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https://www.readbyqxmd.com/read/29033934/ebi3-prevents-trypanosoma-cruzi-induced-myocarditis-by-dampening-ifn-%C3%AE-driven-inflammation
#1
Tiago Silva Medina, Gabriela Gonçalves Oliveira, Maria Cláudia Silva, Bruna Araújo David, Grace Kelly Silva, Denise Morais Fonseca, Renata Sesti-Costa, Amanda Farage Frade, Monique Andrade Baron, Barbara Ianni, Alexandre Costa Pereira, Christophe Chevillard, Edécio Cunha-Neto, José Antonio Marin-Neto, João Santana Silva
The identification of anti-inflammatory mediators can reveal important targetable molecules capable of counterbalancing Trypanosoma cruzi-induced myocarditis. Composed of Ebi3 and IL-27p28 subunits, IL-27 is produced by myeloid cells and is able to suppress inflammation by inducing IL-10-producing Tr1 cells, thus emerging as a potential candidate to ameliorate cardiac inflammation induced by T. cruzi. Although IL-27 has been extensively characterized as a suppressive cytokine that prevents liver immunopathogenesis after T...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29021521/tristetraprolin-inhibits-macrophage-il-27-induced-activation-of-antitumour-cytotoxic-t-cell-responses
#2
Qinghong Wang, Huan Ning, Hui Peng, Lin Wei, Rong Hou, Daniel F Hoft, Jianguo Liu
IFN-γ-producing cytotoxic T lymphocytes are essential for host defense against viral infection and cancer. Here we show that the RNA-binding tristetraprolin, encoded by Zfp36, is needed for CD8(+) T-cell production of IFN-γ in vivo. When activated in vitro, however, IFN-γ production by naive wild type and tristetraprolin-deficient CD8(+) T-cells is comparable. IL-27 is overproduced by tristetraprolin-deficient macrophages and increased systemically in tristetraprolin-deficient mice. Tristetraprolin suppresses IL-27 production by promoting p28 mRNA degradation...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29020964/il-27-mediates-hla-class-i-up-regulation-which-can-be-inhibited-by-the-il-6-pathway-in-hla-deficient-small-cell-lung-cancer-cells
#3
Grazia Carbotti, Amin Reza Nikpoor, Paola Vacca, Rosaria Gangemi, Chiara Giordano, Francesco Campelli, Silvano Ferrini, Marina Fabbi
BACKGROUND: Recently, immunotherapy with anti-PD-1 antibodies has shown clinical benefit in recurrent Small Cell Lung Cancer (SCLC). Since anti-PD-1 re-activates anti-tumor Cytotoxic T Lymphocyte (CTL) responses, it is crucial to understand the mechanisms regulating HLA class I, and PD-L1 expression in HLA-negative SCLC. Here we addressed the role of IL-27, a cytokine related to both IL-6 and IL-12 families. METHODS: The human SCLC cell lines NCI-N592, -H69, -H146, -H446 and -H82 were treated in vitro with different cytokines (IL-27, IFN-γ, IL-6 or a soluble IL-6R/IL-6 chimera [sIL-6R/IL-6]) at different time points and analyzed for tyrosine-phosphorylated STAT proteins by Western blot, for surface molecule expression by immunofluorescence and FACS analyses or for specific mRNA expression by QRT-PCR...
October 11, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29019857/interleukin-27-is-a-potential-rescue-therapy-for-acute-severe-colitis-through-interleukin-10-dependent-t-cell-independent-attenuation-of-colonic-mucosal-innate-immune-responses
#4
Mairi H McLean, Caroline Andrews, Miranda L Hanson, Walter A Baseler, Miriam R Anver, Emilee Senkevitch, Aleksandra K Staniszewska, Christopher Smith, Luke C Davies, Julie Hixon, Wenqeng Li, Wei Shen, Lothar Steidler, Scott K Durum
BACKGROUND: If treatment with intravenous steroids fail, inflammatory bowel disease patients with acute severe colitis face systemic anti-tumor necrosis factor biologic rescue therapy or colectomy. Interleukin (IL)-27 is a cytokine with an immunosuppressive role in adaptive immune responses. However, the IL-27 receptor complex is also expressed on innate immune cells, and there is evidence that IL-27 can impact the function of innate cell subsets, although this particular functionality in vivo is not understood...
