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https://www.readbyqxmd.com/read/29456218/renal-anemia-syndromes-in-iraqi-hemodialysis-patients-according-to-iron-status
#1
Ala Ali, Riyadh M Salih
Anemia is common in patients on hemodialysis (HD). Adequate iron stores are essential for achieving the best hemoglobin level through maximum benefit from erythropoiesis-stimulating agents (ESA). Decreased iron stores or decreased availability of iron are the most common reasons for resistance to the effect of these agents. Our objective was to categorize a group of Iraqi HD patients according to absolute or functional iron deficiency anemia (IDA); this study was conducted in the HD unit of the Baghdad Teaching Hospital from October 2012 to January 2013...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29455909/elevated-tissue-sodium-deposition-in-patients-with-type-2-diabetes-on-hemodialysis-detected-by-23-na-magnetic-resonance-imaging
#2
Christoph Kopp, Peter Linz, Carolin Maier, Peter Wabel, Matthias Hammon, Armin M Nagel, Daniela Rosenhauer, Stephan Horn, Michael Uder, Friedrich C Luft, Jens Titze, Anke Dahlmann
Long-term elevated blood sugar levels result in tissue matrix compositional changes in patients with diabetes mellitus type 2 (T2DM). We hypothesized that hemodialysis patients with T2DM might accumulate more tissue sodium than control hemodialysis patients. To test this,23 Na magnetic resonance imaging (23 Na MRI) was used to estimate sodium in skin and muscle tissue in hemodialysis patients with or without T2DM. Muscle fat content was estimated by1 H MRI and tissue sodium content by23 Na MRI pre- and post-hemodialysis in ten hemodialysis patients with T2DM and in 30 matched control hemodialysis patients...
February 15, 2018: Kidney International
https://www.readbyqxmd.com/read/29451618/the-association-of-vitamin-d-levels-and-the-frailty-phenotype-among-non-geriatric-dialysis-patients-a-cross-sectional-study
#3
Demet Tekdos Demircioglu
OBJECTIVES: The aim of this study was to investigate the frequency of frailty and the association of vitamin D levels and the frailty phenotype among non-geriatric dialysis patients. METHOD: Seventy-four stable, chronic hemodialysis patients from the hemodialysis unit of the hospital were enrolled in the study. The patients' medical histories and laboratory findings were obtained from the medical records of the dialysis unit. Serum parathyroid hormone and 25-hydroxy vitamin D levels were determined using chemiluminometric immunoassays...
2018: Clinics
https://www.readbyqxmd.com/read/29429752/patterns-of-clinical-response-to-eculizumab-in-patients-with-c3-glomerulopathy
#4
Moglie Le Quintrec, Anne-Laure Lapeyraque, Arnaud Lionet, Anne-Laure Sellier-Leclerc, Yahsou Delmas, Véronique Baudouin, Eric Daugas, Stéphane Decramer, Leila Tricot, Mathilde Cailliez, Philippe Dubot, Aude Servais, Catherine Mourey-Epron, Franck Pourcine, Chantal Loirat, Véronique Frémeaux-Bacchi, Fadi Fakhouri
BACKGROUND: Cases reports and small series of patients with C3 glomerulopathy have reported variable efficacy of eculizumab. STUDY DESIGN: Case series of C3 glomerulopathy. SETTING & PARTICIPANTS: Pediatric and adult patients with C3 glomerulopathy treated with eculizumab between 2010 and 2016 were identified through the C3 glomerulopathy French registry database, and a questionnaire was sent to participating French pediatric and adult nephrology centers, as well as one pediatric referral center in Québec, Canada...
February 8, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29415664/gender-related-differences-in-clinicopathological-characteristics-and-renal-outcomes-of-chinese-patients-with-iga-nephropathy
#5
Wei Deng, Xiaojun Tan, Qian Zhou, Zhen Ai, Wenting Liu, Wei Chen, Xueqing Yu, Qiongqiong Yang
BACKGROUND: The prognostic effect of gender on immunoglobulin A nephropathy (IgAN) is not clear. We explored gender-related differences in clinicopathological features and renal outcomes in IgAN. METHODS: This was a single-centre retrospective study. Patients were divided into two groups according to gender. The clinicopathological features at biopsy and renal outcomes during the follow-up were collected and analysed. Renal outcomes were defined as the doubling of baseline serum creatinine and end-stage renal disease (ESRD) (estimated glomerular filtration rate < 15 mL/min/1...
