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Paolo Pavone, Noemi Giustini, Caterina Fimiani, Francesca Paoletti, Mario Falciano, Alessandra Salotti, Fiorella Di Sora, Samir Al Moghazi, Ivano Mezzaroma, Vincenzo Vullo, Gabriella d'Ettorre
BACKGROUND: Raltegravir (RAL) is considered one of the better-tolerated antiretroviral medications, due to limited side effects and minimal drug-drug interactions. Matherials and Methods: We retrospectively evaluated 96 HIV+, over 60 years old, experienced patients who had switched from any antiretroviral drug to raltegravir-based nuc-sparing or standard nucleoside-backbone regimens. A control group with patients aged under 60 years old was included. RESULTS: The median age of the patients was 66 years (IQR 10...
November 23, 2017: Current HIV Research
Marina C Dos Santos Moreira, Izabella S de Jesus Pinto, Aline A Mourão, James O Fajemiroye, Eduardo Colombari, Ângela A da Silva Reis, André H Freiria-Oliveira, Marcos L Ferreira-Neto, Gustavo R Pedrino
The metabolic syndrome (MS), formally known as syndrome X, is a clustering of several risk factors such as obesity, hypertension, insulin resistance, and dislypidemia which could lead to the development of diabetes and cardiovascular diseases (CVD). The frequent changes in the definition and diagnostic criteria of MS are indications of the controversy and the challenges surrounding the understanding of this syndrome among researchers. Obesity and insulin resistance are leading risk factors of MS. Moreover, obesity and hypertension are closely associated to the increase and aggravation of oxidative stress...
2015: Frontiers in Physiology
Renato de Souza Abboud, Vivian Alves Pereira, Carlos Alberto Soares da Costa, Gilson Teles Boaventura, Mauricio Alves Chagas
INTRODUCTION: the abuse of steroid hormones administered in chronic form may cause alterations in the lypidic profile, conveying na increase in the levels of LDL, and reduction in the levels of HDL. In average, 53.44% of the lypidic composition of the avocado core is composed of oleic acid (which is a phytosterol) and the study of the hypolipemiating effect of these substances has been performed aiming at the prevention and control of dislypidemias. OBJECTIVE: to assess the potential hypolipemiant power of the avocado oil on the lypidogram of adult male Wistar rats submitted to prolonged androgenic hiperestimulation...
August 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Carlota Recio, Ainhoa Oguiza, Iolanda Lazaro, Beñat Mallavia, Jesus Egido, Carmen Gomez-Guerrero
OBJECTIVE: Activation of Janus kinase/signal transducers and activators of transcription (STAT) pathway by hyperglycemia and dislypidemia contributes to the progression of diabetic complications, including atherosclerosis. Suppressor of cytokine signaling (SOCS) proteins negatively regulate Janus kinase/STAT and have emerged as promising target for anti-inflammatory therapies. We investigated whether a cell-permeable lipopeptide corresponding to the kinase inhibitory region of SOCS1 could reduce atherosclerosis in diabetic mice and identified the mechanisms involved...
September 2014: Arteriosclerosis, Thrombosis, and Vascular Biology
Angel Rubín, Cristina Sánchez-Montes, Victoria Aguilera, Fernando San Juan, Isabel Ferrer, Angel Moya, Eva Montalva, Eugenia Pareja, Rafael López-Andujar, Martín Prieto, Marina Berenguer
There are few studies focusing on long-term complications in liver transplant (LT) recipients. The aim of this study was to define the outcome of LT recipients having survived at least 10 years from LT. Of 323 adult LT done between 1991 and 1997, the 167(52%) alive >10 years post-LT (baseline time) formed the study population. Long-term outcome measures included the following: immunosuppression, metabolic complications [obesity, arterial hypertension (AH), diabetes, dislypidemia], cardiovascular events (CVE), chronic renal dysfunction-CRD, and de novo tumors...
July 2013: Transplant International: Official Journal of the European Society for Organ Transplantation
Cecilia Zanin Palchetti, Rose Vega Patin, Aída de Fátima Thomé Barbosa Gouvêa, Vera Lúcia Szejnfeld, Regina Célia de Menezes Succi, Fernanda Luisa Ceragioli Oliveira
OBJECTIVE: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. METHODS: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Diseases - Universidade Federal de São Paulo, São Paulo city, Brazil, was carried out from August to December 2008. Age, clinical and immunological status, prophylaxis, transmission and highly active antiretroviral therapy were recorded...
