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https://www.readbyqxmd.com/read/28212319/a-validated-stability-indicating-hplc-method-for-simultaneous-determination-of-amoxicillin-and-enrofloxacin-combination-in-an-injectable-suspension
#1
Nidal Batrawi, Shorouq Wahdan, Fuad Al-Rimawi
The combination of amoxicillin and enrofloxacin is a well-known mixture of veterinary drugs; it is used for the treatment of Gram-positive and Gram-negative bacteria. In the scientific literature, there is no high-performance liquid chromatography (HPLC)-UV method for the simultaneous determination of this combination. The objective of this work is to develop and validate an HPLC method for the determination of this combination. In this regard, a new, simple and efficient reversed-phase HPLC method for simultaneous qualitative and quantitative determination of amoxicillin and enrofloxacin, in an injectable preparation with a mixture of inactive excipients, has been developed and validated...
February 16, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28202348/assessment-of-environmental-risks-to-groundwater-ecosystems-related-to-use-of-veterinary-medicinal-products
#2
Boris Kolar, Antonio Finizio
The current EU guidelines for the environmental risk assessment of veterinary pharmaceutical products (VMPs) in groundwater (GW) suggest an approach based on the comparison between the calculated concentration in GW (PECgw) and a threshold concentration of 0.1 μg/L. The latter is the upper limit of the concentration for pesticides in groundwater in the EU. If the calculated PECgw does not exceed the threshold, then the risk is considered acceptable. It is assumed that the concentration of 0.1 μg/L is by default safe for both humans and exposed GW organisms...
February 12, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28166482/post-exposure-rabies-prophylaxis-in-humans-exposed-to-animals-in-lublin-province-eastern-poland-in-2012-2015-a-retrospective-study
#3
Joanna Krzowska-Firych, Krzysztof Tomasiewicz, Agata Kozøowska
Rabies continues to be one of the most important viral diseases and remains a significant threat to public health across the globe. The post-exposure prophylaxis in humans can effectively prevent death after exposure to a potentially infected animal. In Poland, recommendations for rabies PEP followed the  national guidelines which recommend that people should receive PEP when bitten by an animal suspected to be infected by rabies. PEP in humans  includes cleansing and disinfecting the wound or point of contact, and administering anti-rabies immunization...
February 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28142381/questions-and-challenges-in-the-development-of-mesenchymal-stromal-stem-cell-based-therapies-in-veterinary-medicine
#4
Lax Devireddy, Lynne Boxer, Michael Myers, Mark Skasko, Rudell Screven
he therapeutic potential of stem cells has fascinated those interested in treating diseases in both human and animal subjects. Although the exact mechanism of action and the definitive effectiveness of stem cell therapies remain unclear, animal owner perceptions and a desire for improved treatment options have fueled the interest of clinicians and stakeholders. Standards do not yet exist to define the critical attributes of mesenchymal stem cell (MSC)-based products derived from veterinary species such as the dog, cat, and horse...
January 31, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28117638/analysis-of-lomustine-drug-content-in-fda-approved-and-compounded-lomustine-capsules
#5
Butch KuKanich, Matt Warner, Kevin Hahn
OBJECTIVE To determine the lomustine content (potency) in compounded and FDA-approved lomustine capsules. DESIGN Evaluation study. SAMPLE 2 formulations of lomustine capsules (low dose [7 to 11 mg] and high dose [40 to 48 mg]; 5 capsules/dose/source) from 3 compounders and from 1 manufacturer of FDA-approved capsules. PROCEDURES Lomustine content was measured by use of a validated high-pressure liquid chromatography method. An a priori acceptable range of 90% to 110% of the stated lomustine content was selected on the basis of US Pharmacopeia guidelines...
February 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28107831/high-throughput-untargeted-screening-of-veterinary-drug-residues-and-metabolites-in-tilapia-using-high-resolution-orbitrap-mass-spectrometry
#6
Wei Jia, Xiaogang Chu, James Chang, Perry G Wang, Ying Chen, Feng Zhang
An analytical method was developed and validated for simultaneous analysis of one hundred and thirty-seven veterinary drug residues and metabolites from sixteen different classes in tilapia utilizing an improved fully non-targeted way of data acquisition with fragmentation. The automated on-line extraction procedure was achieved in a simple disposable pipet extraction. Ultrahigh-performance liquid chromatography and electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UHPLC Q-Orbitrap) was used for the separation and detection of all the analytes...
March 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28059057/-open-borders-for-alpine-pastures-the-history-of-the-pacage-franco-suisse
#7
J Schluep
Alpine transhumance and summer grazing of animals on both sides of the French-Swiss border has a long tradition. The Bernese authorities first regulated the movement of animals across the French border in the 18th century due to outbreaks of epidemics. At that time the importation of cattle from the "Franche-Comté" was forbidden, but grazing on the French side of the border remained allowed. The 1912 agreement, relating to grazing on both sides of the border, was used for decades as a guideline to ensure the open communication and close cooperation of the veterinary and customs authorities of both countries with regard to border traffic...
