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Newton B Wiggins, Daniel T Chong, Penny L Houghtaling, Ayman A Hussein, Walid Saliba, Joseph F Sabik, Oussama Wazni, Bruce L Wilkoff, Khaldoun G Tarakji
AIMS: The incidence, indications, and risk factors for cardiac implantable electronic device (CIED) implantation after cardiac surgery in an era with an aging population are not well described. There are limited data about the survival of these patients compared with a non-device group. We aimed to evaluate the incidence, indications, and risk factors for postoperative CIED implantation. We also assessed survival of these patients compared with a non-device group. METHODS: We included all patients without prior CIED implantation who underwent cardiac surgery at our institution from 1996 to 2008...
October 12, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Brendan F O'Connor, Donal Monaghan, Jonathan Cawley
Many proteins are glycosylated, that is to say they have bound sugars or glycans. Glycosylation is a non-template-driven posttranslation modification. It is now known that correct glycosylation is essential for the correct folding, solubility, stability, and immunogenicity of proteins. Here, we describe the technique of Lectin Affinity Chromatography (LAC), a procedure that has the ability to separate different glycans which are attached to proteins or lipids, termed glycoproteins or glycolipids, respectively...
2017: Methods in Molecular Biology
Andrzej Ossowski, Marta Diepenbroek, Tomasz Kupiec, Milena Bykowska-Witowska, Grażyna Zielińska, Teresa Dembińska, Andrzej Ciechanowicz
As the result of the communist terror in Poland, during years 1944-1956 more than 50,000 people died. Their bodies were buried secretly, and most places are still unknown. The research presents the results of identification of people buried in one of many mass graves, which were found at the cemetery Powązki Military in Warsaw, Poland. Exhumation revealed the remains of eight people, among which seven were identified genetically. Well-preserved molars were used for the study. Reference material was collected from the closest living relatives...
October 7, 2016: Journal of Forensic Sciences
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, John T Coppola, Sripal Bangalore
OBJECTIVES: Human immunodeficiency virus (HIV) seropositive individuals are predisposed to acute myocardial infarction (AMI). We sought to evaluate management strategies and outcomes of AMI in patients with HIV in the contemporary era. METHODS: We analyzed data from the National Inpatient Sample from 2002 to 2011 for patients admitted with AMI with or without HIV. Propensity-score matching was used to identify HIV seropositive AMI patients with similar characteristics who were managed invasively (cardiac catheterization, percutaneous coronary intervention [PCI], or coronary artery bypass graft surgery [CABG]) or conservatively...
October 2016: Journal of Invasive Cardiology
James Yan, Volker Musahl, Jeffrey Kay, Moin Khan, Nicole Simunovic, Olufemi R Ayeni
PURPOSE: This systematic review evaluates radiographic and clinical outcome reporting following navigated high tibial osteotomy (HTO). Conventional HTO was used as a control to compare outcomes and furthermore investigate the quality of evidence in studies reporting outcomes for navigated HTO. It was hypothesized that navigated HTO will show superior clinical and radiographic outcomes compared to conventional HTO. METHODS: Two independent reviewers searched PubMed, Ovid (MEDLINE), EMBASE, and Cochrane databases for studies reporting outcomes following navigated HTO...
September 24, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Ellen Klemera, Fiona M Brooks, Kayleigh L Chester, Josefine Magnusson, Neil Spencer
OBJECTIVES: The aim of this paper was to examine if the multiple environments of the adolescent including family, peers, school and neighbourhood might function as protective health assets against self-harming behaviour during adolescence. METHODS: The present study utilised data collected from 1608 respondents aged 15 years as part of the England WHO Health Behaviour in School-aged Children (HBSC) Study. Multilevel modelling was undertaken using the package MLwiN (version 2...
September 22, 2016: International Journal of Public Health
Mirjam C L Peek, Muneer Ahmed, Alessandro Napoli, Sasha Usiskin, Rose Baker, Michael Douek
PURPOSE: Breast-conserving surgery is effective for breast cancer treatment but is associated with morbidity in particular high re-excision rates. We performed a systematic review and meta-analysis to assess the current evidence for clinical outcomes with minimally invasive ablative techniques in the non-surgical treatment of breast cancer. METHODS: A systematic search of the literature was performed using PubMed and Medline library databases to identify all studies published between 1994 and May 2016...
