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https://www.readbyqxmd.com/read/28320168/a-systematic-comparison-of-key-features-of-ischemic-stroke-prevention-guidelines-in-low-and-middle-income-vs-high-income-countries
#1
REVIEW
Hernán Bayona, Mayowa Owolabi, Wuwei Feng, Paul Olowoyo, Joseph Yaria, Rufus Akinyemi, James R Sawers, Bruce Ovbiagele
BACKGROUND AND PURPOSE: Implementation of contextually appropriate, evidence-based, expert-recommended stroke prevention guideline is particularly important in Low-Income Countries (LMICs), which bear disproportional larger burden of stroke while possessing fewer resources. However, key quality characteristics of guidelines issued in LMICs compared with those in High-Income Countries (HICs) have not been systematically studied. We aimed to compare important features of stroke prevention guidelines issued in these groups...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28297074/cost-effectiveness-of-cervical-cancer-screening-methods-in-low-and-middle-income-countries-a-systematic-review
#2
REVIEW
Alex K Mezei, Heather L Armstrong, Heather N Pedersen, Nicole G Campos, Sheona M Mitchell, Musa Sekikubo, Josaphat K Byamugisha, Jane J Kim, Stirling Bryan, Gina S Ogilvie
The incidence of cervical cancer in low- and middle-income countries (LMICs) is five times higher than that observed in high-income countries (HICs). This discrepancy is largely attributed to the implementation of cytology-based screening programmes in HICs. However, due to reduced health system infrastructure requirements, HPV testing (self- and provider-collected), and visual inspection with acetic acid (VIA) have been proposed as alternatives that may be better suited to LMICs. Knowing the relative value of different screening options can inform policy and the development of sustainable prevention programs...
March 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28295193/guidelines-in-lower-middle-income-countries
#3
REVIEW
Edeghonghon Olayemi, Eugenia V Asare, Amma A Benneh-Akwasi Kuma
Guidelines include recommendations intended to optimize patient care; used appropriately, they make healthcare consistent and efficient. In most lower-middle income countries (LMICs), there is a paucity of well-designed guidelines; as a result, healthcare workers depend on guidelines developed in Higher Income Countries (HICs). However, local guidelines are more likely to be implemented because they are applicable to the specific environment; and consider factors such as availability of resources, specialized skills and local culture...
March 14, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28292367/myofibroblast-mediated-contraction
#4
Wae M Al Kattan, Seham F Alarfaj, Bayan M Alnooh, Hadeel F Alsaif, Hayfa S Alabdul Karim, Noha M Al-Qattan, Mohammad M Al-Qattan, Amel A F El-Sayed
Myofibroblast-mediated contraction is viewed as a cycle of four steps. The first step is stimulation of myofibroblasts by lysophospholipids leading to the activation of G proteins and ending with contraction of the actin-myosin complex. The next step is the transmission of the intracellular contractile force at the focal adhesions of myofibroblasts; a step that involves talin, vinculin, paxillin, Hic-5, and the integrin receptors. In the third step, fibronectin will act as the extracellular link between the integrin receptors and the extracellular collagen...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28287543/modified-drop-tower-impact-tests-for-american-football-helmets
#5
G Alston Rush, R Prabhu, Gus A Rush, Lakiesha N Williams, M F Horstemeyer
A modified National Operating Committee on Standards for Athletic Equipment (NOCSAE) test method for American football helmet drop impact test standards is presented that would provide better assessment of a helmet's on-field impact performance by including a faceguard on the helmet. In this study, a merger of faceguard and helmet test standards is proposed. The need for a more robust systematic approach to football helmet testing procedures is emphasized by comparing representative results of the Head Injury Criterion (HIC), Severity Index (SI), and peak acceleration values for different helmets at different helmet locations under modified NOCSAE standard drop tower tests...
