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https://www.readbyqxmd.com/read/28818800/the-step-wise-framework-to-design-a-chromatography-based-hydrophobicity-assay-for-viral-particles
#1
Sarah A Johnson, Alison Walsh, Matthew R Brown, Scott C Lute, David J Roush, Michael S Burnham, Kurt A Brorson
A high-salt, hydrophobic interaction chromatography (HIC) method was developed to measure the relative hydrophobicity of a diverse set of solutes. Through the careful control of buffer pH and salt concentration, this assay was then used to ascertain for the first time the relative hydrophobicity values of three different bacteriophage, four mammalian viruses, and a range of biotech medicinal proteins as benchmarked to protein standards previously characterized for hydrophobicity.
August 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28818394/focal-adhesion-kinase-family-is-involved-in-matrix-contraction-by-transdifferentiated-m%C3%A3-ller-cells
#2
Rintaro Tsukahara, Kazuhiko Umazume, Kevin McDonald, Henry J Kaplan, Shigeo Tamiya
Transdifferentiated Müller cells that adopt a fibroblastic/myofibroblastic phenotype have been identified in epiretinal membranes (ERMs) in several ocular disorders, and have been implicated to play a role in the formation and/or the contraction of ERMs. We have previously demonstrated that dasatinib, a dual inhibitor of Src-family kinases and Abl kinase, can prevent matrix contraction by transdifferentiated Müller cells. In this study, we examined molecules involved in matrix contraction downstream of primary dasatinib targets...
August 14, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28813503/detectable-hiv-rna-in-semen-of-hiv-controllers
#3
Marie-Laure Chaix, Faroudy Boufassa, Candice Meyzer, Marianne Leruez-Ville, Nadia Mahjoub, Marie-Laure Nere, Philippe Genet, Claudine Duvivier, Caroline Lascoux-Combes, Olivier Lambotte, Jade Ghosn
BACKGROUND: Whether spontaneous low levels of HIV-1 RNA in blood plasma correlate with low levels of HIV-1 RNA in seminal plasma has never been investigated in HIV controller (HIC) men so far. METHODS: HIC men enrolled in the ANRS CODEX cohort were eligible for the present study if they had no symptoms of sexually transmitted infections (STI). Two paired samples of blood and semen were collected four weeks apart. HIV-RNA was quantified in blood plasma (bpVL) and in seminal plasma (spVL), and cell-associated HIV-DNA was quantified in peripheral blood mononuclear cells (PBMC) and in non-sperm cells (NSC)...
2017: PloS One
https://www.readbyqxmd.com/read/28777950/evaluation-of-the-european-leukemianet-recommendations-for-predicting-outcomes-of-patients-with-acute-myeloid-leukemia-treated-in-low-and-middle-income-countries-lmic-a-brazilian-experience
#4
Mariana Tereza de Lira Benicio, Ana Flávia Tibúrcio Ribeiro, Andre D Américo, Felipe M Furtado, Ana B Glória, Aleide S Lima, Silvana M Santos, Sandra G Xavier, Antonio R Lucena-Araujo, Evandro M Fagundes, Eduardo M Rego
BACKGROUND: Current results regarding treatment outcomes in acute myeloid leukemia (AML) point to significant differences between low- and middle-income countries (LMIC) and high-income countries (HIC). Excluding well-known socioeconomic issues, genetic markers important for prognosis have not been properly incorporated into the clinical practice so far and their usefulness outside of well-controlled clinical trials remain unknown. METHODS: Here, we assessed the clinical significance of the European LeukemiaNet (ELN) recommendations in 196 consecutive patients with AML in a real-life setting...
July 24, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28754662/shock-absorbing-aggregates-beneath-playground-equipment-grain-properties-and-moisture-content
#5
Tapani Jäniskangas, Kari P K Pylkkänen, Pauli Kolisoja
OBJECTIVES: To assess the influence of grain size distribution and moisture condition on aggregates' performance as an impact attenuation layer beneath playground equipment. SETTING AND METHODS: Impact attenuation of sands and gravels was tested using a guided headform with a uniaxial accelerometer inside. The result for impact attenuation was the acceleration value of the headform measured from four different drop heights and the Head Injury Criterion (HIC) calculated from it...
July 28, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28754002/pediatric-respiratory-support-technology-and-practices-a-global-survey
#6
Amélie O von Saint André-von Arnim, Shelina M Jamal, Grace C John-Stewart, Ndidiamaka L Musa, Joan Roberts, Larissa I Stanberry, Christopher R A Howard
OBJECTIVE: This global survey aimed to assess the current respiratory support capabilities for children with hypoxemia and respiratory failure in different economic settings. METHODS: An online, anonymous survey of medical providers with experience in managing pediatric acute respiratory illness was distributed electronically to members of the World Federation of Pediatric Intensive and Critical Care Society, and other critical care websites for 3 months. RESULTS: The survey was completed by 295 participants from 64 countries, including 28 High-Income (HIC) and 36 Low- and Middle-Income Countries (LMIC)...
