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https://www.readbyqxmd.com/read/28916501/awakenings-in-rats-by-ultrasounds-a-new-animal-model-for-paradoxical-kinesia
#1
Luan Castro Tonelli, Markus Wöhr, Rainer Schwarting, Liana Melo-Thomas
Paradoxical kinesia refers to a sudden transient ability of akinetic patients to perform motor tasks they are otherwise unable to perform. The mechanisms underlying this phenomenon are unknown due a paucity of valid animal models that faithfully reproduce paradoxical kinesia. Here, in a first experiment, we present a new method to study paradoxical kinesia by "awakening" cataleptic rats through presenting appetitive 50-kHz ultrasonic vocalizations (USV), which are typical for social situations with positive valence, like juvenile play or sexual encounters ("rat laughter")...
September 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28905976/cutaneous-alternariosis-in-an-immunocompromised-dog-successfully-treated-with-cold-plasma-and-cessation-of-immunosuppressive-medication
#2
Janine Classen, Berrett Dengler, Christoph J Klinger, Sonya V Bettenay, Volker Rickerts, Ralf S Mueller
A cutaneous infection with Alternaria spp. was diagnosed in a 2-year-old male intact Irish setter dog, presenting with multifocal papules, plaques and ulcerations involving all four distal limbs, shoulder blades, scrotum, pinnae and nasal mucous membranes. The dog had been treated for inflammatory bowel disease and lymphangiectasia with immunosuppressive doses of cyclosporine and prednisolone for approximately 3 months. The diagnosis was based on clinical signs, the demonstration of fungal elements within skin biopsies, deep fungal culture and fungal PCR from a formalin-fixed tissue specimen...
September 13, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28901591/evaluation-of-the-correlation-between-scoring-feline-allergic-dermatitis-and-feline-extent-and-severity-index-and-skin-hydration-in-atopic-cats
#3
Marcin P Szczepanik, Piotr M Wilkołek, Łukasz R Adamek, Marcin Zając, Marcin Gołyński, Wiesław Sitkowski, Iwona Taszkun
BACKGROUND: Evaluation of the severity of clinical signs of cats with allergic skin diseases has used two scoring systems: Scoring Feline Allergic Dermatitis (SCORFAD) and the Feline Extent and Severity Index (FeDESI). The integrity of the cutaneous barrier can also be evaluated by measuring skin hydration. A correlation between the clinical score and skin hydration has been observed in humans and dogs with atopic dermatitis (AD). HYPOTHESIS: To demonstrate a correlation between the clinical score and skin hydration of cats affected with presumed AD...
September 13, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28900387/social-isolation-in-early-versus-late-adolescent-mice-is-associated-with-persistent-behavioral-deficits-that-can-be-improved-by-neurosteroid-based-treatment
#4
Andrea Locci, Philippe Geoffroy, Michel Miesch, Ayikoe-Guy Mensah-Nyagan, Graziano Pinna
Early trauma and stress exposure during a critical period of life may increase the risk of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) in adulthood. The first-choice treatment for MDD and PTSD are selective serotonin reuptake inhibitor (SSRI) antidepressants. Unfortunately, half of MDD and PTSD patients show resistance to the therapeutic effects of these drugs and more efficient treatments are essential. Both MDD and PTSD patients present reduced levels of allopregnanolone (Allo), a potent endogenous positive allosteric modulator of GABA action at GABAA receptors which are normalized by SSRIs in treatment responders...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28900245/the-role-of-metronomic-capecitabine-for-treatment-of-recurrent-hepatocellular-carcinoma-after-liver-transplantation
#5
Matteo Ravaioli, Alessandro Cucchetti, Antonio Daniele Pinna, Vanessa De Pace, Flavia Neri, Maria Aurelia Barbera, Lorenzo Maroni, Giorgio Frega, Andrea Palloni, Stefania De Lorenzo, Maria Cristina Ripoli, Maria Abbondanza Pantaleo, Matteo Cescon, Massimo Del Gaudio, Giovanni Brandi
The management of recurrent hepatocellular carcinoma untreatable with surgical options is based on systemic therapy with sorafenib. Due to the high rates of adverse events connected to the therapy with sorafenib, metronomic capecitabine seems a promising strategy for these patients. We analyzed the data of 38 patients with hepatocellular carcinoma recurrent after liver transplantation performed at our center. We compared the outcome of 17 patients receiving metronomic capecitabine versus 20 patients experiencing best supportive care and versus the data of the literature about treatment with sorafenib...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28885986/estimation-of-baroreflex-sensitivity-by-the-bivariate-phase-rectified-signal-averaging-method-a-comparison-with-the-phenylephrine-method
#6
Roberto Maestri, Maria Teresa La Rovere, Grzegorz Raczak, Ludmiła Danilowicz-Szymanowicz, Gian Domenico Pinna
Background A novel technique to assess spontaneous baroreflex sensitivity (BRS) by bivariate phase-rectified signal averaging (PRSA-BRS) has been recently proposed and its independent prognostic power demonstrated. This method, however, has never been compared with the Phenyleprine test (Phe-BRS), commonly regarded as the reference method in clinical and research applications. Methods In 192 heart failure (HF) and 41 post-myocardial infarction (post-MI) patients we compared PRSA-BRS with Phe-BRS, assessing both association and agreement...
