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https://www.readbyqxmd.com/read/28550812/molecular-characterization-of-human-adenoviruses-in-urban-wastewaters-using-next-generation-and-sanger-sequencing
#1
M Iaconelli, B Valdazo-González, M Equestre, A R Ciccaglione, C Marcantonio, S Della Libera, G La Rosa
Human adenoviruses (HAdVs) are of major public health importance and are associated with a variety of clinical manifestations, including gastroenteritis, respiratory, ocular and urinary tract infections. To study the occurrence, prevalence and diversity of HAdV species and types circulating in Italy, we conducted a large-scale molecular-epidemiological investigation, a yearlong monitoring of 22 wastewater treatment plants, covering 10 Italian regions, representative of northern, central, and southern Italy...
May 19, 2017: Water Research
https://www.readbyqxmd.com/read/28550809/the-impact-of-childhood-overweight-and-obesity-on-healthcare-utilisation
#2
Edel Doherty, Michelle Queally, John Cullinan, Paddy Gillespie
Rising levels of childhood overweight and obesity represent a major global public health challenge. A number of studies have explored the association between childhood overweight and obesity and healthcare utilisation and costs. This paper adds to the literature by estimating the causal effect of child overweight and obesity status on use of general practitioner (GP) and hospital inpatient stays at two time points using instrumental variable (IV) methods The paper uses data from two waves of the Growing Up in Ireland survey of children when they are 9 and 13 years respectively and uses the biological mother's body mass index (BMI) as an instrument for the child's BMI...
May 12, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/28550792/social-stress-contagion-in-rats-behavioural-autonomic-and-neuroendocrine-correlates
#3
Luca Carnevali, Nicola Montano, Rosario Statello, Gino Coudé, Federica Vacondio, Silvia Rivara, Pier Francesco Ferrari, Andrea Sgoifo
The negative emotional consequences associated with life stress exposure in an individual can affect the emotional state of social partners. In this study, we describe an experimental rat model of social stress contagion and its effects on social behaviour and cardiac autonomic and neuroendocrine functions. Adult male Wistar rats were pair-housed and one animal (designated as "demonstrator" (DEM)) was submitted to either social defeat stress (STR) by an aggressive male Wild-type rat in a separate room or just exposed to an unfamiliar empty cage (control condition, CTR), once a day for 4 consecutive days...
May 20, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28550773/susceptibility-resistance-and-resilience-of-anammox-biomass-to-nanoscale-copper-stress
#4
Zheng-Zhe Zhang, Hai-Yan Hu, Jia-Jia Xu, Zhi-Jian Shi, Yang-Yang Shen, Man-Ling Shi, Ren-Cun Jin
The increasing use of engineered nanoparticles (NPs) poses an emerging challenge to biological wastewater treatment. The long-term impact of CuNPs on anaerobic ammonium oxidation (anammox) process was firstly investigated in this study. The nitrogen removal capacity of anammox reactor was nearly deprived within 30days under the stress of 5.0mgL(-1) CuNPs and the relative abundance of anammox bacteria (Ca. Kuenenia) was decreased from 29.59% to 17.53%. Meanwhile, copper resistance genes associated with the Cus, Cop and Pco systems were enriched to eliminate excess intracellular copper...
May 15, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28550770/laparoscopic-versus-open-radical-nephrectomy-for-renal-cell-carcinoma-a-systematic-review-and-meta-analysis
#5
Gang Liu, Yulei Ma, Shouhua Wang, Xiancheng Han, Dianjun Gao
BACKGROUND: The aim of this study is to summarize and quantify the current evidence on the therapeutic efficacy of laparoscopic radical nephrectomy (LRN) compared with open radical nephrectomy (ORN) in patients with renal cell carcinoma (RCC) in a meta-analysis. METHODS: Data were collected by searching Pubmed, Embase, Web of Science, and ScienceDirect for reports published up to September 26, 2016. Studies that reported data on comparisons of therapeutic efficacy of LRN and ORN were included...
