keyword
https://read.qxmd.com/read/38061895/comparing-the-pathology-clinical-and-demographic-characteristics-of-younger-and-older-onset-multiple-sclerosis
#21
JOURNAL ARTICLE
Sarah Knowles, Rod Middleton, Benjamin Cooze, Ildiko Farkas, Yeung Yeung Leung, Kelsey Allen, Molly Winslade, David R J Owen, Roberta Magliozzi, Richard Reynolds, James W Neal, Owen Pearson, Richard Nicholas, W Owen Pickrell, Owain W Howell
OBJECTIVE: Older people with multiple sclerosis (MS) have a less active radiological and clinical presentation, but many still attain significant levels of disability; but what drives worsening disability in this group? METHODS: We used data from the UK MS Register to characterize demographics and clinical features of late-onset multiple sclerosis (LOMS; symptom onset at ≥50 years), compared with adult-onset MS (AOMS; onset 18-49 years). We performed a pathology study of a separate MS cohort with a later onset (n = 18, mean age of onset 54 years) versus AOMS (n = 23, mean age of onset 29 years)...
December 7, 2023: Annals of Neurology
https://read.qxmd.com/read/38030026/anti-inflammatory-effect-and-mechanism-of-active-parts-of-artemisia-mongolica-in-lps-induced-raw264-7%C3%A2-cells-based-on-network-pharmacology-analysis
#22
JOURNAL ARTICLE
Fangsheng Wang, Liu Liu, ZiWei Zhu, Haji Akber Aisa, Xuelei Xin
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia mongolica is well known for its use in folk medicine, it is commonly used to alleviate a variety of diseases associated with inflammation, such as laryngitis, tonsillitis, headaches and hepatitis in northwest China. However, its anti-inflammatory mechanism is still unknown. AIM OF THE STUDY: The most potential anti-inflammatory part (AMPA) was identified by screening individual parts of A. Mongolica. After the network pharmacological analysis, the anti-inflammation effects and molecular mechanisms of AMPA were evaluated in RAW264...
November 27, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37981082/frequency-and-functional-characterization-of-fusion-genes-in-squamous-cell-carcinoma-of-the-lung
#23
JOURNAL ARTICLE
Christina Alidousty, Arvid Becker, Elke Binot, Axel M Hillmer, Sabine Merkelbach-Bruse, Birgit Budde, Ingelore Bäßmann, Gunter Rappl, Jürgen Wolf, Marie-Lisa Eich, Ka-Won Noh, Reinhard Buettner, Anne Maria Schultheis
INTRODUCTION: In contrast to lung adenocarcinoma (LUAD), targetable genetic alterations are less frequently detected in squamous cell carcinoma of the lung (LUSC). Over the last years, gene fusions have become promising targets in many solid cancers. Here, we analysed a cohort of LUSC, identified recurrent fusion genes and functionally characterised these tumour genomes. METHODS: A subset of 1608 squamous cell carcinomas of the lung was analysed by means of the FusionPlex® Lung Panel to identify potentially targetable gene fusions using targeted next-generation sequencing...
February 15, 2024: Gene
https://read.qxmd.com/read/37970606/the-quest-for-the-optimal-biomarker-is-extending-the-spectrum-of-targeted-pik3ca-mutations-in-breast-cancer-carcinoma-worthwhile
#24
EDITORIAL
Stanislas Quesada, William Jacot
No abstract text is available yet for this article.
October 25, 2023: Annals of Translational Medicine
https://read.qxmd.com/read/37950996/mycoplasma-pneumoniae-carriage-in-children-with-recurrent-respiratory-tract-infections-is-associated-with-a-less-diverse-and-altered-microbiota
#25
JOURNAL ARTICLE
Mischa H Koenen, Ruben C A de Groot, Wouter A A de Steenhuijsen Piters, Mei Ling J N Chu, Kayleigh Arp, Raïza Hasrat, Ad C J M de Bruijn, Silvia C Estevão, Erhard van der Vries, Jeroen D Langereis, Marianne Boes, Debby Bogaert, Annemarie M C van Rossum, Wendy W J Unger, Lilly M Verhagen
BACKGROUND: Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in school-aged children and can be preceded by asymptomatic carriage. However, its role in recurrent respiratory tract infections is unclear. We studied the prevalence of M.pneumoniae carriage in children with recurrent respiratory infections and identified associated factors. METHODS: We tested M.pneumoniae carriage by qPCR in children with recurrent infections and their healthy family members in a cross-sectional study...
