Yu Lin, Jing Li, Yiren Gu, Long Jin, Jingyi Bai, Jiaman Zhang, Yujie Wang, Pengliang Liu, Keren Long, Mengnan He, Diyan Li, Can Liu, Ziyin Han, Yu Zhang, Xiaokai Li, Bo Zeng, Lu Lu, Fanli Kong, Ying Sun, Yongliang Fan, Xun Wang, Tao Wang, An'an Jiang, Jideng Ma, Linyuan Shen, Li Zhu, Yanzhi Jiang, Guoqing Tang, Xiaolan Fan, Qingyou Liu, Hua Li, Jinyong Wang, Li Chen, Liangpeng Ge, Xuewei Li, Qianzi Tang, Mingzhou Li
In diploid mammals, allele-specific three-dimensional (3D) genome architecture may lead to imbalanced gene expression. Through ultradeep in situ Hi-C sequencing of three representative somatic tissues (liver, skeletal muscle, and brain) from hybrid pigs generated by reciprocal crosses of phenotypically and physiologically divergent Berkshire and Tibetan pigs, we uncover extensive chromatin reorganization between homologous chromosomes across multiple scales. Haplotype-based interrogation of multi-omic data revealed the tissue dependence of 3D chromatin conformation, suggesting that parent-of-origin-specific conformation may drive gene imprinting...
March 13, 2024: Genome Research