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https://www.readbyqxmd.com/read/28927417/automatic-sleep-staging-using-ear-eeg
#1
Kaare B Mikkelsen, David Bové Villadsen, Marit Otto, Preben Kidmose
BACKGROUND: Sleep and sleep quality assessment by means of sleep stage analysis is important for both scientific and clinical applications. Unfortunately, the presently preferred method, polysomnography (PSG), requires considerable expert assistance and significantly affects the sleep of the person under observation. A reliable, accurate and mobile alternative to the PSG would make sleep information much more readily available in a wide range of medical circumstances. NEW METHOD: Using an already proven method, ear-EEG, in which electrodes are placed inside the concha and ear canal, we measure cerebral activity and automatically score the sleep into up to five stages...
September 19, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28923954/macroevolutionary-shifts-of-wnta-function-potentiate-butterfly-wing-pattern-diversity
#2
Anyi Mazo-Vargas, Carolina Concha, Luca Livraghi, Darli Massardo, Richard W R Wallbank, Linlin Zhang, Joseph D Papador, Daniel Martinez-Najera, Chris D Jiggins, Marcus R Kronforst, Casper J Breuker, Robert D Reed, Nipam H Patel, W Owen McMillan, Arnaud Martin
Butterfly wing patterns provide a rich comparative framework to study how morphological complexity develops and evolves. Here we used CRISPR/Cas9 somatic mutagenesis to test a patterning role for WntA, a signaling ligand gene previously identified as a hotspot of shape-tuning alleles involved in wing mimicry. We show that WntA loss-of-function causes multiple modifications of pattern elements in seven nymphalid butterfly species. In three butterflies with a conserved wing-pattern arrangement, WntA is necessary for the induction of stripe-like patterns known as symmetry systems and acquired a novel eyespot activator role specific to Vanessa forewings...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28904066/pd-1-status-in-cd8-t-cells-associates-with-survival-and-anti-pd-1-therapeutic-outcomes-in-head-and-neck-cancer
#3
Benjamin A Kansy, Fernando Concha-Benavente, Raghvendra M Srivastava, Hyun-Bae Jie, Gulidanna Shayan, Yu Lei, Jessica Moskovitz, Jennifer Moy, Jing Li, Sven Brandau, Stephan Lang, Nicole C Schmitt, Gordon J Freeman, William E Gooding, David A Clump, Robert L Ferris
Improved understanding of expression of immune checkpoint receptors (ICR) on tumor-infiltrating lymphocytes (TIL) may facilitate more effective immunotherapy in head and neck cancer (HNC) patients. A higher frequency of PD-1(+) TIL has been reported in human papillomavirus (HPV)(+) HNC patients, despite the role of PD-1 in T cell exhaustion. This discordance led us to hypothesize that the extent of PD-1 expression more accurately defines T cell function and prognostic impact, since PD-1(high) T cells may be more exhausted than PD-1(low) T cells and may influence clinical outcome and response to anti-PD-1 immunotherapy...
September 13, 2017: Cancer Research
https://www.readbyqxmd.com/read/28900866/progressive-multifocal-leukoencephalopathy-11%C3%A2-years-after-liver-transplantation-a-case-report
#4
Ana Moreno-Estébanez, Javier Almeida Velasco, Tomás Pérez-Concha, Tirso González-Pinto, Iñigo Gabilondo
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the central nervous system caused by JC virus. Only ten cases of PML have been reported so far in liver transplant recipients. We present a case of liver posttransplantation PML with characteristic clinical and brain MRI findings, but with an atypical late onset, developed 11 years after transplantation and after single-drug, long-term (8 years), and low-dose (750 mg twice a day) immunosuppression with mycophenolate mofetil (MMF)...
