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https://www.readbyqxmd.com/read/27910822/prolonged-in-vitro-precultivation-alleviates-post-implantation-inflammation-and-promotes-stable-subcutaneous-cartilage-formation-in-a-goat-model
#1
Yi Liu, Dan Li, Zongqi Yin, Xusong Luo, Wei Liu, Wenjie Zhang, Zhiyong Zhang, Yilin Cao, Yu Liu, Guangdong Zhou
Synthetic biodegradable scaffolds such as polylactic acid coated polyglycolic acid (PLA-PGA) are especially suitable for engineering shaped cartilage such as auricle, but they induce a serious inflammatory reaction particularly in the immunologically aggressive subcutaneous site, leading to resorption of the engineered autologous cartilage. Our previous study in a rabbit model has demonstrated 2 weeks of in vitro precultivation could significantly alleviate the post-implantation inflammation induced by PLA-PGA engineered cartilaginous grafts, but reproduction of this result failed in a preclinical goat model...
December 2, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27899950/bone-anchored-titanium-implants-in-patients-with-auricular-defects-three-years-and-27-patients-experience
#2
Emilio Mevio, Luca Facca, Stefano Schettini, Mauro Mullace
Different surgical solutions have been proposed for reconstruction of the auricle following loss of the pinna through traumatic injury or neoplastic disease or in patients with congenital defects. Surgical treatment may involve the insertion of an autogenous rib cartilage framework or the use of a porous polymer material inserted into an expanded postauricular flap. Reconstruction with rib cartilage has yielded good results but requires more than one surgical step, and adverse events can occur both at the donor and at the acceptor site; cases of prosthesis rejection have also been described following application of the polymeric prosthesis...
2016: International Journal of Otolaryngology
https://www.readbyqxmd.com/read/27898202/optimization-of-transcutaneous-vagus-nerve-stimulation-using-functional-mri
#3
Natalia Yakunina, Sam Soo Kim, Eui-Cheol Nam
OBJECTIVE/HYPOTHESIS: Vagus nerve stimulation (VNS) is an established therapy for drug-resistant epilepsy, depression, and a number of other disorders. Transcutaneous stimulation of the auricular branch of the vagus nerve (tVNS) has been considered as a non-invasive alternative. Several functional magnetic resonance imaging (fMRI) studies on the effects of tVNS used different stimulation parameters and locations in the ear, which makes it difficult to determine the optimal tVNS methodology...
November 29, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27896180/correction-of-congenital-auricular-deformities-using-the-ear-molding-technique
#4
Taeyong Woo, Young Seok Kim, Tai Suk Roh, Dae Hyun Lew, In Sik Yun
BACKGROUND: Studies of the ear-molding technique have emphasized the importance of initiating molding early to achieve the best results. In the present study, we describe the immediate effects and long-term outcomes of this technique, focusing on children who were older than the ideal age of treatment initiation. METHODS: Patients who visited our institution from July 2014 to November 2015 were included. Medical charts were reviewed to collect data on demographics, the duration of treatment, the types of deformities, and the manner of recognition of the deformity and referral to our institution...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27888895/treating-scars-in-the-auricle-region
#5
REVIEW
Deborah Watson, Bharat Panuganti
This article provides a review of the surgical and nonsurgical options available to manage a variety of auricular scars. The basics of wound healing are discussed in addition to the etiology of keloids and the cauliflower ear. Many auricular scars can be revised with scar excision techniques, but separate discussions for the treatment of keloids and the cauliflower ear are provided. The management plan for auricular scarring requires appropriate patient counseling regarding the risk of recurrence in keloids, regrowth of scar tissue in cauliflower ears, scar hypertrophy at the line of closure, widening of the scar, and persisting ear contour deformities...
February 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/27834100/sound-lateralization-ability-of-patients-with-bilateral-microtia-and-atresia-after-bilateral-reconstruction-of-auricles-and-external-auditory-canals-and-fitting-of-new-canal-type-hearing-aids-to-replace-a-bone-conduction-hearing-aid
#6
Kimitaka Kaga, Hirotaka Asato
CONCLUSION: Each of eight patients with bilateral microtia and atresia underwent bilateral reconstruction of the auricles and external auditory canals and were fitted bilateral canal-type hearing aids in the operated ears to replace a bone conduction hearing aid. The ability to discriminate inter-aural intensity difference (IID) and even inter-aural time difference (ITD) was retained in all these patients. OBJECTIVE: This study studied the post-operative sound lateralization ability of patients with bilateral microtia and atresia after total reconstruction of both auricles and external auditory canals, followed by fitting of bilateral canal-type hearing aids...
