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https://www.readbyqxmd.com/read/27905650/-aseptic-techniques-for-minor-surgical-procedures
#1
Marcela Concha-Rogazy, Catalina Andrighetti-Ferrada, Maximiliano Curi-Tuma
Aseptic techniques are those practices designed to reduce the risk of surgical site infection (SSI), defined as such, all those that occur within the first 30 days of the procedure. While the patient’s risk of developing an SSI in dermatologic surgery is low since many of the procedures are considered sterile, there are different factors associated with an increased or decreased risk of developing SSI. The characteristics of the surgical wound (such as involving infected or inflamed tissue or when breaks in the aseptic technique occur), patient characteristics (such as age, comorbidities, medication use and smoking) and procedure factors (such as setting, surgical technique, type of procedure, duration and body region involved)...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27899577/a-comprehensive-approach-to-expression-of-l1-loci
#2
Prescott Deininger, Maria E Morales, Travis B White, Melody Baddoo, Dale J Hedges, Geraldine Servant, Sudesh Srivastav, Madison E Smither, Monica Concha, Dawn L DeHaro, Erik K Flemington, Victoria P Belancio
L1 elements represent the only currently active, autonomous retrotransposon in the human genome, and they make major contributions to human genetic instability. The vast majority of the 500 000 L1 elements in the genome are defective, and only a relatively few can contribute to the retrotransposition process. However, there is currently no comprehensive approach to identify the specific loci that are actively transcribed separate from the excess of L1-related sequences that are co-transcribed within genes. We have developed RNA-Seq procedures, as well as a 1200 bp 5' RACE product coupled with PACBio sequencing that can identify the specific L1 loci that contribute most of the L1-related RNA reads...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898202/optimization-of-transcutaneous-vagus-nerve-stimulation-using-functional-mri
#3
Natalia Yakunina, Sam Soo Kim, Eui-Cheol Nam
OBJECTIVE/HYPOTHESIS: Vagus nerve stimulation (VNS) is an established therapy for drug-resistant epilepsy, depression, and a number of other disorders. Transcutaneous stimulation of the auricular branch of the vagus nerve (tVNS) has been considered as a non-invasive alternative. Several functional magnetic resonance imaging (fMRI) studies on the effects of tVNS used different stimulation parameters and locations in the ear, which makes it difficult to determine the optimal tVNS methodology...
November 29, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27889704/pharmacogenetic-studies-a-tool-to-improve-antidepressant-therapy
#4
Marta Ramos, Cecilia Berrogain, Julia Concha, Laura Lomba, Cristina Belén García, Mª Pilar Ribate
The World Health Organization (WHO) predicts that major depressive disorder (MDD) will be the second leading cause of death and disability by 2020. Nowadays, approximately 60-70% of patients with this disorder have shown the lack of effectiveness and tolerability of the therapy with antidepressants. The US Food and Drug Administration (FDA) and the European Medicine Agency (EMA) are including pharmacogenetic information in the labeling of several antidepressants. The presence of this information represents the relevance of genetic polymorphisms in drug response...
December 1, 2016: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/27889469/changes-in-neural-circuitry-associated-with-depression-at-pre-clinical-pre-motor-and-early-motor-phases-of-parkinson-s-disease
#5
REVIEW
Janina Borgonovo, Camilo Allende-Castro, Almudena Laliena, Néstor Guerrero, Hernán Silva, Miguel L Concha
Although Parkinson's Disease (PD) is mostly considered a motor disorder, it can present at early stages as a non-motor pathology. Among the non-motor clinical manifestations, depression shows a high prevalence and can be one of the first clinical signs to appear, even a decade before the onset of motor symptoms. Here, we review the evidence of early dysfunction in neural circuitry associated with depression in the context of PD, focusing on pre-clinical, pre-motor and early motor phases of the disease. In the pre-clinical phase, structural and functional changes in the substantia nigra, basal ganglia and limbic structures are already observed...
