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C Lartigau-Roussin, M H Paclet, H Audin, B Toussaint, T Henni, L Raffray
INTRODUCTION: Macro-AST is recognized as a classical aetiology of isolated and persistent increase of serum aspartate aminotransferase (AST) levels. Macro-AST are high molecular weight complexes associating AST and a macromolecule, often an immunoglobulin. Although those macroenzymes of unknown pathogenesis are usually non-pathogenic, association with several diseases, including autoimmune diseases and liver diseases has been described. CASE REPORT: We report here the case of a 45-year-old patient with previously normal liver enzymes in whom an AST elevation and an IgA monoclonal gammopathy were discovered concomitantly...
October 13, 2016: La Revue de Médecine Interne
L Raffray, F Renou, M Bourdier-de-Beauregard, C Lartigau-Roussin, S Mohamed
No abstract text is available yet for this article.
October 13, 2016: La Revue de Médecine Interne
Frederik Crop, David Pasquier, Amandine Baczkiewic, Julie Doré, Lena Bequet, Emeline Steux, Anne Gadroy, Jacqueline Bouillon, Clement Florence, Laurence Muszynski, Mathilde Lacour, Eric Lartigau
A surface imaging system, Catalyst (C-Rad), was compared with laser-based positioning and daily mega voltage computed tomography (MVCT) setup for breast patients with nodal involvement treated by helical TomoTherapy. Catalyst-based positioning performed better than laser-based positioning. The respective modalities resulted in a standard deviation (SD), 68% confidence interval (CI) of positioning of left-right, craniocaudal, anterior-posterior, roll: 2.4 mm, 2.7 mm, 2.4 mm, 0.9° for Catalyst positioning, and 6...
2016: Journal of Applied Clinical Medical Physics
Abel Cordoba, Alexandre Escande, Stephanie Lopez, Laurent Mortier, Xavier Mirabel, Bernard Coche-Déqueant, Eric Lartigau
No abstract text is available yet for this article.
September 28, 2016: Radiation Oncology
I Karam, M Yao, D E Heron, I Poon, S Koyfman, S S Yom, F Siddiqui, E Lartigau, M Cengiz, H Yamazaki, W Hara, J Phan, J Vargo, V H Lee, R L Foote, K W W Harter, N Lee, A Sahgal, S S Lo
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
I Karam, M Yao, D E Heron, I Poon, S Koyfman, S S Yom, F Siddiqui, E Lartigau, M Cengiz, H Yamazaki, W Hara, J Phan, J Vargo, V H Lee, R L Foote, K W W Harter, N Lee, A Sahgal, S S Lo
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
A Cordoba, A Escande, T Leroy, X Mirabel, B Coche-Dequéant, E Lartigau
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
N Reynaert, B Demol, M Charoy, S Bouchoucha, F Crop, A Wagner, T Lacornerie, F Dubus, E Rault, P Comte, R Cayez, C Boydev, D Pasquier, X Mirabel, E Lartigau, T Sarrazin
PURPOSE: The main focus of the current paper is the clinical implementation of a Monte Carlo based platform for treatment plan validation for Tomotherapy and Cyberknife, without adding additional tasks to the dosimetry department. METHODS: The Monte Carlo platform consists of C++ classes for the actual functionality and a web based GUI that allows accessing the system using a web browser. Calculations are based on BEAMnrc/DOSXYZnrc and/or GATE and are performed automatically after exporting the dicom data from the treatment planning system...
September 19, 2016: Physica Medica: PM
D Pasquier, G Martinage, X Mirabel, T Lacornerie, S Makhloufi, J-C Faivre, S Thureau, É Lartigau
After the liver and lungs, bones are the third most common sites of cancer metastasis. Palliative radiotherapy for secondary bone tumours helps relieve pain, improve the quality of life and reduce the risk of fractures. Stereotactic body radiotherapy can deliver high radiation doses with very tight margins, which has significant advantages when treating tumours close to the spinal cord. Strict quality control is essential as dose gradient at the edge of the spinal cord is important. Optimal schedule is not defined...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Abel Cordoba, Alexandre Escande, Thomas Leroy, Xavier Mirabel, Bernard Coche-Dequéant, Eric Lartigau
PURPOSE: Evaluate the efficacy and tolerance of interstitial brachytherapy (IBT) after external beam radiotherapy (EBRT) or radio chemotherapy (RCT) for the treatment of anal canal cancers (ACC). METHODS AND MATERIALS: From 01, 1990 to 01, 2013, 103 patients (p) with ACC were treated with IBT after EBRT or RCT at our institution. Tumor node metastasis stage included Tis (1 p), T1 (18 p), T2 (46 p), T3 (33 p), and T4 (5 p). There was a lymph node involvement in 19 p...
