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Andersson B. S.

H Lindman, M Andersson, J Ahlgren, E Balslev, A Sverrisdottir, S B Holmberg, N O Bengtsson, E H Jacobsen, A B Jensen, J Hansen, M K Tuxen, L Malmberg, K Villman, H Anderson, B Ejlertsen, J Bergh, C Blomqvist
STUDY AIM: Retrospective studies have demonstrated a worse outcome in breast cancer patients not developing leukopenia during adjuvant chemotherapy. The SBG 2000-1 is the first randomised trial designed to compare individually dosed chemotherapy without G-CSF support based on grade of toxicity to standard-dosed chemotherapy based on body surface area (BSA). METHODS: Patients with early breast cancer were included and received the first cycle of standard FEC (fluorouracil 600 mg/m2 , epirubicin 60 mg/m2 , cyclophosphamide 600 mg/m2 )...
March 13, 2018: European Journal of Cancer
Peter Nash, Philip J Mease, Iain B McInnes, Proton Rahman, Christopher T Ritchlin, Ricardo Blanco, Eva Dokoupilova, Mats Andersson, Radhika Kajekar, Shephard Mpofu, Luminita Pricop
BACKGROUND: The study aimed to assess 52-week efficacy and safety of secukinumab self-administration by autoinjector in patients with active psoriatic arthritis (PsA) in the FUTURE 3 study ( NCT01989468). METHODS: Patients (≥ 18 years of age; N = 414) with active PsA were randomized 1:1:1 to subcutaneous (s.c.) secukinumab 300 mg, 150 mg, or placebo at baseline, weeks 1, 2, 3, and 4, and every 4 weeks thereafter. Per clinical response, placebo-treated patients were re-randomized to s...
March 15, 2018: Arthritis Research & Therapy
Nikos Schizas, N König, B Andersson, S Vasylovska, J Hoeber, E N Kozlova, N P Hailer
The acute phase of spinal cord injury is characterized by excitotoxic and inflammatory events that mediate extensive neuronal loss in the gray matter. Neural crest stem cells (NCSCs) can exert neuroprotective and anti-inflammatory effects that may be mediated by soluble factors. We therefore hypothesize that transplantation of NCSCs to acutely injured spinal cord slice cultures (SCSCs) can prevent neuronal loss after excitotoxic injury. NCSCs were applied onto SCSCs previously subjected to N-methyl-D-aspartate (NMDA)-induced injury...
March 7, 2018: Cell and Tissue Research
Allison J Kwong, Matthew S Chang, Ruth E Tuomala, Laura E Riley, Julian N Robinson, Muthoka L Mutinga, Karin L Andersson, Robert S Brown, Emily Oken, Chinweike Ukomadu, Anna E Rutherford
Objectives Hepatitis B (HBV) remains a significant public health burden, despite effective therapy. Routine HBV screening is recommended during pregnancy to reduce the risk of vertical transmission, but the rates of follow-up care peri-partum are low. The aim of this study was to evaluate physician practices and knowledge regarding HBV in women diagnosed perinatally. Methods A survey was distributed to obstetricians and midwives within the Partners HealthCare system at Brigham and Women's Hospital and Massachusetts General Hospital...
March 6, 2018: Maternal and Child Health Journal
Yago Nieto, Peter F Thall, Junsheng Ma, Benigno C Valdez, Sairah Ahmed, Paolo Anderlini, Uday Popat, Roy B Jones, Elizabeth J Shpall, Chitra Hosing, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Melissa Timmons, Alison Gulbis, Alan Myers, Yasuhiro Oki, Michelle Fanale, Bouthaina Dabaja, Chelsea Pinnix, Sarah Milgrom, Richard Champlin, Borje S Andersson
We conducted a prospective phase 2 trial of gemcitabine, busulfan and melphalan (Gem/Bu/Mel) with autologous stem-cell transplantation (ASCT) in Hodgkin's lymphoma (HL) patients with primary refractory or poor-risk relapsed disease (extranodal relapse or within 1 year of frontline therapy). The trial was powered to detect a 2-year progression-free survival (PFS) rate improvement from a historical 50% (using BEAM) to 65%. We compared the study population with all other concurrent patients who were eligible for the trial but instead received BEAM at our center...
