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https://www.readbyqxmd.com/read/28355443/the-use-of-metabolomics-to-identify-biological-signatures-of-manganese-exposure
#1
Marissa G Baker, Christopher D Simpson, Yvonne S Lin, Laura M Shireman, Noah Seixas
Objectives: Manganese (Mn) is a known neurotoxicant, and given its health effects and ubiquitous nature in metal-working settings, identification of a valid and reproducible biomarker of Mn exposure is of interest. Here, global metabolomics is utilized to determine metabolites that differ between groups defined by Mn exposure status, with the goal being to help inform a potential metabolite biomarker of Mn exposure. Methods: Mn exposed subjects were recruited from a Mn steel foundry and Mn unexposed subjects were recruited from crane operators at a metal recycling facility...
May 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28355222/transaldolase-inhibition-impairs-mitochondrial-respiration-and-induces-a-starvation-like-longevity-response-in-caenorhabditis-elegans
#2
Christopher F Bennett, Jane J Kwon, Christine Chen, Joshua Russell, Kathlyn Acosta, Nikolay Burnaevskiy, Matthew M Crane, Alessandro Bitto, Helen Vander Wende, Marissa Simko, Victor Pineda, Ryan Rossner, Brian M Wasko, Haeri Choi, Shiwen Chen, Shirley Park, Gholamali Jafari, Bryan Sands, Carissa Perez Olsen, Alexander R Mendenhall, Philip G Morgan, Matt Kaeberlein
Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously, we determined that decreased expression of the cytosolic pentose phosphate pathway (PPP) enzyme transaldolase activates the mitochondrial unfolded protein response (UPRmt) and extends lifespan. Here we report that transaldolase (tald-1) deficiency impairs mitochondrial function in vivo, as evidenced by altered mitochondrial morphology, decreased respiration, and increased cellular H2O2 levels...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28285434/prevalence-and-factors-associated-with-hazardous-alcohol-use-among-persons-living-with-hiv-across-the-us-in-the-current-era-of-antiretroviral-treatment
#3
Heidi M Crane, Mary E McCaul, Geetanjali Chander, Heidi Hutton, Robin M Nance, Joseph A C Delaney, Joseph O Merrill, Bryan Lau, Kenneth H Mayer, Michael J Mugavero, Matthew Mimiaga, James H Willig, Greer A Burkholder, Daniel R Drozd, Rob J Fredericksen, Karen Cropsey, Richard D Moore, Jane M Simoni, W Christopher Mathews, Joseph J Eron, Sonia Napravnik, Katerina Christopoulos, Elvin Geng, Michael S Saag, Mari M Kitahata
Hazardous alcohol use is associated with detrimental health outcomes among persons living with HIV (PLWH). We examined the prevalence and factors associated with hazardous alcohol use in the current era using several hazardous drinking definitions and binge drinking defined as ≥5 drinks for men versus ≥4 for women. We included 8567 PLWH from 7 U.S. sites from 2013 to 2015. Current hazardous alcohol use was reported by 27% and 34% reported binge drinking. In adjusted analyses, current and past cocaine/crack (odd ratio [OR] 4...
March 11, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28244956/relationship-between-ever-reporting-depressive-symptoms-and-all-cause-mortality-in-a-cohort-of-hiv-infected-adults-in-routine-care
#4
Angela M Bengtson, Brian W Pence, Richard Moore, Matthew J Mimiaga, William Christopher Mathews, Amy Heine, Bradley N Gaynes, Sonia Napravnik, Katerina Christopoulos, Heidi M Crane, Michael J Mugavero
OBJECTIVE: The aim of this study was to assess whether ever reporting depressive symptoms affects mortality in the modern HIV treatment era. DESIGN: A cohort study of HIV-infected adults in routine clinical care at seven sites in the USA. METHODS: We examined the effect of ever reporting depressive symptoms on all-cause mortality using data from the Centers for AIDS Research Network of Integrated Clinical Systems cohort. We included individuals with at least one depression measure between 2005 and 2014...
