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Christopher crane

Anatoliy I Dragan, Christopher M Read, Colyn Crane-Robinson
Structural modifications to interacting systems frequently lead to changes in both the enthalpy (heat) and entropy of the process that compensate each other, so that the Gibbs free energy is little changed: a major barrier to the development of lead compounds in drug discovery. The conventional explanation for such enthalpy-entropy compensation (EEC) is that tighter contacts lead to a more negative enthalpy but increased molecular constraints, i.e., a compensating conformational entropy reduction. Changes in solvation can also contribute to EEC but this contribution is infrequently discussed...
October 28, 2016: European Biophysics Journal: EBJ
Jordan M Cloyd, Matthew H G Katz, Laura Prakash, Gauri R Varadhachary, Robert A Wolff, Rachna T Shroff, Milind Javle, David Fogelman, Michael Overman, Christopher H Crane, Eugene J Koay, Prajnan Das, Sunil Krishnan, Bruce D Minsky, Jeffrey H Lee, Manoop S Bhutani, Brian Weston, William Ross, Priya Bhosale, Eric P Tamm, Huamin Wang, Anirban Maitra, Michael P Kim, Thomas A Aloia, Jean-Nicholas Vauthey, Jason B Fleming, James L Abbruzzese, Peter W T Pisters, Douglas B Evans, Jeffrey E Lee
BACKGROUND: The purpose of this study was to evaluate a single-institution experience with delivery of preoperative therapy to patients with pancreatic ductal adenocarcinoma (PDAC) prior to pancreatoduodenectomy (PD). METHODS: Consecutive patients (622) with PDAC who underwent PD following chemotherapy and/or chemoradiation between 1990 and 2014 were retrospectively reviewed. Preoperative treatment regimens, clinicopathologic characteristics, operative details, and long-term outcomes in four successive time periods (1990-1999, 2000-2004, 2005-2009, 2010-2014) were evaluated and compared...
October 24, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Eleanor M Osborne, Cathy Eng, John M Skibber, Miguel A Rodriguez-Bigas, George J Chang, Yi-Qian Nancy You, Brian K Bednarski, Bruce D Minsky, Marc E Delclos, Eugene Koay, Sunil Krishnan, Christopher H Crane, Prajnan Das
OBJECTIVES: Although chemoradiation is the standard of care for anal cancer, limited data exist regarding pelvic reirradiation (re-RT) for recurrent disease. We investigated toxicity and outcomes in patients who received prior pelvic radiation therapy (RT), and subsequently underwent hyperfractionated accelerated re-RT to the pelvis for recurrent anal cancer. MATERIALS AND METHODS: We reviewed records of 10 patients with recurrent anal squamous cell carcinoma who previously received pelvic RT to at least 30 Gy as a component of their chemoradiation and underwent re-RT in 1...
October 17, 2016: American Journal of Clinical Oncology
Bryan Hartzler, Julia C Dombrowski, Heidi M Crane, Joseph J Eron, Elvin H Geng, W Christopher Mathews, Kenneth H Mayer, Richard D Moore, Michael J Mugavero, Sonia Napravnik, Benigno Rodriguez, Dennis M Donovan
Prior efforts to estimate U.S. prevalence of substance use disorders (SUDs) in HIV care have been undermined by caveats common to single-site trials. The current work reports on a cohort of 10,652 HIV-positive adults linked to care at seven sites, with available patient data including geography, demography, and risk factor indices, and with substance-specific SUDs identified via self-report instruments with validated diagnostic thresholds. Generalized estimating equations also tested patient indices as SUD predictors...
October 13, 2016: AIDS and Behavior
Jason W Denbo, Morgan L Bruno, Jordan M Cloyd, Laura Prakash, Jeffrey E Lee, Michael Kim, Christopher H Crane, Eugene J Koay, Sunil Krishnan, Prajnan Das, Bruce D Minsky, Gauri Varadhachary, Rachna Shroff, Robert Wolff, Milind Javle, Michael J Overman, David Fogelman, Thomas A Aloia, Jean-Nicolas Vauthey, Jason B Fleming, Matthew H G Katz
BACKGROUND: The impact of preoperative chemoradiation on postoperative morbidity and mortality of patients with pancreatic adenocarcinoma remains controversial. METHODS: Consecutive pancreatectomies for adenocarcinoma performed between 2011 and 2015 were prospectively monitored for 90 days by using a previously reported surveillance system to determine the association between preoperative chemoradiation and adverse events, pancreatic fistulae, readmissions, and mortality...
