keyword
MENU ▼
Read by QxMD icon Read
search

Lumbar disc herniation

keyword
https://www.readbyqxmd.com/read/28810608/mechanism-of-microrna-21-regulating-il-6-inflammatory-response-and-cell-autophagy-in-intervertebral-disc-degeneration
#1
Hao Lin, Wenzhi Zhang, Tao Zhou, Wansu Li, Ziao Chen, Chaochao Ji, Chao Zhang, Fang He
This study investigated the mechanism of microRNA-21 in regulating IL-6 inflammatory response and cell autophagy in intervertebral disc degeneration. A total of 10 patients with lumbar disc herniation accompanied by nerve root pain (observation group) and 10 patients with lumbar burst fractures (control group) were selected. The nucleus pulposus tissues of the lesion were obtained during operation for cell culture. Real-time quantitative polymerase chain reaction (PCR) was used to detect the expression of microRNA-21...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810568/mechanism-of-microrna-146a-mediated-il-6-stat3-signaling-in-lumbar-intervertebral-disc-degeneration
#2
Tao Zhou, Hao Lin, Ziao Cheng, Chaochao Ji, Chao Zhang, Jiwei Tian
The aim of the study was to investigate the mechanism of microRNA (miR)-146a-mediated activation of interleukin-6/signal transducer and activator of transcription 3 (IL-6/STAT3) in lumbar intervertebral disc degeneration. To obtain intervertebral tissue, we recruited 5 patients with lumbar intervertebral disc herniation (experimental group) and 5 patients with lumbar burst fracture (control group). Nucleus pulposus tissue was extracted by surgery and cultured. miR-146a empty vector, mimic, and inhibitor were transfected into the two groups of cells for 24 h and the levels of IL-6, type II collagen (Col II), aggrecan, STAT3, matrix metalloproteinase (MMP)-3, and a disintegrin and metalloproteinase with thrombospondin type I motifs (ADAMTS) were detected...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808602/high-lumbar-noninstrumented-fusion-rates-using-lamina-autograft-and-nanoss-bone-marrow-aspirate
#3
Nancy E Epstein
BACKGROUND: Patients with marked osteoporosis and/or obesity/morbid obesity and severe multilevel lumbar stenosis and other pathology often undergo multilevel laminectomies with non instrumented posterolateral fusions (PLF). The other pathology may include combinations of degenerative spondylolisthesis/lysis, foraminal/far lateral discs, and/or synovial cysts requiring more extensive facet resections. Presently, spine surgeons often use bone graft expanders to supplement the lamina autograft harvested in the course of laminectomy/decompressions for the PLF mass...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28796755/the-effect-of-lumbar-disc-herniation-on-musculoskeletal-loadings-in-the-spinal-region-during-level-walking-and-stair-climbing
#4
Shengzheng Kuai, Zhenhua Liao, Wenyu Zhou, Xinyu Guan, Run Ji, Rui Zhang, Daiqi Guo, Weiqiang Liu
BACKGROUND People with low back pain (LBP) alter their motion patterns during level walking and stair climbing due to pain or fear. However, the alternations of load sharing during the two activities are largely unknown. The objective of this study was to investigate the effect of LBP caused by lumbar disc herniation (LDH) on the muscle activities of 17 main trunk muscle groups and the intradiscal forces acting on the five lumbar discs. MATERIAL AND METHODS Twenty-six healthy adults and seven LDH patients were recruited to perform level walking and stair climbing in the Gait Analysis Laboratory...
August 10, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28796647/cauda-equina-syndrome-due-to-vigorous-back-massage-with-spinal-manipulation-in-a-patient-with-pre-existing-lumbar-disc-herniation-a-case-report-and-literature-review
#5
Si-Dong Yang, Qian Chen, Wen-Yuan Ding
Cauda equina syndrome (CES) resulting from acute lumbar disc herniation due to spinal massage is extremely rare. We present a case of CES caused by the acute worsening of a lumbar disc herniation after a vigorous back massage that included spinal manipulation. After vigorous back massage with spinal manipulation performed by a massage therapist, a 38-yr-old male patient experienced CES with severe numbness in both lower limbs, inability to walk due to weakness of bilateral lower limbs, and incontinence of urine and feces...
