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https://www.readbyqxmd.com/read/28665235/facial-feature-tracking-a-psychophysiological-measure-to-assess-exercise-intensity
#1
Kathleen H Miles, Bradley Clark, Julien D Périard, Roland Goecke, Kevin G Thompson
The primary aim of this study was to determine whether facial feature tracking reliably measures changes in facial movement across varying exercise intensities. Fifteen cyclists completed three, incremental intensity, cycling trials to exhaustion while their faces were recorded with video cameras. Facial feature tracking was found to be a moderately reliable measure of facial movement during incremental intensity cycling (intra-class correlation coefficient = 0.65-0.68). Facial movement (whole face (WF), upper face (UF), lower face (LF) and head movement (HM)) increased with exercise intensity, from lactate threshold one (LT1) until attainment of maximal aerobic power (MAP) (WF 3464 ± 3364mm, P < 0...
June 30, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28653802/safety-profile-of-h1-antihistamines-in-pediatrics-an-analysis-based-on-data-from-vigibase
#2
Domenico Motola, Monia Donati, Chiara Biagi, Elisabetta Calamelli, Francesca Cipriani, Mauro Melis, Luca Monaco, Alberto Vaccheri, Giampaolo Ricci
PURPOSE: H1-antihistamines are commonly used in infants and children for the relief of histamine-mediated symptoms in a variety of conditions. Little is known about their safety profile in these patients. We performed a comparative analysis of the safety profiles of H1-antihistamines using data from the WHO database (VigiBase). METHODS: We selected adverse drug reaction (ADR) reports on H1-antihistamines in children (0-16 years) up to June 2014 from VigiBase. ADRs were codified according to MedDRA terminology...
June 27, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28628565/open-versus-laparoscopic-surgery-for-advanced-low-rectal-cancer-a-large-multicenter-propensity-score-matched-cohort-study-in-japan
#3
Koya Hida, Ryosuke Okamura, Yoshiharu Sakai, Tsuyoshi Konishi, Tomonori Akagi, Tomohiro Yamaguchi, Takashi Akiyoshi, Meiki Fukuda, Seiichiro Yamamoto, Michio Yamamoto, Tatsuto Nishigori, Kenji Kawada, Suguru Hasegawa, Satoshi Morita, Masahiko Watanabe
BACKGROUND: Laparoscopic surgery for rectal cancer is widely performed all over the world and several randomized controlled trials have been reported. However, the usefulness of laparoscopic surgery compared with open surgery has not been demonstrated sufficiently, especially for the low rectal area. OBJECTIVE: The aim of this study was to investigate the hypothesis that laparoscopic primary tumor resection is safe and effective when compared with the open approach for locally advanced low rectal cancer...
June 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28573803/effect-of-socio-economic-status-on-sleep
#4
Won Hee Seo, Jung Hyun Kwon, So-Hee Eun, Gunha Kim, Kyungdo Han, Byung Min Choi
AIM: Sufficient sleep is an important factor in physical and mental health. Sleep duration can be affected by socio-economic status (SES). This study aimed to examine the association between sleep duration and SES in Korean adolescents. METHODS: This study was conducted with 1608 adolescents aged 12-18 years, based on data from the 2010 to 2012 Korean National Health and Nutrition Examination Survey (KNHANES). Sleep duration was self-reported in hours and three SES indicators were used: household income, basic livelihood security programmes and type of health insurance...
June 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28505513/polyfluoroalkyl-substance-exposure-in-the-mid-ohio-river-valley-1991-2012
#5
Robert L Herrick, Jeanette Buckholz, Frank M Biro, Antonia M Calafat, Xiaoyun Ye, Changchun Xie, Susan M Pinney
BACKGROUND: Industrial discharges of perfluorooctanoic acid (PFOA) to the Ohio River, contaminating water systems near Parkersburg, WV, were previously associated with nearby residents' serum PFOA concentrations above US general population medians. Ohio River PFOA concentrations downstream are elevated, suggesting Mid-Ohio River Valley residents are exposed through drinking water. OBJECTIVES: Quantify PFOA and 10 other per- and polyfluoroalkyl substances (PFAS) in Mid-Ohio River Valley resident sera collected between 1991 and 2013 and determine whether the Ohio River and Ohio River Aquifer are exposure sources...
