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Andersson B. S.

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https://www.readbyqxmd.com/read/29783114/geosphere-biosphere-circulation-of-chemical-elements-in-soil-and-plant-systems-from-a-100-km-transect-from-southern-central-norway
#1
Clemens Reimann, Karl Fabian, Belinda Flem, Malin Andersson, Peter Filzmoser, Peter Englmaier
Geochemical element separation is studied in 14 different sample media collected at 41 sites along an approximately 100-km long transect north of Oslo. At each site, soil C and O horizons and 12 plant materials (birch/spruce/cowberry/blueberry leaves/needles and twigs, horsetail, braken fern, pine bark and terrestrial moss) were sampled. The observed concentrations of 29 elements (K, Ca, P, Mg, Mn, S, Fe, Zn, Na, B, Cu, Mo, Co, Al, Ba, Rb, Sr, Ti, Ni, Pb, Cs, Cd, Ce, Sn, La, Tl, Y, Hg, Ag) were used to investigate soil-plant relations, and to evaluate the element differentiation between different plants, or between foliage and twigs of the same plant...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29755449/immunization-elicits-antigen-specific-antibody-sequestration-in-dorsal-root-ganglia-sensory-neurons
#2
Manojkumar Gunasekaran, Prodyot K Chatterjee, Andrew Shih, Gavin H Imperato, Meghan Addorisio, Gopal Kumar, Annette Lee, John F Graf, Dan Meyer, Michael Marino, Christopher Puleo, Jeffrey Ashe, Maureen A Cox, Tak W Mak, Chad Bouton, Barbara Sherry, Betty Diamond, Ulf Andersson, Thomas R Coleman, Christine N Metz, Kevin J Tracey, Sangeeta S Chavan
The immune and nervous systems are two major organ systems responsible for host defense and memory. Both systems achieve memory and learning that can be retained, retrieved, and utilized for decades. Here, we report the surprising discovery that peripheral sensory neurons of the dorsal root ganglia (DRGs) of immunized mice contain antigen-specific antibodies. Using a combination of rigorous molecular genetic analyses, transgenic mice, and adoptive transfer experiments, we demonstrate that DRGs do not synthesize these antigen-specific antibodies, but rather sequester primarily IgG1 subtype antibodies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29754777/international-validation-of-the-consensus-immunoscore-for-the-classification-of-colon-cancer-a-prognostic-and-accuracy-study
#3
Franck Pagès, Bernhard Mlecnik, Florence Marliot, Gabriela Bindea, Fang-Shu Ou, Carlo Bifulco, Alessandro Lugli, Inti Zlobec, Tilman T Rau, Martin D Berger, Iris D Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Y Wang, P Bavi, Michael H A Roehrl, Pamela S Ohashi, Linh T Nguyen, SeongJun Han, Heather L MacGregor, Sara Hafezi-Bakhtiari, Bradly G Wouters, Giuseppe V Masucci, Emilia K Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Bénédicte Buttard, Mihaela Angelova, Angela Vasaturo, Pauline Maby, Sarah E Church, Helen K Angell, Lucie Lafontaine, Daniela Bruni, Carine El Sissy, Nacilla Haicheur, Amos Kirilovsky, Anne Berger, Christine Lagorce, Jeffrey P Meyers, Christopher Paustian, Zipei Feng, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Kyogo Itoh, Prabhu S Patel, Hemangini H Vora, Birva Shah, Jayendrakumar B Patel, Kruti N Rajvik, Shashank J Pandya, Shilin N Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M Marincola, Paolo A Ascierto, Daniel J Sargent, Bernard A Fox, Jérôme Galon
BACKGROUND: The estimation of risk of recurrence for patients with colon carcinoma must be improved. A robust immune score quantification is needed to introduce immune parameters into cancer classification. The aim of the study was to assess the prognostic value of total tumour-infiltrating T-cell counts and cytotoxic tumour-infiltrating T-cells counts with the consensus Immunoscore assay in patients with stage I-III colon cancer. METHODS: An international consortium of 14 centres in 13 countries, led by the Society for Immunotherapy of Cancer, assessed the Immunoscore assay in patients with TNM stage I-III colon cancer...
