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quorum sensing and resistence gene

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https://www.readbyqxmd.com/read/29445868/induction-of-systemic-resistance-in-tomato-against-botrytis-cinerea-by-n-decanoyl-homoserine-lactone-via-jasmonic-acid-signaling
#1
Zhangjian Hu, Shujun Shao, Chenfei Zheng, Zenghui Sun, Junying Shi, Jingquan Yu, Zhenyu Qi, Kai Shi
N-decanoyl-homoserine lactone activates plant systemic resistance against Botrytis cinerea in tomato plants, which is largely dependent on jasmonic acid biosynthesis and signal transduction pathways. Rhizosphere bacteria secrete N-acylated-homoserine lactones (AHLs), a type of specialized quorum-sensing signal molecule, to coordinate their population density during communication with their eukaryotic hosts. AHLs behave as low molecular weight ligands that are sensed by plants and promote the host's resistance against foliar pathogens...
February 14, 2018: Planta
https://www.readbyqxmd.com/read/29431875/phytosynthesized-silver-nanoparticles-as-anti-quorum-sensing-and-antibiofilm-agent-against-the-nosocomial-pathogen-serratia-marcescens-an-in-vitro-study
#2
Durgadevi Ravindran, Srinivasan Ramanathan, Kannappan Arunachalam, Godfred Ponraj Jeyaraj, Karutha Pandian Shunmugiah, Veera Ravi Arumugam
AIM: Serratia marcescens is an important multidrug-resistant human pathogen. The pathogenicity of S. marcescens mainly depends on the Quorum Sensing (QS) mechanism, which regulates the virulence factors production and biofilm formation. Hence, targeting QS mechanism in S. marcescens will ultimately pave the way to combat its pathogenicity. Thus, the present study is intended to evaluate the efficacy of Vetiveria zizanioides root extract mediated silver nanoparticles (AgNPs) as a potent anti-QS and antibiofilm agent against S...
February 12, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29412107/genetic-mechanisms-of-antibiotic-resistance-and-the-role-of-antibiotic-adjuvants
#3
Daniela Santos Pontes, Rodrigo Santos Aquino de Araujo, Natalina Dantas, Luciana Scotti, Marcus Tullius Scotti, Ricardo Olimpio de Moura, Francisco Jaime Bezerra Mendonca-Junior
The ever increasing number of multidrug-resistant microorganism pathogens has become a great and global public health threat. Antibiotic mechanisms of action and the opposing mechanisms of resistance are intimately associated, but comprehension of the biochemical and molecular functions of such drugs is not a simple exercise. Both the environment, and genetic settings contribute to alterations in phenotypic resistance (natural bacterial evolution), and make it difficult to control the emergence and impacts of antibiotic resistance...
February 5, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29382732/qstatin-a-selective-inhibitor-of-quorum-sensing-in-vibrio-species
#4
Byoung Sik Kim, Song Yee Jang, Ye-Ji Bang, Jungwon Hwang, Youngwon Koo, Kyung Ku Jang, Dongyeol Lim, Myung Hee Kim, Sang Ho Choi
Pathogenic Vibrio species cause diseases in diverse marine animals reared in aquaculture. Since their pathogenesis, persistence, and survival in marine environments are regulated by quorum sensing (QS), QS interference has attracted attention as a means to control these bacteria in aquatic settings. A few QS inhibitors of Vibrio species have been reported, but detailed molecular mechanisms are lacking. Here, we identified a novel, potent, and selective Vibrio QS inhibitor, named QStatin [1-(5-bromothiophene-2-sulfonyl)-1H-pyrazole], which affects Vibrio harveyi LuxR homologues, the well-conserved master transcriptional regulators for QS in Vibrio species...
January 30, 2018: MBio
https://www.readbyqxmd.com/read/29359191/targeting-virulence-in-staphylococcus-aureus-by-chemical-inhibition-of-the-accessory-gene-regulator-system-in-vivo
#5
REVIEW
Akram M Salam, Cassandra L Quave
Methicillin-resistant Staphylococcus aureus (MRSA) presents one of the most serious health concerns worldwide. The WHO labeled it as a "high-priority" pathogen in 2017, also citing the more recently emerged vancomycin-intermediate and -resistant strains. With the spread of antibiotic resistance due in large part to the selective pressure exerted by conventional antibiotics, the use of antivirulence strategies has been recurrently proposed as a promising therapeutic approach. In MRSA, virulence is chiefly controlled by quorum sensing (QS); inhibitors of QS are called quorum quenchers (QQ)...
