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IL-27

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https://www.readbyqxmd.com/read/29618655/il-27-gene-therapy-induces-depletion-of-tregs-and-enhances-the-efficacy-of-cancer-immunotherapy
#1
Jianmin Zhu, Jin-Qing Liu, Min Shi, Xinhua Cheng, Miao Ding, Jianchao C Zhang, Jonathan P Davis, Sanjay Varikuti, Abhay R Satoskar, Lanchun Lu, Xueliang Pan, Pan Zheng, Yang Liu, Xue-Feng Bai
Tumor-induced expansion of Tregs is a significant obstacle to cancer immunotherapy. However, traditional approaches to deplete Tregs are often inefficient, provoking autoimmunity. We show here that administration of IL-27-expressing recombinant adeno-associated virus (AAV-IL-27) significantly inhibits tumor growth and enhances T cell responses in tumors. Strikingly, we found that AAV-IL-27 treatment causes rapid depletion of Tregs in peripheral blood, lymphoid organs, and - most pronouncedly - tumor microenvironment...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29606863/cigarette-smoke-exposure-promotes-differentiation-of-cd4-t-cells-toward-th17-cells-by-cd40-cd40l-costimulatory-pathway-in-mice
#2
Yi Liang, Ying Shen, Liangjian Kuang, Guang Zhou, Longju Zhang, Xiaoning Zhong, Jianquan Zhang, Jifeng Liu
Purpose: This study aimed to investigate the impact of cigarette smoke exposure upon CD40-CD40L ligation between bone marrow-derived dendritic cells (BMDCs)and CD4+ T cells, and to examine the effects of cigarette smoke exposure upon differentiation of CD4+ T cells toward Th17 cells through blockade of CD40-CD40L pathway in mice. Methods: The study was processed in vivo and in vitro. In vivo, Th17 cells, CD40, interleukin (IL)-17A, and IL-27 in the lung tissues were quantified and compared between mice with and without cigarette smoke exposure...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29593047/il-27r-signalling-mediates-early-viral-containment-and-impacts-innate-and-adaptive-immunity-after-chronic-lymphocytic-choriomeningitis-virus-infection
#3
James A Harker, Kurt A Wong, Simone Dallari, Phuc Bao, Aleksandr Dolgoter, Yeara Jo, Ellen J Wehrens, Monica Macal, Elina I Zuniga
Chronic viral infections represent a major challenge to host's immune response and a unique network of immunological elements, including cytokines, are required for their containment. By using a model persistent infection with the natural murine pathogen lymphocytic choriomeningitis virus clone 13 (LCMV Cl13) we investigated the role of one such cytokine, interleukin 27 (IL-27), in the control of chronic infection. We found that IL-27R signalling promoted control of LCMV Cl13 as early as day 1 and 5 after infection and that il27p28 transcripts were rapidly elevated in multiple subsets of dendritic cells (DCs) and myeloid cells...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29580160/significant-transcriptome-and-cytokine-changes-in-hepatitis-b-vaccine-non-responders-revealed-by-genome-wide-comparative-analysis
#4
Shaohui Qiu, Peng He, Xin Fang, Haiqing Tong, Jingjing Lv, Jiaye Liu, Li Zhang, Xiangjun Zhai, Liying Wang, Zhongyu Hu, Yongli Yu
Individuals fail to elicit protective antibody after hepatitis B vaccination remain at risk for hepatitis B virus infection. Analysis of the transcriptome of peripheral blood mononuclear cells (PBMCs) is essential to elucidate the characteristics of gene expression in non-responders. In this study, we enrolled seven responders who had received three injections and seven non-responders who had six injections of hepatitis B vaccine before. All the participants were then vaccinated with a three-dose boost regimen...
March 26, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29565744/il-27-expression-and-responsiveness-in-human-uterine-epithelial-cells-and-fibroblasts-in-vitro-and-the-role-of-estradiol
#5
Mickey V Patel, Zheng Shen, Richard M Rossoll, Charles R Wira
Interleukin (IL)-27 is a pleiotropic cytokine that regulates multiple aspects of innate and adaptive immunity, but whose role in immune protection of the female reproductive tract is unknown. Although not constitutively expressed by human uterine epithelial cells and fibroblasts in culture, IL-27 secretion was upregulated after treatment with the viral ligand poly (I:C) in a type I interferon (IFN)-dependent manner, with higher levels measured in fibroblasts than epithelial cells. Estradiol increased poly (I:C)-induced IL-27 production by fibroblasts, but not epithelial cells...