May 10, 2018: Lancet
https://www.readbyqxmd.com/read/29743610/sex-specific-glioma-genome-wide-association-study-identifies-new-risk-locus-at-3p21-31-in-females-and-finds-sex-differences-in-risk-at-8q24-21
#4
Quinn T Ostrom, Ben Kinnersley, Margaret R Wrensch, Jeanette E Eckel-Passow, Georgina Armstrong, Terri Rice, Yanwen Chen, John K Wiencke, Lucie S McCoy, Helen M Hansen, Christopher I Amos, Jonine L Bernstein, Elizabeth B Claus, Dora Il'yasova, Christoffer Johansen, Daniel H Lachance, Rose K Lai, Ryan T Merrell, Sara H Olson, Siegal Sadetzki, Joellen M Schildkraut, Sanjay Shete, Joshua B Rubin, Justin D Lathia, Michael E Berens, Ulrika Andersson, Preetha Rajaraman, Stephen J Chanock, Martha S Linet, Zhaoming Wang, Meredith Yeager, Richard S Houlston, Robert B Jenkins, Beatrice Melin, Melissa L Bondy, Jill S Barnholtz-Sloan
Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29694170/precision-measurement-of-the-e-e-%C3%A2-%C3%AE-_-c-%C3%AE-over-%C3%A2-_-c-cross-section-near-threshold
#5
M Ablikim, M N Achasov, S Ahmed, M Albrecht, M Alekseev, A Amoroso, F F An, Q An, J Z Bai, Y Bai, O Bakina, R Baldini Ferroli, Y Ban, K Begzsuren, D W Bennett, J V Bennett, N Berger, M Bertani, D Bettoni, F Bianchi, E Boger, I Boyko, R A Briere, H Cai, X Cai, O Cakir, A Calcaterra, G F Cao, S A Cetin, J Chai, J F Chang, G Chelkov, G Chen, H S Chen, J C Chen, M L Chen, P L Chen, S J Chen, X R Chen, Y B Chen, X K Chu, G Cibinetto, F Cossio, H L Dai, J P Dai, A Dbeyssi, D Dedovich, Z Y Deng, A Denig, I Denysenko, M Destefanis, F De Mori, Y Ding, C Dong, J Dong, L Y Dong, M Y Dong, Z L Dou, S X Du, P F Duan, J Fang, S S Fang, Y Fang, R Farinelli, L Fava, S Fegan, F Feldbauer, G Felici, C Q Feng, E Fioravanti, M Fritsch, C D Fu, Q Gao, X L Gao, Y Gao, Y G Gao, Z Gao, B Garillon, I Garzia, A Gilman, K Goetzen, L Gong, W X Gong, W Gradl, M Greco, M H Gu, Y T Gu, A Q Guo, R P Guo, Y P Guo, A Guskov, Z Haddadi, S Han, X Q Hao, F A Harris, K L He, X Q He, F H Heinsius, T Held, Y K Heng, T Holtmann, Z L Hou, H M Hu, J F Hu, T Hu, Y Hu, G S Huang, J S Huang, X T Huang, X Z Huang, Z L Huang, T Hussain, W Ikegami Andersson, Q Ji, Q P Ji, X B Ji, X L Ji, X S Jiang, X Y Jiang, J B Jiao, Z Jiao, D P Jin, S Jin, Y Jin, T Johansson, A Julin, N Kalantar-Nayestanaki, X S Kang, M Kavatsyuk, B C Ke, T Khan, A Khoukaz, P Kiese, R Kliemt, L Koch, O B Kolcu, B Kopf, M Kornicer, M Kuemmel, M Kuhlmann, A Kupsc, W Kühn, J S Lange, M Lara, P Larin, L Lavezzi, H Leithoff, C Li, Cheng Li, D M Li, F Li, F Y Li, G Li, H B Li, H J Li, J C Li, J W Li, Jin Li, K J Li, Kang Li, Ke Li, Lei Li, P L Li, P R Li, Q Y Li, W D Li, W G Li, X L Li, X N Li, X Q Li, Z B Li, H Liang, Y F Liang, Y T Liang, G R Liao, J Libby, C X Lin, D X Lin, B Liu, B J Liu, C X Liu, D Liu, F H Liu, Fang Liu, Feng Liu, H B Liu, H L Liu, H M Liu, Huanhuan Liu, Huihui Liu, J B Liu, J Y Liu, K Liu, K Y Liu, Ke Liu, L D Liu, Q Liu, S B Liu, X Liu, Y B Liu, Z A Liu, Zhiqing Liu, Y