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studies on thyroid disorders in infertility

https://read.qxmd.com/read/38347677/thyroid-impairment-and-male-fertility-a-narrative-review-of-literature
#1
REVIEW
Valentina Anelli, Elisa Gatta, Ilenia Pirola, Andrea Delbarba, Mario Rotondi, Carlo Cappelli
PURPOSE: To evaluate the effect of thyroid function on male fertility, focusing on hypo- and hyperthyroidism. METHODS: A PubMed/MEDLINE, Web of Science, and Scopus research was performed. Original studies in English published online up to 31 May 2023 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review. RESULTS: The available data in animals (31 studies) and human (26 studies) showed conflicting results...
December 2024: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://read.qxmd.com/read/38078917/endometriosis-polycystic-ovary-syndrome-and-the-thyroid-a-review
#2
REVIEW
Signe Kirkegaard, Nanna Maria Uldall Torp, Stig Andersen, Stine Linding Andersen
Endometriosis and polycystic ovary syndrome (PCOS) are common gynecological disorders that constitute a significant burden of disease in women of fertile age. The disorders share a link to female reproduction and infertility; however, divergent effects on menstrual cycle, related hormones, and body composition have been proposed. Disorders of the thyroid gland including abnormal thyroid dysfunction (hyperthyroidism or hypothyroidism) and/or markers of thyroid autoimmunity similarly show a female predominance and onset in younger age groups...
December 1, 2023: Endocrine Connections
https://read.qxmd.com/read/37986267/the-impact-of-polycystic-ovary-syndrome-pcos-on-the-risk-of-developing-ovarian-cancer-and-thyroid-disorders-a-comprehensive-review
#3
JOURNAL ARTICLE
Payal Mukherjee, Somali Sanyal, Sonia Chadha, Sayali Mukherjee
Polycystic ovary syndrome (PCOS) is a common hormonal disorder that affects women. It is characterized by hyperandrogenism, polycystic ovarian morphology, and other related disorders. It is associated with various health conditions, such as infertility and increased risk of heart problems. Ovarian cancer is also a significant concern, as it is the fifth leading cause of death in women. While there is evidence suggesting a potential association between PCOS and ovarian cancer, the exact nature of this relationship remains unclear...
November 17, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/37702309/endocrine-factors-associated-with-infertility-in-women-an-updated-review
#4
REVIEW
Marcio José Concepción-Zavaleta, Julia Cristina Coronado-Arroyo, Juan Eduardo Quiroz-Aldave, María Del Carmen Durand-Vásquez, Sofía Pilar Ildefonso-Najarro, Luciana Del Pilar Rafael-Robles, Luis Alberto Concepción-Urteaga, Elman Rolando Gamarra-Osorio, Jacsel Suárez-Rojas, José Paz-Ibarra
INTRODUCTION: Infertility is defined as the inability to conceive after unprotected sexual intercourse for at least 12 consecutive months. Our objective is to present an updated narrative review on the endocrine causes of infertility in women. AREAS COVERED: A comprehensive review was conducted using Scielo, Scopus, and EMBASE databases, comprising 245 articles. The pathophysiology of infertility in women was described, including endocrinopathies such as hypothalamic amenorrhea, hyperprolactinemia, polycystic ovary syndrome, primary ovarian insufficiency, obesity, thyroid dysfunction, and adrenal disorders...
2023: Expert Review of Endocrinology & Metabolism
https://read.qxmd.com/read/37679579/assisted-reproductive-technology-and-disease-management-in-infertile-women-with-multiple-sclerosis
#5
REVIEW
Maddalena Sparaco, Luigi Carbone, Doriana Landi, Ylenia Ingrasciotta, Raffaella Di Girolamo, Giacomo Vitturi, Girolama Alessandra Marfia, Carlo Alviggi, Simona Bonavita
Multiple sclerosis (MS) predominantly affects women of fertile age. Various aspects of MS could impact on fertility, such as sexual dysfunction, endocrine alterations, autoimmune imbalances, and disease-modifying therapies (DMTs). The proportion of women with MS (wMS) requesting infertility management and assisted reproductive technology (ART) is increasing over time. In this review, we report on data regarding ART in wMS and address safety issues. We also discuss the clinical aspects to consider when planning a course of treatment for infertility, and provide updated recommendations to guide neurologists in the management of wMS undergoing ART, with the goal of reducing the risk of disease activation after this procedure...
