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JOURNAL ARTICLE
Marion Lartigau, Eric Ouattara, Camille Tumiotto, Harald Wodrich, Laurent Busson, Pascale Trimoulet, Elise Thiel, Mahissata Nouzille, Maria Dubos, Marie-Edith Lafon, Véronique Gilleron, Patrick Dehail, Nathalie Salles, Denis Malvy
OBJECTIVE: To describe COVID-19 breakthrough infections in two nursing homes (NHs) sites of active COVID-19 clusters despite optimal vaccination coverage. METHODS: A cross-sectional study was conducted in two NHs of south-western France, following the investigation of COVID-19 clusters (February-March 2021). SARS-CoV-2-confirmed infection was defined by positive RT-PCR. Antibodies neutralization capacities were tested in a subgroup of fully-vaccinated and seropositive-residents...
March 15, 2022: Journal of Clinical Virology
#22
EDITORIAL
Jens Overgaard, Marianne C Aznar, Carol Bacchus, Rob P Coppes, Eric Deutsch, Dietmar Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F Lartigau, Anne W M Lee, Steffen Löck, Birgitte V Offersen, David I Thwaites, Albert J van der Kogel, Uulke A van der Heide, Vincenzo Valentini, Michael Baumann
No abstract text is available yet for this article.
January 17, 2022: Radiotherapy and Oncology
#23
REVIEW
Andria Rakotomalala, Alexandre Escande, Alessandro Furlan, Samuel Meignan, Eric Lartigau
Radiotherapy is an important component of cancer treatment, with approximately 50% of all cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid tumors frequently exhibit hypoxic areas, which can hinder therapies efficacy, especially radiotherapy one. Indeed, hypoxia impacts the six parameters governing the radiotherapy response, called the « six Rs of radiation biology » (for Radiosensitivity, Repair, Repopulation, Redistribution, Reoxygenation, and Reactivation of anti-tumor immune response), by inducing pleiotropic cellular adaptions, such as cell metabolism rewiring, epigenetic landscape remodeling, and cell death weakening, with significant clinical repercussions...
2021: Frontiers in Endocrinology
#24
JOURNAL ARTICLE
Igor Latorzeff, Eric Bruguière, Emilie Bogart, Marie-Cécile Le Deley, Eric Lartigau, Delphine Marre, David Pasquier
BACKGROUND/PURPOSE: Dose-escalated external beam radiotherapy (RT) is effective in the control of prostate cancer but is associated with a greater incidence of rectal adverse events. We assessed the dosimetric gain and safety profile associated with implantation of a new biodegradable rectal spacer balloon. MATERIALS/METHODS: Patients scheduled for image-guided, intensity-modulated RT for intermediate-risk prostate cancer were prospectively included in the French multicenter BioPro-RCMI-1505 study (NCT02478112)...
2021: Frontiers in Oncology
#25
REVIEW
T Le Roy, D Baron, B Vandendorpe, B Bataille, J M Hannoun-Levi, P Blanchard, E Lartigau, I Latorzeff, D Pasquier
Oligometastatic prostate cancer is among the most studied oligometastatic cancers in the literature. However few prospective studies have assessed stereotactic body radiotherapy (SBRT) for prostate cancer oligometastases. Two randomised phase II trials show a progression-free survival benefit compared with observation. Prospective registry data show very good local control and low toxicity too. Inclusion in ongoing trials should be strongly encouraged to define the role of SBRT in addition to systemic therapy...
October 2021: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
#26
JOURNAL ARTICLE
Alexandre Taillez, Andre-Michel Bimbai, Thomas Lacornerie, Marie-Cecile Le Deley, Eric F Lartigau, David Pasquier
Background: Understanding intra-fractional prostate motions is crucial for stereotactic body radiation therapy (SBRT). No studies have focused on the intra-fractional prostate motions during re-irradiation with SBRT. The objective was to evaluate these translational and rotational motions in primary treated patients and in the context of re-irradiation. Methods: From January 2011 to March 2020, 162 patients with histologically proven prostate cancer underwent prostate SBRT, including 58 as part of a re-irradiation treatment...
2021: Frontiers in Oncology
#27
JOURNAL ARTICLE
J Y Blay, S Boucher, B Le Vu, C Cropet, S Chabaud, D Perol, E Barranger, M Campone, T Conroy, C Coutant, R De Crevoisier, A Debreuve-Theresette, J P Delord, P Fumoleau, J Gentil, F Gomez, O Guerin, A Jaffré, E Lartigau, C Lemoine, M A Mahe, F X Mahon, H Mathieu-Daude, Y Merrouche, F Penault-Llorca, X Pivot, J C Soria, G Thomas, P Vera, T Vermeulin, P Viens, M Ychou, S Beaupere
BACKGROUND: The impact of the first coronavirus disease 2019 (COVID-19) wave on cancer patient management was measured within the nationwide network of the Unicancer comprehensive cancer centers in France. PATIENTS AND METHODS: The number of patients diagnosed and treated within 17 of the 18 Unicancer centers was collected in 2020 and compared with that during the same periods between 2016 and 2019. Unicancer centers treat close to 20% of cancer patients in France yearly...