May 24, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28550766/gender-differences-in-quality-of-life-and-functional-disability-for-depression-outpatients-with-or-without-residual-symptoms-after-acute-phase-treatment-in-china
#6
Na Zhao, Xiaohong Wang, Wenyuan Wu, Yongdong Hu, Yajuan Niu, Xueyi Wang, Chengge Gao, Ning Zhang, Yiru Fang, Jizhong Huang, Tiebang Liu, Fujun Jia, Xuequan Zhu, Jian Hu, Gang Wang
BACKGROUND: Depression is associated with substantial personal suffering and reduced quality of life and functioning. The aim of this study was to investigate gender differences on quality of life and functional impairment of outpatients with depression after acute phase treatment. METHODS: 1503 depression outpatients were recruited from eleven hospitals in China. Subjects were evaluated with sociodemographic characteristics, history and self-report instruments, related to severity of symptoms, function and quality of life...
May 17, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28550757/serum-levels-of-peptide-cathelicidin-ll-37-in-elderly-patients-with-depression
#7
Elżbieta Kozłowska, Adam Wysokiński, Ewa Brzezińska-Błaszczyk
Cathelicidin LL-37 is a small cationic that plays an important role in antimicrobial defense, as it kills a broad spectrum of infectious agents by disrupting their membranes, including gram-positive and gram-negative bacteria, some viruses and fungi; and it neutralizes activity of bacterial endotoxins. Moreover, cathelicidin LL-37 exerts proinflammatory effect, while numerous reports indicate the role of inflammation in the development of depression. The purpose of this study was to evaluate the circulating levels of cathelicidin LL-37 in elderly depressed patients...
May 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28550741/exploring-syndrome-differentiation-using-non-negative-matrix-factorization-and-cluster-analysis-in-patients-with-atopic-dermatitis
#8
Younghee Yun, Wonmo Jung, Hyunho Kim, Bo-Hyoung Jang, Min-Hee Kim, Jiseong Noh, Seong-Gyu Ko, Inhwa Choi
Syndrome differentiation (SD) results in a diagnostic conclusion based on a cluster of concurrent symptoms and signs, including pulse form and tongue color. In Korea, there is a strong interest in the standardization of Traditional Medicine (TM). In order to standardize TM treatment, standardization of SD should be given priority. The aim of this study was to explore the SD, or symptom clusters, of patients with atopic dermatitis (AD) using non-negative factorization methods and k-means clustering analysis...
May 22, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28550734/pterostilbene-alleviates-polymicrobial-sepsis-induced-liver-injury-possible-role-of-sirt1-signaling
#9
Xiaojing Liu, Xueliang Yang, Lingna Han, Feng Ye, Min Liu, Wanhu Fan, Kai Zhang, Ying Kong, Jian Zhang, Lei Shi, Yunru Chen, Xi Zhang, Shumei Lin
Liver injury occurs frequently during sepsis. Pterostilbene (Pte), a natural dimethylated analog of resveratrol from blueberries, exerts anti-inflammatory and anti-apoptotic effects in various diseases. However, the role of Pte in sepsis-induced liver injury and its underlying mechanisms remain unknown. The current study aimed to evaluate the protective effects of Pte on sepsis-induced liver injury and its potential mechanisms. Sepsis was induced using cecal ligation and puncture (CLP) in C57BL/6 mice. Mice were administered Pte (5, 10, 15mg/kg, i...
May 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28550732/reversing-the-polarization-of-tumor-associated-macrophages-inhibits-tumor-metastasis
#10
Rufei Yuan, Shengfu Li, Hua Geng, Xin Wang, Qinglin Guan, Xiaohuan Li, Changle Ren, Xiaolin Yuan
OBJECTIVE: The M2 phenotype is dominant in tumor associated macrophages (TAM), and plays a key role in promoting tumor growth, invasion and metastasis. Converting TAM polarization from M2 to M1 may contribute to eliciting anti-tumor-specific immune responses and inhibiting tumor metastasis. In this study, the effect of reversing the polarization of TAM on tumor metastasis was investigated. METHODS: Peritoneal macrophages were obtained from BABL/c mice, and M2 polarization was induced by IL-4...