April 24, 2017: AIDS
https://www.readbyqxmd.com/read/28199763/disseminated-cat-scratch-disease-presenting-as-nausea-diarrhea-and-weight-loss-without-fever-in-a-heart-transplant-recipient
#5
Annukka A R Antar, Amit Goyal, Karly Murphy, Matthew Schimmel, Nisha A Gilotra, Isabella Martin, Genevieve Marie Crane, Christopher Sciortino, Robin K Avery, Brian A Houston
We report the case of an afebrile 59-year-old heart transplant recipient presenting with nausea, vomiting, diarrhea, weight loss, and diffuse lymphadenopathy. Lymph node biopsies revealed non-caseating granulomatous inflammation. Cat-scratch disease was confirmed by serologic studies, Warthin-Starry staining, and polymerase chain reaction testing of lymph node tissue. The patient's symptoms resolved with 3 months of doxycycline. We review clinical presentations of Bartonella henselae infection in and review diagnostic approaches for B...
February 15, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28126304/significance-of-co-expression-of-epidermal-growth-factor-receptor-and-ki67-on-clinical-outcome-in-patients-with-anal-cancer-treated-with-chemoradiotherapy-an-analysis-of-nrg-oncology-rtog-9811
#6
Corinne M Doll, Jennifer Moughan, Alexander Klimowicz, Clement K Ho, Elizabeth N Kornaga, Susan P Lees-Miller, Jaffer A Ajani, Christopher H Crane, Lisa A Kachnic, Gordon S Okawara, Lawrence B Berk, Kevin S Roof, Mark J Becker, David L Grisell, Robert J Ellis, Paul W Sperduto, Gerald W Marsa, Chandan Guha, Anthony M Magliocco
PURPOSE: To measure co-expression of EGFR and Ki67 proteins in pretreatment tumor biopsies of anal cancer patients enrolled on NRG Oncology RTOG 9811, a phase III trial comparing 5-fluorouracil/mitomycin-C/radiation therapy (Arm A) versus 5-fluorouracil/cisplatin/radiation therapy (Arm B), and to correlate expression with clinical outcome. METHODS AND MATERIALS: EGFR and Ki67 co-expression was measured after constructing a tissue microarray using fluorescence immunohistochemistry and automated quantitative image analysis...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28125593/mind-the-gap-gaps-in-antidepressant-treatment-treatment-adjustments-and-outcomes-among-patients-in-routine-hiv-care-in-a-multisite-u-s-clinical-cohort
#7
Rushina Cholera, Brian W Pence, Angela M Bengtson, Heidi M Crane, Katerina Christopoulos, Steven R Cole, Rob Fredericksen, Bradley N Gaynes, Amy Heine, W Christopher Mathews, Matthew J Mimiaga, Richard Moore, Sonia Napravnik, Conall O'Clerigh, Steven Safren, Michael J Mugavero
BACKGROUND: Depression affects 20-30% of HIV-infected patients and is associated with worse HIV outcomes. Although effective depression treatment is available, depression is largely untreated or undertreated in this population. METHODS: We quantified gaps in antidepressant treatment, treatment adjustments, and outcomes among US patients in routine HIV care in the nationally distributed CNICS observational clinical cohort. This cohort combines detailed clinical data with regular, self-reported depressive severity assessments (Patient Health Questionnaire-9, PHQ-9)...
2017: PloS One
https://www.readbyqxmd.com/read/28081563/interactions-with-astroglia-influence-the-shape-of-the-developing-dendritic-arbor-and-restrict-dendrite-growth-independent-of-promoting-synaptic-contacts
#8
Ginger S Withers, Jennifer R Farley, Jeffrey R Sterritt, Andrés B Crane, Christopher S Wallace
Astroglia play key roles in the development of neurons, ranging from regulating neuron survival to promoting synapse formation, yet basic questions remain about whether astrocytes might be involved in forming the dendritic arbor. Here, we used cultured hippocampal neurons as a simple in vitro model that allowed dendritic growth and geometry to be analyzed quantitatively under conditions where the extent of interactions between neurons and astrocytes varied. When astroglia were proximal to neurons, dendrites and dendritic filopodia oriented toward them, but the general presence of astroglia significantly reduced overall dendrite growth...
