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https://www.readbyqxmd.com/read/27904507/impact-of-variants-in-cetp-and-apo-ai-genes-on-serum-hdl-cholesterol-levels-in-men-and-women-from-the-polish-population
#1
Marta Włodarczyk, Małgorzata Wrzosek, Grażyna Nowicka, Beata Jabłonowska-Lietz
INTRODUCTION: Polymorphisms in the cholesterol ester transfer protein (CETP) gene and apolipoprotein AI (apo AI) gene are identified as the most common genetic factors influencing high-density lipoprotein cholesterol (HDL cholesterol) levels. Low HDL cholesterol is an important risk factor for cardiovascular disease. We investigated the effect of the TaqIB polymorphism of the CETP gene and the 75G/A polymorphism of the apo AI gene on the HDL cholesterol concentration in a sample of Polish adults...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27898410/cadmium-exposure-is-associated-with-the-prevalence-of-dyslipidemia
#2
Zhou Zhou, Yong-Hui Lu, Hui-Feng Pi, Peng Gao, Min Li, Lei Zhang, Li-Ping Pei, Xiang Mei, Lin Liu, Qi Zhao, Qi-Zhong Qin, Yu Chen, Yue-Ming Jiang, Zhao-Hui Zhang, Zheng-Ping Yu
BACKGROUND: Cadmium is a widespread environmental and occupational pollutant that accumulates in human body with a biological half-life exceeding 10 years. Cadmium exposure has been demonstrated to increase rates of cardiovascular diseases. Whether occupational cadmium exposure is associated with the increase in the prevalence of dyslipidemia and hence contributes to the risk of cardiovascular diseases is still equivocal. To test the hypothesis that exposure to cadmium is related to the prevalence of dyslipidemia, we examined the associations between blood cadmium concentration and the prevalence of dyslipidemia in workers occupationally exposed to cadmium in China...
November 30, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27898293/metabolic-syndrome-among-adults-in-china-the-2010-china-noncommunicable-disease-surveillance
#3
Jieli Lu, Limin Wang, Mian Li, Yu Xu, Yong Jiang, Weiqing Wang, Jianhong Li, Shengquan Mi, Mei Zhang, Yichong Li, Tiange Wang, Min Xu, Zhiyun Zhao, Meng Dai, Shenghan Lai, Wenhua Zhao, Linhong Wang, Yufang Bi, Guang Ning
CONTEXT: In China, data on the prevalence of metabolic syndrome have been rare recently. OBJECTIVE: The objective of the study was to evaluate the prevalence of metabolic syndrome and its components in 2010. DESIGN, SETTING AND PARTICIPANTS: The study covered all 31 provinces of mainland China and consisted of a nationally representative population sample of 98,658 Chinese adults aged ≥ 18 years. Of these, 97,098 participants were eligible for the data analysis reported here...
November 29, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27890975/prevalence-of-type-2-diabetes-mellitus-among-urban-sikh-population-of-amritsar
#4
Amrinder Singh, Shweta Shenoy, Jaspal Singh Sandhu
CONTEXT: Type 2 Diabetes Mellitus (T2DM) refers to a group of common metabolic disorders that share the phenotype of Hyperglycemia. More than 60% of the world's population with diabetes comes from Asia. AIM: To study the prevalence of Type 2 Diabetes Mellitus among Sikh individuals living in the urban localities of Amritsar. SETTINGS AND DESIGN: The study was designed in the Faculty of Sports Medicine & Physiotherapy, Guru Nanak Dev University, Amritsar, Punjab, India...
October 2016: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/27872832/prevalence-of-risk-factors-for-cardiovascular-and-kidney-disease-in-brazilian-healthy-preschool-children
#5
Adriana Cândida da Silva, Marcelo de Sousa Tavares, Maria Goretti Moreira Guimarães Penido
AIM: To investigate the prevalence of nutritional parameters of risk for cardiovascular disease (CVD) and kidney diseases in healthy preschool children. METHODS: This is an observational cross-sectional study with 60 healthy children, of both genders, aged two to six years old and 56 mothers, in Belo Horizonte, Minas Gerais, Brazil. Preschool children and their families with regular activities at public schools were invited to paticipate in the study. The following characteristics were assessed: Socio-demographic condictions, clinical health, anthropometric, biochemical, lifestyle and data on food consumption...