December 2023: EBioMedicine
https://read.qxmd.com/read/37926337/application-of-a-deep-learning-system-to-detect-papilledema-on-nonmydriatic-ocular-fundus-photographs-in-an-emergency-department
#26
JOURNAL ARTICLE
Valérie Biousse, Raymond P Najjar, Zhiqun Tang, Mung Yan Lin, David W Wright, Matthew T Keadey, Tien Y Wong, Beau B Bruce, Dan Milea, Nancy J Newman
PURPOSE: The Fundus photography vs. Ophthalmoscopy Trial Outcomes in the Emergency Department (FOTO-ED) studies showed that ED providers poorly recognized funduscopic findings in ED patients. We tested a modified version of the Brain and Optic Nerve Study Artificial Intelligence (BONSAI) deep learning system on nonmydriatic fundus photographs from the FOTO-ED studies to determine if the DLS could have improved the detection of papilledema had it been available to ED providers as a real-time diagnostic aid...
November 4, 2023: American Journal of Ophthalmology
https://read.qxmd.com/read/37892129/usefulness-of-proguanylin-pentraxin-3-and-s100a12-serum-concentrations-in-diagnosis-and-monitoring-the-disease-activity-in-crohn-s-disease
#27
JOURNAL ARTICLE
Aleksandra Kałużna, Agnieszka Jura-Półtorak, Alicja Derkacz, Krystyna Olczyk, Katarzyna Komosinska-Vassev
The aim of our case-control study was to identify novel biomarkers of Crohn's disease (CD) that hold the potential to be employed in both disease diagnosis and monitoring activity. In the context of the contribution of intestinal barrier integrity and immune response to the pathogenesis of CD, we assessed the serum concentrations of proguanylin (pro-GN), pentraxin 3 (PTX3) and S100A12 in 20 patients before and after anti-inflammatory treatment, as well as in 20 healthy individuals. Statistical analyses revealed a significant difference in the levels of pro-GN (5...
September 26, 2023: Biomolecules
https://read.qxmd.com/read/37879391/health-and-economic-burden-of-wildland-fires-pm-2-5-related-pollution-in-portugal-a-longitudinal-study
#28
JOURNAL ARTICLE
Joana V Barbosa, Rafael A O Nunes, Maria C M Alvim-Ferraz, Fernando G Martins, Sofia I V Sousa
Portugal has been affected by wildland fires that destroy thousands of hectares of forest, causing damage to the environment and to the exposed populations. This study aims to assess the influence of wildland fire emissions on air quality, its effect on population health and the related costs, between 2015 and 2018 in Portugal. The cause-specific mortality due to PM2.5 was calculated considering the exposure for five endpoints in adults, twelve age groups for adults and considering children under five years old...
October 23, 2023: Environmental Research
https://read.qxmd.com/read/37869466/a-high-performance-computing-technology-powered-multimedia-fusion-model-in-university-english-translation
#29
JOURNAL ARTICLE
Lin Shi, Minne DuJiang, Ping Gao
Various forms of materials, such as pictures, videos and texts, have rapidly brought the college English translation teaching model into the era of multimedia integration. This makes it difficult for English teachers to improve college English translation by using unique materials, so as to form their own unique teaching style. In view of this, a multimedia comprehensive English translation framework based on the combination of big data technology and multimedia teaching mode is proposed. At the same time, the idea of building the framework is introduced from two perspectives: the integration of big data technology and multimedia, and the integration of multimedia and English teaching process...
2023: PeerJ. Computer Science
https://read.qxmd.com/read/37822843/postpandemic-fear-of-covid-19-psychological-distress-and-resilient-coping-among-frontline-health-workers-in-ghana-an-analytical-cross-sectional-study
#30
JOURNAL ARTICLE
Evelyn Adu Fofie, Emmanuel Ekpor, Samuel Akyirem
BACKGROUND AND AIMS: The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted the psychological well-being of healthcare workers globally. However, little is known about the mental health state of frontline health workers in the postpandemic era. The purpose of this study was to examine postpandemic COVID-19-related psychological distress and fear among frontline health workers in Ghana. METHODS: Data were collected from 245 frontline healthcare workers in the Western region of Ghana...
