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Vestibular testing

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https://www.readbyqxmd.com/read/29456166/head-stabilisation-in-fast-running-lizards
#1
Jana Goyens, Peter Aerts
The cyclic patterns of terrestrial animal locomotion are frequently perturbed in natural environments. The terrain can be complex or inclined, the substrate can move unexpectedly and animals can misjudge situations. Loosing stability due to perturbations increases the probability of capture by predators and decreases the chance of successful prey capture and winning intraspecific battles. When controlled corrective actions are necessary to negotiate perturbations, animals rely on their exteroceptive and proprioceptive senses to monitor the environment and their own body movements...
November 29, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/29450484/neurological-manifestations-among-us-government-personnel-reporting-directional-audible-and-sensory-phenomena-in-havana-cuba
#2
Randel L Swanson, Stephen Hampton, Judith Green-McKenzie, Ramon Diaz-Arrastia, M Sean Grady, Ragini Verma, Rosette Biester, Diana Duda, Ronald L Wolf, Douglas H Smith
Importance: From late 2016 through August 2017, US government personnel serving on diplomatic assignment in Havana, Cuba, reported neurological symptoms associated with exposure to auditory and sensory phenomena. Objective: To describe the neurological manifestations that followed exposure to an unknown energy source associated with auditory and sensory phenomena. Design, Setting, and Participants: Preliminary results from a retrospective case series of US government personnel in Havana, Cuba...
February 15, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29449721/bi-allelic-inactivating-variants-in-the-coch-gene-cause-autosomal-recessive-prelingual-hearing-impairment
#3
Sebastien P F JanssensdeVarebeke, Guy Van Camp, Nils Peeters, Ellen Elinck, Josine Widdershoven, Tony Cox, Kristof Deben, Katrien Ketelslagers, Tom Crins, Wim Wuyts
Pathogenic variant in COCH are a known cause of DFNA9 autosomal dominant progressive hearing loss and vestibular dysfunction with adult onset. Hitherto, only dominant nonsynonymous variants and in-frame deletions with a presumed dominant negative or gain-of-function effect have been described. Here, we describe two brothers with congenital prelingual deafness and a homozygous nonsense c.292C>T(p.Arg98*) COCH variant, suggesting a loss-of-function effect. Vestibular dysfunction starting in the first decade was observed in the older patient...
February 15, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29447907/wilhelm-his-lasting-insights-into-hindbrain-and-cranial-ganglia-development-and-evolution
#4
REVIEW
Joel C Glover, Karen L Elliott, Albert Erives, Victor V Chizhikov, Bernd Fritzsch
Wilhelm His (1831-1904) provided lasting insights into the development of the central and peripheral nervous system using innovative technologies such as the microtome, which he invented. 150 years after his resurrection of the classical germ layer theory of Wolff, von Baer and Remak, his description of the developmental origin of cranial and spinal ganglia from a distinct cell population, now known as the neural crest, has stood the test of time and more recently sparked tremendous advances regarding the molecular development of these important cells...
February 12, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29447806/pediatric-meniere-s-disease
#5
Chi Wang, Chien-Hao Wu, Po-Wen Cheng, Yi-Ho Young
OBJECTIVE: This study adopted an inner ear test battery comprising audiometry, and ocular vestibular evoked myogenic potential (oVEMP), cervical VEMP (cVEMP), and caloric tests to investigate the sequence of inner ear deficits in pediatric Meniere's disease (MD). METHODS: From 2005 to 2016, a total of 24 MD children aged <15 years old underwent otoscopy, CT scan, blood test, and an inner ear test battery. Nine subjects were males and 15 were females, with mean age of 12 years...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29440379/targeting-the-cmet-pathway-augments-radiation-response-without-adverse-effect-on-hearing-in-nf2-schwannoma-models
#6
Yingchao Zhao, Pinan Liu, Na Zhang, Jie Chen, Lukas D Landegger, Limeng Wu, Fu Zhao, Yanxia Zhao, Yanling Zhang, Jing Zhang, Takeshi Fujita, Anat Stemmer-Rachamimov, Gino B Ferraro, Hao Liu, Alona Muzikansky, Scott R Plotkin, Konstantina M Stankovic, Rakesh K Jain, Lei Xu
Neurofibromatosis type II (NF2) is a disease that needs new solutions. Vestibular schwannoma (VS) growth causes progressive hearing loss, and the standard treatment, including surgery and radiotherapy, can further damage the nerve. There is an urgent need to identify an adjunct therapy that, by enhancing the efficacy of radiation, can help lower the radiation dose and preserve hearing. The mechanisms underlying deafness in NF2 are still unclear. One of the major limitations in studying tumor-induced hearing loss is the lack of mouse models that allow hearing testing...