November 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28993775/il-27-induced-type-1-regulatory-t-cells-produce-oxysterols-that-constrain-il-10-production
#5
Solenne Vigne, Fanny Chalmin, Donovan Duc, Aurélie S Clottu, Lionel Apetoh, Jean-Marc A Lobaccaro, Isabelle Christen, Juan Zhang, Caroline Pot
The behaviors of lymphocytes, including CD4(+) T helper cells, are controlled on many levels by internal metabolic properties. Lipid metabolites have recently been ascribed a novel function as immune response modulators and perturbation of steroids pathways modulates inflammation and potentially promotes a variety of diseases. However, the impact of lipid metabolism on autoimmune disease development and lymphocyte biology is still largely unraveled. In this line, oxysterols, oxidized forms of cholesterol, have pleiotropic roles on the immune response aside from their involvements in lipid metabolism...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28985996/tlr-induced-secretion-of-novel-cytokine-il-27-is-defective-in-newly-diagnosed-type-2-diabetic-subjects
#6
Haridoss Madhumitha, Viswanathan Mohan, Subash Babu, Vivekanandhan Aravindhan
Toll-like receptors (TLRs), the innate immune receptors, act as sentinels bridging both innate and adaptive arms of immunity. In the present study, we estimated TLR-induced secretion of IL-27, IL-12, IL-23, IL-8, IP-10, IL-17, IL-6 and TNF-α (by ELISA) and expression of Human Leukocyte Antigen- (Human Leukocyte Antigen - antigen D Related (HLA-DR), CD69, CD80 (also known asB7-1) (by flowcytometry) and Activating Transcription Factor 3(ATF3) (by qRT-PCR) in whole blood cultures of control and type-2 diabetic (both newly diagnosed/NDD and known/KDM) subjects...
October 3, 2017: Cytokine
https://www.readbyqxmd.com/read/28977795/il-27-modulates-chemokine-production-in-tnf-%C3%AE-stimulated-human-oral-epithelial-cells
#7
Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Takashi Matsuo
BACKGROUND/AIMS: Interleukin-27 (IL-27) is a cytokine which belongs to the IL-12 family. However, the role of IL-27 in the pathogenesis of periodontal disease is uncertain. The aim of this study was to examine the effect of IL-27 on chemokine production in TNF-α-stimulated human oral epithelial cells (TR146). METHODS: We measured chemokine production in TR146 by ELISA. We used western blot analysis to detect the phosphorylation levels of signal transduction molecules, including STAT1 and STAT3 in TR146...
October 5, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28969616/assessment-of-biomarkers-using-multiplex-assays-in-aqueous-humor-of-patients-with-diabetic-retinopathy
#8
Hui Chen, Xiongze Zhang, Nanying Liao, Feng Wen
BACKGROUND: With the high prevalence of type 2 diabetes, diabetic retinopathy (DR) has become a leading health problem worldwide. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. The purpose of this study was to assess the levels of immune and inflammatory biomarkers in the aqueous humor of patients with different severities of DR and to analyze the correlations between Interleukin-6 (IL-6) and these biomarkers, and between IL-6 and the severity of the disease...
October 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28953978/early-il-6-signalling-promotes-il-27-dependent-maturation-of-regulatory-t-cells-in-the-lungs-and-resolution-of-viral-immunopathology
#9
Chloe J Pyle, Faith I Uwadiae, David P Swieboda, James A Harker
Interleukin-6 is a pleiotropic, pro-inflammatory cytokine that can promote both innate and adaptive immune responses. In humans with respiratory virus infections, such as Respiratory Syncytial Virus (RSV), elevated concentrations of IL-6 are associated with more severe disease. In contrast the polymorphisms in the Il6 promoter which favour lower IL-6 production are associated with increased risk of both RSV and Rhinovirus infections. To determine the precise contribution of IL-6 to protection and pathology we used murine models of respiratory virus infection...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28936213/interferon-gamma-in-african-trypanosome-infections-friends-or-foes
#10
REVIEW
Hui Wu, Gongguan Liu, Meiqing Shi
African trypanosomes cause fatal infections in both humans and livestock. Interferon gamma (IFN-γ) plays an essential role in resistance to African trypanosomes. However, increasing evidence suggests that IFN-γ, when excessively synthesized, also induces immunopathology, enhancing susceptibility to the infection. Thus, production of IFN-γ must be tightly regulated during infections with African trypanosomes to ensure that a robust immune response is elicited without tissue destruction. Early studies have shown that secretion of IFN-γ is downregulated by interleukin 10 (IL-10)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28935468/function-and-regulation-of-lag3-on-cd4-cd25-t-cells-in-non-small-cell-lung-cancer
#11
Qin-Yun Ma, Da-Yu Huang, Hui-Jun Zhang, Shaohua Wang, Xiao-Feng Chen
LAG3 is a surface molecule found on a subset of immune cells. The precise function of LAG3 appears to be context-dependent. In this study, we investigated the effect of LAG3 on CD4(+)CD25(-) T cells from non-small cell lung cancer (NSCLC) patients. We found that in the peripheral blood mononuclear cells of NSCLC patients, LAG3 was significantly increased in CD4(+) T cells directly ex vivo and primarily in the CD4(+)CD25(-) fraction, which was regulated by prolonged TCR stimulation and the presence of IL-27...
