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Lung revalidation

Sascha Macherey, Max Schlaak, Fabian Doerr, Sabine Grönke, Matthias Heldwein, Alexander Quaas, Thomas Zander, Khosro Hekmat
Results of previous studies question the benefits of pulmonary surgery in patients with pulmonary metastases from malignant melanoma. A systematic literature search and analysis of articles published since 1 January 2000 was carried out to investigate the advantages of metastasectomy and alternative forms of therapy. Patients reached a median survival time of 17-40 months and 5-year survival rates between 18% and 39.4% after metastasectomy. Intrathoracic recurrence occurred in 30 % of patients but could be successfully treated with re-operations in some cases...
January 2015: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Lisa N MacFadden, Philemon C Chan, Kevin H-H Ho, James H Stuhmiller
BACKGROUND: This article presents a model-based method for predicting primary blast injury. On the basis of the normalized work injury mechanism from previous work, this method presents a new model that accounts for the effects of blast orientation and species difference. METHODS: The analysis used test data from a series of extensive experimental studies sponsored by the US Army Medical Research and Materiel Command. In these studies, more than 1200 sheep were exposed to air blast in free-field and confined enclosures, and lung injuries were quantified as the percentage of surface area contused...
November 2012: Journal of Trauma and Acute Care Surgery
Z J Cheng, G Warwick, D H Yates, P S Thomas
Exhaled breath contains hundreds of volatile organic compounds (VOCs) that may be used as non-invasive markers of lung disease. Electronic noses (e-noses) can analyse VOCs by composite nanosensor arrays with learning algorithms. This study investigated the use of an e-nose (Cyranose C320) to distinguish the breath of smokers from that of non-smokers. Smoking and non-smoking subjects exhaled from total lung capacity into a 2 L Tedlar bag and these samples were introduced offline to the e-nose in a random order...
September 2009: Journal of Breath Research
Dian-ke Yu, Yong-li Guo, Wen Tan, Dong-xin Lin
OBJECTIVE: The Bcl-2 associated X protein (Bax), belonging to the Bcl-2 family, plays a pivotal role in mitochondria-dependent apoptosis. The aims of this study are to revalidate the functional significance of Bax G(-248)A polymorphism, and investigate its association with lung cancer risk in Chinese population. METHODS: The biological function of Bax G(-248)A was tested by luciferase assays, and its effects on lung cancer risk was determined by case-control analysis of 989 patients with lung cancer and 990 controls...
May 2010: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Patrick Calders, Benedicte Deforche, Sabine Verschelde, Jacques Bouckaert, Frederic Chevalier, Eddy Bassle, Ann Tanghe, Patrick De Bode, Hilde Franckx
UNLABELLED: The purpose of this study was to identify predictors of the distance achieved during a 6-minute walk test and a 12-minute walk/run test (Cooper test) in obese children and adolescents and to evaluate the influence of a residential treatment on the association of these predictors with the distance. A search of the Revalidation Centre Zeepreventorium (De Haan, Belgium) medical records database of all children and adolescents (age 10 to 18 yrs) treated for obesity between September 2003 and February 2006, revealed 65 charts with all relevant data (anthropometrical, maximal graded exercise, lung function, 6-minute walk test and 12-minute walk/run test) at admission as well as after 3 months treatment...
May 2008: European Journal of Pediatrics
Thomas P Shakespeare, Michael F Back, Jiade J Lu, Khai Mun Lee, Rahul K Mukherjee
PURPOSE: The external audit of oncologist clinical practice is increasingly important because of the incorporation of audits into national maintenance of certification (MOC) programs. However, there are few reports of external audits of oncology practice or decision making. Our institution (The Cancer Institute, Singapore) was asked to externally audit an oncology department in a developing Asian nation, providing a unique opportunity to explore the feasibility of such a process. METHODS AND MATERIALS: We audited 100 randomly selected patients simulated for radiotherapy in 2003, using a previously reported audit instrument assessing clinical documentation/quality assurance and medical decision making...
March 1, 2006: International Journal of Radiation Oncology, Biology, Physics
W F Whimster
A morphometric technique of point counting was developed for macroscopic use in emphysematous lungs and microscopic use in bronchi to obtain actual areas and volumes, as opposed to ratios or percentages, of emphysema and submucosal glands. The results in emphysematous lungs showed that the volume of emphysema seen in one slice of one lung cannot be used to predict the volume in other slices, nor the volume of emphysema in one lung to predict the volume of emphysema in the other. The results in the airways showed that, if the volume of bronchial glands in each generation along an airway is expressed per unit of luminal surface area, a distinctive profile of gland distribution along the airway is obtained, as well as the mean volume per gland...
September 1985: Analytical and Quantitative Cytology and Histology
R H Warren, S H Alderson
We investigated the accuracy of a computer-assisted, respiratory inductive plethysmograph (Respicomp) on 50 awake human newborns who were lying supine. Breaths were selected with different rib cage (RC) to pneumotach (PNT) and abdomen (AB) to pneumotach (PNT) values. The equation RC/PNT + AB/PNT = 1 was solved using the least squares method (LSQ) of calculation of calibration factors. Validation of the calibration factors was performed with a range of consecutive breaths between 6 and 22. Of the 1,128 validation or revalidation breaths, 628 (56%) were within 10% of the simultaneously measured PNT volume, 1,024 (91%) were within 20%, and 1,128 (100%) were within 30%...
April 1985: American Review of Respiratory Disease
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