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quorum sensing and resistence gene

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https://www.readbyqxmd.com/read/28650325/evaluation-of-three-plant-extracts-against-biofilm-formation-and-expression-of-quorum-sensing-regulated-virulence-factors-in-pseudomonas-aeruginosa
#1
Vajihe Karbasizade, Parichehr Dehghan, Maryam Mohammadi Sichani, Kahin Shahanipoor, Reyhaneh Jafari, Rozita Yousefian
Following the increasing antibiotic resistance of pathogenic bacteria, the use of medicinal herbs as antibacterial agents has attracted growing attention. Pseudomonas aeruginosa is a human opportunistic pathogen that uses quorum sensing for regulating virulence gene expression (pyocyanin, protease, and elastase production and biofilm formation). This study examined the anti-quorum sensing activity of Quercus infectoria, Zataria multiflora and Trachyspermum copticum extracts on standard P. aeruginosa strain...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28605194/discovery-of-two-bacterial-nitric-oxide-responsive-proteins-and-their-roles-in-bacterial-biofilm-regulation
#2
Sajjad Hossain, Lisa-Marie Nisbett, Elizabeth M Boon
Bacterial biofilms form when bacteria adhere to a surface and produce an exopolysaccharide matrix ( Costerton Science 1999 , 284 , 1318 ; Davies Science 1998 , 280 , 295 ; Flemming Nat. Rev. Microbiol. 2010 , 8 , 623 ). Because biofilms are resistant to antibiotics, they are problematic in many aspects of human health and welfare, causing, for instance, persistent fouling of medical implants such as catheters and artificial joints ( Brunetto Chimia 2008 , 62 , 249 ). They are responsible for chronic infections in the lungs of cystic fibrosis patients and in open wounds, such as those associated with burns and diabetes...
June 12, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28588273/myricetin-protects-galleria-mellonella-against-staphylococcus-aureus-infection-and-inhibits-multiple-virulence-factors
#3
L N Silva, G C A Da Hora, T A Soares, M S Bojer, H Ingmer, A J Macedo, D S Trentin
Staphylococcus aureus is an opportunistic pathogen related to a variety of life-threatening infections but for which antimicrobial resistance is liming the treatment options. We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. Myricetin affects both surface proteins and secreted proteins which indicate that its action is unrelated to inhibition of the agr quorum sensing system...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28487993/acinetobacter%C3%A2-baumannii-quorum-sensing-signalling-molecule-induces-the-expression-of-drug-resistance-genes
#4
Yi Dou, Fei Song, Feng Guo, Zengding Zhou, Cailian Zhu, Jun Xiang, Jingning Huan
Quorum-sensing signalling molecules such as N‑acyl homoserine lactones (AHLs) enable certain Gram‑negative bacteria to respond to environmental changes through behaviours, such as biofilm formation and flagellar movement. The present study aimed to identify Acinetobacter baumannii AHLs and assess their influence on antibiotic resistance. A clinical isolate of A. baumannii strain S (AbS) was collected from the wound of a burn patient and high‑performance liquid chromatography and tandem quadrupole or quadrupole time‑of‑flight high‑resolution mass spectrometry was used to identify AbS AHLs...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28455333/a-novel-quorum-quenching-enzyme-mediates-antibiotic-resistance
#5
Hiroyuki Kusada, Hideyuki Tamaki, Yoichi Kamagata, Satoshi Hanada, Nobutada Kimura
N-Acylhomoserine lactone acylase (AHL-acylase) is a well-known enzyme responsible for disrupting cell-cell communication (quorum sensing) in bacteria. Here we isolated and characterized a novel and unique AHL-acylase (designated MacQ) from a multidrug-resistant bacterium Acidovorax sp. MR-S7. The purified MacQ protein heterologously expressed in Escherichia coli degraded a wide variety of AHLs ranging from C6 to C14 side chains with or without 3-oxo substitutions. We also observed that AHL-mediated virulence factor production in a plant pathogen Pectobacterium carotovorum was dramatically attenuated by co-culturing with MacQ-overexpressing Escherichia coli, whereas E...