November 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27872574/prevalence-and-pattern-of-dyslipidemia-in-hyperglycemic-patients-and-its-associated-factors-among-pakistani-population
#6
Maliha Sarfraz, Sanaullah Sajid, Muhammad Aqeel Ashraf
In diabetes mellitus dyslipidemia is one of the major risk factors for cardiovascular disease. In type 2 diabetes mellitus early detection and treatment of dyslipidemia can avoid risk for cardiovascular disorder. The present study was carried to determine the prevalence and pattern of hyperlipidemia in patients with hyperglycemia. The cross sectional study was done in different laboratories of Pakistan, the laboratories served patients referred from different government and private hospitals between July 2014 and June 2015...
November 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27868450/pharmacological-management-of-diabetic-dyslipidemia
#7
T D Filippatos, M Florentin, M Georgoula, M S Elisaf
Diabetes mellitus is associated with increased cardiovascular disease (CVD) risk. Areas covered: Main goal of hypolipidemic treatment in diabetic patients is low-density lipoprotein cholesterol (LDL-C) lowering with the use of statins. Addition of ezetimibe is useful in diabetic patients who cannot achieve their LDL-C target. However, many diabetic patients have increased residual CVD risk, which is mainly attributed to high triglycerides and low high-density lipoprotein (HDL-C) values. The addition of fenofibrate targets these variables and possibly reduces residual CVD risk, but a possible beneficial effect has been shown only in a pre-specified subgroup analysis in patients with high triglycerides and low HDL-C values...
December 2, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27866837/high-density-lipoproteins-exert-pro-inflammatory-effects-on-macrophages-via-passive-cholesterol-depletion-and-pkc-nf-%C3%AE%C2%BAb-stat1-irf1-signaling
#8
Emiel P C van der Vorst, Kosta Theodorou, Yongzheng Wu, Marten A Hoeksema, Pieter Goossens, Christina A Bursill, Taghi Aliyev, Leonie F A Huitema, Sander W Tas, Ine M J Wolfs, Marijke J E Kuijpers, Marion J Gijbels, Casper G Schalkwijk, Debby P Y Koonen, Shahla Abdollahi-Roodsaz, Kimberly McDaniels, Chih-Chieh Wang, Michael Leitges, Toby Lawrence, Jogchum Plat, Miranda Van Eck, Kerry-Anne Rye, Lhousseine Touqui, Menno P J de Winther, Erik A L Biessen, Marjo M P C Donners
Membrane cholesterol modulates a variety of cell signaling pathways and functions. While cholesterol depletion by high-density lipoproteins (HDLs) has potent anti-inflammatory effects in various cell types, its effects on inflammatory responses in macrophages remain elusive. Here we show overt pro-inflammatory effects of HDL-mediated passive cholesterol depletion and lipid raft disruption in murine and human primary macrophages in vitro. These pro-inflammatory effects were confirmed in vivo in peritoneal macrophages from apoA-I transgenic mice, which have elevated HDL levels...
November 16, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27864237/effect-of-selected-clinical-trial-publication-on-adjunctive-nonstatin-medication-prescribing-in-the-veterans-health-administration-system
#9
Krystal S Titus-Rains, Matthew A Cantrell, Jason A Egge, Bruce Alexander, Robert F Shaw, Tami R Argo
PURPOSE: The question of whether publication of selected clinical trials is temporally followed by changes in prescribing of adjunctive lipid-lowering medications was evaluated. METHODS: In this retrospective preanalysis and postanalysis, Veterans Health Administration (VHA) patients 18 years or older who received a new or renewed order for any lipid-lowering medication between April 2, 2004, and September 2, 2014, were included. This period was chosen based on the publication dates of three trials investigating the efficacy of nonstatin medications: Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia (ENHANCE, April 3, 2008), Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus (ACCORD Lipid, March 14, 2010), and Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy (AIM-HIGH, December 15, 2011)...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27863493/impact-of-low-high-density-lipoprotein-cholesterol-level-on-2-year-clinical-outcomes-after-acute-myocardial-infarction-in-patients-with-diabetes-mellitus
#10
Hyung Joon Joo, Sang-A Cho, Soon Jun Hong, Seung-Ho Hur, Jang-Ho Bae, Dong-Ju Choi, Young-Keun Ahn, Jong-Seon Park, Rak-Kyeong Choi, Donghoon Choi, Joon-Hong Kim, Kyoo-Rok Han, Hun-Sik Park, So-Yeon Choi, Jung-Han Yoon, Hyeon-Cheol Kwon, Seung-Woon Rha, Kyung-Kuk Hwang, Kyung-Tae Jung, Seok-Kyu Oh, Jae-Hwan Lee, Eun-Seok Shin, Kee-Sik Kim, Hyo-Soo Kim, Do-Sun Lim
BACKGROUND: It is still unclear whether low high-density lipoprotein cholesterol (HDL-C) affects cardiovascular outcomes after acute myocardial infarction (AMI), especially in patients with diabetes mellitus. METHODS: A total of 984 AMI patients with diabetes mellitus from the DIabetic Acute Myocardial InfarctiON Disease (DIAMOND) Korean multicenter registry were divided into two groups based on HDL-C level on admission: normal HDL-C group (HDL-C ≥ 40 mg/dL, n = 519) and low HDL-C group (HDL-C < 40 mg/dL, n = 465)...