February 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28285990/classification-of-causes-and-associated-conditions-for-stillbirths-and-neonatal-deaths
#6
REVIEW
Vicki Flenady, Aleena M Wojcieszek, David Ellwood, Susannah Hopkins Leisher, Jan Jaap H M Erwich, Elizabeth S Draper, Elizabeth M McClure, Hanna E Reinebrant, Jeremy Oats, Lesley McCowan, Alison L Kent, Glenn Gardener, Adrienne Gordon, David Tudehope, Dimitrios Siassakos, Claire Storey, Jane Zuccollo, Jane E Dahlstrom, Katherine J Gold, Sanne Gordijn, Karin Pettersson, Vicki Masson, Robert Pattinson, Jason Gardosi, T Yee Khong, J Frederik Frøen, Robert M Silver
Accurate and consistent classification of causes and associated conditions for perinatal deaths is essential to inform strategies to reduce the five million which occur globally each year. With the majority of deaths occurring in low- and middle-income countries (LMICs), their needs must be prioritised. The aim of this paper is to review the classification of perinatal death, the contemporary classification systems including the World Health Organization's International Classification of Diseases - Perinatal Mortality (ICD-PM), and next steps...
March 9, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28283116/bidirectional-exchanges-of-medical-students-between-institutional-partners-in-global-health-clinical-education-programs-putting-ethical-principles-into-practice
#7
Robert Rohrbaugh, Anne Kellett, Michael J Peluso
BACKGROUND: One-third of US medical students participate in global health (GH) education, and approximately one-quarter of US medical schools have structured programs that offer special recognition in GH. GH clinical electives (GHCEs) are opportunities for students to experience a medical system and culture different from their own. GHCEs are administered through institutional affiliation agreements, often between an institution in a high-income country (HIC) and one in a low- or middle-income country (LMIC)...
September 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28281090/against-cursory-treatments-in-ethics-of-medical-migration-from-underserved-countries
#8
Yusuf Yuksekdag
In a recent paper, Mpofu, Sen Gupta, and Hays (2016) attempt to outline the obligations of recruiting high-income countries (HICs) and would-be emigrant health workers (HWs) to tackle the effects of mass exodus of health workers from underserved regions. They reconstruct (i) Rawlsian and Kantian global justice approaches to argue for moral obligations of HICs and (ii) an individual justice approach to point to non-enforceable social responsibilities of HWs to assist their compatriots. This critical commentary demonstrates that the argumentation within their individual justice approach is problematic on the basis of three reasons: (1) their discussion under-theorizes and undervalues individual rights and more specifically the right to exit, (2) their argumentation in the latter part, even if problematically, does rather point to moral obligations in lieu of social responsibilities of HWs, and (3) they overlook many other important freedoms, interests, and values pertinent to the issue of retention...
March 9, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28270187/multiplex-serum-protein-analysis-reveals-potential-mechanisms-and-markers-of-response-to-hyperimmune-caprine-serum-in-systemic-sclerosis
#9
Niamh Quillinan, Kristina E N Clark, Bryan Youl, Jeffrey Vernes, Deirdre McIntosh, Syed Haq, Christopher P Denton
BACKGROUND: Hyperimmune caprine serum (HICS) is a novel biological therapy with potential benefit for skin in established diffuse cutaneous systemic sclerosis. Here we report multiplex protein analysis of blood samples from a placebo-controlled phase II clinical trial and explore mechanisms of action and markers of response. METHODS: Patients were treated with HICS (n = 10) or placebo (n = 10) over 26 weeks, with follow-up open-label treatment to 52 weeks in 14 patients...
