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Chul Park, Jung Youl Park
BACKGROUND: The surgical correction of 'microtias with constricted ear features' has remained a challenge due to the variable shape and large volume of the remnant cartilage and skin involved. In order to clarify how this remnant cartilage and skin should be treated, we have reviewed and analyzed cases operated at our Center. METHODS: A total of 167 cases of Microtia with Constricted Ear Features, operated from 1992 to 2014, were included in the study. They were reviewed through medical records and photographs, analysis of surgical methods, and postoperative outcomes...
November 11, 2017: Plastic and Reconstructive Surgery
Briana Mezuk, Scott Ratliff, Jeannie B Concha, Cleopatra M Abdou, Jane Rafferty, Hedwig Lee, James S Jackson
Health-related behaviors, such as smoking, alcohol use, exercise, and diet, are major determinants of physical health and health disparities. However, a growing body of experimental research in humans and animals also suggests these behaviors can impact the ways our bodies respond to stress, such that they modulate (that is, serve as a means to self-regulate or cope with) the deleterious impact of stressful experiences on mental health. A handful of epidemiologic studies have investigated the intersection between stress and health behaviors on health disparities (both mental and physical), with mixed results...
December 2017: SSM—Population Health
Galileo A Gonzalez-Conchas, Laura Rodriguez-Romo, David Hernandez-Barajas, Juan F Gonzalez-Guerrero, Ivan A Rodriguez-Fernandez, Adrian Verdines-Perez, Arnoud J Templeton, Alberto Ocana, Bostjan Seruga, Ian F Tannock, Eitan Amir, Francisco E Vera-Badillo
BACKGROUND: The epidermal growth factor receptor (EGFR) is a member of the ErbB family of membrane tyrosine-kinase receptors. Studies exploring the prognostic role of EGFR-overexpression in early breast cancer have shown variable results, and the true prognostic value of EGFR is unknown. METHODS: A systematic review of identified publications exploring the association between EGFR-overexpression (as defined from different techniques and cut-offs) and outcomes [disease-free (DFS) and, overall survival (OS)] in women with early breast cancer...
October 31, 2017: Cancer Treatment Reviews
Eiji Yanagisawa, Dewey A Christmas, Joseph P Mirante
No abstract text is available yet for this article.
October 2017: Ear, Nose, & Throat Journal
Ángeles Domínguez-Soto, Alicia Usategui, Mateo de Las Casas-Engel, Miriam Simón-Fuentes, Concha Nieto, Víctor D Cuevas, Miguel A Vega, José Luis Pablos, Ángel L Corbí
Peripheral serotonin (5-hydroxytryptamine, 5-HT) regulates cell growth and differentiation in numerous cell types through engagement of seven types of cell surface receptors (HTR1-7). Deregulated 5-HT/HTR levels contribute to pathology in chronic inflammatory diseases, with macrophages being relevant targets for the physio-pathological effects of 5-HT. In fact, 5-HT skews human macrophage polarization through engagement of 5-HT2BR and 5-HT7R receptors. We now report that 5-HT primes macrophages for reduced pro-inflammatory cytokine production and IFN type I-mediated signaling, and promotes an anti-inflammatory and pro-fibrotic gene signature in human macrophages...
November 7, 2017: Scientific Reports
Josef Symon S Concha, Joseph F Merola, David Fiorentino, Victoria P Werth
Mechanic's hands is a poorly defined clinical finding that has been reported in a variety of rheumatologic diseases. Morphologic descriptions include hyperkeratosis on the sides of the digits that sometimes extends to the distal tips, diffuse palmar scale, and, more recently observed, linear discrete scaly papules in a similar lateral distribution. The association of mechanic's hands with dermatomyositis, although recognized, is still debatable. In this review, most studies have shown that mechanic's hands is commonly associated with dermatomyositis and displays histopathologic findings of interface dermatitis, colloid bodies and interstitial mucin which are consistent with a cutaneous connective tissue disease...
November 1, 2017: Journal of the American Academy of Dermatology
Mahmut Özkiriş, Zeliha Kapusuz Gencer, Levent Saydam
BACKGROUND: In this study, the authors compared the right and left olfactory bulb volumes by magnetic resonance image findings of patients with unilateral concha bullosa (CB). METHODS: The cranial magnetic resonance imaging studies of 24 patients having unilateral CB were reviewed. There were 10 males and 14 females ranging in age from 29 to 51 years (mean age, 29 ± 15.2 years). The volumes of both olfactory bulbs (contralateral and ipsilateral to the concha bullosa side) were calculated by using the computer program...
