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https://www.readbyqxmd.com/read/28641383/neuroprotection-in-stroke-the-importance-of-collaboration-and-reproducibility
#1
Ain A Neuhaus, Yvonne Couch, Gina Hadley, Alastair M Buchan
Acute ischaemic stroke accounts for 6.5 million deaths per year, and by 2030 will result in the annual loss of over 200 million disability-adjusted life years globally. There have been considerable recent advances in the gold standard of acute ischaemic stroke treatment, some aspects of which-aspirin to prevent recurrence, and treating patients in specialized stroke wards-are widely applicable. Recanalization of the occluded artery through thrombolysis and/or endovascular thrombectomy is restricted to only a small proportion of patients, due to contra-indications and the costs associated with establishing the infrastructure to deliver these treatments...
June 20, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28641266/an-approach-to-identifying-phenomena-accompanying-micro-and-nanoparticles-in-contact-with-irregular-vessel-walls
#2
K Talaska, A Ferreira
OBJECTIVE: The objective of this manuscript is to present the method for determining the nature and values of the forces needed to set micro and nanoparticles sitting immobile at the blood vessel wall in motion. METHODS: The problem was tackled in two ways. Microparticles were examined as objects coming into contact with the wall with the actual large arteriole-type vessel structure. The forces acting on microparticles 10 μm, 30 μm and 50 μm in diameter were determined: drag force FD, lift force FL, electrostatic force FE and gravity force FG...
June 19, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28637235/monotherapy-with-either-dolutegravir-or-raltegravir-fails-to-durably-suppress-hiv-viraemia-in-humanized-mice
#3
Alonso Heredia, Said Hassounah, Sandra Medina-Moreno, Juan C Zapata, Nhut M Le, Yingshan Han, James S Foulke, Charles Davis, Joseph Bryant, Robert R Redfield, Mark A Wainberg
Objectives: To compare the effectiveness of HIV integrase inhibitor monotherapy between raltegravir and dolutegravir as an approach to simplify therapy. Methods: We evaluated and compared the efficacy of 20 week monotherapy with dolutegravir or raltegravir in humanized mice (HSC-NSG) infected with HIV BaL . Plasma HIV RNA was measured by quantitative RT-PCR (limit of detection of 150 copies/45 μL of plasma) and drug levels by LC-MS/MS. Escape viruses were genotyped and analysed for replication capacity and drug susceptibility in tissue culture...
June 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28633544/medical-versus-surgical-management-of-penetrating-crohn-s-disease-the-current-situation-and-future-perspectives
#4
Seema A Patil, Raymond K Cross
The development of penetrating Crohn's disease (CD) occurs in up to 50% of patients over the course of their lifetime. While the presentation of these complications, including free perforation, intra-abdominal abscess, and enteric fistula, are usually obvious, the management can require a nuanced approach, with distinct short and long-term approaches. Areas covered: This review discusses medical and surgical methods of treating these complications, including the role of percutaneous drainage of abscesses, the implications of a stricture associated with a fistula, and the efficacy of postoperative anti-TNF therapy in preventing recurrence after surgical treatment...
June 21, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28631376/scale-of-human-mobility-in-the-southern-andes-argentina-and-chile-a-new-framework-based-on-strontium-isotopes
#5
Ramiro Barberena, Víctor A Durán, Paula Novellino, Diego Winocur, Anahí Benítez, Augusto Tessone, María N Quiroga, Erik J Marsh, Alejandra Gasco, Valeria Cortegoso, Gustavo Lucero, Carina Llano, Kelly J Knudson
OBJECTIVES: The goal of this article is to assess the scale of human paleomobility and ecological complementarity between the lowlands and highlands in the southern Andes during the last 2,300 years. By providing isotope results for human bone and teeth samples, we assess a hypothesis of "high residential mobility" suggested on the basis of oxygen isotopes from human remains. METHODS: We develop an isotopic assessment of human mobility in a mountain landscape combining strontium and oxygen isotopes...
June 20, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28630518/a-call-for-an-integrated-program-of-assessment
#6
REVIEW
David W Fielding, Glenn Regehr
An integrated curriculum that does not incorporate equally integrated assessment strategies is likely to prove ineffective in achieving the desired educational outcomes. We suggest it is time for colleges and schools of pharmacy to re-engineer their approach to assessment. To build the case, we first discuss the challenges leading to the need for curricular developments in pharmacy education. We then turn to the literature that informs how assessment can influence learning, introduce an approach to learning assessment that is being used by several medical education programs, and provide some examples of this approach in operation...