2017: PloS One
https://www.readbyqxmd.com/read/28068240/does-unintentional-splenic-radiation-predict-outcomes-after-pancreatic-cancer-radiation-therapy
#9
Awalpreet S Chadha, Guan Liu, Hsiang-Chun Chen, Prajnan Das, Bruce D Minsky, Usama Mahmood, Marc E Delclos, Yelin Suh, Gabriel O Sawakuchi, Sam Beddar, Matthew H Katz, Jason B Fleming, Milind M Javle, Gauri R Varadhachary, Robert A Wolff, Christopher H Crane, Xuemei Wang, Howard Thames, Sunil Krishnan
PURPOSE: To determine whether severity of lymphopenia is dependent on radiation dose and fractional volume of spleen irradiated unintentionally during definitive chemoradiation (CRT) in patients with locally advanced pancreatic cancer (LAPC). METHODS: 177 patients with LAPC received induction chemotherapy (mainly gemcitabine-based regimens) followed by CRT (median 50.4 Gy with concurrent capecitabine) from January 2006 to December 2012. Absolute lymphocyte count (ALC) was recorded at baseline, before CRT, and 2 to 10 weeks after CRT...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28057329/hyperfractionated-accelerated-reirradiation-for-rectal-cancer-an-analysis-of-outcomes-and-toxicity
#10
Randa Tao, Chiaojung Jillian Tsai, Garrett Jensen, Cathy Eng, Scott Kopetz, Michael J Overman, John M Skibber, Miguel Rodriguez-Bigas, George J Chang, Yi-Qian Nancy You, Brian K Bednarski, Bruce D Minsky, Marc E Delclos, Eugene Koay, Sunil Krishnan, Christopher H Crane, Prajnan Das
BACKGROUND AND PURPOSE: To evaluate outcomes and toxicity in patients treated with hyperfractionated pelvic reirradiation for recurrent rectal cancer. MATERIALS AND METHODS: 102 patients with recurrent rectal adenocarcinoma were treated with pelvic reirradiation with a hyperfractionated accelerated approach, consisting of 1.5Gy twice daily fractions to a total dose of 30-45Gy (median 39Gy), with the most common total dose 39Gy (n=90, 88%). The median dose of prior pelvic radiation therapy (RT) was 50...
January 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28006972/identifying-hiv-care-enrollees-at-risk-for-cannabis-use-disorder
#11
Bryan Hartzler, Beatriz H Carlini, Howard Newville, Heidi M Crane, Joseph J Eron, Elvin H Geng, W Christopher Mathews, Kenneth H Mayer, Richard D Moore, Michael J Mugavero, Sonia Napravnik, Benigno Rodriguez, Dennis M Donovan
Increased scientific attention given to cannabis in the United States has particular relevance for its domestic HIV care population, given that evidence exists for both cannabis as a therapeutic agent and cannabis use disorder (CUD) as a barrier to antiretroviral medication adherence. It is critical to identify relative risk for CUD among demographic subgroups of HIV patients, as this will inform detection and intervention efforts. A Center For AIDS Research Network of Integrated Clinical Systems cohort (N = 10,652) of HIV-positive adults linked to care at seven United State sites was examined for this purpose...
December 23, 2016: AIDS Care
https://www.readbyqxmd.com/read/27998625/a-consensus-driven-agenda-for-emergency-medicine-firearm-injury-prevention-research
#12
Megan L Ranney, Jonathan Fletcher, Harrison Alter, Christopher Barsotti, Vikhyat S Bebarta, Marian E Betz, Patrick M Carter, Magdalena Cerdá, Rebecca M Cunningham, Peter Crane, Jahan Fahimi, Matthew J Miller, Ali Rowhani-Rahbar, Jody A Vogel, Garen J Wintemute, Muhammad Waseem, Manish N Shah
STUDY OBJECTIVE: To identify critical emergency medicine-focused firearm injury research questions and develop an evidence-based research agenda. METHODS: National content experts were recruited to a technical advisory group for the American College of Emergency Physicians Research Committee. Nominal group technique was used to identify research questions by consensus. The technical advisory group decided to focus on 5 widely accepted categorizations of firearm injury...