March 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29549229/expression-of-igf-1-il-27-and-il-35-receptors-in-adjuvant-induced-rheumatoid-arthritis-model
#6
Elham Abdi, Hamid Najafipour, Siyavash Joukar, Shahriar Dabiri, Saeed Esmaeli-Mahani, Elham Abbasloo, Nasrin Houshmandi, Abbas Afsharipour
BACKGROUND: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. OBJECTIVE: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. METHODS: Freund's adjuvant-induced chronic joint inflammation was operated on 160 male rats. Animals were divided into histopathology and receptor expression groups, each composed of 10 subgroups including; control, vehicle, IGF-1, IL-27, IL-35, their antagonists, IGF-1+IL-27 antagonist and IGF-1+IL-35 antagonist...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29539604/diagnostic-accuracy-of-interleukin-27-between-tuberculous-pleural-effusion-and-malignant-pleural-effusion-a-meta-analysis
#7
Qing Liu, Yan-Xia Yu, Xiao-Juan Wang, Zheng Wang, Zhen Wang
BACKGROUND: The concentration assay of pleural effusion interleukin-27 (IL-27) has raised concern for diagnosing tuberculous pleurisy. Compared with malignant pleural effusion (MPE), the concentration of IL-27 in tuberculous pleural effusion (TPE) increased significantly. Accurate differentiating diagnosis is essential for choosing treatment for pleural effusion. OBJECTIVE: The present meta-analysis is aimed at determining the accuracy of IL-27 in the differential diagnosis between TPE and MPE...
March 14, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29527580/gene-array-analysis-of-pd-1h-overexpressing-monocytes-reveals-a-pro-inflammatory-profile
#8
Preeti Bharaj, Chunting Ye, Sean Petersen, Qianghu Wang, Baoli Hu, N Manjunath, Premlata Shankar, Guohua Yi
We have previously reported that overexpression of Programmed Death -1 Homolog (PD-1H) in human monocytes leads to activation and spontaneous secretion of multiple pro inflammatory cytokines. Here we evaluate changes in monocytes gene expression after enforced PD-1H expression by gene array. The results show that there are significant alterations in 51 potential candidate genes that relate to immune response, cell adhesion and metabolism. Genes corresponding to pro-inflammatory cytokines showed the highest upregulation, 7, 3...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29522694/chickpea-supplementation-prior-to-colitis-onset-reduces-inflammation-in-dextran-sodium-sulfate-treated-c57bl-6-male-mice
#9
Jennifer M Monk, Wenqing Wu, Laurel H McGillis, Hannah R Wellings, Amber L Hutchinson, Danyelle M Liddle, Daniela Graf, Lindsay E Robinson, Krista A Power
The potential for a chickpea supplemented diet (rich in fermentable non-digestible carbohydrates and phenolic compounds) to modify the colonic microenvironment and attenuate the severity of acute colonic inflammation was investigated. C57Bl/6 male mice were fed a control basal diet (BD) or BD supplemented with 20% cooked chickpea flour for 3 weeks prior to acute colitis onset induced by 7-day exposure to dextran sodium sulfate (DSS, 2% w/v in drinking water) and colon and serum levels of inflammatory mediators were assessed...
March 9, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29508072/induction-of-pir-a-b-dcs-in-the-in-vitro-inflammatory-condition-and-their-immunoregulatory-function
#10
Fumi Matsui, Muneo Inaba, Kazushige Uchida, Akiyoshi Nishio, Toshiro Fukui, Hideaki Yoshimura, Atsushi Satake, Kazuhiko Yoshioka, Shosaku Nomura, Kazuichi Okazaki
BACKGROUND: Dendritic cells (DCs), primary antigen-presenting cells, are now well known as an immunoregulator of many aspects of immune responses including inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis. We have reported that PIR-A/Bhigh cDCs (conventional DCs) appeared in dextran sodium sulfate (DSS)-induced colitis and serve as a negative immunoregulator in an animal model of IBD. The immunoregulatory role of PIR-A/B+ cDCs was confirmed in both an in vitro culture system and an in vivo transfer experiment...