April 28, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28453568/baicalin-inhibits-biofilm-formation-attenuates-the-quorum-sensing-controlled-virulence-and-enhances-pseudomonas-aeruginosa-clearance-in-a-mouse-peritoneal-implant-infection-model
#6
Jing Luo, Biying Dong, Ke Wang, Shuangqi Cai, Tangjuan Liu, Xiaojing Cheng, Danqing Lei, Yanling Chen, Yanan Li, Jinliang Kong, Yiqiang Chen
The quorum sensing (QS) circuit plays a role in the precise regulation of genes controlling virulence factors and biofilm formation in Pseudomonas aeruginosa. QS-controlled biofilm formation by Pseudomonas aeruginosa in clinical settings has remained controversial due to emerging drug resistance; therefore, screening diverse compounds for anti-biofilm or anti-QS activities is important. This study demonstrates the ability of sub-minimum inhibitory concentrations (sub-MICs) of baicalin, an active natural compound extracted from the traditional Chinese medicinal Scutellaria baicalensis, to inhibit the formation of Pseudomonas aeruginosa biofilms and enhance the bactericidal effects of various conventional antibiotics in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28446917/shoot-the-message-not-the-messenger-combating-pathogenic-virulence-in-plants-by-inhibiting-quorum-sensing-mediated-signaling-molecules
#7
REVIEW
Ganesh Alagarasan, Kumar S Aswathy
Immunity, virulence, biofilm formation, and survival in the host environment are regulated by the versatile nature of density dependent microbial cell signaling, also called quorum sensing (QS). The QS molecules can associate with host plant tissues and, at times, cause a change in its gene expression at the downstream level through inter-kingdom cross talking. Progress in controlling QS through fungicide/bactericide in pathogenic microscopic organisms has lead to a rise of antibiotic resistance pathogens. Here, we review the application of selective quorum quenching (QQ) endophytes to control phytopathogens that are shared by most, if not all, terrestrial plant species as well as aquatic plants...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28442545/peroxisome-proliferator-activated-receptor-%C3%AE-agonists-attenuate-biofilm-formation-by-pseudomonas-aeruginosa
#8
Brahmchetna Bedi, Nicholas M Maurice, Vincent T Ciavatta, K Sabrina Lynn, Zhihong Yuan, Samuel A Molina, Myungsoo Joo, William R Tyor, Joanna B Goldberg, Michael Koval, C Michael Hart, Ruxana T Sadikot
Pseudomonas aeruginosa is a significant contributor to recalcitrant multidrug-resistant infections, especially in immunocompromised and hospitalized patients. The pathogenic profile of P. aeruginosa is related to its ability to secrete a variety of virulence factors and to promote biofilm formation. Quorum sensing (QS) is a mechanism wherein P. aeruginosa secretes small diffusible molecules, specifically acyl homo serine lactones, such as N-(3-oxo-dodecanoyl)-l-homoserine lactone (3O-C12-HSL), that promote biofilm formation and virulence via interbacterial communication...
April 25, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28438469/regulation-of-conjugative-transfer-of-plasmids-and-integrative-conjugative-elements
#9
REVIEW
Luis Alfredo Bañuelos-Vazquez, Gonzalo Torres Tejerizo, Susana Brom
Horizontal gene transfer has been recognized as one of the principal contributors to bacterial evolution and diversification. One of the mechanisms involved in this process is conjugative transfer of plasmids and Integrative Conjugative Elements (ICEs). Plasmids and ICEs often encode traits beneficial for bacterial survival in specific environments, or for the establishment of symbiosis or pathogenesis, in addition to genes allowing conjugative transfer. In this review, we analyze the mechanisms that regulate the expression of conjugative transfer genes...
