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https://www.readbyqxmd.com/read/28703263/-high-and-intensive-care-three-years-later-an-evaluation-of-the-experiences-of-patients-and-employees-and-the-effect-on-coercive-measures-in-psychiatry
#1
J J P A Bierbooms, C A G Lorenz-Artz, E Pols, I M B Bongers
BACKGROUND: As part of the national campaign against the use of coercive measures in psychiatry, the Mental Health Service in Eindhoven set up the first modern high and intensive care centre (HIC) in Eindhoven in 2012. AIM: To study the progress of the numbers on coercive measures, and to evaluate the experiences of patients and treatment team members after working for three years according to the HIC model. METHOD: We analysed the registration data, carried out a short survey and conducted interviews...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28702030/enrichment-of-hla-types-and-single-nucleotide-polymorphism-associated-with-non-progression-in-a-strictly-defined-cohort-of-hiv-1-controllers
#2
Samantha J Westrop, Alexander T H Cocker, Adriano Boasso, Ann K Sullivan, Mark R Nelson, Nesrina Imami
HIV-1 controllers (HIC) are extremely rare patients with the ability to control viral replication, maintain unchanging CD4 T-cell count, and evade disease progression for extensive periods of time, in the absence of antiretroviral therapy. In order to establish the representation of key genetic correlates of atypical disease progression within a cohort of HIV-1(+) individuals who control viral replication, we examine four-digit resolution HLA type and single-nucleotide polymorphisms (SNP) previously identified to be correlated to non-progressive infection, in strictly defined HIC...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28692920/the-effect-of-motorcycle-helmet-fit-on-estimating-head-impact-kinematics-from-residual-liner-crush
#3
Stephanie J Bonin, John C Gardiner, Arzu Onar-Thomas, Shihab S Asfour, Gunter P Siegmund
Proper helmet fit is important for optimizing head protection during an impact, yet many motorcyclists wear helmets that do not properly fit their heads. The goals of this study are i) to quantify how a mismatch in headform size and motorcycle helmet size affects headform peak acceleration and head injury criteria (HIC), and ii) to determine if peak acceleration, HIC, and impact speed can be estimated from the foam liner's maximum residual crush depth or residual crush volume. Shorty-style helmets (4 sizes of a single model) were tested on instrumented headforms (4 sizes) during linear impacts between 2...
July 7, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28688663/comparing-traditional-and-novel-injury-scoring-systems-in-a-us-level-i-trauma-center-an-opportunity-for-improved-injury-surveillance-in%C3%A2-low-and-middle-income-countries
#4
Adam D Laytin, Rochelle A Dicker, Martin Gerdin, Nobhojit Roy, Bhakti Sarang, Vineet Kumar, Catherine Juillard
BACKGROUND: In most low- and middle-income countries (LMICs), the resources to accurately quantify injury severity using traditional injury scoring systems are limited. Novel injury scoring systems appear to have adequate discrimination for mortality in LMIC contexts, but they have not been rigorously compared where traditional injury scores can be accurately calculated. To determine whether novel injury scoring systems perform as well as traditional ones in a HIC with complete and comprehensive data collection...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28688616/current-possibilities-of-liquid-chromatography-for-the-characterization-of-antibody-drug-conjugates
#5
REVIEW
Balázs Bobály, Sandrine Fleury-Souverain, Alain Beck, Jean-Luc Veuthey, Davy Guillarme, Szabolcs Fekete
Antibody Drug Conjugates (ADCs) are innovative biopharmaceuticals gaining increasing attention over the last two decades. The concept of ADCs lead to new therapy approaches in numerous oncological indications as well in infectious diseases. Currently, around 60 CECs are in clinical trials indicating the expanding importance of this class of protein therapeutics. ADCs show unprecedented intrinsic heterogeneity and address new quality attributes which have to be assessed. Liquid chromatography is one of the most frequently used analytical method for the characterization of ADCs...
June 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28685036/mapping-the-global-research-landscape-and-knowledge-gaps-on-multimorbidity-a-bibliometric-study
#6
Xiaolin Xu, Gita D Mishra, Mark Jones
BACKGROUND: To summarize global research trends and activities on multimorbidity; then to assess the knowledge gaps and to identify implications for knowledge exchange between high income countries (HICs) and low- and middle- income countries (LMICs). METHODS: A comprehensive search was conducted to identify research publications on multimorbidity in the Web of Science(TM), as well as diabetes, depression, hypertension, and Chronic Obstructive Pulmonary Disease (COPD)...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28680795/social-epidemiology-and-global-mental-health-expanding-the-evidence-from-high-income-to-low-and-middle-income-countries
#7
REVIEW
Joanna Maselko
PURPOSE OF THE REVIEW: The vast majority of research on the social determinants of mental health has been generated from high-income country (HIC) populations, even as the greatest health disparities, and greatest disease burden, is observed in lower- and middle-income countries (LMICs). The goal of this review is to examine the evidence base on how key social epidemiology constructs relate to mental health in LMIC contexts. A special focus is on points of departure from the HIC knowledge base, gaps in overall understanding, and opportunities for social epidemiology to make a significant contribution...
