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Columbia University Medical Center

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https://www.readbyqxmd.com/read/28419639/differences-in-intraoperative-hemodynamics-between-spinal-and-general-anesthesia-in-infants-undergoing-pyloromyotomy
#1
Caleb Ing, Lena S Sun, Alexander F Friend, Minjae Kim, Mitchell F Berman, William Paganelli, Guohua Li, Robert K Williams
BACKGROUND: Hypotension and bradycardia are known side effects of spinal anesthesia in pregnant women undergoing cesarean section and adults undergoing other surgical procedures. Whether children experience similar hemodynamic changes is unclear. AIMS: The purpose of this study is to evaluate hemodynamic effects of spinal anesthesia compared to general anesthesia in a cohort of healthy infants. METHODS: The University of Vermont Medical Center almost exclusively used spinal anesthesia for infant pyloromyotomy surgery between 2008 and 2013, while Columbia University Medical Center relied on general anesthesia...
April 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28406747/100-years-of-radiation-research-in-the-footsteps-of-failla
#2
Eric J Hall
Gioacchino Failla was initially appointed to operate the radon plant at Memorial Hospital in 1916. What to most people would have been a part-time temporary position was to him a career. He was not satisfied to simply fabricate radon seeds, he wanted to understand the physics and biology of the radiation emitted by the progeny of radium. His was not the first medical physics group in the United States, though it was one of the earliest, but it was the first to put such emphasis on the biological effects. After more than 28 years at Memorial Hospital, Failla moved his research group to Columbia University Medical Center and his pioneering work, blending physics and biology, has continued to date at Columbia by those that he trained or inspired, under three directors that followed him...
April 2017: Radiation Research
https://www.readbyqxmd.com/read/28399687/low-prevalence-of-pneumocystis-pneumonia-in-hospitalized-patients-with-systemic-lupus-erythematosus-review-of-a-clinical-data-warehouse
#3
T M Kapoor, P Mahadeshwar, S Nguyen, J Li, S Kapoor, J Bathon, J Giles, A Askanase
Objective In the era of powerful immunosuppression, opportunistic infections are an increasing concern in systemic lupus erythematosus. One of the best-studied opportunistic infections is Pneumocystis pneumonia; however, the prevalence of Pneumocystis pneumonia in systemic lupus erythematosus is not clearly defined. This study evaluates the prevalence of Pneumocystis pneumonia in hospitalized systemic lupus erythematosus patients, with a focus on validating the Pneumocystis pneumonia and systemic lupus erythematosus diagnoses with clinical information...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28323349/maternal-depression-during-pregnancy-is-associated-with-increased-birth-weight-in-term-infants
#4
Lisa Ecklund-Flores, Michael M Myers, Catherine Monk, Albany Perez, Hein J Odendaal, William P Fifer
Previous research of maternal depression during pregnancy suggests an association with low birth weight in newborns. Review of these studies reveals predominant comorbidity with premature birth. This current study examines antenatal depression and birth weight in term, medically low-risk pregnancies. Maternal physiological and demographic measures were collected as well. In total, 227 pregnant women were recruited to participate in four experimental protocols at Columbia University Medical Center. Results indicate that depressed pregnant women who carry to term had significantly higher heart rates, lower heart rate variability, and gave birth to heavier babies than those of pregnant women who were not depressed...
April 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28317473/the-columbia-bronx-va-amalgamative-clerkship-an-effective-12-week-integrated-longitudinal-clinical-experience
#5
Jillian Diuguid-Gerber, Samuel Porter, Samuel C Quiah, Katherine Nickerson, Deborah Jones, Zeena Audi, Boyd F Richards
BACKGROUND: Many medical schools have adopted the longitudinal integrated clerkship (LIC) model in response to calls for increased continuity in clinical learning environments. However, because of implementation challenges, such programs are not feasible at some institutions or are limited to a small number of students. OBJECTIVE: In January 2014, Columbia University College of Physicians and Surgeons (P&S) recognized the need to explore different LIC formats and began offering four, 12-week amalgamative clerkships (AC)...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28264146/visualization-and-tissue-classification-of-human-breast-cancer-images-using-ultrahigh-resolution-oct
#6
Xinwen Yao, Yu Gan, Ernest Chang, Hanina Hibshoosh, Sheldon Feldman, Christine Hendon
BACKGROUND AND OBJECTIVE: Breast cancer is one of the most common cancers, and recognized as the third leading cause of mortality in women. Optical coherence tomography (OCT) enables three dimensional visualization of biological tissue with micrometer level resolution at high speed, and can play an important role in early diagnosis and treatment guidance of breast cancer. In particular, ultra-high resolution (UHR) OCT provides images with better histological correlation. This paper compared UHR OCT performance with standard OCT in breast cancer imaging qualitatively and quantitatively...
