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Vestibular testing

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https://www.readbyqxmd.com/read/28538150/lanthanides-report-calcium-sensor-in-the-vestibule-of-ryanodine-receptor
#1
Sándor Sárközi, István Komáromi, István Jóna, János Almássy
Ca(2+) regulates ryanodine receptor's (RyR) activity through an activating and an inhibiting Ca(2+)-binding site located on the cytoplasmic side of the RyR channel. Their altered sensitivity plays an important role in the pathology of malignant hyperthermia and heart failure. We used lanthanide ions (Ln(3+)) as probes to investigate the Ca(2+) sensors of RyR, because they specifically bind to Ca(2+)-binding proteins and they are impermeable to the channel. Eu(3+)'s and Sm(3+)'s action was tested on single RyR1 channels reconstituted into planar lipid bilayers...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28534730/big-stimulus-little-ears-safety-in-administering-vestibular-evoked-myogenic-potentials-in-children
#2
Megan L A Thomas, Denis Fitzpatrick, Ryan McCreery, Kristen L Janky
BACKGROUND: Cervical and ocular vestibular-evoked myogenic potentials (VEMPs) have become common clinical vestibular assessments. However, VEMP testing requires high intensity stimuli, raising concerns regarding safety with children, where sound pressure levels may be higher due to their smaller ear canal volumes. PURPOSE: The purpose of this study was to estimate the range of peak-to-peak equivalent sound pressure levels (peSPLs) in child and adult ears in response to high intensity stimuli (i...
May 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28533763/is-alteration-of-tuning-property-in-cervical-vestibular-evoked-myogenic-potential-specific-for-m%C3%A3-ni%C3%A3-re-s-disease
#3
Toshihisa Murofushi, Masahito Tsubota, Ryota Suizu, Eriko Yoshimura
OBJECTIVE: The aim of this study is to show sensitivity and specificity of cervical vestibular-evoked myogenic potential (cVEMP) tuning property test to Ménière's disease (MD) in comparison with healthy controls (HC) and patients with other vestibular diseases. SUBJECTS: Totally 92 subjects (50 women and 42 men, 20-77 years of age) were enrolled in this study. Subjects were composed of 38 definite unilateral MD patients, 11 unilateral benign paroxysmal positional vertigo patients, 14 vestibular migraine patients, 19 unilateral vestibular neuritis patients, and 10 HC...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28530253/sensitivity-and-specificity-of-vestibular-bedside-examination-in-detecting-viii-cranial-nerve-schwannoma-with-sensorineural-sudden-unilateral-hearing-loss-as-presenting-symptom
#4
L Califano, F Salafia, M G Melillo, S Mazzone
The objectives of this study were to identify signs of vestibular nerve suffering through a bedside vestibular examination protocol in case of sudden sensorineural unilateral hearing loss without spontaneous signs of vestibular impairment and to propose a bed-side vestibular examination based protocol for the focused execution of gadolinium-enhanced magnetic resonance imaging (MRI) only if a vestibular schwannoma is suspected. 96 patients, 52 men, 44 women, mean age 57.73 +/- 12.85 years, suffering from sudden sensorineural unilateral hearing loss, which presented neither vertigo nor spontaneous nystagmus, were enrolled...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28520665/family-history-of-migraine-associated-with-posttraumatic-migraine-symptoms-following-sport-related-concussion
#5
Alicia Sufrinko, Jamie McAllister-Deitrick, R J Elbin, Michael W Collins, Anthony P Kontos
OBJECTIVE: To determine whether family history of migraine increased the likelihood of posttraumatic migraine (PTM) symptom presentation in adolescents following concussion, and examine the influence of family history of migraine and PTM on postinjury outcomes. SETTING: Outpatient concussion clinic. PARTICIPANTS: A total of 153 patients with concussion (103 males and 50 females) aged 15.72 ± 1.48 years (range 12-18 years). DESIGN: Cross-sectional, observational study of patients presenting for initial evaluation 4...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28516967/body-worn-triaxial-accelerometer-coherence-and-reliability-related-to-static-posturography-in-unilateral-vestibular-failure
#6
M Alessandrini, A Micarelli, A Viziano, I Pavone, G Costantini, D Casali, F Paolizzo, G Saggio
Since changes in vestibular function may be one cause of disequilibrium, major advances in measuring postural control and sensory integration in vestibular impairments have been achieved by using posturography. However, in order to overcome problems related to this type of technology, body-worn accelerometers (ACC) have been proposed as a portable, low-cost alternative to posturography for measurements of postural sway in a friendly and ecologic environment. Due to the fact that no study to date has shown the experimental validity of ACC-based measures of body sway with respect to posturography for subjects with vestibular deficits, the aim of the present study was: i) to develop and validate a practical tool that can allow clinicians to measure postural sway derangements in an otoneurological setting by ACC, and ii) to provide reliable, sensitive and accurate automatic analysis of sway that could help in discriminating unilateral vestibular failure (UVF) patients...