January 2018: MSphere
https://www.readbyqxmd.com/read/29352085/the-expression-of-bacteriocin-production-and-self-resistance-in-lactobacillus-brevis-174a-is-mediated-by-two-regulatory-proteins
#6
Masafumi Noda, Rumi Miyauchi, Narandalai Danshiitsoodol, Yasuyuki Matoba, Takanori Kumagai, Masanori Sugiyama
We have previously shown that a lactic acid bacterium Lactobacillus (Lb.) brevis 174A isolated from a Citrus iyo fruit produces bacteriocin designated brevicin 174A, which is comprised of two antibacterial polypeptides (designated brevicin 174A-β and 174A-γ). We have also found a gene cluster, composed of eight open reading frames (ORFs), that contains genes for the biosynthesis of brevicin 174A, self-resistance to its own bacteriocin, and two transcriptional regulatory proteins.Some lactic acid bacterial strains have a system to start the production of bacteriocin at an adequate stage of the growth...
January 19, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29350317/a-study-on-the-role-that-quorum-sensing-play-in-antibiotic-resistant-plasmid-conjugative-transfer-in-escherichia-coli
#7
Yueheng Zhang, Qingping Ma, Bingmei Su, Rui Chen, Juan Lin, Zhifen Lin, Dali Wang, Yang Yu
Horizontal genes transfer (HGT) plays an important role in the dissemination of antibiotic resistance genes (ARGs) in the environment. However, the mechanisms of HGT of ARGs under the influence of antibiotics in sub-MIC remain rarely explored. Moreover, given its collective nature, HGT was considered to be relative to quorum sensing (QS) system. To investigate whether QS has any impact on horizontal gene transfer of ARGs, experiments were conducted to determine the conjugative efficiency of plasmid RP4 on Escherichia coli (E...
January 19, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29290510/effect-of-nano-silver-nano-copper-deconex-and-benzalkonium-chloride-on-biofilm-formation-and-expression-of-transcription-regulatory-quorum-sensing-gene-rh1r-in-drug-resistance-pseudomonas-aeruginosa-burn-isolates
#8
Melika Gholamrezazadeh, Mohammad Reza Shakibaie, Fatemeh Monirzadeh, Shalaleh Masoumi, Zahra Hashemizadeh
BACKGROUND: Biofilm forming drug-resistant Pseudomonas aeruginosa are responsible for major death in burn center of different hospitals across the globe. OBJECTIVE: The aims of this study were to evaluate the effect of nano-silver (Ag), nano-copper (Cu), and two hospital disinfectants (deconex and benzalkonium chloride) on biofilm formation and expression of transcription regulatory quorum sensing gene rh1R in P. aeruginosa burn isolates. METHODS: 28 multidrug-resistant P...
December 28, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29288300/biogenic-synthesis-of-silver-nanoparticles-using-piper-betle-aqueous-extract-and-evaluation-of-its-anti-quorum-sensing-and-antibiofilm-potential-against-uropathogens-with-cytotoxic-effects-an-in-vitro-and-in-vivo-approach
#9
Ramanathan Srinivasan, Loganathan Vigneshwari, Tamilselvam Rajavel, Ravindran Durgadevi, Arunachalam Kannappan, Krishnaswamy Balamurugan, Kasi Pandima Devi, Arumugam Veera Ravi
Urinary tract infections are the utmost common bacterial infections caused by Proteus mirabilis, Pseudomonas aeruginosa, Escherichia coli, and Serratia marcescens. These uropathogens resist the action of several antibiotics due to their ability to form biofilms. Most of these bacterial pathogens use the quorum sensing (QS) machinery to co-ordinate their cells and regulate several virulence factors and biofilm formation. On the other hand, the anti-quorum sensing (anti-QS) and antibiofilm potential of silver nanoparticles have been well reported against certain bacterial pathogens, but to the best of our knowledge, no report is available against the pathogenicity of uropathogens in particular S...