September 2, 2016: Brachytherapy
A Cordoba, A Escande, S Lopez, L Mortier, X Mirabel, B Coche-Déqueant, E Lartigau
PURPOSE/OBJECTIVES: The aim of this study is to analyze the results of exclusive interstitial brachytherapy (IBT) as a conservative approach in the treatment of penile cancer confined to the glans or the shaft with long-term follow-up in a single institution. MATERIALS/METHODS: Between July 1992 and November 2013, 73 consecutive patients with non-metastatic invasive penile cancer were treated by Low dose rate (LDR) IBT in our institution. The localization of the primary lesion was glands in 67 patients (91...
2016: Radiation Oncology
Arthur Bertrand, Antoine Bousquet, Christine Lartigau-Dagron, Laurent Billon
Polymer films with hierarchical micro- and nano-porosities were prepared by combining the fast solvent evaporation "Breath Figure" (BF) method, exhibiting a highly regular honeycomb micro-porous texture, with the additional nanoscale self-assembly of polylactide-block-polystyrene (PLA-b-PS) diblock copolymers, PLA being used thereafter as a sacrificial component for nano-porosity.
July 21, 2016: Chemical Communications: Chem Comm
Maria Jesus Lobón, Francisco Bautista, François Riet, Frederic Dhermain, Sandra Canale, Christelle Dufour, Thomas Blauwblomme, Michel Zerah, Kevin Beccaria, Christian Saint-Rose, Stephanie Puget, Christian Carrie, Eric Lartigau, Pierre-Yves Bondiau, Dominique Valteau-Couanet, Jacques Grill, Stephanie Bolle
BACKGROUND: Standard treatment for recurrent ependymomas is not defined. Re- irradiation has been proposed but its modalities and results are still to be explored. PATIENTS AND METHODS: From June 1994 to December 2013, 32 pediatric patients with ependymoma were re-irradiated for local (n = 15) or metastatic (n = 17) relapses. Files were reviewed retrospectively. RESULTS: Local relapses were treated with hypofractionated focal radiotherapy (hypoFFRT) (n = 8) or focal fractionated radiotherapy (FFRT) (n = 7)...
2016: SpringerPlus
L Perrier, M Morelle, P Pommier, P Boisselier, E Lartigau, O Gallocher, M Alfonsi, E Bardet, M Rives, V Calugaru, E Chajon, G Noel, H Mecellem, D Pérol, S Dussart, P Giraud
No abstract text is available yet for this article.
November 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Oliver Blanck, Lei Wang, Wolfgang Baus, Jimm Grimm, Thomas Lacornerie, Joakim Nilsson, Sergii Luchkovskyi, Isabel Palazon Cano, Zhenyu Shou, Myriam Ayadi, Harald Treuer, Romain Viard, Frank-Andre Siebert, Mark K H Chan, Guido Hildebrandt, Jürgen Dunst, Detlef Imhoff, Stefan Wurster, Robert Wolff, Pantaleo Romanelli, Eric Lartigau, Robert Semrau, Scott G Soltys, Achim Schweikard
Stereotactic radiosurgery (SRS) is the accurate, conformal delivery of high-dose radiation to well-defined targets while minimizing normal structure doses via steep dose gradients. While inverse treatment planning (ITP) with computerized optimization algorithms are routine, many aspects of the planning process remain user-dependent. We performed an international, multi-institutional benchmark trial to study planning variability and to analyze preferable ITP practice for spinal robotic radiosurgery. 10 SRS treatment plans were generated for a complex-shaped spinal metastasis with 21 Gy in 3 fractions and tight constraints for spinal cord (V14Gy < 2 cc, V18Gy < 0...
2016: Journal of Applied Clinical Medical Physics
M Viau, A-F Perez, L Bodgi, C Devic, A Granzotto, M L Ferlazzo, M Bourguignon, A Puisieux, T Lacornerie, É Lartigau, J-L Lagrange, N Foray
The dose fractionation effect is a recurrent question of radiation biology research that remains unsolved since no model predicts the clinical effect only with the cumulated dose and the radiobiology of irradiated tissues. Such an important question is differentially answered in radioprotection, radiotherapy, radiology or epidemiology. A better understanding of the molecular response to radiation makes possible today a novel approach to identify the parameters that condition the fractionation effect. Particularly, the time between doses appears to be a key factor since it will permit, or not, the repair of certain radiation-induced DNA damages whose repair rates are of the order of seconds, minutes or hours: the fractionation effect will therefore vary according to the functionality of the different repair pathways, whatever for tumor or normal tissues...
