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https://www.readbyqxmd.com/read/29772479/adverse-lipid-profile-elevates-risk-for-subarachnoid-hemorrhage-a-prospective-population-based-cohort-study
#1
Joni Lindbohm, Miikka Korja, Pekka Jousilahti, Veikko Salomaa, Jaakko Kaprio
BACKGROUND AND AIMS: Studies report that both high and low total cholesterol (TC) elevates SAH risk. There are few prospective studies on high-density lipoproteins (HDL-C) and low-density lipoproteins (LDL-C), and apparently none concerns apolipoproteins A and B. We aimed to clarify the association between lipid profile and SAH risk. METHODS: The National FINRISK study provided risk-factor data recorded at enrolment between 1972 and 2007. During 1.52 million person-years of follow-up until 2014, 543 individuals suffered from incident hospitalized SAH or outside-hospital-fatal SAH...
May 5, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29764627/dietary-factors-influence-the-association-of-cyclin-d2-polymorphism-rs11063069-with-the-risk-of-metabolic-syndrome
#2
Gelareh Koochakpoor, Parvin Mirmiran, Maryam S Daneshpour, Firoozeh Hosseini-Esfahani, Bahareh Sedaghati-Khayat, Seyed Ahmad Hosseini, Fereidoun Azizi
The relationship of CCND2 gene variation, rs11063069 with metabolic syndrome (MetS) modulates by dietary factors but enough data are not available on this issue. So, the hypothesis, which assumes that dietary factors modulate the relationship of CCND2 polymorphisms with the risk of MetS was investigated in our study. Subjects of this nested case-control study were selected from participants of the Tehran Lipid and Glucose Study. Each case (n=974) was pair-matched individually with a control by age, sex and the follow-up duration...
April 2018: Nutrition Research
https://www.readbyqxmd.com/read/29758349/habitual-aerobic-exercise-gene-apoa5-named-rs662799-snp-and-response-of-blood-lipid-and-lipoprotein-phenotypes-among-older-chinese-adult
#3
Xiangyun Liu, Guoyuan Huang, Zhanbin Niu, Yuqin Wei, Ru Wang
BACKGROUND: The genetic component of dyslipidemia has been studied in adults but little in older population. It is remains unknown regarding influence and interaction of APOA5 gene single nucleotide polymorphism (SNP) and habitual aerobic exercise (HAE) on changes of blood lipids and lipoprotein phenotypes in older Chinese adults. METHODS: Four-hundred-twenty-three old Chinese individuals with HAE were divided into hyperlipidemia and normal groups. We genotyped polymorphic loci using matrix assisted laser desorption ionization time of flight mass spectrometry detection technology (MALDI-TOF)...
May 11, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29748333/hepatic-overexpression-of-endothelial-lipase-lowers-hdl-high-density-lipoprotein-but-maintains-reverse-cholesterol-transport-in-mice-role-of-sr-bi-scavenger-receptor-class-b-type-i-abca1-atp-binding-cassette-transporter-a1-dependent-pathways
#4
Shunichi Takiguchi, Makoto Ayaori, Emi Yakushiji, Takafumi Nishida, Kazuhiro Nakaya, Makoto Sasaki, Maki Iizuka, Harumi Uto-Kondo, Yoshio Terao, Makiko Yogo, Tomohiro Komatsu, Masatsune Ogura, Katsunori Ikewaki
OBJECTIVE: Reverse cholesterol transport (RCT) is a major mechanism by which HDL (high-density lipoprotein) protects against atherosclerosis. Endothelial lipase (EL) reportedly reduces HDL levels, which, in theory, would increase atherosclerosis. However, it remains unclear whether EL affects RCT in vivo. APPROACH AND RESULTS: Adenoviral vectors expressing EL or luciferase were intravenously injected into mice, and a macrophage RCT assay was performed. As expected, hepatic EL overexpression markedly reduced HDL levels...
May 10, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29744861/low-serum-cholesterol-levels-predict-inferior-prognosis-and-improve-nccn-ipi-scoring-in-diffuse-large-b-cell-lymphoma
#5
Rui Gao, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Wei Wu, Lei Cao, Lei Fan, Jian-Yong Li, Tao Yang, Wei Xu
Low circulating cholesterol concentration is associated with elevated cancer incidence and mortality. However, the association between cholesterol levels and diffuse large B cell lymphoma (DLBCL) remains unknown. The aim of our study was to evaluate the prognostic value of serum lipid profile in DLBCL. Five hundred and fifty enrolled subjects with detailed serum lipid levels at diagnosis of DLBCL were randomly divided into a training set (n=367) and a validation set (n=183) (ratio, 2:1). Multivariate Cox regression analyses screened the prognostic factors associated with progression-free survival (PFS) and overall survival (OS)...
