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https://www.readbyqxmd.com/read/29178936/diallyl-disulphide-inhibits-apolipoprotein-a-expression-in-hepg2-cells-through-the-mek1-erk1-2-elk-1-pathway
#1
Xiaofeng Ma, Yami Liu, Yanmei Tan, Kai Qu, Xinglan He, Hai Zhang, Zuo Wang
BACKGROUND: Lipoprotein(a) [LP(a)] is implicated as a common and independent risk factor for cardiovascular diseases. The therapeutic options currently available for reducing plasma LP(a) concentrations are limited. Diallyl disulphide (DADS), the main component of garlic, regulates lipid metabolism in hepatocytes and adipocytes through ERK1/2 signalling. This study aimed to assess the effect of DADS on apolipoprotein(a) [apo(a)] in HepG2 cells. We also determined the effects of DADS on apo(a) expression and secretion in HepG2 cells as well as the underlying mechanisms...
November 25, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29158710/the-impact-of-pharmacists-providing-direct-patient-care-as-members-of-interprofessional-teams-on-diabetes-management
#2
Osamah M Alfayez, Majed S Al Yami, Maryam T Fazel
The purpose of this study was to evaluate the impact of pharmacist providing direct patient care as a member of interprofessional team on diabetes management. This study is a retrospective chart review of diabetes patients seen by a pharmacist in an endocrinology clinic affiliated with an academic medical center. The following patient outcomes were recorded pre and post the pharmacist intervention: glycemic control as measured by change in hemoglobin A1c (HbA1c), change in systolic blood pressure (SBP) and diastolic blood pressure (DBP), statin use, and use of angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs)...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29125326/young-schema-questionnaire%C3%A2-%C3%A2-short-form-version-3-ysq-s3-preliminary-validation-in-older-adults
#3
Katelyn Phillips, Robert Brockman, Phoebe E Bailey, Ian I Kneebone
OBJECTIVES: The aim of the current study was to establish the reliability and validity of one of the most used schema questionnaires, Young Schema Questionnaire Short Form Version 3 (YSQ-S3) in older adults. METHOD: 104 participants aged 60-84 years were recruited. They were administered a battery of questionnaires, including the YSQ-S3, Young-Atkinson Mode Inventory (YAMI), Germans (Personality) Screener, the Geriatric Depression Scale (GDS), The Geriatric Anxiety Inventory (GAI) and the Basic Psychological Needs Scale (BPNS)...
November 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29043538/venous-thromboembolism-prophylaxis-in-medically-ill-patients-a-mixed-treatment-comparison-meta-analysis
#4
REVIEW
Majed S Al Yami, Matthew A Silva, Jennifer L Donovan, Abir O Kanaan
The American College of Chest Physicians guidelines recommend unfractionated heparin (UFH), low molecular weight heparins (LMWHs) or fondaparinux for prevention of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), in medically-ill patients. Direct oral anticoagulants (DOACs) have been evaluated relative to enoxaparin for VTE prophylaxis though head-to-head comparisons of these agents are lacking. Therefore, we conducted a mixed treatment comparisons meta-analysis to evaluate the safety and efficacy of established treatments and DOACs for VTE prophylaxis in medically-ill patients...
October 17, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28550979/status-of-blood-transfusion-in-world-health-organization-eastern-mediterranean-region-who-emr-successes-and-challenges
#5
REVIEW
Arezoo Darbandi, Pargol Mashati, Amir Yami, Arshia Gharehbaghian, Mehdi Tabrizi Namini, Ahmad Gharehbaghian
BACKGROUND: Blood products are used for patient treatment and survival in the cases of major surgery, hematological disorders or cancer therapy. Presently the main blood components are not yet replaceable by artificial products and all activities related to blood transfusion is highly dependent on the healthcare development of each country. The World Health Organization Eastern Mediterranean Region (WHO-EMR) comprises of 21 member states with variable socio-economic status effective on blood transfusion activities...
