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https://www.readbyqxmd.com/read/28209711/serotype-3-pneumococci-sequester-platelet-derived-human-thrombospondin-1-via-the-adhesin-and-immune-evasion-protein-hic
#1
Ulrike Binsker, Thomas P Kohler, Krystin Krauel, Sylvia Kohler, Johanna Habermeyer, Hansjörg Schwertz, Sven Hammerschmidt
Streptococcus pneumoniae serotype 3 strains emerge frequently within clinical isolates of invasive diseases. Bacterial invasion into deeper tissues is associated with colonization and immune evasion mechanisms. Thus, pneumococci express a versatile repertoire of surface proteins sequestering and interacting specifically with components of the human extracellular matrix and serum. Hic, a PspC-like pneumococcal surface protein possesses vitronectin and Factor H binding activity. Here, we show that heterologously expressed Hic domains interact, similar to the classical PspC molecule, with human matricellular thrombospondin-1 (hTSP-1)...
February 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28186011/mapping-local-codes-to-read-codes
#2
Wilfred Bonney, James Galloway, Christopher Hall, Mikhail Ghattas, Leandro Tramma, Thomas Nind, Louise Donnelly, Emily Jefferson, Alexander Doney
: Background & Objectives: Legacy laboratory test codes make it difficult to use clinical datasets for meaningful translational research, where populations are followed for disease risk and outcomes over many years. The Health Informatics Centre (HIC) at the University of Dundee hosts continuous biochemistry data from the clinical laboratories in Tayside and Fife dating back as far as 1987. However, the HIC-managed biochemistry dataset is coupled with incoherent sample types and unstandardised legacy local test codes, which increases the complexity of using the dataset for reasonable population health outcomes...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28174236/merkel-cell-carcinomas-arising-in-autoimmune-disease-affected-patients-treated-with-biological-drugs-including-tnf
#3
John C Rotondo, Ilaria Bononi, Andrea Puozzo, Marcello Govoni, Valentina Foschi, Giovanni Lanza, Roberta Gafà, Antoine Touzè, Pauline Gaboriaud, Rita Selvatici, Fernanda Martini, Mauro Tognon
PURPOSE: The purpose of this investigation was to characterize Merkel cell carcinomas (MCC) arising in patients affected by auto-immune diseases, treated with biologic drugs. EXPERIMENTAL DESIGN: Serum samples from MCC patients were analyzed for the presence and titer of antibodies against antigens of the oncogenic Merkel cell polyomavirus (MCPyV). IgG antibodies against the viral oncoproteins Large T (LT) and small t (ST) antigens and the viral capsid protein 1 were analyzed by indirect E...
February 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28168838/importance-of-including-stillbirth-in-measures-of-preterm-birth
#4
Robert L Goldenberg, Elizabeth M McClure
Stillbirth, one of the most common adverse pregnancy outcomes world-wide, occurs far more commonly in low-income countries (LIC) than elsewhere with rates 10 to 20 fold greater than rates in high-income countries (HIC). Preterm birth (PTB) substantially increases risk of neonatal mortality and long-term developmental handicap. PTB and stillbirth rates, if reported at all for LIC, are rarely considered together (Aminu et al; BJOG 2014:121:141-53). This article is protected by copyright. All rights reserved.
February 6, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28133982/the-prevention-of-violence-in-childhood-through-parenting-programmes-a-global-review
#5
Charlene Coore Desai, Jody-Ann Reece, Sydonnie Shakespeare-Pellington
Child maltreatment is a global problem affecting both high income (HICs) and low and middle income countries (LMICs). However research has shown that children who live in the world's poorest countries and communities are more likely to suffer from abuse and neglect. There is some evidence that parenting interventions can assist in the prevention of child maltreatment, but most of this research has been conducted in HICs. The main aim of this review was to examine the evidence from previous systematic reviews on the role of parenting programmes in the prevention of violence against children in both HICs and LMICs...