May 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28630432/down-regulation-of-kca2-3-channels-causes-erectile-dysfunction-in-mice
#7
Simon Comerma-Steffensen, Attila Kun, Elise R Hedegaard, Susie Mogensen, Christian Aalkjaer, Ralf Köhler, Birgitte Mønster Christensen, Ulf Simonsen
Modulation of endothelial calcium-activated K(+) channels has been proposed as an approach to restore arterial endothelial cell function in disease. We hypothesized that small-conductance calcium-activated K(+) channels (KCa2.3 or SK3) contributes to erectile function. The research was performed in transgenic mice with overexpression (KCa2.3 (T/T(-Dox))) or down-regulation (KCa2.3 (T/T(+Dox))) of the KCa2.3 channels and wild-type C57BL/6-mice (WT). QPCR revealed that KCa2.3 and KCa1.1 channels were the most abundant in mouse corpus cavernosum...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630284/differential-interaction-of-dantrolene-glafenine-nalidixic-acid-and-prazosin-with-human-organic-anion-transporters-1-and-3-oat1-oat3
#8
Birgitta C Burckhardt, Maja Henjakovic, Yohannes Hagos, Gerhard Burckhardt
In renal proximal tubule cells, the organic anion transporters 1 and 3 (OAT1 and OAT3) in the basolateral membrane and the multi drug resistance-associated protein 4 (MRP4) in the apical membrane share substrates and co-operate in renal drug secretion. We hypothetized that recently identified MRP4 inhibitors, dantrolene, glafenine, nalidixic acid, and prazosin, also interact with human OAT1 and/or OAT3 stably transfected in HEK293 cells. These four drugs were tested as possible inhibitors of p-[3H]aminohippurate (PAH) and [14C]glutarate uptake by OAT1, and of [3H]estrone-3-sulfate (ES) uptake by OAT3...
June 19, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28629976/mapbot-meta-analytic-parcellation-based-on-text-and-its-application-to-the-human-thalamus
#9
Rui Yuan, Paul A Taylor, Tara L Alvarez, Durga Mishra, Bharat B Biswal
Meta-analysis of neuroimaging results has proven to be a popular and valuable method to study human brain functions. A number of studies have used meta-analysis to parcellate distinct brain regions. A popular way to perform meta-analysis is typically based on the reported activation coordinates from a number of published papers. However, in addition to the coordinates associated with the different brain regions, the text itself contains considerably amount of additional information. This textual information has been largely ignored in meta-analyses where it may be useful for simultaneously parcellating brain regions and studying their characteristics...
June 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28629810/spindle-cell-lesions-of-the-breast-an-approach-to-diagnosis
#10
REVIEW
Timothy Kwang Yong Tay, Puay Hoon Tan
Spindle cell lesions of the breast are among the less common entities encountered in breast pathology. They encompass a whole spectrum of benign reactive lesions to high grade malignant neoplasms. An accurate diagnosis is important to ensure that the patient receives the appropriate management. While this group of conditions broadly share the same basic morphology of a lesion composed of spindle cells, there are often recognizable differences on histology, which coupled with ancillary studies and correlation with the clinical and imaging findings, can help one to arrive at a specific diagnosis...
May 27, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28629657/single-unit-implant-supported-restoration-adjacent-to-multiple-lithium-disilicate-restorations-an-approach-to-an-esthetic-challenge-a-clinical-report
#11
Gelareh Ronaghi, Winston Chee, Stephanie Yeung
This clinical report describes a method for predictably shade matching a highly opaque yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) implant restoration adjacent to relatively translucent lithium disilicate veneers in the maxillary anterior region. To achieve a satisfactory outcome, the milled Y-TZP abutment was layered with low-fusing feldspathic porcelain to match the stump shade of the adjacent prepared teeth; this layer subsequently facilitated adhesive bonding of a veneer to the abutment before insertion...
June 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28627892/an-approach-to-fabricate-compact-gold-nanoparticles-film-with-the-assistance-of-a-surfactant
#12
Huan Min, Jun Zhou, Xiaojue Bai, Linlin Li, Kai Zhang, Tieqiang Wang, Xuemin Zhang, Yunong Li, Yonghua Jiao, Xuan Qi, Yu Fu
We report a facile method to fabricate a compact Au nanoparticles film with the assistance of surfactants. First, the dodecanethiol-coated Au nanoparticles were floated on the surface of the toluene/acetonitrile mixture solvent and adjusted to an expanded dispersion by changing the mixture ratio. The silicone oil was then added as a surfactant to compress the floating nanoparticles from the original loose status to a closely-packed arrangement which produced a compact nanoparticle film. The relationship of the compressed film area with the silicone oil concentration was plotted and compared with the surface tension curve of silicone oil...
June 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28627508/corrigendum-an-approach-to-and-web-based-tool-for-infectious-disease-outbreak-intervention-analysis
#13
Ashlynn R Daughton, Nicholas Generous, Reid Priedhorsky, Alina Deshpande
This corrects the article DOI: 10.1038/srep46076.