September 7, 2023: CNS Drugs
https://read.qxmd.com/read/37579266/the-impact-of-thyroid-disorders-on-the-clinical-outcome-of-assisted-reproductive-techniques-a-systematic-approach-over-the-last-10-years
#6
REVIEW
Clara Andrade Teixeira, Ana Normélia Pereira de Morais, Gabriel Acácio de Moura, Isadora de Almeida Gomes, Sabrina Vieira de Souza, Mônica Odilha Magalhães Dias, Ana Beatriz Rocha Lima, Paula Bruno Monteiro
OBJECTIVE: To verify from a systematic literature review the possible effects of thyroid diseases on assisted reproduction techniques. DATA SOURCES: The studies were analyzed from the PubMed, Cochrane Library, LILACS databases. SELECTION OF STUDIES: The articles selected for the review included: cross-sectional studies, cohort studies, and clinical trials that addressed the proposed theme and which were published within the period stipulated from January 1, 2012, to March 5, 2022, in English, Portuguese and Spanish...
August 14, 2023: JBRA Assisted Reproduction
https://read.qxmd.com/read/37565097/frequency-of-subclinical-hypothyroidism-among-pregnant-women-a-retrospective-chart-review
#7
JOURNAL ARTICLE
Aliya Islam, Shaharyar K Niazi
Background Subclinical hypothyroidism is a common endocrine disorder during pregnancy, associated with adverse maternal and fetal outcomes. This study aimed to evaluate the frequency of subclinical hypothyroidism among pregnant women who presented to our hospital between 2020 and 2022. Methods A retrospective chart review was conducted on 589 pregnant women using convenience sampling. Only women who underwent thyroid function testing and had no known thyroid disease were included. Data on age, weight status, history of miscarriage, history of infertility, menstrual cycle regularity, thyroid function, and symptoms of thyroid diseases were collected...
July 2023: Curēus
https://read.qxmd.com/read/37476491/protective-effects-of-melatonin-against-oxidative-stress-induced-by-metabolic-disorders-in-the-male-reproductive-system-a-systematic-review-and-meta-analysis-of-rodent-models
#8
Niloofar Dehdari Ebrahimi, Alireza Sadeghi, Moein Ala, Fatemeh Ebrahimi, Sara Pakbaz, Negar Azarpira
BACKGROUND: Male infertility is a multifaceted issue that has gained scientific interest due to its increasing rate. Studies have demonstrated that oxidative stress is involved in male infertility development. Furthermore, metabolic disorders, including obesity, diabetes, hypo- and hyperthyroidism, are risk factors for male infertility, and oxidative stress is believed to contribute to this association. Melatonin, functioning as an oxidative scavenger, may represent a promising therapeutic approach for the prevention and treatment of metabolic disorder-associated male infertility...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37447279/influence-of-vitamin-d-on-the-incidence-of-metabolic-syndrome-and-hormonal-balance-in-patients-with-polycystic-ovary-syndrome
#9
JOURNAL ARTICLE
Katarzyna Lejman-Larysz, Anna Golara, Marta Baranowska, Mateusz Kozłowski, Paweł Guzik, Iwona Szydłowska, Jolanta Nawrocka-Rutkowska, Elżbieta Sowińska-Przepiera, Aneta Cymbaluk-Płoska, Agnieszka Brodowska
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects 8-13% of women of reproductive age. It is one of the most common causes of infertility and is associated with hyperandrogenism in the form of hirsutism and acne, non-ovulatory cycles, and characteristic ovarian morphology. The available research on serum vitamin D deficiency in patients with PCOS and the appropriateness of vitamin D supplementation in this group of women is inconclusive, so we decided to investigate the influence of vitamin D on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome...
June 29, 2023: Nutrients
https://read.qxmd.com/read/37263963/investigation-and-management-of-recurrent-pregnancy-loss-a-comprehensive-review-of-guidelines
#10
REVIEW
Sonia Giouleka, Ioannis Tsakiridis, Elisavet Arsenaki, Ioannis Kalogiannidis, Apostolos Mamopoulos, Evangelos Papanikolaou, Apostolos Athanasiadis, Themistoklis Dagklis
IMPORTANCE: Recurrent pregnancy loss (RPL) is one of the most frustrating clinical entities in reproductive medicine requiring not only diagnostic investigation and therapeutic intervention, but also evaluation of the risk for recurrence. OBJECTIVE: The aim of this study was to review and compare the most recently published major guidelines on investigation and management of RPL. EVIDENCE ACQUISITION: A descriptive review of guidelines from the Royal College of Obstetricians and Gynaecologists, the European Society of Human Reproduction and Embryology, the American Society for Reproductive Medicine, the French College of Gynecologists and Obstetricians, and the German, Austrian, and Swiss Society of Gynecology and Obstetrics on RPL was carried out...
