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Fatty liver of pregnancy

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https://www.readbyqxmd.com/read/29785905/hepatic-sirt3-expression-declines-postpartum-in-dairy-goats
#1
Lei Liu, Li Yao, Tao Peng, Lixin Wen, Wenjie Cai, Xinglin Jia, Jianhua He
The experiments reported in this research communication aimed to plot the expression pattern of Sirt3, a master regulator of energy metabolism and antioxidation defence, in the liver of dairy goats during perinatal period. Ten healthy dairy goats in late pregnancy were chosen, and needle biopsy was applied to collect liver samples at 1-week intervals. Protein levels of hepatic Sirt3 were analysed by western-blotting. Serum enzyme activities of manganese superoxide dismutase (Mn-SOD) and non-esterified fatty acids (NEFA) levels were measured, and their correlation with Sirt3 mRNA levels was also estimated...
May 2018: Journal of Dairy Research
https://www.readbyqxmd.com/read/29725629/acute-kidney-injury-in-pregnancy-the-changing-landscape-for-the-21st-century
#2
REVIEW
Swati Rao, Belinda Jim
Pregnancy-related acute kidney injury (Pr-AKI) remains a large public health problem, with decreasing incidences in developing countries but seemingly increasing incidences in the United States and Canada. These epidemiologic changes are reflective of the advances in medical and obstetric care, as well as changes in underlying maternal risk factors. The risk factors associated with advanced maternal age, such as hypertension, diabetes, chronic kidney disease, and those associated with reproductive technologies such as multiple gestations, are increasing...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29701266/sex-specific-alterations-in-serology-and-the-expression-of-liver-fatp4-protein-in-offspring-exposed-to-high-fat-diet-during-pregnancy-and-or-lactation
#3
Mingqiu Zhao, Yi Li, Huihui Yao, Lihua Dou, Shuya Zhang, Qihong Zhao, Li Li
Changes in dietary composition will have a significant impact on the nutritional status of the mother and the offspring. To examine the relevant hormone level changes during lactation and the expression of fatty acid transporters in the placenta and liver under the condition of a high-fat (HF) diet, we established HF animal models and conducted a cross-fostering program to mimic the shift in diet. On gestation day (GD)18, the weight of placenta in the HF group was significantly higher than that in the control group (p < 0...
March 2018: Lipids
https://www.readbyqxmd.com/read/29697671/-liver-disease-and-maternal-mortality
#4
A P Nadeev, V A Zhukova, M A Travin, S P Mozoleva
Liver diseases associated (acute fatty liver of pregnancy) and unassociated (liver hemangioma) with pregnancy and complications due to liver failure are serious conditions and can lead to maternal death. The paper describes two maternal deaths related to liver pathology.
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29697666/-the-clinical-and-anatomical-aspects-of-preeclampsia-current-features-of-its-course
#5
L M Mikhaleva, N A Gracheva, A E Biryukov
Preeclampsia is the most menacing complication of pregnancy and childbirth worldwide and remains one of the leading causes of maternal and perinatal morbidity and mortality. It is characterized by a complex etiopathogenesis with specific clinical and laboratory changes (hypertension, proteinuria and edema), as well as by the morphological pattern of target organ damage and uteroplacental blood vascular lesions. However, the triad of clinical signs of preeclampsia is not encountered in all cases now. OBJECTIVE: to study the clinical and anatomical aspects of preeclampsia at the present stage...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29682369/intrahepatic-cholangiocarcinoma-masquerading-as-acute-fatty-liver-of-pregnancy-a-case-report-and-review-of-the-literature
#6
Ayman Qasrawi, Omar Abughanimeh, Mouhanna Abu Ghanimeh, Simran Arora-Elder, Osama Yousef, Tarek Tamimi
Cholangiocarcinoma (CCA) is an uncommon cancer and accounts only for 3% of all gastrointestinal malignancies. In this report, we present a case of an intrahepatic cholangiocarcinoma masquerading as acute fatty liver of pregnancy (AFLP). A 38-year-old female who is 36-week pregnant presented with a 1-week history of headache, nausea, vomiting, and right upper abdominal pain, along with hepatomegaly. Laboratory investigations were remarkable for mild leukocytosis, hyperbilirubinemia, proteinuria, and elevated transaminases and prothrombin time...
2018: Case Reports in Hepatology
https://www.readbyqxmd.com/read/29680650/feeding-increasing-amounts-of-ruminally-protected-choline-decreased-fatty-liver-in-nonlactating-pregnant-holstein-cows-in-negative-energy-status
#7
M G Zenobi, T L Scheffler, J E Zuniga, M B Poindexter, S R Campagna, H F Castro Gonzalez, A T Farmer, B A Barton, J E P Santos, C R Staples
The objectives were to determine the optimal feeding amount of choline in a ruminally protected form to reduce the triacylglycerol (TAG) concentration in liver and to increase TAG in blood plasma of dairy cows. Pregnant, nonlactating multiparous Holstein cows (n = 77) were blocked by body condition score (3.59 ± 0.33) and assigned to treatment at 64 ± 10 d before calculated calving date. Dietary treatments were top-dressing of 0, 30, 60, 90, or 120 g/d of ruminally protected choline (RPC; Balchem Corp., New Hampton, NY) ions to supply the equivalent of 0, 6...
