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https://www.readbyqxmd.com/read/28724974/effects-of-exogenous-thymosin-%C3%AE-4-on-carbon-tetrachloride-induced-liver-injury-and-fibrosis
#1
Xiankui Li, Lei Wang, Cai Chen
The present study investigated the effects of exogenous thymosin β4 (TB4) on carbon tetrachloride (CCl4)-induced acute liver injury and fibrosis in rodent animals. Results showed that both in mice and rats CCl4 rendered significant increases in serum alanine aminotransferase and aspartate aminotransferase, hepatic malondialdehyde formation, decreases in antioxidants including superoxide dismutase and glutathione, and up-regulated expressions of transforming growth factor-β1, α-smooth muscle actin, tumor necrosis factor-α and interleukin-1β in the liver tissues...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723980/preliminary-results-of-topical-hepatic-hypothermia-in-a-model-of-liver-ischemia-reperfusion-injury-in-rats
#2
Emilio Elias Abdo, Estela Regina Ramos Figueira, Joel Avancini Rocha-Filho, Eleazar Chaib, Luiz Augusto Carneiro D'Albuquerque, Telesforo Bacchella
BACKGROUND: Ischemia/reperfusion causes organ damage but it is mandatory in hepatic transplantation, trauma and other complex liver surgeries, when Pringle maneuver is applied to minimize bleeding during these procedures. It is well known that liver ischemia/reperfusion leads to microcirculatory disturbance and cellular injury. In this setting hypothermia is known to reduce oxygen demand, lowering intracellular metabolism. OBJECTIVE: To evaluate the effects of hypothermia in liver ischemia/reperfusion injury, using a new model of topic isolated liver hypothermia...
July 6, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28721650/prediction-of-pulmonary-metastasis-in-pulmonary-nodules-%C3%A2-10%C3%A2-mm-detected-in-patients-with-primary-extrapulmonary-malignancy-at-thin-section-staging-ct
#3
Qiuxia Yang, Yiqi Wang, Xiaohua Ban, Jing Wu, Dailin Rong, Qianqian Zhao, Chuanmiao Xie, Rong Zhang
PURPOSE: To investigate the predictive clinical and imaging factors associated with pulmonary metastasis in pulmonary nodules (PNs) ≤10 mm in patients with primary extrapulmonary malignancy (PEPM) on initial CT as well as the inter-nodular imaging features in the non-solitary PNs patients, to make a more reliable diagnosis and appropriate management of the PNs at an earlier stage after detection. MATERIALS AND METHODS: 161 patients with PNs ≤10 mm were reviewed from April 2013 to December 2013...
July 18, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28716661/the-prevalence-and-morphometry-of-an-accessory-spleen-a-meta-analysis-and-systematic-review-of-22-487-patients
#4
REVIEW
Jens Vikse, Beatrice Sanna, Brandon Michael Henry, Dominik Taterra, Silvia Sanna, Przemysław A Pękala, Jerzy A Walocha, Krzysztof A Tomaszewski
BACKGROUND: An accessory spleen (AS) is a lobule of splenic tissue found in ectopic locations. Identification of AS is particularly important in patients with immune thrombocytopenia (ITP) requiring splenectomy as unrecognized AS can later cause refractory symptoms. The AS can also be a source of significant intraabdominal hemorrhage. The aim of this meta-analysis was to systematically analyze the data on the prevalence, number, location, and morphometry of AS. MATERIALS AND METHODS: An extensive search of the major electronic databases was conducted to identify all studies that reported relevant data on the AS...