January 2017: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/28055579/guidelines-for-the-direct-detection-of-anaplasma-spp-in-diagnosis-and-epidemiological-studies
#8
Cornelia Silaghi, Ana Sofia Santos, Jacinto Gomes, Iva Christova, Ioana Adriana Matei, Gernot Walder, Ana Domingos, Lesley Bell-Sakyi, Hein Sprong, Friederike D von Loewenich, José A Oteo, José de la Fuente, J Stephen Dumler
The genus Anaplasma (Rickettsiales: Anaplasmataceae) comprises obligate intracellular Gram-negative bacteria that are mainly transmitted by ticks, and currently includes six species: Anaplasma bovis, Anaplasma centrale, Anaplasma marginale, Anaplasma phagocytophilum, Anaplasma platys, and Anaplasma ovis. These have long been known as etiological agents of veterinary diseases that affect domestic and wild animals worldwide. A zoonotic role has been recognized for A. phagocytophilum, but other species can also be pathogenic for humans...
January 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28054393/degenerative-valvular-disease-in-the-cavalier-king-charles-spaniel-results-of-the-uk-breed-scheme-1991-2010
#9
S Swift, A Baldin, P Cripps
BACKGROUND: Cavalier King Charles spaniels (CKCSs) are predisposed to degenerative mitral valve disease (DMVD) and studies have indicated a genetic cause. ANIMALS: A total of 8,860 CKCSs were examined at shows or private clinics from 1991 to 2010. OBJECTIVES: To analyze the effects of a breed scheme for CKCS on the age at which a murmur consistent with DMVD was first detected. METHODS: The presence or absence of a murmur consistent with mitral regurgitation was noted and age a murmur was first detected recorded...
January 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28010905/an-investigation-of-antimicrobial-usage-patterns-by-small-animal-veterinarians-in-south-africa
#10
John K Chipangura, Hayley Eagar, Marcia Kgoete, Darrell Abernethy, Vinny Naidoo
AIM: At present very little information is available on antimicrobial use patterns in small animal veterinary practice in South Africa. The aim of this study was firstly to provide some indication of antimicrobial use patterns, and secondly to ascertain if the country's small animal veterinarians make use of prudent use guidelines to optimise their antimicrobial use in order to minimise the development of antimicrobial resistance. METHODOLOGY: In order to understand use patterns, a questionnaire was circulated to registered South African veterinarians, whose responses were evaluated by descriptive statistics...
January 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27956777/helminth-infections-in-domestic-dogs-from-russia
#11
REVIEW
T V Moskvina, A V Ermolenko
Dogs are the hosts for a wide helminth spectrum including tapeworms, flatworms, and nematodes. These parasites affect the dog health and cause morbidity and mortality, especially in young and old animals. Some species, as Toxocara canis, Ancylostoma caninum, Dipylidium caninum, and Echinococcus spp. are well-known zoonotic parasites worldwide, resulting in high public health risks. Poor data about canine helminth species and prevalence are available in Russia, mainly due to the absence of official guidelines for the control of dog parasites...
November 2016: Veterinary World
https://www.readbyqxmd.com/read/27934622/-antibioticscout-online-tool-for-antimicrobial-stewardship-in-veterinary-medicine
#12
R Peter, C Müntener, D Demuth, D Heim, M Mevissen, G Schüpbach-Regula, S Schuller, F Stucki, B Willi, H Naegeli
Resistances to antimicrobials pose serious public health challenges. This issue concerns both human and veterinary medicine and can only be solved by a multidisciplinary approach. A comprehensive concept is, therefore, being worked out within the StAR (strategy antibiotic resistance) program in order to preserve the effectiveness of antibiotics for humans as well as animals. In this context, the AntibioticScout (www.AntibioticScout. ch) offers a new online tool for the prudent use of antibiotics in veterinary medicine...
December 2016: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/27932337/development-of-a-critical-appraisal-tool-to-assess-the-quality-of-cross-sectional-studies-axis
#13
Martin J Downes, Marnie L Brennan, Hywel C Williams, Rachel S Dean
OBJECTIVES: The aim of this study was to develop a critical appraisal (CA) tool that addressed study design and reporting quality as well as the risk of bias in cross-sectional studies (CSSs). In addition, the aim was to produce a help document to guide the non-expert user through the tool. DESIGN: An initial scoping review of the published literature and key epidemiological texts was undertaken prior to the formation of a Delphi panel to establish key components for a CA tool for CSSs...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27924912/next-generation-systematics-an-innovative-approach-to-resolve-the-structure-of-complex-prokaryotic-taxa
#14
Vartul Sangal, Michael Goodfellow, Amanda L Jones, Edward C Schwalbe, Jochen Blom, Paul A Hoskisson, Iain C Sutcliffe
Prokaryotic systematics provides the fundamental framework for microbiological research but remains a discipline that relies on a labour- and time-intensive polyphasic taxonomic approach, including DNA-DNA hybridization, variation in 16S rRNA gene sequence and phenotypic characteristics. These techniques suffer from poor resolution in distinguishing between closely related species and often result in misclassification and misidentification of strains. Moreover, guidelines are unclear for the delineation of bacterial genera...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27915307/diversity-and-antifungal-drug-susceptibility-of-cryptococcus-isolates-in-thailand
#15
Navaporn Worasilchai, Marut Tangwattanachuleeporn, Kornvalee Meesilpavikkai, Claudia Folba, Mourine Kangogo, Uwe Groß, Michael Weig, Oliver Bader, Ariya Chindamporn
Yeasts of the Cryptococcus species complex are the causative agent of cryptococcosis, especially in human immunodeficiency virus (HIV) positive individuals. Cerebral or disseminated cryptococcosis has a very high mortality rate worldwide, including in Thailand. Additionally, an increasing rate of antifungal drug resistant cryptococcal isolates has been reported in several neighboring countries, complicating therapeutic approaches. To understand the situation of this infection in Thailand, we retrospectively investigated the molecular epidemiology and antifungal drug resistance in a collection of 74 clinical, 52 environmental and two veterinary isolates using the URA5-RFLP for typing and the EUCAST guideline for susceptibility testing...
