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https://www.readbyqxmd.com/read/29169103/impact-of-roadway-geometric-features-on-crash-severity-on-rural-two-lane-highways
#1
Nima Haghighi, Xiaoyue Cathy Liu, Guohui Zhang, Richard J Porter
This study examines the impact of a wide range of roadway geometric features on the severity outcomes of crashes occurred on rural two-lane highways. We argue that crash data have a hierarchical structure which needs to be addressed in modeling procedure. Moreover, most of previous studies ignored the impact of geometric features on crash types when developing crash severity models. We hypothesis that geometric features are more likely to determine crash type, and crash type together with other occupant, environmental and vehicle characteristics determine crash severity outcome...
November 20, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29168897/early-socioeconomic-conditions-and-severe-tooth-loss-in-middle-aged-costa-ricans
#2
Romain Fantin, Cyrille Delpierre, Michelle Kelly-Irving, Cristina Barboza Solís
OBJECTIVE: A wide literature shows a strong social gradient in tooth loss according to income, education and occupation, in both developed and developing countries. It has been shown associations between tooth loss and parental education and occupation, independently of adult conditions. To explore the role of early socioeconomic circumstances on tooth loss, we used a lifecourse model. We analysed the direct and indirect links between early socioeconomic conditions and severe adult tooth loss...
November 23, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29168801/the-histone-code-reader-spin1-controls-skeletal-muscle-development
#3
Holger Greschik, Delphine Duteil, Nadia Messaddeq, Dominica Willmann, Laura Arrigoni, Manuela Sum, Manfred Jung, Daniel Metzger, Thomas Manke, Thomas Günther, Roland Schüle
While several studies correlated increased expression of the histone code reader Spin1 with tumor formation or growth, little is known about physiological functions of the protein. We generated Spin1(M5) mice with ablation of Spin1 in myoblast precursors using the Myf5-Cre deleter strain. Most Spin1(M5) mice die shortly after birth displaying severe sarcomere disorganization and necrosis. Surviving Spin1(M5) mice are growth-retarded and exhibit the most prominent defects in soleus, tibialis anterior, and diaphragm muscle...
November 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29168261/-impact-of-drug-reimbursement-policies-on-prescribing-a-case-study-of-a-newly-marketed-long-acting-injectable-antipsychotics-among-relapsed-schizophrenia-patients
#4
John W Jackson, Lisa Fulchino, James Rogers, Helen Mogun, Jennifer Polinski, David C Henderson, Sebastian Schneeweiss, Michael A Fischer
OBJECTIVE: To quantify and explain variation in use of long-acting injectable antipsychotics (LAIs) in the United States, and understand the relationship between patient characteristics, drug reimbursement policies, and LAI prescribing after relapse. METHODS: A cohort of recently relapsed patients with schizophrenia ages 18 to 64, identified immediately after discharge from a related inpatient hospitalization, partial hospitalization, or emergency room visit, drawn from 2004 to 2006 Medicaid claims, and followed for 90 days until LAI initiation...
November 23, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29168253/genomewide-association-study-of-hla-alloimmunization-in-previously-pregnant-blood-donors
#5
Mark Seielstad, Grier P Page, Nathan Gaddis, Marion Lanteri, Tzong-Hae Lee, Ram Kakaiya, Lisa F Barcellos, Lindsey A Criswell, Darrell Triulzi, Philip J Norris, Michael P Busch
BACKGROUND: Alloimmunization through blood transfusion, transplantation, or circulating fetal cells during pregnancy is a significant concern. Some exposed individuals make alloantibodies while others do not, implying variation in genetic risk factors. STUDY DESIGN AND METHODS: We conducted a genomewide association study (GWAS) of 9,427,497 single-nucleotide polymorphisms (SNPs) to identify genetic variants for HLA alloimmunization in previously pregnant blood donors with (n = 752) and without (n = 753) HLA Class I or II alloantibodies...