March 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28243631/identifying-microrna-panels-specifically-associated-with-hepatocellular-carcinoma-and-its-different-etiologies
#7
Jing Shen, Abby B Siegel, Helen Remotti, Qiao Wang, Regina M Santella
AIM: Deregulation of microRNAs (miRNAs) expression has been identified in hepatocellular carcinoma (HCC), but few results are consistent. The objective of this study is to investigate "HCC tumor type specific" and "tumor common" miRNA panels. METHODS: The authors integrate and analyze clinical, etiologic and miRNA profiles data from 9 types of solid tumors in The Cancer Genome Atlas (TCGA) and HCC data from Columbia University Medical Center (CUMC). RESULTS: Levels of 33 miRNAs were significant different between HCC tumor and paired non-tumor tissues (over 2-fold changes) after Bonferroni correction for multiple comparisons, and most (28 miRNAs) were down-regulated in HCC tumors...
June 2016: Hepatoma Research
https://www.readbyqxmd.com/read/28242078/awake-extracorporeal-membrane-oxygenation-as-bridge-to-lung-transplantation-a-9-year-experience
#8
Mauer Biscotti, Whitney D Gannon, Cara Agerstrand, Darryl Abrams, Joshua Sonett, Daniel Brodie, Matthew Bacchetta
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is used as a bridge to lung transplantation, but characteristics that influence its success are poorly understood. This large, single-center experience evaluated the implementation and outcomes of ECMO in this setting. METHODS: Data were collected for patients at our institution (New York-Presbyterian Hospital/Columbia University Medical Center in New York) who received ECMO as a bridge to lung transplantation from January 1, 2007 through July 10, 2016...
February 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28212433/elevated-gm3-plasma-concentration-in-idiopathic-parkinson-s-disease-a-lipidomic-analysis
#9
Robin B Chan, Adler J Perotte, Bowen Zhou, Christopher Liong, Evan J Shorr, Karen S Marder, Un J Kang, Cheryl H Waters, Oren A Levy, Yimeng Xu, Hong Bin Shim, Itsik Pe'er, Gilbert Di Paolo, Roy N Alcalay
Parkinson's disease (PD) is a common neurodegenerative disease whose pathological hallmark is the accumulation of intracellular α-synuclein aggregates in Lewy bodies. Lipid metabolism dysregulation may play a significant role in PD pathogenesis; however, large plasma lipidomic studies in PD are lacking. In the current study, we analyzed the lipidomic profile of plasma obtained from 150 idiopathic PD patients and 100 controls, taken from the 'Spot' study at Columbia University Medical Center in New York. Our mass spectrometry based analytical panel consisted of 520 lipid species from 39 lipid subclasses including all major classes of glycerophospholipids, sphingolipids, glycerolipids and sterols...
2017: PloS One
https://www.readbyqxmd.com/read/28195937/an-updated-protocol-for-evaluating-chest-pain-and-managing-acute-coronary-syndromes
#10
Christopher R Kelly, Ajay J Kirtane, Jennifer Stant, Gregg W Stone, Robert M Minutello, S Chiu Wong, Honeyleen Manuzon, Roxanne Gerow-Smith, Nancy Kelley, LeRoy E Rabbani
Clinical pathways can optimize care both across and within institutions, but regular updates to these pathways based on new clinical trials, professional guidelines, and Food and Drug Administration approvals are essential. Herein we describe the most recent revisions to the New York-Presbyterian Hospital (Columbia University Medical Center and Weill Cornell Medical Center) clinical pathway for acute coronary syndromes and chest pain, which incorporates novel data regarding the timing and administration of P2Y12 inhibition (including the intravenous P2Y12 inhibitor cangrelor) and the appropriateness of prolonged (>1 year) dual antiplatelet therapy for the secondary prevention of ischemic events...