February 7, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29414836/estimating-of-residual-kidney-function-by-multi-frequency-bioelectrical-impedance-analysis-in-hemodialysis-patients-without-urine-collection
#6
Ilia Beberashvili, Tatyana Yermolayeva, Anna Katkov, Nedal Garra, Leonid Feldman, Oleg Gorelik, Kobi Stav, Shai Efrati
BACKGROUND/AIMS: Residual kidney function (RKF) is a pivotal predictor of better clinical outcomes in maintenance hemodialysis (MHD) patients. So far there has been no attempt to use bioimpedance analysis (BIA) measurements to calculate residual glomerular filtration rate (GFR) in dialysis population. We hypothesized that performing of multi-frequency BIA at the beginning and end of hemodialysis session can enable us to predict the measured residual GFR in MHD patients. Thus our aim was to develop and validate a new RKF prediction equation using multi-frequency BIA in MHD patients...
January 31, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29394966/factors-affecting-dermatological-manifestations-in-patients-with-end-stage-renal-disease
#7
Muhammad Anees, Ghazala Butt, Shaista Gull, Asif Nazeer, Ijaz Hussain, Muhammad Ibrahim
OBJECTIVE: To determine skin changes in patients of End Stage Renal Disease (ESRD) on maintenance hemodialysis (MHD) and factors affecting these changes. STUDY DESIGN: Cross-sectional observational study. PLACE AND DURATION OF STUDY: Nephrology Department, Mayo Hospital, Lahore in collaboration with Dermatology Department, King Edward Medical University, Lahore, from October 2015 to January 2016. METHODOLOGY: Two hundred patients who were undergoing MHD for more than three months were included in the study...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29392681/investigation-on-solution-to-gel-characteristic-of-thermosensitive-and-mucoadhesive-biopolymers-for-the-development-of-moxifloxacin-loaded-sustained-release-periodontal-in-situ-gels
#8
Ravi Sheshala, Soo Ying Quah, Giok Choo Tan, Venkata Srikanth Meka, Naveen Jnanendrappa, Priyadarshi Soumyaranjan Sahu
The objectives of present research were to develop and characterize thermosensitive and mucoadhesive polymer-based sustained release moxifloxacin in situ gels for the treatment of periodontal diseases. Poloxamer- and chitosan-based in situ gels are in liquid form at room temperature and transform into gel once administered into periodontal pocket due to raise in temperature to 37 °C. Besides solution-to-gel characteristic of polymers, their mucoadhesive nature aids the gel to adhere to mucosa in periodontal pocket for prolonged time and releases the drug in sustained manner...
February 1, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29390237/-customization-of-hemodialysis-therapy-dialysis-is-not-a-washing-machine
#9
EDITORIAL
Antonio Santoro
In recent years, the population of chronic dialysis has grown in number but also in age and frequency of co-morbidies such as cardiac diseases, vascular pathologies, diabetes, etc. The majority of patients on chronic hemodialysis are over 70 years and, given the high number of comorbidities, they often exhibit poor tolerance to dialysis treatments. A non-tolerated dialytic treatment can have side-effects that would require an intensification of the dialysis sessions and many hospitalizations. Consequently, the problematic dialysis treatments, as well as harmful for the patient, become economically more detrimental than other treatments apparently more expensive but more tolerated ones In the current days we have, thanks to the huge developments in dialysis technology, powerful weapons to ensure effective and scarcely symptomatic dialysis treatments to the majority of the HD patients...
February 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29375884/implementation-and-evaluation-of-a-risk-based-approach-to-guide-chronic-kidney-disease-care-protocol-for-a-multiphase-mixed-methods-study
#10
Brenda R Hemmelgarn, Michelle D Smekal, Robert G Weaver, Chandra Thomas, Eleanor Benterud, Kin Tam, Braden J Manns, Marcello Tonelli, Juli Finlay, Maoliosa Donald, Helen Tam-Tham, Aminu Bello, Navdeep Tangri, Robert R Quinn
Background: Risk prediction tools are used in a variety of clinical settings to guide patient care, although their use in chronic kidney disease (CKD) care is limited. Objectives: To assess the association of a risk-based model of CKD care on patient care, satisfaction, outcomes, and cost. Design: Mixed-methods with a pre-post design. Setting: We will use mixed-methods and a pre-post design to evaluate use of the Kidney Failure Risk Equation (KFRE) to guide CKD care...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29374356/altered-intrinsic-brain-activity-and-memory-performance-improvement-in-patients-with-end-stage-renal-disease-during-a-single-dialysis-session
#11
Peng Li, Dun Ding, Xue-Ying Ma, Hua-Wen Zhang, Ji-Xin Liu, Ming Zhang
Memory deficits are considered to have a great influence on self-management, dietary restriction and therapeutic regimen for end-stage renal disease (ESRD) patients with dialysis treatment. This study was aim to investigate the spontaneous brain activity and its relationship with memory performance in ESRD patients before dialysis (T1) and after 24 h (T2) during a single dialysis session. 23 ESRD patients and 25 matched healthy controls (HCs) were scanned using functional magnetic resonance imaging (fMRI) at T1, and all patients were also scanned at T2...