November 22, 2017: Transfusion
https://www.readbyqxmd.com/read/29168249/violent-crime-redistribution-in-a-city-following-a-substantial-increase-in-the-number-of-off-sale-alcohol-outlets-a-bayesian-analysis
#6
Dennis M Gorman, William R Ponicki, Qi Zheng, Daikwon Han, Paul J Gruenewald, Andrew J Gaidus
INTRODUCTION AND AIMS: This study examined whether the introduction of a large number of off-premise alcohol outlets into a city over a brief period of time could affect rates of violent crime. DESIGN AND METHODS: The study analysed annual counts of violent crime across 172 US Census block groups in Lubbock, Texas from 2006 through 2011. Spatial Poisson models related annual violent crime counts within each block group to off-premise and on-premise alcohol outlets active during this time period as well as neighbourhood socio-demographic characteristics...
November 22, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29168192/seeing-it-differently-self-reported-description-of-vision-loss-in-dry-age-related-macular-degeneration
#7
Deanna J Taylor, Laura A Edwards, Alison M Binns, David P Crabb
PURPOSE: A realistic description of visual symptoms associated with dry age-related macular degeneration (AMD) is important for raising awareness of the condition and educating patients. This study aimed to develop a set of descriptors for dry AMD and examine the realism of images currently and frequently used to show visual symptoms of the condition. METHODS: Volunteers with dry AMD with a range of disease severity were given an eye examination and were asked to describe visual symptoms of their condition in a conversational interview...
November 23, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29168176/a-meta-analysis-of-the-relationship-between-rational-beliefs-and-psychological-distress
#8
REVIEW
Horea-Radu Oltean, Daniel Ovidiu David
OBJECTIVE:  Rational emotive behavior therapy (REBT) model of psychological health assumes that rational beliefs cause functional emotions and adaptive behavior, but the presumed role of rational beliefs as protective factor against psychological distress/disorders is still in debate. An important step in validating an evidence-based therapy is to investigate the underling theoretical assumptions. Thus, the aim of the present meta-analysis is to investigate the direction and magnitude of the relationship between rational beliefs and psychological distress...
November 23, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29168086/increased-white-matter-metabolic-rates-in-autism-spectrum-disorder-and-schizophrenia
#9
Serge A Mitelman, Monte S Buchsbaum, Derek S Young, M Mehmet Haznedar, Eric Hollander, Lina Shihabuddin, Erin A Hazlett, Marie-Cecile Bralet
Both autism spectrum disorder (ASD) and schizophrenia are often characterized as disorders of white matter integrity. Multimodal investigations have reported elevated metabolic rates, cerebral perfusion and basal activity in various white matter regions in schizophrenia, but none of these functions has previously been studied in ASD. We used (18)fluorodeoxyglucose positron emission tomography to compare white matter metabolic rates in subjects with ASD (n = 25) to those with schizophrenia (n = 41) and healthy controls (n = 55) across a wide range of stereotaxically placed regions-of-interest...
November 22, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29168065/are-vntrs-co-localizing-with-breast-cancer-associated-snps
#10
Martin Leclerc, Susan L Neuhausen, Hagit Schayek, Yael Laitman, Antoniou C Antonis, Eitan Friedman
PURPOSE: Several common genetic variants (single-nucleotide polymorphisms, SNPs) have been shown to be associated with breast cancer (BC) risk in the general population, and to modify BC risk for BRCA1 and BRCA2 mutation carriers. Co-localization of variable number of tandem repeats (VNTRs) with these BC-associated SNPS has not been comprehensively studied. METHODS: Cross referencing of genome-wide VNTRs with the known BC genome-wide association studies (GWAS) SNPs significantly associated with increased risk for developing breast cancer was carried out...
November 22, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29168042/impact-of-receiving-secondary-results-from-genomic-research-a-12-month-longitudinal-study
#11
Julia Wynn, Josue Martinez, Jessica Bulafka, Jimmy Duong, Yuan Zhang, Codruta Chiuzan, Jain Preti, Maria L Cremona, Vaidehi Jobanputra, Abby J Fyer, Robert L Klitzman, Paul S Appelbaum, Wendy K Chung
The impact of returning secondary results from exome sequencing (ES) on patients/participants is important to understand as ES is increasingly utilized in clinical care and research. Participants were recruited from studies using ES and were separated into two arms: 107 who had ES and were offered the choice to learn secondary results (ES group) and 85 who had not yet had ES (No ES group). Questionnaires were administered at baseline and 1 and 12 months, following results disclosure (ES group) or enrollment (No ES group)...
