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JOURNAL ARTICLE
Cameron B Haas, Kristina M Jordahl, Robin M Nance, Bridget M Whitney, Lu Wang, Joseph A C Delaney, Stephanie Ruderman, Tongqiu Jia, Wm Christopher Mathews, Michael S Saag, Sulggi A Lee, Sonia Napravnik, Jeffrey M Jacobson, Geetanjali Chander, Elizabeth M McCall, Richard D Moore, Kenneth H Mayer, Shubhabrata Mukherjee, Won Jun Lee, Paul K Crane, Heidi Crane, Inga Peter, Sara Lindström
BACKGROUND: The prevalence of substance use in people with HIV (PWH) in the United States is higher than in the general population and is an important driver of HIV-related outcomes. We sought to assess if previously identified genetic associations that contribute to substance use are also observed in a population of PWH. METHODS: We performed genome-wide association studies (GWAS) of alcohol, smoking, and cannabis use phenotypes in a multi-ancestry population of 7,542 PWH from the Center for AIDS Research Network of Integrated Clinical Systems (CNICS)...
2023: PloS One
#22
Yi Wang, Hao-Wei Chang, Evan M Lee, Cyrus Zhou, Kali M Pruss, Suzanne Henrissat, Robert Y Chen, Clara Kao, Matthew C Hibberd, Hannah M Lynn, Daniel M Webber, Marie Crane, Jiye Cheng, Dmitry A Rodionov, Aleksandr A Arzamasov, Juan J Castillo, Garret Couture, Ye Chen, Nikita P Balcazo, Carlito B Lebrilla, Nicolas Terrapon, Bernard Henrissat, Olga Ilkayeva, Michael J Muehlbauer, Christopher B Newgard, Ishita Mostafa, Subhasish Das, Mustafa Mahfuz, Andrei L Osterman, Michael J Barratt, Tahmeed Ahmed, Jeffrey I Gordon
Preclinical and clinical studies are providing evidence that the healthy growth of infants and children reflects, in part, healthy development of their gut microbiomes 1-5 . This process of microbial community assembly and functional maturation is perturbed in children with acute malnutrition. Gnotobiotic animals, colonized with microbial communities from children with severe and moderate acute malnutrition, have been used to develop microbiome-directed complementary food (MDCF) formulations for repairing the microbiomes of these children during the weaning period 5 ...
August 17, 2023: bioRxiv
#23
JOURNAL ARTICLE
Can Wu, Victor Murray, Syed S Siddiq, Neelam Tyagi, Marsha Reyngold, Christopher Crane, Ricardo Otazo
Objective: To develop real-time 4D MRI using MR signature matching (MRSIGMA) for volumetric motion imaging in patients with pancreatic cancer on a 1.5T MR-Linac system.

 Approach: Two consecutive MRI scans with 3D golden-angle radial stack-of-stars acquisitions were performed on ten patients with inoperable pancreatic cancer. The complete first scan (905 angles) was used to compute a 4D motion dictionary including ten pairs of 3D motion images and signatures. The second scan was used for real-time imaging, where each angle (275 ms) was processed separately to match it to one of the dictionary entries...
August 24, 2023: Physics in Medicine and Biology
#24
JOURNAL ARTICLE
James R Hawkins, Marram P Olson, Ahmed Harouni, Ming Melvin Qin, Christopher P Hess, Sharmila Majumdar, Jason C Crane
The medical imaging community has embraced Machine Learning (ML) as evidenced by the rapid increase in the number of ML models being developed, but validating and deploying these models in the clinic remains a challenge. The engineering involved in integrating and assessing the efficacy of ML models within the clinical workflow is complex. This paper presents a general-purpose, end-to-end, clinically integrated ML model deployment and validation system implemented at UCSF. Engineering and usability challenges and results from 3 use cases are presented...
August 2023: PLOS Digit Health
#25
JOURNAL ARTICLE
Leila T Tchelebi, Kathryn A Winter, Ross A Abrams, Howard P Safran, William F Regine, Susan McNulty, Abraham Wu, Kevin L Du, Samantha A Seaward, Shelly X Bian, Raid Aljumaily, Anand Shivnani, Jeanna L Knoble, Todd S Crocenzi, Thomas A DiPetrillo, Kevin S Roof, Christopher H Crane, Karyn A Goodman
PURPOSE: NRG/Radiation Therapy Oncology Group 0848 is a 2-step randomized trial to evaluate the benefit of the addition of concurrent fluoropyrimidine and radiation therapy (RT) after adjuvant chemotherapy (second step) for patients with resected pancreatic head adenocarcinoma. Real-time quality assurance (QA) was performed on each patient who underwent RT. This analysis aims to evaluate adherence to protocol-specified contouring and treatment planning and to report the types and frequencies of deviations requiring revisions...