June 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28515458/floccular-fossa-size-is-not-a-reliable-proxy-of-ecology-and-behaviour-in-vertebrates
#7
S Ferreira-Cardoso, R Araújo, N E Martins, G G Martins, S Walsh, R M S Martins, N Kardjilov, I Manke, A Hilger, R Castanhinha
The cerebellar floccular and parafloccular lobes are housed in fossae of the periotic region of the skull of different vertebrates. Experimental evidence indicates that the lobes integrate visual and vestibular information and control the vestibulo-ocular reflex, vestibulo-collic reflex, smooth pursuit and gaze holding. Multiple paleoneuroanatomy studies have deduced the behaviour of fossil vertebrates by measuring the floccular fossae (FF). These studies assumed that there are correlations between FF volume and behaviour...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28511610/women-without-vulvodynia-can-have-a-positive-q-tip-test-a-cross-sectional-study
#8
Pedro Vieira-Baptista, Joana Lima-Silva, Jorge Beires, Gilbert Donders
BACKGROUND: Vulvodynia is a frequently missed pathology, often confused with vaginismus. The Q-tip test (QTT) is fundamental for the diagnosis; however, there is lack of data about its performance in asymptomatic women. OBJECTIVE: This study intended to evaluate the QTT for painful vestibular spots in asymptomatic women. METHODS: Q-tips were gently pressed at different areas of the vulvar vestibule to obtain a 0-10 score representing the pain felt...
May 17, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28499299/-current-diagnostic-procedures-for-diagnosing-vertigo-and-dizziness
#9
Leif Erik Walther
Modern diagnostic methods such as video head impulse test and cervical and ocular vestibular evoked myogenic potentials allow to measure canal and otolith function quantitatively and objectively. These methods contribute to a complex assessment of the functional integrity of all 5 sensory elements of the vestibular organ for the first time. Moreover, in combination with additional vestibular tests frequency specific and time depended changes of impairments of vestibular sensors and their pathways can be assessed...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28498271/epidemiology-of-dizzy-patient-population-in-a-neurotology-clinic-and-predictors-of-peripheral-etiology
#10
Thomas Muelleman, Matthew Shew, Rahul Subbarayan, Axel Shum, Kevin Sykes, Hinrich Staecker, James Lin
OBJECTIVE: To compare the proportion of peripheral versus nonperipheral dizziness etiologies among all patients, inclusive of those presenting primarily or as referrals, to rank diagnoses in order of frequency, to determine whether or not age and sex predict diagnosis, and to determine which subgroups tended to undergo formal vestibular testing. STUDY DESIGN: Retrospective cohort. SETTING: Academic neurotology clinic. PATIENTS: Age greater than 18 neurotology clinic patients with the chief complaint of dizziness...