April 22, 2017: Plasmid
https://www.readbyqxmd.com/read/28428780/genomic-and-transcriptomic-insights-into-calcium-carbonate-biomineralization-by-marine-actinobacterium-brevibacterium-linens-bs258
#10
Yuying Zhu, Ning Ma, Weihua Jin, Shimei Wu, Chaomin Sun
Calcium carbonate (CaCO3) biomineralization has been investigated due to its wide range of scientific and technological implications, however, the molecular mechanisms of this important geomicrobiological process are largely unknown. Here, a urease-positive marine actinobacterium Brevibacterium linens BS258 was demonstrated to effectively form CaCO3 precipitates. Surprisingly, this bacterium could also dissolve the formed CaCO3 with the increase of the Ca(2+) concentration. To disclose the mechanisms of biomineralization, the genome of B...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28402186/inhibition-of-hafnia-alvei-h4-biofilm-formation-by-the-food-additive-dihydrocoumarin
#11
Hong Man Hou, Feng Jiang, Gong Liang Zhang, Jia Y Wang, Ya H Zhu, Xin Y Liu
Quorum sensing (QS) is an intercellular signaling and gene regulatory mechanism that is implicated in food spoilage caused by bacteria. Thus, blocking QS may suppress QS-controlled phenotypes of these bacteria that are responsible for food spoilage. Biofilm formation is closely related to bacterial infection, and it is also a major mechanism responsible for the increased resistance of biofilm-associated bacteria to antimicrobial drugs. Food spoilage and biofilm formation caused by food-related bacteria have posed a significant problem for the food industry...
April 12, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28375520/global-gene-expression-profile-of-acinetobacter-baumannii-during-bacteremia
#12
Gerald L Murray, Kirill Tsyganov, Xenia P Kostoulias, Dieter M Bulach, David Powell, Darren J Creek, John D Boyce, Ian T Paulsen, Anton Y Peleg
Background.: Acinetobacter baumannii is a pathogen of major importance in intensive care units worldwide, with the potential to cause problematic outbreaks and acquire high-level resistance to antibiotics. There is an urgent need to understand the mechanisms of A. baumannii pathogenesis for the future development of novel targeted therapies. In this study we performed an in vivo transcriptomic analysis of A. baumannii isolated from a mammalian host with bacteremia. Methods...
February 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28369659/editor-s-highlight-organophosphatediazinon-altered-quorum-sensing-cell-motility-stress-response-and-carbohydrate-metabolism-of-gut-microbiome
#13
Bei Gao, Xiaoming Bian, Liang Chi, Pengcheng Tu, Hongyu Ru, Kun Lu
The gut microbiome plays a key role in energy production, immune system development, and host resistance against invading pathogens, etc. Disruption of gut bacterial homeostasis is associated with a number of human diseases. Several environmental chemicals have been reported to induce alterations of the gut microbiome. Diazinon, one of important organophosphate insecticides, has been widely used in agriculture. Diazinon and its metabolites are readily detected in different environmental settings and human urine...
June 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28289032/vrar-binding-to-the-promoter-region-of-agr-inhibits-its-function-in-vancomycin-intermediate-staphylococcus-aureus-visa-and-heterogeneous-visa
#14
Yuanyuan Dai, Wenjiao Chang, Changcheng Zhao, Jing Peng, Liangfei Xu, Huaiwei Lu, Shusheng Zhou, Xiaoling Ma
Acquisition of vancomycin resistance in Staphylococcus aureus is often accompanied by a reduction in virulence, but the mechanisms underlying this change remain unclear. The present study was undertaken to investigate this process in a clinical heterogeneous vancomycin-intermediate S. aureus (hVISA) strain, 10827; an hVISA reference strain, Mu3; and a VISA reference strain, Mu50, along with their respective series of vancomycin-induced resistant strains. In these strains, increasing MICs of vancomycin were associated with increased expression of the vancomycin resistance-associated regulator gene (vraR) and decreased expression of virulence genes (hla, hlb, and coa) and virulence-regulated genes (RNAIII, agrA, and saeR)...
May 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28264490/plakofuranolactone-as-a-quorum-quenching-agent-from-the-indonesian-sponge-plakortis-cf-lita
#15
Valeria Costantino, Gerardo Della Sala, Kumar Saurav, Roberta Teta, Rinat Bar-Shalom, Alfonso Mangoni, Laura Steindler
There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows bacteria to communicate with each other and coordinate group behaviors. A new γ-lactone that is capable of inhibiting the LasI/R QS system, plakofuranolactone (1), was discovered in the extract of the marine sponge Plakortis cf...