May 2023: Obstetrical & Gynecological Survey
https://read.qxmd.com/read/36695232/a-study-of-hormonal-and-anthropometric-parameters-in-polycystic-ovarian-syndrome
#11
JOURNAL ARTICLE
Tushar Kambale, Komal Devanand Sawaimul, Supriya Prakash
INTRODUCTION: Polycystic Ovarian Syndrome (PCOS) is an endocrinopathy with a complex metabolic disorder. PCOS is characterized by reproductive hormonal imbalances leading to the clinical presentation of hyperandrogenism and infertility. PCOS is also showing an increased prevalence of several other conditions such as obesity, dyslipidemia, hypertension, metabolic syndrome and type 2 diabetes mellitus (DM2) when compared with women without PCOS. The principal symptoms in patients with PCOS are irregular menstruation, acne, and excessive amounts of androgenic hormones...
2023: Annals of African Medicine
https://read.qxmd.com/read/36415442/umbilical-cord-derived-mesenchymal-stem-cells-for-the-treatment-of-infertility-due-to-premature-ovarian-failure
#12
REVIEW
Kritika Garg, Sarju Zilate
Females belonging to the reproductive age group may face challenges regarding infertility or miscarriage due to conditions such as premature ovarian failure (POF). It is the condition that happens when a female's ovaries stop working before she is 40. The majority of the causes of POF cases are idiopathic. Other reasons include genetic disorders (Turner's syndrome, bone morphogenetic protein 15 ( BMP15 ) mutation, galactosemia, mutation of forkhead box protein L2 ( FOXL2 ), growth differentiation factor-9 ( GDF9 ), mutation of luteinizing hormone (LH) and follicle-stimulating hormone receptors ( FSHR ), etc...
October 2022: Curēus
https://read.qxmd.com/read/36219198/efficacy-of-a-proprietary-fenugreek-seed-extract-trigonella-foenum-graecum-furocyst%C3%A2-in-women-with-polycystic-ovary-syndrome-pcos-a-randomized-double-blind-placebo-controlled-study
#13
JOURNAL ARTICLE
Amarjeet Singh, Shalini Gainder, Pradipta Banerjee, Apurva Goel, Pawan Kumar, Banashree Mondal, Samudra P Banik, Debasis Bagchi
INTRODUCTION: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia, a quite common heterogenous endocrine/hormonal disorder, and accompanied by elevated androgen level, menstrual irregularity, and hirsutism. The consequences include infertility or miscarriage. It is a challenging problem to the physicians. In a one-arm, non-randomized preliminary investigation in fifty premenopausal women, we demonstrated the efficacy of Furocyst® , a patented, standardized Trigonella foenum-graecum extract, in ameliorating the symptoms of PCOS over a period of 90 consecutive days...
October 11, 2022: J Am Nutr Assoc
https://read.qxmd.com/read/35971933/the-relationship-between-thyroid-autoimmunity-and-poor-response-to-ovarian-stimulation-in-in-vitro-fertilization-women-with-infertility
#14
JOURNAL ARTICLE
Münire Funda Cevher Akdulum, Mehmet Erdem, Gunel Barut, Erhan Demirdag, Özlem Turhan İyidir, Ismail Guler, Ahmet Erdem
INTRODUCTION: Thyroid autoimmunity (TAI) is the most common autoimmune disorder. Patients with TAI are usually euthyroid, and the presence of anti-thyroid peroxidase (anti-TPO) in patients with or without thyroid dysfunction is associated with infertility, recurrent embryo implantation failure, and early pregnancy loss. We aimed to investigate the relationship between low ovarian reserve, pregnancy outcomes, and TAI. MATERIAL AND METHODS: This retrospective cohort study was conducted in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) patients between 2010 and 2018...
2022: Endokrynologia Polska
https://read.qxmd.com/read/35809279/evaluation-of-basal-hormone-levels-and-androgen-receptor-gene-mutations-in-individuals-with-recurrent-abortion
#15
JOURNAL ARTICLE
Xueqin Huang, Hairong Ju, Guohua Song
A recurrent miscarriage is at least two consecutive miscarriages in the first trimester of pregnancy. Due to the dependence of pregnancy on endocrine changes in the menstrual cycle, its disorders can also affect the outcome of pregnancy. In addition to hormonal disorders, genetic changes are essential factors in recurrent miscarriage. The development and maturation of ovulation depend on the molecular signaling pathways that respond to androgens. Hundreds of mutations leading to resistance to androgen receptor (AR) gene function have been recorded, including the 5'UTR polymorphic region...