December 3, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27891118/colistin-in-pig-production-chemistry-mechanism-of-antibacterial-action-microbial-resistance-emergence-and-one-health-perspectives
#16
REVIEW
Mohamed Rhouma, Francis Beaudry, William Thériault, Ann Letellier
Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in both human and veterinary medicine. For several years now, colistin has been considered the last line of defense against infections caused by multidrug-resistant Gram-negative such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Colistin has been extensively used orally since the 1960s in food animals and particularly in swine for the control of Enterobacteriaceae infections. However, with the recent discovery of plasmid-mediated colistin resistance encoded by the mcr-1 gene and the higher prevalence of samples harboring this gene in animal isolates compared to other origins, livestock has been singled out as the principal reservoir for colistin resistance amplification and spread...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27886775/a-simple-fast-and-sensitive-screening-lc-esi-ms-ms-method-for-antibiotics-in-fish
#17
Letícia Rocha Guidi, Flávio Alves Santos, Ana Cláudia S R Ribeiro, Christian Fernandes, Luiza H M Silva, Maria Beatriz A Gloria
The objective of this study was to develop and validate a fast, sensitive and simple liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method for the screening of six classes of antibiotics (aminoglycosides, beta-lactams, macrolides, quinolones, sulfonamides and tetracyclines) in fish. Samples were extracted with trichloroacetic acid. LC separation was achieved on a Zorbax Eclipse XDB C18 column and gradient elution using 0.1% heptafluorobutyric acid in water and acetonitrile as mobile phase...
January 15, 2017: Talanta
https://www.readbyqxmd.com/read/27873478/methods-and-processes-of-developing-the-strengthening-the-reporting-of-observational-studies-in-epidemiology-veterinary-strobe-vet-statement
#18
J M Sargeant, A M O'Connor, I R Dohoo, H N Erb, M Cevallos, M Egger, A K Ersbøll, S W Martin, L R Nielsen, D L Pearl, D U Pfeiffer, J Sanchez, M E Torrence, H Vigre, C Waldner, M P Ward
The reporting of observational studies in veterinary research presents many challenges that often are not adequately addressed in published reporting guidelines. A consensus meeting of experts was organized to develop an extension of the STROBE statement to address observational studies in veterinary medicine with respect to animal health, animal production, animal welfare and food safety outcomes. The consensus meeting was held 11-13 May 2014 in Mississauga, Ontario, Canada. Seventeen experts from North America, Europe and Australia attended the meeting...
November 22, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27859753/methods-and-processes-of-developing-the-strengthening-the-reporting-of-observational-studies-in-epidemiology-veterinary-strobe-vet-statement
#19
J M Sargeant, A M O'Connor, I R Dohoo, H N Erb, M Cevallos, M Egger, A K Ersbøll, S W Martin, L R Nielsen, D L Pearl, D U Pfeiffer, J Sanchez, M E Torrence, H Vigre, C Waldner, M P Ward
BACKGROUND: Reporting of observational studies in veterinary research presents challenges that often are not addressed in published reporting guidelines. OBJECTIVE: To develop an extension of the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement that addresses unique reporting requirements for observational studies in veterinary medicine related to health, production, welfare, and food safety. DESIGN: Consensus meeting of experts...
November 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27836042/methods-and-processes-of-developing-the-strengthening-the-reporting-of-observational-studies-in-epidemiology-veterinary-strobe-vet-statement
#20
J M Sargeant, A M O'Connor, I R Dohoo, H N Erb, M Cevallos, M Egger, A K Ersbøll, S W Martin, L R Nielsen, D L Pearl, D U Pfeiffer, J Sanchez, M E Torrence, H Vigre, C Waldner, M P Ward
BACKGROUND: The reporting of observational studies in veterinary research presents many challenges that often are not adequately addressed in published reporting guidelines. OBJECTIVE: To develop an extension of the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement that addresses unique reporting requirements for observational studies in veterinary medicine related to health, production, welfare, and food safety. DESIGN: A consensus meeting of experts was organized to develop an extension of the STROBE statement to address observational studies in veterinary medicine with respect to animal health, animal production, animal welfare, and food safety outcomes...
November 1, 2016: Preventive Veterinary Medicine
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