July 21, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28703263/-high-and-intensive-care-three-years-later-an-evaluation-of-the-experiences-of-patients-and-employees-and-the-effect-on-coercive-measures-in-psychiatry
#7
J J P A Bierbooms, C A G Lorenz-Artz, E Pols, I M B Bongers
BACKGROUND: As part of the national campaign against the use of coercive measures in psychiatry, the Mental Health Service in Eindhoven set up the first modern high and intensive care centre (HIC) in Eindhoven in 2012. AIM: To study the progress of the numbers on coercive measures, and to evaluate the experiences of patients and treatment team members after working for three years according to the HIC model. METHOD: We analysed the registration data, carried out a short survey and conducted interviews...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28702030/enrichment-of-hla-types-and-single-nucleotide-polymorphism-associated-with-non-progression-in-a-strictly-defined-cohort-of-hiv-1-controllers
#8
Samantha J Westrop, Alexander T H Cocker, Adriano Boasso, Ann K Sullivan, Mark R Nelson, Nesrina Imami
HIV-1 controllers (HIC) are extremely rare patients with the ability to control viral replication, maintain unchanging CD4 T-cell count, and evade disease progression for extensive periods of time, in the absence of antiretroviral therapy. In order to establish the representation of key genetic correlates of atypical disease progression within a cohort of HIV-1(+) individuals who control viral replication, we examine four-digit resolution HLA type and single-nucleotide polymorphisms (SNP) previously identified to be correlated to non-progressive infection, in strictly defined HIC...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28692920/the-effect-of-motorcycle-helmet-fit-on-estimating-head-impact-kinematics-from-residual-liner-crush
#9
Stephanie J Bonin, John C Gardiner, Arzu Onar-Thomas, Shihab S Asfour, Gunter P Siegmund
Proper helmet fit is important for optimizing head protection during an impact, yet many motorcyclists wear helmets that do not properly fit their heads. The goals of this study are i) to quantify how a mismatch in headform size and motorcycle helmet size affects headform peak acceleration and head injury criteria (HIC), and ii) to determine if peak acceleration, HIC, and impact speed can be estimated from the foam liner's maximum residual crush depth or residual crush volume. Shorty-style helmets (4 sizes of a single model) were tested on instrumented headforms (4 sizes) during linear impacts between 2...
July 10, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28688663/comparing-traditional-and-novel-injury-scoring-systems-in-a-us-level-i-trauma-center-an-opportunity-for-improved-injury-surveillance-in%C3%A2-low-and-middle-income-countries
#10
Adam D Laytin, Rochelle A Dicker, Martin Gerdin, Nobhojit Roy, Bhakti Sarang, Vineet Kumar, Catherine Juillard
BACKGROUND: In most low- and middle-income countries (LMICs), the resources to accurately quantify injury severity using traditional injury scoring systems are limited. Novel injury scoring systems appear to have adequate discrimination for mortality in LMIC contexts, but they have not been rigorously compared where traditional injury scores can be accurately calculated. To determine whether novel injury scoring systems perform as well as traditional ones in a HIC with complete and comprehensive data collection...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28688616/current-possibilities-of-liquid-chromatography-for-the-characterization-of-antibody-drug-conjugates
#11
REVIEW
Balázs Bobály, Sandrine Fleury-Souverain, Alain Beck, Jean-Luc Veuthey, Davy Guillarme, Szabolcs Fekete
Antibody Drug Conjugates (ADCs) are innovative biopharmaceuticals gaining increasing attention over the last two decades. The concept of ADCs lead to new therapy approaches in numerous oncological indications as well in infectious diseases. Currently, around 60 CECs are in clinical trials indicating the expanding importance of this class of protein therapeutics. ADCs show unprecedented intrinsic heterogeneity and address new quality attributes which have to be assessed. Liquid chromatography is one of the most frequently used analytical method for the characterization of ADCs...
June 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28685036/mapping-the-global-research-landscape-and-knowledge-gaps-on-multimorbidity-a-bibliometric-study
#12
Xiaolin Xu, Gita D Mishra, Mark Jones
BACKGROUND: To summarize global research trends and activities on multimorbidity; then to assess the knowledge gaps and to identify implications for knowledge exchange between high income countries (HICs) and low- and middle- income countries (LMICs). METHODS: A comprehensive search was conducted to identify research publications on multimorbidity in the Web of Science(TM), as well as diabetes, depression, hypertension, and Chronic Obstructive Pulmonary Disease (COPD)...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28680795/social-epidemiology-and-global-mental-health-expanding-the-evidence-from-high-income-to-low-and-middle-income-countries
#13
REVIEW
Joanna Maselko
PURPOSE OF THE REVIEW: The vast majority of research on the social determinants of mental health has been generated from high-income country (HIC) populations, even as the greatest health disparities, and greatest disease burden, is observed in lower- and middle-income countries (LMICs). The goal of this review is to examine the evidence base on how key social epidemiology constructs relate to mental health in LMIC contexts. A special focus is on points of departure from the HIC knowledge base, gaps in overall understanding, and opportunities for social epidemiology to make a significant contribution...