March 1, 2018: Biology of Blood and Marrow Transplantation
J Kenneth Baillie, Andrew Bretherick, Christopher S Haley, Sara Clohisey, Alan Gray, Lucile P A Neyton, Jeffrey Barrett, Eli A Stahl, Albert Tenesa, Robin Andersson, J Ben Brown, Geoffrey J Faulkner, Marina Lizio, Ulf Schaefer, Carsten Daub, Masayoshi Itoh, Naoto Kondo, Timo Lassmann, Jun Kawai, Damian Mole, Vladimir B Bajic, Peter Heutink, Michael Rehli, Hideya Kawaji, Albin Sandelin, Harukazu Suzuki, Jack Satsangi, Christine A Wells, Nir Hacohen, Thomas C Freeman, Yoshihide Hayashizaki, Piero Carninci, Alistair R R Forrest, David A Hume
Genetic variants underlying complex traits, including disease susceptibility, are enriched within the transcriptional regulatory elements, promoters and enhancers. There is emerging evidence that regulatory elements associated with particular traits or diseases share similar patterns of transcriptional activity. Accordingly, shared transcriptional activity (coexpression) may help prioritise loci associated with a given trait, and help to identify underlying biological processes. Using cap analysis of gene expression (CAGE) profiles of promoter- and enhancer-derived RNAs across 1824 human samples, we have analysed coexpression of RNAs originating from trait-associated regulatory regions using a novel quantitative method (network density analysis; NDA)...
March 1, 2018: PLoS Computational Biology
A Schrader, G Crispatzu, S Oberbeck, P Mayer, S Pützer, J von Jan, E Vasyutina, K Warner, N Weit, N Pflug, T Braun, E I Andersson, B Yadav, A Riabinska, B Maurer, M S Ventura Ferreira, F Beier, J Altmüller, M Lanasa, C D Herling, T Haferlach, S Stilgenbauer, G Hopfinger, M Peifer, T H Brümmendorf, P Nürnberg, K S J Elenitoba-Johnson, S Zha, M Hallek, R Moriggl, H C Reinhardt, M-H Stern, S Mustjoki, S Newrzela, P Frommolt, M Herling
T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nucleotide sequences in 111 well-characterized patients. Besides prominent signatures of T-cell activation and prevalent clonal variants, we also identify novel hot-spots for CN variability, fusion molecules, alternative transcripts, and progression-associated dynamics. The overall lesional spectrum of T-PLL is mainly annotated to axes of DNA damage responses, T-cell receptor/cytokine signaling, and histone modulation...
February 15, 2018: Nature Communications
C G Clemmesen, L M Pedersen, S Hougaard, M L Andersson, V Rosenkvist, H B Nielsen, H Palm, N B Foss
This study explores the association between postadmission and intraoperative cerebral oxygenation (ScO2), reflecting systemic perfusion, and postoperative mortality and delirium. Forty elderly (age > 65 years) patients with hip fractures were included in this prospective observational study. The ScO2 was determined using near-infrared spectroscopy at initial resuscitation after patients were admitted to the hospital and during surgery. Postoperative delirium was assessed up to seven days after surgery using the memorial delirium assessment scale and the confusion assessment method...
February 5, 2018: Journal of Clinical Monitoring and Computing
Tea Soini, Marjut Pihlajoki, Noora Andersson, Jouko Lohi, Kari A Huppert, David A Rudnick, Stacey S Huppert, David B Wilson, Mikko P Pakarinen, Markku Heikinheimo
Biliary atresia (BA), a neonatal liver disease, is characterized by obstruction of extrahepatic bile ducts with subsequent cholestasis, inflammation, and progressive liver fibrosis. To gain insights into the pathophysiology of BA, we focused attention on GATA6, a transcription factor implicated in biliary development. Early in fetal development GATA6 expression is evident in cholangiocytes and hepatocytes, but by late gestation it is extinguished in hepatocytes. Utilizing a unique set of BA liver samples collected before and after successful portoenterostomy (PE), we found that GATA6 expression is markedly upregulated in hepatocytes of patients with BA compared to healthy and cholestatic disease controls...