February 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27988776/-i-alloionema-i-i-californicum-i-n-sp-nematoda-alloionematidae-a-new-alloionematid-from-usa
#13
Jiří Nermuť, Vladimír Půža, Zdeněk Mráček, Edwin Lewis
A new species of the family Alloionematidae was isolated from a rotten winged gourd at White Crane Garden, San Francisco, USA, sampled by Christopher Nelson in November 2010, and a live culture is deposited in Félix Lab Strain Database (http://www.justbio.com/worms/index.php), IBENS, Paris, France. Specimens from the culture have been examined. Both morphologically and molecularly, the nematode described herein as Alloionema californicum n. sp. differs from the other alloionematid species, A. appendiculatum and Neoalloionema tricaudatum...
November 7, 2016: Zootaxa
https://www.readbyqxmd.com/read/27984655/local-therapy-reduces-the-risk-of-liver-failure-and-improves-survival-in-patients-with-intrahepatic-cholangiocarcinoma-a-comprehensive-analysis-of-362-consecutive-patients
#14
Suguru Yamashita, Eugene Jon Koay, Guillaume Passot, Rachna Shroff, Kanwal P Raghav, Claudius Conrad, Yun Shin Chun, Thomas A Aloia, Randa Tao, Ahmed Kaseb, Milind Javle, Christopher H Crane, Jean-Nicolas Vauthey
BACKGROUND: Treatment methods for intrahepatic cholangiocarcinoma (ICC) have improved, but their impact on outcome remains unclear. We evaluated the outcomes of patients definitively treated with resection, radiation, and chemotherapy for ICC, stratified by era. METHODS: Clinico-pathologic characteristics, cause of death, disease-specific survival (DSS), and intrahepatic progression-free survival (IPFS) were compared among patients who underwent resection, radiation, or chemotherapy as definitive treatment strategies for ICC (without distant organ metastasis) between 1997 and 2015...
April 15, 2017: Cancer
https://www.readbyqxmd.com/read/27796417/enthalpy-entropy-compensation-the-role-of-solvation
#15
REVIEW
Anatoliy I Dragan, Christopher M Read, Colyn Crane-Robinson
Structural modifications to interacting systems frequently lead to changes in both the enthalpy (heat) and entropy of the process that compensate each other, so that the Gibbs free energy is little changed: a major barrier to the development of lead compounds in drug discovery. The conventional explanation for such enthalpy-entropy compensation (EEC) is that tighter contacts lead to a more negative enthalpy but increased molecular constraints, i.e., a compensating conformational entropy reduction. Changes in solvation can also contribute to EEC but this contribution is infrequently discussed...
May 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/27778257/preoperative-therapy-and-pancreatoduodenectomy-for-pancreatic-ductal-adenocarcinoma-a-25-year-single-institution-experience
#16
Jordan M Cloyd, Matthew H G Katz, Laura Prakash, Gauri R Varadhachary, Robert A Wolff, Rachna T Shroff, Milind Javle, David Fogelman, Michael Overman, Christopher H Crane, Eugene J Koay, Prajnan Das, Sunil Krishnan, Bruce D Minsky, Jeffrey H Lee, Manoop S Bhutani, Brian Weston, William Ross, Priya Bhosale, Eric P Tamm, Huamin Wang, Anirban Maitra, Michael P Kim, Thomas A Aloia, Jean-Nicholas Vauthey, Jason B Fleming, James L Abbruzzese, Peter W T Pisters, Douglas B Evans, Jeffrey E Lee
BACKGROUND: The purpose of this study was to evaluate a single-institution experience with delivery of preoperative therapy to patients with pancreatic ductal adenocarcinoma (PDAC) prior to pancreatoduodenectomy (PD). METHODS: Consecutive patients (622) with PDAC who underwent PD following chemotherapy and/or chemoradiation between 1990 and 2014 were retrospectively reviewed. Preoperative treatment regimens, clinicopathologic characteristics, operative details, and long-term outcomes in four successive time periods (1990-1999, 2000-2004, 2005-2009, 2010-2014) were evaluated and compared...