November 21, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27863637/nasal-septal-abscess-in-association-with-pediatric-acute-rhinosinusitis
#6
REVIEW
Duc A Tien, Paul Krakovitz, Samantha Anne
INTRODUCTION: Nasal septal abscess (NSA) in the pediatric population is rare and can result in devastating complications. Objective of this study is to review a case series of pediatric patients presenting with NSA in association with acute rhinosinusitis (ARS) for possible risk factors and predisposing conditions. METHOD: This is a retrospective review of pediatric patients that presented to a tertiary care hospital with nasal septal abscess associated with ARS...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27862234/interleukin-3-prevents-cellular-death-induced-by-oxidative-stres-in-hek293-cells
#7
Camila López, Patricia Zamorano, Stefanie Teuber, Mónica Salas, Carola Otth, María A Hidalgo, Ilona Concha, Angara Zambrano
Interleukin-3 (IL-3) is a well-characterized growth factor in hematopoietic cells, but it is also expressed in other cell types with poorly described functions. Many studies have provided evidence that IL-3 plays an important role in cell survival. We have previously shown that IL-3 is able to increase glucose uptake in HEK293 cells, suggesting that this factor requires sustained glucose metabolism to promote cell survival. In this study, we demonstrate that IL-3 contributes to cell survival under oxidative stress, a prominent feature in the pathophysiology of cancer, diabetes, and neurodegenerative diseases, as well as in the aging process...
November 10, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27861353/reconstruction-of-auricular-conchal-defects-with-local-flaps
#8
Ji Zhu, Hui Zhao, Kai Wu, Chuan Lv, Hong-da Bi, Meng-Yan Sun, Yu-Chong Wang, Xin Xing, Chun-Yu Xue
Reconstruction of the auricular conchal cavity is relatively difficult because of its unique structure, shape, and location. We compared different methods of repair of the auricular concha to determine the method that would cause the least injury to the donor site.The method selected was based on the location and size of the defect. If the defect was located in the upper part of the concha, or if the defect was >15 mm in diameter, we used a post-auricular subcutaneous pedicle island flap that was pulled through a post-auricular sulcus tunnel to cover the wound...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27847736/correlations-between-anatomic-variations-of-maxillary-sinus-ostium-and-postoperative-complication-after-sinus-lifting
#9
Jang Won Lee, Ji Yong Yoo, Seung Jae Paek, Won-Jong Park, Eun Joo Choi, Moon-Gi Choi, Kyung-Hwan Kwon
OBJECTIVES: The maxillary sinus mucosa is reported to recover to preoperative sterility after sinus floor elevation. However, when drainage of maxillary sinus is impaired, recovery can be delayed and maxillary sinusitis can occur. Therefore, in this study, we investigated the correlations between anatomic variants that can interrupt the ostium of the maxillary sinus and incidence of complication after sinus lifting. MATERIALS AND METHODS: The subjects are 81 patients who underwent sinus lifting in Wonkwang University Dental Hospital (Iksan, Korea)...
October 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/27834742/results-of-the-ictus-2-trial-intravascular-cooling-in-the-treatment-of-stroke-2
#10
Patrick Lyden, Thomas Hemmen, James Grotta, Karen Rapp, Karin Ernstrom, Teresa Rzesiewicz, Stephanie Parker, Mauricio Concha, Syed Hussain, Sachin Agarwal, Brett Meyer, Julie Jurf, Irfan Altafullah, Rema Raman
BACKGROUND AND PURPOSE: Therapeutic hypothermia is a potent neuroprotectant approved for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest. Therapeutic hypothermia for acute ischemic stroke is safe and feasible in pilot trials. We designed a study protocol to provide safer, faster therapeutic hypothermia in stroke patients. METHODS: Safety procedures and 4°C saline infusions for faster cooling were added to the ICTuS trial (Intravascular Cooling in the Treatment of Stroke) protocol...