January 29, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28133980/the-impact-of-polyvictimisation-on-children-in-lmics-the-case-of-jamaica
#6
Maureen Samms-Vaughan, Michael Lambert
Children who experience polyvictimization in high-income countries (HICs) are at higher risk for mental health-related trauma symptoms. There is limited information on the impact of polyvictimisation on children with high levels of exposure, as occurs in some low- and middle-income countries (LMICs). This study investigates the impact of poyvictimization on Jamaican children's intellectual functioning, achievement, and disruptive behaviors. Data from a geographical subgroup (n = 1171) of a 1986 population based birth cohort study were utilised...
January 29, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28126460/laboratory-based-and-office-based-risk-scores-and-charts-to-predict-10-year-risk-of-cardiovascular-disease-in-182-countries-a-pooled-analysis-of-prospective-cohorts-and-health-surveys
#7
Peter Ueda, Mark Woodward, Yuan Lu, Kaveh Hajifathalian, Rihab Al-Wotayan, Carlos A Aguilar-Salinas, Alireza Ahmadvand, Fereidoun Azizi, James Bentham, Renata Cifkova, Mariachiara Di Cesare, Louise Eriksen, Farshad Farzadfar, Trevor S Ferguson, Nayu Ikeda, Davood Khalili, Young-Ho Khang, Vera Lanska, Luz León-Muñoz, Dianna J Magliano, Paula Margozzini, Kelias P Msyamboza, Gerald Mutungi, Kyungwon Oh, Sophal Oum, Fernando Rodríguez-Artalejo, Rosalba Rojas-Martinez, Gonzalo Valdivia, Rainford Wilks, Jonathan E Shaw, Gretchen A Stevens, Janne S Tolstrup, Bin Zhou, Joshua A Salomon, Majid Ezzati, Goodarz Danaei
BACKGROUND: Worldwide implementation of risk-based cardiovascular disease (CVD) prevention requires risk prediction tools that are contemporarily recalibrated for the target country and can be used where laboratory measurements are unavailable. We present two cardiovascular risk scores, with and without laboratory-based measurements, and the corresponding risk charts for 182 countries to predict 10-year risk of fatal and non-fatal CVD in adults aged 40-74 years. METHODS: Based on our previous laboratory-based prediction model (Globorisk), we used data from eight prospective studies to estimate coefficients of the risk equations using proportional hazard regressions...
January 23, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28122623/criteria-to-assess-potential-reverse-innovations-opportunities-for-shared-learning-between-high-and-low-income-countries
#8
Onil Bhattacharyya, Diane Wu, Kathryn Mossman, Leigh Hayden, Pavan Gill, Yu-Ling Cheng, Abdallah Daar, Dilip Soman, Christina Synowiec, Andrea Taylor, Joseph Wong, Max von Zedtwitz, Stanley Zlotkin, William Mitchell, Anita McGahan
BACKGROUND: Low- and middle-income countries (LMICs) are developing novel approaches to healthcare that may be relevant to high-income countries (HICs). These include products, services, organizational processes, or policies that improve access, cost, or efficiency of healthcare. However, given the challenge of replication, it is difficult to identify innovations that could be successfully adapted to high-income settings. We present a set of criteria for evaluating the potential impact of LMIC innovations in HIC settings...
January 25, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28102701/the-effect-of-pre-crash-velocity-reduction-on-occupant-response-using-a-human-body-finite-element-model
#9
B Guleyupoglu, J Schap, K D Kusano, F S Gayzik
OBJECTIVE: The objective of this study is to use a validated finite element model of the human body and a certified model of an ATD to evaluate the effect of simulated pre-crash braking on driver kinematics, restraint loads, body loads and computed injury criteria in four commonly-injured body regions. METHODS: The Global Human Body Models Consortium (GHBMC) 50th percentile male occupant (M50-O) and the Humanetics Hybrid-III 50(th) percentile models were gravity settled in the driver position of a generic interior equipped with an advanced three point belt and driver airbag...
January 19, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28102533/hospital-incident-command-first-responders-or-receiving-centers
#10
Brian Fletcher, Amanda Knight, Brandy Pockrus, Matthew J Wain, Kathy Lehman-Huskamp
OBJECTIVES: (1) Propose a conceptual model of an alternative hospital incident management system (HIMS) that integrates concepts used by emergency operations centers (EOCs). (2) Compare HIMS to the standard hospital incident command system (HICS) model. DESIGN: A quasi-experimental study was performed. Two identical tabletop incident scenarios were presented, one utilizing HICS and one using HIMS. Participants completed postexercise surveys for each tabletop. Surveys contained both knowledge and satisfaction questions...