January 26, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29373244/race-and-sex-disparities-in-outcomes-of-dialysis-access-maintenance-interventions
#12
Premal S Trivedi, Kimberly E Lind, Charles E Ray, Paul J Rochon, Robert K Ryu
PURPOSE: To determine whether utilization and outcomes of dialysis access maintenance interventions vary by patient race or sex. MATERIALS AND METHODS: Data for this retrospective cohort study of first-time arteriovenous (AV) access recipients were drawn from a 5% sample of Medicare beneficiaries, containing claims from all clinical settings (2009-2014) in 2,693 patients who received their first AV fistula/graft in 2009. Maintenance interventions-angiography, angioplasty, thrombolysis, stent placement, and venous embolization-were identified by corresponding Current Procedural Terminology codes...
January 17, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29364798/-selection-of-donor-recipient-pairs-in-renal-transplantation-comparative-simulation-results
#13
Bruno Alves Lima, Helena Alves
INTRODUCTION: Implemented in 2007 by Ordinance No. 6357, allocation rules of cadaveric donor kidneys seek to distribute equitably a scarce community resource to patients who can improve their survival and quality of life. As stated in the aforementioned ordinance these rules must be updated whenever the state of the art recommends it. The objective of this work is to evaluate and compare three cadaveric donor allocation models: scoring criteria of ordinance nº 6537/2007 (model 1); similar to the previous model but with a lower score for the dialysis time (model 2); and a model adapted from the previously proposed color allocation system (model 3)...
December 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29361078/outcome-of-autosomal-dominant-polycystic-kidney-disease-patients-on-peritoneal-dialysis-a-national-retrospective-study-based-on-two-french-registries-the-french-language-peritoneal-dialysis-registry-and-the-french-renal-epidemiology-and-information-network
#14
Mickael Sigogne, Lukshe Kanagaratnam, Vincent Dupont, Cécile Couchoud, Christian Verger, Hervé Maheut, Marc Hazzan, Jean Michel Halimi, Coralie Barbe, Eric Canivet, Andréea Petrache, Moustapha Dramé, Philippe Rieu, Fatouma Touré
Background: Pathological features of autosomal dominant polycystic kidney disease (ADPKD) include enlarged kidney volume, higher frequency of digestive diverticulitis and abdominal wall hernias. Therefore, many nephrologists have concerns about the use of peritoneal dialysis (PD) in ADPKD patients. We aimed to analyse survival and technique failure in ADPKD patients treated with PD. Methods: We conducted two retrospective studies on patients starting dialysis between 2000 and 2010...
January 17, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29360160/trends-in-multiple-myeloma-presentation-management-cost-of-care-and-outcomes-in-the-medicare-population-a-comprehensive-look-at-racial-disparities
#15
Sikander Ailawadhi, Ryan D Frank, Mayank Sharma, Richa Menghani, M'hamed Temkit, Shumail Paulus, Nandita Khera, Shahrukh Hashmi, Pooja Advani, Abhisek Swaika, Aneel Paulus, Nabeel Aslam, Taimur Sher, Vivek Roy, Gerardo Colon-Otero, Asher Chanan-Khan
BACKGROUND: Outcomes have improved significantly in multiple myeloma (MM), but racial disparities in health care access and survival exist. A comprehensive analysis exploring MM care and racial disparities is warranted. METHODS: Patients with MM from 1991 to 2010 in the Surveillance, Epidemiology, and End Results-Medicare database were evaluated for racial trends in clinical myeloma-defining events (MDEs), the receipt of treatment (drugs and stem cell transplantation; [SCT]), the cost of care, and overall survival (OS)...