March 5, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29507906/interleukins-17-and-27-promote-liver-regeneration-by-sequentially-inducing-progenitor-cell-expansion-and-differentiation
#11
Adrien Guillot, Imène Gasmi, Arthur Brouillet, Yeni Ait-Ahmed, Julien Calderaro, Isaac Ruiz, Bin Gao, Sophie Lotersztajn, Jean-Michel Pawlotsky, Fouad Lafdil
Liver progenitor cells (LPCs)/ductular reactions (DRs) are associated with inflammation and implicated in the pathogenesis of chronic liver diseases. However, how inflammation regulates LPCs/DRs remains largely unknown. Identification of inflammatory processes that involve LPC activation and expansion represent a key step in understanding the pathogenesis of liver diseases. In the current study, we found that diverse types of chronic liver diseases are associated with elevation of infiltrated interleukin (IL)-17-positive (+) cells and cytokeratin 19 (CK19)+ LPCs, and both cell types colocalized and their numbers positively correlated with each other...
March 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29503739/regulation-of-osteoclast-differentiation-by-cytokine-networks
#12
REVIEW
Dulshara Sachini Amarasekara, Hyeongseok Yun, Sumi Kim, Nari Lee, Hyunjong Kim, Jaerang Rho
Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand play a central role in OC differentiation, which is also termed osteoclastogenesis. Osteoclastogenic cytokines, including tumor necrosis factor-α, IL-1, IL-6, IL-7, IL-8, IL-11, IL-15, IL-17, IL-23, and IL-34, promote OC differentiation, whereas anti-osteoclastogenic cytokines, including interferon (IFN)-α, IFN-β, IFN-γ, IL-3, IL-4, IL-10, IL-12, IL-27, and IL-33, downregulate OC differentiation...
February 2018: Immune Network
https://www.readbyqxmd.com/read/29500240/murine-%C3%AE-herpesvirus-68-induces-severe-lung-inflammation-in-il-27-deficient-mice-with-liver-dysfunction-preventable-by-oral-neomycin
#13
Kyosuke Kanai, Ah-Mee Park, Akiko Watanabe, Tomohiro Arikawa, Teruhito Yasui, Hiroki Yoshida, Ikuo Tsunoda, Osamu Yoshie
IL-27 is an immunoregulatory cytokine consisting of p28 and EBI3. Its receptor also has two subunits, WSX1 and gp130. Although IL-27 promotes Th1 differentiation in naive T cells, it also induces IL-10 expression in effector Th1 cells to curtail excessive immune responses. By using p28-deficient mice and WSX1-deficient mice (collectively called IL-27-deficient mice), we examined the role of IL-27 in primary infection by murine γ-herpesvirus 68 (MHV68), a murine model of EBV. Upon airway infection with MHV68, IL-27-deficient mice had more aggravated lung inflammation than wild-type mice, although MHV68 infection per se was better controlled in IL-27-deficient mice...
March 2, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29497424/interleukin-il-6-inhibits-il-27-and-il-30-mediated-inflammatory-responses-in-human-monocytes
#14
Carlene Petes, Mélissa K Mariani, Yawen Yang, Nathalie Grandvaux, Katrina Gee
Interleukin (IL)-30, the IL-27p28 subunit of the heterodimeric cytokine IL-27, acts as an antagonist of IL-27 and IL-6 signaling in murine cells via glycoprotein 130 (gp130) receptor and additional binding partners. Thus far, functions of IL-30 have not been fully elucidated in human cells. We demonstrate that like IL-27, IL-30 upregulated TLR4 expression to enhance lipopolysaccharide-induced TNF-α production in human monocytes; however, these IL-30-mediated activities did not reach the same levels of cytokine induction compared to IL-27...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29494633/a-spontaneous-model-of-spondyloarthropathies-that-develops-bone-loss-and-pathological-bone-formation-a-process-regulated-by-il27ra-and-mutant-p53
#15
Denada Dibra, Xueqing Xia, Mihai Gagea, Guillermina Lozano, Shulin Li
Spondyloarthropathies, the second most frequently occurring form of chronic inflammatory arthritis, affects young adults in particular. However, a proper model with which to study the biology of this disease and to develop therapeutics is lacking. One of the most accepted animal models for this disease uses HLA-B27/Hu-β2m transgenic rats; however, only 30%-50% of male HLA-B27/Hu-β2m rats develop spontaneous, clinically apparent spondylitis and have a variable time until disease onset. Here, we report a high-incidence, low-variation spontaneous mouse model that delineates how the combination of inflammatory cytokine interleukin-27 (IL-27) signaling deficiency and mitogenic signaling (mutant p53R172H) in vivo, leads to bone loss in the vertebral bodies and ossification of the cartilage in the intervertebral discs...
