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https://www.readbyqxmd.com/read/29330304/efficient-prion-disease-transmission-through-common-environmental-materials
#1
Sandra Pritzkow, Rodrigo Morales, Adam Lyon, Luis Concha-Marambio, Akihiko Urayama, Claudio Soto
Prion diseases are a group of fatal neurodegenerative diseases associated with a protein-based infectious agent, termed prion. Compelling evidence suggests that natural transmission of prion diseases is mediated by environmental contamination with infectious prions. We hypothesized that several natural and man-made materials, commonly found in the environments of wild and captive animals, can bind prions and may act as vectors for disease transmission. To test our hypothesis, we exposed surfaces composed of various common environmental materials (i...
January 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29318861/-clinical-trials-for-treatment-of-allergic-rhinitis-with-heat-sensitive-moxibustion-and-its-regularity-of-heat-sensitization-acupoint-distribution
#2
Yu-Fen Lin, Jian-Min Lu, Yan-Na Su, Ze-Bin Zhong, Zuo-Dan Zhang
OBJECTIVE: To observe the clinical effect of heat sensitive moxibustion (HSM) and its regularity of acupoint heat-sensitization in the treatment of allergic rhinitis (AR) patients. METHODS: Seventy patients with AR were randomly divided into HSM and manual acupuncture groups (n=35/group). For patients of the HSM group, acupoints Yintang (EX-HN 3), bilateral Yingxiang (LI 20), Shangxing (GV 23), Tongtian (BL 7), Feishu (BL 13), Hegu (LI 4), etc. were used, and for patients of the manual acupuncture group, bilateral LI 20 and LI 4, Bitong (EX-HN 8) and EX-HN 3 were needled and stimulated with uniform reinforcing-reducing needling method...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29303136/role-of-anatomic-variations-of-paranasal-sinuses-on-the-prevalence-of-sinusitis-computed-tomography-findings-of-350-patients
#3
M Kaya, F Çankal, M Gumusok, N Apaydin, I Tekdemir
OBJECTIVE: The aim of this study was to determine the frequency of anatomic variations of the paranasal sinuses and their roles in the development of sinusitis. MATERIALS AND METHODS: Computed tomography of paranasal sinuses of 350 patients was assessed in terms of anatomic variations and inflammatory sinus pathology. The coexistence of anatomic variations with sinusitis was statistically investigated. RESULTS: At least one anatomical variation of paranasal sinuses was detected in 325 patients (92...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29301576/predicting-7-day-30-day-and-60-day-all-cause-unplanned-readmission-a-case-study-of-a-sydney-hospital
#4
Yashar Maali, Oscar Perez-Concha, Enrico Coiera, David Roffe, Richard O Day, Blanca Gallego
BACKGROUND: The identification of patients at high risk of unplanned readmission is an important component of discharge planning strategies aimed at preventing unwanted returns to hospital. The aim of this study was to investigate the factors associated with unplanned readmission in a Sydney hospital. We developed and compared validated readmission risk scores using routinely collected hospital data to predict 7-day, 30-day and 60-day all-cause unplanned readmission. METHODS: A combination of gradient boosted tree algorithms for variable selection and logistic regression models was used to build and validate readmission risk scores using medical records from 62,235 live discharges from a metropolitan hospital in Sydney, Australia...
January 4, 2018: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29287217/association-of-white-matter-diffusion-characteristics-and-cognitive-deficits-in-temporal-lobe-epilepsy
#5
Raúl Rodríguez-Cruces, Leticia Velázquez-Pérez, Ildefonso Rodríguez-Leyva, Ana Luisa Velasco, David Trejo-Martínez, Héctor Manuel Barragán-Campos, Vicente Camacho-Téllez, Luis Concha
OBJECTIVE: The purpose of this study was to evaluate the relation between cognitive performance and white matter (WM) integrity in patients with temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS). METHODS: We included 26 patients with TLE (10 right, 16 left onset) as well as 24 healthy controls matched for age, gender, and years of education. In addition to quantitative hippocampal volume and transverse relaxation (T2) evaluation, whole-brain WM was analyzed using fractional anisotropy (FA) maps, derived from the diffusion tensor model...
December 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29283946/rhinogenic-contact-point-headache-surgical-treatment-versus-medical-treatment
#6
Ignazio La Mantia, Calogero Grillo, Claudio Andaloro
Rhinogenic contact point headache (RCPH) is a headache syndrome secondary to mucosal contact points in the sinonasal cavities, in the absence of inflammatory signs, hyperplastic mucosa, purulent discharge, sinonasal polyps, or masses. It may result from pressure on the nasal mucosa due to anatomic variations among which the septal deviation, septal spur, and concha bullosa, are the most commonly observed. In recent years, RCPH has remained a subject of controversy regarding both its pathogenesis and treatment...
