keyword
MENU ▼
Read by QxMD icon Read
search

Methionine supplement

keyword
https://www.readbyqxmd.com/read/28447340/marginal-deficiencies-of-dietary-arginine-and-methionine-could-suppress-growth-performance-and-immunological-responses-in-broiler-chickens
#1
R Jahanian, M Khalifeh-Gholi
The present study was conducted to investigate the effects of different levels of dietary arginine (Arg) and methionine (Met) on performance, immune responses, and carcass characteristics of broiler chickens. A total of 540 day-old Ross 308 broiler chicks were randomly assigned into the nine experimental diets, consisting five replicates of 12 birds each. Dietary treatments included three different levels (90%, 100%, and 110% of National Research Council [NRC] specifications) of either dietary Arg or Met, which were fed to the birds according to a 3 × 3 factorial arrangement of treatments during a 42 days feeding trial...
April 26, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28446631/combined-vitamin-b-12-and-balanced-protein-energy-supplementation-affect-homocysteine-remethylation-in-the-methionine-cycle-in-pregnant-south-indian-women-of-low-vitamin-b-12-status
#2
Sarita Devi, Arpita Mukhopadhyay, Pratibha Dwarkanath, Tinku Thomas, Julian Crasta, Annamma Thomas, C N Sheela, Jean W Hsu, Grace J Tang, Farook Jahoor, Anura V Kurpad
Background: Low-quality dietary protein intake and vitamin B-12 deficiency could interact to decrease methionine transmethylation and remethylation rates during pregnancy and may affect epigenetic modifications of the fetal genome.Objective: The objective of this randomized, partially open-labeled intervention trial was to examine the effect of supplemental high-quality protein and vitamin B-12 on third-trimester methionine kinetics in pregnant Indian women with a low vitamin B-12 status.Methods: Pregnant women with low serum vitamin B-12 concentrations (<200 pmol/L) were randomly assigned to 1 of 3 groups: the first group received balanced protein-energy supplementation of 500 mL milk/d plus a 10-μg vitamin B-12 tablet/d (M+B-12 group; n = 30), the second group received milk (500 mL/d) plus a placebo tablet (M+P group; n = 30), and the third group received a placebo tablet alone (P group; n = 33)...
April 26, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28446262/dietary-supplementation-of-branched-chain-amino-acids-increases-muscle-net-amino-acid-fluxes-through-elevating-their-substrate-availability-and-intramuscular-catabolism-in-young-pigs
#3
Liufeng Zheng, Fangrui Zuo, Shengjun Zhao, Pingli He, Hongkui Wei, Quanhang Xiang, Jiaman Pang, Jian Peng
Branched-chain amino acids (BCAA) have been clearly demonstrated to have anabolic effects on muscle protein synthesis. However, little is known about their roles in the regulation of net AA fluxes across skeletal muscle in vivo. This study was aimed to investigate the effect and related mechanisms of dietary supplementation of BCAA on muscle net amino acid (AA) fluxes using the hindlimb flux model. In all fourteen 4-week-old barrows were fed reduced-protein diets with or without supplemental BCAA for 28 d. Pigs were implanted with carotid arterial, femoral arterial and venous catheters, and fed once hourly with intraarterial infusion of p-amino hippurate...
April 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28434720/short-and-longer-term-effects-of-feeding-increased-metwabolizable-protein-with-or-without-an-altered-amino-acid-profile-to-dairy-cows-immediately-postpartum
#4
E G Carder, W P Weiss
The first few weeks after parturition is marked by low, but increasing feed intake and sharply increasing milk production by dairy cows. Because of low intake, the nutrient density of the diet may need to be higher during this period to support increasing milk yields. We hypothesized that feeding higher levels of metabolizable protein (MP) or a protein supplement with rumen-protected lysine and methionine during the immediate postpartum period would increase yields of milk and milk components. Fifty-six Holstein cows (21 primiparous and 35 multiparous) starting at 3 d in milk were used in a randomized block design...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28432198/folate-dependent-methylation-of-septins-governs-ciliogenesis-during-neural-tube-closure
#5
Manami Toriyama, Michinori Toriyama, John B Wallingford, Richard H Finnell
Periconception maternal folic acid (vitamin B9) supplementation can reduce the prevalence of neural tube defects (NTDs), although just how folates benefit the developing embryo and promote closing of the neural tube and other morphologic processes during development remains unknown. Folate contributes to a 1-carbon metabolism, which is essential for purine biosynthesis and methionine recycling and affects methylation of DNA, histones, and nonhistone proteins. Herein, we used animal models and cultured mammalian cells to demonstrate that disruption of the methylation pathway mediated by folate compromises normal neural tube closure (NTC) and ciliogenesis...
