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https://www.readbyqxmd.com/read/29454115/traumatic-spinal-injury-global-epidemiology-and-worldwide-volume
#1
Ramesh Kumar, Jaims Lim, Rania A Mekary, Abbas Rattani, Michael C Dewan, Salman Y Sharif, Enrique Osorio-Fonseca, Kee B Park
BACKGROUND: Traumatic spinal injury (TSI) results from injury to bony, ligamentous and/or neurological structures of the spinal column and can cause significant morbidity and mortality. The global burden of TSI is poorly understood, so we performed a systematic review and meta-analysis to estimate the global volume of TSI. METHODS: We performed a systematic review through PubMed, Embase and Cochrane Databases on TSI studies published from 2000 to 2016. Collected data were used to perform a meta-analysis to estimate the annual incidence of TSI across World Health Organization (WHO) regions and World Bank income groups using random effect models...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29447257/access-to-health-insurance-coverage-among-sub-saharan-african-migrants-living-in-france-results-of-the-anrs-parcours-study
#2
Nicolas Vignier, Annabel Desgrées du Loû, Julie Pannetier, Andrainolo Ravalihasy, Anne Gosselin, France Lert, Nathalie Lydié, Olivier Bouchaud, Rosemary Dray Spira
BACKGROUND: Migrants' access to care depends on their health insurance coverage in the host country. We aimed to evaluate in France the dynamic and the determinants of health insurance coverage acquisition among sub-Saharan migrants. METHODS: In the PARCOURS life-event retrospective survey conducted in 2012-2013 in health-care facilities in the Paris region, data on health insurance coverage (HIC) each year since arrival in France has been collected among three groups of sub-Saharan migrants recruited in primary care centres (N = 763), centres for HIV care (N = 923) and for chronic hepatitis B care (N = 778)...
2018: PloS One
https://www.readbyqxmd.com/read/29408860/human-cytomegalovirus-epidemiology-and-relationship-to-tuberculosis-and-cardiovascular-disease-risk-factors-in-a-rural-ugandan-cohort
#3
Lisa Stockdale, Stephen Nash, Angela Nalwoga, Hannah Painter, Gershim Asiki, Helen Fletcher, Robert Newton
Human cytomegalovirus (HCMV) infection has been associated with increased mortality, specifically cardiovascular disease (CVD), in high-income countries (HICs). There is a paucity of data in low- and middle-income countries (LMICs) where HCMV seropositivity is higher. Serum samples from 2,174 Ugandan individuals were investigated for HCMV antibodies and data linked to demographic information, co-infections and a variety of CVD measurements. HCMV seropositivity was 83% by one year of age, increasing to 95% by five years...
2018: PloS One
https://www.readbyqxmd.com/read/29406894/neurologic-illness-in-zambia-a-neurointensivist-s-experience
#4
Merritt W Brown, Katie Ellen Foy, Christopher Chanda, Jacqueline Mulundika, Igor J Koralnik, Omar K Siddiqi
INTRODUCTION: Management of critically ill patients in dedicated intensive care units (ICUs) is the standard of care in high income countries (HICs), but remains uncommon in low and middle-income countries (LMICs). We sought to determine the prevalence of neurologic disorders in the ICU of a LMIC and examine if resource appropriate specialized neurocritical care training could benefit these patients. METHODS: From February to March 2017, a trained neurocritical care intensivist recorded encounters in the sole ICU at the University Teaching Hospital (UTH) in Lusaka, Zambia...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29406024/high-efficiency-and-fast-separation-of-active-proteins-by-hic-chromatographic-pie-with-sub-2%C3%A2-%C3%AE-m-polymer-packings
#5
Cong-Yu Ke, Guo-Min Lu, Wu-Juan Sun, Xun-Li Zhang
This paper reports the development of hydrophobic interaction chromatography (HIC) by synthesizing sub-2 μm polymer packings which was packed into a chromatographic pie for fast separation of native proteins at low pressures demonstrating high efficiency. Using styrene as monomer and ethylene dimethacrylate (EDMA)as swelling agent, the polystyrene seeds with an average particle size of 0.8 μm and monodisperse polymeric microspheres with a particle size of 1.5-5.0 μm were synthesized through dispersion polymerization and one-step swelling method, respectively...