March 7, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28262157/autism-behavioural-interventional-research-in-low-resource-settings-overcoming-prevailing-challenges-an-asian-perspective
#10
REVIEW
M Harshini, K Preeti
Acceleration of Autism interventional research is evident in high-income countries (HIC), however, remains limited in low-resource settings. Though studies have established efficacy of behavioural interventions for Autism spectrum disorder, conducting behavioural interventional research in low resource setting poses unique challenges in economic, ethical and cultural facets. This brief communication discusses the prevailing challenges in low resource setting in designing and testing the efficacy of behaviour interventional model that is generalizable to primary care settings...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28257319/contextual-challenges-to-safe-surgery-in-a-resource-limited-setting-a-multicenter-multiprofessional-qualitative-study
#11
John W Scott, Yihan Lin, Georges Ntakiyiruta, Zeta A Mutabazi, William Austin Davis, Megan A Morris, Douglas S Smink, Robert Riviello, Steven Yule
OBJECTIVES: Safe surgery should be available to all patients, no matter the setting. The purpose of this study was to explore the contextual-specific challenges to safe surgical care encountered by surgeons and surgical teams in many in low- and middle-income countries (LMICs), and to understand the ways in which surgical teams overcome them. BACKGROUND: Optimal surgical performance is highly complex and requires providers to integrate and communicate information regarding the patient, task, team, and environment to coordinate team-based care that is timely, effective, and safe...
March 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28256687/-reliability-and-stability-in-the-diagnosis-of-high-intellectual-capacity
#12
S Sastre-Riba, A Castello-Tarrida
INTRODUCTION: From a differential perspective it is essential to identify high intellectual capacity (HIC) as a valuable personal and social resource. A valid, stable and reliable metric approach is needed that prevents both false positives and non-detection, thus facilitating the planning and implementation of educational intervention programmes that enable the individual to express his or her personal well-being and potential. AIM: To explore the reliability and stability of the metric approach to HIC at different times of measurement...
February 24, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28251841/topologically-associated-domains-a-successful-scaffold-for-the-evolution-of-gene-regulation-in-animals
#13
REVIEW
Rafael D Acemel, Ignacio Maeso, José Luis Gómez-Skarmeta
The evolution of gene regulation is considered one of the main drivers causing the astonishing morphological diversity in the animal kingdom. Gene regulation in animals heavily depends upon cis-regulatory elements, discrete pieces of DNA that interact with target promoters to regulate gene expression. In the last years, Chromosome Conformation Capture experiments (4C-seq, 5C, and HiC) in several organisms have shown that the genomes of many bilaterian animals are organized in the 3D chromatin space in compartments called topologically associated domains (TADs)...
March 2, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28245839/a-systematic-review-of-economic-evaluations-of-chw-interventions-aimed-at-improving-child-health-outcomes
#14
REVIEW
L Nkonki, A Tugendhaft, K Hofman
Evidence of the cost-effectiveness of community health worker interventions is pertinent for decision-makers and programme planners who are turning to community services in order to strengthen health systems in the context of the momentum generated by strategies to support universal health care, the post-2015 Sustainable Development Goal agenda.We conducted a systematic review of published economic evaluation studies of community health worker interventions aimed at improving child health outcomes. Four public health and economic evaluation databases were searched for studies that met the inclusion criteria: National Health Service Economic Evaluation Database (NHS EED), Cochrane, Paediatric Economic Evaluation Database (PEED), and PubMed...
February 28, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28241770/application-of-the-consolidated-framework-for-implementation-research-to-assess-factors-that-may-influence-implementation-of-tobacco-use-treatment-guidelines-in-the-viet-nam-public-health-care-delivery-system
#15
Nancy VanDevanter, Pritika Kumar, Nam Nguyen, Linh Nguyen, Trang Nguyen, Frances Stillman, Bryan Weiner, Donna Shelley
BACKGROUND: Services to treat tobacco dependence are not readily available to smokers in low-middle income countries (LMICs) where smoking prevalence remains high. We are conducting a cluster randomized controlled trial comparing the effectiveness of two strategies for implementing tobacco use treatment guidelines in 26 community health centers (CHCs) in Viet Nam. Guided by the Consolidated Framework for Implementation Research (CFIR), prior to implementing the trial, we conducted formative research to (1) identify factors that may influence guideline implementation and (2) inform further modifications to the intervention that may be necessary to translate a model of care delivery from a high-income country (HIC) to the local context of a LMIC...