November 11, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27807997/adenosine-receptors-expression-in-cardiac-fibroblasts-of-patients-with-left-ventricular-dysfunction-due-to-valvular-disease
#7
Silvia Del Ry, Manuela Cabiati, Veronica Della Latta, Stefania Zimbone, Mariarita Natale, Pietro Enea Lazzerini, Francesco Diciolla, Pier Leopoldo Capecchi, Franco Laghi-Pasini, Maria Aurora Morales
CONTEXT: Adenosine restores tissue homeostasis through the interaction with its membrane receptors (AR) expressed on fibroblasts, endothelial cells, smooth muscle cells and leukocytes, but their modulation is still not fully understood. OBJECTIVE: To evaluate whether changes in the transcriptomic profiling of adenosine receptors (AR) occur in cardiac fibroblasts (CF) of patients (pts) with LV dysfunction due to valvular disease (V). The secondary aim was to compare in the same pts the results obtained at cardiac level with those found in circulating leukocytes...
November 3, 2016: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/27765391/fabrication-of-postsurgical-auricle-separator-stent-in-reconstruction-of-the-ear
#8
Kumar C Pradeep, Shahid M A Mohammed, Mandavia Anisha
A natural appearing ear with appropriate projection from the head remains a great challenge in the reconstruction of the ear. Surgical and prosthetic means have been addressed in the management of patients with microtia, with each carrying its own merits and demerits. Lack of adequate projection of the ear and adhesion of tissues are some common complications of reconstructive surgery that can adversely affect the treatment outcome. This article describes a technique for the fabrication of a postsurgical stent to prevent adhesion of the surgically reconstructed ear to the underlying tissues...
October 17, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27755445/nasal-reconstruction-and-repair-of-secondary-nasal-deformities-following-treatment-of-nasal-hemangiomas
#9
Xiaona Lu, Fei Fan, Huan Wang, Jianjun You
BACKGROUND: Secondary nasal deformities and retardation of development due to treatment of nasal hemangioma during infancy are a challenge when it comes to nasal reconstruction. In order to evaluate nasal repair and reconstruction in these patients, the authors compared the ease and outcomes of using expanded forehead, nasolabial sulcus, and medial upper arm tube flaps. METHODS: According to the deformities and patients' wishes, flaps were selected; using autogeneic rib cartilage, auricle cartilage, or silica gel as a scaffold or without framework; the inner lining were made by the residual scar tissue or the distal end of transferred flap...
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27755426/bone-marrow-stem-cells-and-ear-framework-reconstruction
#10
Hamid Karimi, Seyed-Abolhassan Emami, Mohammad-Kazem Olad-Gubad
BACKGROUND: Repair of total human ear loss or congenital lack of ears is one of the challenging issues in plastic and reconstructive surgery. OBJECTIVE: The aim of the present study was 3D reconstruction of the human ear with cadaveric ear cartilages seeded with human mesenchymal stem cells. METHOD: We used cadaveric ear cartilages with preserved perichondrium. The samples were divided into 2 groups: group A (cartilage alone) and group B (cartilage seeded with a mixture of fibrin powder and mesenchymal stem cell [1,000,000 cells/cm] used and implanted in back of 10 athymic rats)...
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27746605/prosthetic-management-of-posttraumatic-external-auditory-canal-atresia-a-rare-cause-of-conductive-hearing-loss
#11
A R Adhershitha, S Anilkumar, C Rajesh, Deepak C Mohan
Acquired external auditory canal (EAC) atresia is an infrequent entity which can originate from a number of different causes including trauma, infection, neoplasia, inflammation, and radiotherapy. Posttraumatic atresias are exceptionally rare, only 10% of atresias are attributed to trauma in most of the series. The management of stenosis of the EAC is challenging as it is associated with residual hearing loss and late recurrence. Traditional stents often occlude the EAC, resulting in a temporary conductive hearing loss...
October 2016: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/27741347/dermatofibroma-of-the-auricle
#12
Sameep Kadakia, Boris Chernobilsky, Codrin Iacob
An adolescent male presented to the office with a 3-month history of a small left ear mass located on the posterior helix. Although the patient was asymptomatic, the decision was made to remove the mass in the operating room and send for pathology. Following excision, the mass was stained and examined by the pathologist. Staining positive for Factor VIIIa and CD68, the lesion was also found to have a combination of histiocytes and fibroblastic spindle cells. The diagnosis of dermatofibroma, cellular type, was made and the patient required no further treatment...
October 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27737639/sex-differences-in-volume-overload-in-skinned-fibers
#13
C Bening, K Hamouda, R Leyh
BACKGROUND: The impact of sex on cardiac morphology and function in chronic volume overload has been described in detail. However, the relation between sex and contractile properties at the actin-myosin level has not been well defined. Therefore, we evaluated the influence of sex on the contractile capacities of patients with chronic volume overload. METHODS: In 36 patients (18 males, 65 ± 9 years; 18 females, 65 ± 13 years) scheduled for elective mitral valve surgery due to severe mitral regurgitation (MR) with preserved left ventricular function, right auricle samples were obtained prior to extracorporal circulation...