August 7, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28791480/a-more-realistic-disc-herniation-model-incorporating-compression-flexion-and-facet-constrained-shear-a-mechanical-and-microstructural-analysis-part-ii-high-rate-or-surprise-loading
#6
Zhi Shan, Kelly R Wade, Meredith L Schollum, Peter A Robertson, Ashvin Thambyah, Neil D Broom
PURPOSE: Part I of this study explored mechanisms of disc failure in a complex posture incorporating physiological amounts of flexion and shear at a loading rate considerably lower than likely to occur in a typical in vivo manual handling situation. Given the strain-rate-dependent mechanical properties of the heavily hydrated disc, loading rate will likely influence the mechanisms of disc failure. Part II investigates the mechanisms of failure in healthy discs subjected to surprise-rate compression while held in the same complex posture...
August 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28781912/nursing-review-section-of-surgical-neurology-international-part-1-lumbar-disc-disease
#7
Nancy E Epstein, Renee D Hollingsworth
BACKGROUND: Patients with lumbar disc disease may present with low back pain, pain that radiates down into the lower extremity (radiculopathy), and leg pain that increases with ambulation (neurogenic claudication). Patients may first undergo diagnostic studies [(magnetic resonance imaging (MRI) and computed tomographic (CT) examinations] to determine whether there is any significant nerve root or thecal sac compression. METHODS: Increasingly, patients with low back pain with/without radiculopathy are being screened by nurses rather than by neurologists or neurosurgeons/orthopedists...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28779960/efficacy-and-safety-of-etanercept-in-the-treatment-of-sciatica-a-systematic-review-and-meta-analysis
#8
REVIEW
Shangfei Jing, Chenyuan Yang, Xiaofei Zhang, Shuzheng Wen, Yuankui Li
Etanercept might be promising to alleviate sciatica caused by lumbar disc herniation and spinal stenosis. However, the results remained controversial. We conducted a systematic review and meta-analysis to evaluate the efficacy of etanercept in patients with sciatica. PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) and Controlled clinical trials (CCT) assessing the efficacy of etanercept on sciatica caused by lumbar disc herniation and spinal stenosis were included...
August 2, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28776544/quantitative-evaluation-of-pain-with-pain-index-extracted-from-electroencephalogram
#9
Jian-Xiong An, Yong Wang, Doris K Cope, John P Williams
BACKGROUND: The current pain assessment methods are strongly subjective and easily affected by outside influences, and there is an urgent need to develop a reliable objective and quantitative pain-monitoring indicator. The aim of this study was to evaluate the feasibility of using Pain index (Pi) to assess pain symptoms in pain patients. METHODS: Subjects were enrolled from patients seeking treatment at Pain Medicine Center of China Medical University Aviation General Hospital from October 2015 to December 2016, such as postherpetic neuralgia, spinal cord injury, femoral head necrosis, lumbar disc herniation, trigeminal neuralgia, complex regional pain syndrome, perineal pain, phantom limb pain, etc...
August 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28775056/prospective-comparison-of-changes-in-lumbar-spine-mri-findings-over-time-between-individuals-with-acute-low-back-pain-and-controls-an-exploratory-study
#10
J Panagopoulos, J S Magnussen, J Hush, C G Maher, M Crites-Battie, J G Jarvik, T S Jensen, M J Hancock
BACKGROUND AND PURPOSE: The clinical importance of lumbar MR imaging findings is unclear. This study was an exploratory investigation of whether lumbar spine MR imaging findings change more commonly during a 12-week period in individuals with acute low back pain compared with pain-free controls. MATERIALS AND METHODS: Twenty individuals with recent-onset low back pain and 10 pain-free controls were recruited into an exploratory prospective cohort study. All participants had a lumbar spine MR imaging at baseline and repeat MR imaging scans at 1, 2, 6, and 12 weeks...