2017: Current Epidemiology Reports
https://www.readbyqxmd.com/read/28677072/disparity-in-access-and-outcomes-for-emergency-neonatal-surgery-intestinal-atresia-in-kampala-uganda
#8
Sarah Cairo, Nasser Kakembo, Phyllis Kisa, Arlene Muzira, Maija Cheung, James Healy, Doruk Ozgediz, John Sekabira
BACKGROUND/AIM: Intestinal atresia is one of the leading causes of neonatal intestinal obstruction (NIO). The purpose of this study was to analyze the presentation and outcome of IA and compare with those from both similar and high-income country settings. PATIENTS AND METHODS: A retrospective review of prospectively collected data from patient charts and pediatric surgical database for 2012-2015 was performed. Epidemiological data and patient characteristics were analyzed and outcomes were compared with those reported in other LMICs and high-income countries (HICs)...
August 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28667291/a-biomimetic-heparinized-composite-silk-based-vascular-scaffold-with-sustained-antithrombogenicity
#9
Masoud Zamani, Mona Khafaji, Mohammad Naji, Manouchehr Vossoughi, Iran Alemzadeh, Nooshin Haghighipour
Autologous grafts, as the gold standard for vascular bypass procedures, associated with several problems that limit their usability, so tissue engineered vessels have been the subject of an increasing number of works. Nevertheless, gathering all of the desired characteristics of vascular scaffolds in the same construct has been a big challenge for scientists. Herein, a composite silk-based vascular scaffold (CSVS) was proposed to consider all the mechanical, structural and biological requirements of a small-diameter vascular scaffold...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28661713/publications-on-palliative-care-development-can-be-used-as-an-indicator-of-palliative-care-development-in-africa
#10
John Y Rhee, Eduardo Garralda, Carlos Torrado, Santiago Blanco, Ibone Ayala, Eve Namisango, Emmanuel Luyirika, Liliana de Lima, Richard A Powell, Jesús López-Fidalgo, Carlos Centeno
BACKGROUND: Palliative care (PC) research in Africa has been proposed as a fifth dimension of the World Health Organization PC Public Health Strategy. We conducted a scoping review of published articles (2005-2016) on palliative care development (PCD) in African countries. Forty-seven articles were found across 26 countries. OBJECTIVE: To study whether the number of published articles on PCD in countries in Africa can be used as an indicator of PCD. DESIGN: This is a secondary analysis of a completed scoping review...
June 29, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28622622/characterization-of-drug-load-variants-in-a-thiol-linked-antibody-drug-conjugate-using-multidimensional-chromatography
#11
Jonathan J Gilroy, Catherine M Eakin
The biological complexity associated with biotherapeutics such as antibody-drug conjugates (ADCs) requires extensive characterization to ensure product quality consistency, safety, and efficacy. ADCs generated via partial reduction of antibody interchain disulfide bonds result in a distribution of variants containing 0-8 conjugated drugs. Hydrophobic interaction chromatography (HIC) is a key analytical technique used to separate drug load variants of thiol linked ADCs and to calculate the average drug-to-antibody molar ratio (DAR)...
June 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28619413/visiting-trainees-in-global-settings-host-and-partner-perspectives-on-desirable-competencies
#12
William Cherniak, Emily Latham, Barbara Astle, Geoffrey Anguyo, Tessa Beaunoir, Joel Buenaventura, Matthew DeCamp, Karla Diaz, Quentin Eichbaum, Marius Hedimbi, Cat Myser, Charles Nwobu, Katherine Standish, Jessica Evert
BACKGROUND: Current competencies in global health education largely reflect perspectives from high-income countries (HICs). Consequently, there has been underrepresentation of the voices and perspectives of partners in low- and middle-income countries (LMICs) who supervise and mentor trainees engaged in short-term experiences in global health (STEGH). OBJECTIVE: The objective of this study was to better understand the competencies and learning objectives that are considered a priority from the perspective of partners in LMICs...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28619408/children-crossing-streets-the-cognitive-task-of-pedestrians-across-nations
#13
David C Schwebel
BACKGROUND: About 100,000 children die worldwide in pedestrian crashes, more than 90% of whom live in low- and middle-income countries (LMICs). However, most existing research on children's ability to cross the street is conducted in high-income countries (HICs). OBJECTIVE: The present study discusses 4 ways pedestrian behavior in LMICs differs from that in HICs, influencing both children's ability to cross streets safely and adult efforts to train children in pedestrian safety...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28617198/thinking-about-the-environment-and-theorising-change-how-could-life-history-strategy-theory-inform-mhealth-interventions-in-low-and-middle-income-countries
#14
Barak Morgan, Xanthe Hunt, Mark Tomlinson
BACKGROUND: There is a growing body of literature outlining the promise of mobile information and communication technologies to improve healthcare in resource-constrained contexts. METHODS: We reviewed the literature related to mobile information and communication technologies which aim to improve healthcare in resource-constrained contexts, in order to glean general observations regarding the state of mHealth in high-income countries (HIC) and low- and middle-income countries (LMIC)...