January 1, 2024: International Journal of Radiation Oncology, Biology, Physics
#26
JOURNAL ARTICLE
Brian De, Rituraj Upadhyay, Kaiping Liao, Tiffany Kumala, Christopher Shi, Grace Dodoo, Joseph Abi Jaoude, Kelsey L Corrigan, Gohar S Manzar, Kathryn E Marqueen, Vincent Bernard, Sunyoung S Lee, Kanwal P S Raghav, Jean-Nicolas Vauthey, Ching-Wei D Tzeng, Hop S Tran Cao, Grace Lee, Jennifer Y Wo, Theodore S Hong, Christopher H Crane, Bruce D Minsky, Grace L Smith, Emma B Holliday, Cullen M Taniguchi, Albert C Koong, Prajnan Das, Milind Javle, Ethan B Ludmir, Eugene J Koay
INTRODUCTION: Tumor-related liver failure (TRLF) is the most common cause of death in patients with intrahepatic cholangiocarcinoma (ICC). Though we previously showed that liver radiotherapy (L-RT) for locally advanced ICC is associated with less frequent TRLF and longer overall survival (OS), the role of L-RT for patients with extrahepatic metastatic disease (M1) remains undefined. We sought to compare outcomes for M1 ICC patients treated with and without L-RT. METHODS: We reviewed ICC patients that found to have M1 disease at initial diagnosis at a single institution between 2010 and 2021 who received L-RT, matching them with an institutional cohort by propensity score and a National Cancer Database (NCDB) cohort by frequency technique...
August 2023: Liver Cancer
#27
JOURNAL ARTICLE
Umedjon Ibragimov, Melvin D Livingston, April M Young, Judith Feinberg, P Todd Korthuis, Wajiha Z Akhtar, Wiley D Jenkins, Heidi M Crane, Ryan P Westergaard, Robin Nance, William C Miller, John Bresett, Dalia Khoury, Christopher B Hurt, Vivian F Go, Kerry Nolte, Hannah L F Cooper
The Rural Opioid Initiative surveyed 2693 people who inject drugs (PWID) in eight rural U.S. areas in 2018-2020 about self-reported HIV testing in the past 6 months. Correlates of interest included receipt of any drug-related services, incarceration history, and structural barriers to care (e.g., lack of insurance, proximity to syringe service programs [SSP]). Overall, 20% of participants reported receiving an HIV test within the past 6 months. Multivariable generalized estimating equations showed that attending substance use disorder (SUD) treatment (OR 2...
July 29, 2023: AIDS and Behavior
#28
Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan-Ping Lee, Jacob Haut, Kara L Hamilton-Nelson, Nicholas R Wheeler, Yi Zhao, John J Farrell, Michelle A Grunin, Yuk Yee Leung, Pavel P Kuksa, Donghe Li, Eder Lucio da Fonseca, Jesse B Mez, Ellen L Palmer, Jagan Pillai, Richard M Sherva, Yeunjoo E Song, Xiaoling Zhang, Taha Iqbal, Omkar Pathak, Otto Valladares, Amanda B Kuzma, Erin Abner, Perrie M Adams, Alyssa Aguirre, Marilyn S Albert, Roger L Albin, Mariet Allen, Lisa Alvarez, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Gayle Ayres, Clinton T Baldwin, Robert C Barber, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Gary W Beecham, Duane Beekly, Bruno A Benitez, David Bennett, John Bertelson, Thomas D Bird, Deborah Blacker, Bradley F Boeve, James D Bowen, Adam Boxer, James Brewer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Laura B Cantwell, Chuanhai Cao, Christopher S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Scott Chasse, Marie-Francoise Chesselet, Nathaniel A Chin, Helena C Chui, Jaeyoon Chung, Suzanne Craft, Paul K Crane, David H Cribbs, Elizabeth A Crocco, Carlos Cruchaga, Michael L Cuccaro, Munro Cullum, Eveleen Darby, Barbara Davis, Philip L De Jager, Charles DeCarli, John DeToledo, Malcolm Dick, Dennis W Dickson, Beth A Dombroski, Rachelle S Doody, Ranjan Duara, NIlüfer Ertekin-Taner, Denis A Evans, Kelley M Faber, Thomas J Fairchild, Kenneth B Fallon, David W Fardo, Martin R