January 2013: Brazilian Journal of Infectious Diseases
Alvaro L Ronco, Eduardo De Stefani, Hugo Deneo-Pellegrini, Aldo Quarneti
Obese postmenopausal women increase their risk of developing breast cancer (BC), in particular if they display an android-type pattern of adiposity, which is also associated to increased risks of diabetes mellitus, hypertension and cardiovascular disease. In order to explore the associations among anthropometry (body mass index, body composition, somatotype), some specific items of medical history (diabetes, hypertension, dislypidemias, hyperuricemia) and the risk of BC in Uruguayan women, a case-control study was carried out between 2004-2009 at our Oncology Unit...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
G Sur, M Sur, L Kudor-Szabadi, L Sur, D Sporis, D Sur
Hypertension represents a serious problem in Romania, as there are over 3 million hypertensive people in our country. There is a high incidence of deaths caused by hypertension.WE PERFORMED AN ANALYTICAL PROSPECTIVE STUDY THAT AIMS TO DETERMINE: prevalence of arterial hypertension in a population from Cluj county, distribution on age and gender, arterial hypertension severity, association of hypertension with other cardiovascular risk factors. Our study included 2266 patients, age 14 years old up to over 90 years old, both masculine and feminine gender, known with hypertension and new-diagnosed ones...
January 2010: Mædica
Matea Zajc Petranović, Tatjana Skarić-Jurić, Nina Smolej Narančić, Zeljka Tomas, Petra Krajačić, Jasna Miličić, Maja Barbalić, Spomenka Tomek-Roksandić
The human angiotensin converting enzyme (ACE) gene is one of the most investigated candidate genes for cardiovascular diseases (CVD), but the understanding of its role among the elderly is vague. Therefore, this study focuses at: (a) testing the association of ACE polymorphism with CVD risk factors among the elderly, and (b) detecting the possible unequal distribution of ACE genotypes between senescent and younger segments of the European populations. The association of ACE I/D polymorphism with CVD health status [hypertension (HT), obesity, dislypidemia] in 301 very old subjects (88...
June 2012: Age (2005-)
Luciana Mucci, Francesca Santilli, Chiara Cuccurullo, Giovanni Davì
Soft drinks and sugar-sweetened beverages have been targeted as one of the primary culprits in the escalating rates of obesity and diabetes and reduction of added sugars is considered between the goals to achieve in order to promote cardiovascular health and to reduce deaths from cardiovascular causes. Many reliable mechanisms, such as dislypidemia, inflammation and enhanced oxidative stress, have been proposed to support a causal link between sugar sweetened beverages intake and cardiovascular risk, but the ultimate underlying pathways remain to be determined in adequately designed studies...
August 2012: Internal and Emergency Medicine
Lucreţia Anghel, Rodica Ghiuru, Cristina-Maria Gavrilescu
UNLABELLED: The aim of the study was to evaluate dislypidemias as risk factor in the countryside. MATERIAL AND METHOD: There have been evaluated 413 patients from the countryside (Jorăşti, Galaţi County), in the period 2008-2010. There was performed history taking, physical examination, an ECG and biological findings (glycemia, colesterolemia, HDL-colesterolemia, trygliceridemia, creatinenemia). RESULTS: In these patients there was noticed a higher prevalence of the dislypidemias in women (65...
October 2010: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Romeo-Gabriel Mihaila, Laurentiu Nedelcu, Ovidiu Fratila, Elena-Cristina Rezi, Carmen Domnariu, Mircea Deac
BACKGROUND/AIMS: Today, there is no ideal treatment for nonalcoholic steatohepatitis. The present study intended to make a multicentric prospective study about the efficiency of lovastatin and pentoxyphyllin administered in patients with nonalcoholic steatohepatitis. METHODOLOGY: 87 patients were included in the present study. The patients diagnosed with nonalcoholic steatohepatitis and dislypidemia were treated for 4 months with lovastatin 10 mg/day and those without dislypidemia with pentoxyphyllin, 400 mg x 3/day...