August 3, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28769985/long-term-course-to-lumbar-disc-resorption-patients-and-predictive-factors-associated-with-disc-resorption
#11
Jinho Lee, Joowon Kim, Joon-Shik Shin, Yoon Jae Lee, Me-Riong Kim, Seon-Yeong Jeong, Young-Jun Choi, Tae Kyung Yoon, Byung-Heon Moon, Su-Bin Yoo, Jungsoo Hong, In-Hyuk Ha
The long-term course to lumbar intervertebral disc herniation (LDH) patients receiving integrative Korean medicine treatment and predictive factors associated with disc resorption were investigated. LDH patients who received integrative Korean medicine treatment from February 2012 to December 2015 and were registered in the "longitudinal project for LDH on MRI" were included. Disc resorption amount was measured 3-dimensionally with disc degeneration and modic change levels on baseline and follow-up MRIs. Patient characteristics, Korean medicine use, pain, symptom recurrence, and satisfaction were assessed through medical records and phone surveys...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28767602/iatrogenic-rupture-of-the-left-main-bronchus-secondary-to-repeated-surgical-lobe-torsion-during-double-lumen-tube-placement-a-case-report
#12
Zong Ming Jiang, Chu Zhang, Zhong Hua Chen
RATIONALE: Bronchial rupture is a rare but potentially life-threatening complication during double-lumen endobronchial tube placement. The rupture of the left main bronchus resulting from repeated surgical torsion is uncommon. PATIENT CONCERNS: A 70-year-old man with a history of chronic obstructive pulmonary disease (COPD), intermediate emphysema, chronic bronchitis, hypertension, type 2 diabetes mellitus, and L3-L4 lumbar intervertebral disc herniation. Chest x-ray and computed tomography revealed a solitary pulmonary nodule in the left lower lobe...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28765022/recurrent-lumbar-disc-herniation-after-tubular-microdiscectomy-analysis-of-learning-curve-progression
#13
Victor E Staartjes, Marlies P de Wispelaere, Johan Miedema, Marc L Schröder
OBJECTIVE: Tubular microdiscectomy has become a staple technique among spine surgeons. Yet the associated learning curve, especially its later stages, has not been extensively studied. With studies reporting a higher rate of recurrent herniation using tubular microdiscectomy, surgeons' level of experience becomes of primary importance for the interpretation of such findings. We aimed to analyze possible improvements in the later stages of the learning curve, and to identify factors independently associated with recurrent herniation...
July 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28764746/percutaneous-endoscopic-lumbar-discectomy-minimally-invasive-technique-for-multiple-episodes-of-lumbar-disc-herniation
#14
Kyung-Chul Choi, Jin-Sung Kim, Dong Chan Lee, Choon-Keun Park
BACKGROUNDS: Although open lumbar discectomy is a gold standard surgical technique for lumbar disc herniation (LDH), surgery-induced tissue injury may actually become a source of postsurgical pain. Percutaneous endoscopic lumbar discectomy (PELD) is introduced as a minimal invasive spinal technique for LDH. The PELD has gained popularity and shown successful results. The authors report the clinical usefulness of the PELD technique in two patients with the serial multilevel LDHs. CASE PRESENTATIONS: A 32-year-old man suffered from radicular pain at the L5 dermatome due to the down migrated soft LDH at the L4-5 level...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28764694/predictors-of-haematocrit-in-lumbar-fusion-for-lumbar-disc-herniation-a-surgical-assessment
#15
Qingchun Cai, Sixiang Zeng, Liqiang Zhi, Junlong Wu, Wei Ma
BACKGROUND: Low haematocrit (Hct) is associated with a higher rate of post-operative complications, increased mortality, and additional medical costs following cardiac surgery. Predictors of post-operative Hct in lumbar fusion are unclear and may be beneficial in avoiding adverse surgical outcomes. METHODS: A total of 704 lumbar disc herniation patients (385 males, 319 females) who underwent primary lumbar fusion surgery were reviewed in this retrospective study...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28763411/patient-decision-aids-improve-decision-quality-and-patient-experience-and-reduce-surgical-rates-in-routine-orthopaedic-care-a-prospective-cohort-study
#16
Karen Sepucha, Steven J Atlas, Yuchiao Chang, Janet Dorrwachter, Andrew Freiberg, Mahima Mangla, Harry E Rubash, Leigh H Simmons, Thomas Cha
BACKGROUND: Patient decision aids are effective in randomized controlled trials, yet little is known about their impact in routine care. The purpose of this study was to examine whether decision aids increase shared decision-making when used in routine care. METHODS: A prospective study was designed to evaluate the impact of a quality improvement project to increase the use of decision aids for patients with hip or knee osteoarthritis, lumbar disc herniation, or lumbar spinal stenosis...