December 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29282898/a-perspective-on-proteomics-of-infectious-diseases
#7
Apoorva Venkatesh, Concha Gil, Manuel Fuentes, Joshua LaBaer, Sanjeeva Srivastava
Pneumonia, HIV/AIDS, tuberculosis, malaria and several other diseases caused by pathogens largely contribute to the enormous burden of infectious diseases. Over the last few decades, the impact of infectious diseases on a population has been drastic and remains a major health concern even today. Despite advances in science and technology in this era of health and development, there is a substantial knowledge gap in our understanding of the molecular basis of these infectious diseases. The availability of valuable genomic information for a number of pathogens and their hosts has improved our understanding of disease pathogenesis but has not always been useful in addressing important biological questions...
December 28, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29280563/characterization-of-the-proteome-of-theobroma-cacao-beans-by-nanouhplc-esi-ms-ms
#8
Emanuele Scollo, David Neville, M Jose Oruna-Concha, Martine Trotin, Rainer Cramer
Cocoa seed storage proteins play an important role in flavour development as aroma precursors are formed from their degradation during fermentation. Major proteins in the beans of Theobroma cacao are the storage proteins belonging to the vicilin and albumin classes. Although both these classes of proteins have been extensively characterized, there is still limited information on the expression and abundance of other proteins present in cocoa beans. This work is the first attempt to characterize the whole cocoa bean proteome by nanoUHPLC-ESI MS/MS analysis using tryptic digests of cocoa bean protein extracts...
December 27, 2017: Proteomics
https://www.readbyqxmd.com/read/29258782/corticotherapy-vs-corticotherapy-plus-immunosuppressive-therapy-in-acute-vogt-koyanagi-harada-disease
#9
L E Concha-Del Río, L Gómez, L Arellanes-García
INTRODUCTION: Vogt-Koyanagi-Harada disease is a multisystem disorder characterized by a bilateral granulomatous panuveitis. Multiple therapeutic regimens have been used to control inflammation in acute uveitic stage to prevent irreversible visual loss. The purpose of this paper is to compare the effect, on functional and anatomic outcomes, of early treatment with standard corticotherapy vs. corticotherapy plus immunosuppressive (IMT) therapy in acute Vogt-Koyanagi-Harada disease (Group A vs Group B)...
December 16, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29244784/factors-associated-to-inpatient-mortality-rates-in-type-2-diabetic-patients-a-cross-sectional-analytical-study-in-three-peruvian-hospitals
#10
Noé Atamari-Anahui, Franklin W Martinez-Ninanqui, Liz Paucar-Tito, Luz Morales-Concha, Alejandra Miranda-Chirau, Marco Antonio Gamarra-Contreras, Carlos Antonio Zea-Nuñez, Christian R Mejia
INTRODUCTION: Diabetes mortality has increased in recent years. In Peru, there are few studies on in-hospital mortality due to type 2 diabetes in the provinces. OBJECTIVE: To determine factors associated to hospital mortality in patients with diabetes mellitus type 2 in three hospitals from Cusco-Peru. METHODS: An analytical cross-sectional study was performed. All patients with diabetes mellitus type 2 hospitalized in the city of Cusco during the 2016 were included...
December 5, 2017: Medwave
https://www.readbyqxmd.com/read/29239475/the-production-of-hydrolysates-from-industrially-defatted-rice-bran-and-its-surface-image-changes-during-extraction
#11
Geerada Kaewjumpol, Maria J Oruna-Concha, Keshavan Niranjan, Supawan Thawornchinsombut
BACKGROUND: This research employed mild-subcritical alkaline water extraction (SAW) technique to overcome the difficulty of active compounds extractability from an industrially defatted rice bran (IDRB). Mild-SAW (pH 9.5, 130 °C, 120 min) treatment, followed by enzymatic hydrolysis (Protease G6) were applied to produce rice bran hydrolysate (RBH). Response surface methodology was used to identify proteolysis conditions for maximizing protein content and ABTS radical scavenging activity (ABTS-RSA)...
December 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29231433/-transcutaneous-vagus-nerve-stimulation-for-primary-insomnia-and-affective-disorder-a-report-of-35-cases
#12
Man Luo, Xiaoxiao Qu, Shaoyuan Li, Jingjun Zhao, Yufeng Zhao, Yue Jiao, Peijing Rong
OBJECTIVE: To observe and evaluate the clinical efficacy of transcutaneous vagus nerve stimulation (taVNS) at auricular concha for primary insomnia (PI) and affective disorder. METHODS: A total of 35 patients who met the diagnosis standard of PI in Diagnostic and statistical manual of mental disorders (5th edition) were included. The self-developed auricular vagus nerve stimulator (TENS-200A) was applied at auricular concha, 30 min per treatment, twice a day, 5 days a week for consecutive 4 weeks...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29227798/histological-and-mri-markers-of-white-matter-damage-in-focal-epilepsy
#13
REVIEW
Francesco Deleo, Maria Thom, Luis Concha, Andrea Bernasconi, Boris C Bernhardt, Neda Bernasconi
Growing evidence highlights the importance of white matter in the pathogenesis of focal epilepsy. Ex vivo and post-mortem studies show pathological changes in epileptic patients in white matter myelination, axonal integrity, and cellular composition. Diffusion-weighted MRI and its analytical extensions, particularly diffusion tensor imaging (DTI), have been the most widely used technique to image the white matter in vivo for the last two decades, and have shown microstructural alterations in multiple tracts both in the vicinity and at distance from the epileptogenic focus...