F Long, X C Lou, H J Lu, J G Lu, Y Lu, Y P Lu, C L Luo, M X Luo, X L Luo, S Lusso, X R Lyu, F C Ma, H L Ma, L L Ma, M M Ma, Q M Ma, T Ma, X N Ma, X Y Ma, Y M Ma, F E Maas, M Maggiora, Q A Malik, Y J Mao, Z P Mao, S Marcello, Z X Meng, J G Messchendorp, G Mezzadri, J Min, R E Mitchell, X H Mo, Y J Mo, C Morales Morales, N Yu Muchnoi, H Muramatsu, A Mustafa, Y Nefedov, F Nerling, I B Nikolaev, Z Ning, S Nisar, S L Niu, X Y Niu, S L Olsen, Q Ouyang, S Pacetti, Y Pan, M Papenbrock, P Patteri, M Pelizaeus, J Pellegrino, H P Peng, Z Y Peng, K Peters, J Pettersson, J L Ping, R G Ping, A Pitka, R Poling, V Prasad, H R Qi, M Qi, T Y Qi, S Qian, C F Qiao, N Qin, X S Qin, Z H Qin, J F Qiu, K H Rashid, C F Redmer, M Richter, M Ripka, M Rolo, G Rong, Ch Rosner, A Sarantsev, M Savrié, C Schnier, K Schoenning, W Shan, X Y Shan, M Shao, C P Shen, P X Shen, X Y Shen, H Y Sheng, X Shi, J J Song, W M Song, X Y Song, S Sosio, C Sowa, S Spataro, G X Sun, J F Sun, L Sun, S S Sun, X H Sun, Y J Sun, Y K Sun, Y Z Sun, Z J Sun, Z T Sun, Y T Tan, C J Tang, G Y Tang, X Tang, I Tapan, M Tiemens, B Tsednee, I Uman, G S Varner, B Wang, B L Wang, D Wang, D Y Wang, Dan Wang, K Wang, L L Wang, L S Wang, M Wang, Meng Wang, P Wang, P L Wang, W P Wang, X F Wang, Y Wang, Y D Wang, Y F Wang, Y Q Wang, Z Wang, Z G Wang, Z Y Wang, Zongyuan Wang, T Weber, D H Wei, J H Wei, P Weidenkaff, S P Wen, U Wiedner, M Wolke, L H Wu, L J Wu, Z Wu, L Xia, Y Xia, D Xiao, Y J Xiao, Z J Xiao, Y G Xie, Y H Xie, X A Xiong, Q L Xiu, G F Xu, J J Xu, L Xu, Q J Xu, Q N Xu, X P Xu, F Yan, L Yan, W B Yan, W C Yan, Y H Yan, H J Yang, H X Yang, L Yang, Y H Yang, Y X Yang, Yifan Yang, M Ye, M H Ye, J H Yin, Z Y You, B X Yu, C X Yu, J S Yu, C Z Yuan, Y Yuan, A Yuncu, A A Zafar, Y Zeng, Z Zeng, B X Zhang, B Y Zhang, C C Zhang, D H Zhang, H H Zhang, H Y Zhang, J Zhang, J L Zhang, J Q Zhang, J W Zhang, J Y Zhang, J Z Zhang, K Zhang, L Zhang, S Q Zhang, X Y Zhang, Y Zhang, Y H Zhang, Y T Zhang, Yang Zhang, Yao Zhang, Yu Zhang, Z H Zhang, Z P Zhang, Z Y Zhang, G Zhao, J W Zhao, J Y Zhao, J Z Zhao, Lei Zhao, Ling Zhao, M G Zhao, Q Zhao, S J Zhao, T C Zhao, Y B Zhao, Z G Zhao, A Zhemchugov, B Zheng, J P Zheng, Y H Zheng, B Zhong, L Zhou, Q Zhou, X Zhou, X K Zhou, X R Zhou, X Y Zhou, A N Zhu, J Zhu, K Zhu, K J Zhu, S Zhu, S H Zhu, X L Zhu, Y C Zhu, Y S Zhu, Z A Zhu, J Zhuang, B S Zou, J H Zou
The cross section of the e^{+}e^{-}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} process is measured with unprecedented precision using data collected with the BESIII detector at sqrt[s]=4574.5, 4580.0, 4590.0 and 4599.5 MeV. The nonzero cross section near the Λ_{c}^{+}Λ[over ¯]_{c}^{-} production threshold is cleared. At center-of-mass energies sqrt[s]=4574.5 and 4599.5 MeV, the higher statistics data enable us to measure the Λ_{c} polar angle distributions. From these, the Λ_{c} electric over magnetic form-factor ratios (|G_{E}/G_{M}|) are measured for the first time...
