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Linea Melchior, Astrid Hirschmann, Paul Hofman, Christophe Bontoux, Angel Concha, Salima Mrabet-Dahbi, Pascal Vannuffel, Emmanuel Watkin, Martina Putzová, Stefania Scarpino, Anne Cayre, Paloma Martin, Robert Stoehr, Arndt Hartmann
No abstract text is available yet for this article.
April 19, 2024: Virchows Archiv: An International Journal of Pathology
#2
REVIEW
Miguel Martín, Atanasio Pandiella, Emilio Vargas-Castrillón, Elena Díaz-Rodríguez, Teresa Iglesias-Hernangómez, Concha Martínez Cano, Inés Fernández-Cuesta, Elena Winkow, Maria Francesca Perelló
Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) consisting of a humanised, anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody covalently linked to a topoisomerase I inhibitor cytotoxic payload (DXd). The high drug-to-antibody ratio (8:1) ensures a high DXd concentration is delivered to target tumour cells, following internalisation of T-DXd and subsequent cleavage of its tetrapeptide-based linker. DXd's membrane-permeable nature enables it to cross cell membranes and potentially exert antitumour activity on surrounding tumour cells regardless of HER2 expression...
April 13, 2024: Critical Reviews in Oncology/hematology
#3
JOURNAL ARTICLE
Jhonny Acevedo Ayala, Andrea Solari Del Sol, Magdalena Arroyo Concha, Dominique Tirreau Román
Chile is facing an increasingly aging population and, with it, changes in its demographic, epidemiological, and healthcare structure. As a result, the sexual health of the elderly is an emerging area at the social level and in healthcare systems. This research aims to identify general aspects of sexuality in the elderly and learn about educational content delivered to this group using digital technologies. To do this, we proposed a review of scientific literature on the subject between January 1st, 2018, and December 31st, 2022, in the databases Web of Science, MEDLINE/PubMed, LILACS, Cochrane, Scopus, and Google Scholar...
April 15, 2024: Medwave
#4
REVIEW
Vinícius Caldeira Quintão, Mario Concha, Lina Andrea Sarmiento Argüello, Silvana Cavallieri, Luis I Cortinez, Gabriel Soares de Sousa, Marcella Marino Malavazzi Clemente, Ricardo Vieira Carlos, Juan Manuel Rodríguez, Karla Gutiérrez, Denis H Jablonka, Annery G García-Marcinkiewicz
BACKGROUND: Latin America comprises an extensive and diverse territory composed of 33 countries in the Caribbean, Central, and South America where Romance languages-languages derived from Latin are predominantly spoken. Economic disparities exist, with inequitable access to pediatric surgical care. The Latin American Surgical Outcomes Study in Pediatrics (LASOS-Peds), a multi-national collaboration, will determine safety of pediatric anesthesia and perioperative care. OBJECTIVE: Below, we provide a descriptive initiative to share how pediatric anesthesia in Brazil, Chile, and Mexico operate...
April 15, 2024: Paediatric Anaesthesia
#5
JOURNAL ARTICLE
Jose Luis Trevino Gonzalez, Aldo Sergio Fuentes Torres, Josefina Alejandra Morales Del Angel
Background and aim Nasal obstruction is one of the most common reasons for consultation addressed by otolaryngologists. There are anatomical, physiological, and pathological etiologies. Sometimes the treatment can become a challenge for the specialist, so a detailed evaluation of the etiologies must be carried out. The involvement of the nasal vestibular body (NVB) in obstructive symptoms has been described. Therefore, we must be familiar with its anatomy, presentation, and contribution to this symptomatology...
March 2024: Curēus
#6
JOURNAL ARTICLE
Miguel Alarcón-Rivera, Carolina Cornejo-Mella, Camila Cáceres-Aravena, Yeny Concha-Cisternas, Paz Fernández-Valero, Eduardo Guzmán-Muñoz
This study aimed to establish the relationship between the appendicular muscle mass index (AMMI), assessed from anthropometric variables, and the physical function of older people. Seventy-six older people participated in this study (72.03 ± 7.03 years). The participants underwent evaluations to determine their AMMI using anthropometry (weight, calf circumference, hip circumference, and knee height) and manual grip strength. Additionally, their physical function was evaluated using the 5-chair stand test, the 3-meter walk test, and the timed up and go test (TUG) to determine the strength of the lower limbs, the gait speed, and the dynamic balance, respectively...