November 10, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27834659/a-novel-chewing-detection-system-based-on-ppg-audio-and-accelerometry
#11
Vasileios Papapanagiotou, Christos Diou, Lingchuan Zhou, Janet van den Boer, Monica Mars, Anastasios Delopoulos
In the context of dietary management, accurate monitoring of eating habits is receiving increased attention. Wearable sensors, combined with the connectivity and processing of modern smart phones, can be used to robustly extract objective, and real-time measurements of human behaviour. In particular, for the task of chewing detection, several approaches based on an in-ear microphone can be found in the literature, while other types of sensors have also been reported, such as strain sensors. In this work, performed in the context of the SPLENDID project, we propose to combine an in-ear microphone with a photoplethysmography (PPG) sensor placed in the ear concha, in a new high accuracy and low sampling rate prototype chewing detection system...
November 4, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27832100/wiring-economy-of-pyramidal-cells-in-the-juvenile-rat-somatosensory-cortex
#12
Laura Anton-Sanchez, Concha Bielza, Pedro Larrañaga, Javier DeFelipe
Ever since Cajal hypothesized that the structure of neurons is designed in such a way as to save space, time and matter, numerous researchers have analyzed wiring properties at different scales of brain organization. Here we test the hypothesis that individual pyramidal cells, the most abundant type of neuron in the cerebral cortex, optimize brain connectivity in terms of wiring length. In this study, we analyze the neuronal wiring of complete basal arborizations of pyramidal neurons in layer II, III, IV, Va, Vb and VI of the hindlimb somatosensory cortical region of postnatal day 14 rats...
2016: PloS One
https://www.readbyqxmd.com/read/27821892/afrocolombian-ethnicity-a-paradoxical-protective-factor-against-dengue
#13
Jorge Humberto Rojas Palacios, Alberto Alzate, Héctor Jairo Martínez Romero, Alberto Ignacio Concha-Eastman
INTRODUCTION: Dengue is a priority public health problem. During epidemics in Cuba and Haiti, ethnic African descendant population had lower risk of dengue, and the ethnic factor was proposed as a protective one. OBJECTIVE: To determine the relation between the Dengue's cumulative incidence and the Afro-Colombian proportion in communities of Cali, during the epidemic of 2013. METHODS: This study was conducted in Cali, Colombia. The design was ecological, using information from the National Census 2005 projected to 2013, from the National Administrative Department of Statistics (DANE), and the National Epidemiological Surveillance System...
September 30, 2016: Colombia Médica: CM
https://www.readbyqxmd.com/read/27821531/nodal-signalling-and-asymmetry-of-the-nervous-system
#14
REVIEW
Iskra A Signore, Karina Palma, Miguel L Concha
The role of Nodal signalling in nervous system asymmetry is still poorly understood. Here, we review and discuss how asymmetric Nodal signalling controls the ontogeny of nervous system asymmetry using a comparative developmental perspective. A detailed analysis of asymmetry in ascidians and fishes reveals a critical context-dependency of Nodal function and emphasizes that bilaterally paired and midline-unpaired structures/organs behave as different entities. We propose a conceptual framework to dissect the developmental function of Nodal as asymmetry inducer and laterality modulator in the nervous system, which can be used to study other types of body and visceral organ asymmetries...
December 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27811822/a-new-species-of-symbiotic-palaemonid-shrimp-of-the-genus-pseudocoutierea-holthuis-1951-decapoda-caridea-palaemonidae-from-the-eastern-gulf-of-mexico-with-an-updated-key-for-the-identification-of-species-of-the-genus
#15
Gabriel E Ramos-Tafur, Rafael Lemaitre
A new species of symbiotic palaemonid shrimp of the genus Pseudocoutierea Holthuis, 1951, is described based on a specimen collected in the eastern Gulf of Mexico, off the southwest coast of Florida. Pseudocoutierea stephanieae sp. nov., is the seventh known in this genus, and morphologically most similar to P. antillensis Chace, 1972, and P. conchae Criales, 1981, from the western Atlantic, and P. elegans Holthuis, 1952, from the eastern Pacific, all sharing an expanded rostral base or eaves that terminate supra-distally in an acute tooth...
