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Methionine supplement

Zeinab Khoobbakht, Mehrdad Mohammadi, Mohammad Roostaei-Ali Mehr, Fahimeh Mohammadghasemi, Mohammad Mehdi Sohani
The objective was to examine the effect of different dietary zinc sources on reproduction of male Japanese quail. A total of 512 quail chicks (day-old) were divided into four groups with four replications for a period of 42 days. After this period, excess chicks were removed to attain the ratio of one male to three females and 16 quail in each subgroup. At 52 to 60 d of age, the eggs were collected and incubated. The basal diet (control) contained no zinc and the other three experimental diets were supplemented with 25 and 50 mg/kg zinc from zinc oxide (ZnO), zinc oxide nanoparticles (ZnONP) and zinc-methionine (Zn-Met) for 1 to 35 and 36 to 60 days, respectively...
February 23, 2018: Animal Reproduction Science
Imtiaz Hussain Raja Abbasi, Farzana Abbasi, Mohamed E Abd El-Hack, Ayman A Swelum, Junhu Yao, Yangchun Cao
Microbial degradation in the rumen and dietary availability of methionine amino acid have been reported as limiting in dairy ruminants. The aim of the present study was to examine the post-ruminal effects of feeding ruminants different concentrations of rumen-protected methionine (RPM) in low crude protein diets using the long-term rumen simulation method (Rusitec) followed by in vitro abomasum and ileum digestibility technique. The experiment contained four treatment groups: (1) high protein, without RPM supplementation (HP); (2) low protein, without RPM supplementation (LP); (3) low protein supplementation with low RPM (LPLM); and (4) low protein supplementation with high RPM (LPHM) mixed per 20 ± 0...
March 9, 2018: AMB Express
Chie Furuta, Hitoshi Murakami
BACKGROUNDS/AIMS: This study was aimed at understanding the relationship between plasma amino acids and protein malnutrition and at determining whether amino acid supplementation associated with malnutrition and growth improves linear growth in growing rats. METHODS: Body length and plasma amino acids were measured in young male rats that were fed the following diet for 3 weeks, mimicking a low and imbalanced protein diets based on maize, a major staple consumed in developing countries: a 70% calorically restricted cornmeal-based diet (C), C + micronutrients (CM), CM + casein (CMC), CM + soy protein (CMS) or CMS + 0...
March 8, 2018: Annals of Nutrition & Metabolism
Jie An, Liping Wang, Michael L Patnode, Vanessa K Ridaura, Jonathan M Haldeman, Robert D Stevens, Olga Ilkayeva, James R Bain, Michael J Muehlbauer, Erin L Glynn, Steven Thomas, Deborah Muoio, Scott A Summers, James E Vath, Thomas E Hughes, Jeffrey I Gordon, Christopher B Newgard
Current obesity interventions suffer from lack of durable effects and undesirable complications. Fumagillin, an inhibitor of methionine aminopeptidase-2, causes weight loss by reducing food intake, but with effects on weight that are superior to pair-feeding. Here, we show that feeding of rats on a high-fat diet supplemented with fumagillin (HF/FG) suppresses the aggressive feeding observed in pair-fed controls (HF/PF) and alters expression of circadian genes relative to the HF/PF group. Multiple indices of reduced energy expenditure are observed in HF/FG but not HF/PF rats...
March 8, 2018: JCI Insight
P Jariyahatthakij, B Chomtee, T Poeikhampha, W Loongyai, C Bunchasak
This study was conducted to evaluate the effects of supplementing methionine (Met) in a low-protein (Low-CP) diet during d 11 to 24 and subsequently feeding with a low-metabolizable energy diet (Low-ME; -75 kcal/kg) or a normal ME diet during d 25 to 42 on the productive performance, blood chemical profile, and lipid metabolism-related gene expression of broiler chickens. The 1,600 broiler chicks were divided into 5 groups as follows: 1) Normal CP, then Normal ME; 2) Low-CP, then Normal ME; 3) Low-CP, then Low-ME; 4) Low-CP+Met, then Normal ME; and 5) Low-CP+Met, then Low-ME...
March 5, 2018: Poultry Science
Shuai Zhang, Elizabeth R Gilbert, Kevin J T Noonan, Behnam Saremi, Eric A Wong
Common dietary supplemental methionine (Met) sources include DL-methionine (DL-Met) and the Met precursor DL-2-hydroxy-4-(methylthio) butanoic acid (DL-HMTBA). For bio-utilization, D-Met and DL-HMTBA are converted into L-Met through oxidation and transamination. The objective of this study was to determine the effect of different dietary supplemental Met sources on gene expression and enzyme activity of Met oxidases in male broiler chickens. Liver, muscle, duodenum, jejunum, and ileum were collected at days 10 (d 10), 21 (d 21), and 26 (d 26) post-hatch from male broiler chickens that were fed a basal diet deficient in sulfur amino acids (SAA) (control), or the control diet supplemented with DL-Met, L-Met, or DL-HMTBA to meet SAA requirements...
