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IL-27

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https://www.readbyqxmd.com/read/28069403/functional-variant-in-the-promoter-region-of-il-27-alters-gene-transcription-and-confers-a-risk-for-ulcerative-colitis-in-northern-chinese-han
#1
Wei Yu, Kun Zhang, Zhongyi Wang, Jiayu Zhang, Tong Chen, Lifang Jin
Ulcerative colitis (UC) is a chronic inflammatory disorder of unknown etiology and a polygenic disease. IL-27 encodes p28, a subunit of IL-12 family cytokines, and has been implicated in the pathogenesis of UC. The aims of the present study were to evaluate the genetic association of a variant of the IL-27 gene with UC and to further characterize the functional variant in the IL-27 gene that influences the risk for UC. Our data demonstrated that the genetic variant rs153109 in the 5' upstream region of IL-27 is significantly associated with UC in Chinese Han individuals...
January 6, 2017: Human Immunology
https://www.readbyqxmd.com/read/28062696/prostaglandin-e2-inhibition-of-il-27-production-in-murine-dendritic-cells-a-novel-mechanism-that-involves-irf1
#2
Kirsten M Hooper, Jui-Hung Yen, Weimin Kong, Kate M Rahbari, Ping-Chang Kuo, Ana M Gamero, Doina Ganea
IL-27, a multifunctional cytokine produced by APCs, antagonizes inflammation by affecting conventional dendritic cells (cDC), inducing IL-10, and promoting development of regulatory Tr1 cells. Although the mechanisms involved in IL-27 induction are well studied, much less is known about the factors that negatively impact IL-27 expression. PGE2, a major immunomodulatory prostanoid, acts as a proinflammatory agent in several models of inflammatory/autoimmune disease, promoting primarily Th17 development and function...
January 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28058287/impact-of-il-27-on-hepatocyte-antiviral-gene-expression-and-function
#3
Narayan Ramamurthy, Sara Boninsegna, Rebecca Adams, Natasha Sahgal, Helen Lockstone, Dilair Baban, Emanuele Marchi, Paul Klenerman
Background: Interleukin (IL)-27 is a member of the IL-6/IL-12 family of cytokines. It is a potent cytokine, with potential antiviral impact, and has been shown to play a role in modulating functions of diverse cell types, including Th1, Th2, and NK and B cells, demonstrating both pro- and anti-inflammatory roles.  In hepatocytes, it is capable of inducing signal transducer and activator of transcription (STAT)1, STAT3 and interferon-stimulated genes. Methods: To address its role in viral hepatitis, the antiviral activity of IL-27 against hepatitis C virus (HCV) and hepatitis B virus (HBV) was tested in vitro using cell-culture-derived infectious HCV (HCVcc) cell culture system and the HepaRG HBV cell culture model...
November 17, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28055231/effect-of-interleukin-27-genetic-variants-on-atrial-fibrillation-susceptibility
#4
Yu Chen, Jianhui Zeng, Rui Zhang, Linjun Zeng, Yajiao Li, Hong Wei, Qing Yang
AIM: Atrial fibrillation (AF) is the most common cardiac arrhythmia. No data are available on the association between the polymorphisms of interleukin-27 (IL-27) and AF in the Chinese Han population. This study was performed to determine if polymorphisms within the IL-27 gene are involved in the AF susceptibility. METHODS: Two hundred seventy AF patients and 303 healthy individuals were examined for two IL-27 gene polymorphisms (rs153109 and rs17855750) by polymerase chain reaction-restriction fragment length polymorphism methodology...
January 5, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28027499/imbalance-between-the-anti-and-pro-inflammatory-milieu-in-blood-leukocytes-of-autistic-children
#5
Sheikh F Ahmad, Ahmed Nadeem, Mushtaq A Ansari, Saleh A Bakheet, Sabry M Attia, Khairy M A Zoheir, Laila Yousef Al-Ayadhi, Mohammad Z Alzahrani, Abdulaziz M S Alsaad, Moureq R Alotaibi, Adel R A Abd-Allah
Accumulating evidence suggests an association between immune dysfunction and autism disorders in a significant subset of children. In addition, an imbalance between pro- and anti-inflammatory pathways has been proposed to play an important role in the pathogenesis of several neurodevelopmental disorders including autism; however, the role of anti-inflammatory molecules IL-27 and CTLA-4 and pro-inflammatory cytokines IL-21 and IL-22 has not previously been explored in autistic children. In the current study, we investigated the expression of IL-21, IL-22, IL-27, and CD152 (CTLA-4) following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMCs) from children with autism (AU) or typically-developing children (TD) with phorbol-12-myristate 13-acetate (PMA) and ionomycin...