April 18, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29644153/acute-fatty-liver-of-pregnancy-a-thorough-examination-of-a-harmful-obstetrical-syndrome-and-its-counterparts
#8
Joshua Ronen, Shahzeb Shaheen, David Steinberg, Kevin R Justus
Diagnosed in one of every 20,000 deliveries, acute fatty liver of pregnancy (AFLP) was considered to be a deadly disease for many years. However, advancements in the clinical and surgical management of pregnant mothers have lead to a drastic decrease in maternal morbidity and mortality. The corresponding case recounts a 23-year-old gravida 2 para 1 (G2P1) at 38 weeks gestational age (GA) with no relevant past medical or family medical history that presented to the emergency department (ED) with a five-day history of nausea, protracted vomiting, hypertension, and new-onset headache...
February 6, 2018: Curēus
https://www.readbyqxmd.com/read/29609233/-regulation-of-pravastatin-on-long-chain-fatty-acid-oxidative-enzyme-in-pre-eclampsia-like-mouse-model
#9
J Huai, Z Yang, Y H Yi, G J Wang, Q Q Xiang
Objective: To investigate the modulation of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) expression by pravastatin in pre-eclampsia-like mouse model. Methods: C57BL/6J mice were randomly injected with N-nitro-L-arginine methyl ester (L-NAME) as pre-eclampsia-like model group (PE) or saline as normal pregnancy control group (Con) respectively, from gestational the 7th to 18th day. For each group, pravastatin (PE+Pra, Con+Pra group) or saline (PE+N, Con+N Group) was given from the 8th to 18th day of gestation, respectively...
March 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29577863/hepatic-elimination-of-drugs-in-gestational-diabetes
#10
Claudio Daniel Gonzalez, Jorge Alvarinas, Ricardo Bolanos, Guillermo Di Girolamo
BACKGROUND: The liver is the major metabolic clearance organ for chemical agents from the human body. Pregnancy is associated with several physiological changes that may affect one or more of these factors, and also induces changes in the hepatic clearance of certain drugs.The aim of this paper was to review some of the currently available information in the field to provide some insights about the relevance of these changes on the clearance of some drugs. METHODS: A comprehensive literature search was carried out to identify eligible studies from MEDLINE/PubMed, EMBASE and SCIELO databases through 1970 first semester...
March 25, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29561026/the-protective-effect-of-polyunsaturated-fatty-acid-intake-during-pregnancy-against-embryotoxicity-of-sodium-valproate-in-mice
#11
Kelei Li, Jiaomei Li, Jiaojiao Gu, Xiaofei Guo, Tianlin Gao, Duo Li
Sodium valproate (VPA) is an anti-epileptic drug, but has a strong embryotoxicity due to its induced disturbance of folate-homocysteine (Hcy) metabolism and fatty acid metabolism. The aim of the present study was to investigate whether polyunsaturated fatty acid (PUFA) intake during pregnancy can relieve the embryotoxicity of VPA. VPA (dose: 500 mg kg-1, concentration: 38.5 mg ml-1) was intraperitoneally injected into pregnant mice on day 8.5 of gestation (E8.5d). PUFA intake significantly decreased fetal mortality and NTD incidence induced by VPA: n-3 long chain PUFAs (n-3 LCPUFAs) in fish oil had the best decreasing effect, followed by C18:3n-3 in flaxseed oil and then C18:2n-6 in corn oil...
May 23, 2018: Food & Function
https://www.readbyqxmd.com/read/29560268/maternal-undernutrition-and-offspring-sex-determine-birth-weight-postnatal-development-and-meat-characteristics-in-traditional-swine-breeds
#12
M Vázquez-Gómez, C García-Contreras, L Torres-Rovira, S Astiz, C Óvilo, A González-Bulnes, B Isabel
Background: The aim of this study was to determine how maternal undernutrition during pregnancy and offspring birth-weight can affect the postnatal development of offspring under farm conditions, which may lead to consequences in its meat and carcass quality. The current study involved a total of 80 litters from Iberian sows fed a diet fulfilling daily requirements ( n  = 47; control) or providing 70% daily requirements ( n  = 33; underfed) from d 38 to d 90 of gestation when fetal tissue development begins...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29493093/highlights-of-the-2017-european-aids-clinical-society-eacs-guidelines-for-the-treatment-of-adult-hiv-positive-persons-version-9-0
#13
L Ryom, C Boesecke, M Bracchi, J Ambrosioni, A Pozniak, J Arribas, G Behrens, Pgm Mallon, M Puoti, A Rauch, J M Miro, O Kirk, C Marzolini, J D Lundgren, M Battegay
BACKGROUND: The European AIDS Clinical Society (EACS) Guidelines have since 2005 provided multidisciplinary recommendations for the care of HIV-positive persons in geographically diverse areas. GUIDELINE HIGHLIGHTS: Major revisions have been made in all sections of the 2017 Guidelines: antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Newly added are also a summary of the main changes made, and direct video links to the EACS online course on HIV Management...
