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https://www.readbyqxmd.com/read/28811956/spectrophotometric-methods-for-simultaneous-determination-of-oxytetracycline-hcl-and-flunixin-meglumine-in-their-veterinary-pharmaceutical-formulation
#1
Hanan A Merey, Mahmmoud S Abd-Elmonem, Hagar N Nazlawy, Hala E Zaazaa
Four precise, accurate, selective, and sensitive UV-spectrophotometric methods were developed and validated for the simultaneous determination of a binary mixture of Oxytetracycline HCl (OXY) and Flunixin Meglumine (FLU). The first method, dual wavelength (DW), depends on measuring the difference in absorbance (ΔA 273.4-327 nm) for the determination of OXY where FLU is zero while FLU is determined at ΔA 251.7-275.7 nm. The second method, first-derivative spectrophotometric method (1D), depends on measuring the peak amplitude of the first derivative selectively at 377 and 266...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28795905/challenges-in-preparing-veterinarians-for-global-animal-health-understanding-the-public-sector
#2
Paul J Hollier, Kaylee A Quinn, Corrie C Brown
Understanding of global systems is essential for veterinarians seeking to work in realms outside of their national domain. In the global system, emphasis remains on the public sector, and the current curricular emphasis in developed countries is on private clinical practice for the domestic employment market. There is a resulting lack of competency at graduation for effective engagement internationally. The World Organisation for Animal Health (OIE) has created standards for public sector operations in animal health, which must be functional to allow for sustainable development...
August 10, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28770337/overexpression-of-biologically-safe-rorippa-indica-defensin-enhances-aphid-tolerance-in-brassica-juncea
#3
Poulami Sarkar, Kuladip Jana, Samir Ranjan Sikdar
Transgenic mustard plants ( Brassica juncea ) expressing non-allergenic and biologically safe RiD peptide show higher tolerance against Lipaphis erysimi. Rorippa indica defensin (RiD) has previously been reported as a novel insecticidal protein derived from a wild crucifer Rorippa indica. RiD was found to have an effective insecticidal property against mustard aphid, Lipaphis erysimi. In the present study, RiD was highly upregulated in R. indica during aphid infestation initiating a defense system mediated by jasmonic acid (JA), but not by salicylic acid (SA)/abscisic acid (ABA)...
August 2, 2017: Planta
https://www.readbyqxmd.com/read/28757310/recommendations-for-harmonization-of-data-collection-and-analysis-of-developmental-neurotoxicity-endpoints-in-regulatory-guideline-studies-proceedings-of-workshops-presented-at-society-of-toxicology-and-joint-teratology-society-and-neurobehavioral-teratology
#4
REVIEW
Abby A Li, Larry P Sheets, Kathleen Raffaele, Virginia Moser, Angela Hofstra, Alan Hoberman, Susan L Makris, Robert Garman, Brad Bolon, Wolfgang Kaufmann, Roland Auer, Edmund Lau, Thomas Vidmar, Wayne J Bowers
The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, and morphometric data that are evaluated by regulatory agencies globally. Data from these DNT guideline studies, or the more recent OECD extended one-generation reproductive toxicity guideline, play a pivotal role in children's health risk assessment in different world areas...
July 27, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28671491/seroprevalences-of-feline-leukemia-virus-and-feline-immunodeficiency-virus-infection-in-cats-in-the-united-states-and-canada-and-risk-factors-for-seropositivity
#5
Amie N Burling, Julie K Levy, H Morgan Scott, Michael M Crandall, Sylvia J Tucker, Erin G Wood, Jessie D Foster
OBJECTIVE To estimate seroprevalences for FeLV antigen and anti-FIV antibody and risk factors for seropositivity among cats in the United States and Canada. DESIGN Cross-sectional study. ANIMALS 62,301 cats tested at 1,396 veterinary clinics (n = 45,406) and 127 animal shelters (16,895). PROCEDURES Blood samples were tested with a point-of-care ELISA for FeLV antigen and anti-FIV antibody. Seroprevalence was estimated, and risk factors for seropositivity were evaluated with bivariate and multivariable mixed-model logistic regression analyses adjusted for within-clinic or within-shelter dependencies...
July 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28670210/compliance-of-systematic-reviews-in-veterinary-journals-with-preferred-reporting-items-for-systematic-reviews-and-meta-analysis-prisma-literature-search-reporting-guidelines
#6
Lorraine C Toews
OBJECTIVE: Complete, accurate reporting of systematic reviews facilitates assessment of how well reviews have been conducted. The primary objective of this study was to examine compliance of systematic reviews in veterinary journals with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines for literature search reporting and to examine the completeness, bias, and reproducibility of the searches in these reviews from what was reported. The second objective was to examine reporting of the credentials and contributions of those involved in the search process...