January 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27755060/hyperfractionated-accelerated-reirradiation-for-patients-with-recurrent-anal-cancer-previously-treated-with-definitive-chemoradiation
#17
Eleanor M Osborne, Cathy Eng, John M Skibber, Miguel A Rodriguez-Bigas, George J Chang, Yi-Qian Nancy You, Brian K Bednarski, Bruce D Minsky, Marc E Delclos, Eugene Koay, Sunil Krishnan, Christopher H Crane, Prajnan Das
OBJECTIVES: Although chemoradiation is the standard of care for anal cancer, limited data exist regarding pelvic reirradiation (re-RT) for recurrent disease. We investigated toxicity and outcomes in patients who received prior pelvic radiation therapy (RT), and subsequently underwent hyperfractionated accelerated re-RT to the pelvis for recurrent anal cancer. MATERIALS AND METHODS: We reviewed records of 10 patients with recurrent anal squamous cell carcinoma who previously received pelvic RT to at least 30 Gy as a component of their chemoradiation and underwent re-RT in 1...
October 17, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27738780/prevalence-and-predictors-of-substance-use-disorders-among-hiv-care-enrollees-in-the-united-states
#18
Bryan Hartzler, Julia C Dombrowski, Heidi M Crane, Joseph J Eron, Elvin H Geng, W Christopher Mathews, Kenneth H Mayer, Richard D Moore, Michael J Mugavero, Sonia Napravnik, Benigno Rodriguez, Dennis M Donovan
Prior efforts to estimate U.S. prevalence of substance use disorders (SUDs) in HIV care have been undermined by caveats common to single-site trials. The current work reports on a cohort of 10,652 HIV-positive adults linked to care at seven sites, with available patient data including geography, demography, and risk factor indices, and with substance-specific SUDs identified via self-report instruments with validated diagnostic thresholds. Generalized estimating equations also tested patient indices as SUD predictors...
April 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/27730398/preoperative-chemoradiation-for-pancreatic-adenocarcinoma-does-not-increase-90-day-postoperative-morbidity-or-mortality
#19
Jason W Denbo, Morgan L Bruno, Jordan M Cloyd, Laura Prakash, Jeffrey E Lee, Michael Kim, Christopher H Crane, Eugene J Koay, Sunil Krishnan, Prajnan Das, Bruce D Minsky, Gauri Varadhachary, Rachna Shroff, Robert Wolff, Milind Javle, Michael J Overman, David Fogelman, Thomas A Aloia, Jean-Nicolas Vauthey, Jason B Fleming, Matthew H G Katz
BACKGROUND: The impact of preoperative chemoradiation on postoperative morbidity and mortality of patients with pancreatic adenocarcinoma remains controversial. METHODS: Consecutive pancreatectomies for adenocarcinoma performed between 2011 and 2015 were prospectively monitored for 90 days by using a previously reported surveillance system to determine the association between preoperative chemoradiation and adverse events, pancreatic fistulae, readmissions, and mortality...
October 11, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27685855/tumor-infiltrating-macrophages-in-post-transplant-relapsed-classical-hodgkin-lymphoma-are-donor-derived
#20
Genevieve M Crane, Mark A Samols, Laura A Morsberger, Raluca Yonescu, Michele L Thiess, Denise A S Batista, Yi Ning, Kathleen H Burns, Milena Vuica-Ross, Michael J Borowitz, Christopher D Gocke, Richard F Ambinder, Amy S Duffield
Tumor-associated inflammatory cells in classical Hodgkin lymphoma (CHL) typically outnumber the neoplastic Hodgkin/Reed-Sternberg (H/RS) cells. The composition of the inflammatory infiltrate, particularly the fraction of macrophages, has been associated with clinical behavior. Emerging work from animal models demonstrates that most tissue macrophages are maintained by a process of self-renewal under physiologic circumstances and certain inflammatory states, but the contribution from circulating monocytes may be increased in some disease states...
2016: PloS One
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