May 2018: HIV Medicine
https://www.readbyqxmd.com/read/29467534/the-hibernating-bear-a-good-analogy-to-explain-why-acute-fatty-liver-of-pregnancy-manifests-in-late-pregnancy
#14
Uday Zachariah, Ashish Goel, K A Balasubramanian, C E Eapen
No abstract text is available yet for this article.
February 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29467407/maternal-obesity-induced-decreases-in-plasma-hepatic-and-uterine-polyunsaturated-fatty-acids-during-labour-is-reversed-through-improved-nutrition-at-conception
#15
Ronan Muir, Ge Liu, Raheela Khan, Anatoly Shmygol, Siobhan Quenby, Robert Alan Gibson, Beverly Muhlhausler, Matthew Elmes
Maternal obesity is associated with prolonged and dysfunctional labour, potentially through decreased synthesis of prostaglandins that stimulate myometrial contractions. We assessed the impact of maternal obesity on concentrations of precursor fatty acids (FA) for prostaglandin synthesis and whether any changes could be reversed by improved nutrition post-conception. Wistar rats were fed control (CON) or High-Fat, High-cholesterol (HFHC) diets 6 weeks before mating. At conception half the dams switched diets providing 4 dietary groups: (1) CON, (2) HFHC, (3) CON-HFHC or (4) HFHC-CON...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29451152/different-effects-of-pravastatin-on-preeclampsia-like-symptoms-in-different-mouse-models
#16
Jing Huai, Zi Yang, Yan-Hong Yi, Guang-Jiao Wang
Background: Pravastatin (Pra) exerts protective effects on preeclampsia. Preeclampsia is a multifactorial and pathogenic pathway syndrome. The present study compared the effects of Pra on clinical manifestations of preeclampsia in different pathogenic pathways. Methods: Two different preeclampsia-like mouse models used in this study were generated with Nω-nitro-L-arginine methyl ester (L-NAME) and used lipopolysaccharide (LPS) from day 7 of gestation, respectively...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29403301/early-exposure-to-distinct-sources-of-lipids-affects-differently-the-development-and-hepatic-inflammatory-profiles-of-21-day-old-rat-offspring
#17
Laís Vales Mennitti, Lila Missae Oyama, Aline Boveto Santamarina, Claudia Maria da Penha Oller do Nascimento, Luciana Pellegrini Pisani
Introduction: Maternal diet composition of fatty acids during pregnancy and lactation seems to modify the fetal programming, epigenetic pattern and offspring phenotype. Aim: Herein, we investigated the effects of maternal consumption of normal-fat diets with distinct lipid sources during pregnancy and lactation on the somatic development and proinflammatory status of 21-day-old rat offspring. Materials and Methods: On the first day of pregnancy, female Wistar rats were divided into four groups as follows: soybean oil (M-SO), lard (M-L), hydrogenated vegetable fat (M-HVF) and fish oil (M-FO)...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29375874/acute-fatty-liver-of-pregnancy-simulating-liver-tumor
#18
Benjamin Anon, Béatrice Scotto, Yannick Bacq
Acute fatty liver of pregnancy (AFLP) is a rare liver disease unique to pregnancy that can lead to acute liver failure. Clinicians must have a high index of suspicion for AFLP because only early diagnosis and prompt delivery improve maternal and fetal prognosis.
January 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29361796/role-of-3-hydroxy-fatty-acid-induced-hepatic-lipotoxicity-in-acute-fatty-liver-of-pregnancy
#19
REVIEW
Sathish Kumar Natarajan, Jamal A Ibdah
Acute fatty liver of pregnancy (AFLP), a catastrophic illness for both the mother and the unborn offspring, develops in the last trimester of pregnancy with significant maternal and perinatal mortality. AFLP is also recognized as an obstetric and medical emergency. Maternal AFLP is highly associated with a fetal homozygous mutation (1528G>C) in the gene that encodes for mitochondrial long-chain hydroxy acyl-CoA dehydrogenase (LCHAD). The mutation in LCHAD results in the accumulation of 3-hydroxy fatty acids, such as 3-hydroxy myristic acid, 3-hydroxy palmitic acid and 3-hydroxy dicarboxylic acid in the placenta, which are then shunted to the maternal circulation leading to the development of acute liver injury observed in patients with AFLP...
January 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29325296/-clinical-features-and-treatment-of-acute-fatty-liver-of-pregnancy-complicated-by-acute-liver-failure
#20
H F Xiong, J Y Liu, L M Guo, C S Li, J B Tan, Y F Liu, Y Sun, L Pu, P Xiang, M Zhang
No abstract text is available yet for this article.
December 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
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