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https://www.readbyqxmd.com/read/28545089/the-dynamic-behaviour-of-metabolic-syndrome-and-its-components-in-an-eight-year-population-based-cohort-from-the-mediterranean
#1
Maria A Barceló, Antonio Rodríguez-Poncelas, Marc Saez, Gabriel Coll-de-Tuero
BACKGROUND: The significant rise in the prevalence of obesity coincides with the considerable increase in the prevalence of metabolic syndrome (MS) currently being observed worldwide. The components of MS are not static and their dynamics, such as the order of their occurrence, or the time of exposure to them are, as yet, unknown but could well be clinically relevant. Our objective was to study the dynamic behaviour of MS and its components in a large population-based cohort from a Mediterranean region...
2017: PloS One
https://www.readbyqxmd.com/read/28534127/genetics-of-triglycerides-and-the-risk-of-atherosclerosis
#2
REVIEW
Jacqueline S Dron, Robert A Hegele
PURPOSE OF REVIEW: Plasma triglycerides are routinely measured with a lipid profile, and elevated plasma triglycerides are commonly encountered in the clinic. The confounded nature of this trait, which is correlated with numerous other metabolic perturbations, including depressed high-density lipoprotein cholesterol (HDL-C), has thwarted efforts to directly implicate triglycerides as causal in atherogenesis. Human genetic approaches involving large-scale populations and high-throughput genomic assessment under a Mendelian randomization framework have undertaken to sort out questions of causality...
July 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28523037/frequency-of-dyslipidemia-in-patients-with-lupus-nephritis
#3
Saba Sajjad, Sumaira Farman, Muhammad Ahmed Saeed, Nighat Mir Ahmad, Bilal Azeem Butt
OBJECTIVE: To determine the frequency of dyslipidemia in patients with lupus nephritis and its association with the degree of proteinuria. METHODS: This cross-sectional analytic study included 65 patients who fulfilled the ACR (American College of Rheumatology) criteria for SLE and had renal involvement, presenting to the Division of Rheumatology, Fatima Memorial Hospital (FMH), and Lahore from 21(st) Sep 2016 to 20(th) Dec 2016. After 12 hours overnight fast their blood samples were assessed for total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL)...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28506386/serum-triglyceride-high-density-lipoprotein-cholesterol-apolipoprotein-b-and-coronary-heart-disease-in-a-chinese-population-undergoing-coronary-angiography
#4
Yan Ling, Jingjing Jiang, Bingjie Wu, Xin Gao
BACKGROUND: Increased serum triglyceride and apolipoprotein B (apoB) levels and decreased high-density lipoprotein cholesterol (HDL-C) levels are risk factors for cardiovascular diseases. The major types of dyslipidemia in Chinese population are hypertriglyceridemia and low HDL-C. OBJECTIVE: This study aimed to evaluate the effect of HDL-C, triglyceride, and apoB levels on the risk of coronary heart disease (CHD) in a Chinese population undergoing coronary angiography...
May 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28505467/low-cholesterol-level-as-a-risk-marker-of-inpatient-and-post-discharge-violence-in-acute-psychiatry-a-prospective-study-with-a-focus-on-gender-differences
#5
Bjørn Magne S Eriksen, Stål Bjørkly, Øyvind Lockertsen, Ann Færden, John Olav Roaldset
Several studies indicate an association between low levels of serum cholesterol and aggressive behaviour, but prospective studies are scarce. In this naturalistic prospective inpatient and post-discharge study from an acute psychiatric ward, we investigated total cholesterol (TC) and high-density lipoprotein (HDL) as risk markers of violence. From March 21, 2012, to March 20, 2013, 158 men and 204 women were included. TC and HDL were measured at admission. Violence was recorded during hospital stay and for the first 3 months post-discharge...
May 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28502504/high-density-lipoproteins-and-adrenal-steroidogenesis-a-population-based-study
#6
Edward Buitenwerf, Michiel N Kerstens, Thera P Links, Ido P Kema, Robin P F Dullaart
BACKGROUND: Cholesterol trafficked within plasma lipoproteins, in particular high-density lipoproteins (HDL), may represent an important source of cholesterol that is required for adrenal steroidogenesis. Based on a urinary gas chromatography method, compromised adrenal function has been suggested in men but not in women with (genetically determined) low plasma HDL-cholesterol (HDL-C). OBJECTIVE: The objective of the article was to examine the extent to which glucocorticoid production relates to HDL-C in a population-based cohort...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28502489/dietary-carbohydrate-and-fat-intakes-are-differentially-associated-with-lipid-abnormalities-in-korean-adults
#7
SuJin Song, Won O Song, YoonJu Song
BACKGROUND: A high prevalence of metabolic syndrome along with increasing rates of low high-density lipoprotein cholesterol (HDL-C) and elevated triglycerides (TGs) is shown in Korean adults. Little is known about the associations between macronutrient intake and lipid abnormalities in the Asian population, whose major energy source is carbohydrates. OBJECTIVE: We examined the associations of dietary carbohydrate and fat intakes with lipid abnormalities in Korean adults...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28453105/-prevalence-of-metabolic-syndrome-in-pubertal-stages-of-female-students
#8
João Batista da Silva, Elza M de Melo, Maria Thereza Micussi, George Dantas de Azevedo, Telma M Lemos, Maria H Spyrides, Ricardo F Arrais, Técia M Maranhão
Objective To analyze the prevalence of metabolic syndrome (MS) in pubertal stages of female students. Methods Cross-sectional study of 449 school children between eight and 18 years, stratified by pubertal stage, body mass index (BMI) and body fat percentage (BF %). The MS was classified according to the International Diabetes Federation. The analysis by frequency distribution, confidence intervals (95 %), Chi-square and odds ratio for associations was performed. Results The prevalence of MS was 3.3 % (CI:2 %-5 %) and 2...