April 2016: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28090666/quantitative-ultrashort-echo-time-imaging-for-assessment-of-massive-iron-overload-at-1-5-and-3-tesla
#11
Axel J Krafft, Ralf B Loeffler, Ruitian Song, Aaryani Tipirneni-Sajja, M Beth McCarville, Matthew D Robson, Jane S Hankins, Claudia M Hillenbrand
PURPOSE: Hepatic iron content (HIC) quantification via transverse relaxation rate (R2*)-MRI using multi-gradient echo (mGRE) imaging is compromised toward high HIC or at higher fields due to the rapid signal decay. Our study aims at presenting an optimized 2D ultrashort echo time (UTE) sequence for R2* quantification to overcome these limitations. METHODS: Two-dimensional UTE imaging was realized via half-pulse excitation and radial center-out sampling. The sequence includes chemically selective saturation pulses to reduce streaking artifacts from subcutaneous fat, and spatial saturation (sSAT) bands to suppress out-of-slice signals...
January 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28069446/rich2-is-implicated-in-viraemic-control-of-hiv-1-in-black-south-african-individuals
#12
Maria Paximadis, Refilwe N Ngqobe, Richard E Chaisson, Neil A Martinson, Caroline T Tiemessen
An intronic single nucleotide polymorphism (SNP) in RICH2 (rs2072255; 255(i)), in complete linkage disequilibrium (LD) with an exonic SNP (rs2072254; 254(e)), has been identified in a genome wide association study to be associated with progression to AIDS in Caucasian individuals. RICH2 links tetherin to the cortical actin network and the RICH2/tetherin interaction has been shown to be important for the downstream activation of NF-κβ and the consequential promotion of proinflammatory responses. We investigated the role of these two SNPs in natural control of HIV-1 in black South Africans including healthy controls (HCs; N=102) and antiretroviral-naive HIV-1-infected controllers (HICs; N=52) and progressors (N=74)...
January 6, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28056762/hic-bench-comprehensive-and-reproducible-hi-c-data-analysis-designed-for-parameter-exploration-and-benchmarking
#13
Charalampos Lazaris, Stephen Kelly, Panagiotis Ntziachristos, Iannis Aifantis, Aristotelis Tsirigos
BACKGROUND: Chromatin conformation capture techniques have evolved rapidly over the last few years and have provided new insights into genome organization at an unprecedented resolution. Analysis of Hi-C data is complex and computationally intensive involving multiple tasks and requiring robust quality assessment. This has led to the development of several tools and methods for processing Hi-C data. However, most of the existing tools do not cover all aspects of the analysis and only offer few quality assessment options...
January 5, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28017562/optimization-of-non-linear-gradient-in-hydrophobic-interaction-chromatography-for-the-analytical-characterization-of-antibody-drug-conjugates
#14
Balázs Bobály, Giuseppe Marco Randazzo, Serge Rudaz, Davy Guillarme, Szabolcs Fekete
The goal of this work was to evaluate the potential of non-linear gradients in hydrophobic interaction chromatography (HIC), to improve the separation between the different homologous species (drug-to-antibody, DAR) of commercial antibody-drug conjugates (ADC). The selectivities between Brentuximab Vedotin species were measured using three different gradient profiles, namely linear, power function based and logarithmic ones. The logarithmic gradient provides the most equidistant retention distribution for the DAR species and offers the best overall separation of cysteine linked ADC in HIC...