December 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29250041/stenotrophomonas-maltophilia-as-an-emerging-ubiquitous-pathogen-looking-beyond-contemporary-antibiotic-therapy
#10
REVIEW
Anthony A Adegoke, Thor A Stenström, Anthony I Okoh
Stenotrophomonas maltophilia is a commensal and an emerging pathogen earlier noted in broad-spectrum life threatening infections among the vulnerable, but more recently as a pathogen in immunocompetent individuals. The bacteria are consistently being implicated in necrotizing otitis, cutaneous infections including soft tissue infection and keratitis, endocarditis, meningitis, acute respiratory tract infection (RTI), bacteraemia (with/without hematological malignancies), tropical pyomyositis, cystic fibrosis, septic arthritis, among others...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29229911/comparative-genome-analysis-of-the-vineyard-weed-endophyte-pseudomonas-viridiflava-cdrtc14-showing-selective-herbicidal-activity
#11
Abdul Samad, Livio Antonielli, Angela Sessitsch, Stéphane Compant, Friederike Trognitz
Microbes produce a variety of secondary metabolites to be explored for herbicidal activities. We investigated an endophyte Pseudomonas viridiflava CDRTc14, which impacted growth of its host Lepidium draba L., to better understand the possible genetic determinants for herbicidal and host-interaction traits. Inoculation tests with a variety of target plants revealed that CDRTc14 shows plant-specific effects ranging from beneficial to negative. Its herbicidal effect appeared to be dose-dependent and resembled phenotypically the germination arrest factor of Pseudomonas fluorescens WH6...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29225430/insights-from-the-molecular-dynamics-simulation-of-bcsd-subunit-from-k-xylinus
#12
Simranjit Kaur, Mahesh Kulharia
Biofilms are bacteria living in micro-colonies with a protective coating in sessile form. The biofilm protects bacteria from harsh surroundings as well as help in antibiotics resistance using a semi-fluid substance. Cellulose is the major component of biofilm, which provides the sticky appearance to bacteria for attaching to the substratum. The bacteria communicate in biofilm with the help of quorum sensing hormones Acylated Homoserine Lactones (AHL's). In Komagataeibacter xylinus the four genes Bcs A, Bcs B, Bcs C, Bcs D are associated with cellulose biosynthesis...
2017: Bioinformation
https://www.readbyqxmd.com/read/29215165/transcriptional-response-of-nautella-italica-r11-towards-its-macroalgal-host-uncovers-new-mechanisms-of-host-pathogen-interaction
#13
Jennifer Hudson, Melissa Gardiner, Nandan Deshpande, Suhelen Egan
Macroalgae (seaweeds) are essential for the functioning of temperate marine ecosystems, but there is increasing evidence to suggest that their survival is under threat from anthropogenic stressors and disease. Nautella italica R11 is recognised as an etiological agent of bleaching disease in the red alga, Delisea pulchra. Yet, there is a lack of knowledge surrounding the molecular mechanisms involved in this model host-pathogen interaction. Here we report that mutations in the gene encoding for a LuxR-type quorum sensing transcriptional regulator, RaiR, render N...
December 7, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29203527/a-novel-chemical-inducer-of-streptococcus-quorum-sensing-acts-by-inhibiting-the-pheromone-degrading-endopeptidase-pepo
#14
Tiara G Pérez Morales, Kiira Ratia, Duo-Sheng Wang, Artemis Gogos, Tom G Driver, Michael J Federle
Bacteria produce chemical signals (pheromones) to coordinate behaviors across a population in a process termed quorum sensing (QS). QS systems comprising peptide pheromones and their corresponding Rgg receptors are widespread among Firmicutes and may be useful targets for manipulating microbial behaviors, like suppressing virulence. The Rgg2/3 QS circuit of the human pathogen Streptococcus pyogenes controls genes affecting resistance to host lysozyme in response to short hydrophobic pheromones (SHPs). Considering that artificial activation of a QS pathway may be as useful in the objective of manipulating bacteria as inhibiting it, we sought to identify small-molecule inducers of the Rgg2/3 QS system...
December 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29178590/meloxicam-inhibits-biofilm-formation-and-enhances-antimicrobial-agents-efficacy-by-pseudomonas-aeruginosa
#15
Pengfei She, Yangxia Wang, Zhen Luo, Lihua Chen, Ruichen Tan, Yanle Wang, Yong Wu
Microbial biofilms are communities of surface-adhered cells enclosed in a matrix of extracellular polymeric substances. Bacterial cells in biofilm are 10~1,000-fold more resistant to antimicrobials than the planktonic cells. Burgeoning antibiotic resistance in Pseudomonas aeruginosa biofilm has necessitated the development of antimicrobial agents. Here, we have investigated the antibiofilm effect of meloxicam against P. aeruginosaPAO1 and its potential mechanisms. Further, we have explored whether meloxicam could enhance the susceptibility of bacterial biofilms to treatment with conventional antimicrobials...
