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https://www.readbyqxmd.com/read/28102701/the-effect-of-pre-crash-velocity-reduction-on-occupant-response-using-a-human-body-finite-element-model
#1
B Guleyupoglu, J Schap, K D Kusano, F S Gayzik
OBJECTIVE: The objective of this study is to use a validated finite element model of the human body and a certified model of an ATD to evaluate the effect of simulated pre-crash braking on driver kinematics, restraint loads, body loads and computed injury criteria in four commonly-injured body regions. METHODS: The Global Human Body Models Consortium (GHBMC) 50th percentile male occupant (M50-O) and the Humanetics Hybrid-III 50(th) percentile models were gravity settled in the driver position of a generic interior equipped with an advanced three point belt and driver airbag...
January 19, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28102533/hospital-incident-command-first-responders-or-receiving-centers
#2
Brian Fletcher, Amanda Knight, Brandy Pockrus, Matthew J Wain, Kathy Lehman-Huskamp
OBJECTIVES: (1) Propose a conceptual model of an alternative hospital incident management system (HIMS) that integrates concepts used by emergency operations centers (EOCs). (2) Compare HIMS to the standard hospital incident command system (HICS) model. DESIGN: A quasi-experimental study was performed. Two identical tabletop incident scenarios were presented, one utilizing HICS and one using HIMS. Participants completed postexercise surveys for each tabletop. Surveys contained both knowledge and satisfaction questions...
April 2016: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28090666/quantitative-ultrashort-echo-time-imaging-for-assessment-of-massive-iron-overload-at-1-5-and-3-tesla
#3
Axel J Krafft, Ralf B Loeffler, Ruitian Song, Aaryani Tipirneni-Sajja, M Beth McCarville, Matthew D Robson, Jane S Hankins, Claudia M Hillenbrand
PURPOSE: Hepatic iron content (HIC) quantification via transverse relaxation rate (R2*)-MRI using multi-gradient echo (mGRE) imaging is compromised toward high HIC or at higher fields due to the rapid signal decay. Our study aims at presenting an optimized 2D ultrashort echo time (UTE) sequence for R2* quantification to overcome these limitations. METHODS: Two-dimensional UTE imaging was realized via half-pulse excitation and radial center-out sampling. The sequence includes chemically selective saturation pulses to reduce streaking artifacts from subcutaneous fat, and spatial saturation (sSAT) bands to suppress out-of-slice signals...
January 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28069446/rich2-is-implicated-in-viraemic-control-of-hiv-1-in-black-south-african-individuals
#4
Maria Paximadis, Refilwe N Ngqobe, Richard E Chaisson, Neil A Martinson, Caroline T Tiemessen
An intronic single nucleotide polymorphism (SNP) in RICH2 (rs2072255; 255(i)), in complete linkage disequilibrium (LD) with an exonic SNP (rs2072254; 254(e)), has been identified in a genome wide association study to be associated with progression to AIDS in Caucasian individuals. RICH2 links tetherin to the cortical actin network and the RICH2/tetherin interaction has been shown to be important for the downstream activation of NF-κβ and the consequential promotion of proinflammatory responses. We investigated the role of these two SNPs in natural control of HIV-1 in black South Africans including healthy controls (HCs; N=102) and antiretroviral-naive HIV-1-infected controllers (HICs; N=52) and progressors (N=74)...
January 6, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28056762/hic-bench-comprehensive-and-reproducible-hi-c-data-analysis-designed-for-parameter-exploration-and-benchmarking
#5
Charalampos Lazaris, Stephen Kelly, Panagiotis Ntziachristos, Iannis Aifantis, Aristotelis Tsirigos
BACKGROUND: Chromatin conformation capture techniques have evolved rapidly over the last few years and have provided new insights into genome organization at an unprecedented resolution. Analysis of Hi-C data is complex and computationally intensive involving multiple tasks and requiring robust quality assessment. This has led to the development of several tools and methods for processing Hi-C data. However, most of the existing tools do not cover all aspects of the analysis and only offer few quality assessment options...
January 5, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28017562/optimization-of-non-linear-gradient-in-hydrophobic-interaction-chromatography-for-the-analytical-characterization-of-antibody-drug-conjugates
#6
Balázs Bobály, Giuseppe Marco Randazzo, Serge Rudaz, Davy Guillarme, Szabolcs Fekete
The goal of this work was to evaluate the potential of non-linear gradients in hydrophobic interaction chromatography (HIC), to improve the separation between the different homologous species (drug-to-antibody, DAR) of commercial antibody-drug conjugates (ADC). The selectivities between Brentuximab Vedotin species were measured using three different gradient profiles, namely linear, power function based and logarithmic ones. The logarithmic gradient provides the most equidistant retention distribution for the DAR species and offers the best overall separation of cysteine linked ADC in HIC...
