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https://www.readbyqxmd.com/read/28429927/endovascular-correction-in-acute-bleeding-after-femoropopliteal-bypass-a-single-centre-experience
#1
Giulia Mazzitelli, Mariagnese Mele, Francesco Setacci, Giuseppe Galzerano, Gianmarco DE Donato, Domenico Benevento, Massimiliano W Guerrieri, Carlo Setacci
INTRODUCTION: The endovascular correction (EC) has emerged in recent years as a possible alternative to surgical revision (SR) in case of bleeding complications after peripheral bypass (PB) . The purpose of this study is to evaluate the efficacy and safety of EC compared to SR in case of bleeding complications of PB. METHODS: From January 2004 to December 2014, we have submitted 32 patients to surgery for acute bleeding in previous PB (25 venous bypass, in situ or reversed, 6 PTFE bypass and 1 composite bypass)...
April 21, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28420878/synergistic-antimicrobial-effects-of-silver-transition-metal-combinatorial-treatments
#2
Javier A Garza-Cervantes, Arturo Chávez-Reyes, Elena C Castillo, Gerardo García-Rivas, Oscar Antonio Ortega-Rivera, Eva Salinas, Margarita Ortiz-Martínez, Sara Leticia Gómez-Flores, Jorge A Peña-Martínez, Alan Pepi-Molina, Mario T Treviño-González, Xristo Zarate, María Elena Cantú-Cárdenas, Carlos Enrique Escarcega-Gonzalez, J Rubén Morones-Ramírez
Due to the emergence of multi-drug resistant strains, development of novel antibiotics has become a critical issue. One promising approach is the use of transition metals, since they exhibit rapid and significant toxicity, at low concentrations, in prokaryotic cells. Nevertheless, one main drawback of transition metals is their toxicity in eukaryotic cells. Here, we show that the barriers to use them as therapeutic agents could be mitigated by combining them with silver. We demonstrate that synergism of combinatorial treatments (Silver/transition metals, including Zn, Co, Cd, Ni, and Cu) increases up to 8-fold their antimicrobial effect, when compared to their individual effects, against E...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28407780/determining-the-gaps-between-cochrane-reviews-and-trials-of-effectiveness-of-interventions-for-acute-respiratory-infections-an-audit
#3
Jasmin Alloo, Sanya Vallath, Chris Del Mar, Matt Carter, Sarah Thorning, Justin Clark
BACKGROUND: Cochrane primarily aims to systematically review trials of effectiveness that are important to inform clinical decisions. Editorial groups support authors to achieve high-quality reviews and prioritise review proposals in their clinical domain that are submitted or elicited. Prioritising proposals requires two approaches, identifying (1) clinical practises for which the evidence of effectiveness is uncertain and (2) interventions in which there are trials of effectiveness (especially randomised controlled trials (RCTs)) not systematically reviewed...