May 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28550731/xanthotoxin-suppresses-lps-induced-expression-of-inos-cox-2-tnf-%C3%AE-and-il-6-via-ap-1-nf-%C3%AE%C2%BAb-and-jak-stat-inactivation-in-raw-264-7-macrophages
#11
Seung-Bin Lee, Woo Seok Lee, Ji-Sun Shin, Dae Sik Jang, Kyung Tae Lee
Although xanthotoxin has been reported to possess skin-protective and anti-oxidative properties, its anti-inflammatory capacity has not been studied to date. Therefore, we investigated this role as well as the molecular mechanisms of xanthotoxin in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Xanthotoxin inhibited production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor (TNF-α), and interleukin-6 (IL-6) by the LPS-induced macrophages in a concentration-dependent manner. It also suppressed the LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression at the protein levels and iNOS, COX-2, TNF-α, and IL-6 at the mRNA levels...
May 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28550725/geographical-variation-and-age-related-dietary-exposure-to-arsenic-in-rice-from-bangladesh
#12
Shofiqul Islam, Mohammad Mahmudur Rahman, M R Islam, Ravi Naidu
An extensive number (965) of rice samples collected by household survey from 73 upazilas (i.e. sub-districts) in Bangladesh was analyzed to determine regional variation, distribution and associated health risks from arsenic (As). No previous study had conducted a study examining such a large number of rice samples. The mean and median concentrations of total As were 126μg/kg and 107μg/kg, respectively, ranging from between 3 and 680μg/kg. Importantly, total As levels of aromatic rice were significantly lower (average 58μg/kg) than non-aromatic rice (average 150μg/kg) and also varied with rice grain size...
May 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28550723/tyrosine-receptor-kinase-b-gene-variants-ntrk2-variants-are-associated-with-depressive-disorders-in-temporal-lobe-epilepsy
#13
Carolina Machado Torres, Marina Siebert, Hugo Bock, Suelen Mandelli Mota, Juliana Unis Castan, Francisco Scornavacca, Luiza Amaral de Castro, Maria Luiza Saraiva-Pereira, Marino Muxfeldt Bianchin
RATIONALE: Psychiatric comorbidities are highly prevalent in epilepsy, adding an important burden to the disease and profoundly affecting the quality of life of these individuals. Patients with temporal lobe epilepsy (TLE) are especially at risk to develop depression and several lines of evidence suggest that the association of depression with epilepsy might be related to common biological substrates. In this study, we test whether NTRK2 allele variants are associated with mood disorders or depressive disorders in patients with TLE...
May 24, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28550718/attachment-to-place-in-advanced-age-a-study-of-the-lilacs-nz-cohort
#14
Janine L Wiles, Anna Rolleston, Avinesh Pillai, Joanna Broad, Ruth Teh, Merryn Gott, Ngaire Kerse
An extensive body of research theorises that attachment to place is positively associated with health, particularly for older people. Building on this, we measure how indicators of attachment to place are associated with health for in people of advanced age in New Zealand. We use data from a cohort study (LiLACS NZ), which includes an indigenous Māori cohort aged 80-90 years and a non-Māori cohort aged 85 years from a mixed urban/rural region in New Zealand. Each cohort undertook a comprehensive interview and health assessment (n = 267 Māori and n = 404 non-Māori)...
May 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28550709/effect-of-renal-function-status-on-the-prognostic-value-of-heart-rate-in-acute-ischemic-stroke-patients
#15
Zhengbao Zhu, Chongke Zhong, Tian Xu, Aili Wang, Yanbo Peng, Tan Xu, Hao Peng, Chung-Shiuan Chen, Jinchao Wang, Zhong Ju, Qunwei Li, Deqin Geng, Yingxian Sun, Qingjuan Du, Yongqiu Li, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND AND AIMS: The association between heart rate and prognosis of ischemic stroke remains debatable, and whether renal function status influences the relationship between them is still not elucidated. METHODS: A total of 3923 ischemic stroke patients were included in this prospective multicenter study from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). The primary outcome was a combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after stroke...