October 27, 2017: Journal of Craniofacial Surgery
M Damar, A E Dinç, D Erdem, S Bişkin, S Ş Eliçora, Y Ç Kumbul
OBJECTIVE: This objective of this study is to evaluate the presence and the coincidence of common nasal and paranasal sinus pathologies in adults suffering from chronic otitis media (COM) and its subtypes. MATERIALS AND METHODS: The study group comprised 354 ears of 177 patients who underwent tympanoplasty with or without mastoidectomy from January 2013 to February 2015 due to uni/bilateral COM. Chronic suppurative otitis media, intratympanic tympanosclerosis (ITTS), cholesteatoma, and tympanic membrane with retraction pockets constituted subtypes of COM...
September 2017: Nigerian Journal of Clinical Practice
Francisco Sahli Costabal, Felipe A Concha, Daniel E Hurtado, Ellen Kuhl
In the past years, a number cardiac electromechanics models have been developed to better understand the excitation-contraction behavior of the heart. However, there is no agreement on whether inertial forces play a role in this system. In this study, we assess the influence of mass in electromechanical simulations, using a fully coupled finite element model. We include the effect of mechano-electrical feedback via stretch activated currents. We compare five different models: electrophysiology, electromechanics, electromechanics with mechano-electrical feedback, electromechanics with mass, and electromechanics with mass and mechano-electrical feedback...
June 15, 2017: Computer Methods in Applied Mechanics and Engineering
L Li, J Xie, Y Liu, S S Gong
Objective: To analyze the risk factors of failure to dry ear after radical mastoidectomy and discuss key points in revisonal surgery. Methods: Clinical data of 25 patients(32 ears) with revisonal mastoidectomy were analyzed. The preoperative temporal bone CT findings, intra-operative findings, surgical procedures, postoperative operating cavities and aural abilities were recorded and analyzed. Results: All patients received preoperative temporal bone CT followed by revisonal radical mastoidectomy under microscope and general anesthesia...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Manuel Pool-Chalé, Ivón Ramírez-Morillo, Germán Carnevali Fernández-Concha, Claudia T Hornung-Leoni
Individuals of Aechmea bracteata show inflorescences with red scape bracts and odorless, yellow, tubular, diurnal flowers, with closely-arranged sexual organs, producing a large amount of fruits. In order to investigate the reproductive system of this species, a suite of characters were assessed: phenology, floral morphology and biology, nectar production dynamics, and fruit and seed production and germination, as a result of controlled pollination crosses. The study was conducted during two flowering seasons in wild populations in Yucatán, Mexico...
October 13, 2017: Plant Biology
Guishan Zhang, Mohamed Fauzi Haroon, Ruifu Zhang, Xiaoyan Dong, Dandan Wang, Yunpeng Liu, Weibing Xun, Xiuzhu Dong, Ulrich Stingl
Two moderately halophilic marine bacterial strains of the family Rhodobacteraceae, designated ZGT108(T) and ZGT118(T), were isolated from the brine-seawater interface at Erba Deep in the Red Sea (Saudi Arabia). Cells of both strains were aerobic, rod-shaped, non-motile, and Gram-stain-negative. The sequence similarity of the 16S rRNA genes of strains ZGT108(T) and ZGT118(T) was 94.9 %. The highest 16S rRNA gene sequence similarity of strain ZGT108(T) to its closest relative, Ruegeria conchae JCM 17315(T), was 98...
October 12, 2017: International Journal of Systematic and Evolutionary Microbiology
Jesus Ruiz, Paula Ramirez, María José Company, Mónica Gordon, Esther Villarreal, Pablo Concha, María Aroca, Juan Frasquet, María Remedios Marqués, Álvaro Castellanos-Ortega
OBJECTIVE: To evaluate the association between pharmacokinetic and pharmacodynamic ratio and treatment response to amikacin in critically ill patients. MATERIAL AND METHODS: An observational prospective study was designed. Critically ill adult patients with an infection due to amikacin-sensitive gram-negative bacteria treated with amikacin were included. Amikacin maximum (Cmax) and minimum (Cmin) concentration samples were taken during the first 48h and 96h after the beginning of the treatment...
October 7, 2017: Journal of Global Antimicrobial Resistance
Brian G Lawhorn, Tritin Tran, Victor S Hong, Lisa A Morgan, BaoChau T Le, Mark R Harpel, Larry Jolivette, Elsie Diaz, Benjamin Schwartz, Jeffrey W Gross, Thaddeus Tomaszek, Simon Semus, Nestor Concha, Angela Smallwood, Dennis A Holt, Lara S Kallander
Discovery of potent renin inhibitors which contain a simplified alkylamino Asp-binding group and exhibit improved selectivity for renin over Cyp3A4 is described. Structure-function results in this series are rationalized based on analysis of selected compounds bound to renin, and the contribution of each molecular feature leading to the reduced P450 inhibition is quantified.