March 30, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29659964/universal-salt-iodization-provides-sufficient-dietary-iodine-to-achieve-adequate-iodine-nutrition-during-the-first-1000-days-a-cross-sectional-multicenter-study
#6
Susanne Dold, Michael B Zimmermann, Tomislav Jukic, Zvonko Kusic, Qingzhen Jia, Zhongna Sang, Antonio Quirino, Teofilo O L San Luis, Ralph Fingerhut, Roland Kupka, Arnold Timmer, Greg S Garrett, Maria Andersson
Background: Dietary iodine requirements are high during pregnancy, lactation, and infancy, making women and infants vulnerable to iodine deficiency. Universal salt iodization (USI) has been remarkably successful for preventing iodine deficiency in the general population, but it is uncertain if USI provides adequate iodine intakes during the first 1000 d. Objective: We set out to assess if USI provides sufficient dietary iodine to meet the iodine requirements and achieve adequate iodine nutrition in all vulnerable population groups...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29596278/changes-in-lumbar-endplate-area-and-concavity-associated-with-disc-degeneration
#7
Philip K Louie, Alejandro A Espinoza Orías, Louis F Fogg, Mark LaBelle, Howard S An, Gunnar B J Andersson, Nozomu Inoue
STUDY DESIGN: Retrospective image-based analysis. OBJECTIVE: To measure endplate three-dimensional (3D) geometry, endplate changes in vivo and to investigate correlations between disc degeneration and endplate 3D geometry dependent on symptoms of low back pain (LBP). SUMMARY OF BACKGROUND DATA: It has been hypothesized that alteration of load transmission from the nucleus pulposus to the annulus fibrosus affects vertebral endplate geometry...
March 27, 2018: Spine
https://www.readbyqxmd.com/read/29589432/high-performance-organic-photodetectors-from-a-high-bandgap-indacenodithiophene-based-%C3%AF-conjugated-d-a-polymer
#8
Cindy Montenegro Benavides, Petri Murto, Christos Chochos, Vasilis Gregoriou, Apostolos Avgeropoulos, Xiaofeng Xu, Kim Bini, Anirudh Sharma, Mats Andersson, Oliver Schmidt, Christoph J Brabec, Ergang Wang, Sandro Francesco Tedde
A conjugated donor-acceptor (D-A) polymer, poly[4,4,9,9-tetrakis(4-hexylphenyl)-4,9-dihydro-s-indaceno[1,2-b:5,6-b']dithiophene-2,7-diyl-alt-5-(2-ethylhexyl)-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione-1,3-diyl] (PIDT-TPD), is blended with the fullerene derivative [6,6]phenyl-C61-butyric acid methyl ester (PC61 BM) for the fabrication of thin and solution-processed organic photodetectors (OPDs). Systematic screening of the concentration ratio of the blend and the molecular weight of the polymer is performed in order to optimize the active layer morphology and the OPDs performance...
March 28, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29571068/robust-high-yield-1-tbq-production-of-cyclotron-based-sodium-99m-tc-pertechnetate
#9
J D Andersson, B Thomas, S V Selivanova, E Berthelette, J S Wilson, A J B McEwan, K Gagnon
This paper presents the irradiation and processing of high-current100 Mo targets at the University of Alberta (UofA) in a GMP compliant setting. For purpose of comparison with a second production facility, additional studies at Centre Hospitalier Universitaire de Sherbrooke (CHUS) are also described. INTRODUCTION: More than 70% of today's diagnostic radiopharmaceuticals are based on99m Tc, however the conventional supply chain for obtaining99m Tc is fragile. The aim of this work was to demonstrate reliable high yield production and processing of99m Tc with medium-energy, high-current, cyclotrons...
