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Dental genetics

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https://www.readbyqxmd.com/read/29141554/insight-into-the-role-of-long-non-coding-rnas-during-osteogenesis-in-mesenchymal-stem-cells
#1
Sibei Huo, Yachuan Zhou, Xinyu He, Mian Wan, Wei Du, Xin Xu, Ling Ye, Xuedong Zhou, Liwei Zheng
BACKGROUND: Long non-coding RNAs (LncRNAs) are non-protein coding transcripts longer than 200 nucleotides in length. Instead of being "transcriptional noise", lncRNAs are emerging as a key modulator in various biological processes and disease development. Mesenchymal stem cells can be isolated from various adult tissues, such as bone marrow and dental tissues. The differentiation processes into multiple lineages, such as osteogenic differentiation, are precisely orchestrated by molecular signals in both genetic and epigenetic ways...
November 15, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29139600/arcr-modulates-biofilm-formation-in-the-dental-plaque-colonizer-streptococcus-gordonii
#2
Jill C Robinson, Nadia Rostami, John Casement, Waldemar Vollmer, Alexander H Rickard, Nicholas S Jakubovics
Biofilm formation and cell-cell sensing by the pioneer dental plaque coloniser Streptococcus gordonii is dependent upon arginine. This study aimed to identify genetic factors linking arginine-dependent responses and biofilm formation in S. gordonii. Isogenic mutants disrupted in genes required for biosynthesis or catabolism of arginine, or for arginine-dependent gene regulation, were screened for their ability to form biofilms in a static culture model. Biofilm formation by a knockout mutant of arcR, encoding an arginine-dependent regulator of transcription, was reduced to <50% that of the wild-type whereas other strains were unaffected...
November 15, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29139104/ancestry-and-dental-development-a-geographic-and-genetic-perspective
#3
Brunilda Dhamo, Lea Kragt, Olja Grgic, Strahinja Vucic, Carolina Medina-Gomez, Fernando Rivadeneira, Vincent W V Jaddoe, Eppo B Wolvius, Edwin M Ongkosuwito
OBJECTIVE: In this study, we investigated the influence of ancestry on dental development in the Generation R Study. METHODS: Information on geographic ancestry was available in 3,600 children (1,810 boys and 1,790 girls, mean age 9.81 ± 0.35 years) and information about genetic ancestry was available in 2,786 children (1,387 boys and 1,399 girls, mean age 9.82 ± 0.34 years). Dental development was assessed in all children using the Demirjian method. The associations of geographic ancestry (Cape Verdean, Moroccan, Turkish, Dutch Antillean, Surinamese Creole and Surinamese Hindustani vs Dutch as the reference group) and genetic content of ancestry (European, African or Asian) with dental development was analyzed using linear regression models...
November 15, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29127774/characteristics-of-supernumerary-teeth-in-nonsyndromic-population-in-an-urban-dental-school-setting
#4
Mackensie McBeain, Michael Miloro
PURPOSE: The purpose of this study was to analyze the clinical records of all patients evaluated for supernumerary teeth at the University of Illinois-Chicago Department of Oral and Maxillofacial Surgery postgraduate clinic from January 1, 2010 to October 31, 2015 to determine the demographics of impacted supernumerary teeth among different ethnicities in the city of Chicago. MATERIALS AND METHODS: A retrospective case series was completed on patients eligible for inclusion in the study who had a diagnosis of at least 1 full bony impacted supernumerary tooth (D7240)...
October 16, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29127258/homozygous-mutation-in-cep19-a-gene-mutated-in-morbid-obesity-in-bardet-biedl-syndrome-with-predominant-postaxial-polydactyly
#5
Esra Yıldız Bölükbaşı, Sara Mumtaz, Muhammad Afzal, Ute Woehlbier, Sajid Malik, Aslıhan Tolun
BACKGROUND: Bardet-Biedl syndrome (BBS) is a ciliopathy with extensive phenotypic variability and genetic heterogeneity. We aimed to discover the gene mutated in a consanguineous kindred with multiple cases of a BBS phenotype. METHODS: SNP genotype data were used for linkage analysis and exome sequencing to identify mutations. Modelling and in silico analysis were performed to predict mutation severity. RESULTS: Patients had postaxial polydactyly plus variable other clinical features including rod-cone dystrophy, obesity, intellectual disability, renal malformation, developmental delay, dental anomalies, speech disorder and enlarged fatty liver...