May 11, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28496432/vestibular-loss-in-older-adults-is-associated-with-impaired-spatial-navigation-data-from-the-triangle-completion-task
#11
Yanjun Xie, Robin T Bigelow, Scott F Frankenthaler, Stephanie A Studenski, Scott D Moffat, Yuri Agrawal
BACKGROUND: Vestibular inputs have been shown to play a critical role in spatial navigation. In this study, we sought to evaluate whether vestibular loss due to aging contributes to impaired spatial navigation as measured by the triangle completion task (TCT). MATERIALS AND METHODS: We recruited three types of participants: young controls <55 years of age, older controls ≥55 years of age, and older patients from a Neurotology Clinic with evidence of vestibular physiologic impairment but who did not have any known vestibular disorder...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28493872/geographic-distribution-of-vestibular-schwannomas-in-west-scotland-between-2000-2015
#12
Lisa Caulley, Michael Sawada, Kelsey Hinther, Ya-Tung Iris Ko, John A Crowther, Georgios Kontorinis
BACKGROUND: Although the natural history of vestibular schwannomas (VS) has been previously studied, few studies have investigated associated epidemiological factors, primarily because of the lack of large available cohorts. OBJECTIVE: The objective of this study was to perform a multi-scale geographical analysis of the period prevalence of VS in West Scotland from 2000 to 2015. METHODS: Adults diagnosed with sporadic VS were identified through the National Health Services of West Scotland database and geocoded to the unit postcode...
2017: PloS One
https://www.readbyqxmd.com/read/28491901/predictors-of-clinical-recovery-from-vestibular-neuritis-a-prospective-study
#13
Sian Cousins, Diego Kaski, Nicholas Cutfield, Qadeer Arshad, Hena Ahmad, Michael A Gresty, Barry M Seemungal, John Golding, Adolfo M Bronstein
We sought to identify predictors of symptomatic recovery in vestibular neuritis. Forty VN patients were prospectively studied in the acute phase (median = 2 days) and 32 in the recovery phase (median = 10 weeks) with vestibulo-ocular reflex, vestibular-perceptual, and visual dependence tests and psychological questionnaires. Clinical outcome was Dizziness Handicap Inventory score at recovery phase. Acute visual dependency and autonomic arousal predicted outcome. Worse recovery was associated with a combination of increased visual dependence, autonomic arousal, anxiety/depression, and fear of bodily sensations, but not with vestibular variables...
May 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28489659/relationship-between-the-quantity-of-nerve-exposure-during-bilateral-sagittal-split-osteotomy-surgery-and-sensitive-recovery
#14
Paolo Gennaro, Maria Elisa Giovannoni, Niccolò Pini, Ikenna Valentine Aboh, Guido Gabriele, Giorgio Iannetti, Flavia Cascino
AIM AND OBJECTIVES: The purpose of this study was to evaluate how different exposures of the V3 nerves during orthognathic surgery impact neurosensory disturbances. METHODS: The study included 127 patients who underwent either bilateral sagittal split osteotomy (BSSO) or BSSO with maxillary le Fort 1. They were divided into 6 groups, identified by the quantity of V3 nerve exposure. All patients were examined in a pre-op period and again after 1, 3, 6 months post-op...
May 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28486738/-isolated-high-frequency-hvor-lesion-in-patients-with-chronic-dizziness
#15
Roland Hülse, Manfred Hülse, Karl Hörmann, Matthias Hölzl, Richard Birk, Angela Wenzel
In the presented study video-head impulse test (vHIT) was performed in 72 patients with complaints of dizziness for more than 3 months who did not show any pathology in rotatory chair testing or caloric test, in order to analyzed high frequency vestibular-ocular-reflex (VOR). Retrospective data analyzed of rotatory chair testing, caloric tests and vHIT results were accomplished in 72 patients. Gain, gain variance and the occurrence of catch-up saccades were measured. 10 patients (n=10; 13.8%) showed pathologic vHOR results with reduced gain...