May 9, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29742131/prevalence-of-high-bloodpressure-hyperglycemia-dyslipidemia-metabolic-syndrome-and-their-determinants-in-ethiopia-evidences-from-the-national-ncds-steps-survey-2015
#6
Yeweyenhareg Feleke Gebreyes, Dejuma Yadeta Goshu, Tedla Kebede Geletew, Terefe Gelibo Argefa, Theodros Getachew Zemedu, Kassahun Amenu Lemu, Feyissa Challa Waka, Alemayehu Bekele Mengesha, Fasil Shiferaw Degefu, Atkure Defar Deghebo, Habtamu Teklie Wubie, Mussie Gebremichael Negeri, Tefera Tadele Tesema, Yabetse Girma Tessema, Mulugeta Guta Regassa, Geremew Gonfa Eba, Misrak Getnet Beyene, Kissi Mudie Yesu, Girum Taye Zeleke, Yewondwossen Tadesse Mengistu, Abebe Bekele Belayneh
The prevalence of diabetes, dyslipidemias, and high blood pressure is increasing worldwide especially in low and middle income countries. World Health Organization has emphasized the importance of the assessment of the magnitude of the specific disease in each country. We determined the prevalence and determinant factors of high blood pressure, hyperglycemia, dyslipidemias and metabolic syndrome in Ethiopia. A community based survey was conducted from -April to June 2015 using WHO NCD STEPS instrument version 3...
2018: PloS One
https://www.readbyqxmd.com/read/29742114/the-magnitude-of-obesity-and-metabolic-syndrome-among-diabetic-chronic-kidney-disease-population-a-nationwide-study
#7
Piyawan Kittiskulnam, Nintita Sripaiboonkij Thokanit, Pisut Katavetin, Paweena Susanthitaphong, Nattachai Srisawat, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong
BACKGROUND: Although the prevalence of obesity and metabolic syndrome (MetS) among dialysis patients has been exceeding than general population, little is known regarding obesity and MetS in non-dialysis chronic kidney disease (CKD). We aimed to find the magnitude of obesity and MetS and their associations with impaired renal function among type 2 diabetes mellitus (T2DM) patients. METHODS: A national survey of T2DM patients was collected in the Thai National Health Security Office database during 2014-5...
2018: PloS One
https://www.readbyqxmd.com/read/29740686/circulating-survivin-levels-in-obstructive-sleep-apnoea
#8
Laszlo Kunos, Peter Horvath, Adrian Kis, David Laszlo Tarnoki, Adam Domonkos Tarnoki, Zsofia Lazar, Andras Bikov
INTRODUCTION: Obstructive sleep apnoea (OSA) is characterised by a low-grade systemic and airway inflammation; however, the regulatory mechanisms of inflammation are poorly explored. Survivin (Birc5) is an anti-apoptotic protein which inhibits Type 1 inflammation; however, this molecule has not been investigated in OSA. METHODS: Forty-five patients with OSA and 31 non-OSA control subjects were involved. Venous blood was collected for plasma survivin measurements before and after diagnostic overnight polysomnography...
May 8, 2018: Lung
https://www.readbyqxmd.com/read/29733304/an-experimental-model-of-diet-induced-metabolic-syndrome-in-rabbit-methodological-considerations-development-and-assessment
#9
Óscar Julián Arias-Mutis, Patricia Genovés, Conrado J Calvo, Ana Díaz, Germán Parra, Luis Such-Miquel, Luis Such, Antonio Alberola, Francisco Javier Chorro, Manuel Zarzoso
In recent years, obesity and metabolic syndrome (MetS) have become a growing problem for public health and clinical practice, given their increased prevalence due to the rise of sedentary lifestyles and unhealthy eating habits. Thanks to animal models, basic research can investigate the mechanisms underlying pathological processes such as MetS. Here, we describe the methods used to develop an experimental rabbit model of diet-induced MetS and its assessment. After a period of acclimation, animals are fed a high-fat (10% hydrogenated coconut oil and 5% lard), high-sucrose (15% sucrose dissolved in water) diet for 28 weeks...
April 20, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29729052/cardiovascular-risk-factors-in-adolescents-with-prediabetes
#10
S S Casagrande, A Menke, B Linder, S K Osganian, C C Cowie
AIMS: Adolescents with Type 2 diabetes are more likely to have cardiovascular disease (CVD) risk factors but there are few data available among adolescents with prediabetes. We characterized CVD risk factors among adolescents with prediabetes in the USA and compared levels of those risk factors with adolescents with normal glucose. METHODS: The 2005-2014 National Health and Nutrition Examination Survey, a nationally representative cross-sectional survey, included 2843 adolescents aged 12-19 years after excluding those with diabetes...