February 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29439863/towards-the-enhancement-of-body-standing-balance-recovery-by-means-of-a-wireless-audio-biofeedback-system
#7
Giovanni Costantini, Daniele Casali, Fabio Paolizzo, Marco Alessandrini, Alessandro Micarelli, Andrea Viziano, Giovanni Saggio
Human maintain their body balance by sensorimotor controls mainly based on information gathered from vision, proprioception and vestibular systems. When there is a lack of information, caused by pathologies, diseases or aging, the subject may fall. In this context, we developed a system to augment information gathering, providing the subject with warning audio-feedback signals related to his/her equilibrium. The system comprises an inertial measurement unit (IMU), a data processing unit, a headphone audio device and a software application...
February 10, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29438424/vestibular-schwannomas-accuracy-of-tumor-volume-estimated-by-ice-cream-cone-formula-using-thin-sliced-mr-images
#8
Hsing-Hao Ho, Ya-Hui Li, Jih-Chin Lee, Chih-Wei Wang, Yi-Lin Yu, Dueng-Yuan Hueng, Hsin-I Ma, Hsian-He Hsu, Chun-Jung Juan
PURPOSE: We estimated the volume of vestibular schwannomas by an ice cream cone formula using thin-sliced magnetic resonance images (MRI) and compared the estimation accuracy among different estimating formulas and between different models. METHODS: The study was approved by a local institutional review board. A total of 100 patients with vestibular schwannomas examined by MRI between January 2011 and November 2015 were enrolled retrospectively. Informed consent was waived...
2018: PloS One
https://www.readbyqxmd.com/read/29436794/the-follow-up-role-of-the-vestibular-evoked-myogenic-potential-test-in-meniere-s-disease
#9
Nasrin Yazdani, Farzaneh Nejadian, Nima Rezazadeh, Reza Hoseinabadi, Ebrahim Karimi, Reza Gharibi, Sasan Dabiri
Despite some proposed roles for the diagnostic impact of the cervical vestibular evoked myogenic potential test in the patients with Meniere's disease, the role of this test as an objective instrument in following up the patients with Meniere's disease who underwent. Intratympanic steroid injection is not cleared. In a prospective study, thirty-one adult patients with definite one-sided Meniere's disease with vertigo as main complaint refractory to medical treatments for three months, were selected. Patients underwent three times of intratympanic dexamethasone injection with one-week intervals...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29432406/examination-of-utricular-response-using-ovemp-and-unilateral-centrifugation-rotation-testing
#10
Christopher K Zalewski, R Steven Ackley, Devin L McCaslin, M Diane Clark, Wendy D Hanks, Carmen C Brewer
OBJECTIVES: Significant advancements have been made toward the clinical assessment of utricular function through ocular vestibular-evoked myogenic potentials (oVEMP) and unilateral centrifugation (UCF) testing. To date, no study has examined intrasubject relationships between these measures. The study hypothesis was that intrasubject responses from oVEMP and UCF testing would be correlated inasmuch as both tests have been reported to assess utricular function. DESIGN: UCF rotations and oVEMP testing were performed on healthy volunteers, aged 18 to 62 years...
February 10, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29416772/identification-of-a-novel-myo7a-mutation-in-usher-syndrome-type-1
#11
Ling Cheng, Hongsong Yu, Yan Jiang, Juan He, Sisi Pu, Xin Li, Li Zhang
Usher syndrome (USH) is an autosomal recessive disease characterized by deafness and retinitis pigmentosa. In view of the high phenotypic and genetic heterogeneity in USH, performing genetic screening with traditional methods is impractical. In the present study, we carried out targeted next-generation sequencing (NGS) to uncover the underlying gene in an USH family (2 USH patients and 15 unaffected relatives). One hundred and thirty-five genes associated with inherited retinal degeneration were selected for deep exome sequencing...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29402608/instrumental-head-impulse-test-changes-after-intratympanic-gentamicin-for-unilateral-definite-m%C3%A3-ni%C3%A3-re-s-disease-a-systematic-review-and-meta-analysis
#12
Pedro Santos Marques, Claudia Camila Dias, Nicolas Perez-Fernandez, Jorge Spratley
OBJECTIVE: To estimate how much could intratympanic gentamicin (ITG) interfere with the vestibular-ocular reflex (VOR) parameters on instrumental head impulse test (HIT), either with scleral search coil or video head impulse test and, eventually, foresee the control of vertigo crisis in unilateral intractable Ménière's disease (MD). METHODS: A literature search was conducted in PubMed, Scopus, Web of Science and Cochrane search engines. The search terms used were "vestibular ocular reflex", "head impulse test", "gentamicin," and "Meniere's disease"...
February 2, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29402186/equilibrium-disorders-in-workers-exposed-to-mixed-solvents
#13
Concetto Giorgianni, Mariagiuseppina Tanzariello, Domenico De Pasquale, Renato Brecciaroli, Giovanna Spatari
BACKGROUND: Organic solvents cause diseases of the vestibular system. However, little is known regarding the correlation between vestibular damage and exposure to organic solvents below threshold limit values. The best measure by which to evaluate vestibular disorders is static and dynamic posturography. OBJECTIVE: The aim of this study was to evaluate equilibrium disorders via static and dynamic posturography in workers without clear symptoms and exposed to low doses of mixed solvents...