March 5, 2018: Poultry Science
Cristian Del Bo', Patrizia Riso, Claudio Gardana, Antonella Brusamolino, Alberto Battezzati, Salvatore Ciappellano
BACKGROUND & AIMS: Vegetarians and vegans are more vulnerable to vitamin B12 deficiency with severe risks of megaloblastic anemia, cognitive decline, neuropathy, and depression. An easy and simple method of supplementation consists of taking one weekly dosage of 2000 μg. However, single large oral doses of vitamin B12 are poorly absorbed. The present research evaluates the ability of two different sublingual dosages of vitamin B12 (350 μg/week vs 2000 μg/week) in improving cyanocobalamin (vitamin B12 ) nutritional status in vegans and vegetarians with a marginal deficiency...
February 15, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Eun Ju Yun, James Lee, Do Hyoung Kim, Jungyeon Kim, Sooah Kim, Yong-Su Jin, Kyoung Heon Kim
Lipid production by oleaginous Yarrowia lipolytica depends highly on culture environments, such as carbon sources, carbon/nitrogen (C/N) ratios, types of media, and cellular growth phases. In this study, the effects of media and carbon sources on lipid and metabolite production were investigated by profiling fatty acids and intracellular metabolites of Y. lipolytica grown in various media. The highest total fatty acid yield 114.04 ± 6.23 mg/g dry cell weight was achieved by Y. lipolytica grown in minimal medium with glycerol (SCG) in the exponential phase...
February 27, 2018: Journal of Biotechnology
Eyup Eren Gultepe, Cangir Uyarlar, İsmail Bayram
This study aimed to investigate the effect of dietary chromium methionine (Cr-Met) supplementation on the production and immunological parameters of dairy cows during the dry and postpartum period and their offspring. Forty-five Holstein transition cows were randomly assigned to experimental groups with control, positive control (levamisole-injected cows), and treatment groups (5 g dietary Cr-Met/day/cow). Production, immunological, and biochemical parameters were analyzed during the dry and postpartum period...
March 1, 2018: Biological Trace Element Research
Soo Jin Yang, Hyun Ju Do, Youngae Jung, Geum-Sook Hwang, Min-Jeong Shin
The alpha-glucosidase inhibitor voglibose (VO) was recently reported to have a protective effect against weight gain as well as affect various metabolic changes related to food intake and gut-brain signaling. We hypothesized that VO prevents weight gain by altering neurometabolome profiles in the hypothalamus to reduce food intake. To test this hypothesis, we assessed metabolite profiles in the hypothalamus of standard diet- or high-fat (HF) diet-fed mice in the absence or presence of VO. In total, 29 male C57BL/6 mice were divided into 3 groups: (1) lean control, (2) HF, and (3) HF + VO...
March 1, 2018: Nutritional Neuroscience
M Abedini, F Shariatmadari, M A Karimi Torshizi, H Ahmadi
The objective of this study was to evaluate the effects of dietary supplementation with zinc oxide nanoparticles (ZnO-NPs) on the performance, egg quality, Zn retention, immunity responses, superoxide dismutase activity (SOD), egg malondialdehyde (MDA) content, and serum parameters in laying hens in the late phase of production. A total of 288 laying hens at 64 weeks of age were randomly assigned to 4 treatments with 6 replicates, and 12 birds within each group. Experimental diets included a corn-soybean meal-based diet (without Zn supplementation) and a basal diet supplemented with 80 mg/kg of Zn-oxide, ZnO-NPs, and Zn-methionine...
February 28, 2018: Journal of Animal Physiology and Animal Nutrition
Joshua D Bryant, Shannon R Sweeney, Enrique Sentandreu, Minhye Shin, Helene Ipas, Blerta Xhemalce, Jessica Momb, Stefano Tiziani, Dean R Appling
One-carbon (1C) metabolism is a universal folate-dependent pathway essential for de novo purine and thymidylate synthesis, amino acid interconversion, universal methyl-donor production, and regeneration of redox cofactors. Homozygous deletion of the 1C pathway gene Mthfd1l encoding methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like, which catalyzes mitochondrial formate production from 10-formyltetrahydrofolate, results in 100% penetrant embryonic neural tube defects (NTDs), underscoring the central role of mitochondrially derived formate in embryonic development and providing a mechanistic link between folate and NTDs...
February 26, 2018: Journal of Biological Chemistry
Seo-Young Park, Thomas M Reimonn, Cyrus Agarabi, Kurt Brorson, Seongkyu Yoon
Amino acids and glucose consumption, cell growth and monoclonal antibody (mAb) production in mammalian cell culture are key considerations during upstream process and particularly media optimization. Understanding the interrelations and the relevant cellular physiology will provide insight for setting strategy of robust and effective mAb production. The aim of this study was to further our understanding of nutrient consumption metabolism, since this could have significant impact on enhancing mAb titer, cell proliferation, designing feeding strategies, and development of feed media...