May 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28343141/survival-outcomes-in-iron-chelated-and-non-chelated-patients-with-lower-risk-myelodysplastic-syndromes-review-and-pooled-analysis-of-observational-studies
#6
EDITORIAL
Ivo Abraham, Majed Al Yami, Seongseok Yun, Hee-Ju Kim, Nicole D Vincelette, Ali McBride, Karen MacDonald
No abstract text is available yet for this article.
March 18, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28209320/comparison-of-the-incidence-of-acute-kidney-injury-during-treatment-with-vancomycin-in-combination-with-piperacillin-tazobactam-or-with-meropenem
#7
Majed S Al Yami
The purpose of this study was to evaluate the observed incidence of acute kidney injury (AKI) in adult patients receiving either piperacillin-tazobactam (PT) and vancomycin or meropenem and vancomycin for at least 48h. In this retrospective cohort study, we included adult patients with no known renal dysfunction who received either the combination of PT-vancomycin or meropenem-vancomycin for at least 48h. The study's primary outcome was the incidence of acute kidney injury (AKI), defined by the Kidney Disease: Improving Global Outcomes (KDIGO) in patients with baseline normal renal function as an increase in serum creatinine (Scr) by ≥0...
November 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28197755/direct-oral-anticoagulants-for-extended-duration-thromboprophylaxis-in-hospitalized-medically-ill-patients-are-we-there-yet
#8
Majed S Al Yami, Osamah M Alfayez, Sawsan M Kurdi, Razan Alsheikh
Despite a recommended 7-10 days of thromboprophylaxis, medically ill patients remain at increased risk of developing venous thromboembolism (VTE) after hospital discharge. Here, we present a contemporary review on the efficacy and safety of extended-duration thromboprophylaxis with direct oral anticoagulants (DOACs) in hospitalized medically ill patients. A search of publication and trial databases of controlled trials conducted from 2010 to 2016 using the key terms apixaban, rivaroxaban, and betrixaban showed three phase III trials that met our search criteria...
July 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27975190/investigation-of-marek-s-disease-virus-from-chickens-in-central-ethiopia
#9
Berhan Demeke, Shiferaw Jenberie, Biruk Tesfaye, Gelagay Ayelet, Martha Yami, Charles Euloge Lamien, Esayas Gelaye
Marek's disease (MD) is a lymphoproliferative and neuropathic disease of domestic chickens and less commonly, turkeys and quails, caused by a highly contagious, cell-associated, oncogenic herpesvirus. In Ethiopia, MD is believed to be introduced with importation of exotic and crossbred to improve the poultry production and has been reported to be a potential threat to the poultry sector both in backyard and commercial farming systems. This study was aimed at isolation and molecular analysis of MD virus isolates circulating in chicken population in the central part of Ethiopia where commercial farms are populated...
February 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27960065/toward-a-better-compression-for-dna-sequences-using-huffman-encoding
#10
Anas Al-Okaily, Badar Almarri, Sultan Al Yami, Chun-Hsi Huang
Due to the significant amount of DNA data that are being generated by next-generation sequencing machines for genomes of lengths ranging from megabases to gigabases, there is an increasing need to compress such data to a less space and a faster transmission. Different implementations of Huffman encoding incorporating the characteristics of DNA sequences prove to better compress DNA data. These implementations center on the concepts of selecting frequent repeats so as to force a skewed Huffman tree, as well as the construction of multiple Huffman trees when encoding...
April 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/27931235/erratum-to-serological-response-and-protection-level-evaluation-in-chickens-exposed-to-grains-coated-with-i2-newcastle-disease-virus-for-effective-oral-vaccination-of-village-chickens
#11
Reta D Abdi, Kassaw Amssalu Tadesse, Olana Merera, Yilkal Asfaw, Eseyas Gelaye, Marta Yami, Teshale Sori
No abstract text is available yet for this article.