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28626832/fragment-binding-to-%C3%AE-secretase-1-without-catalytic-aspartate-interactions-identified-via-orthogonal-screening-approaches
#14
Frederik J R Rombouts, Richard Alexander, Erna Cleiren, Alex De Groot, Michel Carpentier, Joyce Dijkmans, Katleen Fierens, Stefan Masure, Diederik Moechars, Martina Palomino-Schätzlein, Antonio Pineda-Lucena, Andrés A Trabanco, Daan Van Glabbeek, Ann Vos, Gary Tresadern
An approach to identify β-secretase 1 (BACE1) fragment binders that do not interact with the catalytic aspartate dyad is presented. A ThermoFluor (thermal shift) and a fluorescence resonance energy transfer enzymatic screen on the soluble domain of BACE1, together with a surface plasmon resonance (SPR) screen on the soluble domain of BACE1 and a mutant of one catalytic Asp (D32N), were run in parallel. Fragments that were active in at least two of these assays were further confirmed using one-dimensional NMR (WaterLOGSY) and SPR binding competition studies with peptidic inhibitor OM99-2...
February 28, 2017: ACS Omega
https://www.readbyqxmd.com/read/28625873/an-approach-to-the-study-of-the-immunity-functions-of-bivalve-haemocytes-physiology-and-molecular-aspects
#15
REVIEW
Mario Alberto Burgos-Aceves, Caterina Faggio
The Mediterranean mussel Mytilus galloprovincialis is an ecologically and economically important species. It has been used in programs of monitoring of pollutions, since it is sessile organism that is capable of accumulating pollutants in tissues through filter feeding. Due to an increase of pollutants in the environment, marine mussels present physiological alterations that compromise their innate immune system, which can latter lead to opportunistic diseases. The haemocytes are the cells in charge of the immune response in the Mediterranean mussel and in other mollusks...
June 15, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28625853/photoelicitation-a-useful-tool-to-investigate-management-of-the-vulnerability-of-homeless-women
#16
Cristina Oter-Quintana, Teresa González-Gil, Ángel Martín-García, María Teresa Alcolea-Cosín
AIMS: The proposal of the manuscript is to provide a methodological reflection on the use of photo-elicitation as a data gathering strategy to explore vulnerability management among homeless women. METHODS: A grounded theory study was carried out. Photo elicitation was one of the data gathering techniques used between February 2015 and February 2017. Five women were selected through intentional sampling. All of them were over 18 years old and residents in 4 shelters within the Madrid Care for the Homeless network...
June 15, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28624754/automatic-segmentation-of-the-lumen-region-in-intravascular-images-of-the-coronary-artery
#17
Danilo Samuel Jodas, Aledir Silveira Pereira, João Manuel R S Tavares
Image assessment of the arterial system plays an important role in the diagnosis of cardiovascular diseases. The segmentation of the lumen and media-adventitia in intravascular (IVUS) images of the coronary artery is the first step towards the evaluation of the morphology of the vessel under analysis and the identification of possible atherosclerotic lesions. In this study, a fully automatic method for the segmentation of the lumen in IVUS images of the coronary artery is presented. The proposed method relies on the K-means algorithm and the mean roundness to identify the region corresponding to the potential lumen...
June 10, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28623628/does-patient-preference-measurement-in-decision-aids-improve-decisional-conflict-a-randomized-trial-in-men-with-prostate-cancer
#18
Joseph D Shirk, Catherine M Crespi, Josemanuel D Saucedo, Sylvia Lambrechts, Ely Dahan, Robert Kaplan, Christopher Saigal
BACKGROUND: Shared decision making (SDM) has been advocated as an approach to medical decision making that can improve decisional quality. Decision aids are tools that facilitate SDM in the context of limited physician time; however, many decision aids do not incorporate preference measurement. OBJECTIVES: We aim to understand whether adding preference measurement to a standard patient educational intervention improves decisional quality and is feasible in a busy clinical setting...
June 16, 2017: Patient
https://www.readbyqxmd.com/read/28622821/the-therapeutic-discharge-an-approach-to-dealing-with-deceptive-patients
#19
John B Taylor, Scott R Beach, Nicholas Kontos
OBJECTIVE: Patients with factitious disorder or malingering behaviors pose particular problems in acute care settings. We sought to describe a manner to effectively discharge these patients and keep further harm, iatrogenic or otherwise, from being inflicted. METHOD: Once an indication has been identified, the therapeutic discharge can be carried out in a stepwise fashion, resulting in a safe discharge. We outlined how to prepare for, and execute, the therapeutic discharge, along with preemptive consideration of complications that may arise...
May 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28621950/direct-observation-of-the-symmetrical-and-asymmetrical-protonation-states-in-molecular-crystals
#20
Suqian Ma, Jibo Zhang, Yingjie Liu, Jingyu Qian, Bin Xu, Wenjing Tian
The symmetrical and asymmetrical protonation states are realized via the formation of intermolecular hydrogen bonds inside 9,10-bis((E)-2-(pyridin-4-yl)vinyl)anthracene (BP4VA) molecular crystals. With the protonation of H2SO4, BP4VA molecules are protonated symmetrically, while the molecules are asymmetrically protonated by introducing HCl. The different protonation states of BP4VA crystals result in various supramolecular interactions, aggregation states, and even tunable optical properties. It provides a fundamental principle to understand the effect of protonation in organic conjugated molecules and an approach to expanding the scope of organic functional materials...
June 21, 2017: Journal of Physical Chemistry Letters
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