Farlow, Victoria Fernandez-Hernandez, Steven Ferris, Tatiana M Foroud, Matthew P Frosch, Brian Fulton-Howard, Douglas R Galasko, Adriana Gamboa, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Alison M Goate, Thomas J Grabowski, Neill R Graff-Radford, Robert C Green, John H Growdon, Hakon Hakonarson, James Hall, Ronald L Hamilton, Oscar Harari, John Hardy, Lindy E Harrell, Elizabeth Head, Victor W Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S Honig, Ryan M Huebinger, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Linda S Hynan, Laura Ibanez, Gail P Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M Ilyas Kamboh, Anna M Karydas, Mindy J Katz, John S Kauwe, Jeffrey A Kaye, C Dirk Keene, Aisha Khaleeq, Ronald Kim, Janice Knebl, Neil W Kowall, Joel H Kramer, Walter A Kukull, Frank M LaFerla, James J Lah, Eric B Larson, Alan Lerner, James B Leverenz, Allan I Levey, Andrew P Lieberman, Richard B Lipton, Mark Logue, Oscar L Lopez, Kathryn L Lunetta, Constantine G Lyketsos, Douglas Mains, Flanagan E Margaret, Daniel C Marson, Eden R R Martin, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Stefan McDonough, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Thomas J Montine, Edwin S Monuki, John C Morris, Shubhabrata Mukherjee, Amanda J Myers, Trung Nguyen, Sid O'Bryant, John M Olichney, Marcia Ory, Raymond Palmer, Joseph E Parisi, Henry L Paulson, Valory Pavlik, David Paydarfar, Victoria Perez, Elaine Peskind, Ronald C Petersen, Aimee Pierce, Marsha Polk, Wayne W Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F Quinn, Ashok Raj, Murray Raskind, Eric M Reiman, Barry Reisberg, Joan S Reisch, John M Ringman, Erik D Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Donald R Royall, Mark A Sager, Mary Sano, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Susan H Slifer, Scott Small, Amanda G Smith, Janet P Smith, Joshua A Sonnen, Salvatore Spina, Peter St George-Hyslop, Robert A Stern, Alan B Stevens, Stephen M Strittmatter, David Sultzer, Russell H Swerdlow, Rudolph E Tanzi, Jeffrey L Tilson, John Q Trojanowski, Juan C Troncoso, Debby W Tsuang, Vivianna M Van Deerlin, Linda J van Eldik, Jeffery M Vance, Badri N Vardarajan, Robert Vassar, Harry V Vinters, Jean-Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Patrice L Whitehead, Ellen M Wijsman, Kirk C Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S Wingo, Thomas Wisniewski, Randall L Woltjer, Martin Woon, Clinton B Wright, Chuang-Kuo Wu, Steven G Younkin, Chang-En Yu, Lei Yu, Xiongwei Zhu, Brian W Kunkle, William S Bush, Li-San Wang, Lindsay A Farrer, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard D Schellenberg, Gyungah R Jun, Christiane Reitz, Adam C Naj
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer's Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within-ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis...
July 8, 2023: medRxiv
#29
JOURNAL ARTICLE
Thai M Hoang, Sang K Chung, Thanh Le, Sehyun Park, Sung-Jin Park, J Gary Eden, Christopher Holland, Hao Wang, Omeed Momeni, Russell Bradley, Scott Crane, John D Prestage, Nan Yu
Modern communication and navigation systems are increasingly relying on atomic clocks. As timing precision requirements increase, demands for lower SWaP (size, weight, and power) clocks rise. However, it has been challenging to break through the general trade-off trend between the clock stability performance and SWaP. Here we demonstrate micro mercury trapped ion clock (M2TIC) prototypes integrated with novel micro-fabricated technologies to simultaneously achieve high performance and low SWaP. The M2TIC prototypes could reach the [Formula: see text]-stability level in 1 day with a SWaP of 1...