February 1, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
Sean D Schoville, Yolanda H Chen, Martin N Andersson, Joshua B Benoit, Anita Bhandari, Julia H Bowsher, Kristian Brevik, Kaat Cappelle, Mei-Ju M Chen, Anna K Childers, Christopher Childers, Olivier Christiaens, Justin Clements, Elise M Didion, Elena N Elpidina, Patamarerk Engsontia, Markus Friedrich, Inmaculada García-Robles, Richard A Gibbs, Chandan Goswami, Alessandro Grapputo, Kristina Gruden, Marcin Grynberg, Bernard Henrissat, Emily C Jennings, Jeffery W Jones, Megha Kalsi, Sher A Khan, Abhishek Kumar, Fei Li, Vincent Lombard, Xingzhou Ma, Alexander Martynov, Nicholas J Miller, Robert F Mitchell, Monica Munoz-Torres, Anna Muszewska, Brenda Oppert, Subba Reddy Palli, Kristen A Panfilio, Yannick Pauchet, Lindsey C Perkin, Marko Petek, Monica F Poelchau, Éric Record, Joseph P Rinehart, Hugh M Robertson, Andrew J Rosendale, Victor M Ruiz-Arroyo, Guy Smagghe, Zsofia Szendrei, Gregg W C Thomas, Alex S Torson, Iris M Vargas Jentzsch, Matthew T Weirauch, Ashley D Yates, George D Yocum, June-Sun Yoon, Stephen Richards
The Colorado potato beetle is one of the most challenging agricultural pests to manage. It has shown a spectacular ability to adapt to a variety of solanaceaeous plants and variable climates during its global invasion, and, notably, to rapidly evolve insecticide resistance. To examine evidence of rapid evolutionary change, and to understand the genetic basis of herbivory and insecticide resistance, we tested for structural and functional genomic changes relative to other arthropod species using genome sequencing, transcriptomics, and community annotation...
January 31, 2018: Scientific Reports
Betül Oran, Rima M Saliba, Yudith Carmazzi, Marcos de Lima, Gabriela Rondon, Sairah Ahmed, Amin Alousi, Borje S Andersson, Paolo Anderlini, Michelle Alvarez, Qasier Bashir, Stefan Ciurea, Marcelo Fernandez-Vina, Chitra Hosing, Partow Kebriaei, Martin Korbling, Pedro Cano, Issa Khouri, David Marin, Yago Nieto, Amanda Olson, Uday Popat, Katy Rezvani, Muzaffar Qazilbash, Elizabeth J Shpall, Richard E Champlin, Kai Cao
We investigated the impact of donor-recipient HLA-DPB1 matching on outcomes of allogeneic hematopoietic stem cell transplantation with in vivo T cell depletion using ATG for patients with hematological malignancies. All donor-recipient pairs had high resolution typing for HLA-A, -B, -C, -DRB1, -DQB1, -DPB1 and -DRB3/4/5 and were matched at HLA-A, -B, -C and -DRB1. HLA-DPB1 mismatches were categorized by immunogenicity of the DPB1 matching using the DPB T-cell epitope tool. Of 1004 donor-recipient pairs, 210 (21%) were DPB1 matched, 443 (44%) had permissive mismatches, 184 (18%) non-permissive mismatches, in graft versus host (GvH) direction and 167 (17%) non-permissive mismatches in host versus graft (HvG) direction...
January 31, 2018: Blood
K Binzel, A Adelaja, C L Wright, D Scharre, J Zhang, M V Knopp, E J Teoh, D Bottomley, A Scarsbrook, H Payne, A Afaq, J Bomanji, N van As, S Chua, P Hoskin, A Chambers, G J Cook, V S Warbey, A Chau, P Ward, M P Miller, D J Stevens, L Wilson, F V Gleeson, K Scheidhauer, C Seidl, M Autenrieth, F Bruchertseifer, C Apostolidis, F Kurtz, T Horn, C Pfob, M Schwaiger, J Gschwend, C D'Alessandria, A Morgenstern, C Uprimny, A Kroiss, C Decristoforo, E von Guggenberg, B Nilica, W Horninger, I Virgolini, S Rasul, N Poetsch, A Woehrer, M Preusser, M Mitterhauser, W Wadsak, G Widhalm, M Mischkulnig, M Hacker, T Traub-Weidinger, C L Wright, K Binzel, E J Wuthrick, E D Miller, P Maniawski, J Zhang, M V Knopp, Sebastijan Rep, Marko Hocevar, Janja Vaupotic, Urban Zdesar, Katja Zaletel, Luka Lezaic, S Mairinger, Thomas Filip, M Sauberer, S Flunkert, T Wanek, J Stanek, N Okamura, O Langer, C Kuntner, M C Fornito, R Balzano, V Di Martino, S Cacciaguerra, G Russo, D Seifert, M Kleinova, A Cepa, J Ralis, P Hanc, O Lebeda, M Mosa, S Vandenberghe, E Mikhaylova, D Borys, V Viswanath, M Stockhoff, N Efthimiou, P Caribe, R Van Holen, J S Karp, K Binzel, J Zhang, C L Wright, P Maniawski, M V Knopp, P M Haller, C Farhan, E Piackova, B Jäger, P Knoll, A Kiss, B K Podesser, J Wojta, K Huber, S Mirzaei, A Traxl, K Komposch, Elisabeth Glitzner, T Wanek, S Mairinger, M