March 2, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29547834/a-randomised-study-of-tailored-toxicity-based-dosage-of-fluorouracil-epirubicin-cyclophosphamide-chemotherapy-for-early-breast-cancer-sbg-2000-1
#10
H Lindman, M Andersson, J Ahlgren, E Balslev, A Sverrisdottir, S B Holmberg, N O Bengtsson, E H Jacobsen, A B Jensen, J Hansen, M K Tuxen, L Malmberg, K Villman, H Anderson, B Ejlertsen, J Bergh, C Blomqvist
STUDY AIM: Retrospective studies have demonstrated a worse outcome in breast cancer patients not developing leukopenia during adjuvant chemotherapy. The SBG 2000-1 is the first randomised trial designed to compare individually dosed chemotherapy without G-CSF support based on grade of toxicity to standard-dosed chemotherapy based on body surface area (BSA). METHODS: Patients with early breast cancer were included and received the first cycle of standard FEC (fluorouracil 600 mg/m2 , epirubicin 60 mg/m2 , cyclophosphamide 600 mg/m2 )...
May 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29544534/efficacy-and-safety-of-secukinumab-administration-by-autoinjector-in-patients-with-psoriatic-arthritis-results-from-a-randomized-placebo-controlled-trial-future-3
#11
Peter Nash, Philip J Mease, Iain B McInnes, Proton Rahman, Christopher T Ritchlin, Ricardo Blanco, Eva Dokoupilova, Mats Andersson, Radhika Kajekar, Shephard Mpofu, Luminita Pricop
BACKGROUND: The study aimed to assess 52-week efficacy and safety of secukinumab self-administration by autoinjector in patients with active psoriatic arthritis (PsA) in the FUTURE 3 study ( ClinicalTrials.gov NCT01989468). METHODS: Patients (≥ 18 years of age; N = 414) with active PsA were randomized 1:1:1 to subcutaneous (s.c.) secukinumab 300 mg, 150 mg, or placebo at baseline, weeks 1, 2, 3, and 4, and every 4 weeks thereafter. Per clinical response, placebo-treated patients were re-randomized to s...
March 15, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29516218/neural-crest-stem-cells-protect-spinal-cord-neurons-from-excitotoxic-damage-and-inhibit-glial-activation-by-secretion-of-brain-derived-neurotrophic-factor
#12
Nikos Schizas, N König, B Andersson, S Vasylovska, J Hoeber, E N Kozlova, N P Hailer
The acute phase of spinal cord injury is characterized by excitotoxic and inflammatory events that mediate extensive neuronal loss in the gray matter. Neural crest stem cells (NCSCs) can exert neuroprotective and anti-inflammatory effects that may be mediated by soluble factors. We therefore hypothesize that transplantation of NCSCs to acutely injured spinal cord slice cultures (SCSCs) can prevent neuronal loss after excitotoxic injury. NCSCs were applied onto SCSCs previously subjected to N-methyl-D-aspartate (NMDA)-induced injury...
June 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29512054/peripartum-care-for-mothers-diagnosed-with-hepatitis-b-during-pregnancy-a-survey-of-provider-practices
#13
Allison J Kwong, Matthew S Chang, Ruth E Tuomala, Laura E Riley, Julian N Robinson, Muthoka L Mutinga, Karin L Andersson, Robert S Brown, Emily Oken, Chinweike Ukomadu, Anna E Rutherford
Objectives Hepatitis B (HBV) remains a significant public health burden, despite effective therapy. Routine HBV screening is recommended during pregnancy to reduce the risk of vertical transmission, but the rates of follow-up care peri-partum are low. The aim of this study was to evaluate physician practices and knowledge regarding HBV in women diagnosed perinatally. Methods A survey was distributed to obstetricians and midwives within the Partners HealthCare system at Brigham and Women's Hospital and Massachusetts General Hospital...
March 6, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29501779/phase-ii-trial-of-high-dose-gemcitabine-busulfan-melphalan-with-autologous-stem-cell-transplantation-for-primary-refractory-or-poor-risk-relapsed-hodgkin-lymphoma
#14
Yago Nieto, Peter F Thall, Junsheng Ma, Benigno C Valdez, Sairah Ahmed, Paolo Anderlini, Uday Popat, Roy B Jones, Elizabeth J Shpall, Chitra Hosing, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Melissa Timmons, Alison Gulbis, Alan Myers, Yasuhiro Oki, Michelle Fanale, Bouthaina Dabaja, Chelsea Pinnix, Sarah Milgrom, Richard Champlin, Borje S Andersson
We conducted a prospective phase 2 trial of gemcitabine, busulfan and melphalan (Gem/Bu/Mel) with autologous stem cell transplantation (ASCT) in patients with primary refractory or poor-risk relapsed Hodgkin lymphoma (HL) (ie, extranodal relapse or within 1 year of frontline therapy). The trial was powered to detect an improvement in 2-year progression-free survival (PFS) from a historical 50% using a BEAM regimen (carmustine/etoposide/cytarabine/melphalan) to 65%. We compared the study population with all other concurrent patients who were eligible for the trial but instead received the BEAM regimen at our center...