November 22, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29168041/making-sense-of-snps-women-s-understanding-and-experiences-of-receiving-a-personalized-profile-of-their-breast-cancer-risks
#12
Mary-Anne Young, Laura Elenor Forrest, Victoria-Mae Rasmussen, Paul James, Gillian Mitchell, Sarah Dilys Sawyer, Katrina Reeve, Nina Hallowell
Genome wide association studies have identified a number of common genetic variants - single nucleotide polymorphisms (SNPs) - that combine to increase breast cancer risk. SNP profiling may enhance the accuracy of risk assessment and provides a personalized risk estimate. SNP testing for breast cancer risks may supplement other genetic tests in the future, however, before it can be implemented in the clinic we need to know how it will be perceived and received. Semi-structured qualitative interviews were conducted with 39 women who had previously had a breast cancer diagnosis and undergone BRCA1/2 testing, participated in the Variants in Practice (ViP) study and received personalized risk (SNP) profiles...
November 22, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29167976/temporary-closure-of-colostomy-with-suture-before-colostomy-takedown-improves-the-postoperative-outcomes
#13
Wan-Hsiang Hu, Ko-Chao Lee, Kai-Lung Tsai, Hong-Hwa Chen
PURPOSE: Temporary loop colostomy is a common surgical procedure used to avoid complications in high-risk distal anastomosis as well as pelvic inflammation. Issues regarding postoperative outcomes of colostomy takedown have been widely discussed in the literature, wound infection especially. Temporary closure of colostomy with suture before takedown was adopted in our study, which provided excellent traction to aid mobilization of stomy and avoided stool spillage to downgrade the wound classification to "clean contamination...
November 22, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29167880/association-between-schizophrenia-related-polygenic-liability-and-the-occurrence-and-level-of-mood-incongruent-psychotic-symptoms-in-bipolar-disorder
#14
Judith Allardyce, Ganna Leonenko, Marian Hamshere, Antonio F Pardiñas, Liz Forty, Sarah Knott, Katherine Gordon-Smith, David J Porteous, Caroline Haywood, Arianna Di Florio, Lisa Jones, Andrew M McIntosh, Michael J Owen, Peter Holmans, James T R Walters, Nicholas Craddock, Ian Jones, Michael C O'Donovan, Valentina Escott-Price
Importance: Bipolar disorder (BD) overlaps schizophrenia in its clinical presentation and genetic liability. Alternative approaches to patient stratification beyond current diagnostic categories are needed to understand the underlying disease processes and mechanisms. Objective: To investigate the association between common-variant liability for schizophrenia, indexed by polygenic risk scores (PRSs), and psychotic presentations of BD. Design, Setting, and Participants: This case-control study in the United Kingdom used multinomial logistic regression to estimate differential PRS associations across categories of cases and controls...
November 22, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29167867/geographic-distribution-of-nonphysician-clinicians-who-independently-billed-medicare-for-common-dermatologic-services-in-2014
#15
Adewole S Adamson, Elizabeth A Suarez, Philip McDaniel, Paul A Leiphart, Alana Zeitany, Joslyn S Kirby
Importance: Nurse practitioners (NPs) and physician assistants (PAs) are nonphysician clinicians (NPCs) who can deliver dermatology services. Many of these services are provided independently. Little is known about the types of services provided or where NPCs provide independent care. Objective: To examine characteristics of dermatology care for Medicare enrollees billed independently by NPCs. Design, Setting, and Participants: Retrospective review of the 2014 Medicare Provider Utilization and Payment Data: Physician and Other Supplier Public Use File, which reflects fee-for-service payments to clinicians for services rendered to Medicare beneficiaries...