May 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28459136/pharmacokinetics-of-grapiprant-a-selective-ep4-prostaglandin-pge2-receptor-antagonist-after-2-mg-kg-oral-and-i-v-administrations-in-cats
#6
B Lebkowska-Wieruszewska, V De Vito, H Owen, A Poapholatep, M Giorgi
Drugs that provide effective analgesia in cats are limited. The aim of the study was to assess the pharmacokinetics of grapiprant after 2 mg/kg administration via p.o. and i.v. routes in cats. Six healthy adult cats were used according to an open, single-dose, two-treatment, two-period, randomized cross-over design. Cats were assigned to two treatment groups and administered with 2 mg/kg of grapiprant (pure powder) through p.o. and i.v. administration. Blood samples were collected at preassigned times and analysed by a validated HPLC method...
April 29, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28448761/sleeping-cupid-by-caravaggio-what-diagnosis
#7
Paolo Pozzilli, Marco Cappa
The Sleeping Cupid, by Italian painter Caravaggio is a masterpiece painted in 1608. Signs of an endocrine disease are hidden among the shadows of the painting. We decided to conduct a survey among endocrinologists practicing in Italy and asked them if they could identify a specific disease condition in Caravaggio's Sleeping Cupid. A total of 86 members from two Italian endocrine societies completed the survey, 67 from the Society of Endocrinology and 19 from the Society of Paediatric Endocrinology and Diabetology...
April 27, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28389420/the-reviews-are-in-a-qualitative-content-analysis-of-consumer-perspectives-on-apps-for-bipolar-disorder
#8
Jennifer Nicholas, Andrea S Fogarty, Katherine Boydell, Helen Christensen
BACKGROUND: The delivery of mobile health (mHealth) services is acceptable to mental health consumers. However, despite the benefits of accessibility, cost-effectiveness, anonymity, and ability to tailor content to individual needs, consumer engagement remains a hurdle for uptake and continued use. This may be unsurprising as few studies have examined app content from the consumer perspective or assessed consumer preferences for the content of apps for mental health management. An opportunity to examine consumer perspectives exists in using naturally generated data that is publically available in the Google Play and Apple app stores...
April 7, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28343818/comparative-performances-of-serologic-and-molecular-assays-for-detecting-human-t-lymphotropic-virus-type-1-and-type-2-htlv-1-and-htlv-2-in-patients-infected-with-human-immunodeficiency-virus-type-1-hiv-1
#9
Karoline Rodrigues Campos, Maria Gisele Gonçalves, Nadia Aparecida Costa, Adele Caterino-de-Araujo
The present study evaluated several techniques currently available (commercial kits and in-house assays) for diagnosing human T lymphotropic viruses types 1 and 2 in two groups of patients enrolled at HIV/AIDS specialized care services in São Paulo: Group 1 (G1), n=1608, 1237 male/371 female, median age 44.3 years old, majority using highly active antiretroviral therapy (HAART); G2, n=1383, 930 male/453 female, median age of 35.6 years old, majority HAART naïve. Enzyme immunoassays [(EIA) Murex and Gold ELISA] were employed for human T lymphotropic viruses types 1 and 2 screening; Western blotting (WB), INNO-LIA (LIA), real-time PCR pol (qPCR), and nested-PCR-RFLP (tax) were used to confirm infection...
March 24, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28341965/reliability-of-a-laryngo-pharyngeal-esthesiometer-and-a-method-for-measuring-laryngo-pharyngeal-mechano-sensitivity-in-a-prospectively-recruited-cohort-of-patients
#10
Luis F Giraldo-Cadavid, Javier Burguete, Felipe Rueda, Ana M Galvis, Natalia Castaneda, Luis M Agudelo-Otalora, William D Moscoso, Nelson Paez, Secundino Fernandez
There are not reliable methods for measuring laryngo-pharyngeal mechano-sensitivity (LPMS). We aimed to determine the reliability of a new method for measuring LPMS using a new laryngo-pharyngeal esthesiometer (LPEER) in a prospective cohort of dysphagic stroke and non-dysphagic patients. The patients underwent clinical and endoscopic evaluations of swallowing (FESSST). The LPMS assessments consisted of measurements by an expert and a novel rater of the laryngeal-adductor reflex threshold (LART), cough reflex threshold (CRT) and gag reflex threshold (GRT) using the LPEER...