October 11, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Genevieve M Crane, Mark A Samols, Laura A Morsberger, Raluca Yonescu, Michele L Thiess, Denise A S Batista, Yi Ning, Kathleen H Burns, Milena Vuica-Ross, Michael J Borowitz, Christopher D Gocke, Richard F Ambinder, Amy S Duffield
Tumor-associated inflammatory cells in classical Hodgkin lymphoma (CHL) typically outnumber the neoplastic Hodgkin/Reed-Sternberg (H/RS) cells. The composition of the inflammatory infiltrate, particularly the fraction of macrophages, has been associated with clinical behavior. Emerging work from animal models demonstrates that most tissue macrophages are maintained by a process of self-renewal under physiologic circumstances and certain inflammatory states, but the contribution from circulating monocytes may be increased in some disease states...
2016: PloS One
Angela M Bengtson, Brian W Pence, Bradley N Gaynes, E Byrd Quinlivan, Amy D Heine, Julie K OʼDonnell, Heidi M Crane, W Christopher Mathews, Richard D Moore, Daniel Westreich, Conall OʼCleirigh, Katerina Christopoulos, Matthew J Mimiaga, Michael J Mugavero
BACKGROUND: Depression affects 20%-30% of people with HIV. Randomized controlled trials (RCTs) have demonstrated the effectiveness of interventions to improve depression among HIV-infected adults, but typically have highly selected populations which may limit generalizability. Inverse probability of sampling weights (IPSW) is a recently proposed method to transport (or standardize) findings from RCTs to a specific external target population. METHODS: We used IPSW to transport the 6-month effect of the Measurement-Based Care (MBC) intervention on depression from the SLAM DUNC trial to a population of HIV-infected, depressed adults in routine care in the United States between 2010 and 2014...
December 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Cameron W Swanick, Pamela K Allen, Randa Tao, Adenike M Olanrewaju, Jordan R Sutton, Steven H Lin, James Welsh, Prajnan Das, Joe Y Chang, Christopher H Crane, Daniel R Gomez
PURPOSE: Fifteen fraction treatment schedules are increasingly used to deliver high doses of radiation therapy (RT) to both lung and hepatobiliary malignancies. The purpose of our study was to examine the incidence and predictors of chest wall (CW) toxicity in patients treated with this regimen. METHODS AND MATERIALS: We evaluated 135 patients treated with RT to doses ≥52.5 Gy in 15 fractions for thoracic and hepatobiliary malignancies between January 2009 and December 2012...
June 3, 2016: Practical Radiation Oncology
Alex de Voux, James B Kent, Kathryn Macomber, Karen Krzanowski, Dawn Jackson, Tayneata Starr, Sandra Johnson, Deborah Richmond, Lawrence R Crane, Jonathan Cohn, Christopher Finch, Jevon McFadden, Allan Pillay, Cheng Chen, Laurie Anderson, Ellen N Kersh
Lymphogranuloma venereum (LGV) is a sexually transmitted disease (STD) caused by infection with invasive Chlamydia trachomatis serovars L1-L3 (1). LGV is characterized by inguinal and/or femoral lymphadenopathy, typically following a transient, self-limited genital ulcer or papule that might go unnoticed. Rectal infection can result in proctocolitis that can present with mucoid and/or hemorrhagic rectal discharge, anal pain, constipation, fever, and tenesmus, and signs of granulomas and/or ulcerations on anoscopy (1,2)...
2016: MMWR. Morbidity and Mortality Weekly Report
Brennan K Smith, Rebecca J Ford, Eric M Desjardins, Alex E Green, Meghan C Hughes, Vanessa P Houde, Emily A Day, Katarina Marcinko, Justin D Crane, Emilio P Mottillo, Christopher G R Perry, Bruce E Kemp, Mark A Tarnopolsky, Gregory R Steinberg
Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces non-alcoholic fatty liver disease (NAFLD) in animal models; however, the mechanism mediating these effects is unclear. Salicylate directly activates AMP-activated protein kinase (AMPK) via the β1 subunit but whether salsalate requires AMPK β1 to improve T2D and NAFLD has not been examined. Therefore, wild-type (WT) and AMPK β1 knockout mice (AMPK β1KO) were treated with a salsalate dose resulting in clinically relevant serum salicylate concentrations (∼1 mM)...