June 2016: Revista de Salud Pública
https://www.readbyqxmd.com/read/28451083/prevalence-of-cardio-metabolic-risk-factors-in-a-nationally-representative-sample-of-iranian-adolescents-the-caspian-iii-study
#9
Roya Kelishadi, Ramin Heshmat, Farshad Farzadfar, Mohammad Esmaeil Motlag, Maryam Bahreynian, Saeid Safiri, Gelayol Ardalan, Ehsan Rezaei Darzi, Hamid Asayesh, Fatemeh Rezaei, Mostafa Qorbani
Introduction: The aim of the present study is to explore the prevalence and mean of cardiometabolic risk factors and liver enzymes of Iranian adolescents living in regions with different socioeconomic status (SES). To the best of our knowledge this is the first study reporting these data at sub-national level in Iran. Methods: This multi-centric study was performed in 2009-2010 on a stratified multi-stage probability sample of 5940 students aged 10-18 years, living in urban and rural areas of 27 provinces of Iran...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28447439/lipid-abnormalities-in-type-2-diabetes-mellitus-patients-with-overt-nephropathy
#10
Sabitha Palazhy, Vijay Viswanathan
BACKGROUND: Diabetic nephropathy is a major complication of diabetes and an established risk factor for cardiovascular events. Lipid abnormalities occur in patients with diabetic nephropathy, which further increase their risk for cardiovascular events. We compared the degree of dyslipidemia among type 2 diabetes mellitus (T2DM) subjects with and without nephropathy and analyzed the factors associated with nephropathy among them. METHODS: In this retrospective study, T2DM patients with overt nephropathy were enrolled in the study group (n=89) and without nephropathy were enrolled in the control group (n=92)...
April 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28442233/the-chads2-and-cha2ds2-vasc-scores-predict-atrial-fibrillation-in-dyslipidemic-individuals-role-of-incorporating-low-high-density-lipoprotein-cholesterol-levels
#11
Fotios Barkas, Moses Elisaf, Panagiotis Korantzopoulos, Stavroula Tsiara, Evangelos Liberopoulos
AIM: To investigate the value of CHADS2 and CHA2DS2-VASc scores in predicting atrial fibrillation (AF) among dyslipidemic individuals and assess the additional value of incorporating low levels of high-density lipoprotein cholesterol (HDL-C). METHODS: This observational study included 1241 individuals attending a lipid clinic. Models including clinical and laboratory parameters were constructed to test the predictive value of CHADS2 and CHA2DS2-VASc scores as well as low HDL-C levels for incident AF...
April 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28441156/interpreting-lipoproteins-in-nonalcoholic-fatty-liver-disease
#12
Katriina Nemes, Fredrik Åberg
PURPOSE OF REVIEW: The pathophysiologies of nonalcoholic fatty liver disease (NAFLD), metabolic syndrome, and cardiovascular disease are closely interlinked and associated with atherogenic dyslipidemia. Liver and cardiovascular disease may silently progress to advanced stages if alarming signs, such as abdominal obesity, elevated fasting and postprandial triglycerides, and low HDL cholesterol are overlooked. We review the metabolic mechanisms in NAFLD at the cellular level in the context of standard clinical lipid measurements...
April 22, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28441155/do-triglyceride-lowering-drugs-decrease-risk-of-cardiovascular-disease
#13
Kevin C Maki, Mary R Dicklin
PURPOSE OF REVIEW: This review summarizes the evidence supporting a relationship between lowering triglycerides (TGs) and TG-rich lipoprotein cholesterol (TGRL-C) levels and reduced atherosclerotic cardiovascular disease (ASCVD) event risk. RECENT FINDINGS: Data from observational investigations, including studies of genetic variants, provide evidence consistent with a causal relationship between elevations in TG and TGRL-C and greater risk for ASCVD. Randomized controlled trial evidence of ASCVD risk reduction with therapies that substantially lower TG and TGRL-C is limited by the fact that no large-scale trial results have been published from a study that enrolled subjects selected specifically on the basis of TG or TGRL-C elevation, although three such trials are underway or in the planning stages...
