopathologists-about-clonality-assays-in-the-diagnosis-of-cutaneous-t-cell-and-b-cell-lymphoproliferative-disorders
#19
REVIEW
Nneka Comfere, Uma Sundram, M Yadira Hurley, Brian Swick
BACKGROUND: Appropriate use criteria have been developed for many tests using expert judgment, evidence-based practice, and clinical experience. In this context, the opinions of practitioners about clonality assays in various clinical scenarios where cutaneous lymphoma is suspected are reported. METHODS: An Appropriate Use Criteria Task Force sponsored by the American Society of Dermatopathology (ASDP) synthesized clinical scenarios for cutaneous lymphoproliferative disorders (LPD)...
October 30, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29074035/the-il-12-cytokine-family-in-cardiovascular-diseases
#20
T van der Heijden, I Bot, J Kuiper
Cytokines of the Interleukin (IL)-12 family, consisting of IL-12, IL-23, IL-27 and IL-35, are important regulators in (chronic) inflammatory disorders such as rheumatoid arthritis and multiple sclerosis, but also in cardiovascular diseases. Cytokines of the IL-12 family consist of two subunits and are known for their regulatory functions in the immunologic response, more specifically in the regulation and differentiation of T-helper (Th) cells such as Th1 and Th17 cells. Binding of these cytokines to its specific heterodimeric receptor results in the activation of the JAK-STAT signaling...
October 23, 2017: Cytokine
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