September 19, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28929188/differential-modulation-of-il-12-family-cytokines-in-autoimmune-islet-graft-failure-in-mice
#12
Feng-Cheng Chou, Heng-Yi Chen, Hsin-Hui Chen, Gu-Jiun Lin, Shih-Hua Lin, Huey-Kang Sytwu
AIMS/HYPOTHESIS: The relative contribution of T helper (Th)1 and Th17 cells in graft rejection is inconclusive, on the basis of evidence provided by different T cell-related cytokine-deficient animal models and graft types. METHODS: We used novel antigen-presenting-cell-specific Il-12p35 (also known as Il12a)-knockout (KO), IL-23p19-knockdown (KD) and IL-27p28-KD strategies to investigate T cell differentiation in islet graft rejection. RESULTS: In vitro dendritic cell-T cell coculture experiments revealed that dendritic cells from Il-12p35-KO and IL-23p19-KD mice showed reduced ability to stimulate IFN-γ and IL-17 production in T cells, respectively...
September 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28928459/neutrophil-polarization-by-il-27-as-a-therapeutic-target-for-intracerebral-hemorrhage
#13
Xiurong Zhao, Shun-Ming Ting, Chin-Hsuan Liu, Guanghua Sun, Marian Kruzel, Meaghan Roy-O'Reilly, Jaroslaw Aronowski
Shortly after intracerebral hemorrhage, neutrophils infiltrate the intracerebral hemorrhage-injured brain. Once within the brain, neutrophils degranulate, releasing destructive molecules that may exacerbate brain damage. However, neutrophils also release beneficial molecules, including iron-scavenging lactoferrin that may limit hematoma/iron-mediated brain injury after intracerebral hemorrhage. Here, we show that the immunoregulatory cytokine interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28874534/treg-specific-il-27r%C3%AE-deletion-uncovers-a-key-role-for-il-27-in-treg-function-to-control-autoimmunity
#14
Jeongsu Do, Dongkyun Kim, Sohee Kim, Alice Valentin-Torres, Nina Dvorina, Eunjung Jang, Vivekananthan Nagarajavel, Tara M DeSilva, Xiaoxia Li, Angela H Ting, Dario A A Vignali, Stephen A Stohlman, William M Baldwin, Booki Min
Dysregulated Foxp3(+) Treg functions result in uncontrolled immune activation and autoimmunity. Therefore, identifying cellular factors modulating Treg functions is an area of great importance. Here, using Treg-specific Il27ra(-/-) mice, we report that IL-27 signaling in Foxp3(+) Tregs is essential for Tregs to control autoimmune inflammation in the central nervous system (CNS). Following experimental autoimmune encephalomyelitis (EAE) induction, Treg-specific Il27ra(-/-) mice develop more severe EAE. Consistent with the severe disease, the numbers of IFNγ- and IL-17-producing CD4 T cells infiltrating the CNS tissues are greater in these mice...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28874444/modulation-of-cd4-and-cd8-t-cell-function-and-cytokine-responses-in-strongyloides-stercoralis-infection-by-il-27-and-il-37
#15
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Chandrakumar Dolla, Paul Kumaran, Thomas B Nutman, Subash Babu
Strongyloides stercoralis (Ss) infection is associated with diminished antigen - specific Th1- and Th17-associated responses and enhanced Th2-associated responses. IL-27 and IL-37 are 2 known anti-inflammatory cytokines that are highly expressed in Ss infection. We, therefore wanted to examine the role of IL-27 and IL-37 in regulating CD4(+) and CD8(+) T cell responses in Ss infection. To this end, we examined the frequency of Th1/Tc1, Th2/Tc2, Th9/Tc9, Th17/Tc17 and Th22/Tc22 cells in 15 Ss- infected individuals and 10 uninfected individuals, stimulated with parasite antigen following IL-27 or IL-37 neutralization...