September 23, 2017: Bioorganic & Medicinal Chemistry Letters
Luis Concha-Marambio, Paula Maldonado, Rosalba Lagos, Octavio Monasterio, Felipe Montecinos-Franjola
Cytokinesis is the last stage in the cell cycle. In prokaryotes, the protein FtsZ guides cell constriction by assembling into a contractile ring-shaped structure termed the Z-ring. Constriction of the Z-ring is driven by the GTPase activity of FtsZ that overcomes the energetic barrier between two protein conformations having different propensities to assemble into polymers. FtsZ is found in psychrophilic, mesophilic and thermophilic organisms thereby functioning at temperatures ranging from subzero to >100°C...
2017: PloS One
Jesse Mu, Kallol R Chaudhuri, Concha Bielza, Jesus de Pedro-Cuesta, Pedro Larrañaga, Pablo Martinez-Martin
Parkinson's disease is now considered a complex, multi-peptide, central, and peripheral nervous system disorder with considerable clinical heterogeneity. Non-motor symptoms play a key role in the trajectory of Parkinson's disease, from prodromal premotor to end stages. To understand the clinical heterogeneity of Parkinson's disease, this study used cluster analysis to search for subtypes from a large, multi-center, international, and well-characterized cohort of Parkinson's disease patients across all motor stages, using a combination of cardinal motor features (bradykinesia, rigidity, tremor, axial signs) and, for the first time, specific validated rater-based non-motor symptom scales...
2017: Frontiers in Aging Neuroscience
Concha Tojo, David Buceta, M Arturo López-Quintela
Computer simulations were carried out to study the origin of the different metal segregation showed by bimetallic nanoparticles synthesized in microemulsions. Our hypothesis is that the kinetics of nanoparticle formation in microemulsions has to be considered on terms of two potentially limiting factors, chemical reaction itself and the rate of reactants exchange between micelles. From the kinetic study it is deduced that chemical reduction in microemulsions is a pseudo first-order process, but not from the beginning...
January 15, 2018: Journal of Colloid and Interface Science
Ming-Ying Wu, Chun-Bing Chen, Yi-Hsi Chen, Catherine Chang, Kai-Chieh Chan
OBJECTIVES/HYPOTHESIS: Pseudocyst of the auricle is a benign, noninflammatory cystic disease that is more common in Asians than in Caucasians. When managed conservatively, the results are often unsatisfactory and recurrences are common. We aimed to introduce a novel modified surgical method that involves a deroofing technique followed by a sandwich compression suture using two rubber tourniquet sheets and an iodine-soaked cotton ball for the treatment of auricular pseudocysts and to ascertain its effectiveness...
September 20, 2017: Laryngoscope
Kaare B Mikkelsen, David Bové Villadsen, Marit Otto, Preben Kidmose
BACKGROUND: Sleep and sleep quality assessment by means of sleep stage analysis is important for both scientific and clinical applications. Unfortunately, the presently preferred method, polysomnography (PSG), requires considerable expert assistance and significantly affects the sleep of the person under observation. A reliable, accurate and mobile alternative to the PSG would make sleep information much more readily available in a wide range of medical circumstances. NEW METHOD: Using an already proven method, ear-EEG, in which electrodes are placed inside the concha and ear canal, we measure cerebral activity and automatically score the sleep into up to five stages...
September 19, 2017: Biomedical Engineering Online
Anyi Mazo-Vargas, Carolina Concha, Luca Livraghi, Darli Massardo, Richard W R Wallbank, Linlin Zhang, Joseph D Papador, Daniel Martinez-Najera, Chris D Jiggins, Marcus R Kronforst, Casper J Breuker, Robert D Reed, Nipam H Patel, W Owen McMillan, Arnaud Martin
Butterfly wing patterns provide a rich comparative framework to study how morphological complexity develops and evolves. Here we used CRISPR/Cas9 somatic mutagenesis to test a patterning role for WntA, a signaling ligand gene previously identified as a hotspot of shape-tuning alleles involved in wing mimicry. We show that WntA loss-of-function causes multiple modifications of pattern elements in seven nymphalid butterfly species. In three butterflies with a conserved wing-pattern arrangement, WntA is necessary for the induction of stripe-like patterns known as symmetry systems and acquired a novel eyespot activator role specific to Vanessa forewings...
October 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
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