March 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/28176457/predictors-of-acupuncture-use-among-children-and-adolescents-with-cancer
#11
Sagar K Chokshi, Elena J Ladas, Katherine Taromina, Douglas McDaniel, Diane Rooney, Zhezhen Jin, Wei-Chun Hsu, Kara M Kelly
BACKGROUND: Evidence for the application of acupuncture in pediatric oncology is limited. We investigated the acceptance of acupuncture and factors associated with its use among children and adolescents with cancer. METHODS: Ninety acupuncture-naïve children receiving cancer treatment at Columbia University Medical Center (CUMC) provided consent/assent for participation. Participants could choose to receive or refuse integrative services offered at CUMC. Symptoms were collected for a 6-month period with the Memorial Symptom Assessment Scale (MSAS)...
February 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28152740/understanding-efficiency-of-chemotherapy-delivery-for-planned-chemotherapy-admission-at-columbia-university-medical-center
#12
Jason Dennis Wright, Sowmya Vasan, Alfred I Neugut, Jim Hu, Dawn L Hershman
206 Background: Delays in administration of planned in-patient chemotherapy can lead to prolonged length of stay (LOS), resulting in increased cost and risk of nosocomial infections and other complications. METHODS: We conducted a retrospective analysis of cancer patients admitted to Columbia University Medical Center, a tertiary care center, for planned chemotherapy from January 1, 2014 through December 31, 2014. Eligible patients were identified as cancer patients (via ICD9 codes) who were admitted directly to the inpatient hematology/oncology service with intravenous chemotherapy orders submitted within 24 hours of the admission...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28140790/50-years-of-the-radiological-research-accelerator-facility-raraf
#13
Stephen A Marino
The Radiological Research Accelerator Facility (RARAF) is in its 50th year of operation. It was commissioned on April 1, 1967 as a collaboration between the Radiological Research Laboratory (RRL) of Columbia University, and members of the Medical Research Center of Brookhaven National Laboratory (BNL). It was initially funded as a user facility for radiobiology and radiological physics, concentrating on monoenergetic neutrons. Facilities for irradiation with MeV light charged particles were developed in the mid-1970s...
April 2017: Radiation Research
https://www.readbyqxmd.com/read/28140788/100-years-of-radiation-research-in-the-footsteps-of-failla
#14
Eric J Hall
Gioacchino Failla was initially appointed to operate the radon plant at Memorial Hospital in 1916. What to most people would have been a part-time temporary position was to him a career. He was not satisfied to simply fabricate radon seeds, he wanted to understand the physics and biology of the radiation emitted by the progeny of radium. His was not the first medical physics group in the United States, though it was one of the earliest, but it was the first to put such emphasis on the biological effects. After more than 28 years at Memorial Hospital, Failla moved his research group to Columbia University Medical Center and his pioneering work, blending physics and biology, has continued to date at Columbia by those that he trained or inspired, under three directors that followed him...
January 31, 2017: Radiation Research
https://www.readbyqxmd.com/read/28116650/the-safety-of-resection-for-primary-central-nervous-system-lymphoma-a-single-institution-retrospective-analysis
#15
Michael Brendan Cloney, Adam M Sonabend, Jonathan Yun, Jingyan Yang, Fabio Iwamoto, Suprit Singh, Govind Bhagat, Peter Canoll, George Zanazzi, Jeffrey N Bruce, Michael Sisti, Sameer Sheth, E Sander Connolly, Guy McKhann
Surgical resection is not the standard of care for primary central nervous system lymphoma (PCNSL), as historical studies have demonstrated unfavorable complication rates and limited benefits. Some recent studies suggest that resection may provide a therapeutic benefit, yet the safety of these procedures has not been systematically investigated in the setting of modern neurosurgery. We examined the safety of surgical resection for PCNSL. We retrospectively analyzed all patients with PCNSL treated at Columbia University Medical Center between 2000 and 2015 to assess complications rates following biopsy or resection using the Glioma Outcomes Project system...