2024: AIMS Public Health
#7
JOURNAL ARTICLE
Brenda M Ipinza-Concha, Luciano Dibona-Villanueva, Denis Fuentealba, Alexander Pinilla-Quispe, Daniel Schwantes, María A Garzón-Nivia, Mario A Herrera-Défaz, Héctor A Valdés-Gómez
Penicillium digitatum is the causal agent of green mold, a primary postharvest disease of citrus fruits. This study evaluated the efficacy of a novel photoactive chitosan-riboflavin bioconjugate (CH-RF) to control green mold in vitro and in lemon fruit. The results showed total inhibition of P. digitatum growth on APDA supplemented with CH-RF at 0.5% ( w / v ) and a significant reduction of 84.8% at 0.25% ( w / v ). Lemons treated with CH-RF and kept under controlled conditions (20 °C and 90-95% relative humidity) exhibited a noteworthy reduction in green mold incidence four days post-inoculation...
March 23, 2024: Polymers
#8
JOURNAL ARTICLE
Ke Xie, Jessica Royer, Sara Larivière, Raul Rodriguez-Cruces, Stefan Frässle, Donna Gift Cabalo, Alexander Ngo, Jordan DeKraker, Hans Auer, Shahin Tavakol, Yifei Weng, Chifaou Abdallah, Thaera Arafat, Linda Horwood, Birgit Frauscher, Lorenzo Caciagli, Andrea Bernasconi, Neda Bernasconi, Zhiqiang Zhang, Luis Concha, Boris C Bernhardt
Temporal lobe epilepsy (TLE) is the most common pharmaco-resistant epilepsy in adults. While primarily associated with mesiotemporal pathology, recent evidence suggests that brain alterations in TLE extend beyond the paralimbic epicenter and impact macroscale function and cognitive functions, particularly memory. Using connectome-wide manifold learning and generative models of effective connectivity, we examined functional topography and directional signal flow patterns between large-scale neural circuits in TLE at rest...
April 9, 2024: Progress in Neurobiology
#9
JOURNAL ARTICLE
Gansheng Tan, Josh Adams, Kara Donovan, Phillip Demarest, Jon T Willie, Peter Brunner, Jenna L Gorlewicz, Eric C Leuthardt
BACKGROUND: Working memory is essential to a wide range of cognitive functions and activities. Transcutaneous auricular VNS (taVNS) is a promising method to improve working memory performance. However, the feasibility and scalability of electrical stimulation are constrained by several limitations, such as auricular discomfort and inconsistent electrical contact. OBJECTIVE: We aimed to develop a novel and practical method, vibrotactile taVNS, to improve working memory...
April 7, 2024: Brain Stimulation
#10
JOURNAL ARTICLE
Brandon F Keele, Afam A Okoye, Christine M Fennessey, Benjamin Varco-Merth, Taina T Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P Davenport, Jeffrey D Lifson, Louis J Picker
The rebound competent viral reservoir (RCVR)-virus that persists during antiretroviral treatment (ART) and can reignite systemic infection when treatment is stopped-is the primary barrier to eradicating HIV. We used time to initiation of ART during primary infection of rhesus macaques (RMs) after intravenous challenge with barcoded SIVmac239 as a means to elucidate the dynamics of RCVR establishment in groups of RMs by creating a multi-log range of pre-ART viral loads and then assessed viral time-to-rebound and reactivation rates resulting from the discontinuation of ART after one year...
April 2024: PLoS Pathogens
#11
Gansheng Tan, Josh Adams, Kara Donovan, Phillip Demarest, Jon T Willie, Peter Brunner, Jenna L Gorlewicz, Eric C Leuthardt
BACKGROUND: Working memory is essential to a wide range of cognitive functions and activities. Transcutaneous auricular VNS (taVNS) is a promising method to improve working memory performance. However, the feasibility and scalability of electrical stimulation are constrained by several limitations, such as auricular discomfort and inconsistent electrical contact. OBJECTIVE: We aimed to develop a novel and practical method, vibrotactile taVNS, to improve working memory...
March 27, 2024: bioRxiv
#12
JOURNAL ARTICLE
Estefanía Concha-Graña, Carmen M Moscoso-Pérez, Verónica Fernández-González, Purificación López-Mahía, Soledad Muniategui-Lorenzo
BACKGROUND: Many of the chemicals frequently used as additives have been recognised as hazardous substances, and therefore their analysis is necessary to evaluate plastic contamination risk. Additives analysis in plastic samples is usually performed by methods involving high volumes of toxic solvents or having high detection limits. In this work, a novel, fast, solventless and reliable green method was developed for the automated analysis of plastic additives from plastic samples. The proposed method consists of in-tube extraction dynamic headspace sampling (ITEX-DHS) combined with gas chromatography (GC) and mass spectrometry (MS/MS) determination...
