N G Zaorsky, X Wang, E J Lehrer, C Lin, S M Garrett, Y Zhang, D DeGraff, D E Spratt, D M Trifiletti, A U Kishan, T N Showalter, H S M Park, J T Yang, M Wang
PURPOSE/OBJECTIVE(S): Staging for metastatic disease is unreliable; there is usually only one category of Stage IV in the American Joint Commission on Cancer (AJCC) 8th edition, but survival can range from weeks to years. We hypothesize that prognostication can be improved for metastatic disease by using common clinical covariates in a pan-cancer phenotype staging system. MATERIALS/METHODS: Latent class analysis was performed to explore the phenotypes using nationally representative patient data from the National Cancer Database (NCDB; n = 461,357, years 2010-2013, for the training cohort) and the Surveillance, Epidemiology, and End Results database (SEER; n = 106,595, years 2014-2015, for the validation cohort)...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics