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https://www.readbyqxmd.com/read/28431024/radiosurgery-for-unruptured-brain-arteriovenous-malformations-an-international-multicenter-retrospective-cohort-study
#1
Dale Ding, Robert M Starke, Hideyuki Kano, John Y K Lee, David Mathieu, John Pierce, Paul Huang, Symeon Missios, Caleb Feliciano, Rafael Rodriguez-Mercado, Luis Almodovar, Inga S Grills, Danilo Silva, Mahmoud Abbassy, Douglas Kondziolka, Gene H Barnett, L Dade Lunsford, Jason P Sheehan
BACKGROUND: The role of intervention in the management of unruptured brain arteriovenous malformations (AVM) is controversial. OBJECTIVE: To analyze in a multicenter, retrospective cohort study, the outcomes following radiosurgery for unruptured AVMs and determine predictive factors. METHODS: We evaluated and pooled AVM radiosurgery data from 8 institutions participating in the International Gamma Knife Research Foundation. Patients with unruptured AVMs and ≥12 mo of follow-up were included in the study cohort...
April 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28430798/evaluation-of-mature-soybean-pods-as-a-food-source-for-two-pod-sucking-bugs-riptortus-pedestris-hemiptera-alydidae-and-halyomorpha-halys-hemiptera-pentatomidae
#2
M Mahbubur Rahman, Un Taek Lim
Riptortus pedestris (Fabricius) and Halyomorpha halys (Stål) cause injury to soybeans by piercing and sucking pods and seeds. Growers believe that new damage decreases near to harvest despite the occurrence of these bugs at that time. As this question has never been assessed, we evaluated two diets: a) mature soybean pods (dried shell + dried soybean seeds) and b) dried soybean seeds for the two bugs by assessing their biological, behavioral, and morphological attributes on each diet in laboratory. While nymphs of both species were able to develop and adults able to reproduce on the tested diets, bugs fed on pods had longer development times and 2...
2017: PloS One
https://www.readbyqxmd.com/read/28430072/nonexceptionalism-research-risks-and-social-media-response-to-open-peer-commentaries-on-using-social-media-as-a-research-recruitment-tool-ethical-issues-and-recommendations
#3
Luke Gelinas, Robin Pierce, Sabune Winkler, Glenn Cohen, Holly Fernandez Lynch, Barbara E Bierer
No abstract text is available yet for this article.
May 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28427775/nonoperative-management-of-atypical-endometrial-hyperplasia-and-grade-1-endometrial-cancer-with-the-levonorgestrel-intrauterine-device-in-medically-ill-post-menopausal-women
#4
William D Baker, Stuart R Pierce, Anne M Mills, Paola A Gehrig, Linda R Duska
OBJECTIVE: To assess the endometrial response rates to treatment with the levonorgestrel intrauterine device in post-menopausal women with atypical hyperplasia/endometrial intraepithelial neoplasia and grade 1 endometrioid (AH/EC) endometrial carcinoma who are not surgical candidates. METHODS: Chart review was undertaken of patients with AH/EC who underwent levonorgestrel intrauterine device insertion by a gynecologic oncologist within two academic health systems between 2002 and 2013...
April 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28425301/development-of-a-novel-rationally-designed-antibiotic-to-inhibit-a-nontraditional-bacterial-target
#5
Pavel Dibrov, Elena Dibrov, Thane G Maddaford, Melissa Kenneth, Jordan Nelson, Craig Resch, Grant N Pierce
The search for new nontraditional targets is a high priority in antibiotic design today. Bacterial membrane energetics based on sodium ion circulation offers potential alternative targets. The present work identifies the Na(+)-translocating NADH:ubiquinone oxidoreductase (Na(+)-NQR), a key respiratory enzyme in many microbial pathogens, as indispensible for the Chlamydia trachomatis infectious process. Infection by Chlamydia trachomatis significantly increased first H(+) and then Na(+) levels within the host mammalian cell...
April 20, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28425145/prevalence-of-gastroesophageal-reflux-in-cats-during-anesthesia-and-effect-of-omeprazole-on-gastric-ph
#6
R S Garcia, P C Belafsky, A Della Maggiore, J M Osborn, B H Pypendop, T Pierce, V J Walker, A Fulton, S L Marks
BACKGROUND: Gastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation. OBJECTIVE: To determine whether pre-anesthetic orally administered omeprazole increases gastric and esophageal pH and increases serum gastrin concentrations in anesthetized cats, and to determine the prevalence of GER using combined multichannel impedance and pH monitoring. ANIMALS: Twenty-seven healthy cats undergoing elective dental procedures...
April 19, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28420007/accessory-spleen-in-the-greater-omentum-embryology-and-revisited-prevalence-rates
#7
Nikita Gill, Areeba Nasir, Jennifer Douglin, Bettina Pretterklieber, Hanno Steinke, Michael Pretterklieber, Sebastian Cotofana
PURPOSE: To investigate in a large sample the prevalence rates of accessory spleens located in the greater omentum and to explain the embryological background and the vascular supply of this rare congenital disorder. METHODS: Evaluation of the presence of accessory spleens located in the greater omentum was performed in 5 different international anatomical centers investigating a total of 1,045 body donors. Arterial and venous blood supply and the precise location of the respective vasculature within the splenic ligaments are described based on dissection of this rare condition in a male specimen...
April 19, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28418576/the-safe-zone-technique-improves-suture-placement-and-accuracy-during-arthroscopic-remplissage
#8
Grant H Garcia, Ryan M Degen, Joseph N Liu, Cynthia A Kahlenberg, Daniel J Hurwit, Joshua S Dines
In response to recent concerns about the accuracy of suture passage during arthroscopic remplissage, this study was conducted to determine whether a previously described "safe zone" technique can improve the accuracy of suture passage. A recommended safe zone technique was used for arthroscopic remplissage on 6 cadaveric specimens. The safe zone was described as a region at least 1 cm lateral and no greater than 3 cm distal to the posterolateral acromion. Results were compared with a control group of 6 specimens for which the safe zone technique was not used...
April 18, 2017: Orthopedics
https://www.readbyqxmd.com/read/28417330/management-of-nasal-fractures-in-sports
#9
Yashika Patel, Peter Goljan, Todd P Pierce, Anthony Scillia, Kimona Issa, Vincent K McInerney, Anthony Festa
Nasal fractures represent approximately 60% of all maxillofacial injuries that occur in athletic activities; however, there are no current guidelines regarding immediate sideline management of these injuries. Therefore, the purpose of this article was to (1) summarize the anatomy, etiology, and incidence of nasal fractures, and (2) evaluate the current body of literature regarding immediate on-field and subsequent outpatient management. It is imperative to establish that the athlete's airway is not compromised and there are no other severe concomitant injuries, such as a concussion, ocular injury, or leakage of cerebrospinal fluid...
April 17, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28413118/cadaveric-and-ultrasonographic-validation-of-needling-placement-in-the-cervical-multifidus-muscle
#10
César Fernández-de-Las-Peñas, Juan A Mesa-Jiménez, Jose A Paredes-Mancilla, Shane L Koppenhaver, Samuel Fernández-Carnero
OBJECTIVE: The aim of this study was to determine if a needle is able to reach the cervical multifidus during the application of dry needling or acupuncture. METHODS: Dry needling and ultrasound imaging of cervical multifidi was conducted on 5 patients (age: 32 ± 5 years) with mechanical neck pain and on 2 fresh cadavers (age: 64 ± 1 years). Dry needling was done using a needle of 40 mm in length inserted perpendicular to the skin about 1 cm lateral to the spinous process at C3-C4...