April 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28424329/a-paternal-diet-for-offspring-success
#6
Christopher Hine
Supplementation of the diet of male mice with methyl donors, such as methionine and folic acid, prior to mating impaired learning, memory, and metabolic functions in the offspring.
April 19, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28421128/a-clinically-relevant-variant-of-the-human-hydrogen-sulfide-synthesizing-enzyme-cystathionine-%C3%AE-synthase-increased-co-reactivity-as-a-novel-molecular-mechanism-of-pathogenicity
#7
João B Vicente, Henrique G Colaço, Francesca Malagrinò, Paulo E Santo, André Gutierres, Tiago M Bandeiras, Paula Leandro, José A Brito, Alessandro Giuffrè
The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5'-phosphate- (PLP-) dependent cystathionine β-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen sulfide (H2S). CBS activity, contributing to cellular redox homeostasis, is positively regulated by S-adenosyl-L-methionine (AdoMet) but fully inhibited upon CO or NO• binding to a noncatalytic heme moiety. Despite extensive studies, the molecular basis of several pathogenic CBS mutations is not yet fully understood...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28419366/effect-of-methionine-supplementation-in-chicken-feed-on-the-quality-and-shelf-life-of-fresh-poultry-meat
#8
Antonia Albrecht, Ulrike Herbert, Dennis Miskel, Celine Heinemann, Carina Braun, Sophia Dohlen, Johanna O Zeitz, Klaus Eder, Behnam Saremi, Judith Kreyenschmidt
The aim of this study was to investigate the influence of different methionine sources and concentrations on the quality and spoilage process of broiler meat. The trial was comprised of 7 treatment groups: one basal group (suboptimal in Methionine+Cysteine; i.e., 0.89, 0.74, 0.69% in DM SID Met+Cys in starter, grower, and finisher diets, respectively) and 3 doses (0.10, 0.25, and 0.40%) of either DL-Methionine (DLM) or DL-2-hydroxy-4-methylthio butanoic acid (DL-HMTBA) on an equimolar basis of the DLM-supplemented groups...
April 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28414519/effect-of-a-food-supplement-containing-l-methionine-on-urinary-tract-infections-in-pregnancy-a-prospective-multicenter-observational-study
#9
Mario Passaro, Giampaolo Mainini, Francesco Ambrosio, Raimondo Sgambato, Giancarlo Balbi
OBJECTIVE: Adjuvants or alternatives to antibiotics in urinary tract infections (UTIs) during pregnancy seem advisable because of possible fetal stress. The present study assessed the effectiveness of a food supplement containing L-methionine and Hibiscus sabdariffa L. and Boswellia serrata Roxb. extracts as a treatment for symptomatic UTIs in pregnancy. DESIGN: Pregnant patients with symptomatic cystitis were screened for UTIs in three different clinical centers...
April 17, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28398657/study-exploring-the-effects-of-daily-supplementation-with-400-%C3%AE-g-of-folic-acid-on-the-nutritional-status-of-folate-in-women-of-reproductive-age
#10
Laidy D Arias, Beatriz E Parra, Angélica M Muñoz, Diana L Cárdenas, Tiffany G Duque, Luz M Manjarrés
BACKGROUND: This investigation determines the nutritional state of serum and red blood cell (RBC) folate concentration and their relation with intake of folate, B6 ,and B12 , with serum vitamin B12 , and with genetic variants after provision of 400 μg/day of folic acid for 3 months to a group of 34 Colombian women of reproductive age. METHODS: We evaluated nutrient intake using 24-hr recall, assessing the levels of serum folate, RBC folate, serum B12 , and homocysteine, as well as determining genetic variants of the enzyme MTHFR (C677T and A1298C) and CβS (844ins68pb)...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28368295/homocysteine-induces-hepatic-steatosis-involving-er-stress-response-in-high-methionine-diet-fed-mice
#11
Yanbiao Ai, Zhenzhen Sun, Chuan Peng, Lingli Liu, Xiaoqiu Xiao, Jibin Li
Elevated circulating homocysteine (Hcy) has been proposed to be associated with non-alcoholic fatty liver disease (NAFLD). It is also reported that Hcy causes protein misfolding in the endoplasmic reticulum (ER). In this study, we used a high methionine diet (HMD)-fed mouse model and cultured primary hepatocytes to investigate the effects of Hcy on hepatic lipids metabolism. C57BL/6J mice received either standard chow diet (CT, n = 10) or diet supplemented with 2% methionine (MET, n = 10) for 16 weeks. In in vitro experiments, cultured mouse primary hepatocytes were treated with Hcy, or Hcy combined with 4-phenylbutyric acid (4-PBA), or tunicamycin (TM), respectively...