October 6, 2016: Zootaxa
https://www.readbyqxmd.com/read/27805046/natural-resistance-to-meningococcal-disease-related-to-cfh-loci-meta-analysis-of-genome-wide-association-studies
#16
Federico Martinón-Torres, Eileen Png, Chiea Chuen Khor, Sonia Davila, Victoria J Wright, Kar Seng Sim, Ana Vega, Laura Fachal, David Inwald, Simon Nadel, Enitan D Carrol, Nazareth Martinón-Torres, Sonia Marcos Alonso, Angel Carracedo, Elvira Morteruel, Julio López-Bayón, Andrés Concha Torre, Cristina Calvo Monge, Pilar Azcón González de Aguilar, Elisabeth Esteban Torné, María Del Carmen Martínez-Padilla, José María Martinón-Sánchez, Michael Levin, Martin L Hibberd, Antonio Salas
Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohorts: 897 cases and 5,613 controls; 4,898,259 SNPs)...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27766601/genetic-diversity-and-population-structure-of-rice-varieties-cultivated-in-temperate-regions
#17
Juan L Reig-Valiente, Juan Viruel, Ester Sales, Luis Marqués, Javier Terol, Marta Gut, Sophia Derdak, Manuel Talón, Concha Domingo
BACKGROUND: After its domestication, rice cultivation expanded from tropical regions towards northern latitudes with temperate climate in a progressive process to overcome limiting photoperiod and temperature conditions. This process has originated a wide range of diversity that can be regarded as a valuable resource for crop improvement. In general, current rice breeding programs have to deal with a lack of both germplasm accessions specifically adapted to local agro-environmental conditions and adapted donors carrying desired agronomical traits...
December 2016: Rice
https://www.readbyqxmd.com/read/27763976/transseptal-subperichondrial-endoscopic-hypophysectomy-with-preservation-of-vital-nasal-structures
#18
Hasmet Yazici, Sedat Doğan, Mehmet Akif Sönmez, Olcay Eser
INTRODUCTION: Pituitary surgery involving different techniques is often applied to the excision of benign adenomas. Operative interventions involved various approaches and techniques. Endoscopic transsphenoidal approach is the less traumatic route to the sella turcica, avoiding brain retraction, and also permitting good visualization, with lower rates of morbidity and mortality. Although mortality of pituitary surgery decreased by advances in surgical techniques morbidities such as synechiae formation, anosmia, bleeding, nasal septal perforations, drying, and incrustation due to traumatization of the nasal structures such as septum, nasal mucosa, and middle concha are the current problems in pituitary surgery...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27740763/candida-albicans-modifies-the-protein-composition-and-size-distribution-of-thp1-macrophages-derived-extracellular-vesicles
#19
Jose Antonio Reales-Calderón, Catarina Vaz, Lucía Monteoliva, Gloria Molero, Concha Gil
The effectiveness of macrophages in the response to systemic candidiasis is crucial to an effective clearance of the pathogen. The secretion of proteins, mRNAs, non-coding RNAs and lipids through extracellular vesicles (EVs) is one of the mechanisms of communication between immune cells. EVs change their cargo to mediate different responses, and may play a role in the response against infections. Thus, we have undertaken the first quantitative proteomic analysis on the protein composition of THP1 macrophages-derived EVs during the interaction with Candida albicans...
October 14, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27733859/physiological-basis-and-transcriptional-profiling-of-three-salt-tolerant-mutant-lines-of-rice
#20
Concha Domingo, Eric Lalanne, María M Catalá, Eva Pla, Juan L Reig-Valiente, Manuel Talón
Salinity is a complex trait that affects growth and productivity in many crops, including rice. Mutation induction, a useful tool to generate salt tolerant plants, enables the analysis of plants with similar genetic background, facilitating the understanding of the salt tolerance mechanisms. In this work, we generated three salt tolerant mutant lines by irradiation of a salt-sensitive cultivar plants and screened M2 plants at seedling stage in the presence of high salinity. These three lines, SaT20, SaS62, and SaT58, showed different responses to salinity, but exhibited similar phenotype to wild type plants, except SaT20 that displayed shorter height when grown in the absence of salt...
2016: Frontiers in Plant Science
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