July 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28716013/long-term-renal-survival-of-%C3%AE-3-heavy-chain-deposition-disease-a-case-report
#5
Takayuki Katsuno, Shige Mizuno, Masatsuna Mabuchi, Naotake Tsuboi, Atsushi Komatsuda, Shoichi Maruyama
BACKGROUND: Monoclonal immunoglobulin deposition disease (MIDD) is characterized by the non-amyloid deposition of monoclonal immunoglobulin fragments in the basement membranes. Heavy chain deposition disease (HCDD) is a type of MIDD. HCDD is an extremely rare disease, and only three cases have been reported in Japan up to the present. The prognosis of HCDD is very poor, and optimal treatment has not been established. Only a few cases of HCDD with favorable long-term renal prognosis have been reported to date...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28714728/functional-neural-changes-following-behavioral-therapies-and-disulfiram-for-cocaine-dependence
#6
Elise E DeVito, Guangheng Dong, Hedy Kober, Jiansong Xu, Kathleen M Carroll, Marc N Potenza
A growing literature exists on neural correlates of treatment outcome. However, different types-or components of-treatment have distinct theorized mechanisms of action. And it is not yet known how changes in neural activity across treatment relate to engagement in different treatment components. Participants with cocaine use disorders in a randomized clinical trial received cognitive-behavioral therapy (CBT) plus, in a 2 × 2 design, contingency management (CM) or no CM, and disulfiram or placebo. Participants performed a functional MRI Stroop task, a measure of cognitive control, at the beginning of and after the 12-week treatment...
July 17, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28713758/two-concurrent-large-epidermoid-cysts-in-sublingual-and-submental-region-resembling-plunging-ranula-report-of-a-rare-case
#7
Ranjan Kumar Sahoo, Pradyumna Kumar Sahoo, Debahuti Mohapatra, Santosh Subudhi
An elderly female patient presented to surgical outpatient clinic with complaint of gradual onset of painless submental and sublingual midline swellings for 6 months of duration. The swellings were noncompressible, nontranslucent, nonpulsatile, and nontender on palpation. Clinical diagnosis was plunging ranula or dermoid cysts. Ultrasound examination of sublingual swelling showed cystic lesion with particulate content. Submental swelling showed cystic swelling with few echogenic floating lobules inside suggesting possibility of epidermoid/dermoid cyst...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28712861/a-novel-golgi-cox-staining-method-for-detecting-and-characterizing-roles-of-the-hepatic-stellate-cells-in-liver-injury
#8
Ma de Jesús Gómez Villalobos, Susana Vidrio, Ruth Giles López, Gabriel Flores Gómez, Victoria Chagoya de Sánchez
The aim of this study was to investigate the utility of the Golgi-Cox method to characterize the distribution and morphological changes of the hepatic stellate cells (HSCs) in CCl4 liver damaged rats. Six-week-old male Wistar rats were injected with CCl4 for ten weeks. The livers were processed with the Golgi-Cox method, reticuline, and Massońs Trichrome stains, and analyzed under light microscopy. Histological evaluation of livers was made through the METAVIR score. In normal livers, the HSCs show stellate form with abundant thin cytoplasmic processes, distributed into hepatic lobule, mainly in zone 1...
June 30, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28711741/confirmation-that-mutations-in-ddx59-cause-an-autosomal-recessive-form-of-oral-facial-digital-syndrome-further-delineation-of-the-ddx59-phenotype-in-two-new-families
#9
Sara Faily, Rahat Perveen, Jill Urquhart, Kate Chandler, Jill Clayton-Smith
We report three probands from two unrelated consanguineous families of South Asian origin who all carry the same rare novel homozygous variant within the dead box helicase gene DDX59 in association with features of oral-facial-digital syndrome (OFDS). DDX59 variants have been reported previously in an unclassified, autosomal recessive form of OFDS; clinically associated with features including tongue lobulation, cleft palate, frontal bossing, hypertelorism and postaxial polydactyly. All three probands had lobulated tongues with tongue hamartomas, abnormal tongue tip, developmental delay and microcephaly, with just one proband demonstrating polydactlyly...
July 12, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28710677/cerebellar-contributions-to-persistent-auditory-verbal-hallucinations-in-patients-with-schizophrenia
#10
Maximilian Cierpka, Nadine D Wolf, Katharina M Kubera, Mike M Schmitgen, Nenad Vasic, Karel Frasch, Robert Christian Wolf
There is growing evidence that the cerebellum plays a crucial role in the pathophysiology of schizophrenia symptoms. Despite increasing evidence for cerebellar involvement in affective, attentive, and cognitive functions including language processing and perception, investigations of cerebellar contributions to auditory verbal hallucinations (AVH) in schizophrenia are lacking. Using structural magnetic resonance imaging at 3T, we investigated the data of 20 patients with schizophrenia and 14 matched healthy controls...