April 22, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#14
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28428072/membrane-lipid-alterations-in-the-metabolic-syndrome-and-the-role-of-dietary-oils
#15
REVIEW
Javier S Perona
The metabolic syndrome is a cluster of pathological conditions, including hypertension, hyperglycemia, hypertriglyceridemia, obesity and low HDL levels that is of great concern worldwide, as individuals with metabolic syndrome have an increased risk of type-2 diabetes and cardiovascular disease. Insulin resistance, the key feature of the metabolic syndrome, might be at the same time cause and consequence of impaired lipid composition in plasma membranes of insulin-sensitive tissues like liver, muscle and adipose tissue...
April 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28423036/metabolic-syndrome-serum-uric-acid-and-renal-risk-in-patients-with-t2d
#16
Francesca Viazzi, Pamela Piscitelli, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina Russo, Pietro Guida, Paola Fioretto, Salvatore De Cosmo, Roberto Pontremoli
BACKGROUND AND AIMS: Metabolic Syndrome (Mets) and increased serum uric acid (SUA), are well known renal risk predictors and often coexist in patients with type 2 diabetes (T2D). Whether they independently contribute to the onset of CKD is at present unclear. METHODS AND RESULTS: Within the AMD Annals database we identified patients with T2D and normal renal function and urine albumin excretion at baseline and regular follow-up visits during a 4-year period. Blood pressure, BMI, HDL, triglycerides, and SUA were available in 14,267 patients...
2017: PloS One
https://www.readbyqxmd.com/read/28421790/abdominal-obesity-is-strongly-associated-to-blood-pressure-in-young-mexicans
#17
Rene Urquidez Romero, Miguel Murguía Romero, Julián Esparza Romero, Beatriz Araceli Díaz Torres, Alejandra Rodríguez Tadeo, Gabriel Medrano Donlucas, Arnulfo Ramos Jiménez, Abraham Wall Medrano, Itzell A Gallardo Ortíz, Diana C Tapia-Pancardo C Tapia Pancardo, A René Méndez Cruz, J Rafael Jiménez Flores, Rafael Villalobos Molina
OBJECTIVE: The objective of this study was to determine associations between abdominal obesity (AOb) and the other components of metabolic syndrome (MetS) in young Mexicans in a cross-sectional survey completed during a 4 year period. METHODS: This cross-sectional study reports on components and prevalence of MetS by using Alberti et al. (16) criteria, as well as association between AOb and elevated blood pressure (BP) of 2,993 Mexican university students, ages 17 to 25 years (66% women) from central and northern Mexico, over a 4-year survey (2010-2013)...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28414931/human-adipose-tissue-levels-of-persistent-organic-pollutants-and-metabolic-syndrome-components-combining-a-cross-sectional-with-a-10-year-longitudinal-study-using-a-multi-pollutant-approach
#18
Vicente Mustieles, Mariana F Fernández, Piedad Martin-Olmedo, Beatriz González-Alzaga, Andrés Fontalba-Navas, Russ Hauser, Nicolás Olea, Juan P Arrebola
We aimed to assess the influence of long-term exposure to POPs on the risk of metabolic syndrome, combining a cross-sectional with a 10-year longitudinal follow-up design. Residues of eight POPs were quantified in adipose tissue samples from 387 participants recruited between 2003 and 2004 in Granada province (Spain). The outcome ("metabolically compromised") was defined as having ≥1 diagnosis of type 2 diabetes, hypertension, hypertriglyceridemia, and/or low HDL cholesterol. The cross-sectional analysis was conducted in the initial cohort, while the 10-year longitudinal analysis was conducted in those 154 participants free of any of the so-mentioned metabolic diseases and classified as "metabolically healthy" at recruitment...
April 14, 2017: Environment International
https://www.readbyqxmd.com/read/28410864/-prevalence-of-cardiovascular-risk-factors-in-urban-and-rural-communities-in-the-wilaya-of-tlemcen-algeria-a-comparative-study
#19
L Boukli Hacène, M-A Khelil, D Chabane Sari, K Meguenni, A Meziane Tani
BACKGROUND: In Algeria, few studies have been conducted to determine the prevalence of genetic and environmental risk factors of cardiovascular diseases as a function of residence. The objective of this study was therefore to determine the prevalence of cardiovascular risk factors according to sex and age in urban and rural communities in the Wilaya of Tlemcen (Algeria). MATERIAL AND METHODS: A population survey was conducted on a representative sample of 864 individuals aged 20years and over, among inhabitants in urban and rural communes in the Wilaya of Tlemcen...
April 11, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28399925/human-serum-rnase-l-level-is-inversely-associated-with-metabolic-syndrome-and-age
#20
Yi-Ting Wang, Ping-Huei Tseng, Chi-Ling Chen, Der-Sheng Han, Yu-Chiao Chi, Fen-Yu Tseng, Wei-Shiung Yang
BACKGROUND: Ribonuclease-L (RNase-L) was known to be a ubiquitous enzyme involved in several cellular functions, especially innate immunity. It was recently shown to participate in adipogenesis in rodents. Here, we developed a method to measure serum levels of RNase-L and analyzed the relationship between RNase-L and metabolic syndrome (MetS). METHODS: A total of 396 subjects were recruited from a health check-up program. An in-house RNase-L immunoassay was developed...
April 11, 2017: Cardiovascular Diabetology
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