January 20, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28017431/who-consultation-on-group-b-streptococcus-vaccine-development-report-from-a-meeting-held-on-27-28-april-2016
#15
Miwako Kobayashi, Stephanie J Schrag, Mark R Alderson, Shabir A Madhi, Carol J Baker, Ajoke Sobanjo-Ter Meulen, David C Kaslow, Peter G Smith, Vasee S Moorthy, Johan Vekemans
Globally, group B Streptococcus (GBS) remains a leading cause of sepsis and meningitis in infants in the first 90days of life. Intrapartum antibiotic prophylaxis (IAP) for women at increased risk of transmitting GBS to their newborns has been effective in reducing part, but not all, of the GBS disease burden in many high income countries (HICs). In low- and middle-income countries (LMICs), IAP use is low. Immunization of pregnant women with a GBS vaccine represents an alternative strategy to protecting newborns and young infants, through transplacental antibody transfer and potentially by reducing new vaginal colonization...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/28004030/clinical-trials-in-low-and-middle-income-countries-successes-and-challenges
#16
REVIEW
Surbhi Grover, Melody Xu, Anuja Jhingran, Umesh Mahantshetty, Linus Chuang, William Small, David Gaffney
Gynecologic malignancies affect women in low and middle-income countries (LMICs) at equal or higher rates compared to high income countries (HICs), yet practice guidelines based on clinical trials performed in HICs do not routinely account for resource disparities between these regions. There is a need and growing interest for executing clinical trials in LMICs. This has led to the creation of multinational cooperative groups and the initiation of several ongoing clinical trials in Mexico, China, and Korea...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27999278/exploration-of-pedestrian-head-injuries-collision-parameter-relationships-through-a-combination-of-retrospective-analysis-and-finite-element-method
#17
Wenjun Liu, Sen Su, Jinlong Qiu, Yongyong Zhang, Zhiyong Yin
There are a very limited number of reports concerning the relationship between pedestrian head injuries and collision parameters through a combination of statistical analysis methods and finite element method (FEM). This study aims to explore the characteristics of pedestrian head injuries in car-pedestrian collisions at different parameters by using the two means above. A retrospective analysis of pedestrian head injuries was performed based on detailed investigation data of 61 car-pedestrian collision cases...
December 16, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27964768/evaluation-of-hospitals-disaster-preparedness-plans-in-the-holy-city-of-makkah-mecca-a-cross-sectional-observation-study
#18
Ali S Al-Shareef, Loui K Alsulimani, Hattan M Bojan, Taha M Masri, Jennifer O Grimes, Michael S Molloy, Gregory R Ciottone
BACKGROUND: Makkah (Mecca) is a holy city located in the western region of the Kingdom of Saudi Arabia. Each year, millions of pilgrims visit Makkah. These numbers impact both routine health care delivery and disaster response. This study aimed to evaluate hospitals' disaster plans in the city of Makkah. METHODS: Study investigators administered a questionnaire survey to 17 hospitals in the city of Makkah. Data on hospital characteristics and three key domains of disaster plans (general evaluation of disaster planning, structural feasibility of the hospitals, and health care worker knowledge and training) were collated and analyzed...
February 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/27956119/long-term-effects-of-repeated-maternal-separation-and-ethanol-intake-on-hpa-axis-responsiveness-in-adult-rats
#19
María Mercedes Odeon, Laura Yamauchi, Mauricio Grosman, Gabriela Beatriz Acosta
It has been shown that early life manipulations produce behavioral, neural, and hormonal effects. The long term consequences of repeated maternal separation (RMS) plus cold stress and ethanol intake were evaluated during adolescence and adult rats on hypothalamic-pituitary-adrenal (HPA) axis in male adult Wistar rats. RMS+ cold stress was applied from postnatal day (PD) 2 in which the pups were separated from their mothers and exposed to cold stress (4°C) 1h per day for 20 days; controls remained with their mothers...
December 9, 2016: Brain Research
https://www.readbyqxmd.com/read/27943241/qsar-models-for-prediction-of-chromatographic-behavior-of-homologous-fab-variants
#20
Julie R Robinson, Hanne Sophie Karkov, James A Woo, Berit Olsen Krogh, Steven M Cramer
While quantitative structure activity relationship (QSAR) models have been employed successfully for the prediction of small model protein chromatographic behavior, there have been no reports to date on the use of this methodology for larger, more complex proteins. Recently our group generated focused libraries of antibody Fab fragment variants with different combinations of surface hydrophobicities and electrostatic potentials, and demonstrated that the unique selectivities of multimodal resins can be exploited to separate these Fab variants...
December 12, 2016: Biotechnology and Bioengineering
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