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https://www.readbyqxmd.com/read/29226863/associations-between-use-of-specific-analgesics-and-concentrations-of-amyloid-%C3%AE-42-or-phospho-tau-in-regions-of-human-cerebral-cortex
#1
Margaret E Flanagan, Eric B Larson, Rod L Walker, C Dirk Keene, Nadia Postupna, Brenna Cholerton, Joshua A Sonnen, Sascha Dublin, Paul K Crane, Thomas J Montine
Analgesics are commonly used by older adults, raising the question of whether their use might contribute to dementia risk and neuropathologic changes of Alzheimer's disease (AD). The Adult Changes in Thought (ACT) study is a population-based study of brain aging and incident dementia among people 65 years or older who are community dwelling and not demented at entry. Amyloid-β (Aβ)42 and phospho-tau were quantified using Histelide in regions of cerebral cortex from 420 brain autopsies. Total standard daily doses of prescription opioid and non-aspirin nonsteroidal anti-inflammatory drug (NSAID) exposure during a defined 10-year exposure window were identified using automated pharmacy dispensing data and used to classify people as having no/low, intermediate, or high exposure...
December 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29224580/the-neural-correlates-of-childhood-trauma-questionnaire-scores-in-adults-a-meta-analysis-and-review-of-functional-magnetic-resonance-imaging-studies
#2
Sarah J Heany, Nynke A Groenewold, Anne Uhlmann, Shareefa Dalvie, Dan J Stein, Samantha J Brooks
Childhood maltreatment, including abuse and neglect, may have sustained effects on the integrity and functioning of the brain, alter neurophysiological responsivity later in life, and predispose individuals toward psychiatric conditions involving socioaffective disturbances. This meta-analysis aims to quantify associations between self-reported childhood maltreatment and brain function in response to socioaffective cues in adults. Seventeen functional magnetic resonance imaging studies reporting on data from 848 individuals examined with the Childhood Trauma Questionnaire were included in a meta-analysis of whole-brain findings, or a review of region of interest findings...
December 11, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29224275/-clinicopathologic-study-of-infiltrating-epitheliosis-of-the-breast
#3
X L Xu, X Y Tu, R H Shui, Y F Cheng, B H Yu, W T Yang
Objective: To evaluate the morphological and immunohistochemical features of infiltrating epitheliosis and its differential diagnosis. Methods: Nine consultation and routine cases of infiltrating epitheliosis diagnosed from January 2015 to December 2016 in Fudan University Shanghai Cancer Center were collected. All tissues were formalin-fixed paraffin-embedded and routinely HE stained. The HE slides were reviewed. Immunohistochemical staining of CKpan, CK7, CK19, CK5/6, CK14, p63, SMMHC, Calponin, ER, PR, HER2, Ki-67 and S-100 protein was performed using Ventana BenchMark automated immunostainer...
December 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29222961/liver-zonation-in-children-with-nafld-associations-with-dietary-fructose-and-uric-acid-concentrations
#4
Valerio Nobili, Antonella Mosca, Rita De Vito, Massimiliano Raponi, Eleonora Scorletti, Christopher D Byrne
BACKGROUND & AIMS: As dietary components are delivered directly to the periportal zone of the liver lobule, there is the potential for greater injury in this zone (zone 1) compared to the perivenous zone (zone 3). We investigated the associations between dietary fructose consumption and uric acid concentrations and differential zonal injury in periportal and perivenous zones. METHODS: 271 children's histological images were scored in five periportal and five perivenous...
December 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29220382/anatomical-relationships-between-serotonin-5-ht2a-and-dopamine-d2-receptors-in-living-human-brain
#5
Tatsuya Ishii, Yasuyuki Kimura, Masanori Ichise, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Manabu Kubota, Ming-Rong Zhang, Makiko Yamada, Makoto Higuchi, Yoshinori Okubo, Tetsuya Suhara
METHODS: Seven healthy volunteers underwent PET scans with [18F]altanserin and [11C]FLB 457 for 5-HT2A and D2 receptors, respectively. As a measure of receptor density, a binding potential (BP) was calculated from PET data for 76 cerebral cortical regions. A correlation matrix was calculated between the binding potentials of [18F]altanserin and [11C]FLB 457 for those regions. The regional relationships were investigated using a bicluster analysis of the correlation matrix with an iterative signature algorithm...
2017: PloS One
https://www.readbyqxmd.com/read/29219888/computed-tomography-features-associated-with-the-eighth-edition-tnm-stage-classification-for-thymic-epithelial-tumors
#6
Sukhmani K Padda, Donato Terrone, Lu Tian, Amanda Khuong, Joel W Neal, Jonathan W Riess, Mark F Berry, Chuong D Hoang, Bryan M Burt, Ann N Leung, Erich J Schwartz, Joseph B Shrager, Heather A Wakelee
PURPOSE: The eighth edition of the TNM classification of malignant tumors for the first time includes an official staging system for thymic epithelial tumors (TETs) recognized by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC). Staging is critical for the management of TETs, and determining stage accurately from imaging has the potential to improve clinical outcomes. We examine preoperative computed tomography (CT) characteristics of TETs associated with AJCC/UICC pathologic TNM stage...