November 18, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27846925/consumption-of-energy-dense-diets-in-relation-to-metabolic-syndrome-and-inflammatory-markers-in-iranian-female-nurses
#11
Leila Azadbakht, Fahimeh Haghighatdoost, Ammar Hassanzadeh Keshteli, Bagher Larijani, Ahmad Esmaillzadeh
OBJECTIVE: To examine the relationship between dietary energy density (DED) and risk of metabolic syndrome (MetS), its components and inflammatory markers. DESIGN: Cross-sectional study. Dietary intakes were assessed using a validated dish-based semi-quantitative FFQ. DED was calculated by dividing energy intake (kcal/d) by the total weight of foods only (g/d). MetS was defined based on the National Cholesterol Education Program Adult Treatment Panel III criteria...
November 16, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27844137/-clinical-importance-of-hdl-cholesterol
#12
REVIEW
W März, M E Kleber, H Scharnagl, T Speer, S Zewinger, A Ritsch, K G Parhofer, A von Eckardstein, U Landmesser, U Laufs
BACKROUND: Each year 16-17 million determinations of high-density lipoprotein cholesterol (HDL-C) are conducted and interpreted in Germany. Recently acquired data have led to a fundamental reassessment of the clinical significance of HDL-C. METHOD: This review article is based on a selective literature search. RESULTS: Low HDL‑C levels usually indicate an increased cardiovascular risk, particularly in primary prevention but the epidemiological relationship between HDL‑C and the risk is complex...
November 14, 2016: Herz
https://www.readbyqxmd.com/read/27829526/sex-specific-incidence-rates-and-risk-factors-of-premature-cardiovascular-disease-a-long-term-follow-up-of-the-tehran-lipid-and-glucose-study
#13
Ali Eslami, Amirhossein Mozaffary, Arash Derakhshan, Fereidoun Azizi, Davood Khalili, Farzad Hadaegh
OBJECTIVES: To investigate the risk factors for premature cardiovascular disease (CVD) and to quantify their population attributable fractions (PAFs) among an Iranian population during a median follow-up of 12years. METHODS: A total of 2235 men and 3703 women, aged ≥30years, free of CVD at baseline were entered into the study. Premature CVD was defined as having a history of CVD events before the age of 55 and 65 for men and women, respectively. Multivariate Cox proportional hazard regression models were used to determine the risk factors associated with premature CVD events...
October 17, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27827461/association-and-interaction-of-apoa5-bud13-cetp-lipa-and-health-related-behavior-with-metabolic-syndrome-in-a-taiwanese-population
#14
Eugene Lin, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao, Shih-Jen Tsai
Increased risk of developing metabolic syndrome (MetS) has been associated with the APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 genes. In this replication study, we reassessed whether these genes are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population. We also analyzed the interactions between environmental factors and these genes in influencing MetS and its individual components. A total of 3,000 Taiwanese subjects were assessed in this study...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822124/changes-in-coronary-heart-disease-risk-profiles-of-hiv-patients-in-zimbabwe-over-9-months-a-follow-up-study
#15
Danai Tavonga Zhou, Olav Oektedalen, Sandra Shawarira-Bote, Babill Stray-Pedersen
Dyslipidemia, hypertension, inflammation, and coronary heart disease (CHD) are adverse events in human immunodeficiency virus (HIV)-infected patients even if they are receiving antiretroviral therapy (ART). Yet, data on CHD risk induced by HIV or ART in sub-Saharan Africa are limited. The aim of this longitudinal study was to describe changes in CHD risk profiles measured by lipids, inflammatory markers, and Framingham scores among HIV-positive patients previously reported from Harare, Zimbabwe. Patients were grouped into ART-experienced patients (n=147) and ART-naïve patients (n=23) and followed up for 9 months...