May 8, 2024: Analytica Chimica Acta
#13
JOURNAL ARTICLE
Yiwen Deng, Haiyue Jiang, Bo Pan, Xiaobo Yu
BACKGROUND: The presence of polyotia in individuals with microtia is a rare deformity. Due to the intricate structure of the auricle, uncertain etiology, and challenging corrective techniques, it has always been a focal point in the field of plastic surgery. The present study presents a technique for correcting the combination of polyotia and microtia by utilizing residual ear tissue as graft material. METHODS: The retrospective study included 23 patients with polyotia and microtia from 2018 to 2022...
March 21, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
#14
JOURNAL ARTICLE
R J Molenaar, R Dijkman, I Jorna, J J de Wita
Infectious bronchitis virus (IBV) strains of genotype GVIII have been emerging in Europe in the last decade, but no biological characterisation has been reported so far. This paper reports the extensive genetic and biological characterization of IBV strain D2860 of genotype GVIII that was isolated from a Dutch layer flock that showed a drop in egg production. Whole genome sequencing showed that it has a high similarity (95%) to CK/DE/IB80/2016 (commonly known as IB80). Cross-neutralization tests with antigens and serotype-specific antisera of a panel different non-GVIII genotypes consistently gave less than 2% antigenic cross-relationship with D2860...
April 4, 2024: Avian Pathology: Journal of the W.V.P.A
#15
JOURNAL ARTICLE
Marivi Verdeguer Gómez, Concha Llopis Tortosa, Miguel Murcia Soler, Joan Paredes Carbonell, José Manuel Soler Torro, Carlos Herrero Gil
AIM: Evaluate the effectiveness of an intervention to incorporate group and community activities on a sustained basis in all the Basic Health Zones (ZBS) of a health area. DESIGN: During January and February 2019, two members of the research team traveled to each ZBS to interview the medical and nursing coordinators who had previously received an ad hoc initial assessment questionnaire (QAI) by email. PLACE: The scope is the 11 ZBS of a health area...
April 2, 2024: Atencion Primaria
#16
JOURNAL ARTICLE
P W Crous, E R Osieck, R G Shivas, Y P Tan, S L Bishop-Hurley, F Esteve-Raventós, E Larsson, J J Luangsa-Ard, F Pancorbo, S Balashov, I G Baseia, T Boekhout, S Chandranayaka, D A Cowan, R H S F Cruz, P Czachura, S De la Peña-Lastra, F Dovana, B Drury, J Fell, A Flakus, R Fotedar, Ž Jurjević, A Kolecka, J Mack, G Maggs-Kölling, S Mahadevakumar, A Mateos, S Mongkolsamrit, W Noisripoom, M Plaza, D P Overy, M Piątek, M Sandoval-Denis, J Vauras, M J Wingfield, S E Abell, A Ahmadpour, A Akulov, F Alavi, Z Alavi, A Altés, P Alvarado, G Anand, N Ashtekar, B Assyov, G Banc-Prandi, K D Barbosa, G G Barreto, J-M Bellanger, J L Bezerra, D J Bhat, P Bilański, T Bose, F Bozok, J Chaves, D H Costa-Rezende, C Danteswari, V Darmostuk, G Delgado, S Denman, A Eichmeier, J Etayo, G Eyssartier, S Faulwetter, K G G Ganga, Y Ghosta, J Goh, J S Góis, D Gramaje, L Granit, M Groenewald, G Gulden, L F P Gusmão, A Hammerbacher, Z Heidarian, N Hywel-Jones, R Jankowiak, M Kaliyaperumal, O Kaygusuz, K Kezo, A Khonsanit, S Kumar, C H Kuo, T Læssøe, K P D Latha, M Loizides, S M Luo, J G Maciá-Vicente, P Manimohan, P A S Marbach, P Marinho, T S Marney, G Marques, M P Martín, A N Miller, F Mondello, G Moreno, K T Mufeeda, H Y Mun, T Nau, T Nkomo, A Okrasińska, J P A F Oliveira, R L Oliveira, D A Ortiz, J Pawłowska, M À Pérez-De-Gregorio, A R Podile, A Portugal, N Privitera, K C Rajeshkumar, I Rauf, B Rian, A Rigueiro-Rodríguez, G F Rivas-Torres, P Rodriguez-Flakus, M Romero-Gordillo, I Saar, M Saba, C D Santos, P V S R N Sarma, J L Siquier, S Sleiman, M Spetik, K R Sridhar, M Stryjak-Bogacka, K Szczepańska, H Taşkın, D S Tennakoon, D Thanakitpipattana, J Trovão, I Türkekul, A L van Iperen, P van 't Hof, G Vasquez, C M Visagie, B D Wingfield, P T W Wong, W X Yang, M Yarar, O Yarden, N Yilmaz, N Zhang, Y N Zhu, J Z Groenewald
Novel species of fungi described in this study include those from various countries as follows: Australia , Aschersonia mackerrasiae on whitefly, Cladosporium corticola on bark of Melaleuca quinquenervia , Penicillium nudgee from soil under Melaleuca quinquenervia , Pseudocercospora blackwoodiae on leaf spot of Persoonia falcata , and Pseudocercospora dalyelliae on leaf spot of Senna alata . Bolivia , Aspicilia lutzoniana on fully submersed siliceous schist in high-mountain streams, and Niesslia parviseta on the lower part and apothecial discs of Erioderma barbellatum on a twig...