February 6, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29401065/cervical-vestibular-evoked-myogenic-potential-in-hypoglossal-nerve-schwannoma-a-case-report
#14
Aravind Kumar Rajasekaran, Amey Rajan Savardekar, Nagaraja Rao Shivashankar
BACKGROUND: Schwannoma of the hypoglossal nerve is rare. This case report documents an atypical abnormality of the cervical vestibular evoked myogenic potential (cVEMP) in a patient with schwannoma of the hypoglossal nerve. The observed abnormality was attributed to the proximity of the hypoglossal nerve to the spinal accessory nerve in the medullary cistern and base of the skull. PURPOSE: To report cVEMP abnormality in a patient with hypoglossal nerve schwannoma and provide an anatomical correlation for this abnormality...
February 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29401064/higher-asymmetry-ratio-and-refixation-saccades-in-individuals-with-motion-sickness
#15
Anuj Kumar Neupane, Krithika Gururaj, Sujeet Kumar Sinha
BACKGROUND: Motion sickness is a complex autonomic phenomenon caused by the intersensory conflict among the balancing systems, resulting in a mismatch of signals between static physical conditions of the susceptible individual exposed to dynamic environment. PURPOSE: The present study was done to assess the sacculocollic reflex pathway and six semicircular canals in individuals susceptible to motion sickness. RESEARCH DESIGN: Standard group comparison was used...
February 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29400688/treatment-of-vestibular-disorders-with-weak-asymmetric-base-in-prisms-an-hypothesis-with-a-focus-on-m%C3%A3-ni%C3%A3-re-s-disease
#16
Jelte E Bos, Astrid J A Lubeck, P Eric M Vente
BACKGROUND: Regular treatments of Ménière's disease (MD) vary largely, and no single satisfactory treatment exists. A complementary treatment popular among Dutch and Belgian patients involves eyeglasses with weak asymmetric base-in prisms, with a perceived high success rate. An explanatory mechanism is, however, lacking. OBJECTIVE: To speculate on a working mechanism explaining an effectiveness of weak asymmetric base-in prims in MD, based on available knowledge...
2018: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29400687/vergence-increases-the-gain-of-the-human-angular-vestibulo-ocular-reflex-during-peripheral-hyposensitivity-elicited-by-cold-thermal-irrigation
#17
László T Tamás, Yunxia W Lundberg, Béla Büki
BACKGROUND: When viewing a far target, the gain of the horizontal vestibulo-ocular reflex (VOR) is around 1.0, but when viewing a near target there is an increased response. It has been shown that while this convergence-mediated modulation is unaffected by canal plugging and clinically practical transmastoid galvanic stimulation, it is eliminated by a partial peripheral gentamicin lesion. OBJECTIVE: The aim of this study was to determine if convergence increases the gain during peripheral hyposensitivity elicited by cold thermal irrigation...
2018: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29395695/a-new-diagnostic-approach-to-the-adult-patient-with-acute-dizziness
#18
Jonathan A Edlow, Kiersten L Gurley, David E Newman-Toker
BACKGROUND: Dizziness, a common chief complaint, has an extensive differential diagnosis that includes both benign and serious conditions. Emergency physicians must distinguish the majority of patients with self-limiting conditions from those with serious illnesses that require acute treatment. OBJECTIVE OF THE REVIEW: This article presents a new approach to diagnosis of the acutely dizzy patient that emphasizes different aspects of the history to guide a focused physical examination with the goal of differentiating benign peripheral vestibular conditions from dangerous posterior circulation strokes in the emergency department...
January 31, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29393172/saccular-impairment-in-alzheimer-s-disease-is-associated-with-driving-difficulty
#19
Eric X Wei, Esther S Oh, Aisha Harun, Matthew Ehrenburg, Yuri Agrawal
BACKGROUND/AIMS: Patients with Alzheimer's disease (AD) experience increased rates of vestibular loss. Recent studies suggest that saccular impairment in mild cognitive impairment (MCI) and AD patients is associated with impaired spatial cognitive function. However, the impact of saccular impairment on everyday behaviors that rely on spatial cognitive function is unknown. METHODS: We recruited 60 patients (21 MCI and 39 AD) from an interdisciplinary Memory Clinic...
January 26, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29386274/efficacy-of-balance-and-eye-movement-exercises-for-persons-with-multiple-sclerosis-beems
#20
Jeffrey R Hebert, John R Corboy, Timothy Vollmer, Jeri E Forster, Margaret Schenkman
OBJECTIVE: To determine whether a multifaceted vestibular-related rehabilitation program (Balance and Eye-Movement Exercises for Persons with Multiple Sclerosis; BEEMS) improves balance in persons with MS and whether there are differences in outcomes based on brainstem/cerebellar lesion involvement. METHODS: A 2-arm, examiner-blinded, stratified (involvement vs no involvement of brainstem/cerebellar structures), randomized controlled trial was implemented. Eighty-eight participants were allocated to BEEMS or no treatment control...
January 31, 2018: Neurology
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