July 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28651194/reference-intervals-for-hematological-and-biochemical-parameters-acute-phase-proteins-and-markers-of-oxidation-in-holstein-dairy-cows-around-3-and-30days-after-calving
#7
Pierangelo Moretti, Saverio Paltrinieri, Erminio Trevisi, Monica Probo, Annarita Ferrari, Andrea Minuti, Alessia Giordano
The establishment of specific reference intervals (RIs) is advisable when different metabolic conditions in the patient population are present or when existing RIs are not suitable. Holstein dairy cows, at the start of lactation, experience a negative energy balance and an altered immune function that can lead to different levels of blood parameters compared with cows at peak lactation. The aim of this study was the determination of RIs for Holstein cows at 3±1 and 30±3days in milk. To this aim, 145 cows, from 4 herds, were sampled...
June 20, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28649570/evaluating-checklist-use-in-companion-animal-wellness-visits-in-a-veterinary-teaching-hospital-a-preliminary-study
#8
Michael T Nappier, Virginia K Corrigan, Lara E Bartl-Wilson, Mark Freeman, Stephen Werre, Eric Tempel
The number of companion animal wellness visits in private practice has been decreasing, and one important factor cited is the lack of effective communication between veterinarians and pet owners regarding the importance of preventive care. Checklists have been widely used in many fields and are especially useful in areas where a complex task must be completed with multiple small steps, or when cognitive fatigue is evident. The use of checklists in veterinary medical education has not yet been thoroughly evaluated as a potential strategy to improve communication with pet owners regarding preventive care...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28630703/energy-requirements-for-growth-in-the-yorkshire-terrier
#9
Janet E Alexander, Alison Colyer, Penelope J Morris
The 2006 National Research Council (NRC) equation calculating puppy energy requirements does not account for reported breed differences in growth pattern. Energy requirements of toy breed puppies are unknown and it is unclear whether feeding guidelines should differ between breeds. Energy requirements of Yorkshire terrier (YT) puppies were observed over their first year of life and compared with those predicted by the NRC and those previously observed in large (Labrador retriever) and medium (miniature Schnauzer; MS) breed puppies...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28619161/antimicrobials-used-for-surgical-prophylaxis-by-companion-animal-veterinarians-in-australia
#10
Laura Y Hardefeldt, Glenn F Browning, Karin Thursky, James R Gilkerson, Helen Billman-Jacobe, Mark A Stevenson, Kirsten E Bailey
Antimicrobials are widely used in veterinary practices, but there has been no investigation into the classes of antimicrobials used or the appropriateness of their use in surgical prophylaxis. Antimicrobial usage guidelines were published by the Australian Infectious Disease Advisory Panel (AIDAP) in 2013, but there has been no investigation of compliance with them. This study aimed to investigate antimicrobial use for surgical prophylaxis in companion animal practice and assess compliance with AIDAP guidelines for selected conditions by conducting a cross-sectional study of antimicrobial usage patterns of Australian veterinarians using an online questionnaire...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28619141/a-cross-sectional-study-of-oral-antibacterial-treatment-patterns-in-relation-to-specific-diarrhoeal-pathogens-in-weaner-pigs
#11
Vibeke F Jensen, Sven-Erik L Jorsal, Nils Toft
According to international guidelines, the use of antibacterials should be evidence based and prudent. This register-based, cross-sectional study investigates the potential effect of laboratory findings on the patterns of antibacterial oral (batch) medication of weaner pigs, and the level of compliance with national guidelines for antibacterial use. The study population includes 1,736 weaner herds (≈65% of all Danish weaner pigs) that were subject to laboratory analysis from the National Veterinary Institute on Brachyspira pilosicoli, Lawsonia intracellularis, and E...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28608525/antimicrobials-used-for-surgical-prophylaxis-by-equine-veterinary-practitioners-in-australia
#12
L Y Hardefeldt, G F Browning, K Thursky, J R Gilkerson, H Billman-Jacobe, M A Stevenson, K E Bailey
BACKGROUND: Antimicrobials are widely used in Australian veterinary practices, but no investigation into the classes of antimicrobials used or the appropriateness of use in horses has been conducted. OBJECTIVES: The aim of the study was to describe antimicrobial use for surgical prophylaxis in equine practice in Australia. STUDY DESIGN: Cross-sectional questionnaire survey. METHODS: An online questionnaire was used to document antimicrobial usage patterns...