September 8, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28885508/defining-benchmarks-in-liver-transplantation-a-multicenter-outcome-analysis-determining-best-achievable-results
#7
Xavier Muller, Francesca Marcon, Gonzalo Sapisochin, Max Marquez, Federica Dondero, Michel Rayar, Majella M B Doyle, Lauren Callans, Jun Li, Greg Nowak, Marc-Antoine Allard, Ina Jochmans, Kyle Jacskon, Magali Chahdi Beltrame, Marjolein van Reeven, Samuele Iesari, Alessandro Cucchetti, Hemant Sharma, Roxane D Staiger, Dimitri A Raptis, Henrik Petrowsky, Michelle de Oliveira, Roberto Hernandez-Alejandro, Antonio D Pinna, Jan Lerut, Wojciech G Polak, Eduardo de Santibañes, Martín de Santibañes, Andrew M Cameron, Jacques Pirenne, Daniel Cherqui, René A Adam, Bö-Göran Ericzon, Bjoern Nashan, Kim Olthoff, Avi Shaked, William C Chapman, Karim Boudjema, Olivier Soubrane, Catherine Paugam-Burtz, Paul D Greig, David R Grant, Amanda Carvalheiro, Paolo Muiesan, Philipp Dutkowski, Milo Puhan, Pierre-Alain Clavien
OBJECTIVE: To propose benchmark outcome values in liver transplantation, serving as reference for assessing individual patients or any other patient groups. BACKGROUND: Best achievable results in liver transplantation, that is, benchmarks, are unknown. Consequently, outcome comparisons within or across centers over time remain speculative. METHODS: Out of 7492 liver transplantation performed in 17 international centers from 3 continents, we identified 2024 low risk adult cases with a laboratory model for end-stage liver disease score ≤20 points, a balance of risk score ≤9, and receiving a primary graft by donation after brain death...
September 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28881978/incorporating-interaction-networks-into-the-determination-of-functionally-related-hit-genes-in-genomic-experiments-with-markov-random-fields
#8
Sean Robinson, Jaakko Nevalainen, Guillaume Pinna, Anna Campalans, J Pablo Radicella, Laurent Guyon
Motivation: Incorporating gene interaction data into the identification of 'hit' genes in genomic experiments is a well-established approach leveraging the 'guilt by association' assumption to obtain a network based hit list of functionally related genes. We aim to develop a method to allow for multivariate gene scores and multiple hit labels in order to extend the analysis of genomic screening data within such an approach. Results: We propose a Markov random field-based method to achieve our aim and show that the particular advantages of our method compared with those currently used lead to new insights in previously analysed data as well as for our own motivating data...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28878689/a20-tnfaip3-discriminates-tumor-necrosis-factor-tnf-induced-nf-%C3%AE%C2%BAb-from-jnk-pathway-activation-in-hepatocytes
#9
Federico Pinna, Michaela Bissinger, Katharina Beuke, Nicolas Huber, Thomas Longerich, Ursula Kummer, Peter Schirmacher, Sven Sahle, Kai Breuhahn
In the liver tumor necrosis factor (TNF)-induced signaling critically regulates the immune response of non-parenchymal cells as well as proliferation and apoptosis of hepatocytes via activation of the NF-κB and JNK pathways. Especially, the induction of negative feedback regulators, such as IκBα and A20 is responsible for the dynamic and time-restricted response of these important pathways. However, the precise mechanisms responsible for different TNF-induced phenotypes under physiological stimulation conditions are not completely understood so far...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28870538/long-term-assessment-of-recruitment-early-stages-and-population-dynamics-of-the-endangered-mediterranean-fan-mussel-pinna-nobilis-in-the-columbretes-islands-nw-mediterranean
#10
Diego K Kersting, José R García-March
A long-term experimental approach was undertaken to assess viability and resilience of the endangered Mediterranean fan mussel Pinna nobilis. Artificial and natural recruitment, mortality, population traits and juvenile growth were assessed in seasonal and annual surveys. In the Columbretes Islands, P. nobilis thrives in differing substrate types, from coarse sand to boulders, in Cymodocea nodosa meadows and among rhodoliths, and is always found sharing habitat with the less abundant sibling species P. rudis...