2018: PloS One
https://www.readbyqxmd.com/read/29437229/il-27-a-double-agent-in-the-il-6-family
#16
REVIEW
Gareth W Jones, David G Hill, Anna Cardus Figueras, Simon A Jones
The cytokine interleukin (IL)-6 is a major therapeutic target for the treatment of various inflammatory and autoimmune diseases. While IL-6 receives considerable attention in studies of innate and adaptive immunity, the IL-6-related family member IL-27 is increasingly recognized for its effects on cellular proliferation, differentiation and leukocyte effector functions. Both cytokines activate responses in myeloid and stromal tissue cells where they direct the transition from innate to adaptive immunity. However, they are frequently identified as lymphokines that control responses in T cells and B cells...
February 13, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29434217/il-23-and-il-27-levels-in-serum-are-associated-with-the-process-and-the-recovery-of-guillain-barr%C3%A3-syndrome
#17
Jing Peng, Hui Zhang, Peidong Liu, Min Chen, Bing Xue, Rui Wang, Jifei Shou, Juanfeng Qian, Zhikang Zhao, Yanmeng Xing, Hongbo Liu
IL-23 and IL-27 are believed to be involved in the pathogenesis of Guillain-Barré syndrome (GBS). However, changes in these cytokines during the dynamic pathological and recovery processes of GBS are not well described. In the present study, plasma was collected from 83 patients with various stages of GBS, 70 patients with central nervous system demyelinating diseases,70 patients with other neurological diseases (OND) and 70 age- and sex-matched healthy volunteers. Serum levels of IL-23, IL-27, and Campylobacter jejuni (CJ) IgM were assessed using enzyme linked immunosorbent assay (ELISA)...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29428559/elevated-il-27-in-patients-with-acute-coronary-syndrome-is-associated-with-adverse-ventricular-remodeling-and-increased-risk-of-recurrent-myocardial-infarction-and-cardiovascular-death
#18
Helena Grufman, Troels Yndigegn, Isabel Gonçalves, Jan Nilsson, Alexandru Schiopu
BACKGROUND AND AIMS: IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group. METHODS: We included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA). A subgroup of 107 patients donated blood samples 6 weeks after the index event, and underwent a follow-up echocardiographical examination at 1 year...
February 7, 2018: Cytokine
https://www.readbyqxmd.com/read/29408778/increased-serum-levels-of-tnf-%C3%AE-and-decreased-serum-levels-of-il-27-in-patients-with-parkinson-disease-and-their-correlation-with-disease-severity
#19
Ebrahim Kouchaki, Reza Daneshvar Kakhaki, Omid Reza Tamtaji, Ehsan Dadgostar, Mohammad Behnam, Hassan Nikoueinejad, Hossein Akbari
OBJECTIVES: Immunological basis of neurodegenerative diseases including Alzheimer and Parkinson disease (PD) has some important roles in their pathogenesis. There are conflicting studies to serum level of TNF-α in PD. Also, according to our finding there is no report evaluating serum level of IL-27 in PD. This study correlates the serum level of those factors with severity of PD. PATIENTS AND METHODS: In this case-control study, 83 patients with PD and 83 healthy volunteers were enrolled...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29399137/diagnostic-value-of-t-spot-tb-combined-with-inf-%C3%AE-and-il-27-in-tuberculous-pleurisy
#20
Meng Zhang, Dedong Xiong, Hongxia Li, Zonglan Wang, Renzhe Li
The purpose of the present study was to investigate the diagnostic value of T cells spot test (T-Spot TB) combined with interferon-γ (INF-γ) and interleukin-27 (IL-27) in tuberculous pleurisy. Sixty patients with tuberculous pleurisy (observation group) and 60 patients with non-tuberculous pleurisy (control group) were enrolled in this study. T-Spot TB was performed to detect the pleural effusion of two groups of patients. Levels of IFN-γ and IL-27 in serum and pleural effusion were detected by enzyme-linked immunosorbent assay (ELISA)...
February 2018: Experimental and Therapeutic Medicine
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