June 30, 2023: Scientific Reports
#30
JOURNAL ARTICLE
Adam Trickey, Suzanne M Ingle, Anders Boyd, M John Gill, Sophie Grabar, Inma Jarrin, Niels Obel, Giota Touloumi, Robert Zangerle, Andri Rauch, Christopher T Rentsch, Derek D Satre, Michael J Silverberg, Fabrice Bonnet, Jodie Guest, Greer Burkholder, Heidi Crane, Ramon Teira, Juan Berenguer, Christoph Wyen, Sophie Abgrall, Mojgan Hessamfar, Peter Reiss, Antonella d'Arminio Monforte, Kathleen A McGinnis, Jonathan A C Sterne, Linda Wittkop
Among persons with HIV (PWH), higher alcohol use and having hepatitis C virus (HCV) are separately associated with increased morbidity and mortality. We investigated whether the association between alcohol use and mortality among PWH is modified by HCV. Data were combined from European and North American cohorts of adult PWH who started antiretroviral therapy (ART). Self-reported alcohol use data, collected in diverse ways between cohorts, were converted to grams/day. Eligible PWH started ART during 2001-2017 and were followed from ART initiation for mortality...
June 20, 2023: Journal of Viral Hepatitis
#31
JOURNAL ARTICLE
Jue Jiang, Jun Hong, Kathryn Tringale, Marsha Reyngold, Christopher Crane, Neelam Tyagi, Harini Veeraraghavan
BACKGROUND: Adaptive radiation treatment (ART) for locally advanced pancreatic cancer (LAPC) requires consistently accurate segmentation of the extremely mobile gastrointestinal (GI) organs at risk (OAR) including the stomach, duodenum, large and small bowel. Also, due to lack of sufficiently accurate and fast deformable image registration (DIR), accumulated dose to the GI OARs is currently only approximated, further limiting the ability to more precisely adapt treatments. PURPOSE: Develop a 3-D Progressively refined joint Registration-Segmentation (ProRSeg) deep network to deformably align and segment treatment fraction magnetic resonance images (MRI)s, then evaluate segmentation accuracy, registration consistency, and feasibility for OAR dose accumulation...
June 2, 2023: Medical Physics
#32
JOURNAL ARTICLE
Won Jun Lee, Haoxiang Cheng, Bridget M Whitney, Robin M Nance, Sierra R Britton, Kristina Jordahl, Sara Lindstrom, Stephanie A Ruderman, Mari M Kitahata, Michael S Saag, Amanda L Willig, Greer Burkholder, Joseph J Eron, Jason C Kovacic, Johan L M Björkegren, W Christopher Mathews, Edward Cachay, Matthew J Feinstein, Mathew Budoff, Peter W Hunt, Richard D Moore, Jeanne Keruly, Mary E McCaul, Geetanjali Chander, Allison Webel, Kenneth H Mayer, Joseph A Delaney, Paul K Crane, Claudia Martinez, Heidi M Crane, Ke Hao, Inga Peter
BACKGROUND: People with human immunodeficiency virus (HIV) infection (PWH) are at higher risk of myocardial infarction (MI) than those without HIV. About half of MIs in PWH are type 2 (T2MI), resulting from mismatch between myocardial oxygen supply and demand, in contrast to type 1 MI (T1MI), which is due to primary plaque rupture or coronary thrombosis. Despite worse survival and rising incidence in the general population, evidence-based treatment recommendations for T2MI are lacking...
May 4, 2023: International Journal of Cardiology
#33
JOURNAL ARTICLE
Christopher L Hallemeier, Jennifer Moughan, Michael G Haddock, Arnold M Herskovic, Bruce D Minsky, Mohan Suntharalingam, Kenneth L Zeitzer, Madhur K Garg, Bruce D Greenwald, Ritsuko U Komaki, Lindsay L Puckett, Hyun Kim, Shane Lloyd, David A Bush, Harold E Kim, Thomas E Lad, Joshua E Meyer, Gordon S Okawara, Adam Raben, Tracey E Schefter, Jerry L Barker, Carla I Falkson, Gregory M M Videtic, Rojymon Jacob, Kathryn A Winter, Christopher H Crane
IMPORTANCE: For many types of epithelial malignant neoplasms that are treated with definitive radiotherapy (RT), treatment prolongation and interruptions have an adverse effect on outcomes. OBJECTIVE: To analyze the association between RT duration and outcomes in patients with esophageal cancer who were treated with definitive chemoradiotherapy (CRT). DESIGN, SETTING, AND PARTICIPANTS: This study was an unplanned, post hoc secondary analysis of 3 prospective, multi-institutional phase 3 randomized clinical trials (Radiation Therapy Oncology Group [RTOG] 8501, RTOG 9405, and RTOG 0436) of the National Cancer Institute-sponsored NRG Oncology (formerly the National Surgical Adjuvant Breast and Bowel Project, RTOG, and Gynecologic Oncology Group)...