April 13, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28407419/antibiotic-treatment-of-biofilm-infections
#4
REVIEW
Oana Ciofu, Estrella Rojo-Molinero, María D Macià, Antonio Oliver
Bacterial biofilms are associated with a wide range of infections, from those related to exogenous devices, such as catheters or prosthetic joints, to chronic tissue infections such as those occurring in the lungs of cystic fibrosis patients. Biofilms are recalcitrant to antibiotic treatment due to multiple tolerance mechanisms (phenotypic resistance). This causes persistence of biofilm infections in spite of antibiotic exposure which predisposes to antibiotic resistance development (genetic resistance). Understanding the interplay between phenotypic and genetic resistance mechanisms acting on biofilms, as well as appreciating the diversity of environmental conditions of biofilm infections which influence the effect of antibiotics are required in order to optimize the antibiotic treatment of biofilm infections...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28407169/collagen-cross-linking-with-photoactivated-riboflavin-pack-cxl-for-bacterial-keratitis-after-small-incision-lenticule-extraction-smile
#5
Tommy C Y Chan, Vanissa W S Chow, Vishal Jhanji
PURPOSE: To report a case of infectious keratitis after small incision lenticule extraction (SMILE) treated with collagen cross-linking with photoactivated riboflavin (PACK-CXL). METHODS: Case report and literature review. RESULTS: A patient presented with culture-proven bacterial keratitis 5 days after SMILE was treated with fortified topical antibiotics and PACK-CXL. Irrigation of the corneal cap-stromal bed interface, which can be difficult and affect visual outcomes, was not performed...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28405552/over-the-counter-and-prescription-medications-for-acne-a-cross-sectional-survey-in-a-sample-of-university-students-in-saudi-arabia
#6
Mohja D Alshehri, Abdulsalam T Almutairi, Asma M Alomran, Batool A Alrashed, Feroze Kaliyadan
INTRODUCTION AND BACKGROUND: Acne is a very common dermatological condition found among the adolescent population in Saudi Arabia. Many patients with acne try various forms of self-medication, over the counter medicines (OTC), and prescription medicines for the same. MATERIALS AND METHODS: This was a cross-sectional study among university students in the Kingdom of Saudi Arabia (KSA). A validated questionnaire was distributed to a convenience sample of university students to evaluate their knowledge and attitudes towards OTC (mainly) as well as prescription medicine for acne...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28402472/direct-sternal-administration-of-vancomycin-and-gentamicin-during-closure-prevents-wound-infection%C3%A2
#7
Martin Andreas, Moritz Muckenhuber, Doris Hutschala, Alfred Kocher, Florian Thalhammer, Paul Vogt, Tatjana Fleck, Guenther Laufer
OBJECTIVES: Deep sternal wound infection is still a major complication in patients undergoing cardiac surgery. We previously identified mammary artery harvesting as a risk factor for decreased antibiotic tissue penetration. In addition, other risk factors including diabetes may inhibit sufficient tissue penetration of perioperative antibiotic prophylaxis. A novel closure protocol applying 2 topical antibiotics and further recommendations for sternal wiring was introduced at our department to decrease the incidence of sternal wound infections...
April 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28400686/convergence-of-minds-for-better-patient-outcome-in-intensive-care-unit-infections
#8
Chand Wattal, Yash Javeri, Neeraj Goel, Debashish Dhar, Sonal Saxena, Sarman Singh, Jaswinder Kaur Oberoi, B K Rao, Purva Mathur, Vikas Manchanda, Vivek Nangia, Arti Kapil, Ashok Rattan, Supradip Ghosh, Omender Singh, Vinod Singh, Iqbal Kaur, Sanghamitra Datta, Sharmila Sen Gupta
BACKGROUND: There is emergence of resistance to the last-line antibiotics such as carbapenems in Intensive Care Units (ICUs), leaving little effective therapeutic options. Since there are no more newer antibiotics in the armamentarium in the near future, it has become imperative that we harness the interdisciplinary knowledge for the best clinical outcome of the patient. AIMS: The aim of the conference was to utilize the synergies between the clinical microbiologists and critical care specialists for better patient care and clinical outcome...
March 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28398420/clindamycin-phosphate-tretinoin-combination-gel-revisited-status-report-on-a-specific-formulation-used-for-acne-treatment
#9
James Q Del Rosso
Topical agents, including retinoids and antibiotics, are commonly used to treat acne vulgaris (AV) and remain as components of acne treatment guidelines. Approved topical combination formulations offer the advantages of established efficacy, decreased frequency of application, and improved convenience for patients. This article discusses both clindamycin phosphate (CP) and tretinoin (Tret) as components of a topical aqueous-based combination gel that has been shown to be effective, safe, and well tolerated for treatment of facial AV...
March 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28396543/a-topical-hydrogel-with-deferiprone-and-gallium-protoporphyrin-targets-bacterial-iron-metabolism-and-has-antibiofilm-activity
#10
Katharina Richter, Nicky Thomas, Jolien Claeys, Jonathan McGuane, Clive A Prestidge, Tom Coenye, Peter-John Wormald, Sarah Vreugde
Many infectious diseases are associated with multidrug-resistant (MDR) bacteria residing in biofilms that require high antibiotic concentrations. Whilst oral drug-delivery is frequently ineffective, topical treatments have the potential to deliver higher drug concentrations to the infection-site while reducing systemic side-effects.This study determined the antibiofilm activity of a surgical wound-gel loaded with the iron-chelator deferiprone (Def) and the heme-analogue gallium-protoporphyrin (GaPP), alone and in combination with ciprofloxacin...