March 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28332920/terminal-decline-of-episodic-memory-and-perceptual-speed-in-a-biracial-population
#11
Robert S Wilson, Kumar B Rajan, Lisa L Barnes, Willemijn Jansen, Priscilla Amofa, Jennifer Weuve, Denis A Evans
We compared trajectories of terminal cognitive decline in older Black (n = 3372) and White (n = 1756) persons from a defined population who completed tests of episodic memory and perceptual speed at 3-year intervals for up to 18 years. During a mean of 9.9 years of observation, 1608 Black persons and 902 White persons died. Preterminal decline of episodic memory did not differ by race. Terminal episodic memory decline began earlier in Black persons (mean of 4.3 years before death) than in White persons (mean = 3...
March 23, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28316621/impact-of-pressurized-intraperitoneal-aerosol-chemotherapy-on-quality-of-life-and-symptoms-in-patients-with-peritoneal-carcinomatosis-a-retrospective-cohort-study
#12
Hugo Teixeira Farinha, Fabian Grass, Amaniel Kefleyesus, Chahin Achtari, Benoit Romain, Michael Montemurro, Nicolas Demartines, Martin Hübner
Background. Peritoneal cancer treatment aims to prolong survival, but preserving Quality of Life (QoL) under treatment is also a priority. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel minimally invasive repeatable treatment modality. The aim of the present study was to assess QoL in our cohort of PIPAC patients. Methods. Analysis of all consecutive patients included from the start of PIPAC program (January 2015). QoL (0-100: optimal) and symptoms (no symptom: 0-100) were measured prospectively before and after every PIPAC procedure using EORTC QLQ-C30...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28223468/high-ambulatory-arterial-stiffness-index-is-an-independent-risk-factor-for-rapid-age-related-glomerular-filtration-rate-decline-in-the-general-middle-aged-population
#13
Bjørn Odvar Eriksen, Vidar Tor Nyborg Stefansson, Trond Geir Jenssen, Ulla Dorte Mathisen, Jørgen Schei, Marit Dahl Solbu, Tom Wilsgaard, Toralf Melsom
Arterial stiffness is a risk factor for cardiovascular and chronic kidney disease. However, the role of arterial stiffness as a predictor of the age-related glomerular filtration rate (GFR) decline in the general population remains unresolved because of difficulty in measuring GFR with sufficient precision in epidemiological studies. The ambulatory arterial stiffness index (AASI) is a proposed indicator of arterial stiffness easily calculated from ambulatory blood pressure. We investigated whether AASI could predict GFR decline measured as iohexol clearance in the general population...
April 2017: Hypertension
https://www.readbyqxmd.com/read/28221285/genome-wide-methylation-analysis-of-a-large-population-sample-shows-neurological-pathways-involvement-in-chronic-widespread-musculoskeletal-pain
#14
Gregory Livshits, Ida Malkin, Maxim B Freidin, Yudong Xia, Fei Gao, Jun Wang, Timothy D Spector, Alex MacGregor, Jordana T Bell, Frances M K Williams
Chronic widespread musculoskeletal pain (CWP), has a considerable heritable component, which remains to be explained. Epigenetic factors may contribute to and account for some of the heritability estimate. We analysed epigenome-wide methylation using MeDIPseq in whole blood DNA from 1708 monozygotic and dizygotic Caucasian twins having CWP prevalence of 19.9%. Longitudinally stable methylation bins (lsBINs), were established by testing repeated measurements conducted ≥3 years apart, n = 292. DNA methylation variation at lsBINs was tested for association with CWP in a discovery set of 50 monozygotic twin pairs discordant for CWP, and in an independent dataset (n = 1608 twins), and the results from the 2 samples were combined using Fisher method...
