Mariusz Kowalewski, Michalina M Kołodziejczak, Tomasz Urbanowicz, Maria Elena De Piero, Silvia Mariani, Michał Pasierski, Maged Makhoul, Maria Comanici, Emil Julian Dąbrowski, Matteo Matteucci, Giulio Massimi, Radosław Litwinowicz, Adam Kowalówka, Wojciech Wańha, Federica Jiritano, Gennaro Martucci, Giuseppe Maria Raffa, Pietro Giorgio Malvindi, Łukasz Kuźma, Piotr Suwalski, Roberto Lorusso, Paolo Meani, Harold Lazar
Despite evidence suggesting the benefit of prophylactic regional antibiotic delivery (RAD) to sternal edges during cardiac surgery, it is seldom performed in clinical practice. The value of topical vancomycin and gentamicin for sternal wound infections (SWI) prophylaxis was further questioned by recent studies including randomized controlled trials (RCTs). The aim of this systematic review and meta-analysis was to comprehensively assess the safety and effectiveness of RAD to reduce the risk of SWI.We screened multiple databases for RCTs assessing the effectiveness of RAD (vancomycin, gentamicin) in SWI prophylaxis...
April 27, 2024: Scientific Reports