February 28, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28231420/serum-ferritin-concentration-predicts-hepatic-fibrosis-better-than-hepatic-iron-concentration-in-human-hfe-hemochromatosis
#16
Marnie J Wood, Darrell H G Crawford, Leesa F Wockner, Lawrie W Powell, Grant A Ramm
BACKGROUND & AIMS: Ferritin is purported to have proinflammatory and profibrogenic effects on hepatic stellate cells. Thus, rather than acting as a passive indicator of hepatic iron concentration (HIC) in hemochromatosis, ferritin may directly influence fibrosis. This study evaluated whether serum ferritin is a better predictor of hepatic fibrosis compared to variables previously associated with increased fibrosis risk in hemochromatosis. METHODS: We identified 291 C282Y HFE-homozygous patients who had undergone liver biopsy for histological fibrosis staging and measurement of HIC...
February 23, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28223433/global-cancer-in-women-burden-and-trends
#17
Lindsey A Torre, Farhad Islami, Rebecca L Siegel, Elizabeth M Ward, Ahmedin Jemal
There are striking disparities in the global cancer burden in women, yet few publications highlight cancer occurrence in this population, particularly for cancers that are not sex-specific. This paper, the first in a series of two, summarizes the current burden, trends, risk factors, prevention, early detection, and survivorship of all cancers combined and seven sites (breast, cervix, uterine corpus, ovary, colorectum, lung, and liver) that account for about 60% of the cancer burden among women worldwide, using data from the International Agency for Research on Cancer...
February 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28209711/serotype-3-pneumococci-sequester-platelet-derived-human-thrombospondin-1-via-the-adhesin-and-immune-evasion-protein-hic
#18
Ulrike Binsker, Thomas P Kohler, Krystin Krauel, Sylvia Kohler, Johanna Habermeyer, Hansjörg Schwertz, Sven Hammerschmidt
Streptococcus pneumoniae serotype 3 strains emerge frequently within clinical isolates of invasive diseases. Bacterial invasion into deeper tissues is associated with colonization and immune evasion mechanisms. Thus, pneumococci express a versatile repertoire of surface proteins sequestering and interacting specifically with components of the human extracellular matrix and serum. Hic, a PspC-like pneumococcal surface protein possesses vitronectin and Factor H binding activity. Here, we show that heterologously expressed Hic domains interact, similar to the classical PspC molecule, with human matricellular thrombospondin-1 (hTSP-1)...
February 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28186011/mapping-local-codes-to-read-codes
#19
Wilfred Bonney, James Galloway, Christopher Hall, Mikhail Ghattas, Leandro Tramma, Thomas Nind, Louise Donnelly, Emily Jefferson, Alexander Doney
Background & Objectives: Legacy laboratory test codes make it difficult to use clinical datasets for meaningful translational research, where populations are followed for disease risk and outcomes over many years. The Health Informatics Centre (HIC) at the University of Dundee hosts continuous biochemistry data from the clinical laboratories in Tayside and Fife dating back as far as 1987. However, the HIC-managed biochemistry dataset is coupled with incoherent sample types and unstandardised legacy local test codes, which increases the complexity of using the dataset for reasonable population health outcomes...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28174236/merkel-cell-carcinomas-arising-in-autoimmune-disease-affected-patients-treated-with-biological-drugs-including-tnf
#20
John C Rotondo, Ilaria Bononi, Andrea Puozzo, Marcello Govoni, Valentina Foschi, Giovanni Lanza, Roberta Gafà, Antoine Touzè, Pauline Gaboriaud, Rita Selvatici, Fernanda Martini, Mauro Tognon
PURPOSE: The purpose of this investigation was to characterize Merkel cell carcinomas (MCC) arising in patients affected by auto-immune diseases, treated with biologic drugs. EXPERIMENTAL DESIGN: Serum samples from MCC patients were analyzed for the presence and titer of antibodies against antigens of the oncogenic Merkel cell polyomavirus (MCPyV). IgG antibodies against the viral oncoproteins Large T (LT) and small t (ST) antigens and the viral capsid protein 1 were analyzed by indirect E...
February 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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