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Li-ESWT

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https://www.readbyqxmd.com/read/28884638/low-intensity-extracorporeal-shockwave-therapy-can-improve-erectile-function-in-patients-who-failed-to-respond-to-phosphodiesterase-type-5-inhibitors
#1
Chia-Chun Tsai, Chii-Jye Wang, Yung-Chin Lee, Yen-Ting Kuo, Hsiao-Hua Lin, Ching-Chia Li, Wen-Jeng Wu, Chia-Chu Liu
Managing patients with erectile dysfunction (ED) who failed to respond to phosphodiesterase type 5 inhibitors (PDE5is) is a challenging task. Recently, low-intensity extracorporeal shockwave therapy (LI-ESWT) was reported to improve ED by enhancing perfusion of the penis. The current study was performed to evaluate whether combined treatment with LI-ESWT and PDE5is can restore erectile function in patients who failed to respond to PDE5is alone. This was an open-label single-arm prospective study. ED patients with an erection hardness score (EHS) ≦2 under a maximal dosage of PDE5is were enrolled...
September 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28763567/low-intensity-extracorporeal-shock-wave-therapy-promotes-myogenesis-through-perk-atf4-pathway
#2
Bohan Wang, Jun Zhou, Lia Banie, Amanda B Reed-Maldonado, Hongxiu Ning, Zhihua Lu, Yajun Ruan, Tie Zhou, Hsun Shuan Wang, Byung Seok Oh, Guifang Wang, Stanley Lei Qi, Guiting Lin, Tom F Lue
AIM: Stress urinary incontinence (SUI) is a significant health problem for women. Treatments employing muscle derived stem cells (MDSCs) may be a promising approach to this prevalent, bothersome condition, but these treatments are invasive and require collection of cells from one site for injection into another. It is also unknown whether or not these cells establish themselves and function as muscle cells in the target tissues. Alternatively, low-intensity extracorporeal shock wave therapy (Li-ESWT) is non-invasive and has shown positive outcomes in the treatment of multiple musculoskeletal disorders, but the biological effects responsible for clinical success are not yet well understood...
August 1, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28741629/low-intensity-shockwave-therapy-for-erectile-dysfunction-is-the-evidence-strong-enough
#3
REVIEW
(no author information available yet)
Erectile dysfunction (ED) affects ∼30% of all men above the age of 40 years and its prevalence steadily increases with age. Current nonsurgical treatment options, including phosphodiesterase type 5 inhibitors (PDE5I), provide temporary relief but have failed to provide a permanent improvement of the condition. Low-intensity extracorporeal shockwave therapy (Li-ESWT) is noninvasive and uses acoustic waves, which can pass through tissue and be focussed to target specific areas or organs to induce the desired effects...
July 25, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28673433/low-intensity-shockwave-therapy-improves-hemodynamic-parameters-in-patients-with-vasculogenic-erectile-dysfunction-a-triplex-ultrasonography-based-sham-controlled-trial
#4
Dimitrios Kalyvianakis, Dimitrios Hatzichristou
BACKGROUND: Although several reports have documented the subjective improvement of erectile function after low-intensity extracorporeal shockwave therapy (LI-ESWT) in patients with vasculogenic erectile dysfunction (ED), objective assessment data of penile hemodynamics are lacking. AIM: To assess penile hemodynamics before and 3 months after LI-ESWT in a group of patients with documented vasculogenic ED. METHODS: This was a double-blinded, randomized, sham-controlled trial...