September 12, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28879169/herpes-simplex-virus-type-1-neuronal-infection-perturbs-golgi-apparatus-integrity-through-activation-of-src-tyrosine-kinase-and-dyn-2-gtpase
#5
Carolina Martin, Luis Leyton, Melissa Hott, Yennyfer Arancibia, Carlos Spichiger, Mark A McNiven, Felipe A Court, Margarita I Concha, Patricia V Burgos, Carola Otth
Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen that establishes a latent persistent neuronal infection in humans. The pathogenic effects of repeated viral reactivation in infected neurons are still unknown. Several studies have reported that during HSV-1 epithelial infection, the virus could modulate diverse cell signaling pathways remodeling the Golgi apparatus (GA) membranes, but the molecular mechanisms implicated, and the functional consequences to neurons is currently unknown. Here we report that infection of primary neuronal cultures with HSV-1 triggers Src tyrosine kinase activation and subsequent phosphorylation of Dynamin 2 GTPase, two players with a role in GA integrity maintenance...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28877858/effects-of-surgical-treatment-of-hypertrophic-turbinates-on-the-nasal-obstruction-and-the-quality-of-life
#6
Katharina Stölzel, Marie Bandelier, Agnieszka J Szczepek, Heidi Olze, Steffen Dommerich
PURPOSE: Chronic hyperplasia of the inferior nasal concha is accompanied by a nasal obstruction; however, there is no standardised surgical treatment for this condition. Here, we compared the outcome of three surgical techniques frequently used to treat the hyperplasia of inferior turbinates: turbinectomy with lateralization, submucosal electrocautery and laser cautery additional to septoplasty. MATERIALS AND METHODS: One hundred and nine patients participated in this prospective randomized study upon signing written consent...
August 30, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28872513/reconstruction-of-orbital-floor-with-auricular-concha
#7
Ergin Seven, Ali Teoman Tellioglu, Emre Inozu, Hulda Rifat Ozakpinar, Ugur Horoz, Avni Tolga Eryilmaz, Sebat Karamursel
Orbital floor fractures of varying sizes commonly occur after orbital injuries and remain a serious challenge. Serious complications of such fractures include enopthalmos, restriction of extraocular movement, and diplopia. There is a dearth of literature that can be applied widely, easily, and successfully in all such situations, and therefore there is no consensus on the treatment protocol of this pathology yet. Autogenous grafts and alloplastic and allogenic materials with a wide variety of advantages and disadvantages have been discussed...
September 1, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28854833/nitrogen-balance-after-a-single-oral-consumption-of-sacha-inchi-plukenetia-vol%C3%A3%C2%BAbilis-l-protein-compared-to-soy-protein-a-randomized-study-in-humans
#8
Gustavo F Gonzales, Jennifer Tello, Alisson Zevallos-Concha, Luis Baquerizo, Lidia Caballero
Sacha inchi is a nut produced in the Peruvian Amazonian and its oil is recognized by the lowering lipids effect in humans. The remaining material transformed to flour has a higher amount of protein, but, the nitrogen balance once ingested orally has not been studied. The present study was designed to evaluate the nitrogen balance after single consumption of 30 g of sacha inchi flour and compared with that obtained after consumption of 30 g soybean flour in adult men and women. This was a double-blind cohort study in 15 men and 15 women between 18-55 years old...
August 30, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28845968/high-rate-partial-nitritation-of-municipal-wastewater-after-psychrophilic-anaerobic-pre-treatment
#9
Vojtech Kouba, Dana Vejmelková, Eva Proksova, Helene Wiesinger, Martin Concha, Petr Dolejs, Jakub Hejnic, Pavel Jenicek, Jan Bartacek
Partial nitritation/anammox can provide energy-efficient nitrogen removal from the main stream of municipal wastewater. The main bottleneck is the growth of nitrite oxidizing bacteria (NOB) at low temperatures (<15 °C). To produce effluent suitable for anammox, real municipal wastewater after anaerobic pre-treatment was treated by enriched ammonium oxidizing bacteria (AOB) in suspended sludge SBR at 12 °C. NOB were continually washed out using Aerobic Duration Control Strategy (ADCS). Solids retention time was set to 9-16 days...
August 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28843029/a-retrospective-analysis-of-538-sinonasal-fungus-ball-cases-treated-at-a-single-tertiary-medical-center-in-korea-1996-2015
#10
Young Hoon Yoon, Jun Xu, Soo Kyoung Park, Jae Hyung Heo, Yong Min Kim, Ki-Sang Rha
BACKGROUND: Sinonasal fungus ball (FB) is a type of noninvasive fungal rhinosinusitis affecting immunocompetent hosts. FB, previously considered rare, has been reported with increasing frequency. We reviewed our experience of 538 cases over the past 20 years. METHODS: We retrospectively examined clinical records including clinical presentations, radiological findings, management, and outcomes of FB patients who have undergone surgery for treatment. The number of FB patients who underwent endoscopic sinus surgery (ESS) was calculated annually...
