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https://www.readbyqxmd.com/read/28428072/membrane-lipid-alterations-in-the-metabolic-syndrome-and-the-role-of-dietary-oils
#1
REVIEW
Javier S Perona
The metabolic syndrome is a cluster of pathological conditions, including hypertension, hyperglycemia, hypertriglyceridemia, obesity and low HDL levels that is of great concern worldwide, as individuals with metabolic syndrome have an increased risk of type-2 diabetes and cardiovascular disease. Insulin resistance, the key feature of the metabolic syndrome, might be at the same time cause and consequence of impaired lipid composition in plasma membranes of insulin-sensitive tissues like liver, muscle and adipose tissue...
April 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28423036/metabolic-syndrome-serum-uric-acid-and-renal-risk-in-patients-with-t2d
#2
Francesca Viazzi, Pamela Piscitelli, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina Russo, Pietro Guida, Paola Fioretto, Salvatore De Cosmo, Roberto Pontremoli
BACKGROUND AND AIMS: Metabolic Syndrome (Mets) and increased serum uric acid (SUA), are well known renal risk predictors and often coexist in patients with type 2 diabetes (T2D). Whether they independently contribute to the onset of CKD is at present unclear. METHODS AND RESULTS: Within the AMD Annals database we identified patients with T2D and normal renal function and urine albumin excretion at baseline and regular follow-up visits during a 4-year period. Blood pressure, BMI, HDL, triglycerides, and SUA were available in 14,267 patients...
2017: PloS One
https://www.readbyqxmd.com/read/28421790/abdominal-obesity-is-strongly-associated-to-blood-pressure-in-young-mexicans
#3
Rene Urquidez Romero, Miguel Murguía Romero, Julián Esparza Romero, Beatriz Araceli Díaz Torres, Alejandra Rodríguez Tadeo, Gabriel Medrano Donlucas, Arnulfo Ramos Jiménez, Abraham Wall Medrano, Itzell A Gallardo Ortíz, Diana C Tapia-Pancardo C Tapia Pancardo, A René Méndez Cruz, J Rafael Jiménez Flores, Rafael Villalobos Molina
OBJECTIVE: The objective of this study was to determine associations between abdominal obesity (AOb) and the other components of metabolic syndrome (MetS) in young Mexicans in a cross-sectional survey completed during a 4 year period. METHODS: This cross-sectional study reports on components and prevalence of MetS by using Alberti et al. (16) criteria, as well as association between AOb and elevated blood pressure (BP) of 2,993 Mexican university students, ages 17 to 25 years (66% women) from central and northern Mexico, over a 4-year survey (2010-2013)...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28414931/human-adipose-tissue-levels-of-persistent-organic-pollutants-and-metabolic-syndrome-components-combining-a-cross-sectional-with-a-10-year-longitudinal-study-using-a-multi-pollutant-approach
#4
Vicente Mustieles, Mariana F Fernández, Piedad Martin-Olmedo, Beatriz González-Alzaga, Andrés Fontalba-Navas, Russ Hauser, Nicolás Olea, Juan P Arrebola
We aimed to assess the influence of long-term exposure to POPs on the risk of metabolic syndrome, combining a cross-sectional with a 10-year longitudinal follow-up design. Residues of eight POPs were quantified in adipose tissue samples from 387 participants recruited between 2003 and 2004 in Granada province (Spain). The outcome ("metabolically compromised") was defined as having ≥1 diagnosis of type 2 diabetes, hypertension, hypertriglyceridemia, and/or low HDL cholesterol. The cross-sectional analysis was conducted in the initial cohort, while the 10-year longitudinal analysis was conducted in those 154 participants free of any of the so-mentioned metabolic diseases and classified as "metabolically healthy" at recruitment...
April 14, 2017: Environment International
https://www.readbyqxmd.com/read/28410864/-prevalence-of-cardiovascular-risk-factors-in-urban-and-rural-communities-in-the-wilaya-of-tlemcen-algeria-a-comparative-study
#5
L Boukli Hacène, M-A Khelil, D Chabane Sari, K Meguenni, A Meziane Tani
BACKGROUND: In Algeria, few studies have been conducted to determine the prevalence of genetic and environmental risk factors of cardiovascular diseases as a function of residence. The objective of this study was therefore to determine the prevalence of cardiovascular risk factors according to sex and age in urban and rural communities in the Wilaya of Tlemcen (Algeria). MATERIAL AND METHODS: A population survey was conducted on a representative sample of 864 individuals aged 20years and over, among inhabitants in urban and rural communes in the Wilaya of Tlemcen...