August 23, 2016: Diabetes
Emma B Holliday, Cameron W Swanick, Sarah A McAvoy, Gary V Walker, Christopher H Crane, Anita Mahajan, Prajnan Das
No abstract text is available yet for this article.
August 20, 2016: Journal of the American College of Radiology: JACR
Adam Trickey, Margaret T May, Janne Vehreschild, Niels Obel, Michael John Gill, Heidi Crane, Christoph Boesecke, Hasina Samji, Sophie Grabar, Charles Cazanave, Matthias Cavassini, Leah Shepherd, Antonella d'Arminio Monforte, Colette Smit, Michael Saag, Fiona Lampe, Vicky Hernando, Marta Montero, Robert Zangerle, Amy C Justice, Timothy Sterling, Jose Miro, Suzanne Ingle, Jonathan A C Sterne
OBJECTIVES: To estimate mortality rates and prognostic factors in HIV-positive patients who started combination antiretroviral therapy between 1996-1999 and survived for more than ten years. METHODS: We used data from 18 European and North American HIV cohort studies contributing to the Antiretroviral Therapy Cohort Collaboration. We followed up patients from ten years after start of combination antiretroviral therapy. We estimated overall and cause-specific mortality rate ratios for age, sex, transmission through injection drug use, AIDS, CD4 count and HIV-1 RNA...
2016: PloS One
Angela M Bengtson, Brian W Pence, Heidi M Crane, Katerina Christopoulos, Rob J Fredericksen, Bradley N Gaynes, Amy Heine, W Christopher Mathews, Richard Moore, Sonia Napravnik, Steven Safren, Michael J Mugavero
OBJECTIVE: To describe disparities along the depression treatment cascade, from indication for antidepressant treatment to effective treatment, in HIV-infected individuals by gender and race/ethnicity. METHODS: The Center for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) cohort includes 31,000 HIV-infected adults in routine clinical care at 8 sites. Individuals were included in the analysis if they had a depressive symptoms measure within one month of establishing HIV care at a CNICS site...
2016: PloS One
Christopher J Bungard, Peter D Williams, Jeanine E Ballard, David J Bennett, Christian Beaulieu, Carolyn Bahnck-Teets, Steve S Carroll, Ronald K Chang, David C Dubost, John F Fay, Tracy L Diamond, Thomas J Greshock, Li Hao, M Katharine Holloway, Peter J Felock, Jennifer J Gesell, Hua-Poo Su, Jesse J Manikowski, Daniel J McKay, Mike Miller, Xu Min, Carmela Molinaro, Oscar M Moradei, Philippe G Nantermet, Christian Nadeau, Rosa I Sanchez, Tummanapalli Satyanarayana, William D Shipe, Sanjay K Singh, Vouy Linh Truong, Sivalenka Vijayasaradhi, Catherine M Wiscount, Joseph P Vacca, Sheldon N Crane, John A McCauley
A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Analysis of the crystal structure of the initial lead bound to HIV protease enabled optimization of enzyme potency and antiviral activity. This afforded a series of potent orally bioavailable inhibitors of which MK-8718 was identified as a compound with a favorable overall profile.
July 14, 2016: ACS Medicinal Chemistry Letters
Jieying Jiang, Nikolina Icitovic, Michael A Crane, Christopher R Dasaro, Julia R Kaplan, Roberto G Lucchini, Benjamin J Luft, Jacqueline M Moline, Lakshmi Pendem, Moshe Shapiro, Iris G Udasin, Andrew C Todd, Susan L Teitelbaum
BACKGROUND: Asthma and gastroesophageal reflux disease (GERD) are two common conditions among the responders to the WTC attacks. This study examined whether the cumulative incidence rates of asthma and GERD differed by sex among 24,022 and 23,557 WTC responders, respectively. METHODS: Cox proportional hazards regression was used to examine the sex difference in the rate of onset of physician-diagnosed asthma or GERD, from 9/12/2001 through 12/31/2015. RESULTS: The cumulative incidence of asthma reached 23% for women and 17% for men by the end of 2015, and the cumulative incidence of GERD reached 45% for women and 38% for men...