April 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28365916/pigment-epithelium-derived-factor-pedf-prevents-hepatic-fat-storage-inflammation-and-fibrosis-in-dietary-steatohepatitis-of-mice
#12
Takafumi Yoshida, Jun Akiba, Takanori Matsui, Kazuo Nakamura, Takao Hisamoto, Mitsuhiko Abe, Yu Ikezono, Fumitaka Wada, Hideki Iwamoto, Toru Nakamura, Hironori Koga, Sho-Ichi Yamagishi, Takuji Torimura
BACKGROUND AND AIMS: Pigment epithelium-derived factor (PEDF) has been shown to be a potent inhibitor of inflammation through its anti-oxidative property. Since oxidative response is considered to play the pivotal role of the development and progression of nonalcoholic steatohepatitis (NASH), it is conceivable that PEDF may play a protective role against NASH. In this study, we examined whether administration of PEDF slowed the progression of NASH in mice models. METHODS: Mice were fed methionine- and choline-deficient (MCD) diet with or without intramuscular administration of adenovirus-expressing PEDF (Ad-PEDF)...
April 1, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28358240/molecular-mr-imaging-of-myeloperoxidase-distinguishes-steatosis-from-steatohepatitis-in-nonalcoholic-fatty-liver-disease
#13
Benjamin Pulli, Gregory Wojtkiewicz, Yoshiko Iwamoto, Muhammad Ali, Matthias W Zeller, Lionel Bure, Cuihua Wang, Yuri Choi, Ricard Masia, Alex R Guimaraes, Kathleen E Corey, John W Chen
Purpose To test whether myeloperoxidase (MPO) with bis-5-hydroxytryptamide-diethylenetriaminepentaacetate-gadolinium (MPO-Gd), an activatable molecular magnetic resonance (MR) imaging agent specific for MPO activity, could detect MPO activity in nonalcoholic steatohepatitis (NASH) mouse models and human liver biopsy samples. Materials and Methods In this study, 20 leptin receptor-deficient and three MPO knockout mice were injected with endotoxin (lipopolysaccharide) or fed a methionine and choline-deficient (MCD) diet to induce experimental NASH and underwent MR imaging with MPO with MPO-Gd...
March 30, 2017: Radiology
https://www.readbyqxmd.com/read/28351018/profiles-of-amino-acids-and-biogenic-amines-in-the-plasma-of-cri-du-chat-patients
#14
Danielle Zildeana Sousa Furtado, Fernando Brunale Vilela de Moura Leite, Cleber Nunes Barreto, Bernadete Faria, Leticia Dias Lima Jedlicka, Elisângela de Jesus Silva, Heron Dominguez Torres da Silva, Etelvino Jose Henriques Bechara, Nilson Antonio Assunção
Cri-du-chat syndrome (CDCS) is a rare innate disease attributed to chromosome 5p deletion characterized by a cat-like cry, craniofacial malformation, and altered behavior of affected children. Metabolomic analysis and a chemometric approach allow description of the metabolic profile of CDCS as compared to normal subjects. In the present work, UHPLC/MS was employed to analyze blood samples withdrawn from CDCS carriers (n=18) and normal parental subjects (n=18), all aged 0-34 years, aiming to set up a representative CDCS profile constructed from 33 targeted amino acids and biogenic amines...
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28325574/decoy-receptor-3-analogous-supplement-protects-steatotic-rat-liver-from-ischemia-reperfusion-injury
#15
Tzu-Hao Li, Chih-Wei Liu, Pei-Chang Lee, Chia-Chang Huang, Kuei-Chuan Lee, Yun-Cheng Hsieh, Ying-Ying Yang, Shie-Liang Hsieh, Han-Chieh Lin, Chang-Youh Tsai
BACKGROUND: For steatotic livers, pharmacological approaches to minimize the hepatic neutrophil and macrophage infiltration, and cytokine and chemokine release in ischemia-reperfusion (IR) injury are still limited. Tumor necrosis factor (TNF)-α superfamily-stimulated pathogenic cascades and M1 macrophage/Kupffer cells (KC) polarization from Th1 cytokines are important in the pathogenesis of IR liver injury with hepatic steatosis (HS). Conversely, anti-inflammatory M2 macrophages produce Th2 cytokine (interleukin-4), which reciprocally enhances M2 polarization...