April 13, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28412059/a-systematic-review-of-tennis-elbow-surgery-open-versus-arthroscopic-versus-percutaneous-release-of-the-common-extensor-origin
#11
REVIEW
Todd P Pierce, Kimona Issa, Benjamin T Gilbert, Brian Hanley, Anthony Festa, Vincent K McInerney, Anthony J Scillia
PURPOSE: To compare complications, function, pain, and patient satisfaction after conventional open, percutaneous, or arthroscopic release of the extensor origin for the treatment of lateral epicondylitis. METHODS: A thorough review of 4 databases-PubMed, EBSCOhost, CINAHL (Cumulative Index to Nursing and Allied Health Literature) Plus, and Scopus-was performed to identify all studies that addressed surgical management of lateral epicondylitis. We included (1) studies published between 2000 and 2015 and (2) studies with clearly defined surgical techniques...
April 12, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28411193/liver-metastasis-and-treatment-outcome-with-anti-pd-1-monoclonal-antibody-in-patients-with-melanoma-and-nsclc
#12
Paul C Tumeh, Matthew D Hellmann, Omid Hamid, Katy K Tsai, Kimberly L Loo, Matthew A Gubens, Michael Rosenblum, Christina L Harview, Janis Taube, Nathan Handley, Neharika Khurana, Adi Nosrati, Matthew F Krummel, Andrew Tucker, Eduardo Sosa, Philip J Sanchez, Nooriel Banayan, Juan Osorio, Dan L Nguyen-Kim, Jeremy Chang, I Peter Shintaku, Peter Boasberg, Emma J Taylor, Pamela N Munster, Alain P Algazi, Bartosz Chmielowski, Reinhard Dummer, Tristan R Grogan, David A Elashoff, Jimmy Hwang, Simone Goldinger, Edward Garon, Robert H Pierce, Adil I Daud
We explored the association between liver metastases, tumor CD8+ T cell count, and response in patients with melanoma or lung cancer treated with the anti-PD-1 antibody, pembrolizumab. The melanoma discovery cohort was drawn from the Phase I Keynote 001 trial, whereas the melanoma validation cohort was drawn from Keynote 002, 006, and EAP trials and the non-small cell lung cancer (NSCLC) cohort from Keynote 001. Liver metastasis was associated with reduced response and shortened progression-free survival (PFS); [objective response rate (ORR), 30...
April 14, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28411036/prolonged-particulate-chromate-exposure-does-not-inhibit-homologous-recombination-repair-in-north-atlantic-right-whale-eubalaena-glacialis-lung-cells
#13
Cynthia L Browning, Catherine F Wise, John Pierce Wise
Chromosome instability is a common feature of cancers that forms due to the misrepair of DNA double strand breaks. Homologous recombination (HR) repair is a high fidelity DNA repair pathway that utilizes a homologous DNA sequence to accurately repair such damage and protect the genome. Prolonged exposure (>72h) to the human lung carcinogen, particulate hexavalent chromium (Cr(VI)), inhibits HR repair, resulting in increased chromosome instability in human cells. Comparative studies have shown acute Cr(VI) exposure induces less chromosome damage in whale cells than human cells, suggesting investigating the effect of this carcinogen in other species may inform efforts to prevent Cr(VI)-induced chromosome instability...
April 11, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28410660/late-onset-alzheimer-disease
#14
REVIEW
Aimee L Pierce, Szofia S Bullain, Claudia H Kawas
The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease...
May 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28409801/single-mode-unidirectional-microcavity-laser
#15
Zhen-Nan Tian, Feng Yu, Yan-Hao Yu, Jun-Jie Xu, Qi-Dai Chen, Hong-Bo Sun
In this Letter, we report a suspended whispering gallery mode microdisk with a hole pierced through its surface. The novel disk is made up of Rhodamine B-doped resin, which is fabricated by femtosecond laser direct writing technology. The pierced microcavity achieves highly directional emission of single-mode lasing with a far field divergence angle of about 10 deg, and its high Q factor exceeds 2.6×10<sup>3</sup>. The excellent properties are confirmed by numerical simulation based on the finite-difference time-domain method...