March 2, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29494619/shared-activity-patterns-arising-at-genetic-susceptibility-loci-reveal-underlying-genomic-and-cellular-architecture-of-human-disease
#15
J Kenneth Baillie, Andrew Bretherick, Christopher S Haley, Sara Clohisey, Alan Gray, Lucile P A Neyton, Jeffrey Barrett, Eli A Stahl, Albert Tenesa, Robin Andersson, J Ben Brown, Geoffrey J Faulkner, Marina Lizio, Ulf Schaefer, Carsten Daub, Masayoshi Itoh, Naoto Kondo, Timo Lassmann, Jun Kawai, Damian Mole, Vladimir B Bajic, Peter Heutink, Michael Rehli, Hideya Kawaji, Albin Sandelin, Harukazu Suzuki, Jack Satsangi, Christine A Wells, Nir Hacohen, Thomas C Freeman, Yoshihide Hayashizaki, Piero Carninci, Alistair R R Forrest, David A Hume
Genetic variants underlying complex traits, including disease susceptibility, are enriched within the transcriptional regulatory elements, promoters and enhancers. There is emerging evidence that regulatory elements associated with particular traits or diseases share similar patterns of transcriptional activity. Accordingly, shared transcriptional activity (coexpression) may help prioritise loci associated with a given trait, and help to identify underlying biological processes. Using cap analysis of gene expression (CAGE) profiles of promoter- and enhancer-derived RNAs across 1824 human samples, we have analysed coexpression of RNAs originating from trait-associated regulatory regions using a novel quantitative method (network density analysis; NDA)...
March 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29449575/actionable-perturbations-of-damage-responses-by-tcl1-atm-and-epigenetic-lesions-form-the-basis-of-t-pll
#16
A Schrader, G Crispatzu, S Oberbeck, P Mayer, S Pützer, J von Jan, E Vasyutina, K Warner, N Weit, N Pflug, T Braun, E I Andersson, B Yadav, A Riabinska, B Maurer, M S Ventura Ferreira, F Beier, J Altmüller, M Lanasa, C D Herling, T Haferlach, S Stilgenbauer, G Hopfinger, M Peifer, T H Brümmendorf, P Nürnberg, K S J Elenitoba-Johnson, S Zha, M Hallek, R Moriggl, H C Reinhardt, M-H Stern, S Mustjoki, S Newrzela, P Frommolt, M Herling
T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nucleotide sequences in 111 well-characterized patients. Besides prominent signatures of T-cell activation and prevalent clonal variants, we also identify novel hot-spots for CN variability, fusion molecules, alternative transcripts, and progression-associated dynamics. The overall lesional spectrum of T-PLL is mainly annotated to axes of DNA damage responses, T-cell receptor/cytokine signaling, and histone modulation...
February 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29404892/cerebral-oximetry-during-preoperative-resuscitation-in-elderly-patients-with-hip-fracture-a-prospective-observational-study
#17
C G Clemmesen, L M Pedersen, S Hougaard, M L Andersson, V Rosenkvist, H B Nielsen, H Palm, N B Foss
This study explores the association between postadmission and intraoperative cerebral oxygenation (ScO2 ), reflecting systemic perfusion, and postoperative mortality and delirium. Forty elderly (age > 65 years) patients with hip fractures were included in this prospective observational study. The ScO2 was determined using near-infrared spectroscopy at initial resuscitation after patients were admitted to the hospital and during surgery. Postoperative delirium was assessed up to seven days after surgery using the memorial delirium assessment scale and the confusion assessment method...