August 26, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28831366/preschool-children-s-physical-activity-intensity-during-school-time-influence-of-school-schedule
#11
Juliana Kain, Bárbara Leyton, Fernando Concha, Michael Close, Johana Soto-Sánchez, Gabriela Salazar
Chile's Physical Activity Report Card graded the overall index on PA behavior with an F The Ministry of Sports is implementing since 2014 "Jardín Activo" (JA program) which recommends 3 weekly teacher-led PE lessons for preschool children, on half or full day attendance. We determined the effectiveness of the JA program (contribution to MVPA during school time) and assessed if effectiveness varied according to schedule. 596 five y olds, (50% boys) were selected from 66 schools; 52.9% attended half day and 47...
December 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28827237/accuracy-and-reliability-of-the-sensory-test-performed-using-the-laryngopharyngeal-endoscopic-esthesiometer-and-rangefinder-in-patients-with-suspected-obstructive-sleep-apnoea-hypopnoea-protocol-for-a-prospective-double-blinded-randomised-exploratory-study
#12
Luis Fernando Giraldo-Cadavid, Alirio Rodrigo Bastidas, Diana Marcela Padilla-Ortiz, Diana Carolina Concha-Galan, María Angelica Bazurto, Leslie Vargas
INTRODUCTION: Patients with obstructive sleep apnoea hypopnoea syndrome (OSA) might have varying degrees of laryngopharyngeal mechanical hyposensitivity that might impair the brain's capacity to prevent airway collapse during sleep. However, this knowledge about sensory compromises in OSA comes from studies performed using methods with little evidence of their validity. Hence, the purpose of this study is to assess the reliability and accuracy of the measurement of laryngopharyngeal mechanosensitivity in patients with OSA using a recently developed laryngopharyngeal endoscopic esthesiometer and rangefinder (LPEER)...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28817683/genome-wide-association-analysis-of-cold-tolerance-at-germination-in-temperate-japonica-rice-oryza-sativa-l-varieties
#13
Ester Sales, Juan Viruel, Concha Domingo, Luis Marqués
A pool of 200 traditional, landraces and modern elite and old cultivars of rice, mainly japonica varieties adapted to temperate regions, have been used to perform a genome wide association study to detect chromosome regions associated to low temperature germination (LTG) regulation using a panel of 1672 SNP markers. Phenotyping was performed by determining growth rates when seeds were germinated at 25° and 15°C in order to separate the germination vigorousness from cold tolerance effects. As expected, the ability to produce viable seedlings varied widely among rice cultivars and also depended greatly on temperature...
2017: PloS One
https://www.readbyqxmd.com/read/28806310/the-prevention-of-recurrent-cholesteatoma-in-cwu-surgery-the-use-of-titanium-sheeting
#14
Bruce Black, Ian Gutteridge
OBJECTIVE: Assessment of the outcomes of a technique of prevention of recurrent cholesteatoma in canal wall up (CWU) mastoidectomy, using titanium sheeting to repair the external auditory canal wall. PATIENTS: Sixty four cholesteatoma cases were managed during a period from 2007 to 2015. The cases were unselected; the surgery was performed by the senior author. Cholesteatoma Patterns Were: Forty two attic, nine pars tensa, seven combined attic-pars tensa, three congenital, and three other...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28801921/autophagy-impairment-by-caspase-1-dependent-inflammation-mediates-memory-loss-in-response-to-%C3%AE-amyloid-peptide-accumulation
#15
Lourdes Álvarez-Arellano, Martha Pedraza-Escalona, Tonali Blanco-Ayala, Nohemí Camacho-Concha, Javier Cortés-Mendoza, Leonor Pérez-Martínez, Gustavo Pedraza-Alva
β-Amyloid peptide accumulation in the cortex and in the hippocampus results in neurodegeneration and memory loss. Recently, it became evident that the inflammatory response triggered by β-Amyloid peptides promotes neuronal cell death and degeneration. In addition to inflammation, β-Amyloid peptides also induce alterations in neuronal autophagy, eventually leading to neuronal cell death. Thus, here we evaluated whether the inflammatory response induced by the β-Amyloid peptides impairs memory via disrupting the autophagic flux...