February 21, 2018: Biotechnology Progress
Mohamed K Abdelmegeid, Ahmed A Elolimy, Zheng Zhou, Vincenzo Lopreiato, Joshua C McCann, Juan J Loor
Background: Extensive degradation of amino acids in the rumen via microbial deamination decreases the post-ruminal availability of dietary indispensable amino acids. Together with the normal decrease in voluntary dry matter intake (DMI) around parturition in dairy cows, microbial metabolism contributes to a markedly negative balance of indispensable amino acids, including methionine which may be the first-limiting for milk production. The main objective of the current study was to profile changes in major bacterial species with key functions in cellulose and hemicellulose digestion, xylan breakdown, proteolytic action, propionic acid production, lactate utilization and ruminal biohydrogenation in cows supplemented with rumen-protected Methionine (SM; Smartamine M, Adisseo NA, Alpharetta, GA, USA) from -23 through 30 d relative to parturition...
2018: Journal of Animal Science and Biotechnology
M Stojanović, D Todorović, Lj Šćepanović, D Mitrović, S Borozan, V Dragutinović, M Labudović-Borović, D Krstić, M Čolović, D Djuric
The aim of this study was to assess the effects of L-cysteine (Cys) (7 mg/kg) and N-acetyl-L-cysteine (NAC) (50 mg/kg) in the rat liver caused by subchronic i.p. application of methionine (Met) (0.8 mmol/kg) during 21 days. Malondialdehyde (MDA) concentration, glutathione content (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and acetylcholinesterase (AchE) activities were determined in the liver tissue and activities of liver enzymes (AST, ALT, ALP, and GGT) and concentrations of total proteins and albumin were determinated in plasma/serum...
February 8, 2018: Molecular and Cellular Biochemistry
Myriam Visram, Maja Radulovic, Sabine Steiner, Nermina Malanovic, Thomas O Eichmann, Heimo Wolinski, Gerald N Rechberger, Oksana Tehlivets
S-adenosyl-L-homocysteine hydrolase (AdoHcy hydrolase; Sah1 in yeast/AHCY in mammals) degrades AdoHcy, a byproduct and strong product inhibitor of S-adenosyl-L-methionine (AdoMet)-dependent methylation reactions, to adenosine and homocysteine (Hcy). This reaction is reversible, so any elevation of Hcy levels, such as in hyperhomocysteinemia (HHcy), drives the formation of AdoHcy, with detrimental consequences for cellular methylation reactions. HHcy, a pathological condition linked to cardiovascular and neurological disorders as well as fatty liver amongst others, is associated with a deregulation of lipid metabolism...
February 6, 2018: Journal of Biological Chemistry
Roberto Carlos Burini, Maria Doroteia Borges-Santos, Fernando Moreto, Yong- Ming Yu
In this study, an acute overloading of methionine (MetLo) was used to investigate the trassulfuration pathway response comparing healthy controls and HIV+ patients under their usual diet and dietary N-acetyl-L-cysteine (NAC) supplementation. MetLo (0.1 g Met/kg mass weight) was given after overnight fasting to 20 non-HIV+ control subjects (Co) and 12 HIV+ HAART-treated patients. Blood samples were taken before and after the MetLo in two different 7-day dietary situations, with NAC (1 g/day) or with their usual diet (UD)...
February 1, 2018: Amino Acids
Shun-Li Cao, Hong Jiang, Shi-Ping Niu, Xiao-Hu Wang, Shan Du
OBJECTIVE: To summarize the available randomized controlled trials (RCTs) to evaluate the effect of taurine supplementation on growth in low birth weight infants (LBW). METHODS: PubMed, EmBase, and Cochrane Library electronic databases were searched for published articles through March 2017. Analysis was done to examine the effect of taurine supplementation on growth, and sensitivity analysis was performed by removing each individual study from meta-analysis. RESULTS: Results of 9 trials totaling 216 LBW infants in the present meta-analysis were collected and analyzed...
January 25, 2018: Indian Journal of Pediatrics
C A Pontin, S L Vieira, C Stefanello, M Kipper, L Kindlein, C T Simões, R Gonzalez-Esquerra
As the first limiting amino acid in corn-soy broiler diets, methionine (Met) is supplemented using commercial synthetic sources as demanded to obtain economic feed formulations. The Met analogue DL-2-hydroxy-4-(methylthio)-butanoic acid (HMTBA) is largely utilized with that objective. This study intended to obtain responses of broilers fed with increasing levels of HMTBA, from 28 to 42 d, such that economic returns can be calculated. A total of 2,106 Cobb × Cobb 500 one-day-old male broilers was randomly placed in 81 floor pens (2...
January 20, 2018: Poultry Science
Pei Wu, Fei-Yu Pan, Lin Feng, Wei-Dan Jiang, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou, Yang Liu
This study was conducted to investigate the effects of methionine hydroxy analogue (MHA) on the physical barrier and immune defence in the gill of young grass carp (Ctenopharyngodon idella). A total 630 young grass carp with an average initial weight of 259.70 ± 0.47 g were fed graded levels of MHA (0, 2.4, 4.4, 6.4, 8.5 and 10.5 g/kg diet) and one DL-methionine (DLM) group (6.4 g/kg diet) for 8 weeks. After feeding trial, 15 fish from each treatment were challenged with Flavobacterium columnare...
January 19, 2018: Fish & Shellfish Immunology
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