December 24, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27994590/cigarette-smoke-induction-of-interleukin-27-wsx-1-regulates-the-differentiation-of-th1-and-th17-cells-in-a-smoking-mouse-model-of-emphysema
#6
Shi-Lin Qiu, Min-Chao Duan, Yi Liang, Hai-Juan Tang, Guang-Nan Liu, Liang-Ming Zhang, Chao-Mian Yang
IFN-γ-producing CD4(+) T (Th1) cells and IL-17-producing CD4(+) T (Th17) cells play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the immune regulation between Th1 and Th17 cells remains unclear. Previous studies have demonstrated that interleukin-27 (IL-27)/WSX-1 exerted pro- or anti-inflammatory effects in many acute inflammatory diseases by modulating T cell-mediated immune response, but little was known about its role in chronic inflammatory disease, especially in smoking-related lung diseases...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27992577/tolerogenic-plasmacytoid-dendritic-cells-control-paracoccidioides-brasiliensis-infection-by-inducting-regulatory-t-cells-in-an-ido-dependent-manner
#7
Eliseu Frank de Araújo, Daniella Helena Medeiros, Nayane Alves de Lima Galdino, Antônio Condino-Neto, Vera Lúcia Garcia Calich, Flávio Vieira Loures
Plasmacytoid dendritic cells (pDCs), considered critical for immunity against viruses, were recently associated with defense mechanisms against fungal infections. However, the immunomodulatory function of pDCs in pulmonary paracoccidiodomycosis (PCM), an endemic fungal infection of Latin America, has been poorly defined. Here, we investigated the role of pDCs in the pathogenesis of PCM caused by the infection of 129Sv mice with 1 x 106 P. brasiliensis-yeasts. In vitro experiments showed that P. brasiliensis infection induces the maturation of pDCs and elevated synthesis of TNF-α and IFN-β...
December 19, 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27939414/decreased-expression-of-il-27-in-moderate-to-severe-psoriasis-and-its-anti-inflammation-role-in-imiquimod-induced-psoriasis-like-mouse-model
#8
Wenjuan Chen, Yu Gong, Xilin Zhang, Yunlei Tong, Xiuxiu Wang, Chengwen Fei, Hui Xu, Qian Yu, Yao Wang, Yuling Shi
BACKGROUND: Psoriasis is a high-incident T-cell-mediated autoimmune disease mainly affecting the skin. Interleukin (IL)-27 is a novel member of the IL-6/IL-12 cytokine family, which plays a versatile role in the differentiation and function of distinct T cell subsets. Previous studies uncovered that IL-27 promoted the onset of psoriasis through enhancing the differentiation of T helper (Th) 1 cells. However, the role of IL-27 in other psoriasis-related Th lineages, especially Th17 cells, remains elusive...
February 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27929666/association-between-il-27-gene-polymorphisms-and-risk-of-papillary-thyroid-carcinoma
#9
Xinwen Nie, Fang Yuan, Peng Chen, Yan Pu, Jingqiang Zhu, Yichao Wang, Xue Xiao, Guanglu Che, Linbo Gao, Lin Zhang
AIM: IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in IL-27 to the risk of papillary thyroid carcinoma (PTC). MATERIALS & METHODS:  IL-27 rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: The rs153109 AG and AG/GG genotypes were significantly associated with increased risks for PTC...