November 23, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29223801/the-external-face-of-candida-albicans-a-proteomic-view-of-the-cell-surface-and-the-extracellular-environment
#14
Ana Gil-Bona, Ahinara Amador-García, Concha Gil, Lucia Monteoliva
The cell surface and secreted proteins are the initial points of contact between Candida albicans and the host. Improvements in protein extraction approaches and mass spectrometers have allowed researchers to obtain a comprehensive knowledge of these external subproteomes. In this paper, we review the published proteomic studies that have examined C. albicans extracellular proteins, including the cell surface proteins or surfome and the secreted proteins or secretome. The use of different approaches to isolate cell wall and cell surface proteins, such as fractionation approaches or cell shaving, have resulted in different outcomes...
December 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29182200/-epigenetics-of-polycystic-ovary-syndrome
#15
REVIEW
Francisca Concha C, Teresa Sir P, Sergio E Recabarren, Francisco Pérez B
Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance. Recently, epigenetic mechanisms have been involved in the pathogenesis of PCOS. Several studies showed that methylation in DNA and miRNAs is altered in women with PCOS in blood, serum, adipose tissue, granulose cells and theca...
July 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29179964/a-case-of-multifocal-medulloblastoma-in-an-adult-patient
#16
Rose Marie Hernández Cancela, Jorge Pombo Otero, Angel Concha-Lopez
Only five cases of multifocal medulloblastoma in the adult have been reported to date. We present a case in a male patient in his 50th decade of life who presented with three extra-axial lesions associated with a parenchymatous lesion of the right middle cerebellar peduncle. Sputum sample examination revealed larvae compatible with strongyloides stercoralis, which was our main differential diagnosis. Histological and immunohistochemical studies revealed the existence of a desmoplastic medulloblastoma.
January 2017: Revista Española de Patología
https://www.readbyqxmd.com/read/29140904/reconstruction-of-microtias-with-constricted-ear-features-a-22-year-experience
#17
Chul Park, Jung Youl Park
BACKGROUND: The surgical correction of 'microtias with constricted ear features' has remained a challenge due to the variable shape and large volume of the remnant cartilage and skin involved. In order to clarify how this remnant cartilage and skin should be treated, we have reviewed and analyzed cases operated at our Center. METHODS: A total of 167 cases of Microtia with Constricted Ear Features, operated from 1992 to 2014, were included in the study. They were reviewed through medical records and photographs, analysis of surgical methods, and postoperative outcomes...
November 11, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29130063/stress-self-regulation-and-context-evidence-from-the-health-and-retirement-survey
#18
Briana Mezuk, Scott Ratliff, Jeannie B Concha, Cleopatra M Abdou, Jane Rafferty, Hedwig Lee, James S Jackson
Health-related behaviors, such as smoking, alcohol use, exercise, and diet, are major determinants of physical health and health disparities. However, a growing body of experimental research in humans and animals also suggests these behaviors can impact the ways our bodies respond to stress, such that they modulate (that is, serve as a means to self-regulate or cope with) the deleterious impact of stressful experiences on mental health. A handful of epidemiologic studies have investigated the intersection between stress and health behaviors on health disparities (both mental and physical), with mixed results...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29126017/epidermal-growth-factor-receptor-overexpression-and-outcomes-in-early-breast-cancer-a-systematic-review-and-a-meta-analysis
#19
REVIEW
Galileo A Gonzalez-Conchas, Laura Rodriguez-Romo, David Hernandez-Barajas, Juan F Gonzalez-Guerrero, Ivan A Rodriguez-Fernandez, Adrian Verdines-Perez, Arnoud J Templeton, Alberto Ocana, Bostjan Seruga, Ian F Tannock, Eitan Amir, Francisco E Vera-Badillo
BACKGROUND: The epidermal growth factor receptor (EGFR) is a member of the ErbB family of membrane tyrosine-kinase receptors. Studies exploring the prognostic role of EGFR-overexpression in early breast cancer have shown variable results, and the true prognostic value of EGFR is unknown. METHODS: A systematic review of identified publications exploring the association between EGFR-overexpression (as defined from different techniques and cut-offs) and outcomes [disease-free (DFS) and, overall survival (OS)] in women with early breast cancer...
January 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29121369/endoscopic-view-of-a-drainage-pathway-of-a-concha-bullosa
#20
Eiji Yanagisawa, Dewey A Christmas, Joseph P Mirante
No abstract text is available yet for this article.
October 2017: Ear, Nose, & Throat Journal
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