April 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28396114/surgery-related-contact-dermatitis-a-review-of-potential-irritants-and-allergens
#11
Kevin A Cook, John M Kelso
Surgical procedures utilize an increasing number of medical products including antiseptics, anesthetics, gloves, suture materials, tissue adhesives, topical antibiotics, and bandages. Many of these products have irritant potential. Allergic contact dermatitis has also been reported. This review covers preoperative, operative, and postoperative exposures that may result in contact dermatitis. Testing with standard patch panels such as T.R.U.E. Test and the North American Contact Dermatitis Group 65 allergen series does not evaluate for all relevant contactants...
April 7, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28394180/antibiotic-treatment-failure-when-consulting-patients-with-respiratory-tract-infections-in-general-practice-a-qualitative-study-to-explore-danish-general-practitioners-perspectives
#12
Margrethe Bordado Sköld, Rune Aabenhus, Ann Dorrit Guassora, Marjukka Mäkelä
BACKGROUND: Prescribing antibiotics for acute respiratory tract infections (RTIs) is common in primary healthcare although most of these infections are of viral origin and antibiotics may not be helpful. Some of these prescriptions will not be associated with a quick recovery, and might be regarded as cases of antibiotic treatment failure (ATF). OBJECTIVES: We studied antibiotic treatment failure in patients with acute RTIs from a general practitioner (GP) perspective, aiming to explore (i) GPs' views of ATF in primary care; (ii) how ATF influences the doctor-patient relationship; and (iii) GPs' understanding of patients' views of ATF...
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/28392838/global-gene-expression-in-escherichia-coli-isolated-from-the-diseased-ocular-surface-of-the-human-eye-with-a-potential-to-form-biofilm
#13
Konduri Ranjith, Kotakonda Arunasri, Gundlapally Sathyanarayana Reddy, HariKrishna Adicherla, Savitri Sharma, Sisinthy Shivaji
BACKGROUND: Escherichia coli, the gastrointestinal commensal, is also known to cause ocular infections such as conjunctivitis, keratitis and endophthalmitis. These infections are normally resolved by topical application of an appropriate antibiotic. But, at times these E. coli are resistant to the antibiotic and this could be due to formation of a biofilm. In this study ocular E. coli from patients with conjunctivitis, keratitis or endophthalmitis were screened for their antibiotic susceptibility and biofilm formation potential...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28390069/antimicrobial-agents-for-preventing-peritonitis-in-peritoneal-dialysis-patients
#14
REVIEW
Denise Campbell, David W Mudge, Jonathan C Craig, David W Johnson, Allison Tong, Giovanni Fm Strippoli
BACKGROUND: Peritoneal dialysis (PD) is an important therapy for patients with end-stage kidney disease and is used in more than 200,000 such patients globally. However, its value is often limited by the development of infections such as peritonitis and exit-site and tunnel infections. Multiple strategies have been developed to reduce the risk of peritonitis including antibiotics, topical disinfectants to the exit site and antifungal agents. However, the effectiveness of these strategies has been variable and are based on a small number of randomised controlled trials (RCTs)...
April 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28389920/raman-microspectroscopy-surface-enhanced-raman-scattering-microspectroscopy-and-stable-isotope-raman-microspectroscopy-for-biofilm-characterization
#15
REVIEW
Natalia P Ivleva, Patrick Kubryk, Reinhard Niessner
Biofilms represent the predominant form of microbial life on our planet. These aggregates of microorganisms, which are embedded in a matrix formed by extracellular polymeric substances, may colonize nearly all interfaces. Detailed knowledge of microorganisms enclosed in biofilms as well as of the chemical composition, structure, and functions of the complex biofilm matrix and their changes at different stages of the biofilm formation and under various physical and chemical conditions is relevant in different fields...