March 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28056461/predicting-post-transplant-recurrence-of-iga-nephropathy-the-importance-of-crescents
#16
Rupali S Avasare, Paul E Rosenstiel, Ziad S Zaky, Demetra S Tsapepas, Gerald B Appel, Glen S Markowitz, Andrew S Bomback, Pietro A Canetta
BACKGROUND: Most studies that have assessed the predictors of recurrent IgA nephropathy (IgAN) in the renal allograft have focused on post-transplant features. Identifying high-risk pre-transplant features of IgAN is useful for counseling patients and may help in tailoring post-transplant immunosuppression. METHODS: We investigated the pre-transplant clinical and biopsy features of 62 patients with IgAN who received transplants at Columbia University Medical Center from 2001 to 2012 and compared the characteristics and outcomes of patients with IgAN recurrence to those without recurrence...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28007021/implementation-of-next-generation-sequencing-into-pediatric-hematology-oncology-practice-moving-beyond-actionable-alterations
#17
Jennifer A Oberg, Julia L Glade Bender, Maria Luisa Sulis, Danielle Pendrick, Anthony N Sireci, Susan J Hsiao, Andrew T Turk, Filemon S Dela Cruz, Hanina Hibshoosh, Helen Remotti, Rebecca J Zylber, Jiuhong Pang, Daniel Diolaiti, Carrie Koval, Stuart J Andrews, James H Garvin, Darrell J Yamashiro, Wendy K Chung, Stephen G Emerson, Peter L Nagy, Mahesh M Mansukhani, Andrew L Kung
BACKGROUND: Molecular characterization has the potential to advance the management of pediatric cancer and high-risk hematologic disease. The clinical integration of genome sequencing into standard clinical practice has been limited and the potential utility of genome sequencing to identify clinically impactful information beyond targetable alterations has been underestimated. METHODS: The Precision in Pediatric Sequencing (PIPseq) Program at Columbia University Medical Center instituted prospective clinical next generation sequencing (NGS) for pediatric cancer and hematologic disorders at risk for treatment failure...
December 23, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27938905/the-effects-of-postoperative-hematocrit-on-shunt-occlusion-for-neonates-undergoing-single-ventricle-palliation
#18
Brett R Anderson, Victoria L Blancha, Jennifer M Duchon, Paul J Chai, David Kalfa, Emile A Bacha, Ganga Krishnamurthy, Veniamin Ratner
OBJECTIVES: Our primary objective was to test the effects of first postoperative hematocrit on early shunt occlusion for children undergoing systemic to pulmonary artery shunt placement. Because any intervention to reduce shunt occlusion is only beneficial if it reduces mortality or is, at least, mortality neutral, we also tested the effects of first postoperative hematocrit on in-hospital mortality. METHODS: We conducted a retrospective study on all neonates who underwent primary systemic to pulmonary artery shunt placement, with or without a Norwood/Damus-Kaye-Stansel procedure, at Columbia University Medical Center between January 2010 and July 2015...
April 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27932533/preoperative-proteinuria-and-reduced-glomerular-filtration-rate-predicts-renal-replacement-therapy-in-patients-supported-with-continuous-flow-left-ventricular-assist-devices
#19
Veli K Topkara, Ellie J Coromilas, Arthur Reshad Garan, Randall C Li, Francesco Castagna, Douglas L Jennings, Melana Yuzefpolskaya, Koji Takeda, Hiroo Takayama, Robert N Sladen, Donna M Mancini, Yoshifumi Naka, Jai Radhakrishnan, Paolo C Colombo
BACKGROUND: Renal failure requiring renal replacement therapy (RRT) has detrimental effects on quality of life and survival of patients with continuous-flow left ventricular assist devices (CF-LVADs). Current guidelines do not offer a decision-making algorithm for CF-LVAD candidates with poor baseline renal function. Objective of this study was to identify risk factors associated with RRT after CF-LVAD implantation. METHODS AND RESULTS: Three hundred and eighty-nine consecutive patients underwent contemporary CF-LVAD implantation at the Columbia University Medical Center between January 2004 and August 2015...
December 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27888180/northern-manhattan-hispanic-caregiver-intervention-effectiveness-study-protocol-of-a-pragmatic-randomised-trial-comparing-the-effectiveness-of-two-established-interventions-for-informal-caregivers-of-persons-with-dementia
#20
José A Luchsinger, Louis Burgio, Mary Mittelman, Ilana Dunner, Jed A Levine, Jian Kong, Stephanie Silver, Mildred Ramirez, Jeanne A Teresi
INTRODUCTION: The prevalence of dementia is increasing without a known cure, resulting in an increasing number of informal caregivers. Caring for a person with dementia results in increased stress and depressive symptoms. There are several behavioural interventions designed to alleviate stress and depressive symptoms in caregivers of persons with dementia with evidence of efficacy. Two of the best-known interventions are the New York University Caregiver Intervention (NYUCI) and the Resources for Enhancing Alzheimer's Caregivers Health (REACH)...
November 25, 2016: BMJ Open
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