December 8, 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27926930/cytomegalovirus-specific-il-10-producing-cd4-t-cells-are-governed-by-type-i-ifn-induced-il-27-and-promote-virus-persistence
#10
Mathew Clement, Morgan Marsden, Maria A Stacey, Juneid Abdul-Karim, Silvia Gimeno Brias, Diana Costa Bento, Martin J Scurr, Peter Ghazal, Casey T Weaver, Gianluca Carlesso, Simon Clare, Simon A Jones, Andrew Godkin, Gareth W Jones, Ian R Humphreys
CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts infected with the β-herpesviridae human cytomegalovirus (HCMV) or murine cytomegalovirus (MCMV) express the regulatory cytokine interleukin (IL)-10. IL-10+CD4+ T cells co-expressed TH1-associated transcription factors and chemokine receptors. Mice lacking T cell-derived IL-10 elicited enhanced antiviral T cell responses and restricted MCMV persistence in salivary glands and secretion in saliva...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27886396/5-ala-mediated-photodynamic-therapy-reduces-the-parasite-load-in-mice-infected-with-leishmania-braziliensis
#11
Danila Malheiros Souza, Polyanna Miranda Alves, Mona Lisa Fabiana Silva, Tony Paiva Paulino, Henrique Ovidio Coraspe, Mônica Miguel Sawan Mendonça, Betânia Maria Ribeiro, Marcos Vinicius da Silva, Virmondes Rodrigues Júnior, Denise Bertulucci Rocha Rodrigues
INTRODUCTION: Photodynamic therapy (PDT) has proven to be an effective alternative for the treatment of cutaneous leishmaniasis. Skin lesions consist of ulcers with well-defined raised edges, and granular floor. Th1 immune response is the protective profile in patients infected with Leishmania. In the present study, the photodynamic therapy with 5-aminolevulinic acid, the parasitic load, and the modulation of the immune response were evaluated in mice infected with Leishmania braziliensis...
November 25, 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27881708/il-35-suppresses-lipopolysaccharide-induced-airway-eosinophilia-in-ebi3-deficient-mice
#12
Kyosuke Kanai, Ah-Mee Park, Hiroki Yoshida, Ikuo Tsunoda, Osamu Yoshie
EBI3 functions as the subunit of immune-regulatory cytokines, such as IL-27 and IL-35, by pairing with p28 and p35, respectively. We treated wild-type and EBI3-deficient mice with intratracheal administration of LPS and obtained bronchoalveolar lavage fluid (BALF) 24 h later. Although neutrophils were the predominant cells in BALF from both groups of mice, eosinophils were highly enriched and there was increased production of eosinophil-attracting chemokines CCL11 and CCL24 in BALF of EBI3-deficient mice. The bronchial epithelial cells and alveolar macrophages were the major producers of CCL11 and CCL24...
January 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27878721/evaluation-in-vitro-of-immunoregulatory-cytokines-secretion-by-dendritic-cells-in-mountain-skiers
#13
V S Evstratova, D B Nikityuk, N A Riger, N V Fedyanina, R A Khanferyan
In vitro production of immunoregulatory cytokines (IFN-α, IL-31, TNF-β, IL-17A, IL-7, IL-1RA, IL-1α, IL-10, IL-15, IL-21, IL-22, IL-23, IL-27, and IL-9) by dendritic cell cultures was compared in ski athletes and healthy donors. Effect of prolonged intense physical exercise on secretory activity of immune cells was investigated. In both groups, secretion of IL-1RA, IL-10, IL-1α by dendritic cells was revealed, but there were significant differences in IL-1RA, IL-1α content (p<0.05) with lower level in the group of athletes...
November 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27871325/impact-of-placental-plasmodium-falciparum-malaria-infection-on-the-cameroonian-maternal-and-neonate-s-plasma-levels-of-some-cytokines-known-to-regulate-t-cells-differentiation-and-function
#14
Jean Claude Djontu, Stalone Siewe Siewe, Yolande Delphine Mpeke Edene, Benderli Christine Nana, Edwige Vanessa Chomga Foko, Jude Daiga Bigoga, Rose F G Leke, Rosette Megnekou
BACKGROUND: The impact of placental malaria (PM) infection on the expression profile of some cytokines known to regulate T cell differentiation and function and their influence on birth weight remain unclear. Moreover, there are no reports showing the relationship between PM and IL-27 or IL-28A. This study therefore sought to investigate whether placental P. falciparum infection alters the expression profile of the cytokines IL-28A, IL-27, IL-17E and IL-6 in mothers and their new born...
November 21, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27869736/circulating-il-27-is-elevated-in-rheumatoid-arthritis-patients
#15
Xiaofei Lai, Hongxu Wang, Ju Cao, Ying Li, Yubing Dai, Yu Xiang, Liping Zhang
Cytokines are key immunoregulatory molecules that regulate T lymphocyte-mediated immune responses and inflammatory reactions. We determined whether there is aberrant expression of interleukin-27 (IL-27) in rheumatoid arthritis (RA) patients and investigated the clinical significance of these changes. IL-27 is a key cellular factor that regulates the differentiation of CD4+ T cells, which can secrete interleukin-10 (IL-10) and interleukin-17 (IL-17) in vivo. Concentrations of serum IL-27 in 67 RA patients, and 36 sex- and age-matched control subjects were measured by enzyme-linked immunosorbent assay (ELISA)...