August 12, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28751893/patients-lacking-a-kir-ligand-of-hla-group-c1-or-c2-have-a-better-outcome-after-umbilical-cord-blood-transplantation
#16
Carmen Martínez-Losada, Carmen Martín, Rafael Gonzalez, Bárbara Manzanares, Estefania García-Torres, Concha Herrera
Donor natural killer (NK) cells can destroy residual leukemic cells after allogeneic hematopoietic stem cell transplantation. This effect is based on the interaction of killer-cell immunoglobulin-like receptors (KIR) of donor NK cells with ligands of the major histocompatibility complex found on the surface of the target cells. HLA-C1 subtypes provide the ligand for KIR2DL2 and KIR2DL3 and the HLA-C2 subtypes for KIR2DL1. We have studied the probability of relapse (PR) after single-unit unrelated cord blood transplantation (UCBT) in relation to the potential graft-vs...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28748628/reproductive-phenology-of-creole-horses-in-ecuador-in-the-absence-of-photoperiod-variation-the-effects-of-forage-availability-and-flooding-affecting-body-condition-of-mares
#17
Juan Carranza, Washington A Yoong, Concha Mateos, Belén Caño Vergara, Chian L Gómez, Verónica Macías
Horse reproduction tends to be seasonal. The main adjusting factor in their original temperate ranges is photoperiod variation, although it is absent in equatorial areas where horses were introduced by European colonizers. Hence, dates of reproduction in these areas may be influenced by factors affecting mares' conditions and the success of foaling. Here we study reproductive timing in Creole horses in Ecuador reared in an extensive production system. We found that foaling peaked in August. Mares' conditions showed one peak in June-July, before the start of the breeding season, and another in December, and it was highly variable along the year...
July 27, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28729182/correlation-of-quantitative-mr-imaging-findings-with-symptoms-in-patients-with-incidentally-detected-inflammatory-sinonasal-disease
#18
O Kilickesmez, O Onerci Celebi, M Yalcinkaya, A R Gokduman, Y Karagoz, O Yigit
PURPOSE: To assess the relationships between mucosal thickness, T1-weighted, T2-weighted signals and restricted diffusion on magnetic resonance imaging (MRI) with the degree of symptoms in patients with incidentally detected inflammatory sinonasal disease. MATERIALS AND METHODS: Conventional and diffusion-weighted MRI of 100 patients with incidental sinonasal mucosal thickening were prospectively evaluated. There were 53 men and 47 women, with a mean age of 44.6 years±15...
July 17, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28708642/a-novel-rhinoplasty-sculpture-technique-using-ancient-chinese-architectural-technology
#19
Melia Bogari, Andy Tan, Li Lin, Zin Mar Aung, Yu Xin, Haisong Xu, Gang Chai, Yan Zhang
Rhinoplasty is one of the most delicate procedures in plastic and reconstructive surgery. Precision in every millimeter is vital in ensuring a better quality of surgical outcome. Many methods have been developed to fulfill this requirement. One such method is an implant, whether autogenous or artificial. Artificial implants involve several surgical complications, such as recipient rejection of implant material, infections, and rigid feel of the nasal tip. Hence, autogenous implants were eventually more widely applied, with material being obtained from the septum, concha, or rib cartilages...
September 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28683847/paediatric-orbital-cellulitis-and-the-relationship-to-underlying-sinonasal-anatomy-on-computed-tomography
#20
R A Crosbie, W A Clement, H Kubba
OBJECTIVE: To assess if there is an association between sinonasal anatomical variants and the risk of developing orbital cellulitis and associated complications, in children. METHODS: A retrospective case-control series was conducted, examining computed tomography confirmed sinonasal anatomical variants of septal deviation and concha bullosa in children who presented with periorbital cellulitis who went on to develop orbital cellulitis and abscesses. RESULTS: Thirty children had a Chandler score of 2 or greater on computed tomography...
August 2017: Journal of Laryngology and Otology
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