May 9, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28486231/decrease-of-horizontal-canal-vestibulo-oculomotor-reflex-gain-in-the-elderly-with-dysequilibrium-without-lifetime-vertigo
#16
Roberto Teggi, Matteo Trimarchi, Omar Gatti, Francesco Fornasari, Mario Bussi
BACKGROUND/AIMS: Unsteadiness in the elderly is a frequent complaint and a strong predictor of falls and psychological distress. Although there is a general consensus that it is a multifactorial condition, recent studies have focused on the role of aging of the vestibular system as a possible cofactor. The aim of our work was to assess horizontal canal function in the elderly. METHODS: We evaluated the gain of horizontal vestibulo-ocular reflex (VOR) with a video head impulse test on a sample of 58 subjects aged >70 years without lifetime episodes of vertigo and correlated the value with different clinical conditions (hypertension, diabetes, prior cardiovascular and vascular disorders of the central nervous system, and falls)...
May 10, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28485669/postural-stability-in-a-population-of-dancers-healthy-non-dancers-and-vestibular-neuritis-patients
#17
Eduardo Martin-Sanz, Isabel Ortega Crespo, Jonathan Esteban-Sanchez, Ricardo Sanz
INTRODUCTION: Several studies have indicated better balance control in dancers than in control participants, but some controversy remains. The aim of our study is to evaluate the postural stability in a cohort of dancers, non-dancers, compensated, and non-compensated unilateral vestibular neuritis (VN). METHODS: This is a prospective study of control subjects, dancers, and VN patients between June 2009 and December 2015. Dancers from the Dance Conservatory of Madrid and VN patients were referred to our department for analysis...
May 9, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28485291/por%C3%A3-wnanie-cz%C3%A4-sto%C3%A5-ci-wyst%C3%A4-powania-objaw%C3%A3-w-wsp%C3%A3-%C3%A5-istniej%C3%A4-cych-w-grupie-pacjent%C3%A3-w-z-zawrotami-g%C3%A5-owy
#18
Jakub Šichnárek, Jana Vyskotová, Kateřina Macháčková, Eva Mrázková
BACKGROUND: Dizziness is the second most frequent symptom that make patients seek specialized examination. The effective solution of dizzy conditions requires treatment in cooperation with different branches of medicine. OBJECTIVE: To analyze data from the database of patients with vertigo examined in the Hearing and Balance Disorder Centre in Ostrava, to find out whether, and in what factors, the sets of patients with diagnosed central and peripheral vestibular syndrom differ from each other...
February 28, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28484820/-vertigo-and-dizziness-in-the-emergency-room
#19
REVIEW
A Zwergal, K Möhwald, M Dieterich
Vertigo and dizziness are among the most common chief complaints in the emergency department. Etiologies can be categorized into three subgroups: neurootological (vestibular), medical (especially cardiovascular, metabolic), and psychiatric disorders. The diagnostic approach in the emergency department is based on a systematic analysis of case history (type, time course of symptoms, modulating factors, associated symptoms), clinical examination of the vestibular, ocular motor, and cerebellar systems (head impulse test, nystagmus, skew deviation, positioning maneuver, test of gait and stance), as well as a basal monitoring (vital signs, 12-lead ECG, blood tests)...
May 8, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28484380/perceived-intensity-and-discrimination-ability-for-lingual-electrotactile-stimulation-depends-on-location-and-orientation-of-electrodes
#20
Joel Moritz, Philip Turk, John D Williams, Leslie M Stone-Roy
Malfunctioning sensory systems can severely impact quality of life and repair is not always possible. One solution, called sensory substitution, is to use another sensory system to bring lost information to the brain. This approach often involves the use of bioengineered devices that electrically stimulate somatosensory fibers. Interestingly, the tongue is an ideal location for electrotactile stimulation due to its dense innervation, moisture, and protected environment. Success with transmitting visual and vestibular information through the tongue indicates promise for future applications...
2017: Frontiers in Human Neuroscience
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