November 27, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29150517/multi-omics-reveal-the-lifestyle-of-the-acidophilic-mineral-oxidizing-model-species-leptospirillum-ferriphilum-t
#16
Stephan Christel, Malte Herold, Sören Bellenberg, Mohamed El Hajjami, Antoine Buetti-Dinh, Igor V Pivkin, Wolfgang Sand, Paul Wilmes, Ansgar Poetsch, Mark Dopson
Leptospirillum ferriphilum plays a major role in acidic, metal rich environments where it represents one of the most prevalent iron oxidizers. These milieus include acid rock and mine drainage as well as biomining operations. Despite its perceived importance, no complete genome sequence of this model species' type strain is available, limiting the possibilities to investigate the strategies and adaptations Leptospirillum ferriphilum(T) applies to survive and compete in its niche. This study presents a complete, circular genome of Leptospirillum ferriphilum(T) DSM 14647 obtained by PacBio SMRT long read sequencing for use as a high quality reference...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29130185/identification-of-ai-2-quorum-sensing-inhibitors-in-vibrio-harveyi-through-structure-based-virtual-screening
#17
Tianyu Jiang, Peng Zhu, Lupei Du, Minyong Li
Quorum sensing (QS) is a cell-to-cell communication system that regulates gene expression as a result of the production and perception of signal molecules called autoinducers (AIs). AI-2 is a QS autoinducer produced by both Gram-negative and Gram-positive bacteria, in which it regulates intraspecies and interspecies communication. The identification of QS inhibitors is considered a promising strategy for the development of anti-virulence drugs with reduced selective pressure for resistance. Here we describe a high-throughput virtual screening approach to identify AI-2 quorum sensing inhibitors on the basis of Vibrio harveyi LuxPQ crystal structure...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29130176/assessing-pseudomonas-aeruginosa-autoinducer-effects-on-mammalian-epithelial-cells
#18
Jake Everett, Rebecca Gabrilska, Kendra P Rumbaugh, Elena Vikström
The human mucosal environment in the gut is rich with interactions between microbiota and mammalian epithelia. Microbes such as the Gram-negative bacterium Pseudomonas aeruginosa may use quorum sensing to communicate with other microorganisms and mammalian cells to alter gene expression. Here, we present methodologies to evaluate the effects of P. aeruginosa N-(3-oxo-dodecanoyl)-L-homoserine lactone (3O-C12-HSL) on Caco-2 cell monolayers. First, we describe a method for assessing barrier function and permeability of epithelial cells when exposed to 3O-C12-HSL by measuring transepithelial electrical resistance (TER) and paracellular flow using fluorescently labeled dextran...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29099398/electric-field-based-dressing-disrupts-mixed-species-bacterial-biofilm-infection-and-restores-functional-wound-healing
#19
Kasturi Ganesh Barki, Amitava Das, Sriteja Dixith, Piya Das Ghatak, Shomita Mathew-Steiner, Elizabeth Schwab, Savita Khanna, Daniel J Wozniak, Sashwati Roy, Chandan K Sen
OBJECTIVE: This study was designed to employ electroceutical principles, as an alternative to pharmacological intervention, to manage wound biofilm infection. Mechanism of action of a United States Food and Drug Administration-cleared wireless electroceutical dressing (WED) was tested in an established porcine chronic wound polymicrobial biofilm infection model involving inoculation with Pseudomonas aeruginosa PAO1 and Acinetobacter baumannii 19606. BACKGROUND: Bacterial biofilms represent a major wound complication...
November 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29095142/high-mortality-of-bloodstream-infection-outbreak-caused-by-carbapenem-resistant-p-aeruginosa-producing-spm-1-in-a-bone-marrow-transplant-unit
#20
Lucas Chaves, Lísia Moura Tomich, Matias Salomão, Gleice Cristina Leite, Jessica Ramos, Roberta Ruedas Martins, Camila Rizek, Patricia Neves, Marjorie Vieira Batista, Ulysses Amigo, Thais Guimaraes, Anna Sara Levin, Silvia Figueiredo Costa
PURPOSE: Carbapenem resistance in P. aeruginosa is increasing worldwide. In Brazil, SPM-1 is the main P. aeruginosa carbapenemase identified. Little is known about the virulence factor in SPM-1 clones.Methodolgy. We describe a carbapenem-resistant P. aeruginosa bloodstream infection (CRPa-BSI) outbreak in a bone marrow transplant Unit (BMT). Twenty-nine CRPa-BSI cases were compared to 58 controls. Microbiological characteristics of isolates, such as sensitivity, carbapenemase gene PCR for P...
November 2, 2017: Journal of Medical Microbiology
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