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https://www.readbyqxmd.com/read/29688804/are-patients-with-spontaneous-csf-otorrhea-and-superior-canal-dehiscence-congenitally-predisposed-to-their-disorders
#1
Shawn M Stevens, Kiefer Hock, Ravi N Samy, Myles L Pensak
Objectives (1) Compare lateral skull base (LSB) height/thickness in patients with spontaneous cerebrospinal fluid otorrhea (CSF), superior canal dehiscence (SCD), acoustic neuromas (AN), and otosclerosis (OTO). (2) Perform correlations between age, body mass index (BMI), sex, and LSB height/thickness. Study Design Case series with chart review. Setting Tertiary referral center. Subjects and Methods Patients with CSF, SCD, AN, and OTO diagnosed from 2006 to 2016 were included if they had high-definition temporal bone computed tomography (CT) and absence of trauma, radiation, chronic ear disease, and/or congenital anomaly...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29685616/supra-threshold-auditory-brainstem-response-amplitudes-in-humans-test-retest-reliability-electrode-montage-and-noise-exposure
#2
Garreth Prendergast, Wenhe Tu, Hannah Guest, Rebecca E Millman, Karolina Kluk, Samuel Couth, Kevin J Munro, Christopher J Plack
The auditory brainstem response (ABR) is a sub-cortical evoked potential in which a series of well-defined waves occur in the first 10 ms after the onset of an auditory stimulus. Wave V of the ABR, particularly wave V latency, has been shown to be remarkably stable over time in individual listeners. However, little attention has been paid to the reliability of wave I, which reflects auditory nerve activity. This ABR component has attracted interest recently, as wave I amplitude has been identified as a possible non-invasive measure of noise-induced cochlear synaptopathy...
April 6, 2018: Hearing Research
https://www.readbyqxmd.com/read/29678818/angiolymphoid-hyperplasia-of-external-ear-treated-with-intralesional-radiofrequency-ablation
#3
Deepika Yadav, Sanjay Singh, Neetu Bhari, Somesh Gupta
A 21-year-old woman presented with multiple erythematous to skin-coloured dome-shaped firm papules and plaques over the right ear concha and external auditory canal for 1 year. It was associated with occasional itching and bleeding. Her main concern was cosmetic disfigurement. Biopsy showed presence of multiple proliferating blood vessels lined by plump epithelioid endothelial cells surrounded by dense infiltrate of lymphocytes, histiocytes and eosinophils. Other routine investigations were within normal limits...
April 20, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29670222/stem-cells-in-middle-ear-cholesteatoma-contribute-to-its-pathogenesis
#4
Julia Nagel, Saskia Wöllner, Matthias Schürmann, Viktoria Brotzmann, Janine Müller, Johannes Fw Greiner, Peter Goon, Barbara Kaltschmidt, Christian Kaltschmidt, Holger Sudhoff
Cholesteatoma is a potentially life-threatening middle ear lesion due to the formation of an inflamed ectopic mass of keratinizing squamous epithelium. Surgical removal remains the only treatment option, emphasizing the need to gain a better understanding of this severe disease. We show for the first time that stem cells residing in cholesteatoma tissue contribute to disease progression. Cells expressing the "stemness" markers Nestin and S100B were detected in middle ear cholesteatoma and auditory canal skin...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667447/exposure-to-non-ionizing-electromagnetic-fields-emitted-from-mobile-phones-induced-dna-damage-in-human-ear-canal-hair-follicle-cells
#5
Mehmet Akdag, Suleyman Dasdag, Fazile Canturk, Mehmet Zulkuf Akdag
The aim of this study was to investigate effect of radiofrequency radiation (RFR) emitted from mobile phones on DNA damage in follicle cells of hair in the ear canal. The study was carried out on 56 men (age range: 30-60 years old)in four treatment groups with n = 14 in each group. The groups were defined as follows: people who did not use a mobile phone (Control), people use mobile phones for 0-30 min/day (second group), people use mobile phones for 30-60 min/day (third group) and people use mobile phones for more than 60 min/day (fourth group)...