September 2016: American Journal of Industrial Medicine
Marta Penna, Brendan Moran, Sarah Crane, Roel Hompes, Christopher Cunningham
Publication of surgical activity and mortality was first introduced in the United Kingdom (UK) in 2004 for adult cardiac surgery. The Kennedy Inquiry into paediatric cardiac deaths at the Bristol Royal Infirmary [1] motivated this initiative. The Freedom of Information Act in 2005 and the Francis Report [2] which appeared in 2012 led to the NHS Commissioning Board's document "Everybody Counts" [3]. This article is protected by copyright. All rights reserved.
June 25, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Awalpreet S Chadha, Heath D Skinner, Jillian R Gunther, Mark F Munsell, Prajnan Das, Bruce D Minsky, Marc E Delclos, Deyali Chatterjee, Huamin Wang, Marilyn Clemons, Geena George, Pankaj K Singh, Matthew H Katz, Jason B Fleming, Milind M Javle, Robert A Wolff, Gauri R Varadhachary, Christopher H Crane, Sunil Krishnan
PURPOSE: To determine the safety, tolerability and maximum tolerated dose (MTD) of addition of erlotinib to bevacizumab and capecitabine-based definitive chemoradiation (CRT) in unresectable pancreatic cancer. METHODS: Seventeen patients with CT-staged, biopsy-proven unresectable pancreatic cancer were enrolled between 3/2008 and 10/2010. Prior chemotherapy was permitted. Two patients each were enrolled at dose levels (DLs) 1-4 and 9 patients at DL 5. All patients received 50...
2016: PloS One
Davendra P S Sohal, Pamela B Mangu, Alok A Khorana, Manish A Shah, Philip A Philip, Eileen M O'Reilly, Hope E Uronis, Ramesh K Ramanathan, Christopher H Crane, Anitra Engebretson, Joseph T Ruggiero, Mehmet S Copur, Michelle Lau, Susan Urba, Daniel Laheru
PURPOSE: To provide evidence-based recommendations to oncologists and others for the treatment of patients with metastatic pancreatic cancer. METHODS: American Society of Clinical Oncology convened an Expert Panel of medical oncology, radiation oncology, surgical oncology, gastroenterology, palliative care, and advocacy experts to conduct a systematic review of the literature from April 2004 to June 2015. Outcomes were overall survival, disease-free survival, progression-free survival, and adverse events...
August 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Edward P Balaban, Pamela B Mangu, Alok A Khorana, Manish A Shah, Somnath Mukherjee, Christopher H Crane, Milind M Javle, Jennifer R Eads, Peter Allen, Andrew H Ko, Anitra Engebretson, Joseph M Herman, John H Strickler, Al B Benson, Susan Urba, Nelson S Yee
PURPOSE: To provide evidence-based recommendations to oncologists and others for treatment of patients with locally advanced, unresectable pancreatic cancer. METHODS: American Society of Clinical Oncology convened an Expert Panel of medical oncology, radiation oncology, surgical oncology, gastroenterology, palliative care, and advocacy experts and conducted a systematic review of the literature from January 2002 to June 2015. Outcomes included overall survival, disease-free survival, progression-free survival, and adverse events...
August 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Jordan M Cloyd, Christopher H Crane, Eugene J Koay, Prajnan Das, Sunil Krishnan, Laura Prakash, Rebecca A Snyder, Gauri R Varadhachary, Robert A Wolff, Milind Javle, Rachna T Shroff, David Fogelman, Michael Overman, Huamin Wang, Anirban Maitra, Jeffrey E Lee, Jason B Fleming, Matthew H G Katz
BACKGROUND: Previous studies have suggested that preoperative chemoradiation (CRT) is associated with an improved margin-negative resection rate among patients who undergo pancreatoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC). However, the optimal preoperative regimen has not been established. METHODS: All patients with PDAC who received chemotherapy and/or CRT followed by PD between 1999 and 2014 were retrospectively reviewed. The effects of 2 external-beam radiation regimens-a standard course of 50...
September 1, 2016: Cancer
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