October 2023: Health Science Reports
https://read.qxmd.com/read/37785418/ct-vs-mri-which-is-more-accurate-in-grading-rectal-wall-infiltration-after-hydrogel-spacer-placement-for-prostate-cancer-patients
#31
JOURNAL ARTICLE
P Shamsesfandabadi, S Ponnapalli, K Spencer, A Patel, Y Yin, S Abel, S Beriwal, R E Wegner, A K Patel, Z D Horne
PURPOSE/OBJECTIVE(S): The purpose of this study was to evaluate the incidence and severity of rectal wall infiltration (RWI) in prostate cancer patients after rectal hydrogel spacer implantation, a commonly used procedure to minimize rectal radiation exposure during prostate radiotherapy. The study aimed to determine correlation of RWI using computed tomography (CT) scans and magnetic resonance imaging (MRI) scans in order to determine the optimal post-placement imaging modality. MATERIALS/METHODS: This retrospective study was conducted on 370 patients diagnosed with localized prostate cancer who underwent rectal hydrogel spacer placement from 2020 to 2022...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37750530/treatment-effect-of-implant-supported-fixed-complete-dentures-and-implant-overdentures-on-patient-reported-outcomes-a-systematic-review-and-meta-analysis
#32
REVIEW
Samir Abou-Ayash, Manrique Fonseca, Stefano Pieralli, Daniel R Reissmann
OBJECTIVES: To analyze the effect of implant treatment in edentulous patients rehabilitated with implant-supported fixed complete dentures (IFCDs) or implant overdentures (IODs) on dental patient-reported outcomes (dPROs). MATERIALS AND METHODS: In January 2022, Medline, Embase, CINAHL, Cochrane Library, PubMed Central, Web of Science, and ClinicalTrials.gov were screened for prospective clinical studies on completely edentulous patients treated with IFCDs and/or IODs, reporting pre-treatment and follow-up dPROs...
September 2023: Clinical Oral Implants Research
https://read.qxmd.com/read/37713965/risk-of-wound-infection-with-use-of-sterile-versus-clean-gloves-in-wound-repair-at-the-emergency-department-a-systematic-review-and-meta-analysis
#33
REVIEW
Yong Yi Tan, Zhuo Xun Chua, Guan Hin Loo, Jamie Si Pin Ong, Jia Hao Lim, Fahad Javaid Siddiqui, Nicholas Graves, Andrew Fu Wah Ho
STUDY OBJECTIVE: Sterile gloves are widely used during wound repair procedures in Emergency Departments (ED) worldwide. It is unclear whether sterile gloves protect against postoperative wound infections. We conducted a systematic review and meta-analysis to determine if sterile gloves offer significant protection against wound infections compared to clean gloves for wound repair in the ED. METHODS: Ovid MEDLINE, Ovid Embase, Cochrane Library and Web Of Science were searched for randomised controlled trials (RCTs) or non-randomized studies of intervention (NRSIs) from their dates of inception to January 2023...
November 2023: Injury
https://read.qxmd.com/read/37704375/lee-et-al-neural-evidence-for-boundary-updating-as-the-source-of-the-repulsive-bias-in-classification
#34
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
September 13, 2023: Journal of Neuroscience
https://read.qxmd.com/read/37696862/modeling-of-soil-moisture-movement-and-wetting-behavior-under-point-source-trickle-irrigation
#35
JOURNAL ARTICLE
Dinesh Kumar Vishwakarma, Rohitashw Kumar, Salwan Ali Abed, Nadhir Al-Ansari, Amit Kumar, Nand Lal Kushwaha, Devideen Yadav, Anita Kumawat, Alban Kuriqi, Abed Alataway, Ahmed Z Dewidar, Mohamed A Mattar
The design and selection of ideal emitter discharge rates can be aided by accurate information regarding the wetted soil pattern under surface drip irrigation. The current field investigation was conducted in an apple orchard in SKUAST- Kashmir, Jammu and Kashmir, a Union Territory of India, during 2017-2019. The objective of the experiment was to examine the movement of moisture over time and assess the extent of wetting in both horizontal and vertical directions under point source drip irrigation with discharge rates of 2, 4, and 8 L h-1 ...
September 11, 2023: Scientific Reports
https://read.qxmd.com/read/37659643/early-life-pm-2-5-exposure-childhood-cognitive-ability-and-mortality-between-age-11-and-86-a-record-linkage-life-course-study-from-scotland
#36
JOURNAL ARTICLE
Gergő Baranyi, Lee Williamson, Zhiqiang Feng, Sam Tomlinson, Massimo Vieno, Chris Dibben
BACKGROUND: Living in areas with high air pollution concentrations is associated with all-cause and cause-specific mortality. Exposure in sensitive developmental periods might be long-lasting but studies with very long follow-up are rare, and mediating pathways between early life exposure and life-course mortality are not fully understood. METHODS: Data were drawn from the Scottish Longitudinal Study Birth Cohort of 1936, a representative record-linkage study comprising 5% of the Scottish population born in 1936...