April 17, 2021: ESMO Open
#28
JOURNAL ARTICLE
Hind Zaine, Benjamin Vandendorpe, Benoit Bataille, Thomas Lacornerie, Jennifer Wallet, Xavier Mirabel, Eric Lartigau, David Pasquier
Introduction: Salvage radiotherapy is the only curative treatment for biochemical progression after radical prostatectomy. Macroscopic recurrence may be found in the prostatic bed. The purpose of our study is to evaluate the effectiveness of salvage radiotherapy of the prostate bed with a boost to the area of the macroscopic recurrence. Material and Methods: From January 2005 to January 2020, 89 patients with macroscopic recurrence in the prostatectomy bed were treated with salvage radiotherapy +/- hormone therapy...
2021: Frontiers in Oncology
#29
JOURNAL ARTICLE
Nicolas Kluger, Marie Andraud, Céline Lartigau-Roussin, Nathalie Sultan-Bichat
The Koebner phenomenon is associated with cutaneous lupus erythematosus (CLE). A 20-year-old woman with a 10-year history of systemic lupus, treated with hydroxychloroquine and methotrexate, presented with features of chronic discoid lupus erythematosus (DLE) on the scalp, at the site of ear piercings, and on the temporal bone at the site of trauma from her jewelry. She also had subacute CLE (SCLE) lesions on old black tattoos. Histology and direct immunofluorescence confirmed CLE. We reviewed 13 cases of Koebner phenomenon on tattoos in patients with CLE (seven men, median age: 31...
March 2021: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
#30
JOURNAL ARTICLE
Alexandre Holmes, Elise Deniau, Christine Lartigau-Dagron, Antoine Bousquet, Sylvain Chambon, Natalie P Holmes
Development of carbon neutral and sustainable energy sources should be considered as a top priority solution for the growing worldwide energy demand. Photovoltaics are a strong candidate, more specifically, organic photovoltaics (OPV), enabling the design of flexible, lightweight, semitransparent, and low-cost solar cells. However, the active layer of OPV is, for now, mainly deposited from chlorinated solvents, harmful for the environment and for human health. Active layers processed from health and environmentally friendly solvents have over recent years formed a key focus topic of research, with the creation of aqueous dispersions of conjugated polymer nanoparticles arising...
February 23, 2021: ACS Nano
#31
JOURNAL ARTICLE
Nicolas Penel, Ali Hammoudi, Guillaume Marliot, Antoine De Courreges, Malgorzata Cucchi, Xavier Mirabel, Eric Leblanc, Eric Lartigau
The SARS-CoV-2 pandemic has significantly impacted cancer patient management. National and local recommendations to reduce SARS-CoV-2 transmission have been applied in a comprehensive cancer center located in Northern France. We prospectively measured key indicators for three successive eight-week periods: directly before, during, and right after the containment (from 16 March to 10 May 2020). Overall, the number of newly diagnosed and referred cancer patients in our hospital steadily increased (1027; 1135 and then 1704; +11% during containment and +50% just after)...
February 17, 2021: Medical Oncology
#32
JOURNAL ARTICLE
David Pasquier, Benoit Bataille, Florence Le Tinier, Raoudha Bennadji, Hélène Langin, Alexandre Escande, Emmanuelle Tresch, Franck Darloy, Damien Carlier, Frederik Crop, Eric Lartigau
ORCID: 0000-0001-6019-7309. In the treatment of breast cancer, intensity-modulated radiation therapy (IMRT) reportedly reduces the high-dose irradiation of at-risk organs and decreases the frequency of adverse events (AEs). Comparisons with conventional radiotherapy have shown that IMRT is associated with lower frequencies of acute and late-onset AEs. Here, we extended a prospective, observational, single-center study of the safety of IMRT to a second investigating center. Patients scheduled for adjuvant IMRT after partial or total mastectomy were given a dose of 50 Gy (25 fractions of 2 Gy over 5 weeks), with a simultaneous integrated boost in patients having undergone conservative surgery...
February 11, 2021: Scientific Reports
#33
JOURNAL ARTICLE
I Latorzeff, E Bogart, D Marre, M C Le Deley, É Lartigau, D Pasquier
No abstract text is available yet for this article.