April 7, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28389164/bactericidal-activity-and-post-antibiotic-effect-of-ozenoxacin-against-propionibacterium-acnes
#16
Shoji Kanayama, Kazuaki Okamoto, Fumiaki Ikeda, Ritsuko Ishii, Tatsumi Matsumoto, Naoki Hayashi, Naomasa Gotoh
Ozenoxacin, a novel non-fluorinated topical quinolone, is used for the treatment of acne vulgaris in Japan. We investigated bactericidal activity and post-antibiotic effect (PAE) of ozenoxacin against Propionibacterium acnes, a major causative bacterium of acne vulgaris. The minimum inhibitory concentrations (MICs) of ozenoxacin against 3 levofloxacin-susceptible strains (MIC of levofloxacin; ≤4 μg/mL) and 3 levofloxacin-resistant strains (MIC of levofloxacin; ≥8 μg/mL) ranged from 0.03 to 0.06 μg/mL and from 0...
April 4, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28389018/topical-drug-therapies-for-chronic-rhinosinusitis
#17
REVIEW
Lauren J Luk, John M DelGaudio
Chronic rhinosinusitis is recognized as an inflammatory syndrome involving the nose and paranasal sinuses of multifactorial etiology. Research has demonstrated a complex interplay between host factors, microbiota, environmental exposures, and epigenetics resulting in chronic mucosal inflammation. The mainstay of medical therapy addresses this inflammation. In previously operated sinuses this includes topical saline and corticosteroids, reserving antibiotics for culture-directed acute exacerbations. Topical antiinflammatory therapies allow increased local concentration of drugs while minimizing side effects...
April 4, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28387604/des-ncrna-a-knowledgebase-for-exploring-information-about-human-micro-and-long-noncoding-rnas-based-on-literature-mining
#18
Adil Salhi, Magbubah Essack, Tanvir Alam, Vladan P Bajic, Lina Ma, Aleksandar Radovanovic, Benoit Marchand, Sebastian Schmeier, Zhang Zhang, Vladimir B Bajic
Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding miRNAs and lncRNAs from the plethora of published ncRNA-related research, we developed DES-ncRNA ( www...
April 7, 2017: RNA Biology
https://www.readbyqxmd.com/read/28378244/ventilator-associated-pneumonia-by-methicillin-susceptible-staphylococcus-aureus-do-minimum-inhibitory-concentrations-to-vancomycin-and-daptomycin-matter
#19
J Ruiz-Ramos, P Vidal-Cortés, A Díaz-Lamas, R Reig-Valero, F Roche-Campo, M Del Valle-Ortiz, X Nuvials-Casals, M Ortiz-Piquer, D Andaluz-Ojeda, L Tamayo-Lomas, M A Blasco-Navalpotro, M Rodriguez-Aguirregabiria, J Aguado, P Ramirez
The use of vancomycin minimum inhibitory concentration (MIC) as an outcome predictor in patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia has become an important topic for debate in the last few years. Given these previous results, we decided to investigate whether MICs to vancomycin or daptomycin had any effect on the evolution of patients with ventilator-associated pneumonia (VAP) due to MSSA. An observational, retrospective, multicenter study was conducted among patients with MSSA VAP...
April 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28375402/hot-topics-in-primary-care-community-acquired-bacterial-pneumonia-is-there-anything-new
#20
REVIEW
Hans Liu
The management of patients with community-acquired pneumonia (CAP) is an ongoing challenge in the primary care setting. This is due, in part, to the fact that management guidelines in the United States were published nearly a decade ago. Furthermore, there has been a dearth of new treatments. But that may be about to change. Management guidelines are being updated by the Infectious Diseases Society of America (IDSA) and the American Thoracic Society (ATS) and are expected to be released this summer. In addition, several new antibiotics for the treatment of CAP are on the horizon...
April 2017: Journal of Family Practice
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