February 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29401043/lay-health-worker-involvement-in-evidence-based-treatment-delivery-a-conceptual-model-to-address-disparities-in-care
#6
Miya L Barnett, Anna S Lau, Jeanne Miranda
Mobilizing lay health workers (LHWs) to deliver evidence-based treatments (EBTs) is a workforce strategy to address mental health disparities in underserved communities. LHWs can be leveraged to support access to EBTs in a variety of ways, from conducting outreach for EBTs delivered by professional providers to serving as the primary treatment providers. This critical review provides an overview of how LHW-supported or -delivered EBTs have been leveraged in low-, middle-, and high-income countries (HICs). We propose a conceptual model for LHWs to address drivers of service disparities, which relate to the overall supply of the EBTs provided and the demand for these treatments...
January 31, 2018: Annual Review of Clinical Psychology
https://www.readbyqxmd.com/read/29395810/role-of-fatty-liver-in-the-association-between-obesity-and-reduced-hepatic-insulin-clearance
#7
Y Matsubayashi, A Yoshida, H Suganami, H Ishiguro, M Yamamoto, K Fujihara, S Kodama, S Tanaka, K Kaku, H Sone
AIM: Hepatic insulin clearance (HIC) is important in regulating plasma insulin levels. Diminished HIC causes inappropriate hyperinsulinaemia, and both obesity and fatty liver (FL), which are known to decrease HIC, can be found either together in the same patient or on their own. The mechanism by which obesity reduces HIC is presumed to be mediated by FL. However, few reports have examined the role of FL in the relationship between obesity and HIC in type 2 diabetes (T2D) patients. Therefore, our study investigated the association of HIC with clinical factors, including insulin sensitivity indices, focusing on the presence or absence of FL and obesity in T2D patients...
December 11, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29380379/high-throughput-oxidation-screen-of-antibody-drug-conjugates-by-analytical-protein-a-chromatography-following-ides-digest
#8
Jakob W Buecheler, Matthias Winzer, Christian Weber, Henning Gieseler
OBJECTIVES: Oxidation of protein therapeutics is a major chemical degradation pathway which may impact bioactivity, serum half-life and stability. Therefore, oxidation is a relevant parameter which has to be monitored throughout formulation development. Methods such as HIC, RPLC and LC/MS achieve a separation of oxidized and non-oxidized species by differences in hydrophobicity. Antibody-drug conjugates (ADC) although are highly more complex due to the heterogeneity in linker, drug, drug-to-antibody ratio (DAR) and conjugation site...
January 30, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29373672/global-trends-in-cd4-cell-count-at-the-start-of-antiretroviral-therapy-collaborative-study-of-treatment-programs
#9
(no author information available yet)
Background: Early initiation of combination antiretroviral therapy (cART), at higher CD4 cell counts, prevents disease progression and reduces sexual transmission of human immunodeficiency virus (HIV). We describe the temporal trends in CD4 cell counts at the start of cART in adults from low-income, lower-middle-income, upper-middle-income, and high-income countries (LICs, LMICs, UMICs, and HICs, respectively). Methods: We included HIV-infected individuals aged ≥16 years who started cART between 2002 and 2015 in a clinic participating in the International epidemiology Databases to Evaluate AIDS (IeDEA) or the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE)...
January 25, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29372285/comparison-of-inflammatory-urine-markers-in-patients-with-interstitial-cystitis-and-overactive-bladder
#10
Akira Furuta, Tokunori Yamamoto, Yasuyuki Suzuki, Momokazu Gotoh, Shin Egawa, Naoki Yoshimura
INTRODUCTION AND HYPOTHESIS: Chronic inflammatory conditions seem to be a shared characteristic in patients with interstitial cystitis (IC) and overactive bladder (OAB). Thus, we measured 40 inflammatory urine markers in IC patients with or without Hunner's lesions (HIC and NHIC respectively) and OAB patients. METHODS: Urine was collected from consecutive HIC patients, NHIC patients, and age and gender-matched OAB patients with no history of IC, recurrent urinary tract infection or bladder cancer...
January 25, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29372146/history-indicated-cerclage-the-association-between-previous-preterm-history-and-cerclage-outcome
#11
Kyong-No Lee, Eun-Jee Whang, Kylie Hae-Jin Chang, Ji-Eun Song, Ga-Hyun Son, Keun-Young Lee
Objective: Our hospital's policy is to perform history-indicated cerclage (HIC) for pregnant patients with 1 or more second-trimester pregnancy losses. Recently, the American College of Obstetricians and Gynecologists (ACOG) guideline regarding indications for HIC was changed from 3 or more previous second-trimester fetal losses to one or more. In this study, we aimed to evaluate the efficacy of the revised guideline and to investigate the association between previous preterm history and cerclage outcome...