July 14, 2017: Cerebellum
https://www.readbyqxmd.com/read/28709492/diagnosis-at-a-glance-of-radiological-imaging
#11
Ankush Chaudhary, Unnati Desai, Vinaya Karkhanis, Jyotsna M Joshi
A 14-year-old boy was referred to our outpatient department with complaints of dry cough, high-grade fever for 20 days and chest X-ray (CXR) opacity. The clinical examination was normal. His CXR showed a right mid-zone lobulated, homogenous opacity. Computed tomography (CT) of thorax showed a well-defined cystic lesion in right upper lobe with 5-10HU (Hounsfield unit) suggesting a fluid filled cyst. CT guided aspiration of cyst was undertaken and revealed clear fluid with no cells. Post-aspiration high-resolution CT images demonstrated classical signs of hydatid cyst...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28707166/altered-dynamic-functional-connectivity-in-the-default-mode-network-in-patients-with-cirrhosis-and-minimal-hepatic-encephalopathy
#12
Hua-Jun Chen, Hai-Long Lin, Qiu-Feng Chen, Peng-Fei Liu
PURPOSE: Abnormal brain intrinsic functional connectivity (FC) has been documented in minimal hepatic encephalopathy (MHE) by static connectivity analysis. However, changes in dynamic FC (dFC) remain unknown. We aimed to identify altered dFC within the default mode network (DMN) associated with MHE. METHODS: Resting-state functional MRI data were acquired from 20 cirrhotic patients with MHE and 24 healthy controls. DMN seed regions were defined using seed-based FC analysis (centered on the posterior cingulate cortex (PCC))...
July 13, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28707157/parcellation-of-macaque-cortex-with-anatomical-connectivity-profiles
#13
Jiaojian Wang, Zhentao Zuo, Sangma Xie, Yifan Miao, Yuanye Ma, Xudong Zhao, Tianzi Jiang
The macaque model has been widely used to investigate the brain mechanisms of specific cognitive functions and psychiatric disorders. However, a detailed functional architecture map of the macaque cortex in vivo is still lacking. Here, we aimed to construct a new macaque cortex atlas based on its anatomical connectivity profiles using in vivo diffusion MRI. First, we defined the macaque cortical seed areas using the NeuroMaps atlas. Then, we applied the anatomical connectivity patterns-based parcellation approach to parcellate the macaque cortex into 80 subareas in each hemisphere, which were approximately symmetric between the two hemispheres...
July 13, 2017: Brain Topography
https://www.readbyqxmd.com/read/28704893/clinical-characteristics-of-idiopathic-epidermoid-and-dermoid-cysts-of-the-ear
#14
Yesun Cho, Dong-Hee Lee
BACKGROUND AND OBJECTIVES: Epidermoid and dermoid cysts are benign cystic lesions, lined by ectodermal squamous epithelium. They are not common in the head and neck areas, which constitute ~7% of all cases of epidermoid and dermoid cysts. The aim of this study was to investigate the clinical characteristics of epidermoid and dermoid cysts that developed around the ear. SUBJECTS AND METHODS: The clinical records were retrospectively reviewed for patients confirmed histologically as idiopathic epidermoid and dermoid cysts of the ear from January 2011 to December 2015...