March 16, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28319060/the-anti-diabetic-drug-exenatide-a-glucagon-like-peptide-1-receptor-agonist-counteracts-hepatocarcinogenesis-through-camp-pka-egfr-stat3-axis
#16
M Zhou, M T S Mok, H Sun, A W Chan, Y Huang, A S L Cheng, G Xu
Epidemiological studies have demonstrated a close association of type 2 diabetes and hepatocellular carcinoma (HCC). Exenatide (Ex-4), a potent diabetes drug targeting glucagon-like peptide-1 receptor (GLP-1R), is protective against non-alcoholic fatty liver disease (NAFLD). However, the Ex-4 function and GLP-1R status have yet been explored in HCC. Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet. Administration of Ex-4 significantly improved obesity-induced hyperglycemia and hyperlipidemia and reduced HCC multiplicity in obese DEN-treated mice, in which suppressed proliferation and induced apoptosis were confined to tumor cells...
March 20, 2017: Oncogene
https://www.readbyqxmd.com/read/28318590/supplementation-with-rumen-protected-methionine-or-choline-during-the-transition-period-influences-whole-blood-immune-response-in-periparturient-dairy-cows
#17
M Vailati-Riboni, Z Zhou, C B Jacometo, A Minuti, E Trevisi, D N Luchini, J J Loor
Methionine, together with Lys, is the most limiting AA for milk production in dairy cows. Besides its crucial role in milk production, Met and its derivate metabolites (e.g., glutathione, taurine, polyamines) are well-known immunonutrients in nonruminants, helping support and boost immune function and activity. In the present study, the effects of Met or choline, as its precursor, were investigated using an ex vivo whole blood challenge. The study involved 33 multiparous Holstein cows (from a larger cohort with a factorial arrangement of treatments) assigned from d -21 to +30 relative to parturition to a basal control (CON) diet, CON plus rumen-protected Met (MET, Smartamine M, Adisseo NA, Alpharetta, GA) at a rate of 0...
May 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28316020/%C3%AE-hydroxybutyrate-boosts-mitochondrial-and-neuronal-metabolism-but-is-not-preferred-over-glucose-under-activated-conditions
#18
Lavanya B Achanta, Benjamin D Rowlands, Donald S Thomas, Gary D Housley, Caroline D Rae
The ketone body, β-hydroxybutyrate (βOHB), is metabolised by the brain alongside the mandatory brain fuel glucose. To examine the extent and circumstances by which βOHB can supplement glucose metabolism, we studied guinea pig cortical brain slices using increasing concentrations of [U-(13)C]D-βOHB in conjunction with [1-(13)C]D-glucose under conditions of normo- and hypoglycaemia, as well as under high potassium (40 mmol/L K(+)) depolarization in normo- and hypoglycaemic conditions. The contribution of βOHB to synthesis of GABA was also probed by inhibiting the synthesis of glutamine, a GABA precursor, with methionine sulfoximine (MSO)...
March 18, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28284854/effects-of-graded-dietary-levels-of-soy-protein-concentrate-supplemented-with-methionine-and-phosphate-on-the-immune-and-antioxidant-responses-of-gilthead-sea-bream-sparus-aurata-l
#19
Fotini Kokou, Elena Sarropoulou, Efthimia Cotou, Maroudio Kentouri, Maria Alexis, George Rigos
The effects of a dietary soy protein concentrate (SPC) as a fish meal (FM) substitute, on selected innate immune responses, the oxidative status, hepatic and intestinal morphology of gilthead sea bream, Sparus aurata, were evaluated after a three-month feeding trial. Isonitrogenous (45% crude protein) and isoenergetic (23 kJ/g gross energy) diets with 20% (SPC20), 40% (SPC40) and 60% (SPC60) of SPC inclusion, supplemented with methionine and phosphate, were evaluated against a diet containing FM as the sole protein source...
May 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28279791/methionine-hydroxy-analogue-improves-intestinal-immunological-and-physical-barrier-function-in-young-grass-carp-ctenopharyngodon-idella
#20
Fei-Yu Pan, Pei Wu, Lin Feng, Wei-Dan Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou, Yang Liu
This study was conducted to test the hypothesis that methionine hydroxy analogue (MHA) enhances the defense against enteritis occurrence via improving intestinal barrier function in fish. After 630 young grass carp (Ctenopharyngodon idella) (259.70 ± 0.47 g) fed six graded levels of MHA (0, 2.4, 4.4, 6.4, 8.5 and 10.5 g/kg diet) and one dl-methionine group (6.4 g/kg diet) for 8 weeks. At the end of feeding trial, 15 fish from each treatment were challenged with Aeromonas hydrophila for 14 days. The results indicated that optimal MHA enhanced the capacity of fish against enteritis emergence, which might be related to the positive effects of MHA on intestinal immunological and physical barrier function in fish...
May 2017: Fish & Shellfish Immunology
keyword
keyword
104735
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"