June 13, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28603717/assessment-of-the-risk-to-public-health-due-to-use-of-antimicrobials-in-pigs-an-example-of-pleuromutilins-in-denmark
#13
Lis Alban, Johanne Ellis-Iversen, Margit Andreasen, Jan Dahl, Ute W Sönksen
Antibiotic consumption in pigs can be optimized by developing treatment guidelines, which encourage veterinarians to use effective drugs with low probability of developing resistance of importance for human health. In Denmark, treatment guidelines for use in swine production are currently under review at the Danish Veterinary and Food Administration. Use of pleuromutilins in swine has previously been associated with a very low risk for human health. However, recent international data and sporadic findings of novel resistance genes suggest a change of risk...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28596049/modern-science-for-better-quality-control-of-medicinal-products-towards-global-harmonization-of-3rs-in-biologicals-the-report-of-an-epaa-workshop
#14
Katrin Schutte, Anna Szczepanska, Marlies Halder, Klaus Cussler, Ursula G Sauer, Catrina Stirling, Sylvie Uhlrich, Iwona Wilk-Zasadna, David John, Martin Bopst, Joerg Garbe, Harrie L Glansbeek, Robin Levis, Pieter-Jan Serreyn, Dean Smith, Paul Stickings
This article summarizes the outcome of an international workshop organized by the European Partnership for Alternative Approaches to Animal Testing (EPAA) on Modern science for better quality control of medicinal products: Towards global harmonization of 3Rs in biologicals. As regards the safety testing of biologicals, the workshop participants agreed to actively encourage the deletion of abnormal toxicity tests and target animal batch safety tests from all relevant legal requirements and guidance documents (country-specific guidelines, pharmacopoeia monographs, WHO recommendations)...
June 5, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28588496/clinical-efficacy-and-residue-depletion-of-10-enrofloxacin-enteric-coated-granules-in-pigs
#15
Zhixin Lei, Qianying Liu, Bing Yang, Jincheng Xiong, Kun Li, Saeed Ahmed, Liping Hong, Pin Chen, Qigai He, Jiyue Cao
A new, more palatable formulation of 10% enrofloxacin enteric-coated granules was investigated to evaluate the pharmacokinetic effect in plasma, the residue elimination in tissues and the clinical efficacy against Actinobacillus pleuropneumonia (APP) and Mycoplasam suis (MS) in pigs. In this study, the enrofloxacin concentrations in plasma and tissues were detected using high-performance liquid chromatography with phosphate buffer (pH = 3) and acetonitrile. The pharmacokinetics and elimination of enrofloxacin enteric-coated granules were performed after oral administration at a single dose of 10 mg/kg body weight (bw) and 5 mg/kg twice per day for 5 consecutive days, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28583045/recommendations-for-clinical-pathology-data-generation-interpretation-and-reporting-in-target-animal-safety-studies-for-veterinary-drug-development
#16
William Siska, Aradhana Gupta, Lindsay Tomlinson, Niraj Tripathi, Barbara von Beust
Clinical pathology testing is routinely performed in target animal safety studies in order to identify potential toxicity associated with administration of an investigational veterinary pharmaceutical product. Regulatory and other testing guidelines that address such studies provide recommendations for clinical pathology testing but occasionally contain outdated analytes and do not take into account interspecies physiologic differences that affect the practical selection of appropriate clinical pathology tests...
July 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28579307/tricuspid-annular-plane-systolic-excursion-in-dogs-with-myxomatous-mitral-valve-disease-with-and-without-pulmonary-hypertension
#17
H Poser, M Berlanda, M Monacolli, B Contiero, A Coltro, C Guglielmini
OBJECTIVES: To evaluate tricuspid annular plane systolic excursion (TAPSE) in dogs with myxomatous mitral valve disease (MMVD) with or without pulmonary hypertension (PH) and to study the correlations with clinical and echocardiographic parameters. ANIMALS: The study population included 99 dogs with MMVD and tricuspid regurgitation. METHODS: This is a prospective clinical study. All dogs received a transthoracic echocardiographic evaluation, including 2D, M-mode, echo-Doppler, and tissue Doppler measurements...
June 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28557061/classification-of-involuntary-movements-in-dogs-myoclonus-and-myotonia
#18
REVIEW
M Lowrie, L Garosi
Myoclonus is a sudden brief, involuntary muscle jerk. Of all the movement disorders, myoclonus is the most difficult to encapsulate into any simple framework. On the one hand, a classification system is required that is clinically useful to aid in guiding diagnosis and treatment. On the other hand, there is need for a system that organizes current knowledge regarding biological mechanisms to guide scientific research. These 2 needs are distinct, making it challenging to develop a robust classification system suitable for all purposes...
July 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28535123/topical-otic-drugs-in-a-multi-purpose-manufacturing-facility-a-guide-on-determination-and-application-of-permitted-daily-exposure-pde
#19
Lisa Wiesner, Maarten Prause, Ester Lovsin Barle
Due to newly introduced EU GMP (Good Manufacturing Practice) guideline for Medicinal Products for Human and Veterinary use, product specific permitted daily exposure (PDE) for toxicological evaluation in multi-purpose facilities are required within a documented process for risk assessment. European Medicines Agency (EMA) guidance on setting PDE limits so far focused on systemic administration routes such as intravenous (IV), oral or inhalation. This article provides guidance on setting PDE values for risk management purposes in multi-purpose facilities for active pharmaceutical ingredients (APIs) applied as topical otic drugs to the outer ear canal...
June 7, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28516495/introduction-to-the-world-association-for-veterinary-dermatology-and-the-clinical-consensus-guidelines
#20
EDITORIAL
Aiden Foster, Wayne Rosenkrantz, Catherine Outerbridge, Tony Barnett
No abstract text is available yet for this article.
June 2017: Veterinary Dermatology
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