October 2, 2016: International Journal of Hyperthermia
Juliana Maia, Andreia Soares da Silva, Rodrigo Feliciano do Carmo, Taciana Furtado de Mendonça, Luiz Henrique Maciel Griz, Patricia Moura, Francisco Bandeira
INTRODUCTION: Since there is evidence of the action of vitamin D as a modulator of insulin release and atherosclerosis, it may well be that the vitamin D receptor polymorphisms are associated with diabetes and its chronic complications. AIMS: To examine the associations between vitamin D receptor polymorphisms (FokI and TaqI) and Type 2 diabetes (T2DM) and its associated chronic complications in postmenopausal women. METHODS: This cross-sectional study analyzed 100 postmenopausal women with T2DM (mean age 65...
2016: Application of Clinical Genetics
Prathima Nandivada, Meredith A Baker, Paul D Mitchell, Alison A O'Loughlin, Alexis K Potemkin, Lorenzo Anez-Bustillos, Sarah J Carlson, Duy T Dao, Gillian L Fell, Kathleen M Gura, Mark Puder
BACKGROUND: Parenteral fish-oil (FO) therapy is a safe and effective treatment for intestinal failure-associated liver disease (IFALD). Patients whose cholestasis does not resolve with FO may progress to end-stage liver disease. OBJECTIVE: We sought to identify factors associated with the failure of FO therapy in treating IFALD to guide prognostication and referral guidelines. DESIGN: Prospectively collected data for patients treated with FO at Boston Children's Hospital from 2004 to 2014 were retrospectively reviewed...
September 2016: American Journal of Clinical Nutrition
Keith Hawton, Katrina G Witt, Tatiana L Taylor Salisbury, Ella Arensman, David Gunnell, Philip Hazell, Ellen Townsend, Kees van Heeringen
BACKGROUND: Self-harm (intentional acts of non-fatal self-poisoning or self-injury) is common, particularly in young adults aged 15-35 years, often repeated, and strongly associated with suicide. Effective aftercare of individuals who self-harm is therefore important. We have undertaken a Cochrane systematic review and meta-analysis of the effectiveness of psychosocial interventions for self-harm in adults. METHODS: We searched five electronic databases (CCDANCTR-Studies and References, CENTRAL, MEDLINE, Embase, and PsycINFO) between Jan 1, 1998, and April 29, 2015, for randomised controlled trials of psychosocial interventions for adults after a recent (within 6 months) episode of self-harm...
August 2016: Lancet Psychiatry
Stephan van Vliet, Russell S Emmons, Justin T Parel, Joseph W Beals, Luc J C van Loon, Scott A Paluska, Micheal De Lisio, Nicholas A Burd
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Joel Aissa, Johannes Boos, Christoph Schleich, Martin Sedlmair, Karl Krzymyk, Patric Kröpil, Gerald Antoch, Christoph Thomas
OBJECTIVES: Diagnostic accuracy of intraoperative computed tomography (CT) after deep brain stimulation (DBS) electrode placement is limited due to artifacts induced by the metallic hardware, which can potentially mask intracranial postoperative complications. Different metal artifact reduction (MAR) techniques have been introduced to reduce artifacts from metal hardware in CT. The purpose of this study was to assess the impact of a novel iterative MAR technique on image quality and diagnostic performance in the follow-up of patients with DBS electrode implementation surgery...
June 15, 2016: Investigative Radiology
Marco Moretto, Paolo Sonego, Stefania Pilati, Giulia Malacarne, Laura Costantini, Lukasz Grzeskowiak, Giorgia Bagagli, Maria Stella Grando, Claudio Moser, Kristof Engelen
Large-scale transcriptional studies aim to decipher the dynamic cellular responses to a stimulus, like different environmental conditions. In the era of high-throughput omics biology, the most used technologies for these purposes are microarray and RNA-Seq, whose data are usually required to be deposited in public repositories upon publication. Such repositories have the enormous potential to provide a comprehensive view of how different experimental conditions lead to expression changes, by comparing gene expression across all possible measured conditions...
2016: Frontiers in Plant Science
Laura E Gibbons, Rob Fredericksen, Joseph O Merrill, Mary E McCaul, Geetanjali Chander, Heidi Hutton, William B Lober, W Chris Mathews, Kenneth Mayer, Greer Burkholder, James H Willig, Michael J Mugavero, Michael S Saag, Mari M Kitahata, Todd C Edwards, Donald L Patrick, Heidi M Crane, Paul K Crane
BACKGROUND: At-risk alcohol use is important to identify in clinical settings to facilitate interventions. The Patient-Reported Outcomes Measurement Information System (PROMIS) Alcohol Use Short Form was developed through an item response theory process, but its utility as a screening instrument in clinical care has not been reported. OBJECTIVE: To determine the ability of the PROMIS Alcohol Use Short Form to identify people with current or future at-risk alcohol use defined by the Alcohol Use Disorders Identification Test consumption (AUDIT-C) instrument...