June 2017: Pain
https://www.readbyqxmd.com/read/28210739/retinal-oxidative-stress-at-the-onset-of-diabetes-determined-by-synchrotron-ftir-widefield-imaging-towards-diabetes-pathogenesis
#15
Ebrahim Aboualizadeh, Mahsa Ranji, Christine M Sorenson, Reyhaneh Sepehr, Nader Sheibani, Carol J Hirschmugl
Diabetic retinopathy is a microvascular complication of diabetes that can lead to blindness. In the present study, we aimed to determine the nature of diabetes-induced, highly localized biochemical changes in the neuroretina at the onset of diabetes. High-resolution synchrotron Fourier transform infrared (s-FTIR) wide field microscopy coupled with multivariate analysis (PCA-LDA) was employed to identify biomarkers of diabetic retinopathy with spatial resolution at the cellular level. We compared the retinal tissue prepared from 6-week-old Ins2(Akita/+) heterozygous (Akita/+, N = 6; a model of diabetes) male mice with the wild-type (control, N = 6) mice...
March 27, 2017: Analyst
https://www.readbyqxmd.com/read/28193168/genome-wide-snp-identification-linkage-map-construction-and-qtl-mapping-for-seed-mineral-concentrations-and-contents-in-pea-pisum-sativum-l
#16
Yu Ma, Clarice J Coyne, Michael A Grusak, Michael Mazourek, Peng Cheng, Dorrie Main, Rebecca J McGee
BACKGROUND: Marker-assisted breeding is now routinely used in major crops to facilitate more efficient cultivar improvement. This has been significantly enabled by the use of next-generation sequencing technology to identify loci and markers associated with traits of interest. While rich in a range of nutritional components, such as protein, mineral nutrients, carbohydrates and several vitamins, pea (Pisum sativum L.), one of the oldest domesticated crops in the world, remains behind many other crops in the availability of genomic and genetic resources...
February 13, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28153533/dysregulation-of-gene-expression-in-the-striatum-of-bachd-rats-expressing-full-length-mutant-huntingtin-and-associated-abnormalities-on-molecular-and-protein-levels
#17
Libo Yu-Taeger, Michael Bonin, Janice Stricker-Shaver, Olaf Riess, Hoa Huu Phuc Nguyen
Huntington disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the gene coding for the huntingtin protein (HTT). Mutant HTT (mHTT) has been proposed to cause neuronal dysfunction and neuronal loss through multiple mechanisms. Transcriptional changes may be a core pathogenic feature of HD. Utilizing the Affymetrix platform we performed a genome-wide RNA expression analysis in two BACHD transgenic rat lines (TG5 and TG9) at 12 months of age, both of which carry full-length human mHTT but with different expression levels...
January 30, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28152909/quality-assurance-metrics-in-clinical-trial-conduct
#18
Susanna Sellmann, Lindsay Philip, Cristina Guglielmi, Pamela Degendorfer, Amit M Oza
274 Background: Quality assurance (QA) in clinical trials is a safeguard against non-compliance, which impacts patient safety and data integrity. On an institutional level, compiling quality findings provides insight to gaps within existing processes, protocol compliance, and educational content. A QA metrics methodology has been implemented, which is streamlined with the ICH-GCP, and institutional Standard Operating Procedures (SOPs) and policies. METHODS: Individual findings are assigned an alphanumerical code, based on severity and category, and a reference for each Quality Assurance Review (QAR)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28131526/role-of-hysterectomy-and-lymphadenectomy-in-the-management-of-early-stage-borderline-ovarian-tumors
#19
Koji Matsuo, Hiroko Machida, Tsuyoshi Takiuchi, Brendan H Grubbs, Lynda D Roman, Anil K Sood, David M Gershenson
OBJECTIVE: To examine survival of women with stage T1 borderline ovarian tumors (BOTs) stratified by hysterectomy and lymphadenectomy status at surgery. METHODS: This is a retrospective study examining The Surveillance, Epidemiology, and End Results Program to identify surgically-treated stage T1 BOTs between 1988 and 2003 (n=4943). Association of surgery patterns and cause-specific survival (CSS) was examined in multivariable analysis. RESULTS: Mean age was 48...
March 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28057751/draft-genome-sequence-of-staphylococcus-aureus-1608-a-strain-that-caused-toxic-mastitis-in-twin-cows
#20
Marc J A Stevens, Roger Stephan, Sophia Johler
Staphylococcus aureus 1608 is a strain that caused a lethal mastitis in cows. Here, the draft genome sequence of the strain is presented.
January 5, 2017: Genome Announcements
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