July 2009: Hepato-gastroenterology
Gema Fernández Fresnedo, Jaime Sánchez Plumed, Manuel Arias, Domingo Del Castillo Caba, María Ovidia López Oliva
Non-immunological factors in the progression of kidney disease in transplant patients are the following: high blood pressure, proteinuria, dislypidemia, etc. 1. Arterial hypertension treatment: Blood pressure must be measured periodically in all transplant patients. Similarly to native kidneys, in renal transplant patients arterial hypertension is a risk factor in the progression of kidney disease. Arterial hypertension represent a clinical marker of chronic allograft nephropathy and contributes to graft loss and to the morbid- mortality of these patients (Evidence level C)...
2009: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
G V Gnoni, G Paglialonga
BACKGROUND: The putative role of resveratrol, a polyphenol present in grapes and other plants, in modulating dislypidemia, thus preventing cardiovascular diseases, is generally based on proliferating cell lines and in vivo studies in different pathological conditions. The aim of the present study was to investigate whether resveratrol plays a role on lipid biosynthesis in rat hepatocytes. MATERIALS AND METHODS: The effect of resveratrol on total rate of fatty acid, cholesterol and complex lipid synthesis, assayed by the incorporation of [1-(14)C]acetate into these lipid fractions, was investigated in rat hepatocyte suspensions...
March 2009: European Journal of Clinical Investigation
Gwenael Kervizic, Laurent Corcos
BACKGROUND: Qualitative dynamics of small gene regulatory networks have been studied in quite some details both with synchronous and asynchronous analysis. However, both methods have their drawbacks: synchronous analysis leads to spurious attractors and asynchronous analysis lacks computational efficiency, which is a problem to simulate large networks. We addressed this question through the analysis of a major biosynthesis pathway. Indeed the cholesterol synthesis pathway plays a pivotal role in dislypidemia and, ultimately, in cancer through intermediates such as mevalonate, farnesyl pyrophosphate and geranyl geranyl pyrophosphate, but no dynamic model of this pathway has been proposed until now...
2008: BMC Systems Biology
Lubia Velázquez-López, María Juana Sil-Acosta, María Victoria Goycochea-Robles, Jorge Escobedo-De la Peña, Rutila Castañeda-Limones
OBJECTIVE: to evaluate a personalized diet customize for present comorbidity, on metabolic control indicators and renal function. METHODS: a non-randomized clinical trial was conducted during a three-month period in a group of patients with microalbuminuria and in a group with macroalbuminuria. The patients received personalized dietary counseling customize to their comorbidity (obesity, hypertension, and dislypidemia). The effect of the diet was measured through metabolic control variables: body mass index (BMI), waist circumference, fasting glucose levels, glycated hemoglobin (HbA(1))c and lipids profile; the renal function variables were: glomerular filtration rate (GFR) and urine albumin excretion (UAE)...
January 2008: Revista Médica del Instituto Mexicano del Seguro Social
A L M de Francisco, J J De la Cruz, A Cases, M de la Figuera, M I Egocheaga, J I Górriz, J I Llisterri, R Marín, A Martínez Castelao
This cross-sectional, multicenter study investigated the prevalence of chronic kidney disease and associated disorders, in an adult population sample (> 18 years old) attending Primary Care services in Spain. Estimated glomerular filtration rate (Modification Diet in Renal Disease equation) was used for analysis of kidney disease prevalence according to NFK-KDOQI (The National Kidney Foundation-Kidney Disease Outcomes Quality Initiative) stages. Data were collected on serum creatinine, other laboratory parameters blood pressure, and medical history of cardiovascular risk factors or disease (hypertension, dislypidemia, diabetes, congestive heart failure, coronary artery disease, stroke or peripheral arteriopathy) in 7,202 patients attending Primary Care Centers...
2007: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Enrique Romero-Velarde, Octavio Campollo-Rivas, Alfredo Celis de la Rosa, Edgar M Vásquez-Garibay, Juan Francisco Castro-Hernández, Rosa M Cruz-Osorio
OBJECTIVE: To assess the risk of dislypidemia associated with obesity in children and adolescents. MATERIAL AND METHODS: A cross sectional study was conducted with 62 obese children (BMI > 95 centile and tricipital skinfold thickness > 90 centile) and 70 non-obese children (BMI 5-85 centile) ages 5-15 years, without chronic diseases. Subjects' characteristics and family background of chronic diseases were collected and a lipid profile was determined. The risk of lipid alterations in the obese children was calculated using odds ratio (OR) and multivariate analysis...
March 2007: Salud Pública de México
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