April 18, 2018: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/29664150/conductive-hearing-loss-in-four-dogs-associated-with-the-use-of-ointment-based-otic-medications
#6
Lynette K Cole, Päivi J Rajala-Schultz, Gwendolen Lorch
BACKGROUND: Hearing loss (HL) is classified as conductive when sound transmission is compromised in the ear canal or middle ear, or sensorineural when there is an abnormality of the receptor cells of the cochlea or auditory pathway. Hearing in dogs is evaluated using the brainstem auditory evoked response (BAER) test. HYPOTHESIS/OBJECTIVES: Our objective was to characterize BAER findings pre- and post-ear flushing in four dogs with acute HL following application of an ointment-based otic medication containing betamethasone, clotrimazole and gentamicin in a mineral oil-based system containing a plasticized hydrocarbon gel...
April 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29659020/surgical-management-of-chronic-otitis-secondary-to-craniomandibular-osteopathy-in-three-west-highland-white-terriers
#7
L Beever, F Swinbourne, S L Priestnall, G Ter Haar, D J Brockman
Three West Highland white terriers were presented for investigation of left-sided para-aural abscessation. CT revealed chronic otitis media with extensive osseous proliferation surrounding the horizontal and vertical ear canals contiguous with the expanded temporal bone, consistent with a unilateral variant of craniomandibular osteopathy. A left total ear canal ablation with lateral bulla osteotomy was performed in all dogs. An ultrasonic bone curette (Sonopet; Stryker) proved useful when removing the osseous proliferation in two dogs...
April 16, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29651401/rehabilitation-of-an-auricular-defect-using-surgical-stent
#8
Mahnaz Arshad, Gholamreza Shirani, Sina Refoua
Reconstruction of a facial defect is a complex modality either surgically or prosthetically, depending on the site, size, etiology, severity, age, and the patient's expectation. The loss of an auricle, in the presence of an auditory canal, affects hearing, because the auricle gathers sound and directs it into the canal. The auricle acts as a resonator to slightly amplify lower frequency sounds and helps to localize sounds, especially in conjunction with the other ear. Osseointegrated implants have an important role in the prosthetic reconstruction of patients with craniofacial defects...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29649043/permeation-enhancers-for-intratympanically-applied-drugs-studied-using-fluorescent-dexamethasone-as-a-marker
#9
Wei Li, Jared J Hartsock, Chunfu Dai, Alec N Salt
HYPOTHESIS: Entry of locally applied drugs into the inner ear can be enhanced by chemical manipulations. BACKGROUND: Perilymph drug concentrations achieved by intratympanic applications are well below the applied concentration due to limited entry through the round window (RW) membrane and stapes. Chemical manipulations to increase entry permeability could increase the effectiveness of drug therapy with local applications. METHODS: Dexamethasone-fluorescein (F-dex) was used as an entry marker...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29629231/internal-auditory-canal-exostosis-a-technical-case-report
#10
Lynn Mubita, Michael Seidman, Jack Rock
Background: Exostoses of the internal auditory canal is a rare finding that may present with disabling symptoms of dizziness, hearing loss, and vestibular dysfunction based on the extent of cranial nerve compression. The purpose of this case report is to discuss the presentation and outcomes in a patient who presented with this disorder. Case Description: A 19-year-old female presented to the neurotologist with left ear discomfort, pain with left lateral gaze, and dizziness...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29628872/excitation-of-the-auditory-system-as-a-result-of-non-invasive-extra-cochlear-stimulation-in-normal-subjects-and-tinnitus-patients
#11
Marzena Mielczarek, Arnaud Norena, Winfried Schlee, Jurek Olszewski
One of possible approach that may suppress tinnitus is electrical stimulation of the ear. At first invasive techniques were used (promontory or round window stimulation), nowadays a non-invasive method, namely hydrotransmissive electric stimulation (ES) through external acoustic canal, has been developed. The aim of the study is to investigate the effect of applying ES with positive and negative current polarities on the ears of healthy subjects and on the tinnitus ears of patients with tinnitus. This comparison further clarifies the mechanisms of operation of non-invasive extra-cochlear ear ES...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29616157/erosive-benign-fibro-osseous-lesion-of-the-external-auditory-canal
#12
Ganesh Vihapure, Vivek Dokania, Nimish Thakral
The term fibro-osseous lesion encompasses a spectrum of disorders ranging from inflammatory to neoplastic that microscopically exhibit a connective tissue matrix containing formless trabeculae of compact bone. Characteristically, they are located over healthy bone, from which they are abruptly differentiated. The majority of the lesions arise from the maxillofacial region; the occurrence of a lesion in the external auditory canal (EAC) being extremely rare as is in our case. The lesions present with a range of symptoms ranging from conductive hearing loss, Eustachian tube obstruction to bone erosion that develop due to the mass effect...