December 8, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27544702/genetic-characterization-of-poxviruses-in-camelus-dromedarius-in-ethiopia-2011-2014
#12
Esayas Gelaye, Jenna Elizabeth Achenbach, Gelagay Ayelet, Shiferaw Jenberie, Martha Yami, Reingard Grabherr, Angelika Loitsch, Adama Diallo, Charles Euloge Lamien
Camelpox and camel contagious ecthyma are infectious viral diseases of camelids caused by camelpox virus (CMLV) and camel contagious ecthyma virus (CCEV), respectively. Even though, in Ethiopia, pox disease has been creating significant economic losses in camel production, little is known on the responsible pathogens and their genetic diversity. Thus, the present study aimed at isolation, identification and genetic characterization of the causative viruses. Accordingly, clinical case observations, infectious virus isolation, and molecular and phylogenetic analysis of poxviruses infecting camels in three regions and six districts in the country, Afar (Chifra), Oromia (Arero, Miyu and Yabello) and Somali (Gursum and Jijiga) between 2011 and 2014 were undertaken...
October 2016: Antiviral Research
https://www.readbyqxmd.com/read/27457794/serological-response-and-protection-level-evaluation-in-chickens-exposed-to-grains-coated-with-i2-newcastle-disease-virus-for-effective-oral-vaccination-of-village-chickens
#13
RANDOMIZED CONTROLLED TRIAL
Reta D Abdi, Kasahun Amsalu, Olana Merera, Yilkal Asfaw, Eseyas Gelaye, Marta Yami, Teshale Sori
BACKGROUND: Conventional Newcastle disease (ND) vaccination strategies in village chicken production settings is impractical due to shortage of cold-chain, unsuitability of vaccine administration routes and demanding trained personnel and hence affected its adoption. Results from earlier works elsewhere showed that the heat stable vaccines such as NDI2 are thought to be promising for village chickens. This study investigated the suitability and efficacy of Ethiopian cereal grains as carriers for the orally administrated NDI2 vaccine in chickens...
July 25, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27386230/assessment-of-selected-nutrients-and-toxic-metals-in-fruits-soils-and-irrigation-waters-of-awara-melka-and-nura-era-farms-ethiopia
#14
Shambel G Yami, Bhagwan Singh Chandravanshi, Taddese Wondimu, Cherinet Abuye
The objective of the present study was to determine the levels of essential nutrients (Na, K, Ca, Mg, Fe, Cu, Zn, Mn) and toxic metals (Pb and Cd) in selected varieties of fruits (banana, grape, guava, mandarin and orange), farmland soils and irrigation waters to assess nutritional impact on health. The freeze dried fruits were digested using HNO3 and HClO4 and the levels of the elements determined using flame atomic absorption spectrometer. The highest amount of K (3480) and Mg (281) and the lowest amount of Na (6...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27211823/identification-of-a-new-genotype-of-african-swine-fever-virus-in-domestic-pigs-from-ethiopia
#15
J E Achenbach, C Gallardo, E Nieto-Pelegrín, B Rivera-Arroyo, T Degefa-Negi, M Arias, S Jenberie, D D Mulisa, D Gizaw, E Gelaye, T R Chibssa, A Belaye, A Loitsch, M Forsa, M Yami, A Diallo, A Soler, C E Lamien, J M Sánchez-Vizcaíno
African swine fever (ASF) is an important emerging transboundary animal disease (TAD), which currently has an impact on many countries in Africa, Eastern Europe, the Caucasus and the Russian Federation. The current situation in Europe shows the ability of the virus to rapidly spread, which stands to threaten the global swine industry. At present, there is no viable vaccine to minimize spread of the disease and stamping out is the main source of control. In February 2011, Ethiopia had reported its first suspected outbreaks of ASF...
May 22, 2016: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/26923232/molecular-characterization-of-orf-virus-from-sheep-and-goats-in-ethiopia-2008-2013
#16
Esayas Gelaye, Jenna Elizabeth Achenbach, Shiferaw Jenberie, Gelagay Ayelet, Alebachew Belay, Martha Yami, Angelika Loitsch, Reingard Grabherr, Adama Diallo, Charles Euloge Lamien
BACKGROUND: Orf is a contagious disease of sheep, goats and wild ungulates caused by orf virus (ORFV) a member of the genus Parapoxvirus, Poxviridae family. Although orf is endemic in Ethiopia, little attention has been given so far as it is not a notifiable disease by the World Organization for Animal Health. In this work, we have investigated orf outbreaks representing five different geographical locations of Ethiopia, in Amba Giorgis, Gondar zuria, Adet, Debre zeit and Adami Tulu, between 2008 and 2013...