January 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29359465/an-efficient-scheme-for-purification-of-a-novel-recombinant-immunotoxin-rcck8pe38-for-anti-tumour-experiments
#12
Pan Hu, Song Zhang, Shi-Ying Lu, Meng Li, Jiang Chang, Meng-Yun Wang, Chang Li, Ke Zhao, Yu-Ting Guan, Yuan-Yuan Zhang, Yan-Song Li, Yu Zhou, Zeng-Shan Liu, Ou Bai, Hong-Lin Ren
rCCK8PE38 is a novel immunotoxin that targets choleystokinin B receptor (CCKBR), which is over-expressed in some tumour tissues. Although we constructeda prokaryotic expression vector to express rCCK8PE38 in our lab, thorough purification was necessary to quantitatively assess its anti-tumour effect. In this study, we established a purification protocol to obtain rCCK8PE38 with high purity from E. coli. Three different types of chromatography, including hydrophobic chromatography (HIC), ion exchange chromatography (IEC) and size exclusion chromatography (SEC), were used in combination...
January 22, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29348458/hic-5-regulates-fibrillar-adhesion-formation-to-control-tumor-extracellular-matrix-remodeling-through-interaction-with-tensin1
#13
Gregory J Goreczny, Ian J Forsythe, Christopher E Turner
The linearization of the stromal extracellular matrix (ECM) by cancer-associated fibroblasts (CAFs) facilitates tumor cell growth and metastasis. However, the mechanism by which the ECM is remodeled is not fully understood. Hic-5 (TGFβ1i1), a focal adhesion scaffold protein, has previously been reported to be crucial for stromal ECM deposition and remodeling in vivo. Herein we show that CAFs lacking Hic-5 exhibit a significant reduction in the ability to form fibrillar adhesions, a specialized form of focal adhesion that promote fibronectin fibrillogenesis...
January 19, 2018: Oncogene
https://www.readbyqxmd.com/read/29318314/synthesis-nematicidal-and-antifungal-properties-of-hybrid-heterocyclics
#14
Avula Srinivas, Malladi Sunitha, Pulluri Karthik, K Vasumathi Reddy
A new series of 5-((3aR,5S,6S,6aR)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-3-(4-fluorophenyl)-2,6-diphenyl-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazoles 10a-r was synthesized by the reaction of chalcone derivatives of 2-((3aR,5S,6S,6aR)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-3-phenylthiazolidin-4-one 9 with aryl/alkyl hydrazines. The chemical structures of newly synthesized compounds were elucidated by IR, NMR, MS and elemental analysis...
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29315774/extent-of-hunner-lesions-the-relationships-with-symptom-severity-and-clinical-parameters-in-hunner-type-interstitial-cystitis-patients
#15
Yoshiyuki Akiyama, Aya Niimi, Akira Nomiya, Yukio Yamada, Tohru Nakagawa, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
AIMS: To assess the clinical impact of Hunner lesions in patients with Hunner type interstitial cystitis (HIC). METHODS: The clinical records of 94 HIC patients who underwent their first hydrodistension (with lesion fulguration) were retrospectively reviewed. At surgery, the extent of each lesion was classified in terms of the relative involvement for the whole-bladder luminal surface; we defined four grades of involvement: <10%, 10-24%, 25-49%, and ≥50%; and two grades of severity: <25% (focal) and ≥25% (extensive)...
January 9, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29300120/extrusion-without-a-motor-a-new-take-on-the-loop-extrusion-model-of-genome-organization
#16
C A Brackley, J Johnson, D Michieletto, A N Morozov, M Nicodemi, P R Cook, D Marenduzzo
Chromatin loop extrusion is a popular model for the formation of CTCF loops and topological domains. Recent HiC data have revealed a strong bias in favour of a particular arrangement of the CTCF binding motifs that stabilize loops, and extrusion is the only model to date which can explain this. However, the model requires a motor to generate the loops, and although cohesin is a strong candidate for the extruding factor, a suitable motor protein (or a motor activity in cohesin itself) has yet to be found. Here we explore a new hypothesis: that there is no motor, and thermal motion within the nucleus drives extrusion...