February 1, 2018: Curēus
https://www.readbyqxmd.com/read/29604713/effect-of-mouth-opening-levels-on-sound-field-gain-in-the-ear-canal
#13
Jen-Fang Yu, Hsiang-Chi Hsien, Kun-Che Lee, Jimg-Hong Xiao, Hsiu-Hui Chiu, Hsiang-Hsi Hong, Yu-Fu Shen, Ying-Chin Peng
The human external auditory canal can become deformed when the mandible moves, and this changes the sound field in the external auditory canal. This study measured the sound field gain in the external auditory canal while varying mouth-opening in three levels. The mandible was fixed at the 1/3, the 2/3, and the maximal mouth-opening levels. Seven 65-dB tones of 200, 500, 1000, 2000, 4000, 6000, and 8000 Hz, which are the sound pressure level and frequency range when people are talking at a normal level, were adopted as the sound stimulus to measure sound field gains at 5, 10, 15, and 20 mm to the interior of the external auditory canal...
March 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29604709/quantifying-undesired-parallel-components-in-th%C3%A3-venin-equivalent-acoustic-source-parameters
#14
Kren Rahbek Nørgaard, Stephen T Neely, Daniel M Rasetshwane
The calibration of an ear probe to determine its Thévenin-equivalent acoustic source parameters facilitates the measurement of ear-canal impedance and reflectance. Existing calibration error metrics, used to evaluate the quality of a calibration, are unable to reveal undesired parallel components in the source parameters. Such parallel components can result from, e.g., a leak in the ear tip or improperly accounting for evanescent modes, and introduce errors into subsequent measurements of impedance and reflectance...
March 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29602456/are-human-atp-binding-cassette-transporter-c11-and-earwax-associated-with-the-incidence-of-cholesteatoma
#15
Hiroshi Nakagawa, Yu Toyoda, Tobias Albrecht, Megumi Tsukamoto, Mark Praetorius, Toshihisa Ishikawa, Kazusaku Kamiya, Takeshi Kusunoki, Katsuhisa Ikeda, Serkan Sertel
Cholesteatoma is an ear disease based on a locally destructive noncancerous conglomerate of epidermis and keratin debris. Abnormal growth of stratified keratinized squamous epithelium in the temporal bone causes destruction of the outer and middle ear, potentially leading to hearing impairment, facial palsy, vertigo, lateral sinus thrombosis, and intracranial complications. Although cholesteatoma is effectively treated by surgical resection (mastoidectomy), the lack of effective and nonsurgical therapies potentially results in fatal consequences, establishing the need for a comprehensive investigation of cholesteatoma pathogenesis...
