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https://www.readbyqxmd.com/read/28805378/in-vitro-modulation-of-renin-angiotensin-system-enzymes-by-amaranth-amaranthus-hypochondriacus-protein-derived-peptides-alternative-mechanisms-different-from-ace-inhibition
#1
Alejandra V Quiroga, Paula Aphalo, Agustina Estefanía Nardo, María Cristina Añón
Among the factors affecting the development of cardiovascular diseases, hypertension is one of the most important. Research done on amaranth proteins has demonstrated their hypotensive capacity in vivo and in vitro; nevertheless the mechanism underlying this effect remains unclear. The aim of this study was to analyze in vitro the inhibition of peptides derived from an amaranth hydrolysate (AHH) on other RAS enzymes other than ACE. The chymase and renin activities were studied. AHH was not able to inhibit chymase activity although a dose-response effect was found on renin activity (IC50 0...
August 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28803650/lipid-determination-in-bone-marrow-and-mineralized-bone-tissue-from-sample-preparation-to-improved-high-performance-thin-layer-and-liquid-chromatographic-approaches
#2
Alexandrine During
In view of their key roles in the bone physiology (e.g., in the biomineralization process) and their potential implication in bone pathologies, an approach to study lipids in situ is needed. The aim of the present paper is to propose an original procedure to characterize lipids in both bone marrow (BM) and mineralized tissue (MT) compartments, taking into consideration sample preparation, lipid extraction and analytical issues, when using small sample size (≤ 0.5g of rat femurs). The potential contamination of the MT by marrow lipids and the poor accessibility of certain lipids from the MT - two major issues in bone handling - were taking care, respectively by performing two cleaning steps after BM removal and by adding a demineralization step to the overall lipid extraction protocol...
August 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28802940/fatigue-in-parkinson-s-disease
#3
Benzi M Kluger
Fatigue is a common symptom in Parkinson's disease (PD), affecting approximately half of all patients. Fatigue is a significant contributor to reduction in quality of life and is a leading cause of disability. Despite the clear impact of fatigue on persons living with PD, research progress has been slow in this area in terms of uncovering the mechanisms of fatigue and there are currently no evidence-based treatments. Although fatigue is often viewed as a subjective and nonspecific symptom which cannot be studied rigorously, there is an emerging science of fatigue which is based on a careful and precise taxonomy of the construct of fatigue...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28802444/identifying-the-critical-physical-demanding-tasks-of-paramedic-work-towards-the-development-of-a-physical-employment-standard
#4
Steven L Fischer, Kathryn E Sinden, Renee S MacPhee
Public safety related occupations including police, fire and military commonly apply physical employment standard (PES) to facilitate job matching, an approach to evaluate if candidates demonstrate acceptable physical capabilities as required to perform the job safely and effectively. In Canada, paramedics remain as one of the few public safety occupations without an evidence-based, validated PES. The purpose of this study was to document and describe the physical demands of paramedic work and to identify the most physically demanding tasks...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28802090/assessment-of-the-dynamics-of-human-glymphatic-system-by-near-infrared-spectroscopy-nirs
#5
Teemu Myllylä, Markus Harju, Vesa Korhonen, Alexander Bykov, Vesa Kiviniemi, Igor Meglinski
Fluctuations in brain water content has attracted increasing interest, particularly as regards studies of the glymphatic system, which is connected with the complex organisation of dural lymphatic vessels, responsible for cleaning tissue. Disturbances of glymphatic circulation are associated with several brain disorders, including dementia. This paper introduces an approach to non-invasive measurement of water dynamics in the human brain utilizing near-infrared spectroscopy (NIRS). We demonstrate the possibility to sense dynamic variations of water content between the skull and grey matter, for instance, in the subarachnoid space...