2016: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/27821989/metabolic-syndrome-can-we-keep-check
#16
Abha Singh, Neha Sinha
BACKGROUND: Metabolic syndrome (MetS) is on the rise due to the epidemic increase of obesity. It increases the risk of atherosclerotic cardiovascular diseases and type II diabetes mellitus. AIMS: To study the prevalence of MetS and its components in premenopausal and postmenopausal women. DESIGN: Cross-sectional comparative study. MATERIAL AND METHOD: Five hundred premenopausal women and 500 postmenopausal women in the age group 40-65 years, attending OPD of Obstetrics and Gynecology Department of Pt...
December 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27812606/association-of-the-conicity-index-with-diabetes-and-hypertension-in-brazilian-women
#17
Mirelli Dantas Andrade, Maria Camila Pruper de Freitas, Alyne Mayumi Sakumoto, Caroline Pappiani, Samantha Caesar de Andrade, Viviane Laudelino Vieira, Nágila Raquel Teixeira Damasceno
Objective: The goal of this study was evaluate the conicity index (C index) in women and its association with hypertension (SAH) and diabetes mellitus (DM). Subjects and methods: This was a cross-sectional study, with 573 women between 20 and 59 years of age. After analysis of clinical and demographic characteristics, anthropometric variables were measured and used to calculate the C index. Plasma glucose and lipid profile were evaluated by standard methods. The analysis of the results was based on logistic regression and the odds ratio (OR) was calculated, which was used to assess the association of the variable outcome with the variable exposure using two logistic regression models that tested the possible influence of the C index in the chance of developing SAH or DM...
October 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27811453/insulin-resistance-metabolic-syndrome-and-lipids-in-african-women
#18
E E Young, C N Okafor, M O Iroezindu, I S Agbalu
BACKGROUND: The metabolic syndrome is closely related to insulin resistance (IR) and cardiovascular disease. This study examined the prevalence of IR and metabolic syndrome as well as factors associated with IR among Nigerian women. MATERIALS AND METHODS: Eighty-six women living in an urban area in Enugu, South-East Nigeria, were assessed. Demographic information included age, residence, physical activity, alcohol and tobacco intake and were collected with questionnaires...
November 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27810177/associations-between-sleep-duration-and-abnormal-serum-lipid-levels-data-from-the-korean-national-health-and-nutrition-examination-survey-knhanes
#19
Hee-Young Shin, Gaeun Kang, Sung-Wan Kim, Jae-Min Kim, Jin-Sang Yoon, Il-Seon Shin
BACKGROUND: Shorter or longer sleep duration has been reported to be associated with abnormal serum lipid levels, but the findings have been inconsistent. This study examined associations between sleep duration and abnormal serum lipid levels in a Korean adult population. METHODS: This study used the data of 13,609 people aged ≥20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) in 2010-2012. Sleep duration was classified into five groups: ≤5, 6, 7 (reference category), 8, and ≥9 hours...
August 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27798489/the-future-of-n-3-polyunsaturated-fatty-acid-therapy
#20
Michael H Davidson, Lane B Benes
PURPOSE OF REVIEW: This article focuses on the potential role by which a complex mixture of omega-3 fatty acids (OM3-FAs) may beneficially modify cardiovascular risk by modifying the cholesterol composition of atherogenic lipoproteins. This hypothesis is being tested in the STRENGTH trial, which is enrolling 13 000 patients on statins at high cardiovascular risk with hypertriglyceridemia and low HDL cholesterol (HDL-C) treated with an OM3-carboxylic acid. RECENT FINDINGS: Complex mixtures of OM3-FAs containing predominately eicosapentanoic acid and docosahexanoic acid in combination with statins lowers non-HDL by reducing triglyceride-rich lipoprotein cholesterol (TRL-C) while shifting small LDL cholesterol (LDL-C) to large LDL-C...
December 2016: Current Opinion in Lipidology
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