August 2, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28760027/clinical-and-radiological-outcomes-of-spinal-endoscopic-discectomy-assisted-oblique-lumbar-interbody-fusion-preliminary-results
#17
Dong Hwa Heo, Jin-Sung Kim
OBJECTIVE Direct neural decompression cannot be achieved by performing lateral lumbar interbody fusion (LLIF). To overcome the indirect decompressive effect of LLIF, additional endoscopic discectomy with oblique lumbar interbody fusion (OLIF) has been attempted. The purpose of this study was to assess the clinical and radiological outcomes of patients who underwent OLIF with additional endoscopic discectomy. METHODS Spinal endoscopic discectomy-assisted OLIF was attempted to remove herniated disc material. Only patients with a follow-up time that exceeded 12 months were enrolled...
August 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28757523/operative-techniques-of-percutaneous-endoscopic-mini-hemilaminectomy-using-a-uniportal-approach-in-dogs
#18
Hee-Sup Moon, Yong-Hyun Hwang, Hee-Chun Lee, Jae-Hoon Lee
The present study aimed to investigate the technical feasibility of percutaneous endoscopic mini-hemilaminectomy via a uniportal approach, and to evaluate the possibility of decompression and endoscopic examination of the thoracic and lumbar spinal canals in small dogs during such procedures. Fresh canine cadavers of mixed-breed dogs (n=7) were used in this study. Following injection of a barium and agarose mixture (BA-gel) to stimulate intervertebral disc herniation, percutaneous endoscopic mini-hemilaminectomy was performed using a lateral approach to the thoracic and lumbar vertebrae...
July 31, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28756300/obesity-and-spinal-epidural-lipomatosis-in-cauda-equina-syndrome
#19
Duncan Cushnie, Jennifer C Urquhart, Kevin R Gurr, Fawaz Siddiqi, Christopher S Bailey
BACKGROUND CONTEXT: Although lumbar disc herniations are common, only a small portion of these herniations lead to cauda equina syndrome (CES) which is an uncommon but debilitating disorder. Why some patients with herniation develop CES, when most do not, remains unknown. Pre-existing subclinical epidural lipomatosis may limit canal space such that an otherwise benign herniation causes CES. PURPOSE: This study determines whether patients with an acute disc herniation and CES have a greater body mass index (BMI) and greater quantity of epidural fat compared to control subjects with non-CES symptomatic lumbar herniated discs...
July 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28756222/role-of-lncrna-tug1-in-intervertebral-disc-degeneration-and-nucleus-pulposus-cells-via-regulating-wnt-%C3%AE-catenin-signaling-pathway
#20
Jiang Chen, Yu-Song Jia, Gen-Zhe Liu, Qi Sun, Fan Zhang, Sheng Ma, Yong-Jun Wang
OBJECTIVE: To investigate the role of TUG1 in intervertebral disc degeneration (IDD) and human nucleus pulposus cells (NPCs) via regulating Wnt/β-catenin pathway. METHODS: The study collected nucleus pulposus (NP) tissue samples from 30 patients with lumbar disc herniation (LDH) (Case group) and 18 patients with lumbar spine trauma (Control group). NPCs induced by TNF-α in vitro were divided into Blank, Vector, TUG1, TUG1-siRNA, XAV-939, TUG1 + XAV-939 groups...
July 26, 2017: Biochemical and Biophysical Research Communications
keyword
keyword
10474
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"