July 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28379665/short-term-efficacy-and-safety-of-low-intensity-extracorporeal-shock-wave-therapy-in-erectile-dysfunction-a-systematic-review-and-meta-analysis
#5
Zi-Jun Zou, Liang-You Tang, Zhi-Hong Liu, Jia-Yu Liang, Ruo-Chen Zhang, Yu-Jie Wang, Yong-Quan Tang, Rui Gao, Yi-Ping Lu
AIM: The role of low-intensity extracorporeal shock wave therapy (LI-ESWT) in erectile dysfunction (ED) is not clearly determined. The purpose of this study is to investigate the short-term efficacy and safety of LI-ESWT for ED patients. MATERIALS AND METHODS: Relevant studies were searched in Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), WANFANG and VIP databases. Effective rate in terms of International Index of Erectile Function-Erectile Function Domain (IIEF-EF) and Erectile Hardness Score (EHS) at about 1month after LI-ESWT was extracted from eligible studies for meta-analysis to calculate risk ratio (RR) of effective treatment in ED patients treated by LI-ESWT compared to those receiving sham-treatment...
April 6, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28268167/low-intensity-extracorporeal-shockwave-therapy-in-sexual-medicine-a%C3%A2-questionnaire-based-assessment-of-knowledge-clinical-practice-patterns-and-attitudes-in-sexual-medicine-practitioners
#6
Mikkel Fode, Lior Lowenstein, Yacov Reisman
INTRODUCTION: Low-intensity extracorporeal shockwave therapy (LI-ESWT) has emerged as a treatment option for male sexual dysfunction. However, results have been contradictory. AIM: To investigate the knowledge, practice patterns, and attitudes regarding LI-ESWT among experts in sexual medicine. METHODS: A study-specific questionnaire was handed out at the 18th Congress for the European Society for Sexual Medicine. Participants were queried on their knowledge about LI-ESWT and about their use of the equipment...
June 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28258952/in-situ-activation-of-penile-progenitor-cells-with-low-intensity-extracorporeal-shockwave-therapy
#7
Guiting Lin, Amanda B Reed-Maldonado, Bohan Wang, Yung-Chin Lee, Jun Zhou, Zhihua Lu, Guifang Wang, Lia Banie, Tom F Lue
BACKGROUND: We previously reported that progenitor cells, or stem cells, exist within penile tissue. We hypothesized that acoustic wave stimulation by low-intensity extracorporeal shockwave therapy (Li-ESWT) would activate local stem or progenitor cells within the penis, producing regenerative effects. AIMS: To study the feasibility of in situ penile progenitor cell activation by Li-ESWT. METHODS: We performed a cohort analysis of young and middle-age male Sprague-Dawley rats treated with 5-ethynyl-2'-deoxyuridine (EdU) pulse followed by Li-ESWT...
April 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28212323/low-intensity-extracorporeal-shock-wave-therapy-enhances-brain-derived-neurotrophic-factor-expression-through-perk-atf4-signaling-pathway
#8
Bohan Wang, Hongxiu Ning, Amanda B Reed-Maldonado, Jun Zhou, Yajun Ruan, Tie Zhou, Hsun Shuan Wang, Byung Seok Oh, Lia Banie, Guiting Lin, Tom F Lue
Low-intensity extracorporeal shock wave therapy (Li-ESWT) is used in the treatment of erectile dysfunction, but its mechanisms are not well understood. Previously, we found that Li-ESWT increased the expression of brain-derived neurotrophic factor (BDNF). Here we assessed the underlying signaling pathways in Schwann cells in vitro and in penis tissue in vivo after nerve injury. The result indicated that BDNF were significantly increased by the Li-ESWT after nerve injury, as well as the expression of BDNF in Schwann cells (SCs, RT4-D6P2T) in vitro...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27986492/effects-of-low-intensity-extracorporeal-shockwave-therapy-on-erectile-dysfunction-a-systematic-review-and-meta-analysis
#9
REVIEW
Raul I Clavijo, Taylor P Kohn, Jaden R Kohn, Ranjith Ramasamy
INTRODUCTION: Low-intensity extracorporeal shock wave therapy (Li-ESWT) has been proposed as an effective non-invasive treatment option for erectile dysfunction (ED). AIM: To use systematic review and meta-analysis to assess the efficacy of Li-ESWT by comparing change in erectile function as assessed by the erectile function domain of the International Index of Erectile Function (IIEF-EF) in men undergoing Li-ESWT vs sham therapy for the treatment of ED. METHODS: Systematic search was conducted of MEDLINE, EMBASE, and ClinicalTrials...