May 5, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29725169/the-role-of-ejection-fraction-to-clinical-outcome-of-acute-ischemic-stroke-patients
#11
Fidha Rahmayani, Paryono, Ismail Setyopranoto
Aims: The aim of the study was to determine the effect of left ventricular ejection fraction on clinical outcomes of acute ischemic stroke patients. Study Design: This study design was a prospective cohort observational study. Place and Duration of Study: This study was conducted at Stroke Unit, Neurology Ward, and Cardiology Ward at the Dr. Sardjito Hospital, Yogyakarta, Indonesia, between July and December 2016. Materials and Methods: Hospitalized acute ischemic stroke patients were recruited, with sample was taken by consecutive sampling until reaching amount fulfilling inclusion criterion was 62 persons...
April 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29717208/high-prevalence-of-diabetes-among-migrants-in-the-united-arab-emirates-using-a-cross-sectional-survey
#12
Nabil Sulaiman, Salah Albadawi, Salah Abusnana, Maisoon Mairghani, Amal Hussein, Fatheya Al Awadi, Abdulrazak Madani, Paul Zimmet, Jonathan Shaw
In 2011, the United Arab Emirates (UAE) had the 10th highest diabetes prevalence globally, but this was based on data that excluded migrants who comprise 80% of the population. This study assessed diabetes prevalence across the UAE population. A random sample of migrants was recruited from the visa renewal centers. Data were collected using interviews, anthropometric measurements and fasting blood for glucose, lipids and genetic analyses. 2724 adults completed the questionnaires and blood tests. Of these, 81% were males, 65% were ≤40 years old and 3% were above 60 years...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29716519/association-between-anthropometric-measures-and-cardiovascular-disease-cvd-risk-factors-in-hainan-centenarians-investigation-based-on-the-centenarian-s-health-study
#13
Qiao Zhu, Xiao-Bing Wang, Yao Yao, Chao-Xue Ning, Xiao-Ping Chen, Fu-Xin Luan, Ya-Li Zhao
BACKGROUND: Centenarians refer to a special group who have outlived most of their fellows. Body shape and abdominal obesity have been identified as cardiovascular disease (CVD) risk factors. Our study aimed to evaluate the relationship between body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) and CVD risk factors among male and female centenarians in Hainan province. METHODS: Five hundred thirty-seven centenarians aged between 100 and 115 (Mage = 107 years old) years participated in this study...
May 2, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29705571/association-of-a-cholesteryl-ester-transfer-protein-variant-rs1800777-with-fat-mass-hdl-cholesterol-levels-and-metabolic-syndrome
#14
Daniel de Luis, Olatz Izaola, David Primo, Emilia Gomez, Juan Jose Lopez, Ana Ortola, Rocio Aller
BACKGROUND: There is little evidence of the association between CETP SNPs and obesity and/or related metabolic parameters. OBJECTIVE: To analyze the association of the polymorphism rs1800777 of the CETP gene with anthropometric parameters, lipid profile, metabolic syndrome and its components, and adipokine levels in obese subjects without type 2 diabetes mellitus or hypertension. DESIGN: A population of 1005 obese subjects was analyzed. Electrical bioimpedance was performed, and blood pressure, presence of metabolic syndrome, dietary intake, physical activity, and biochemical tests were recorded...
April 25, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29699816/weight-gain-prevention-buffers-the-impact-of-cetp-rs3764261-on-high-density-lipoprotein-cholesterol-in-young-adulthood-the-study-of-novel-approaches-to-weight-gain-prevention-snap
#15
J M McCaffery, J M Ordovas, G S Huggins, C-Q Lai, M A Espeland, D F Tate, R R Wing
BACKGROUND AND AIMS: Two weight gain prevention strategies, one targeting small changes to diet and physical activity and a second targeting large changes, significantly reduced weight gain in young adulthood. We examined whether weight gain prevention blunts genetic risk for body weight increase and/or high density lipoprotein cholesterol (HDL-C) lowering over two years. METHODS AND RESULTS: Participants were 524 male and female young adults (mean age = 28.2, SD = 4...