May 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29599061/cholesteatoma-labyrinthine-fistula-prevalence-and-impact
#16
Letícia P Schmidt Rosito, Inesângela Canali, Adriane Teixeira, Mauricio Noschang Silva, Fábio Selaimen, Sady Selaimen da Costa
INTRODUCTION: Labyrinthine fistula is one of the most common complications associated with cholesteatoma. It represents an erosive loss of the endochondral bone overlying the labyrinth. Reasons for cholesteatoma-induced labyrinthine fistula are still poorly understood. OBJECTIVE: Evaluate patients with cholesteatoma, in order to identify possible risk factors or clinical findings associated with labyrinthine fistula. Secondary objectives were to determine the prevalence of labyrinthine fistula in the study cohort, to analyze the role of computed tomography and to describe the hearing results after surgery...
March 9, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29574745/a-new-method-for-selecting-auricle-positions-in-skull-base-reconstruction-for-temporal-bone-cancer
#17
Kentaro Tanaka, Tomoyuki Yano, Tsutomu Homma, Atsunobu Tsunoda, Masaru Aoyagi, Seiji Kishimoto, Mutsumi Okazaki
OBJECTIVE: In advanced temporal bone carcinoma cases, we attempted to preserve as much of the auricle as possible from a cosmetic and functional perspective. Difficulties are associated with selecting an adequate position for reconstructed auricles intraoperatively. We improved the surgical procedure to achieve a good postoperative auricle position. METHODS: Nine patients were included in this study. All patients underwent subtotal removal of the temporal bone and resection of the external auditory canal while preserving most of the external ear, and lateral skull base reconstruction was performed with anterolateral thigh flaps...
March 25, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29570699/microrna-194-regulates-the-development-and-differentiation-of-sensory-patches-and-statoacoustic-ganglion-of-inner-ear-by-fgf4
#18
Hui Cao, Jianbo Shi, Jintao Du, Kaitian Chen, Chang Dong, Di Jiang, Hongyan Jiang
BACKGROUND MicroRNA 194 is involved in the differentiation of various types of cells, such as adipose derived stem cells, human embryonic stem cells, and bone marrow mesenchymal stem cells. Previously, we found that miR-194 was highly expressed in the inner ear sensory patch and neurons in mice embryos. However, the role of miR-194 in the development of the inner ear and its underlying mechanism have not been elucidated yet. MATERIAL AND METHODS The expression level of miR-194 has been altered by using antisense morpholino oligonucleotides (MO) and synthesized miRNAs in zebrafish...
March 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29567474/treacher-collins-syndrome-3-tcs3-associated-polr1c-mutants-are-localized-in-the-lysosome-and-inhibits-chondrogenic-differentiation
#19
Naoto Matsumoto, Minami Kaneko, Natsumi Watanabe, Misa Itaoka, Yoich Seki, Takako Morimoto, Tomohiro Torii, Yuki Miyamoto, Keiichi Homma, Junji Yamauchi
Treacher Collins syndrome (TCS) is a craniofacial developmental disorder whose key feature is a combination of symptoms. For example, a patient could have bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids, hypoplasia of the facial bones, cleft palate, malformation of the external ears, and atresia of the external auditory canals. TCS3 is caused by mutations of the polr1c gene, which encodes RNA polymerase I and III subunit C (POLR1C). There have been two known missense mutations (Arg279-to-Gln [R279Q] and Arg279-to-Trp [R279W]) at the Arg-279 position...
March 21, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29559801/vertical-transmission-of-group-b-streptococcus-and-associated-factors-among-pregnant-women-a-cross-sectional-study-eastern-ethiopia
#20
Tesfaye Assebe Yadeta, Alemayehu Worku, Gudina Egata, Berhanu Seyoum, Dadi Marami, Yemane Berhane
Background: Vertically transmitted group B Streptococcus (GBS) causes fetal and neonatal infections. However, there is limited information on the vertical transmission of GBS in low-income countries. This study, therefore, aimed to determine the rate of vertical transmission of GBS and associated factors among pregnant women in Eastern Ethiopia. Subjects and methods: A cross-sectional, facility-based study was conducted among pregnant women in Harar town, Eastern Ethiopia, from June to October, 2016...
2018: Infection and Drug Resistance
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