November 10, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29121437/a-novel-pitx2-mutation-in-non-syndromic-oro-dental-anomalies
#6
Narin Intarak, Thanakorn Theerapanon, Chupong Ittiwut, Kanya Suphapeetiporn, Thantrira Porntaveetus, Vorasuk Shotelersuk
OBJECTIVE: To identify oro-dental characteristics and genetic etiology of a family affected with non-syndromic oro-dental anomalies. SUBJECTS AND METHODS: Physical and oral features were characterised. DNA was collected from an affected Thai family. Whole exome sequencing was employed to identify the pathogenic variants associated with inherited oro-dental anomalies. The presence of the identified mutation was confirmed by Sanger sequencing. RESULTS: We observed unique oro-dental manifestations including oligodontia, retained primary teeth, taurodont molars, peg-shaped maxillary central incisors, high attached frenum with nodule, and midline diastema in the proband and her mother...
November 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29118330/molecular-spectrum-of-secretome-regulates-the-relative-hepatogenic-potential-of-mesenchymal-stem-cells-from-bone-marrow-and-dental-tissue
#7
Ajay Kumar, Vinod Kumar, Vidya Rattan, Vivekananda Jha, Arnab Pal, Shalmoli Bhattacharyya
Liver regeneration is a spontaneous process that occurs after liver injury, but acute liver failure is a complex and fatal disease which is difficult to treat. Cell-based therapies are promising alternative therapeutic approach for liver failure and different cell sources have been tested in this regard. We investigated the comparative hepatogenic potential of human bone marrow stem cells (BMSC) with stem cells derived from human dental pulp (DPSC), apical papilla (SCAP) and follicle (DFSC) during this study...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114927/genetic-study-of-non-syndromic-tooth-agenesis-through-the-screening-of-paired-box-9-msh-homeobox-1-axin-2-and-wnt-family-member-10a-genes-a-case-series
#8
Marwa Haddaji Mastouri, Peter De Coster, Aicha Zaghabani, Frej Jammali, Nabiha Raouahi, Amina Ben Salem, Ali Saad, Paul Coucke, Dorra H'mida Ben Brahim
Non-syndromic tooth agenesis (NSTA) is the most common developmental anomaly in humans. Several studies have been conducted on dental agenesis and numerous genes have been identified. However, the pathogenic mechanisms responsible for NSTA are not clearly understood. We studied a group of 28 patients with sporadic NSTA and nine patients with a family history of tooth agenesis. We focused on four genes - paired box 9 (PAX9), Wnt family member 10A (WNT10A), msh homeobox 1 (MSX1), and axin 2 (AXIN2) - using direct Sanger sequencing of the exons and intron-exon boundaries...
November 8, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29103940/morphometric-behavioral-and-genomic-evidence-for-a-new-orangutan-species
#9
Alexander Nater, Maja P Mattle-Greminger, Anton Nurcahyo, Matthew G Nowak, Marc de Manuel, Tariq Desai, Colin Groves, Marc Pybus, Tugce Bilgin Sonay, Christian Roos, Adriano R Lameira, Serge A Wich, James Askew, Marina Davila-Ross, Gabriella Fredriksson, Guillem de Valles, Ferran Casals, Javier Prado-Martinez, Benoit Goossens, Ernst J Verschoor, Kristin S Warren, Ian Singleton, David A Marques, Joko Pamungkas, Dyah Perwitasari-Farajallah, Puji Rianti, Augustine Tuuga, Ivo G Gut, Marta Gut, Pablo Orozco-terWengel, Carel P van Schaik, Jaume Bertranpetit, Maria Anisimova, Aylwyn Scally, Tomas Marques-Bonet, Erik Meijaard, Michael Krützen
Six extant species of non-human great apes are currently recognized: Sumatran and Bornean orangutans, eastern and western gorillas, and chimpanzees and bonobos [1]. However, large gaps remain in our knowledge of fine-scale variation in hominoid morphology, behavior, and genetics, and aspects of great ape taxonomy remain in flux. This is particularly true for orangutans (genus: Pongo), the only Asian great apes and phylogenetically our most distant relatives among extant hominids [1]. Designation of Bornean and Sumatran orangutans, P...