July 1, 2016: Drug and Alcohol Dependence
Hui Cai, Fei Ye, Angelika Michel, Gwen Murphy, Shizuka Sasazuki, Philip R Taylor, You-Lin Qiao, Sue K Park, Keun-Young Yoo, Sun Ha Jee, Eo Rin Cho, Jeongseon Kim, Sheau-Chiann Chen, Christian C Abnet, Shoichiro Tsugane, Qiuyin Cai, Xiao-Ou Shu, Wei Zheng, Michael Pawlita, Meira Epplein
BACKGROUND: Incidence and mortality rates for gastric cancer, the fifth most commonly diagnosed and third most deadly cancer worldwide, are highest in East Asia. We sought to identify gastric cancer risk biomarkers among eight prospective studies from China, Japan and Korea. METHODS: This pooled nested case-control study included 1608 incident non-cardia gastric cancer cases and 1958 matched controls. Pre-diagnostic antibody levels to 15 Helicobacter pylori proteins were assessed using multiplex serology...
June 2016: International Journal of Epidemiology
Pietro A Modesti, Andrea Colella, Dong Zhao
BACKGROUND: Despite the public health burden of atrial fibrillation (AF) and its complications in China, there is no literature on AF among Chinese living in Europe. The present study was performed to investigate the prevalence of and risk factors for AF in Chinese first generation migrants settled in Europe. METHODS: A cross-sectional survey was performed in 2014 on Chinese first generation migrants aged 16 to 59years settled in Prato (Italy) adopting principles of community based participatory research...
July 15, 2016: International Journal of Cardiology
Pietro A Modesti, Maria Calabrese, Eleonora Perruolo, Alessandro Bussotti, Danilo Malandrino, Mohamed Bamoshmoosh, Annibale Biggeri, Dong Zhao
Migration flows from China are largely directed towards the South of Europe, Chinese being now the third largest overseas-born population in Italy. The aim of the study was to investigate hypertension burden and self-reported sleep disorders among 1608 first-generation Chinese migrants aged 16 to 59 years settled in Prato and recruited in a cross-sectional survey. Hypertension was defined as systolic BP ≥ 140  mm Hg and/or diastolic BP ≥ 90  mm Hg or self-reported antihypertensive treatment; potential impact of sleep disorders was analyzed by logistic regression adjusted for age, sex, marital status, education, health insurance, current smoking, parental hypertension, alcohol drinking, overweight or obesity, central obesity, diabetes, high total cholesterol, and high triglycerides...
April 2016: Medicine (Baltimore)
Meiling Gao, Jennifer Ahern, Catherine P Koshland
Development in Chinese cities is resulting in a diversity of urban environments that may influence health. In a cross-sectional study of 1608 adults in 20 neighborhoods of Xi'an, China, we examined perceptions of neighborhoods using the NEWS-A survey and health-related quality of life (HRQOL) from the SF-12 across four types of neighborhoods: old/planned, old/unplanned, new/high density, and new/low density. Increased accessibility was significantly associated with both higher mental (range: 3.13-5.53 points) and physical (range: 2...
May 2016: Health & Place
Rafael Alis, Alejandro Santos-Lozano, Fabian Sanchis-Gomar, Helios Pareja-Galeano, Carmen Fiuza-Luces, Nuria Garatachea, Alejandro Lucia, Enzo Emanuele
Trace element bioavailability can play a role in several metabolic and physiological pathways known to be altered during the aging process. We aimed to explore the association of trace elements with increased lifespan by analyzing the circulating levels of seven trace elements (Cr, Cu, Fe, Mn, Mo, Se and Zn) in a cohort of healthy centenarians or 'dodgers' (≥100 years, free of major age-related diseases) in comparison with sex-matched younger elderly controls. Centenarians showed significant lower Cu (783...
May 2016: Journal of Trace Elements in Medicine and Biology
Eman A Hammad
BACKGROUND: Drug pricing is an example of a priority setting in a developing country with official requirements for the use of cost-effectiveness (CE) evidence. OBJECTIVE: To describe the role of economic evidence in drug pricing decisions in Jordan. METHODS: A prospective review of all applications submitted between November 2013 and May 2015 to the Jordan Food and Drug Association's drug pricing committee was carried out. All applications that involved requests for CE evidence were reviewed...
March 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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