December 6, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29214728/disruption-of-network-for-visual-perception-of-natural-motion-in-primary-dystonia
#7
Koji Fujita, Wataru Sako, An Vo, Susan B Bressman, David Eidelberg
In healthy subjects, brain activation in motor regions is greater during the visual perception of "natural" target motion, which complies with the two-thirds power law, than of "unnatural" motion, which does not. It is unknown whether motion perception is normally mediated by a specific network that can be altered in the setting of disease. We used block-design functional magnetic resonance imaging and covariance analysis to identify normal network topographies activated in response to "natural" versus "unnatural" motion...
December 6, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29213014/a-case-of-a-giant-mass-in-the-lumbar-region-of-a-newborn-calf
#8
Kazuki Yoshioka, Aika Ishikawa, Makoto Sugiyama, Jun Nagasao, Motohiro Kikuchi
The present report describes a newborn calf with spina bifida that presented with a giant mass of the lumbar region, as well as subsequent gross, histological, and immunohistochemical examinations. A malformed Japanese black calf (estimated weight = 20 kg) was euthanized immediately after birth. A gross evaluation revealed a giant mass (approximately 60 cm × 30 cm × 15 cm) covered by the hair coat in the lumbar region and connected with the hair coat of the trunk. The mass surface was divided by a deep polygonal groove and externally resembled a lobulated kidney...
2017: Okajimas Folia Anatomica Japonica
https://www.readbyqxmd.com/read/29209979/genotoxicity-assessment-of-raw-and-treated-water-samples-using-allium-cepa-assay-evidence-from-perak-river-malaysia
#9
Amirhossein Malakahmad, Teh Sabariah Binti Abd Manan, Subarna Sivapalan, Taimur Khan
Allium cepa assay was carried out in this study to evaluate genotoxic effects of raw and treated water samples from Perak River in Perak state, Malaysia. Samples were collected from three surface water treatment plants along the river, namely WTPP, WTPS, and WTPK. Initially, triplicates of equal size Allium cepa (onions) bulbs, 25-30 mm in diameter and average weight of 20 g, were set up in distilled water for 24 h at 20 ± 2 °C and protected from direct sunlight, to let the roots to grow. After germination of roots (0...
December 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29209202/neural-basis-of-enhanced-executive-function-in-older-video-game-players-an-fmri-study
#10
Ping Wang, Xing-Ting Zhu, Zhigang Qi, Silin Huang, Hui-Jie Li
Video games have been found to have positive influences on executive function in older adults; however, the underlying neural basis of the benefits from video games has been unclear. Adopting a task-based functional magnetic resonance imaging (fMRI) study targeted at the flanker task, the present study aims to explore the neural basis of the improved executive function in older adults with video game experiences. Twenty video game players (VGPs) and twenty non-video game players (NVGPs) of 60 years of age or older participated in the present study, and there are no significant differences in age (t = 0...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29209186/the-neural-association-between-tendency-to-forgive-and-spontaneous-brain-activity-in-healthy-young-adults
#11
Haijiang Li, Jiamei Lu
The tendency to forgive (TTF) refers to one's global dispositional level of forgiveness across situations and relationships. Previous brain imaging studies examined activation patterns underlying forgiving process, yet the association between individual differences in the TTF and spontaneous brain activity at resting-state remains unknown. In this study, resting-state functional magnetic resonance imaging (fMRI) was used to investigate the correlation between the TTF and spontaneous brain activity in a young adult sample...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29205671/fronto-parietal-coding-of-goal-directed-actions-performed-by-artificial-agents
#12
Aleksandra Kupferberg, Marco Iacoboni, Virginia Flanagin, Markus Huber, Anna Kasparbauer, Thomas Baumgartner, Gregor Hasler, Florian Schmidt, Christoph Borst, Stefan Glasauer
With advances in technology, artificial agents such as humanoid robots will soon become a part of our daily lives. For safe and intuitive collaboration, it is important to understand the goals behind their motor actions. In humans, this process is mediated by changes in activity in fronto-parietal brain areas. The extent to which these areas are activated when observing artificial agents indicates the naturalness and easiness of interaction. Previous studies indicated that fronto-parietal activity does not depend on whether the agent is human or artificial...
December 5, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29205342/phylogenetic-analyses-of-the-hepatic-architecture-in-vertebrates
#13
Nobuyoshi Shiojiri, Harunobu Kametani, Noriaki Ota, Yusuke Akai, Tomokazu Fukuchi, Tomoka Abo, Sho Tanaka, Junri Sekiguchi, Sachie Matsubara, Hayato Kawakami
The mammalian liver has a structural and functional unit called the liver lobule, in the periphery of which the portal triad consisting of the portal vein, bile duct and hepatic artery is developed. This type of hepatic architecture is detectable in many other vertebrates, including amphibians and birds, whereas intrahepatic bile ducts run independently of portal vein distribution in actinopterygians such as the salmon and tilapia. It remains to be clarified how the hepatic architectures are phylogenetically developed among vertebrates...