October 31, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29102860/presence-of-dental-signs-of-congenital-syphilis-in-pre-modern-specimens
#10
REVIEW
Stella Ioannou, Renata J Henneberg, Maciej Henneberg
OBJECTIVE: Tooth morphology can vary due to genetic factors, infectious diseases and other environmental stresses. Congenital syphilis is known to interrupt tooth formation i.e. odontogenesis and amelogenesis, producing specific dental characteristics. Variation of those characteristics can occur, resulting in dental signs "not typical" of the disease, however, they are described in the 19th century literature. Past treatments of congenital syphilis with mercury also interrupted dental processes resulting in significantly different dental signs...
October 20, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29081304/genotype-and-genetic-variation-of-hcv-infections-with-low-risk-factors-in-putian-coastal-regions-china
#11
X M Li, R X Qiu, C H Song, Q H Huang, X D Wang, Z T Hu, X Z He, X Y Ye, X G Huang, F F Zheng, G X Lin
Hepatitis C virus (HCV) infection is one of the leading causes of death and morbidity associated with liver disease. Risk factors identified for the transmission of HCV include contaminated blood products, intravenous drug use, body piercing, an infected mother at birth, sexual activity, and dental therapy, among others. However, the exact diversity of the HCV genotype and genetic variation among patients with low-risk factors is still unknown. In this study, we briefly described and analysed the genotype distribution and genetic variation of HCV infections with low-risk factors using molecular biology techniques...
October 30, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29079615/%C3%AE-glucanase-activity-of-the-oral-bacterium-tannerella-forsythia-contributes-to-the-growth-of-a-partner-species-fusobacterium-nucleatum-in-co-biofilms
#12
Kiyonobu Honma, Angela Ruscitto, Ashu Sharma
Tannerella forsythia and Fusobacterium nucleatum are dental plaque bacteria implicated in the development of periodontitis. These two species have been shown to form synergistic biofilms and found to be closely associated in dental plaque biofilms. A number of genetic loci for TonB-dependent membrane receptors (TDR) for glycan acquisition, with many existing in association with genes coding for enzymes involved in the breakdown of complex glycans, have been identified in T. forsythia In this study, we focused on a locus, BFO_0186 -- BFO_0188, that codes for a predicted TDR-SusD transporter along with a putative β-glucan hydrolyzing enzyme (BFO_0186)...
October 27, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29068589/chosen-single-nucleotide-polymorphisms-snps-of-enamel-formation-genes-and-dental-caries-in-a-population-of-polish-children
#13
Karolina Gerreth, Katarzyna Zaorska, Maciej Zabel, Maria Borysewicz-Lewicka, Michał Nowicki
BACKGROUND: It is increasingly emphasized that the influence of a host's factors in the etiology of dental caries are of most interest, particularly those concerned with genetic aspect. OBJECTIVES: The aim of the study was to analyze the genotype and allele frequencies of single nucleotide polymorphisms (SNPs) in AMELX, AMBN, TUFT1, TFIP11, MMP20 and KLK4 genes and to prove their association with dental caries occurrence in a population of Polish children. MATERIAL AND METHODS: The study was performed in 96 children (48 individuals with caries - "cases" and 48 free of this disease - "controls"), aged 20-42 months, chosen out of 262 individuals who had dental examination performed and attended 4 day nurseries located in Poznań (Poland)...
September 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29044525/susceptibility-of-different-mouse-strains-to-peri-implantitis
#14
S Hiyari, A Naghibi, R Wong, R Sadreshkevary, L Yi-Ling, S Tetradis, P M Camargo, F Q Pirih
BACKGROUND AND OBJECTIVE: Peri-implantitis (PI) is an inflammatory condition that affects the tissues surrounding dental implants. Although the pathogenesis of PI is not fully understood, evidence suggests that the etiology is multifactorial and may include a genetic component. The aim of this study was to investigate the role of genetics in the development of peri-implantitis. MATERIAL AND METHODS: Four-week-old C57BL/6J, C3H/HeJ and A/J male mice had their left maxillary molars extracted...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29042739/robinow-syndrome-and-fusion-of-primary-teeth
#15
Priti Sushil Jain, Tejashri Shreyas Gupte, Abdulkadeer M Jetpurwala, Shely Pratik Dedhia
Managing patients with rare genetic disorders is a challenge that dentists face often. Robinow syndrome (RS) is one such rare genetic disorder with <200 cases reported worldwide. RS demonstrates multiple craniofacial abnormalities and orodental disorders, which need to be taken into consideration by a dental practitioner while rendering dental care.