February 29, 2016: Virology Journal
https://www.readbyqxmd.com/read/26814267/diversion-and-illicit-sale-of-extended-release-tapentadol-in-the-united-states
#17
Richard C Dart, Hilary L Surratt, Marie-Claire Le Lait, Yami Stivers, Vikhyat S Bebarta, Clark C Freifeld, John S Brownstein, John J Burke, Steven P Kurtz, Nabarun Dasgupta
OBJECTIVE:   Prescription opioid analgesics are commonly prescribed for moderate to severe pain. An unintended consequence of prescribing opioid analgesics is the abuse and diversion of these medications. Tapentadol ER is a recently approved centrally acting analgesic with synergistic mechanisms of action: μ-opioid receptor agonism and inhibition of norepinephrine reuptake. We assessed the amount of diversion and related cost of obtaining tapentadol IR (Nucynta®) and tapentadol ER (Nucynta ER®) as well as other Schedule II opioid medications in street transactions in the United States using the Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS®) System...
August 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/26715196/transfusion-and-treatment-of-severe-anaemia-in-african-children-tract-a-study-protocol-for-a-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Ayub Mpoya, Sarah Kiguli, Peter Olupot-Olupot, Robert O Opoka, Charles Engoru, Macpherson Mallewa, Yami Chimalizeni, Neil Kennedy, Dorothy Kyeyune, Benjamin Wabwire, Bridon M'baya, Imelda Bates, Britta Urban, Michael Boele von Hensbroek, Robert Heyderman, Margaret J Thomason, Sophie Uyoga, Thomas N Williams, Diana M Gibb, Elizabeth C George, A Sarah Walker, Kathryn Maitland
BACKGROUND: In sub-Saharan Africa, where infectious diseases and nutritional deficiencies are common, severe anaemia is a common cause of paediatric hospital admission, yet the evidence to support current treatment recommendations is limited. To avert overuse of blood products, the World Health Organisation advocates a conservative transfusion policy and recommends iron, folate and anti-helminthics at discharge. Outcomes are unsatisfactory with high rates of in-hospital mortality (9-10%), 6-month mortality and relapse (6%)...
December 29, 2015: Trials
https://www.readbyqxmd.com/read/25907637/capripox-disease-in-ethiopia-genetic-differences-between-field-isolates-and-vaccine-strain-and-implications-for-vaccination-failure
#19
Esayas Gelaye, Alebachew Belay, Gelagay Ayelet, Shiferaw Jenberie, Martha Yami, Angelika Loitsch, Eeva Tuppurainen, Reingard Grabherr, Adama Diallo, Charles Euloge Lamien
Sheeppox virus (SPPV), goatpox virus (GTPV) and lumpy skin disease virus (LSDV) of the genus Capripoxvirus (CaPV) cause capripox disease in sheep, goats and cattle, respectively. These viruses are not strictly host-specific and their geographical distribution is complex. In Ethiopia, where sheep, goats and cattle are all affected, a live attenuated vaccine strain (KS1-O180) is used for immunization of both small ruminants and cattle. Although occurrences of the disease in vaccinated cattle are frequently reported, information on the circulating isolates and their relation to the vaccine strain in use are still missing...
July 2015: Antiviral Research
https://www.readbyqxmd.com/read/25157693/voluntary-action-and-neural-causation
#20
COMMENT
Hanoch Ben-Yami
I agree with Nachev and Hacker's general approach. However, their criticism of claims of covert automaticity can be strengthened. I first say a few words on what voluntary action involves and on the consequent limited relevance of brain research for the determination of voluntariness. I then turn to Nachev and Hacker's discussion of possible covert automaticity and show why the case for it is weaker than they allow.
2014: Cognitive Neuroscience
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