August 19, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28842941/characterization-of-early-communicative-behavior-in-mouse-models-of-neurofibromatosis-type-1
#11
Susan E Maloney, Krystal C Chandler, Corina Anastasaki, Michael A Rieger, David H Gutmann, Joseph D Dougherty
Neurofibromatosis type 1 (NF1) is a monogenic neurodevelopmental disease caused by germline loss-of-function mutations in the NF1 tumor suppressor gene. Cognitive impairments are observed in approximately 80% of children with this disease, with 45-60% exhibiting autism spectrum disorder (ASD) symptomatology. In light of the high comorbidity rate between ASD and NF1, we assessed early communicative behavior by maternal-separation induced pup ultrasonic vocalizations (USV) and developmental milestones in two distinct Nf1 genetically engineered models, one modeling clinical germline heterozygous loss of Nf1 function (Nf1(+/-) mice), and a second with somatic biallelic Nf1 inactivation in neuroglial progenitor cells (Nf1(GFAP) CKO mice)...
August 26, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28834974/-a-painful-nodule-of-the-pinna
#12
Ioannis Kastanioudakis, Panagiotis Saravakos, Oliver Reichel, Nafsika Ziavra
No abstract text is available yet for this article.
August 23, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28830578/characterization-of-demodex-musculi-infestation-associated-comorbidities-and-topographic-distribution-in-a-mouse-strain-with-defective-adaptive-immunity
#13
Melissa A Nashat, Kerith R Luchins, Michelle L Lepherd, Elyn R Riedel, Joanna N Izdebska, Neil S Lipman
A colony of B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest (TRP1/TCR) mice presented with ocular lesions and ulcerative dermatitis. Histopathology, skin scrapes, and fur plucks confirmed the presence of Demodex spp. in all clinically affected and subclinical TRP1/TCR mice examined (n = 48). Pasteurella pneumotropica and Corynebacterium bovis, both opportunistic pathogens, were cultured from the ocular lesions and skin, respectively, and bacteria were observed microscopically in abscesses at various anatomic locations (including retroorbital sites, tympanic bullae, lymph nodes, and reproductive organs) as well as the affected epidermis...
August 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28827336/asymmetries-in-behavioral-and-neural-responses-to-spectral-cues-demonstrate-the-generality-of-auditory-looming-bias
#14
Robert Baumgartner, Darrin K Reed, Brigitta Tóth, Virginia Best, Piotr Majdak, H Steven Colburn, Barbara Shinn-Cunningham
Studies of auditory looming bias have shown that sources increasing in intensity are more salient than sources decreasing in intensity. Researchers have argued that listeners are more sensitive to approaching sounds compared with receding sounds, reflecting an evolutionary pressure. However, these studies only manipulated overall sound intensity; therefore, it is unclear whether looming bias is truly a perceptual bias for changes in source distance, or only in sound intensity. Here we demonstrate both behavioral and neural correlates of looming bias without manipulating overall sound intensity...
August 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28814407/fungal-endophyte-communities-in-the-temperate-fern-polystichum-munitum-show-early-colonization-and-extensive-temporal-turnover
#15
Brett S Younginger, Daniel J Ballhorn
PREMISE OF THE STUDY: Fungal endophytes have been shown to colonize all land plants, yet surprisingly little attention has been given to their community composition in ferns. We examined the diversity and temporal turnover of fungal endophytes in foliar tissue of the temperate western sword fern, Polystichum munitum, comparing taxa in newly emerged leaflets and in the same fronds after 1 mo of exposure in the field. METHODS: Utilizing next-generation sequencing, we sampled pinnae from P...