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29042737/nance-horan-syndrome-a-rare-case-report
#16
Shambhu Sharma, Pankaj Datta, Janak Raj Sabharwal, Sonia Datta
Dentofacial anomalies may guide us to the diagnosis of many congenital and hereditary syndromes. A 9-year-old boy was diagnosed with Nance-Horan syndrome. This syndrome is an extremely rare X-linked genetic disorder which is entirely expressed in males with semi-dominant transmission which results from mutations occurring in male gametes. It is characterized by facial dysmorphism such as long face, prominent nose and mandibular prognathism, ocular abnormalities such as congenital cataract, microcornea, microphthalmia and strabismus, and dental anomalies including mulberry molars and screwdriver-shaped incisors...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29028630/ezh2-regulates-dental-pulp-inflammation-by-direct-effect-on-inflammatory-factors
#17
Tianqian Hui, Peng A, Yuan Zhao, Jing Yang, Ling Ye, Chenglin Wang
OBJECTIVE: Pulpitis is a multi-factorial disease that could be caused by complex interactions between genetics, epigenetics and environmental factors. We aimed to evaluate the role of Enhancer of Zeste Homolog 2 (EZH2) in the inflammatory response of human dental pulp cells (HDPCs) and dental pulp tissues. METHODS: The expressions of inflammatory cytokines in HDPCs treated by EZH2 complex or EZH2 siRNA with or without rhTNF-α were examined by quantitative real-time polymerase chain reaction (q-PCR)...
October 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29024454/disclosure-of-personalized-rheumatoid-arthritis-risk-using-genetics-biomarkers-and-lifestyle-factors-to-motivate-health-behavior-improvements-a-randomized-controlled-trial
#18
Jeffrey A Sparks, Maura D Iversen, Zhi Yu, Nellie A Triedman, Maria G Prado, Rachel Miller Kroouze, Sarah S Kalia, Michael L Atkinson, Elinor A Mody, Simon M Helfgott, Derrick J Todd, Paul F Dellaripa, Bonnie L Bermas, Karen H Costenbader, Kevin D Deane, Bing Lu, Robert C Green, Elizabeth W Karlson
OBJECTIVE: To determine the effect of disclosure of rheumatoid arthritis (RA) risk personalized with genetics, biomarkers, and lifestyle factors on health behavior intentions. METHODS: We performed a randomized controlled trial among first-degree relatives without RA. Subjects assigned to the Personalized Risk Estimator for RA (PRE-RA) group received the web-based PRE-RA tool for RA risk factor education and disclosure of personalized RA risk estimates including genotype/autoantibody results and behaviors (n=158)...
October 12, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28992378/grem2-nucleotide-variants-and-the-risk-of-tooth-agenesis
#19
Adrianna Mostowska, Barbara Biedziak, Małgorzata Zadurska, Agnieszka Bogdanowicz, Aneta Olszewska, Katarzyna Cieślińska, Ewa Firlej, Paweł P Jagodziński
OBJECTIVE: The etiology of tooth agenesis is multifactorial and still not fully understood. The aim of the study was to test whether variants of GREM2, encoding a BMP antagonist, are associated with the risk of this common dental anomaly in a Polish population. SUBJECTS AND METHODS: Direct sequencing of the GREM2 coding sequence including exon/intron boundaries was performed in 95 patients with both hypodontia and oligodontia. All identified GREM2 variants were then further tested in an independent group of patients (n=163) and controls (n=184)...
October 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28979012/focal-dermal-hypoplasia-goltz-syndrome-a-cross-sectional-study-from-eastern-india
#20
Sudip Kumar Ghosh, Abhijit Dutta, Sharmila Sarkar, Shanka Subhra Nag, Surajit Kumar Biswas, Prabhakar Mandal
INTRODUCTION: Focal dermal hypoplasia (Goltz syndrome), is an extremely rare genetic disorder characterized by distinct skin manifestations and a wide range of abnormalities involving the ocular, dental, skeletal, urinary, gastrointestinal, cardiovascular, and central nervous systems. The objective of the present series is to emphasize the different typical as well as unusual features of this rare syndrome. METHOLOGY: This cross-sectional observational study was performed over a period of 8 years in a tertiary care hospital of Eastern India...
September 2017: Indian Journal of Dermatology
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