April 11, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28399925/human-serum-rnase-l-level-is-inversely-associated-with-metabolic-syndrome-and-age
#6
Yi-Ting Wang, Ping-Huei Tseng, Chi-Ling Chen, Der-Sheng Han, Yu-Chiao Chi, Fen-Yu Tseng, Wei-Shiung Yang
BACKGROUND: Ribonuclease-L (RNase-L) was known to be a ubiquitous enzyme involved in several cellular functions, especially innate immunity. It was recently shown to participate in adipogenesis in rodents. Here, we developed a method to measure serum levels of RNase-L and analyzed the relationship between RNase-L and metabolic syndrome (MetS). METHODS: A total of 396 subjects were recruited from a health check-up program. An in-house RNase-L immunoassay was developed...
April 11, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28376848/prevalence-and-pattern-of-dyslipidemia-in-nepalese-individuals-with-type-2-diabetes
#7
Daya Ram Pokharel, Dipendra Khadka, Manoj Sigdel, Naval Kishor Yadav, Shreedhar Acharya, Ramchandra Kafle, Ravindra Mohan Sapkota, Tara Sigdel
BACKGROUND: Atherogenic dyslipidemia is an important modifiable risk factor for cardiovascular disease among patients of type 2 diabetes mellitus. Timely detection and characterization of this condition help clinicians estimate future risk of cardiovascular disease and take appropriate preventive measures. The aim of this study was to determine the prevalence, pattern and predictors of dyslipidemia in a cohort of Nepalese patients with type 2 diabetes. RESULTS: We found mixed dyslipidemia as the most prevalent (88...
April 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28376747/benign-prostatic-enlargement-can-be-influenced-by-metabolic-profile-results-of-a-multicenter-prospective-study
#8
Mauro Gacci, Arcangelo Sebastianelli, Matteo Salvi, Cosimo De Nunzio, Linda Vignozzi, Giovanni Corona, Tommaso Jaeger, Tommaso Chini, Giorgio Ivan Russo, Mario Maggi, Giuseppe Morgia, Andrea Tubaro, Marco Carini, Sergio Serni
BACKGROUND: In last years Metabolic Syndrome (MetS) has been closely associated to Benign Prostatic Enlargement (BPE) Aim of our study is to evaluate the effect of MetS and each single MetS parameter on prostate growth in men surgically treated for BPE. METHODS: Overall, 379 men were prospectively enrolled in two tertiary referral centers. Calculated prostate volume (PV) was measured with transrectal US defining the antero-posterior (AP), the cranio-caudal (CC) and the latero-lateral (LL) diameters through the ellipsoid formula, while raw PV was calculated by suprapubic US...
April 4, 2017: BMC Urology
https://www.readbyqxmd.com/read/28371687/cumulative-incidence-and-risk-factors-of-prediabetes-and-type-2-diabetes-in-a-singaporean-malay-cohort
#9
Ryan E K Man, Sabanayagam Charumathi, Alfred Tau Liang Gan, Eva K Fenwick, Ching Siong Tey, Jacqueline Chua, Tien-Yin Wong, Ching-Yu Cheng, Ecosse L Lamoureux
AIMS: The aim of this work was to determine the cumulative incidence and independent risk factors of prediabetes and type 2 diabetes (T2DM) in a well-characterized cohort of Malays in Singapore. METHODS: We included 1137 participants (mean age [SD]: 55 (10) years; 53.6% female) without diabetes (DM) at baseline from the Singapore Malay Eye Study, a population-based longitudinal study with baseline (2004-2006), and follow-up (2010-2013) examinations. Prediabetes was defined as an HbA1c between 5...