June 2023: Persoonia
#17
JOURNAL ARTICLE
Mostafa Ismail, Balegh Abdelhak, Khalaf Hamead, Radwa A Ebraheem, Rasha A Abdelmoneim
Pneumatized middle turbinate (Concha bullosa) is one of the commonest intranasal anatomical variants. Surgery is the effective method to control symptomatic concha bullosa, however, still no clear definition for the best surgical technique. The aim of our study to assess and compare the short-term outcomes of crushing and lateral laminectomy with and without mucosal preservation in the surgical treatment of symptomatic concha bullosa. Thirty patients who underwent concha bullosa surgery (a total of 42 conchae surgeries) were included in this prospective randomized study...
April 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
#18
JOURNAL ARTICLE
Faezeh Kashi, Zahra Dalili Kajan, Soophia Yaghoobi, Negar Khosravifard
This study assessed the frequency of accessory maxillary ostium (AMO) in patients with/without sinusitis and its correlation with anatomical variations using cone-beam computed tomography (CBCT). In this cross-sectional study, 244 CBCT scans were evaluated in two groups: with maxillary sinusitis having > 2 mm mucosal thickening and without max sinusitis as a normal group having normal or less than 2 mm mucosa. The CBCT scans of each group were carefully evaluated for the presence/absence of AMO, patency/obstruction of the primary maxillary ostium (PMO), and the presence of anatomical variations of the paranasal sinuses...
April 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
#19
JOURNAL ARTICLE
Anibal A Concha-Meyer, Alexandra González-Esparza, Patrick J Cullen, Felipe Veloso, Mario Favre, Julio C Valenzuela, Lorena Toloza, Brendan A Niemira
Fresh blueberries are delicate, hand-picked, packaged, and refrigerated fruits vulnerable to spoilage and contamination. Cold atmospheric plasma (CAP) is a promising antimicrobial technology; therefore, this study evaluated the CAP treatment effect on acid-tolerant Listeria innocua and Listeria monocytogenes and evaluated changes in the quality of the treated fruit. Samples were spot-inoculated with pH 5.5 and 6.0 acid-adapted Listeria species. Samples were treated with gliding arc CAP for 15, 30, 45, and 60 s and evaluated after 0, 1, 4, 7, and 11 days of storage at 4 °C and 90% humidity for the following quality parameters: total aerobic counts, yeast and molds, texture, color, soluble solids, pH, and titratable acidity...
March 7, 2024: Foods (Basel, Switzerland)
#20
JOURNAL ARTICLE
Estela Sangüesa, Emilio Fernández-Egea, Julia Concha, Cristina B García, María Pilar Ribate
Managing schizophrenia with clozapine poses a significant challenge due to prevalent therapeutic failures. The increasing interest in personalized medicine underscores the importance of integrating pharmacogenetic information for effective pharmacotherapeutic monitoring in patients. The objective of this study was to explore the correlation between DRD2 , HTR2A , SLC6A4 , CYP1A2 , and ABCB1 polymorphisms and clozapine response in 100 patients with Treatment-Resistant Schizophrenia. Different scales such as the Positive and Negative Syndrome Scale (PANSS), the Warwick-Edinburgh Mental Wellbeing Scale (SWEMWBS), the Global Assessment of Functioning Scale (GAF), the Brief Negative Symptom Scale (BNSS), and pharmacokinetic parameters were used to analyse the efficacy of the treatment...
March 7, 2024: Biomedicines
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