January 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27938990/effect-of-low-energy-linear-shockwave-therapy-on-erectile-dysfunction-a-double-blinded-sham-controlled-randomized-clinical%C3%A2-trial
#10
RANDOMIZED CONTROLLED TRIAL
Grzegorz L Fojecki, Stefan Tiessen, Palle J S Osther
INTRODUCTION: Previous studies have shown that focal low-energy extracorporeal shockwave therapy (Li-ESWT) can have a positive effect in men with erectile dysfunction (ED). Linear Li-ESWT (LLi-ESWT) for ED has not been previously assessed in a randomized trial. AIM: To evaluate the treatment outcome of LLi-ESWT for ED. METHODS: Men with ED (n = 126) and a score lower than 25 points on the International Index of Erectile Function erectile function domain (IIEF-EF) were included...
January 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27402058/low-intensity-extracorporeal-shock-waves-therapy-li-eswt-for-the-treatment-of-erectile-dysfunction-where-do-we-stand
#11
EDITORIAL
Dimitris Hatzichristou
No abstract text is available yet for this article.
February 2017: European Urology
https://www.readbyqxmd.com/read/27321373/low-intensity-extracorporeal-shock-wave-treatment-improves-erectile-function-a-systematic-review-and-meta-analysis
#12
REVIEW
Zhihua Lu, Guiting Lin, Amanda Reed-Maldonado, Chunxi Wang, Yung-Chin Lee, Tom F Lue
CONTEXT: As a novel therapeutic method for erectile dysfunction (ED), low-intensity extracorporeal shock wave treatment (LI-ESWT) has been applied recently in the clinical setting. We feel that a summary of the current literature and a systematic review to evaluate the therapeutic efficacy of LI-ESWT for ED would be helpful for physicians who are interested in using this modality to treat patients with ED. OBJECTIVE: A systematic review of the evidence regarding LI-ESWT for patients with ED was undertaken with a meta-analysis to identify the efficacy of the treatment modality...
February 2017: European Urology
https://www.readbyqxmd.com/read/27038770/low-intensity-extracorporeal-shock-wave-therapy-improves-erectile-function-in-a-model-of-type-ii-diabetes-independently-of-no-cgmp-pathway
#13
Rana Assaly-Kaddoum, François Giuliano, Miguel Laurin, Diane Gorny, Micheline Kergoat, Jacques Bernabé, Yoram Vardi, Laurent Alexandre, Delphine Behr-Roussel
PURPOSE: Erectile dysfunction is highly prevalent in type II diabetes mellitus. Low intensity extracorporeal shock wave therapy improves erectile function in patients with erectile dysfunction of vasculogenic origin, including diabetes. However, its mode of action remains unknown. We investigated the effects of low intensity extracorporeal shock wave therapy compared to or combined with sildenafil on erectile dysfunction in a type II diabetes mellitus model. Our purpose was to test our hypothesis of a mode of action targeting the cavernous nitric oxide/cyclic guanosine monophosphate pathway...
September 2016: Journal of Urology
https://www.readbyqxmd.com/read/26493542/low-intensity-extracorporeal-shockwave-therapy-in-the-treatment-of-postprostatectomy-erectile-dysfunction-a-pilot-study
#14
Anders Frey, Jens Sønksen, Mikkel Fode
OBJECTIVE: The objective was to investigate the effect and feasibility of low-intensity extracorporeal shockwave therapy (LI-ESWT) as a treatment for erectile dysfunction (ED) after bilateral nerve-sparing radical prostatectomy (RP). MATERIALS AND METHODS: Patients who had undergone robot-assisted bilateral nerve-sparing RP more than a year before entering this pilot study, had no preoperative ED and were suffering from mild to severe postoperative ED were invited to participate...