December 16, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28017431/who-consultation-on-group-b-streptococcus-vaccine-development-report-from-a-meeting-held-on-27-28-april-2016
#7
Miwako Kobayashi, Stephanie J Schrag, Mark R Alderson, Shabir A Madhi, Carol J Baker, Ajoke Sobanjo-Ter Meulen, David C Kaslow, Peter G Smith, Vasee S Moorthy, Johan Vekemans
Globally, group B Streptococcus (GBS) remains a leading cause of sepsis and meningitis in infants in the first 90days of life. Intrapartum antibiotic prophylaxis (IAP) for women at increased risk of transmitting GBS to their newborns has been effective in reducing part, but not all, of the GBS disease burden in many high income countries (HICs). In low- and middle-income countries (LMICs), IAP use is low. Immunization of pregnant women with a GBS vaccine represents an alternative strategy to protecting newborns and young infants, through transplacental antibody transfer and potentially by reducing new vaginal colonization...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/28004030/clinical-trials-in-low-and-middle-income-countries-successes-and-challenges
#8
REVIEW
Surbhi Grover, Melody Xu, Anuja Jhingran, Umesh Mahantshetty, Linus Chuang, William Small, David Gaffney
Gynecologic malignancies affect women in low and middle-income countries (LMICs) at equal or higher rates compared to high income countries (HICs), yet practice guidelines based on clinical trials performed in HICs do not routinely account for resource disparities between these regions. There is a need and growing interest for executing clinical trials in LMICs. This has led to the creation of multinational cooperative groups and the initiation of several ongoing clinical trials in Mexico, China, and Korea...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27999278/exploration-of-pedestrian-head-injuries-collision-parameter-relationships-through-a-combination-of-retrospective-analysis-and-finite-element-method
#9
Wenjun Liu, Sen Su, Jinlong Qiu, Yongyong Zhang, Zhiyong Yin
There are a very limited number of reports concerning the relationship between pedestrian head injuries and collision parameters through a combination of statistical analysis methods and finite element method (FEM). This study aims to explore the characteristics of pedestrian head injuries in car-pedestrian collisions at different parameters by using the two means above. A retrospective analysis of pedestrian head injuries was performed based on detailed investigation data of 61 car-pedestrian collision cases...
December 16, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27964768/evaluation-of-hospitals-disaster-preparedness-plans-in-the-holy-city-of-makkah-mecca-a-cross-sectional-observation-study
#10
Ali S Al-Shareef, Loui K Alsulimani, Hattan M Bojan, Taha M Masri, Jennifer O Grimes, Michael S Molloy, Gregory R Ciottone
BACKGROUND: Makkah (Mecca) is a holy city located in the western region of the Kingdom of Saudi Arabia. Each year, millions of pilgrims visit Makkah. These numbers impact both routine health care delivery and disaster response. This study aimed to evaluate hospitals' disaster plans in the city of Makkah. METHODS: Study investigators administered a questionnaire survey to 17 hospitals in the city of Makkah. Data on hospital characteristics and three key domains of disaster plans (general evaluation of disaster planning, structural feasibility of the hospitals, and health care worker knowledge and training) were collated and analyzed...
December 14, 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/27956119/long-term-effects-of-repeated-maternal-separation-and-ethanol-intake-on-hpa-axis-responsiveness-in-adult-rats
#11
María Mercedes Odeon, Laura Yamauchi, Mauricio Grosman, Gabriela Beatriz Acosta
It has been shown that early life manipulations produce behavioral, neural, and hormonal effects. The long term consequences of repeated maternal separation (RMS) plus cold stress and ethanol intake were evaluated during adolescence and adult rats on hypothalamic-pituitary-adrenal (HPA) axis in male adult Wistar rats. RMS+ cold stress was applied from postnatal day (PD) 2 in which the pups were separated from their mothers and exposed to cold stress (4°C) 1h per day for 20 days; controls remained with their mothers...
December 9, 2016: Brain Research
https://www.readbyqxmd.com/read/27943241/qsar-models-for-prediction-of-chromatographic-behavior-of-homologous-fab-variants
#12
Julie R Robinson, Hanne Sophie Karkov, James A Woo, Berit Olsen Krogh, Steven M Cramer
While quantitative structure activity relationship (QSAR) models have been employed successfully for the prediction of small model protein chromatographic behavior, there have been no reports to date on the use of this methodology for larger, more complex proteins. Recently our group generated focused libraries of antibody Fab fragment variants with different combinations of surface hydrophobicities and electrostatic potentials, and demonstrated that the unique selectivities of multimodal resins can be exploited to separate these Fab variants...
December 12, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27941981/-a-more-equitable-society-the-politics-of-global-fairness-in-paralympic-sport
#13
Leslie Swartz, Jason Bantjes, Divan Rall, Suzanne Ferreira, Cheri Blauwet, Wayne Derman
The Paralympic Movement explicitly sets out to create a more equitable society and promote participation for all and fairness in disability sport. This is primarily achieved through the use of a range of interventions with less attention given to how economic factors may hinder access and achievement in Paralympic sport. We investigated how country-level economic variables influence the level of participation and achievement in the 2015 International Paralympic Committee (IPC) Athletics Championships held in Doha...