February 5, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29388792/transcription-factor-gata6-a-novel-marker-and-putative-inducer-of-ductal-metaplasia-in-biliary-atresia
#18
Tea Soini, Marjut Pihlajoki, Noora Andersson, Jouko Lohi, Kari A Huppert, David A Rudnick, Stacey S Huppert, David B Wilson, Mikko P Pakarinen, Markku Heikinheimo
Biliary atresia (BA), a neonatal liver disease, is characterized by obstruction of extrahepatic bile ducts with subsequent cholestasis, inflammation, and progressive liver fibrosis. To gain insights into the pathophysiology of BA, we focused attention on GATA6, a transcription factor implicated in biliary development. Early in fetal development GATA6 expression is evident in cholangiocytes and hepatocytes, but by late gestation it is extinguished in hepatocytes. Utilizing a unique set of BA liver samples collected before and after successful portoenterostomy (PE), we found that GATA6 expression is markedly upregulated in hepatocytes of patients with BA compared to healthy and cholestatic disease controls...
February 1, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29386578/a-model-species-for-agricultural-pest-genomics-the-genome-of-the-colorado-potato-beetle-leptinotarsa-decemlineata-coleoptera-chrysomelidae
#19
Sean D Schoville, Yolanda H Chen, Martin N Andersson, Joshua B Benoit, Anita Bhandari, Julia H Bowsher, Kristian Brevik, Kaat Cappelle, Mei-Ju M Chen, Anna K Childers, Christopher Childers, Olivier Christiaens, Justin Clements, Elise M Didion, Elena N Elpidina, Patamarerk Engsontia, Markus Friedrich, Inmaculada García-Robles, Richard A Gibbs, Chandan Goswami, Alessandro Grapputo, Kristina Gruden, Marcin Grynberg, Bernard Henrissat, Emily C Jennings, Jeffery W Jones, Megha Kalsi, Sher A Khan, Abhishek Kumar, Fei Li, Vincent Lombard, Xingzhou Ma, Alexander Martynov, Nicholas J Miller, Robert F Mitchell, Monica Munoz-Torres, Anna Muszewska, Brenda Oppert, Subba Reddy Palli, Kristen A Panfilio, Yannick Pauchet, Lindsey C Perkin, Marko Petek, Monica F Poelchau, Éric Record, Joseph P Rinehart, Hugh M Robertson, Andrew J Rosendale, Victor M Ruiz-Arroyo, Guy Smagghe, Zsofia Szendrei, Gregg W C Thomas, Alex S Torson, Iris M Vargas Jentzsch, Matthew T Weirauch, Ashley D Yates, George D Yocum, June-Sun Yoon, Stephen Richards
The Colorado potato beetle is one of the most challenging agricultural pests to manage. It has shown a spectacular ability to adapt to a variety of solanaceaeous plants and variable climates during its global invasion, and, notably, to rapidly evolve insecticide resistance. To examine evidence of rapid evolutionary change, and to understand the genetic basis of herbivory and insecticide resistance, we tested for structural and functional genomic changes relative to other arthropod species using genome sequencing, transcriptomics, and community annotation...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29386198/effect-of-nonpermissive-hla-dpb1-mismatches-after-unrelated-allogeneic-transplantation-with-in-vivo-t-cell-depletion
#20
Betül Oran, Rima M Saliba, Yudith Carmazzi, Marcos de Lima, Gabriela Rondon, Sairah Ahmed, Amin Alousi, Borje S Andersson, Paolo Anderlini, Michelle Alvarez, Qasier Bashir, Stefan Ciurea, Marcelo Fernandez-Vina, Chitra Hosing, Partow Kebriaei, Martin Korbling, Pedro Cano, Issa Khouri, David Marin, Yago Nieto, Amanda Olson, Uday Popat, Katy Rezvani, Muzaffar Qazilbash, Elizabeth J Shpall, Richard E Champlin, Kai Cao
We investigated the impact of donor-recipient HLA-DPB1 matching on outcomes of allogeneic hematopoietic stem cell transplantation with in vivo T-cell depletion using antithymocyte globulin (ATG) for patients with hematological malignancies. All donor-recipient pairs had high-resolution typing for HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1, HLA-DPB1, and HLA-DRB3/4/5 and were matched at HLA-A, HLA-B, HLA-C, and HLA-DRB1. HLA-DPB1 mismatches were categorized by immunogenicity of the DPB1 matching using the DPB T-cell epitope tool...
March 15, 2018: Blood
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