October 14, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27729135/mastoid-fascia-kite-flap-for-cryptotia-correction
#14
François Simon, Charlotte Celerier, Erea-Noël Garabedian, Françoise Denoyelle
OBJECTIVE: Cryptotia is one of the most common malformations of the upper auricle with aesthetic and functional consequences, however there is no standard treatment. We present the surgical technique and results of a kite flap procedure which can be used in the different cryptotia subtypes. METHODS: We reviewed all patients treated in our department from 2010 to 2015, using a mastoid fascia kite flap technique. The incision of this local flap follows the retro-auricular sulcus along the rim of the helix superiorly and drawing a skin paddle inferiorly...
November 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27726131/reevaluation-of-the-arterial-blood-supply-of-the-auricle
#15
Isaac Zilinsky, Detlev Erdmann, Oren Weissman, Niels Hammer, Mircea-Constantin Sora, Thilo L Schenck, Sebastian Cotofana
The anatomical basis for auricular flaps used in multiple aesthetic and reconstructive procedures is currently based on a random distribution of the underlying arterial network. However, recent findings reveal a systematic pattern as opposed to the present concepts. Therefore, we designed this study to assess the arterial vascular pattern of the auricle in order to provide reliable data about the vascular map required for surgical interventions. Sixteen human auricles from eight body donors (five females/three males, 84...
October 11, 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27717980/quantitative-analysis-of-the-right-auricle-with-256-slice-computed-tomography
#16
Cai-Ying Li, Bu-Lang Gao, Tong Pan, Cheng Xiang, Xue-Jing Zhang, Xiao-Wei Liu, Qiong-Ying Fan
PURPOSE: To quantitatively measure the morphology parameters of the right auricle with 256-slice multidetector computed tomography angiography (MDCTA) in healthy people. MATERIALS AND METHODS: A retrospective analysis of 200 patients who had undergone coronary MDCTA with negative findings was performed. The raw imaging data were reconstructed and the right auricular volume, right atrial volume, right auricle height, base long and short axes, base perimeter and area, normal angle, and distance were quantitatively measured...
October 7, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27714497/mechanisms-of-ear-trauma-and-reconstructive-techniques-in-105-consecutive-patients
#17
Michail N Kolodzynski, Moshe Kon, Silvan Egger, Corstiaan C Breugem
Acquired auricular deformities may diminish facial esthetics and cause psychological distress. The aim of this article is to provide an overview of the type of injuries and applied reconstructive techniques in a large academic hospital in The Netherlands. A retrospective chart review was conducted for the last 105 patients who underwent auricular reconstruction for an acquired deformity. Data concerning gender, affected side, cause of injury, anatomical region, the previous and further surgeries, type of cartilage, and skin cover used were collected and analyzed...
October 6, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27709295/topically-applied-manganese-porphyrins-bmx-001-and-bmx-010-display-a-significant-anti-inflammatory-response-in-a-mouse-model-of-allergic-dermatitis
#18
Kelsey Stover, Tomoki Fukuyama, Ashlyn T Young, Michael A Daniele, Rebecca Oberley, James D Crapo, Wolfgang Bäumer
In this study, we topically administered two antioxidant compounds, the manganese-porphyrin-derivatives BMX-001 and BMX-010, in a mouse model of allergic dermatitis and compared the efficacy for reduction of itch and inflammation. In vitro effects of BMX-001 and BMX-010 on keratinocytes, bone marrow derived dendritic cells (BMDCs) and T-cells were initially analysed. For assessment of scratching behaviour, BMX-001 and BMX-010 (0.01 and 0.1 %) were topically applied 16 h and/or 1 h before compound 48/80 or toluene-2,4,-diisocyanate (TDI) challenge in a TDI induced mouse dermatitis model...
October 5, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27703821/external-otitis-an-unusual-presentation-in-neonates
#19
Peymaneh Alizadeh Taheri, Shima Rostami, Manelie Sadeghi
Acute otitis externa (AOE) is an infection of the external auditory canal, the auricle, and the outer surface of the tympanic membrane. Although AOE is one of the most common otologic conditions encountered in pediatric population, it is known to primarily affect children older than 2 years. We report a case of AOE caused by Staphylococcus aureus in a 23-day-old neonate. A 23-day-old female infant presented to our neonatology clinic with irritability and discharge from the right ear. There were yellow otorrhea, mild erythema, and edema of right external ear canal...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27703406/autopsy-imaging-for-cardiac-tamponade-in-a-thoroughbred-foal
#20
Kazutaka Yamada, Fumio Sato, Noriyuki Horiuchi, Tohru Higuchi, Yoshiyasu Kobayashi, Naoki Sasaki, Yasuo Nambo
Autopsy imaging (Ai), postmortem imaging before necropsy, is used in human forensic medicine. Ai was performed using computed tomography (CT) for a 1-month-old Thoroughbred foal cadaver found in a pasture. CT revealed pericardial effusion, collapse of the aorta, bleeding in the lung lobe, gas in the ventricles and liver parenchyma, and distension of the digestive tract. Rupture in the left auricle was confirmed by necropsy; however, it was not depicted on CT. Therefore, Ai and conventional necropsy are considered to complement each other...
2016: Journal of Equine Science
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