September 5, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28863926/association-between-maternal-circulating-il-27-levels-and-preeclampsia
#16
Danial Jahantigh, Mahdieh Mousavi, Forough Forghani, Mohammad Reza Javan, Samaneh Movahedinia, Mahnaz Rezaei
In this study, we investigated the relationship between serum level of IL-27 with preeclampsia and its severity. Fifty-six preeclamptic, 21 health pregnant and 20 health nonpregnant women formed the study group. The levels of IL-27 in maternal circulation were determined by ELISA. IL-27 serum levels were found to be elevated in healthy pregnant and preeclamptic groups as compared to non-pregnant women, this increase was significant in preeclamptic cases (p=0.0004). Moreover, a significant difference of IL-27 serum level was observed between groups and the healthy pregnant controls, (p=0...
August 29, 2017: Cytokine
https://www.readbyqxmd.com/read/28836673/evaluation-of-gene-expression-levels-for-cytokines-in-ocular-toxoplasmosis
#17
Marta Marques Maia, Cristina Silva Meira-Strejevitch, Vera Lucia Pereira-Chioccola, Daise Damaris Carnietto de Hippólito, Valéria Oliveira Silva, Cinara Cássia Brandão de Mattos, Fábio Batista Frederico, Rubens Camargo Siqueira, Luiz Carlos de Mattos
This study evaluated levels for mRNA expression of 7 cytokines in ocular toxoplasmosis. Peripheral blood mononuclear cells (PBMC) of ocular toxoplasmosis patients (OT Group, n= 23) and chronic toxoplasmosis individuals (CHR Group, n= 9) were isolated and stimulated in vitro with T. gondii antigen. Negative controls (NC) were constituted of 7 PBMC samples from individuals seronegative for toxoplasmosis. mRNA expression for cytokines was determined by qPCR. Results showed a significant increase of mRNA levels from antigen stimulated PBMCs derived from OT Group for expressing IL-6 (at p<0...
August 24, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28835457/neuroendocrine-modulation-of-il-27-in-macrophages
#18
Julian Roewe, Maximilian Higer, Dennis R Riehl, Adrian Gericke, Markus P Radsak, Markus Bosmann
Heterodimeric IL-27 (p28/EBV-induced gene 3) is an important member of the IL-6/IL-12 cytokine family. IL-27 is predominantly synthesized by mononuclear phagocytes and exerts immunoregulatory functional activities on lymphocytic and nonlymphocytic cells during infection, autoimmunity or neoplasms. There is a great body of evidence on the bidirectional interplay between the autonomic nervous system and immune responses during inflammatory disorders, but so far IL-27 has not been defined as a part of these multifaceted neuroendocrine networks...
August 23, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28828696/association-of-il-27-rs153109-and-rs17855750-polymorphisms-with-risk-and-response-to-therapy-in-acute-lymphoblastic-leukemia
#19
Alireza Ghavami, Gholamreza Fathpour, Zahra Amirghofran
Interleukin (IL)-27 is a cytokine with important anti-cancer activity. This study has evaluated the effects of IL-27 rs153109 and rs17855750 single nucleotide polymorphisms (SNPs) on risk of acute lymphoblastic leukemia (ALL) development, as well as their impact on prognosis and patient survival. A total of 200 patients and 210 healthy subjects were genotyped by polymerase chain reaction-restriction fragment length polymorphism. We observed a higher frequency of rs153109 AG and rs17855750 TG genotypes and allele G in patients compared to controls (p < 0...
August 21, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28828208/protein-microarray-analysis-identifies-key-cytokines-associated-with-malignant-middle-cerebral-artery-infarction
#20
Zhonghe Zhou, Jinghua Zhang, Xiaoqiu Li, Cheng Xia, Yaling Han, Huisheng Chen
INTRODUCTION: We aimed to explore potential cytokines involved in the malignant middle cerebral artery infarction (MMI) and elucidate their underlying regulatory mechanisms. METHODS: We first developed a cytokine profile by Quantibody(®) Human Cytokine Antibody Array7000 using serum samples from eight patients with MMI and eight patients with non-acute cerebral infarction (NACI). The differentially expressed cytokines were then identified in patients with MMI using two-tailed Student's t-test and Fisher's Exact Test compared with patients with NACI...
August 2017: Brain and Behavior
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