December 4, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29201639/visual-feedback-alters-force-control-and-functional-activity-in-the-visuomotor-network-after-stroke
#14
Derek B Archer, Nyeonju Kang, Gaurav Misra, Shannon Marble, Carolynn Patten, Stephen A Coombes
Modulating visual feedback may be a viable option to improve motor function after stroke, but the neurophysiological basis for this improvement is not clear. Visual gain can be manipulated by increasing or decreasing the spatial amplitude of an error signal. Here, we combined a unilateral visually guided grip force task with functional MRI to understand how changes in the gain of visual feedback alter brain activity in the chronic phase after stroke. Analyses focused on brain activation when force was produced by the most impaired hand of the stroke group as compared to the non-dominant hand of the control group...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29201543/object-words-modulate-the-activity-of-the-mirror-neuron-system-during-action-imitation
#15
Haiyan Wu, Honghong Tang, Yue Ge, Suyong Yang, Xiaoqin Mai, Yue-Jia Luo, Chao Liu
Background: Although research has demonstrated that the mirror neuron system (MNS) plays a crucial role in both action imitation and action-related semantic processing, whether action-related words can inversely modulate the MNS activity remains unclear. Methods: Here, three types of task-irrelevant words (body parts, verbs, and manufactured objects) were presented to examine the modulation effect of these words on the MNS activity during action observation and imitation...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29201529/a-rare-case-of-lobulated-complete-renal-fusion-with-multiple-hila-and-vasculature
#16
L C Prasanna, Aparna Varma, Huban R Thomas, Antony Sylvan Dsouza
Complete renal fusion without crossed renal ectopia denotes the medial fusion of the renal parenchyma (with or without changes in the microarchitecture) in the pelvis with anteriorly placed short ureters terminating into the bladder. This could be due to the failure of renal analgen to ascent, lateral migration, axial rotation, and persistence of primitive vascular supply. Though remain asymptomatic such cases warrant concomitant congenital anomalies of other organ systems as well as the microarchitecture changes in the renal parenchyma...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29200772/sclerema-neonatorum-in-a-full-term-infant-showing-favorable-prognosis
#17
Seh Hyun Park, Soo-Chan Kim
Sclerema neonatorum (SN) is a rare disease characterized by firm, indurated, waxy skin lesions extending throughout the body, sparing the fat-free soles, palms, and genitalia. The prognosis of SN is generally very poor, with a high fatality rate. We report the case of a full-term infant with delayed onset of SN showing good prognosis. A 4-month-old Korean male infant presented with diffuse waxy, sclerotic skin lesions on the whole body, sparing the face, nipples, and genital area, which began developing at 2 months of age...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29200693/pilomatrix-carcinoma-masquerading-as-breast-carcinoma
#18
Trupti Pai, Shweta R Harwani, Asawari Patil, Ayushi Sahay, Tanuja Shet, Vani Parmar, Tabassum Wadasadawala, Sangeeta B Desai
Pilomatrix carcinoma is an exceedingly rare skin adnexal neoplasm derived from piliferous follicles, usually occurring in the head and neck region. Localization of this tumor in the breast is a rarity. We now report an unusual case of a 49-year-old female who presented with a palpable mass in the left breast for 2 years. Mammogram revealed a large, lobulated opacity with calcification, and positron emission tomography-computed tomography showed a metabolically active soft tissue mass measuring 15 cm involving all the quadrants of the left breast...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29199507/asymmetric-oculomotor-apraxia-optic-ataxia-and-simultanagnosia-with-right-hemispatial-neglect-from-a-predominantly-left-sided-lesion-of-the-parieto-occipital-area
#19
Yasuhisa Sakurai, Masanori Fujimoto, Kensuke Hamada, Izumi Sugimoto
INTRODUCTION: Bálint's syndrome involves bilateral damage to the parieto-occipital area. The extent of the effect of unilateral damage on the Bálint's triad (oculomotor apraxia, optic ataxia, and simultanagnosia) remains unknown. METHODS: We examined a 63-year-old, right-handed woman who developed right hemianopia, oculomotor apraxia, optic ataxia, simultanagnosia, and hemispatial neglect (HSN) for the right after a cerebral infarction, with detailed neuropsychological tests, magnetic resonance imaging, and single photon emission computed tomography (SPECT)...
December 2, 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29197003/ex-vivo-dual-perfusion-of-the-human-placenta-disease-simulation-therapeutic-pharmacokinetics-and-analysis-of-off-target-effects
#20
Paul Brownbill, Neil Sebire, Erin V McGillick, Stacey Ellery, Padma Murthi
In recent years ex vivo dual perfusion of the human placental lobule is seeing an international renaissance in its application to understanding fetal health and development. Here, we discuss the methods and uses of this technique in the evaluation of (1) vascular function, (2) transplacental clearance, (3) hemodynamic and oxygenation changes associated with pregnancy complications on placental structure and function, and (4) placental toxicology and post-perfusion evaluation of tissue architecture.
2018: Methods in Molecular Biology
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