January 4, 2018: Nucleus
https://www.readbyqxmd.com/read/29291171/a-comprehensive-framework-for-international-medical-programs-a-2017-consensus-statement-from-the-american-college-of-academic-international-medicine
#17
Manish Garg, Gregory L Peck, Bonnie Arquilla, Andrew C Miller, Sari E Soghoian, Harry L Anderson Iii, Christina Bloem, Michael S Firstenberg, Sagar C Galwankar, Weidun Alan Guo, Ricardo Izurieta, Elizabeth Krebs, Bhakti Hansoti, Sudip Nanda, Chinenye O Nwachuku, Benedict Nwomeh, Lorenzo Paladino, Thomas J Papadimos, Richard P Sharpe, Mamta Swaroop, Stanislaw P Stawicki
The American College of Academic International Medicine (ACAIM) represents a group of clinicians who seek to promote clinical, educational, and scientific collaboration in the area of Academic International Medicine (AIM) to address health care disparities and improve patient care and outcomes globally. Significant health care delivery and quality gaps persist between high-income countries (HICs) and low-and-middle-income countries (LMICs). International Medical Programs (IMPs) are an important mechanism for addressing these inequalities...
October 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29289958/regulatory-variants-of-foxg1-in-the-context-of-its-topological-domain-organisation
#18
Mana M Mehrjouy, Ana Carolina S Fonseca, Nadja Ehmke, Giorgio Paskulin, Antonio Novelli, Francesco Benedicenti, Maria Antonietta Mencarelli, Alessandra Renieri, Tiffany Busa, Chantal Missirian, Claus Hansen, Kikue Terada Abe, Carlos Eduardo Speck-Martins, Angela M Vianna-Morgante, Mads Bak, Niels Tommerup
FOXG1 syndrome is caused by FOXG1 intragenic point mutations, or by long-range position effects (LRPE) of intergenic structural variants. However, the size of the FOXG1 regulatory landscape is uncertain, because the associated topologically associating domain (TAD) in fibroblasts is split into two domains in embryonic stem cells (hESC). Indeed, it has been suggested that the pathogenetic mechanism of deletions that remove the stem-cell-specific TAD boundary may be enhancer adoption due to ectopic activity of enhancer(s) located in the distal hESC-TAD...
December 30, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29282513/international-study-of-the-epidemiology-of-paediatric-trauma-papsa-research-study
#19
Catherine J Bradshaw, Ashwath S Bandi, Zahid Muktar, Muhammad A Hasan, Tanvir K Chowdhury, Tahmina Banu, Mesay Hailemariam, Florence Ngu, David Croaker, Rouma Bankolé, Tunde Sholadoye, Oluwole Olaomi, Emmanuel Ameh, Antonio Di Cesare, Ernesto Leva, Yona Ringo, Lukman Abdur-Rahman, Ramy Salama, Essam Elhalaby, Helen Perera, Christopher Parsons, Stewart Cleeve, Alp Numanoglu, Sebastian Van As, Shilpa Sharma, Kokila Lakhoo
OBJECTIVES: Trauma is a significant cause of morbidity and mortality worldwide. The literature on paediatric trauma epidemiology in low- and middle-income countries (LMICs) is limited. This study aims to gather epidemiological data on paediatric trauma. METHODS: This is a multicentre prospective cohort study of paediatric trauma admissions, over 1 month, from 15 paediatric surgery centres in 11 countries. Epidemiology, mechanism of injury, injuries sustained, management, morbidity and mortality data were recorded...
December 28, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29282008/pricing-appraisal-of-anti-cancer-drugs-in-the-south-east-asian-western-pacific-and-east-mediterranean-region
#20
Shahrzad Salmasi, Kah Seng Lee, Long Chiau Ming, Chin Fen Neoh, Mahmoud E Elrggal, Zaheer-Ud- Din Babar, Tahir Mehmood Khan, Muhammad Abdul Hadi
BACKGROUND: Globally, cancer is one of the leading causes of mortality. High treatment cost, partly owing to higher prices of anti-cancer drugs, presents a significant burden on patients and healthcare systems. The aim of the present study was to survey and compare retail prices of anti-cancer drugs between high, middle and low income countries in the South-East Asia, Western Pacific and Eastern Mediterranean regions. METHODS: Cross-sectional survey design was used for the present study...
December 28, 2017: BMC Cancer
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