2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/25694008/low-intensity-extracorporeal-shockwave-therapy-for-erectile-dysfunction-a-study-in-an-indian-population
#15
RANDOMIZED CONTROLLED TRIAL
Vasan Satya Srini, Rahul Kumar Reddy, Tamar Shultz, Bela Denes
INTRODUCTION: Erectile dysfunction (ED) has been shown to be associated with a number of physical conditions and affects not only physical but also psychosocial health. Currently oral, on-demand phosphodiesterase type 5 inhibitors (PDE5i) are preferred first line treatment. Though effective, these drugs have limitations and are associated with significant non-compliance, side effects and do not reverse the underlying pathology. Non-invasive low intensity shockwave therapy (LISWT) has been shown to significantly improve erectile function in men previously PDE5i dependent...
February 2015: Canadian Journal of Urology
https://www.readbyqxmd.com/read/25470423/can-low-intensity-extracorporeal-shockwave-therapy-improve-erectile-dysfunction-a-prospective-randomized-double-blind-placebo-controlled-study
#16
RANDOMIZED CONTROLLED TRIAL
Anne B Olsen, Marie Persiani, Sidsel Boie, Milad Hanna, Lars Lund
OBJECTIVE: The aim of this study was to investigate whether low-intensity extracorporeal shockwave therapy (LI-ESWT) can be used as a treatment for men with erectile dysfunction of organic origin. MATERIALS AND METHODS: This prospective, randomized, blinded, placebo-controlled study included 112 men unable to have intercourse either with or without medication. Erectile dysfunction was assessed at screening and 5, 12 and 24 weeks after treatment. Assessment was performed by interview and using the Erection Hardness Scale (EHS) and the International Index of Erectile Function (IIEF-15) questionnaire...
2015: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/23554844/shockwave-treatment-of-erectile-dysfunction
#17
Ilan Gruenwald, Boaz Appel, Noam D Kitrey, Yoram Vardi
Low-intensity extracorporeal shock wave therapy (LI-ESWT) is a novel modality that has recently been developed for treating erectile dysfunction (ED). Unlike other current treatment options for ED, all of which are palliative in nature, LI-ESWT is unique in that it aims to restore the erectile mechanism in order to enable natural or spontaneous erections. Results from basic science experiments have provided evidence that LI-ESWT induces cellular microtrauma, which in turn stimulates the release of angiogenic factors and the subsequent neovascularization of the treated tissue...
April 2013: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/22008059/low-intensity-extracorporeal-shock-wave-therapy-a-novel-effective-treatment-for-erectile-dysfunction-in-severe-ed-patients-who-respond-poorly-to-pde5-inhibitor-therapy
#18
Ilan Gruenwald, Boaz Appel, Yoram Vardi
INTRODUCTION: Low-intensity shock wave therapy (LI-ESWT) has been reported as an effective treatment in men with mild and moderate erectile dysfunction (ED). AIM: The aim of this study is to determine the efficacy of LI-ESWT in severe ED patients who were poor responders to phosphodiesterase type 5 inhibitor (PDE5i) therapy. METHODS: This was an open-label single-arm prospective study on ED patients with an erection hardness score (EHS) ≤ 2 at baseline...
January 2012: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/20451317/can-low-intensity-extracorporeal-shockwave-therapy-improve-erectile-function-a-6-month-follow-up-pilot-study-in-patients-with-organic-erectile-dysfunction
#19
Yoram Vardi, Boaz Appel, Giris Jacob, Omar Massarwi, Ilan Gruenwald
BACKGROUND: Low-intensity extracorporeal shockwave therapy (LI-ESWT) is currently under investigation regarding its ability to promote neovascularization in different organs. OBJECTIVE: To evaluate the effect of LI-ESWT on men with erectile dysfunction (ED) who have previously responded to oral phosphodiesterase type 5 inhibitors (PDE5-I). DESIGN, SETTING, AND PARTICIPANTS: We screened 20 men with vasculogenic ED who had International Index of Erectile Function ED (IIEF-ED) domain scores between 5-19 (average: 13...
August 2010: European Urology
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