July 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28702351/activation-of-dominant-hemisphere-association-cortex-during-naming-as-a-function-of-cognitive-performance-in-mild-traumatic-brain-injury-insights-into-mechanisms-of-lexical-access
#15
Mihai Popescu, John D Hughes, Elena-Anda Popescu, Judy Mikola, Warren Merrifield, Maria DeGraba, Gerard Riedy, Thomas J DeGraba
Patients with a history of mild traumatic brain injury (mTBI) and objective cognitive deficits frequently experience word finding difficulties in normal conversation. We sought to improve our understanding of this phenomenon by determining if the scores on standardized cognitive testing are correlated with measures of brain activity evoked in a word retrieval task (confrontational picture naming). The study participants (n = 57) were military service members with a history of mTBI. The General Memory Index (GMI) determined after administration of the Rivermead Behavioral Memory Test, Third Edition, was used to assign subjects to three groups: low cognitive performance (Group 1: GMI ≤ 87, n = 18), intermediate cognitive performance (Group 2: 88 ≤ GMI ≤ 99, n = 18), and high cognitive performance (Group 3: GMI ≥ 100, n = 21)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28699075/differential-brain-activations-in-adult-attention-deficit-hyperactivity-disorder-subtypes-a-counting-stroop-functional-mri-study
#16
Chi-Yung Shang, Chia Sheng, Li-Kuang Yang, Tai-Li Chou, Susan Shur-Fen Gau
Although previous functional neuroimaging studies have found abnormal brain activations in individuals with attention deficit hyperactivity disorder (ADHD), little was known about distinct brain dysfunctions across different ADHD subtypes. The objective of the present study was to investigate the abnormal brain activations associated with two ADHD subtypes, predominantly inattentive (ADHD-PI) and combined (ADHD-C) subtypes. Twenty-five adults with ADHD-PI, 25 with ADHD-C, and 30 healthy controls (HC) participated in this study...
July 11, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28693687/abnormal-alterations-of-cortical-thickness-in-16-patients-with-type-2-diabetes-mellitus-a-pilot-mri-study-%C3%A2
#17
Chen Zhiye, Zang Xiujuan, Liu Mengqi, Liu Mengyu, Li Jinfeng, Gu Zhaoyan, Ma Lin
Objective The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus (T2DM) using a whole brain cortical thickness mapping system based on brain magnetic resonance imaging (MRI).Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 16 patients with T2DM, as well as from 16 normal controls. The whole brain cortical thickness maps were generated, and the cortical thickness of each brain region was calculated according to gyral based regions of interest (ROI) using an automated labeling system by the Freesurfer software...
June 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28690992/diabetes-mellitus-due-to-agenesis-of-the-dorsal-pancreas-in-a-patient-with-heterotaxy-syndrome
#18
Jo Eun Jung, Jin Ho Hur, Mo Kyung Jung, Ahreum Kwon, Hyun Wook Chae, Duk Hee Kim, Ho-Seong Kim
Heterotaxy syndrome (HS) is a congenital disorder resulting from an abnormal arrangement of visceral organs across the normal left-right axis in the embryonic period. HS is usually associated with multiple anomalies, including defects of the major cardiovascular system and the extracardiovascular system such as intestinal malrotation, abnormal lung lobulation, bronchus anomalies, and pancreatic dysplasia. Although pancreatic dysplasia is occasionally accompanied with HS, the occurrence of diabetes mellitus (DM) due to pancreatic dysplasia in HS is rarely reported...
June 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28688854/the-time-course-of-activation-in-the-dorsal-and-ventral-visual-streams-during-landmark-cueing-and-perceptual-discrimination-tasks
#19
Anthony J Lambert, Adrienne Wootton
Different patterns of high density EEG activity were elicited by the same peripheral stimuli, in the context of Landmark Cueing and Perceptual Discrimination tasks. The C1 component of the visual event-related potential (ERP) at parietal - occipital electrode sites was larger in the Landmark Cueing task, and source localisation suggested greater activation in the superior parietal lobule (SPL) in this task, compared to the Perceptual Discrimination task, indicating stronger early recruitment of the dorsal visual stream...
July 5, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28683830/primary-hepatic-neuroendocrine-tumors-multi-modal-imaging-features-with-pathological-correlations
#20
Kai Yang, Ying-Sheng Cheng, Ji-Jin Yang, Xu Jiang, Ji-Xiang Guo
BACKGROUND: Primary hepatic neuroendocrine carcinomas (PHNECs) are rare and asymptomatic, and are therefore difficult to distinguish radiologically from other liver carcinomas. In this study, we aimed to determine the computed tomography (CT), magnetic resonance imaging (MRI), and digital subtraction angiography (DSA) features of PHNECs. METHODS: A retrospective analysis of 11 patients with pathologically proven PHNECs was performed from January 2009 to September 2014...
July 6, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
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