2017: Global Health Action
https://www.readbyqxmd.com/read/28612841/il-17-driven-intestinal-fibrosis-is-inhibited-by-itch-mediated-ubiquitination-of-hic-5
#15
J Paul, A K Singh, M Kathania, T L Elviche, M Zeng, V Basrur, A L Theiss, K Venuprasad
Intestinal fibrosis is a major complication in inflammatory bowel diseases, but the regulatory mechanism that inhibits fibrosis remains unclear. Here we demonstrate that Itch(-/-)myofibroblasts express increased amounts of profibrotic collagen type I and α-SMA in response to IL-17. Mechanistically, we demonstrate that Itch directly binds to HIC-5 and targets it for K63-linked ubiquitination to inhibit IL-17-driven intestinal fibrosis. Reconstitution of Itch(-/-) myofibroblasts with wild-type Itch but not the Itch-C830A mutant normalized the expression of profibrotic genes...
June 14, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28597232/factors-associated-to-medication-consumption-among-the-immigrant-population-residing-in-spain
#16
Díaz-Rodríguez Dania Rocío, Hernández-Barrera Valentín, Jiménez-Trujillo Isabel, Carrasco-Garrido Pilar
We aimed to determine the prevalence of medication use by the immigrant population residing in Spain, and to identify the factors associated with this consumption. Descriptive cross-sectional study was performed using secondary data retrieved from the 2012 Spanish National Health Survey (SNHS). Using logistic multivariate regression analysis, three models were generated: one for immigrants from high income countries (HIC), another for immigrants from low income countries (LIC), and a third one for the native population...
June 8, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28595240/toll-like-receptor-7-is-overexpressed-in-the-bladder-of-hunner-type-interstitial-cystitis-and-its-activation-in-the-mouse-bladder-can-induce-cystitis-and-bladder-pain
#17
Koji Ichihara, Naoki Aizawa, Yoshiyuki Akiyama, Jun Kamei, Naoya Masumori, Karl-Erik Andersson, Yukio Homma, Yasuhiko Igawa
Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and nociception using mice. Bladder biopsy specimens were obtained from patients with HIC. Specimens from the noncancerous portion of the bladder of patients with bladder cancer served as controls. The specimens were examined by immunohistochemistry and real-time polymerase chain reaction of TLR7...
May 6, 2017: Pain
https://www.readbyqxmd.com/read/28587113/the-therapeutic-targeting-of-hgf-c-met-signaling-in-hepatocellular-carcinoma-alternative-approaches
#18
REVIEW
Chi-Tan Hu, Jia-Ru Wu, Chuan-Chu Cheng, Wen-Sheng Wu
The poor prognosis of hepatocellular carcinoma (HCC), one of the most devastating cancers worldwide, is due to frequent recurrence and metastasis. Among the metastatic factors in the tumor microenvironment, hepatocyte growth factor (HGF) has been well known to play critical roles in tumor progression, including HCC. Therefore, c-Met is now regarded as the most promising therapeutic target for the treatment of HCC. However, there are still concerns about resistance and the side effects of using conventional inhibitors of c-Met, such as tyrosine kinase inhibitors...
May 26, 2017: Cancers
https://www.readbyqxmd.com/read/28584850/a-subset-of-extreme-human-immunodeficiency-virus-hiv-controllers-is-characterized-by-a-small-hiv-blood-reservoir-and-a-weak-t-cell-activation-level
#19
Etienne Canouï, Camille Lécuroux, Véronique Avettand-Fenoël, Marine Gousset, Christine Rouzioux, Asier Saez-Cirion, Laurence Meyer, Faroudy Boufassa, Olivier Lambotte, Nicolas Noël
BACKGROUND: Human immunodeficiency virus controllers (HICs) form a heterogeneous group of patients with regard to formal definitions, immunologic characteristics, and changes over time in viral load. PATIENTS AND METHODS: The HICs with undetectable viral load ([uHICs] ie, for whom a viral load had never been detected with routine assays; n = 52) were compared with 178 HICs with blips during the follow up (bHICs). Clinical characteristics, ultrasensitive HIV-ribonucleic acid (RNA) and HIV-deoxyribonucleic acid (DNA) loads, HIV1-Western blot profiles, and immune parameters were analyzed...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28574165/synergistic-chemo-enzymatic-hydrolysis-of-poly-ethylene-terephthalate-from-textile-waste
#20
Felice Quartinello, Simona Vajnhandl, Julija Volmajer Valh, Thomas J Farmer, Bojana Vončina, Alexandra Lobnik, Enrique Herrero Acero, Alessandro Pellis, Georg M Guebitz
Due to the rising global environment protection awareness, recycling strategies that comply with the circular economy principles are needed. Polyesters are among the most used materials in the textile industry; therefore, achieving a complete poly(ethylene terephthalate) (PET) hydrolysis in an environmentally friendly way is a current challenge. In this work, a chemo-enzymatic treatment was developed to recover the PET building blocks, namely terephthalic acid (TA) and ethylene glycol. To monitor the monomer and oligomer content in solid samples, a Fourier-transformed Raman method was successfully developed...
June 2, 2017: Microbial Biotechnology
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