August 31, 2023: Environmental Research
https://read.qxmd.com/read/37647001/lectin-affinity-chromatography
#37
JOURNAL ARTICLE
Brendan F O'Connor, Donal Monaghan, Jonathan Cawley
Glycosylation is a non-template-driven posttranslational modification during which linked-sugars and glycans are added to the nascent polypeptide. Over 70% of the eukaryotic proteome is thought to be glycosylated. It is now known that correct glycosylation is essential for the correct folding, solubility, stability, and immunogenicity of proteins. In this chapter, we describe the technique of lectin affinity chromatography (LAC), a procedure that has the ability to distinguish different glycans, which are attached to proteins or lipids, termed glycoproteins or glycolipids, respectively...
2023: Methods in Molecular Biology
https://read.qxmd.com/read/37640035/effect-of-colchicine-on-perioperative-atrial-fibrillation-and-myocardial-injury-after-non-cardiac-surgery-in-patients-undergoing-major-thoracic-surgery-cop-af-an-international-randomised-trial
#38
JOURNAL ARTICLE
David Conen, Michael Ke Wang, Ekaterine Popova, Matthew T V Chan, Giovanni Landoni, Juan P Cata, Cara Reimer, Sean R McLean, Sadeesh K Srinathan, Juan Carlos Trujillo Reyes, Ascension Martín Grande, Anna Gonzalez Tallada, Daniel I Sessler, Edith Fleischmann, Barbara Kabon, Luca Voltolini, Patrícia Cruz, Donna E Maziak, Laura Gutiérrez-Soriano, William F McIntyre, Vikas Tandon, Elisabeth Martínez-Téllez, Juan Jose Guerra-Londono, Deborah DuMerton, Randolph H L Wong, Anna L McGuire, Biniam Kidane, Diego Parise Roux, Yaron Shargall, Jennifer R Wells, Sandra N Ofori, Jessica Vincent, Lizhen Xu, Zhuoru Li, John W Eikelboom, Sanjit S Jolly, Jeff S Healey, P J Devereaux
BACKGROUND: Higher levels of inflammatory biomarkers are associated with an increased risk of perioperative atrial fibrillation and myocardial injury after non-cardiac surgery (MINS). Colchicine is an anti-inflammatory drug that might reduce the incidence of these complications. METHODS: COP-AF was a randomised trial conducted at 45 sites in 11 countries. Patients aged 55 years or older and undergoing major non-cardiac thoracic surgery were randomly assigned (1:1) to receive oral colchicine 0·5 mg twice daily or matching placebo, starting within 4 h before surgery and continuing for 10 days...
August 25, 2023: Lancet
https://read.qxmd.com/read/37636901/cost-effectiveness-of-single-inhaler-triple-therapy-ff-umec-vi-versus-tiotropium-monotherapy-in-patients-with-symptomatic-moderate-to-very-severe-copd-in-the-uk
#39
JOURNAL ARTICLE
Robyn Kendall, Alan A Martin, Dhvani Shah, Soham Shukla, Chris Compton, Afisi S Ismaila
PURPOSE: For patients with chronic obstructive pulmonary disease (COPD) who remain symptomatic despite maintenance treatment, clinical management guidelines recommend a stepwise escalation from monotherapy to dual therapy, and from dual therapy to triple therapy. However, in clinical practice, patients are often escalated directly from monotherapy to triple therapy based on disease severity. This study evaluated the cost-effectiveness of once-daily, single-inhaler fluticasone furoate, umeclidinium, and vilanterol (FF/UMEC/VI) triple therapy compared with long-acting muscarinic antagonist monotherapy with once-daily tiotropium (TIO) in patients with symptomatic moderate-to-very severe COPD, from a UK National Health Service perspective...
2023: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/37569533/transcriptomic-and-functional-analyses-of-two-cadmium-hyper-enriched-duckweed-strains-reveal-putative-cadmium-tolerance-mechanisms
#40
JOURNAL ARTICLE
Gui-Li Yang, Lei Huang, Xiao Yang, Zhu Li, Hai-Min Liao, Kang Mao, Zhao-Ju Liu, He-Yan Geng, Qin Cao, Ai-Juan Tan
Cadmium (Cd) is one of the most toxic metals in the environment and exerts deleterious effects on plant growth and production. Duckweed has been reported as a promising candidate for Cd phytoremediation. In this study, the growth, Cd enrichment, and antioxidant enzyme activity of duckweed were investigated. We found that both high-Cd-tolerance duckweed (HCD) and low-Cd-tolerance duckweed (LCD) strains exposed to Cd were hyper-enriched with Cd. To further explore the underlying molecular mechanisms, a genome-wide transcriptome analysis was performed...
July 29, 2023: International Journal of Molecular Sciences
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