January 2, 2022: Cellular and Molecular Biology
https://read.qxmd.com/read/35807751/the-prevalence-and-risk-factors-associated-with-iodine-deficiency-in-canadian-adults
#16
JOURNAL ARTICLE
Stellena Mathiaparanam, Adriana Nori de Macedo, Andrew Mente, Paul Poirier, Scott A Lear, Andreas Wielgosz, Koon K Teo, Salim Yusuf, Philip Britz-Mckibbin
Iodine is a trace micronutrient that is critical for normal thyroid function and human health. Inadequate dietary intake is associated with cognitive impairment, infertility, growth retardation and iodine deficiency disorders in affected populations. Herein, we examined the prevalence of iodine deficiency in adults (median age of 61 years) based on the analysis of 24 h urine samples collected from 800 participants in four clinical sites across Canada in the Prospective Urban and Rural Epidemiological (PURE) study...
June 21, 2022: Nutrients
https://read.qxmd.com/read/35796946/resource-recycling-recovery-and-xenobiotic-remediation-from-e-wastes-through-biofilm-technology-a-review
#17
REVIEW
Sundaram Deepika Bharathi, Aswin Dilshani, Srinivasan Rishivanthi, Pratham Khaitan, Adhinarayan Vamsidhar, Samuel Jacob
Around 50 million tonnes of electronic waste has been generated globally per year, causing an environmental hazard and negative effects on human health, such as infertility and thyroid disorders in adults, endocrine and neurological damage in both animals and humans, and impaired mental and physical development in children. Out of that, only 15% is recycled each year and the remaining is disposed of in a landfill, illegally traded or burned, and treated in a sub-standard way. The processes of recycling are challenged by the presence of brominated flame retardants...
July 7, 2022: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/35433905/chronic-immune-mediated-orchitis-is-the-major-cause-of-acquired-non-obstructive-azoospermia-in-dogs
#18
JOURNAL ARTICLE
Sandra Goericke-Pesch, Larena Reifarth, Christina Behrens Mathiesen, Gerhard Schuler, Anne-Kathrin Umbach, Hanna Körber
Azoospermia, the lack of spermatozoa in the ejaculate, is the most common finding in infertile but otherwise healthy male dogs and represents an increasing reproductive health issue in men, too. The diagnosis can be further classified as non-obstructive azoospermia and obstructive azoospermia due to an obstruction of the deferent ducts. Although non-obstructive azoospermia comprises more than half of azoospermic cases in men and is a common cause of infertility in the male dog, knowledge of the underlying etiology and pathophysiology is still strongly limited, and much uncertainty exists about the true incidence and possible treatment options...
2022: Frontiers in Veterinary Science
https://read.qxmd.com/read/35108218/thyroid-nodules-and-cancer-in-women-with-positive-thyroid-screening-in-pregnancy-a-double-centric-retrospective-study
#19
JOURNAL ARTICLE
Jan Jiskra, Jiří Horáček, Sylvie Špitálníková, Jan Paleček, Zdeňka Límanová, Jan Krátký, Drahomíra Springer, Kristýna Žabková, Hana Vítková
OBJECTIVE: Thyroid nodules are a common finding in the general population. The primary aim of the study was to determine the prevalence of thyroid nodules and cancer found by ultrasound in women who underwent screening for thyroid dysfunction during pregnancy. DESIGN: A double-centric, retrospective, cohort study. PATIENTS AND METHODS: We searched through medical records, including thyroid ultrasonography, of pregnant women positively screened for thyroid disorders (using TSH and thyroid antibodies) from unselected population ("universal screening group", N=690), and of women who underwent the testing based on the presence of clinical risk factors defined by American Thyroid Association ("case-finding group", N=249)...
February 1, 2022: European Thyroid Journal
https://read.qxmd.com/read/34598733/the-relationship-between-thyroid-function-and-ovarian-reserve-a-prospective-cross-sectional-study
#20
JOURNAL ARTICLE
Roya Kabodmehri, Seyedeh Hajar Sharami, Ziba Zahiri Sorouri, Nasrin Ghanami Gashti, Forozan Milani, Zeinab Chaypaz, Maryam Ghalandari
BACKGROUND: Thyroid dysfunction can affect fertility and miscarriage risk by affecting the process of follicular growth, embryo development, implantation, and placental formation. It has been suggested that thyroid disorders are associated with ovarian reserve by affecting the follicular process. The aim of the present study was to investigate the relationship between thyroid hormone levels and ovarian reserve. METHODS: Three hundred fourteen women with infertility due to various etiologies were enrolled in this study (172 individuals with Anti-Mullerian hormone (AMH) level ≥ 1...
October 1, 2021: Thyroid Research
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