November 18, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27867385/expanding-diversity-in-molecular-structures-and-functions-of-the-il-6-il-12-heterodimeric-cytokine-family
#16
REVIEW
Hideaki Hasegawa, Izuru Mizoguchi, Yukino Chiba, Mio Ohashi, Mingli Xu, Takayuki Yoshimoto
The interleukin (IL)-6/IL-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. This cytokine family has very unique characteristics in that they comprise two distinct subunits forming a heterodimer and each cytokine and receptor subunit shares with each other. The members of this cytokine family are increasing; currently, there are more than six cytokines, including the tentatively named cytokines IL-Y (p28/p40), IL-12 (p35/p40), IL-23 (p19/p40), IL-27 [p28/Epstein-Barr virus-induced protein 3 (EBI3)], IL-35 (p35/EBI3), and IL-39 (p19/EBI3)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27867384/interleukin-27-early-impacts-leishmania-infantum-infection-in-mice-and-correlates-with-active-visceral-disease-in-humans
#17
Begoña Pérez-Cabezas, Pedro Cecílio, Ana Luisa Robalo, Ricardo Silvestre, Eugenia Carrillo, Javier Moreno, Juan V San Martín, Rita Vasconcellos, Anabela Cordeiro-da-Silva
The complexity of Leishmania-host interactions, one of the main leishmaniasis issues, is yet to be fully understood. We detected elevated IL-27 plasma levels in European patients with active visceral disease caused by Leishmania infantum, which returned to basal levels after successful treatment, suggesting this cytokine as a probable infection mediator. We further addressed this hypothesis recurring to two classical susceptible visceral leishmaniasis mouse models. BALB/c, but not C57BL/6 mice, showed increased IL-27 systemic levels after infection, which was associated with an upregulation of IL-27p28 expression by dendritic cells and higher parasite burdens...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27834348/erratum-thymic-dcs-derived-il-27-regulates-the-final-maturation-of-cd4-sp-thymocytes
#18
Hui Tang, Jie Zhang, Xiuyuan Sun, Xiaoping Qian, Yu Zhang, Rong Jin
No abstract text is available yet for this article.
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27829708/interleukin-22-might-act-as-a-double-edged-sword-in-type-2-diabetes-and-coronary-artery-disease
#19
Fangchen Gong, Jin Wu, Ping Zhou, Mengyao Zhang, Jingning Liu, Ying Liu, Xiang Lu, Zhengxia Liu
Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are both characterized by chronic low-grade inflammation. The role of Th17 and its related cytokines in T2DM and CAD is unclear. Here we investigated the serum levels of five Th17-related cytokines (IL-17, IL-22, MIP-3α, IL-9, and IL-27) in T2DM, CAD, and T2DM-CAD comorbidity patients. IL-22 was found to be elevated in all three conditions. Elevated serum IL-22 was independently associated with the incidence of T2DM and CAD. Conversely, IL-22 was found to protect endothelial cells from glucose- and lysophosphatidylcholine- (LPC-) induced injury, and IL-22R1 expression on endothelial cells was increased upon treatment with high glucose and LPC...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27799933/ectopic-lymphoid-structures-powerhouse-of-autoimmunity
#20
REVIEW
Elisa Corsiero, Alessandra Nerviani, Michele Bombardieri, Costantino Pitzalis
Ectopic lymphoid structures (ELS) often develop at sites of inflammation in target tissues of autoimmune diseases, such as rheumatoid arthritis, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, and systemic lupus erythematosus. ELS are characterized by the formation of organized T/B cells aggregates, which can acquire follicular dendritic cells network supporting an ectopic germinal center response. In this review, we shall summarize the mechanisms that regulate the formation of ELS in tertiary lymphoid organs, with particular emphasis on the role of lymphoid chemokines in both formation and maintenance of ELS, the role of emerging positive and negative regulators of ELS development and function, including T follicular helper cells and IL-27, respectively...
2016: Frontiers in Immunology
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