March 22, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28367205/lipid-abnormalities-in-patients-with-rheumatoid-arthritis
#10
Uzma Erum, Tasnim Ahsan, Danish Khowaja
OBJECTIVE: To determine the frequency of dyslipidemia in patients with Rheumatoid Arthritis. METHODS: This is a prospective, cross-sectional, observational study, conducted at the 'Rheumatology Clinic' of Jinnah Postgraduate Medical Center (JPMC), Karachi, from November 2013 to May 2014. A total of 200 patients of Rheumatoid Arthritis (RA), diagnosed according to the ACR/EULAR criteria 2010, were included in the study. Laboratory investigations including creatinine, ALT, CBC, TSH and fasting lipid profile (LDL, HDL, and Total cholesterol) were done for all patients...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28362975/gstm1-polymorphism-in-patients-with-clinical-manifestations-of-atherosclerosis
#11
D A Rodrigues, J V M Martins, K S F E Silva, I R Costa, M H Lagares, F L Campedelli, A M Barbosa, M P de Morais, K K V O Moura
Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include hypertension, smoking, obesity, high LDL and low HDL cholesterol levels, sedentary lifestyle, and stress; the non-modifiable factors include diabetes mellitus, family history of hypertension and heart disease, thrombophilia, sex, age, and genetic factors...
March 15, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28361809/association-of-non-alcoholic-fatty-liver-disease-and-cardiometabolic-risk-factors-with-early-atherosclerosis-in-an-adult-population-in-southern-italy
#12
Carmelo Antonio Caserta, Alfonso Mele, Pasquale Surace, Luigina Ferrigno, Angela Amante, Arianna Messineo, Carmelo Vacalebre, Fulvia Amato, Damiano Baldassarre, Mauro Amato, Fabrizio Marcucci, Massimo Zuin
AIM: The prevalence of risk factors for cardiovascular and metabolic diseases was investigated in an adult population of the city of Cittanova, Southern Italy. METHODS: The study was conducted among 992 randomly selected adults aged 18-75 years, between April 2009 and January 2011. RESULTS: Prevalence rates of non-alcoholic fatty liver disease (NAFLD), overweight, obesity, and metabolic syndrome (MS) were 24.8%, 41.5%, 27.1%, and 34.4%, respectively...
January 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28351888/depletion-in-lpa-i-a-ii-particles-enhances-hdl-mediated-endothelial-protection-in-familial-lcat-deficiency
#13
Monica Gomaraschi, Alice Ossoli, Samuela Castelnuovo, Sara Simonelli, Chiara Pavenello, Gloria Balzarotti, Marcello Arca, Alessia Di Costanzo, Tiziana Sampietro, Gaetano Vaudo, Damiano Baldassarre, Fabrizio Veglia, Guido Franceschini, Laura Calabresi
Aim of the study was to evaluate the vasoprotective effects of HDL isolated from carriers of LCAT deficiency, which are characterized by a selective depletion of LpA-I:A-II particles and predominance of prebeta migrating HDL. HDL were isolated from LCAT deficient carriers and tested in vitro for their capacity to promote NO production and to inhibit VCAM-1 expression in cultured endothelial cells. HDL from carriers were more effective than control HDL in promoting eNOS activation with a gene-dose dependent effect (PTrend=0...
March 28, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28342064/hdl-cholesterol-reappraisal-of-its-clinical-relevance
#14
REVIEW
Winfried März, Marcus E Kleber, Hubert Scharnagl, Timotheus Speer, Stephen Zewinger, Andreas Ritsch, Klaus G Parhofer, Arnold von Eckardstein, Ulf Landmesser, Ulrich Laufs
BACKGROUND: While several lines of evidence prove that elevated concentrations of low-density lipoproteins (LDL) causally contribute to the development of atherosclerosis and its clinical consequences, high-density lipoproteins are still widely believed to exert atheroprotective effects. Hence, HDL cholesterol (HDL-C) is in general still considered as "good cholesterol". Recent research, however, suggests that this might not always be the case and that a fundamental reassessment of the clinical significance of HDL-C is warranted...