2016: PloS One
https://www.readbyqxmd.com/read/27923102/pain-treatment-continues-to-be-inaccessible-for-many-patients-around-the-globe-second-phase-of-opioid-price-watch-a-cross-sectional-study-to-monitor-the-prices-of-opioids
#14
Tania Pastrana, Roberto Wenk, Lukas Radbruch, Ebtesam Ahmed, Liliana De Lima
BACKGROUND: Strong opioids are a cornerstone of pain treatment, of which morphine is considered an essential analgesic by the World Health Organization. Access to opioids is limited, due to restrictive laws, limited education, and high prices. This is the second phase of a global project to monitor and report the dispensing price of opioids with the specific aim to expand and increase the information and allow further analysis of the challenges in their availability and affordability...
December 6, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27921118/can-different-occlusal-positions-instantaneously-impact-spine-and-body-posture-a-pilot-study-using-rasterstereography-for-a-three-dimensional-evaluation
#15
Karoline März, Werner Adler, Ragai-Edward Matta, Linda Wolf, Manfred Wichmann, Bastian Bergauer
PURPOSE: Orthodontists influence dental occlusion directly. To suggest any link between dental occlusion and body posture is highly contentious, as evidenced by the literature. Rasterstereography, an optical technique that enables three-dimensional (3D) body measurements to be collected, has not yet been used to impartially examine whether different occlusal positions could instantaneously alter spine and body posture. We therefore set out to use this technique to nonsubjectively evaluate this question under static conditions...
December 5, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27914247/antenatal-depressive-symptoms-among-pregnant-women-evidence-from-a-southern-brazilian-population-based-cohort-study
#16
Carolina de Vargas Nunes Coll, Mariângela Freitas da Silveira, Diego Garcia Bassani, Elena Netsi, Fernando César Wehrmeister, Fernando César Barros, Alan Stein
BACKGROUND: Antenatal depression (AD) is a major public health issue but evidence regarding its prevalence and associated factors in low and middle-income countries (LMICs) is limited. The aim of the study was to estimate the prevalence and identify risk factors for AD among Brazilian pregnant women. METHODS: All women living in the urban area of the city of Pelotas, Southern Brazil, with confirmed pregnancy and estimated delivery date in the year 2015, were invited to take part...
February 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27913348/automatic-refinement-strategies-for-manual-initialization-of-object-trackers
#17
Hao Zhu, Fatih Porikli
Tracking objects across multiple frames is a wellinvestigated problem in computer vision. The majority of the existing algorithms assume an accurate initialization is readily available. However, in many real-life settings, in particular for applications where the video is streaming in real-time, the initialization has to be provided by a human operator. This limitation raises an inevitable uncertainty issue. Here, we first collect a large and new dataset of inputs that consists of more than 20K human initialization clicks, called as HIC, by several subjects under three practical user interface scenarios for the popular TB50 tracking benchmark...
December 1, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27912158/direct-detection-of-phenylephrine-3-o-sulfate-in-ls180-human-intestinal-cells-using-a-novel-hydrophilic-interaction-liquid-chromatography-hilic-assay
#18
Heta N Shah, Matthew T Halquist, Phillip M Gerk
The efficacy of phenylephrine (PE) is controversial due to its extensive pre-systemic metabolism through sulfation to form phenylephrine-3-O-sulfate (PES). Hence quantitation of PES is important in order to study the metabolism of PE. There are no published methods available for direction detection of PES. We have developed and validated a hydrophilic interaction liquid chromatography (HILIC) method for the direct detection of PES and simultaneous detection of PE to study the enzyme kinetics and metabolism of PE to enable approaches to reduce the presystemic metabolism of PE...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27895904/poor-adherence-to-guidelines-for-preventing-central-line-associated-bloodstream-infections-clabsi-results-of-a-worldwide-survey
#19
Cristina Valencia, Naïma Hammami, Antonella Agodi, Alain Lepape, Eduardo Palencia Herrejon, Stijn Blot, Jean-Louis Vincent, Marie-Laurence Lambert
BACKGROUND: Central line-associated bloodstream infections (CLABSI) are a cause of increased morbidity and mortality, and are largely preventable. We documented attitudes and practices in intensive care units (ICUs) in 2015 in order to assess compliance with CLABSI prevention guidelines. METHODS: Between June and October 2015, an online questionnaire was made available to medical doctors and nurses working in ICUs worldwide. We investigated practices related to central line (CL) insertion, maintenance and measurement of CLABSI-related data following the SHEA guidelines as a standard...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27895806/genome-wide-epigenomic-profiling-for-biomarker-discovery
#20
REVIEW
René A M Dirks, Hendrik G Stunnenberg, Hendrik Marks
A myriad of diseases is caused or characterized by alteration of epigenetic patterns, including changes in DNA methylation, post-translational histone modifications, or chromatin structure. These changes of the epigenome represent a highly interesting layer of information for disease stratification and for personalized medicine. Traditionally, epigenomic profiling required large amounts of cells, which are rarely available with clinical samples. Also, the cellular heterogeneity complicates analysis when profiling clinical samples for unbiased genome-wide biomarker discovery...
2016: Clinical Epigenetics
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