April 3, 2023: JAMA Network Open
#34
JOURNAL ARTICLE
Shari D Bolen, Siran Koroukian, Jackson T Wright, Harry Persaud, Douglas Einstadter, Jordan Fiegl, Adam T Perzynski, Douglas Gunzler, Catherine Sullivan, Jonathan Lever, Michael Konstan, Dushka Crane, Allison Lorenz, Michelle Menegay, Doug Spence, Arun RajanBabu, Wendy Groznik, Tonni Oberly, Xiaokun Qian, Christopher R Jordan, Phyllis Virgil, Sinead Yarberry, Emily Saunders, Alice M Teall, Joyce Zurmehly, Melissa Nance, Stephen Albanese, Donald Wharton, Mary S Applegate
Background Hypertension control is critical to reducing cardiovascular disease, challenging to achieve, and exacerbated by socioeconomic inequities. Few states have established statewide quality improvement (QI) infrastructures to improve blood pressure (BP) control across economically disadvantaged populations. In this study, we aimed to improve BP control by 15% for all Medicaid recipients and by 20% for non-Hispanic Black participants. Methodology This QI study used repeated cross-sections of electronic health record data and, for Medicaid enrollees, linked Medicaid claims data for 17,672 adults with hypertension seen at one of eight high-volume Medicaid primary care practices in Ohio from 2017 to 2019...
March 2023: Curēus
#35
JOURNAL ARTICLE
Sara E Cannon, Simon D Donner, Angela Liu, Pedro C González Espinosa, Andrew H Baird, Julia K Baum, Andrew G Bauman, Maria Beger, Cassandra E Benkwitt, Matthew J Birt, Yannick Chancerelle, Joshua E Cinner, Nicole L Crane, Vianney Denis, Martial Depczynski, Nur Fadli, Douglas Fenner, Christopher J Fulton, Yimnang Golbuu, Nicholas A J Graham, James Guest, Hugo B Harrison, Jean-Paul A Hobbs, Andrew S Hoey, Thomas H Holmes, Peter Houk, Fraser A Januchowski-Hartley, Jamaluddin Jompa, Chao-Yang Kuo, Gino Valentino Limmon, Yuting V Lin, Timothy R McClanahan, Dominic Muenzel, Michelle J Paddack, Serge Planes, Morgan S Pratchett, Ben Radford, James Davis Reimer, Zoe T Richards, Claire L Ross, John Rulmal, Brigitte Sommer, Gareth J Williams, Shaun K Wilson
Scientists and managers rely on indicator taxa such as coral and macroalgal cover to evaluate the effects of human disturbance on coral reefs, often assuming a universally positive relationship between local human disturbance and macroalgae. Despite evidence that macroalgae respond to local stressors in diverse ways, there have been few efforts to evaluate relationships between specific macroalgae taxa and local human-driven disturbance. Using genus-level monitoring data from 1205 sites in the Indian and Pacific Oceans, we assess whether macroalgae percent cover correlates with local human disturbance while accounting for factors that could obscure or confound relationships...
April 5, 2023: Global Change Biology
#36
REVIEW
Perla Chami, William Jarnagin, Ghassan K Abou-Alfa, James Harding, Neal Kim, Haibo Lin, Maria El Homsi, Christopher Crane, Carla Hajj
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, representing the third-leading cause of cancer-related deaths worldwide. Curative intent treatment options for patients with HCC include liver transplantation, resection and ablation of small lesions. Other potentially curative therapies include cryoablation, microwave ablation and percutaneous alcohol injection. For locally advanced disease, different arterially directed therapies including transarterial chemoembolization and selective internal radiation therapy, plus external beam radiation including three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, stereotactic body radiation therapy and proton beam therapy, are available or studied...