October 2020: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
#34
JOURNAL ARTICLE
Benoît Bataille, Bennadji Raoudha, Florence Le Tinier, Laurent Basson, Alexandre Escande, Hélène Langin, Emmanuelle Tresch, Frederik Crop, Franck Darloy, Damien Carlier, Eric Lartigau, David Pasquier
The objective of this study was to evaluate the acute and medium-term toxicities, the quality of life, and aesthetic results of patients with breast cancer (BC) treated with tomotherapy. This was a prospective study, including patients with BC treated by tomotherapy. Radiation therapy delivered 50 Gy in 25 fractions to the breast or chest wall and to lymph node areas, with a simultaneous integrated boost at a dose of 60 Gy at the tumor bed in cases of breast conservative surgery. We included 288 patients, 168 and 120 treated with breast-conserving surgery and mastectomy respectively...
December 20, 2020: Cancers
#35
EDITORIAL
Marianne C Aznar, Carol Bacchus, Rob P Coppes, Eric Deutsch, Dietmar Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F Lartigau, Steffen Löck, Birgitte Offersen, Jens Overgaard, David I Thwaites, Albert J van der Kogel, Uulke A van der Heide, Vincenzo Valentini, Michael Baumann
No abstract text is available yet for this article.
December 30, 2020: Radiotherapy and Oncology
#36
JOURNAL ARTICLE
Rhode Ghislaine Nguewo Ngassam, Linnea Ung, Roxana Ologeanu-Taddei, Pascal Demoly, Jorick Lartigau, Anca M Chiriac
This paper presents the design and the users' perceptions of a Digital Allergy Card for recording, sharing and tracing information on drug allergies.
November 23, 2020: Studies in Health Technology and Informatics
#37
JOURNAL ARTICLE
Elina Zuelgaray, Sylvie Chevret, Marie Jachiet, Patrice Cacoub, Jean-Emmanuel Kahn, Matthieu Groh, Brigitte Granel, Manon Scafi, Loïk Geffray, François Chasset, Marc Gatfosse, Arsène Mekinian, Bertrand Lioger, Alfred Mahr, Francis Gaches, Martin Michaud, Isabelle Ludot, Florence Cordoliani, Adèle de Masson, Charles Cassius, Frédérique Retornaz, Alexandra Audemard-Verger, Céline Lartigau-Roussin, Mélanie Roriz, Benjamin Chaigne, Valérie Pallure, Isabelle Marie, Brice Castel, Valentine Loustau, Laurent Chiche, Pierre-Edouard Gavand, Pascal Cathebras, Stéphane Barete, Camille Frances, Emilie Brenaut, Yves Allenbach, Olivier Benveniste, Nicolas Noel, Geoffrey Urbanski, Olivier Hinschberger, Didier Bessis, Martine Bagot, Jean-David Bouaziz, Damien Sène
No abstract text is available yet for this article.
November 11, 2020: Journal of the American Academy of Dermatology
#38
JOURNAL ARTICLE
Vincent Ghysel, Emmanuelle Tresch, Guillaume Marliot, Romain Nicot, Marc Lambert, Guillaume Carbonnelle, Eric Lartigau, Gautier Lefebvre
INTRODUCTION: Cancer patients are particularly at risk for drug interactions. However, in oncology, this risk has not been studied in depth in France. The main objective of this study was to describe the proportion of drug interactions in patients with lung or digestive cancer. METHODS: The drug prescriptions of 93 patients were analyzed from may 27th, 2019 to July 07th, 2019 using two software programs (Thériaque™ and DDI Predictor™) in oncology patients hospitalized in our comprehensive cancer center...
October 1, 2020: Bulletin du Cancer
#39
JOURNAL ARTICLE
Marie Dworczak, Marie-Cécile Le Deley, Antoine Adenis, Guillaume Piessen, Éric Lartigau, Xavier Mirabel, Thomas Lacornerie, David Pasquier
INTRODUCTION: Preoperative chemoradiotherapy is an option for locally advanced esophageal cancer. Radiation therapy may increase postoperative pulmonary complications. Usual lungs dose constraints in radiotherapy are old and used by extrapolation of lung cancer management. Our objective is to review the literature on correlations between postoperative lung toxicity and dosimetric factors. METHOD: This literature review identified and selected studies published between 1987 and 2019 using the PRISMA method...
September 22, 2020: Bulletin du Cancer
#40
JOURNAL ARTICLE
D Pasquier, R Mouttet Audouard, G Martinage, T Lacornerie, X Mirabel, E Lartigau
Metastases are the most common brain tumors. After surgery, stereotactic radiotherapy (SRT) of the resection cavity is the standard of care. Data from two randomized trials indicate that SRT to the surgical bed is an effective treatment in reducing local failure as compared with observation, while reducing the risk of cognitive deterioration and maintaining quality of life as compared with whole brain radiation therapy. Local control appears higher after hypofractionated SRT compared to single-fraction SRT...
October 2020: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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