November 22, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29167679/effects-of-mountain-uplift-and-climatic-oscillations-on-phylogeography-and-species-divergence-in-four-endangered-notopterygium-herbs
#16
Khurram Shahzad, Yun Jia, Fu-Lin Chen, Umar Zeb, Zhong-Hu Li
Mountain uplift and climatic fluctuations are important driving forces that have affected the geographic distribution and population dynamics history of organisms. However, it is unclear how geological and climatic events might have affected the phylogeographic history and species divergence in high-alpine herbal plants. In this study, we analyzed the population demographic history and species differentiation of four endangered Notopterygium herbs on the high-altitude Qinghai-Tibetan Plateau (QTP) and adjacent areas...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29167663/metagenomic-analysis-of-the-gut-microbiome-of-the-common-black-slug-arion-ater-in-search-of-novel-lignocellulose-degrading-enzymes
#17
Ryan Joynson, Leighton Pritchard, Ekenakema Osemwekha, Natalie Ferry
Some eukaryotes are able to gain access to well-protected carbon sources in plant biomass by exploiting microorganisms in the environment or harbored in their digestive system. One is the land pulmonate Arion ater, which takes advantage of a gut microbial consortium that can break down the widely available, but difficult to digest, carbohydrate polymers in lignocellulose, enabling them to digest a broad range of fresh and partially degraded plant material efficiently. This ability is considered one of the major factors that have enabled A...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29167564/whole-transcriptome-sequencing-analyses-reveal-molecular-markers-of-blood-pressure-response-to-thiazide-diuretics
#18
Ana Caroline C Sá, Amy Webb, Yan Gong, Caitrin W McDonough, Somnath Datta, Taimour Y Langaee, Stephen T Turner, Amber L Beitelshees, Arlene B Chapman, Eric Boerwinkle, John G Gums, Steven E Scherer, Rhonda M Cooper-DeHoff, Wolfgang Sadee, Julie A Johnson
Thiazide diuretics (TD) are commonly prescribed anti-hypertensives worldwide. However, <40% of patients treated with thiazide monotherapy achieve BP control. This study uses whole transcriptome sequencing to identify novel molecular markers associated with BP response to TD. We assessed global RNA expression levels in whole blood samples from 150 participants, representing patients in the upper and lower quartile of BP response to TD from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) (50 whites) and from PEAR-2 (50 whites and 50 blacks)...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167552/association-of-ets1-polymorphism-with-granulomatosis-with-polyangiitis-and-proteinase-3-anti-neutrophil-cytoplasmic-antibody-positive-vasculitis-in-a-japanese-population
#19
Aya Kawasaki, Keita Yamashita, Fumio Hirano, Ken-Ei Sada, Daisuke Tsukui, Yuya Kondo, Yoshitaka Kimura, Kurumi Asako, Shigeto Kobayashi, Hidehiro Yamada, Hiroshi Furukawa, Kenji Nagasaka, Takahiko Sugihara, Kunihiro Yamagata, Takayuki Sumida, Shigeto Tohma, Hajime Kono, Shoichi Ozaki, Seiichi Matsuo, Hiroshi Hashimoto, Hirofumi Makino, Yoshihiro Arimura, Masayoshi Harigai, Naoyuki Tsuchiya
ETS proto-oncogene 1, transcription factor (ETS1) is involved in various immune responses. Genome-wide association studies on systemic lupus erythematosus in Chinese populations identified the association of ETS1 polymorphism in 3' untranslated region, rs1128334A, which was associated with lower ETS1 expression. In view of substantial sharing of susceptibility genes across multiple autoimmune diseases, we examined whether ETS1 is associated with a rare autoimmune rheumatic disease, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)...
October 5, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29167342/antibodies-directed-towards-neuraminidase-n1-control-disease-in-a-mouse-model-of-influenza
#20
E R Job, M Schotsaert, L I Ibañez, A Smet, T Ysenbaert, K Roose, M Dai, C A M de Haan, H Kleanthous, T U Vogel, X Saelens
There is increasing evidence to suggest that antibodies directed towards influenza A virus (IAV) neuraminidase (NA) are an important correlate of protection against influenza in humans. Moreover, the potential of NA-specific antibodies to provide broader protection than conventional hemagglutinin (HA) antibodies has been recognized. Herein, we describe the isolation of two monoclonal antibodies, N1-7D3 and N1-C4, directed towards the N1 NA. N1-7D3 binds to a conserved linear epitope in the membrane distal, carboxy-terminal part of the NA and reacted with the NA of seasonal H1N1 isolates ranging from 1977 till 2007 the 2009 H1N1pdm virus as well as A/Vietnam/1194/04 (H5N1)...
November 22, 2017: Journal of Virology
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