March 14, 2023: Cancers
#37
JOURNAL ARTICLE
Adam Trickey, Caroline A Sabin, Greer Burkholder, Heidi Crane, Antonella d'Arminio Monforte, Matthias Egger, M John Gill, Sophie Grabar, Jodie L Guest, Inma Jarrin, Fiona C Lampe, Niels Obel, Juliana M Reyes, Christoph Stephan, Timothy R Sterling, Ramon Teira, Giota Touloumi, Jan-Christian Wasmuth, Ferdinand Wit, Linda Wittkop, Robert Zangerle, Michael J Silverberg, Amy Justice, Jonathan A C Sterne
BACKGROUND: The life expectancy of people with HIV taking antiretroviral therapy (ART) has increased substantially over the past 25 years. Most previous studies of life expectancy were based on data from the first few years after starting ART, when mortality is highest. However, many people with HIV have been successfully treated with ART for many years, and up-to-date prognosis data are needed. We aimed to estimate life expectancy in adults with HIV on ART for at least 1 year in Europe and North America from 2015 onwards...
March 20, 2023: Lancet HIV
#38
JOURNAL ARTICLE
Marsha Reyngold, Sana D Karam, Carla Hajj, Abraham J Wu, John Cuaron, Stephanie Lobaugh, Ellen D Yorke, Shannan Dickinson, Bernard Jones, Yevgeniy Vinogradskiy, Amita Shukla-Dave, Richard Kinh Gian Do, Carlie Sigel, Zhigang Zhang, Christopher H Crane, Karyn A Goodman
PURPOSE: The optimal dose and fractionation of stereotactic body radiation therapy (SBRT) for locally advanced pancreatic cancer (LAPC) have not been defined. Single-fraction SBRT was associated with more gastrointestinal toxicity, so 5-fraction regimens have become more commonly employed. We aimed to determine the safety and maximally tolerated dose of 3-fraction SBRT for LAPC. METHODS AND MATERIALS: Two parallel phase 1 dose escalation trials were conducted from 2016 to 2019 at Memorial Sloan Kettering Cancer Center and University of Colorado...
September 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#39
JOURNAL ARTICLE
The vibronic state dependent predissociation of H 2 S: determination of all fragmentation processes.
Yarui Zhao, Junjie Chen, Zijie Luo, Yao Chang, Jiayue Yang, Weiqing Zhang, Guorong Wu, Stuart W Crane, Christopher S Hansen, Hongbin Ding, Feng An, Xixi Hu, Daiqian Xie, Michael N R Ashfold, Kaijun Yuan, Xueming Yang
Photochemistry plays a significant role in shaping the chemical reaction network in the solar nebula and interstellar clouds. However, even in a simple triatomic molecule photodissociation, determination of all fragmentation processes is yet to be achieved. In this work, we present a comprehensive study of the photochemistry of H2 S, derived from cutting-edge translational spectroscopy measurements of the H, S(1 D) and S(1 S) atom products formed by photolysis at wavelengths across the range 155-120 nm. The results provide detailed insights into the energy disposal in the SH( X ), SH( A ) and H2 co-fragments, and the atomisation routes leading to two H atoms along with S(3 P) and S(1 D) atoms...
March 8, 2023: Chemical Science
#40
JOURNAL ARTICLE
Brett L Ecker, Alice J Tao, Quisette P Janssen, Henry S Walch, Colin M Court, Vinod P Balachandran, Christopher H Crane, Michael I D'Angelica, Jeffrey A Drebin, T Peter Kingham, Kevin C Soares, Christine A Iacobuzio-Donahue, Efsevia Vakiani, Mithat Gonen, Eileen M O'Reilly, Anna M Varghese, William R Jarnagin, Alice C Wei
PURPOSE: There is increasing use of neoadjuvant chemotherapy in the management of localized pancreatic ductal adenocarcinoma (PDAC), yet there are few validated biomarkers to guide therapy selection. We aimed to determine whether somatic genomic biomarkers predict response to induction FOLFIRINOX or gemcitabine/nab-paclitaxel. EXPERIMENTAL DESIGN: This single-institution cohort study included consecutive patients (N = 322) with localized PDAC (2011-2020) who received at least one cycle of FOLFIRINOX (N = 271) or gemcitabine/nab-paclitaxel (N = 51) as initial treatment...
April 3, 2023: Clinical Cancer Research
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