Sibilia, O Langer, M C Fornito, M Russello, G Russo, R Balzano, S Sorko, H J Gallowitsch, S Kohlfuerst, S Matschnig, M Rieser, M Sorschag, P Lind, L Ležaič, S Rep, J Žibert, N Frelih, S Šuštar, K Binzel, A Adelaja, C L Wright, D Scharre, J Zhang, M V Knopp, R P Baum, T Langbein, A Singh, M Shahinfar, C Schuchardt, G F Volk, H R Kulkarni, M C Fornito, S Cacciaguerra, R Balzano, G V Di Martino, G Russo, W H Thomson, M Kudlacek, M Karik, C Farhan, H Rieger, W Pokieser, K Glaser, S Mirzaei, V Petz, C Tugendsam, W Buchinger, B Schmoll-Hauer, I P Schenk, K Rudolph, M Krebs, G Zettinig, V Zoufal, T Wanek, M Krohn, S Mairinger, J Stanek, M Sauberer, T Filip, J Pahnke, O Langer, F Weitzer, B Pernthaler, S Salamon, R Aigner, P Koranda, L Henzlová, M Kamínek, Mo Váchalová, P Bachleda, D Summer, J Garousi, M Oroujeni, B Mitran, K G Andersson, A Vorobyeva, J N Löfblom, A Orlova, V Tolmachev, C Decristoforo, P Kaeopookum, D Summer, T Orasch, B Lechner, M Petrik, Z Novy, C Rangger, H Haas, C Decristoforo
No abstract text is available yet for this article.
January 23, 2018: EJNMMI Research
Roni Tamari, Betul Oran, Patrick Hilden, Molly Maloy, Piyanuch Kongtim, Esperanza B Papadopoulos, Gabriela Rondon, Ann A Jakubowski, Borje S Andersson, Sean M Devlin, Sairah Ahmed, Uday R Popat, Doris Ponce, Julianne Chen, Craig Sauter, James W Young, Marcos de Lima, Miguel-Angel Perales, Richard J O'Reilly, Sergio A Giralt, Richard E Champlin, Hugo Castro-Malaspina
PURPOSE: To compare transplant outcomes in patients with advanced myelodysplastic syndrome (MDS) after CD34+ selected or unmodified allografts. PATIENTS AND METHODS: This analysis included initially 181 patients; 60 underwent CD34+ selected transplant and 121 had an unmodified transplant. Due to significant differences in disease characteristics, the analysis was limited to patients who had <10% blasts prior to transplant (N=145). Two groups were defined: (1) low risk: good and intermediate risk cytogenetics (CD34+, N=39; unmodified, N=46), and (2) high risk: poor and very poor risk cytogenetic (CD34+, N=19; unmodified, N=41)...
January 8, 2018: Biology of Blood and Marrow Transplantation
Kasper Almholt, Josephine B Hebsgaard, Anneline Nansen, Christina Andersson, Jesper Pass, Birgitte Rønø, Peter Thygesen, Hermann Pelzer, Mette Loftager, Ida K Lund, Gunilla Høyer-Hansen, Thomas Frisch, Claus H Jensen, Kristian S Otte, Niels H Søe, Else M Bartels, Martin Andersen, Henning Bliddal, Pernille A Usher
Genetic absence of the urokinase-type plasminogen activator (uPA) reduces arthritis progression in the collagen-induced arthritis (CIA) mouse model to an extent just shy of disease abrogation, but this remarkable observation has not been translated into therapeutic intervention. Our aim was to test the potential in mice of an Ab that blocks the proteolytic capacity of uPA in the CIA model and the delayed-type hypersensitivity arthritis model. A second aim was to determine the cellular origins of uPA and the uPA receptor (uPAR) in joint tissue from patients with rheumatoid arthritis...
December 27, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
Sascha Dietrich, Małgorzata Oleś, Junyan Lu, Leopold Sellner, Simon Anders, Britta Velten, Bian Wu, Jennifer Hüllein, Michelle da Silva Liberio, Tatjana Walther, Lena Wagner, Sophie Rabe, Sonja Ghidelli-Disse, Marcus Bantscheff, Andrzej K Oleś, Mikołaj Słabicki, Andreas Mock, Christopher C Oakes, Shihui Wang, Sina Oppermann, Marina Lukas, Vladislav Kim, Martin Sill, Axel Benner, Anna Jauch, Lesley Ann Sutton, Emma Young, Richard Rosenquist, Xiyang Liu, Alexander Jethwa, Kwang Seok Lee, Joe Lewis, Kerstin Putzker, Christoph Lutz, Davide Rossi, Andriy Mokhir, Thomas Oellerich, Katja Zirlik, Marco Herling, Florence Nguyen-Khac, Christoph Plass, Emma Andersson, Satu Mustjoki, Christof von Kalle, Anthony D Ho, Manfred Hensel, Jan Dürig, Ingo Ringshausen, Marc Zapatka, Wolfgang Huber, Thorsten Zenz
As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongside genome, transcriptome, and DNA methylome analysis to understand determinants of drug response. We assembled a primary blood cancer cell encyclopedia data set that revealed disease-specific sensitivities for each cancer...