2017: Current Epidemiology Reports
https://www.readbyqxmd.com/read/28677072/disparity-in-access-and-outcomes-for-emergency-neonatal-surgery-intestinal-atresia-in-kampala-uganda
#14
Sarah Cairo, Nasser Kakembo, Phyllis Kisa, Arlene Muzira, Maija Cheung, James Healy, Doruk Ozgediz, John Sekabira
BACKGROUND/AIM: Intestinal atresia is one of the leading causes of neonatal intestinal obstruction (NIO). The purpose of this study was to analyze the presentation and outcome of IA and compare with those from both similar and high-income country settings. PATIENTS AND METHODS: A retrospective review of prospectively collected data from patient charts and pediatric surgical database for 2012-2015 was performed. Epidemiological data and patient characteristics were analyzed and outcomes were compared with those reported in other LMICs and high-income countries (HICs)...
August 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28667291/a-biomimetic-heparinized-composite-silk-based-vascular-scaffold-with-sustained-antithrombogenicity
#15
Masoud Zamani, Mona Khafaji, Mohammad Naji, Manouchehr Vossoughi, Iran Alemzadeh, Nooshin Haghighipour
Autologous grafts, as the gold standard for vascular bypass procedures, associated with several problems that limit their usability, so tissue engineered vessels have been the subject of an increasing number of works. Nevertheless, gathering all of the desired characteristics of vascular scaffolds in the same construct has been a big challenge for scientists. Herein, a composite silk-based vascular scaffold (CSVS) was proposed to consider all the mechanical, structural and biological requirements of a small-diameter vascular scaffold...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28661713/publications-on-palliative-care-development-can-be-used-as-an-indicator-of-palliative-care-development-in-africa
#16
John Y Rhee, Eduardo Garralda, Carlos Torrado, Santiago Blanco, Ibone Ayala, Eve Namisango, Emmanuel Luyirika, Liliana de Lima, Richard A Powell, Jesús López-Fidalgo, Carlos Centeno
BACKGROUND: Palliative care (PC) research in Africa has been proposed as a fifth dimension of the World Health Organization PC Public Health Strategy. We conducted a scoping review of published articles (2005-2016) on palliative care development (PCD) in African countries. Forty-seven articles were found across 26 countries. OBJECTIVE: To study whether the number of published articles on PCD in countries in Africa can be used as an indicator of PCD. DESIGN: This is a secondary analysis of a completed scoping review...
June 29, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28622622/characterization-of-drug-load-variants-in-a-thiol-linked-antibody-drug-conjugate-using-multidimensional-chromatography
#17
Jonathan J Gilroy, Catherine M Eakin
The biological complexity associated with biotherapeutics such as antibody-drug conjugates (ADCs) requires extensive characterization to ensure product quality consistency, safety, and efficacy. ADCs generated via partial reduction of antibody interchain disulfide bonds result in a distribution of variants containing 0-8 conjugated drugs. Hydrophobic interaction chromatography (HIC) is a key analytical technique used to separate drug load variants of thiol linked ADCs and to calculate the average drug-to-antibody molar ratio (DAR)...
June 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28619413/visiting-trainees-in-global-settings-host-and-partner-perspectives-on-desirable-competencies
#18
William Cherniak, Emily Latham, Barbara Astle, Geoffrey Anguyo, Tessa Beaunoir, Joel Buenaventura, Matthew DeCamp, Karla Diaz, Quentin Eichbaum, Marius Hedimbi, Cat Myser, Charles Nwobu, Katherine Standish, Jessica Evert
BACKGROUND: Current competencies in global health education largely reflect perspectives from high-income countries (HICs). Consequently, there has been underrepresentation of the voices and perspectives of partners in low- and middle-income countries (LMICs) who supervise and mentor trainees engaged in short-term experiences in global health (STEGH). OBJECTIVE: The objective of this study was to better understand the competencies and learning objectives that are considered a priority from the perspective of partners in LMICs...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28619408/children-crossing-streets-the-cognitive-task-of-pedestrians-across-nations
#19
David C Schwebel
BACKGROUND: About 100,000 children die worldwide in pedestrian crashes, more than 90% of whom live in low- and middle-income countries (LMICs). However, most existing research on children's ability to cross the street is conducted in high-income countries (HICs). OBJECTIVE: The present study discusses 4 ways pedestrian behavior in LMICs differs from that in HICs, influencing both children's ability to cross streets safely and adult efforts to train children in pedestrian safety...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28617198/thinking-about-the-environment-and-theorising-change-how-could-life-history-strategy-theory-inform-mhealth-interventions-in-low-and-middle-income-countries
#20
Barak Morgan, Xanthe Hunt, Mark Tomlinson
BACKGROUND: There is a growing body of literature outlining the promise of mobile information and communication technologies to improve healthcare in resource-constrained contexts. METHODS: We reviewed the literature related to mobile information and communication technologies which aim to improve healthcare in resource-constrained contexts, in order to glean general observations regarding the state of mHealth in high-income countries (HIC) and low- and middle-income countries (LMIC)...
2017: Global Health Action
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