August 16, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28794961/feline-cutaneous-histoplasmosis-the-first-case-report-from-thailand
#16
L Larsuprom, L Duangkaew, C Kasorndorkbua, C Chen, A Chindamporn, N Worasilchai
A 2-year-old, neutered female domestic shorthaired cat presented with a history of multiple papules and nodules on pinnae, nodules on the nose, and chronic wound at the lateral surface of left radial area for four months. Skin biopsy demonstrated moderate numbers of small, oval-to-round, single-walled yeasts inside the macrophages. In addition, PCR confirmed the sequence of Histoplasma capsulatum. This is the first case report of feline cutaneous histoplasmosis in Thailand.
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28770691/outbreak-of-salmonella-enteritidis-phage-type-1b-associated-with-frozen-pre-cooked-chicken-cubes-finland-2012
#17
S Huusko, A Pihlajasaari, S Salmenlinna, J Sõgel, I Dontšenko, E DE Pinna, H Lundström, S Toikkanen, R Rimhanen-Finne
In August to October 2012, a nationwide outbreak of Salmonella enteritidis phase type (PT) 1B with 53 cases occurred in Finland. Hypothesis generating interviews pointed toward ready-to-eat chicken salad from a Finnish company and at the same time Estonian authorities informed of a S. enteritidis PT 1B outbreak linked to chicken wrap prepared at an Estonian restaurant. We found that chicken salad was associated with the infection (odds ratio (OR) 16·1, 95% confidence interval (CI) 1·7-148·7 for consumption and OR 17·5...
August 3, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28770644/the-combined-effect-of-sango-sprout-juice-and-caloric-restriction-on-metabolic-disorders-and-gut-microbiota-composition-in-an-obesity-model
#18
Fabio Vivarelli, Donatella Canistro, Clara Babot Marquillas, Silvia Cirillo, Gina R De Nicola, Renato Iori, Giacomo Biagi, Carlo Pinna, Fabio Gentilini, Luisa Pozzo, Vincenzo Longo, Moreno Paolini
The main purpose of this study was to compare the benefits of SSJ supplementation in obese rats with those achieved only by switching the alimentary regimen from high-fat (HFD) to the regular one (RD) in liver, ileum and prostate. Furthermore, changings in caecal chime microbiota were investigated. SSJ was administered to rats in combination with a RD (HFD-RD + SSJ). The switch from HFD to RD led to a weight loss of almost 9.8 g, and the total cholesterol was found to be significantly lower. In the HFD-RD + SSJ group, all values were improved compared with the HFD control, and the weight decrement was higher (-23...
August 3, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28761845/angiolymphoid-hyperplasia-with-eosinophilia-and-its-response-to-the-combination-of-radiofrequency-ablation-and-topical-timolol
#19
Pooja Arora, Neha Meena, Prafulla K Sharma, Minakshi Bhardwaj
Angiolymphoid hyperplasia with eosinophilia is a rare vascular disease characterized by multiple erythematous to violaceous papules, commonly present on the head and neck region. We report a case of a 23-year-old female who presented with multiple, erythematous asymptomatic papules on the preauricular region and pinna, which on biopsy was suggestive of angiolymphoid hyperplasia. The lesions were treated with a novel combination of radiofrequency ablation and topical timolol. The lesions healed without scarring and there was no recurrence on 1 year follow up...
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28758797/an-in-vitro-evaluation-of-the-effects-of-a-yucca-schidigera-extract-and-chestnut-tannins-on-composition-and-metabolic-profiles-of-canine-and-feline-faecal-microbiota
#20
Carlo Pinna, Carla Giuditta Vecchiato, Vladimiro Cardenia, Maria Teresa Rodriguez-Estrada, Claudio Stefanelli, Monica Grandi, Pier Paolo Gatta, Giacomo Biagi
The in vitro effect of a Yucca schidigera extract (YSE) and tannins from chestnut wood on composition and metabolic activity of canine and feline faecal microbiota was evaluated. Four treatments were carried out: control diet, chestnut tannins (CT), YSE and CT + YSE. The YSE was added to canine and feline faecal cultures at 0.1 g/l, while CT were added at 0.3 g/l for a 24-h incubation. A total of 130 volatile compounds were detected by means of headspace-solid phase microextraction gas-chromatography/mass spectrometry analyses...
July 31, 2017: Archives of Animal Nutrition
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