March 6, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29695256/metabolic-distress-in-lipid-one-carbon-metabolic-pathway-through-low-vitamin-b-12-a-population-based-study-from-north-india
#16
Kallur Nava Saraswathy, Shipra Joshi, Suniti Yadav, Priyanka Rani Garg
BACKGROUND: Dyslipidemia and hyper-homocysteinemia are the major independent risk factors of cardio vascular disease. Deficiency of folate and vitamin B-12 are associated with both hyper-homocysteinemia and dyslipidemia. The aim of the study is to evaluate the relationship of homocysteine and its associated dietary determinant levels (Folate and Vitamin B-12) with lipids and obesity parameters (WC, BMI, WHR) in North Indian population. METHODS: The participants were recruited under a major government funded project through household survey covering 15 villages of Haryana, India...
April 25, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29693425/metabolic-syndrome-is-associated-with-hearing-loss-among-a-middle-aged-and-older-chinese-population-a-cross-sectional-study
#17
Xu Han, Zhichao Wang, Jing Wang, Yaru Li, Hua Hu, Yujuan Hu, Xueyan Zhao, Yue Zhan, Jing Yuan, Sheng Wei, Yuan Liang, Xiaomin Zhang, Huan Guo, Handong Yang, Tangchun Wu, Weijia Kong, Meian He
BACKGROUND: Although the association of metabolic syndrome (MetS) and hearing loss has been evaluated, findings are controversial. This study investigated this association in a Chinese population. METHODS: A cross-sectional study including a total of 18,824 middle-aged and older participants from the Dongfeng-Tongji Cohort study was conducted. Hearing loss was defined as the pure-tone average (PTA) of frequencies 0.5, 1.0, 2.0, and 4.0 kHz >25 decibels hearing level (dB HL) in the better ear and graded as mild (PTA 26-40 dB HL), moderate (PTA >40 to ≤60 dB HL), and severe (PTA >60 dB HL)...
April 25, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29678607/association-between-hypertension-and-metabolic-disorders-among-elderly-patients-in-north-jordan
#18
Nuha Alwardat, Laura Di Renzo, Renata Costa de Miranda, Sofian Alwardat, Paola Sinibaldi Salimei, Antonino De Lorenzo
BACKGROUND: Hypertension (HTN), dyslipidemia and hyperglycemia are major risk factors for cardiovascular disease, accounting for the highest morbidity and mortality among the elderly Jordanian population. This study aimed to evaluate serum lipid and glucose profiles of hypertensive patients and normotensive controls, and determine the risk factors for HTN among elderly population in Jordan. METHODS: A cross-sectional study was carried out among 200 participants, including 111 hypertensive patients and 89 normotensive controls from June to October 2017 in North Jordan...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29673340/active-commuting-to-and-from-university-obesity-and-metabolic-syndrome-among-colombian-university-students
#19
Antonio García-Hermoso, Andrea P Quintero, Enrique Hernández, Jorge Enrique Correa-Bautista, Mikel Izquierdo, Alejandra Tordecilla-Sanders, Daniel Prieto-Benavides, Carolina Sandoval-Cuellar, Katherine González-Ruíz, Emilio Villa-González, Robinson Ramírez-Vélez
BACKGROUND: There is limited evidence concerning how active commuting (AC) is associated with health benefits in young. The aim of the study was to analyze the relationship between AC to and from campus (walking) and obesity and metabolic syndrome (MetS) in a sample of Colombian university students. METHODS: A total of 784 university students (78.6% women, mean age = 20.1 ± 2.6 years old) participated in the study. The exposure variable was categorized into AC (active walker to campus) and non-AC (non/infrequent active walker to campus: car, motorcycle, or bus) to and from the university on a typical day...
April 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29668714/socioeconomic-inequalities-in-the-prevalence-of-biomarkers-of-cardio-metabolic-disease-in-south-korea-comparison-of-the-health-examinees-study-to-a-nationally-representative-survey
#20
Sujin Kim, Juhwan Oh, Jongho Heo, Hwa-Young Lee, Jong-Koo Lee, S V Subramanian, Daehee Kang
BACKGROUND/OBJECTIVES: This study aimed to examine socioeconomic inequalities in the prevalence of biomarkers of cardiovascular disease and diabetes in the newly developed large-scale genomic cohort study of Korean adults, the Health Examinees-Gem (HEXA-G), with a comparison of the nationally representative cross-sectional study, the Korea National Health and Nutrition Examination Survey (K-NHANES). SUBJECTS/METHODS: Using the HEXA-G and the K-NHANES from 2007-2012, we analyzed the age-adjusted relative risk (RR) and prevalence of enlarged waist circumference (EWC), elevated triglycerides (ET), low HDL cholesterol (LHC), elevated blood pressure (EBP) and elevated blood glucose (EBG) by income and educational groups for adults at age 40-69...
2018: PloS One
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