February 28, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28261568/pseudomonas-aeruginosa-lifestyle-a-paradigm-for-adaptation-survival-and-persistence
#16
REVIEW
M Fata Moradali, Shirin Ghods, Bernd H A Rehm
Pseudomonas aeruginosa is an opportunistic pathogen affecting immunocompromised patients. It is known as the leading cause of morbidity and mortality in cystic fibrosis (CF) patients and as one of the leading causes of nosocomial infections. Due to a range of mechanisms for adaptation, survival and resistance to multiple classes of antibiotics, infections by P. aeruginosa strains can be life-threatening and it is emerging worldwide as public health threat. This review highlights the diversity of mechanisms by which P...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28236620/influence-of-huang-lian-jie-du-decoction-on-quorum-sensing-system-of-pseudomonas-aeruginosa
#17
Fei Xia, Lihua Ye, Ping Wang, Mingwei Zhang
Context • Pseudomonas aeruginosa (P aeruginosa) is an opportunistic and nosocomial, Gram-negative pathogen that is characteristic of quorum sensing (QS) modulation. QS inhibition (QSI) is considered to be a new approach to antimicrobial treatment that may reduce issues of antibiotic resistance. Traditional Chinese herbs have been recognized as a source of QSI. Objective • This study was intended to investigate whether the Huang Lian Jie Du decoction (HLJJD) possesses the ability to produce anti-QS activity...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28221753/structure-activity-relationships-of-the-competence-stimulating-peptides-csps-in-streptococcus-pneumoniae-reveal-motifs-critical-for-intra-group-and-cross-group-comd-receptor-activation
#18
Yifang Yang, Bimal Koirala, Lucia A Sanchez, Naiya R Phillips, Sally R Hamry, Yftah Tal-Gan
Streptococcus pneumoniae is a highly recombinogenic human pathogen that utilizes the competence stimulating peptide (CSP)-based quorum sensing (QS) circuitry to acquire antibiotic resistance genes from the environment and initiate its attack on the human host. Modulation of QS in this bacterium, either inhibition or activation, can therefore be used to attenuate S. pneumoniae infectivity and slow down pneumococcal resistance development. In this study, we set to determine the molecular mechanism that drives CSP:receptor binding and identify CSP-based QS modulators with distinct activity profiles...
April 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28186134/virulence-inhibitors-from-brazilian-peppertree-block-quorum-sensing-and-abate-dermonecrosis-in-skin-infection-models
#19
Amelia Muhs, James T Lyles, Corey P Parlet, Kate Nelson, Jeffery S Kavanaugh, Alexander R Horswill, Cassandra L Quave
Widespread antibiotic resistance is on the rise and current therapies are becoming increasingly limited in both scope and efficacy. Methicillin-resistant Staphylococcus aureus (MRSA) represents a major contributor to this trend. Quorum sensing controlled virulence factors include secreted toxins responsible for extensive damage to host tissues and evasion of the immune system response; they are major contributors to morbidity and mortality. Investigation of botanical folk medicines for wounds and infections led us to study Schinus terebinthifolia (Brazilian Peppertree) as a potential source of virulence inhibitors...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164039/quorum-sensing-n-acyl-homoserine-lactones-sdia-suppresses-escherichia-coli-pseudomonas-aeruginosa-conjugation-through-inhibiting-trai-expression
#20
Yang Lu, Jianming Zeng, Binning Wu, Shunmei E, Lina Wang, Renxin Cai, Ni Zhang, Youqiang Li, Xianzhang Huang, Bin Huang, Cha Chen
Conjugation is a key mechanism for horizontal gene transfer and plays an important role in bacterial evolution, especially with respect to antibiotic resistance. However, little is known about the role of donor and recipient cells in regulation of conjugation. Here, using an Escherichia coli (SM10λπ)-Pseudomonas aeruginosa (PAO1) conjugation model, we demonstrated that deficiency of lasI/rhlI, genes associated with generation of the quorum sensing signals N-acyl homoserine lactones (AHLs) in PAO1, or deletion of the AHLs receptor SdiA in the donor SM10λπ both facilitated conjugation...
2017: Frontiers in Cellular and Infection Microbiology
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