May 19, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28550707/micrornas-correlate-with-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorder-in-a-chinese-population
#16
Jianglong Chen, Jiting Zhu, Zeng Wang, Xiaoping Yao, Xuan Wu, Fang Liu, Weidong Zheng, Zhiwen Li, Aiyu Lin
BACKGROUND Recent studies identified a set of differentially expressed miRNAs in whole blood that may discriminate neuromyelitis optica spectrum disorders (NMOSD) from relapsing-remitting multiple sclerosis (RRMS). This study invalidated 9 known miRNAs in Chinese patients. MATERIAL AND METHODS The levels of miRNAs in whole blood were assayed in healthy controls (n=20) and patients with NMOSD (n=45), RRMS (n=17) by quantitative real-time polymerase chain reaction (qRT-PCR), and pairwise-compared between groups...
May 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28550686/microrna-186-suppresses-cell-proliferation-and-metastasis-through-targeting-sentrin-specific-protease-1-in-renal-cell-carcinoma
#17
Dan Jiao, Man Wu, Lei Ji, Feng Liu, Yingying Liu
Recent evidence suggests that dysregulation of microRNAs are associated with the development of multiple malignancies.miR-186 has been reported as a critical cancer regulator in several types of cancers. However, its functional significance and molecular mechanism underlying renal cell carcinoma (RCC) remains unknown. In this study, our results showed that miR-186 expression was dramatically downregulated in RCC tissues and cell lines compared to that in adjacent normal tissues and cell lines. Overexpression of miR-186 significantly inhibited cell growth, colony formation, cell invasion, caused cell cycle arrest at G0/G1 phase, and induced cell apoptosis as detected by MTT, colony formation, Transwell assay, and flow cytometry assays in RCC cells...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550684/long-noncoding-rna-ccat2-knockdown-suppresses-tumorous-progression-by-sponging-mir-424-in-epithelial-ovarian-vancer
#18
Fu Hua, Chang-Hua Li, Xiao-Gang Chen, Xiao-Ping Liu
Epithelial ovarian cancer (EOC) is the one of most common gynecological malignant tumor with highest mortality, meanwhile, series of lncRNAs have been validated to play vital role in EOC tumorigenesis. Colon cancer-associated transcript 2 (CCAT2) has been verified as oncogenic lncRNA in multiple tumors, however, the role of CCAT2 in EOC genesis is still unclear. The purpose of present study is to probe the function of CCAT2 on EOC. Preliminary experiments found that CCAT2 expression was significantly up-regulated in EOC tissue and cell lines compared to noncancerous tissue and cells...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550681/antibiotic-associated-manipulation-of-the-gut-microbiota-and-phenotypic-restoration-in-nod-mice
#19
James R Fahey, Bonnie L Lyons, Haiyan L Olekszak, Anthony J Mourino, Jeremy J Ratiu, Jeremy J Racine, Harold D Chapman, David V Serreze, Dina L Baker, N Ken Hendrix
Segmented filamentous bacterium (SFB) a gram-positive, anaerobic, and intestinal commensal organism directly influencesthe development of Th17 helper cells in the small intestine of mice. In NOD mice, SFB colonization interferes with the developmentof type 1 diabetes (T1D), a T-cell-mediated autoimmune disease, suggesting that SFB may influence Th17 cells to inhibit Th1populations associated with the anti-β-cell immune response. This effect is a serious concern for investigators who use NOD micefor diabetes research because the expected incidence of disease decreases markedly when they are colonized by SFB...
May 26, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28550678/knockdown-of-long-noncoding-rna-lncrna-metastasis-associated-lung-adenocarcinoma-transcript-1-malat1-inhibits-proliferation-migration-and-invasion-and-promoted-apoptosis-by-targeting-mir-124-in-retinoblastoma
#20
Shujun Liu, Guigang Yan, Junfu Zhang, Lianzhi Yu
Evidence suggests that the long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation. However, the underlying mechanisms regarding the role of MALAT1 in retinoblastoma (RB) remains unclear. This study aimed to explore the functional role of MALAT1 in RB by targeting miR-124. Results showed that the expression of - MALAT1 was significantly higher in Y79 cell line than ARPE-19 cell line (P<0...
May 21, 2017: Oncology Research
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