May 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
David Pasquier, Laurence Boutaud de la Combe-Chossiere, Damien Carlier, Franck Darloy, Anne Catherine Degrendel-Courtecuisse, Chantal Dufour, Mustapha Fares, Laurent Gilbeau, Xavier Liem, Philippe Martin, Pascal Meyer, Jean François Minne, Olimpia Olszyk, Hassan Rhliouch, Marc Tokarski, Chloé Viot, Bernard Castelain, Eric Lartigau
BACKGROUND: Inter-observer delineation variation has been detailed for many years in almost every tumor location. Inadequate delineation can impair the chance of cure and/or increase toxicity. The aim of our original work was to prospectively improve the homogeneity of delineation among all of the senior radiation oncologists in the Nord-Pas de Calais region, irrespective of the conditions of practice. METHODS: All 11 centers were involved. The first studied cancer was prostate cancer...
2016: PloS One
Erwann Rault, Thomas Lacornerie, Hong-Phuong Dang, Frederik Crop, Eric Lartigau, Nick Reynaert, David Pasquier
BACKGROUND: Accelerated partial breast irradiation (APBI) is a new breast treatment modality aiming to reduce treatment time using hypo fractionation. Compared to conventional whole breast irradiation that takes 5 to 6 weeks, APBI is reported to induce worse cosmetic outcomes both when using three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT). These late normal tissue effects may be attributed to the dose volume effect because a large portion of the non-target breast tissue volume (NTBTV) receives a high dose...
2016: Radiation Oncology
Adeline Granzotto, Mohamed Amine Benadjaoud, Guillaume Vogin, Clément Devic, Mélanie L Ferlazzo, Larry Bodgi, Sandrine Pereira, Laurène Sonzogni, Fabien Forcheron, Muriel Viau, Aurélie Etaix, Karim Malek, Laurence Mengue-Bindjeme, Clémence Escoffier, Isabelle Rouvet, Marie-Thérèse Zabot, Aurélie Joubert, Anne Vincent, Nicole Dalla Venezia, Michel Bourguignon, Edme-Philippe Canat, Anne d'Hombres, Estelle Thébaud, Daniel Orbach, Dominique Stoppa-Lyonnet, Abderraouf Radji, Eric Doré, Yoann Pointreau, Céline Bourgier, Pierre Leblond, Anne-Sophie Defachelles, Cyril Lervat, Stéphanie Guey, Loic Feuvret, Françoise Gilsoul, Claire Berger, Coralie Moncharmont, Guy de Laroche, Marie-Virginie Moreau-Claeys, Nicole Chavaudra, Patrick Combemale, Marie-Claude Biston, Claude Malet, Isabelle Martel-Lafay, Cécile Laude, Ngoc-Hanh Hau-Desbat, Amira Ziouéche, Ronan Tanguy, Marie-Pierre Sunyach, Séverine Racadot, Pascal Pommier, Line Claude, Frédéric Baleydier, Bertrand Fleury, Renaud de Crevoisier, Jean-Marc Simon, Pierre Verrelle, Didier Peiffert, Yazid Belkacemi, Jean Bourhis, Eric Lartigau, Christian Carrie, Florent De Vathaire, François Eschwege, Alain Puisieux, Jean-Léon Lagrange, Jacques Balosso, Nicolas Foray
PURPOSE: Whereas post-radiation therapy overreactions (OR) represent a clinical and societal issue, there is still no consensual radiobiological endpoint to predict clinical radiosensitivity. Since 2003, skin biopsy specimens have been collected from patients treated by radiation therapy against different tumor localizations and showing a wide range of OR. Here, we aimed to establish quantitative links between radiobiological factors and OR severity grades that would be relevant to radioresistant and genetic hyperradiosensitive cases...
March 1, 2016: International Journal of Radiation Oncology, Biology, Physics
David Azria, Olivier Riou, Florence Castan, Tan Dat Nguyen, Karine Peignaux, Claire Lemanski, Jean-Léon Lagrange, Youlia Kirova, Eric Lartigau, Yazid Belkacemi, Céline Bourgier, Sofia Rivera, Georges Noël, Sébastien Clippe, Françoise Mornex, Christophe Hennequin, Andrew Kramar, Sophie Gourgou, André Pèlegrin, Pascal Fenoglietto, Esat Mahmut Ozsahin
BACKGROUND: Monocentric cohorts suggested that radiation-induced CD8 T-lymphocyte apoptosis (RILA) can predict late toxicity after curative intent radiotherapy (RT). We assessed the role of RILA as a predictor of breast fibrosis (bf +) after adjuvant breast RT in a prospective multicenter trial. METHODS: A total of 502 breast-cancer patients (pts) treated by conservative surgery and adjuvant RT were recruited at ten centers. RILA was assessed before RT by flow cytometry...
December 2015: EBioMedicine
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