January 2, 2018: Journal of Clinical Investigation
Shu-Hua Yang, Alejandro A Espinoza Orías, Chien-Chou Pan, Issei Senoo, Gunnar B J Andersson, Howard S An, Nozomu Inoue
BACKGROUND: With advancing stages of degeneration, denaturation and degradation of proteoglycans in the nucleus pulposus (NP) lead to tissue dehydration and signal intensity loss on T2-weighted MR images. Pfirrmann grading is widely used for grading degeneration of intervertebral discs (IVDs). The criterion to differentiate IVDs of Pfirrmann Grade I from the other grades is NP homogeneity. Pfirrmann grading is qualitative and its assessment may be subjective. Therefore, assessment of quantitative objective measures correlating with early disc degeneration may complement the grading...
November 21, 2017: BMC Musculoskeletal Disorders
Lærke Priskorn, Jørgen H Petersen, Niels Jørgensen, Henriette B Kyhl, Marianne S Andersen, Katharina M Main, Anna-Maria Andersson, Niels E Skakkebaek, Tina K Jensen
BACKGROUND: Anogenital distance (AGD) has been suggested to represent a phenotypic signature reflecting in utero androgen action. However, it is not known whether an individual's AGD at birth correlates to AGD later in life. We investigate correlations of AGD between 3 and 18 months and asses reproducibility of measurements. METHODS: We measured AGD from anus to scrotum (AGDas) and penis (AGDap) in 407 boys, and to posterior fourchette (AGDaf) and clitoris (AGDac) in 282 girls...
November 20, 2017: Pediatric Research
Justyna Dunaj, Anna Moniuszko-Malinowska, Izabela Swiecicka, Martin Andersson, Piotr Czupryna, Krzysztof Rutkowski, Grzegorz Zambrowski, Joanna Zajkowska, Sambor Grygorczuk, Maciej Kondrusik, Renata Świerzbińska, Sławomir Pancewicz
AIM: The aim of the study was the evaluation of the frequency of infections and co-infections among patients hospitalized because of non-specific symptoms after a tick bite. MATERIALS AND METHODS: Whole blood, serum and cerebrospinal fluid samples from 118 patients hospitalised for non-specific symptoms up to 8 weeks after tick bite from 2010 to 2013 were examined for tick-borne infections. ELISA, Western blot and/or molecular biology (PCR; fla gene; 16S rRNA; sequencing) and thin blood smears (MDD) were used...
November 7, 2017: Advances in Medical Sciences
Joakim Bjerketorp, Jolanta J Levenfors, Christer Sahlberg, Christina L Nord, Pierre F Andersson, Bengt Guss, Bo Öberg, Anders Broberg
Bioassay-guided fractionation of culture extracts of Serratia plymuthica strain MF371-2 resulted in the isolation of two new antibacterial compounds with potent activity against Gram-positive bacteria, including Staphylococcus aureus LMG 15975 (MRSA). A spectroscopic investigation, in combination with synthesis, enabled the characterization of the compounds as 3-butyryl-4-hydroxy-6-heptyl-5,6-dihydro-2H-pyran-2-one (plymuthipyranone A, 1) and 3-butyryl-4-hydroxy-6-nonyl-5,6-dihydro-2H-pyran-2-one (plymuthipyranone B, 2)...
October 30, 2017: Journal of Natural Products
Emmanoel V Costa, Liviane N Soares, Maria L B Pinheiro, Beatriz H L N S Maia, Francisco A Marques, Andersson Barison, Jackson R G S Almeida, Iran L Sousa, Renan S Galaverna, Gabriel Heerdt, Nelson H Morgon, Leonard D R Acho, Emerson S Lima, Felipe M A da Silva, Hector H F Koolen
Three guaianolide sesquiterpenes, denoted guatterfriesols A-C, and four aporphine alkaloid derivatives were isolated from the stem bark of the Amazonian plant Guatteria friesiana. Thus far, sesquiterpene lactones have not been described in Annonaceae. Structures of the previously undescribed compounds were established by using 1D and 2D NMR spectroscopy in combination with MS. The absolute stereochemistry was assigned via NOE NMR experiments, ECD spectroscopy, and theoretical calculations using the TDDFT approach...
October 20, 2017: Phytochemistry
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