Read by QxMD icon Read


Stefano Cascinu
The results of the SCALOP trial were reviewed and interpreted at the light of previous trials and of the more recent LAP-07 trial. In this latter trial the role of radiotherapy after an induction chmeotherapy has been questioned. Based on these findings data from the SCALOP trial loose most of their value. In fact, while it showed that capecitabine may be combined with radiotherapy more safely than gemcitabine and it could be a standard regimen as a consolidation regimen after an induction chemotherapy, the LAP-07 trial showed that radiotherapy in combination with chemotherapy does not add any valuable effect to chemotherapy alone...
September 2013: Chinese Clinical Oncology
Ignacio Garrido-Laguna, Manuel Hidalgo
Pancreatic cancer is expected to be the second deadliest malignancy in the USA by 2020. The survival rates for patients with other gastrointestinal malignancies have increased consistently during the past 30 years; unfortunately, however, the outcomes of patients with pancreatic cancer have not changed significantly. Although surgery remains the only curative treatment for pancreatic cancer, therapeutic strategies based on initial resection have not substantially improved the survival of patients with resectable disease over the past 25 years; presently, more than 80% of patients suffer disease relapse after resection...
June 2015: Nature Reviews. Clinical Oncology
Tamara M H Gall, Adam E Frampton, Jonathan Krell, Jimmy Jacob, Justin Stebbing, Long R Jiao
Evaluation of: Bidard FC, Huguet F, Louvet C et al. Circulating tumor cells in locally advanced pancreatic adenocarcinoma: the ancillary CirCe 07 study to the LAP 07 trial. Ann. Oncol. 24(8), 2057-2061 (2013). Circulating tumor cells (CTCs) may be shed from the primary tumor and lead to metastatic disease. This evaluated article reports on CTCs in locally advanced pancreatic cancer (LAPC). By assessing CTCs from peripheral blood prior to any treatment and after 2 months of chemotherapy, 11% of patients had detectable CTCs...
November 2013: Expert Review of Molecular Diagnostics
F C Bidard, F Huguet, C Louvet, L Mineur, O Bouché, B Chibaudel, P Artru, F Desseigne, J B Bachet, C Mathiot, J Y Pierga, P Hammel
BACKGROUND: Pancreatic carcinoma is one of the leading causes of cancer-related mortality. At the time of diagnosis, 30% of patients present with a locally advanced pancreatic carcinoma (LAPC). As circulating tumor cells (CTCs) count may be a surrogate of the cancer metastatic abilities, CTC detection rates and prognostic value were studied in a prospective cohort of LAPC patients. PATIENTS AND METHODS: An LAP07 international multicenter randomized study assesses in patients whose LAPC is controlled after 4 months of chemotherapy whether chemoradiotherapy could increase survival versus continuation of chemotherapy...
August 2013: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Jia Li, John Ng, John Allendorf, Muhammad W Saif
Pancreatic cancer, as the 4th leading cause of cancer death in the U.S., remains a challenging disease for all oncologists. Less than 20% of all cases could be potentially cured by surgical resection, while the majority of cases are deemed either unresectable or metastatic upon diagnosis. In this year's American Society of Clinical Oncology (ASCO) Annual Meeting, several studies were presented with novel approaches towards treating locally advanced pancreatic cancer. The LAP-07 study, a large phase III study with two separate randomizations, updated their accrual status, but with no interim data yet reported (Abstract #e14619)...
July 2011: JOP: Journal of the Pancreas
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"