Robert K Roden, Nathan Zuniga, Joshua C Wright, David H Parkinson, Fangfang Jiang, Leena M Patil, Rebecca S Burlett, Alyssa A Nitz, Joshua J Rogers, Jarett T Pittman, Kenneth L Virgin, P Christine Ackroyd, Samuel H Payne, John C Price, Kenneth A Christensen
BACKGROUND: Human tear protein biomarkers are useful for detecting ocular and systemic diseases. Unfortunately, existing tear film sampling methods (Schirmer strip; SS and microcapillary tube; MCT) have significant drawbacks, such as pain, risk of injury, sampling difficulty, and proteomic disparities between methods. Here, we present an alternative tear protein sampling method using soft contact lenses (SCLs). RESULTS: We optimized the SCL protein sampling in vitro and performed in vivo studies in 6 subjects...
March 13, 2024: Clinical Proteomics