April 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28409622/the-activation-of-pka-by-the-calcium-binding-protein-s100a1-is-independent-of-cyclic-amp
#16
Zephan Melville, Erick O Hernandez-Ochoa, Stephen J P Pratt, Yewei Liu, Adam D Pierce, Paul T Wilder, Kaylin A Adipietro, Daniel H Breysse, Krisin Varney, Martin F Schneider, David J Weber
Biochemical and structural studies demonstrate that S100A1 is involved in a Ca2+-dependent interaction with the type-2α and type-2β regulatory subunits of PKA (RIIα and RIIβ) to activate holo-PKA. The interaction was specific for S100A1 since other calcium-binding proteins (i.e. S100B, calmodulin) had no effect. Likewise, a role for S100A1 in PKA-dependent signaling was established since PKA-dependent subcellular redistribution of HDAC4 was abolished in cells derived from S100A1 knockout mice. Thus, the Ca2+-dependent interaction between S100A1 and the type-2 regulatory subunits represents a novel mechanism that provides a link between Ca2+- and PKA-signaling, which is important for the regulation of gene expression in skeletal muscle via HDAC4 cytosolic-nuclear trafficking...
April 14, 2017: Biochemistry
https://www.readbyqxmd.com/read/28409337/surgical-considerations-with-the-operative-fixation-of-unstable-paediatric-pelvic-ring-injuries
#17
Mohamed Kenawey
INTRODUCTION: The operative treatment of unstable pelvic injuries in paediatrics is not frequently indicated. The detailed modes of pelvic ring failure, surgical techniques, fixation choices, and peri-operative difficulties are not well reported. METHODS: From September 2010 to March 2016, 62 paediatric patients were admitted to an academic level I trauma center with the diagnosis of pelvic ring injury. Of them, 29 (17 males and 12 females) had operative fixation of unstable pelvic injuries...
April 13, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28409095/arthroscopic-piriformis-release-a-technique-for-sciatic-nerve-decompression
#18
Todd P Pierce, Casey M Pierce, Kimona Issa, Vincent K McInerney, Anthony Festa, Anthony J Scillia
Various techniques for piriformis muscle release have been published previously. However, it is imperative we continue to improve on existing techniques as well as develop new ones that may further optimize outcomes. Therefore, we aimed to describe an endoscopic technique for the release of the piriformis muscle in those with symptoms of sciatic nerve compression. Using the posterolateral portal, we are able to perform a complete release of the piriformis from the greater trochanter and the piriformis fossa with care to protect the external rotators and the sciatic nerve...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28408476/ogt-a-short-overview-of-an-enzyme-standing-out-from-usual-glycosyltransferases
#19
REVIEW
Moyira Aquino-Gil, Annick Pierce, Yobana Perez-Cervera, Edgar Zenteno, Tony Lefebvre
O-GlcNAcylation is a highly dynamic post-translational modification whose level depends on nutrient status. Only two enzymes regulate O-GlcNAcylation cycling, the glycosyltransferase OGT (O-GlcNAc transferase) and the glycoside hydrolase OGA (O-GlcNAcase), that add and remove the GlcNAc moiety to and from acceptor proteins, respectively. During the last 30 years, OGT has emerged as a master regulator of cell life with O-GlcNAcylation being found in viruses, bacteria, insects, protists and metazoans. The study of OGT in different biological systems opens new perspectives for understanding this enzyme in many kingdoms of life...
April 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28408082/injury-factors-associated-with-discharge-status-from-emergency-room-at-two-major-trauma-hospitals-in-the-gambia-africa
#20
REVIEW
Edrisa Sanyang, Corinne Peek-Asa, Paul Bass, Tracy L Young, Abubacarr Jagne, Baba Njie
INTRODUCTION: Injuries are the leading cause of disability across all ages and gender. In this study, we identified predictors of discharge status and disability at discharge among patients who seek emergency room treatment. MATERIALS AND METHODS: The study was conducted in two major trauma hospitals in urban Gambia. 1905 patients participated in the study. 74.9% were males, and 25.1% were females. The study includes injured patients from all mechanisms. However, patients' records without age, gender, injury mechanism, and deposition from the emergency room were considered incomplete and excluded...
April 5, 2017: Injury
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