March 24, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28340865/association-of-systemic-inflammation-adiposity-and-metabolic-dysregulation-with-asthma-burden-among-hispanic-adults
#15
Deepa Rastogi, Molly Jung, Garrett Strizich, Pamela A Shaw, Sonia M Davis, Oana L Klein, Frank J Penedo, Andrew L Ries, Martha L Daviglus, Juan J Moreiras, Matthias A Salathe, Juan C Celedón, Carmen R Isasi, Robert C Kaplan
RATIONALE: Obesity-related asthma is associated with higher disease burden than normal-weight asthma among Hispanics. Adiposity, metabolic dysregulation, and inflammation are all implicated in pathogenesis of obesity-related asthma, but their independent contributions are poorly understood. OBJECTIVE: To examine the independent contributions of body fat distribution, metabolic abnormalities and inflammation on asthma symptoms and pulmonary function among Hispanics...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28333301/preconception-maternal-lipoprotein-levels-in-relation-to-fecundability
#16
Sarah J Pugh, Enrique F Schisterman, Richard W Browne, Anne M Lynch, Sunni L Mumford, Neil J Perkins, Robert Silver, Lindsey Sjaarda, Joseph B Stanford, Jean Wactawski-Wende, Brian Wilcox, Katherine L Grantz
STUDY QUESTION: Are maternal preconception lipid levels associated with fecundability? SUMMARY ANSWER: Fecundability was reduced for all abnormal female lipid levels including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and total triglyceride levels. WHAT IS KNOWN ALREADY: Subfecundity affects 7-15% of the population and lipid disorders are hypothesized to play a role since cholesterol acts as a substrate for the synthesis of steroid hormones...
May 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28329157/low-normalized-grip-strength-is-a-biomarker-for-cardiometabolic-disease-and-physical-disabilities-among-u-s-and-chinese-adults
#17
Mark D Peterson, Kate Duchowny, Qinqin Meng, Yafeng Wang, Xinxin Chen, Yaohui Zhao
Background: Evidence highlights the importance of muscular strength as a protective factor for health and function across aging populations. The purpose of this study was to examine the extent to which low normalized grip strength (NGS) serves as a biomarker for both cardiometabolic disease and physical disability in U.S. and Chinese adults. Methods: Middle aged and older adults from the U.S. National Health and Nutrition Examination Survey 2011-2012 and 2013-2014 combined surveys (n = 4,544), and the 2011 wave of the China Health and Retirement Longitudinal Study (n = 6,030) were included...
March 10, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28327832/-frequency-of-metabolic-syndrome-in-residents-of-an-andean-region-in-peru
#18
Juana Aurelia Ninatanta-Ortiz, Luz Amparo Núñez-Zambrano, Segunda Aydeé García-Flores, Franco Romaní Romaní
Objectives.: To calculate the frequency of metabolic syndrome (MetS) and its associated characteristics in selected populations residing in the urban areas of two districts in the Cajamarca region. Materials and methods.: Cross-sectional study performed in 2014, obtaining randomized samples from three target study populations: high school students, university students, and schoolchildren mothers. In adults, MetS was defined by means of Third Adult Treatment Panel (ATP III) criteria, and in teenagers, the modified Cook criteria were used...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28323999/metabolically-healthy-obesity-and-ischemic-heart-disease-a-10-year-follow-up-of-the-inter99-study
#19
Louise Hansen, Marie K Netterstrøm, Nanna B Johansen, Pernille F Rønn, Dorte Vistisen, Lise Ln Husemoen, Marit E Jørgensen, Naja H Rod, Kristine Færch
Context: Recent studies have suggested that a subgroup of obese individuals is not at increased risk of obesity-related complications. This subgroup has been referred to as metabolically healthy obese. Objective: To investigate whether obesity is a risk factor for development of ischemic heart disease (IHD) irrespective of metabolic health. Design: 6,238 men and women from the Danish prospective Inter99 study were followed during 10.6 (SD 1...
March 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28317295/two-year-follow-up-of-patients-with-septic-shock-presenting-with-low-hdl-the-effect-upon-acute-kidney-injury-death-and-estimated-glomerular-filtration-rate
#20
K Roveran Genga, C Lo, M Cirstea, G Zhou, K R Walley, J A Russell, A Levin, J H Boyd
BACKGROUND: Sepsis is associated with decreased levels of high-density lipoprotein (HDL) cholesterol. HDL has anti-inflammatory properties, and the use of Apo A-I mimetic peptides is associated with renal function improvement in animal models of sepsis. However, it is not known whether decreased HDL level results in impaired renal function in human sepsis. We investigated whether low levels of HDL conferred an increased risk of sepsis-associated acute kidney injury (AKI) or long-term decreased estimated glomerular filtration rate (eGFR) after sepsis...
May 2017: Journal of Internal Medicine
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