January 23, 2018: Cancer
https://www.readbyqxmd.com/read/29340327/trimethoprim-sulfamethoxazole-reduces-rates-of-melioidosis-in-high-risk-hemodialysis-patients
#16
Sandawana William Majoni, Jaquelyne T Hughes, Bianca Heron, Bart J Currie
Introduction: Melioidosis causes sepsis and death in the Top End of Northern Australia during the monsoonal wet season. Dialysis-dependent adults suffer higher melioidosis rates compared to low rates among renal transplant patients who routinely receive trimethoprim+sulfamethoxazole prophylaxis. Methods: We performed a prospective interventional study to determine the efficacy and safety of daily trimethoprim+sulfamethoxazole prophylaxis in hemodialysis patients during the wet season, from 1 November 2014 to 30 April 2015...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29326306/weekly-standard-kt-vurea-and-clinical-outcomes-in-home-and-in-center-hemodialysis
#17
Matthew B Rivara, Vanessa Ravel, Elani Streja, Yoshitsugu Obi, Melissa Soohoo, Alfred K Cheung, Jonathan Himmelfarb, Kamyar Kalantar-Zadeh, Rajnish Mehrotra
BACKGROUND AND OBJECTIVES: Patients undergoing hemodialysis with a frequency other than thrice weekly are not included in current clinical performance metrics for dialysis adequacy. The weekly standard Kt/Vurea incorporates treatment frequency, but there are limited data on its association with clinical outcomes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used multivariable regression to examine the association of dialysis standard Kt/Vurea with BP and metabolic control (serum potassium, calcium, bicarbonate, and phosphorus) in patients incidental to dialysis treated with home (n=2373) or in-center hemodialysis (n=109,273)...
January 11, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29324682/malnutrition-inflammation-atherosclerosis-syndrome-mia-and-diet-recommendations-among-end-stage-renal-disease-patients-treated-with-maintenance-hemodialysis
#18
Małgorzata Maraj, Beata Kuśnierz-Cabala, Paulina Dumnicka, Agnieszka Gala-Błądzińska, Katarzyna Gawlik, Dorota Pawlica-Gosiewska, Anna Ząbek-Adamska, Małgorzata Mazur-Laskowska, Piotr Ceranowicz, Marek Kuźniewski
Malnutrition-inflammation-atherosclerosis syndrome is one of the causes of increased mortality in chronic kidney disease (CKD). The aim of the study was to assess the inflammation and nutritional status of patients in end-stage kidney disease treated with maintenance hemodialysis. The study included a group of 98 hemodialyzed patients with stage 5 CKD (38 women and 60 men). Albumin, prealbumin (PRE), and C-reactive protein (CRP) were measured in serum samples collected before mid-week dialysis. Fruit and vegetables frequency intakes were assessed with a questionnaire...
January 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29321346/mutational-screening-of-pkd2-gene-in-the-north-indian-polycystic-kidney-disease-patients-revealed-28-genetic-variations
#19
Sonam Raj, Rana Gopal Singh, Parimal Das
Polycystic kidney disease (PKD) is a systemic disorder which adds majority of renal patients to end stage renal disease. Autosomal dominant polycystic kidney disease (ADPKD) is more prevalent and leading cause of dialysis and kidney transplant. Linkage analysis revealed some closely linked loci, two of which are identified as PKD1, PKD2 and an unidentified locus to ADPKD. This study was performed using PCR and automated DNA sequencing in 84 cases and 80 controls to test potential candidature of PKD2 as underlying cause of PKD by in silico and statistical analyses...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29318742/extracellular-water-excess-and-increased-self-reported-fatigue-in-chronic-hemodialysis-patients
#20
Kamonwan Tangvoraphonkchai, Andrew Davenport
Hemodialysis patients (HD) commonly report fatigue. Muscle wasting (sarcopenia) and extracellular water (ECW) excess have been reported to be associated with fatigue in other conditions. We wished to determine whether muscle loss and ECW excess were associated with fatigue in HD patients. Patients completed the Multidimensional Fatigue Inventory (MFI), Beck Depression Inventory-II (BDI-II), Patient Health Questionnaires (PHQ-9) and recorded their post-dialysis recovery time. Sessional dialysis data were recorded along with pre- and post-dialysis multi-frequency bioimpedance assessments (MFBIA)...
January 10, 2018: Therapeutic Apheresis and Dialysis
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