August 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28801910/application-of-synthetic-tumor-specific-promoters-responsive-to-the-tumor-microenvironment
#6
Eduardo G Cafferata, Maria Veronica Lopez, Felipe J Nuñez, Maria A R Maenza, Osvaldo L Podhajcer
Activity of endogenous promoters can be altered by including additional responsive elements (REs). These elements can be responsive to features of the tumor environment or alternatively to signaling pathways specifically activated in cancer cells. These REs incorporated into tumor-specific promoters can improve cancer targeting, the replicative capacity, and lytic activity of conditionally replicative adenovirus. Here we outline an approach to incorporate hypoxia and inflammation REs into a specific fragment of the SPARC promoter and the steps to clone a nucleosome positioning sequence (NPS ) identified in the osteocalcin promoter that contains a Wnt RE upstream of a heterologous synthetic promoter...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28800869/the-role-of-ca3-gabab-receptors-on-anxiolytic-like-behaviors-and-avoidance-memory-deficit-induced-by-d-ap5-with-respect-to-ca-2-ions
#7
Shahram Zarrabian, Mohammad Nasehi, Maryam Farrahizadeh, Mohammad-Reza Zarrindast
Glutamatergic and GABAergic systems play key roles in the hippocampus and affect the pathogenesis of anxiety- and memory-related processes. Some investigations have assessed the role of balancing the function of these two systems in different areas of the central nervous system (CNS) as an approach to manage the related disorders. We investigated the anxiety and avoidance memory states using the test-retest protocol in the elevated plus maze to understand the role of GABAB receptors (GABABRs) in relation to the NMDA receptor blockade by D-AP5 (an NMDA receptor antagonist)...
August 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28800626/targeting-lysyl-oxidase-reduces-peritoneal-fibrosis
#8
Christopher R Harlow, Xuan Wu, Marielle van Deemter, Fiona Gardiner, Craig Poland, Rebecca Green, Sana Sarvi, Pamela Brown, Karl E Kadler, Yinhui Lu, J Ian Mason, Hilary O D Critchley, Stephen G Hillier
BACKGROUND: Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent feature. Lysyl oxidase (Lox) is a key enzyme required for crosslinking and deposition of insoluble collagen, so we investigated whether targeting Lox might be an approach to reduce abdominal adhesions. METHODS: Female C57Bl/6 mice were treated intraperitoneally with multiwalled carbon nanotubes (NT) to induce fibrosis, together with chemical (ß-aminoproprionitrile-BAPN) or miRNA Lox inhibitors, progesterone or dexamethasone...
2017: PloS One
https://www.readbyqxmd.com/read/28800493/efficient-simulation-of-elastic-guided-waves-interacting-with-notches-adhesive-joints-delaminations-and-inclined-edges-in-plate-structures
#9
Hauke Gravenkamp
This paper presents an approach to model transmission and reflection phenomena of elastic guided waves in plates. The formulation is applied to plate structures containing notches, inclined edges, delaminations or (adhesive) joints. For these cases, only the thickness direction of the structure needs to be discretized at several locations, while the direction of propagation is described analytically. Consequently, the number of degrees of freedom is very small. Semi-infinite domains can be modeled, in which case the radiation condition is fulfilled exactly...
August 1, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28800447/two-phase-displacements-in-microchannels-of-triangular-cross-section
#10
Yafei Liu, Andrew Hansen, Erica Block, Norman R Morrow, Jeff Squier, John Oakey
Varying microfluidic channel cross-sectional geometry can dramatically alter fluid flow behavior, particularly for capillary-driven flow. Most fabrication techniques, however, are planar and therefore incapable of providing depth-dependent variations in width. We introduce an ultrafast laser ablation technique that enables the fabrication of microchannels with arbitrary triangular cross sectional geometry. Triangular channels were fabricated with widths ranging from 45 to 116µm and aspect ratios between 0...
August 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28799994/lower-extremity-deformity-management-in-amyoplasia-when-and-how
#11
Kit Song
This article presents an approach to the musculoskeletal problems of children with amyoplasia. Although a very high percentage of children with have ambulatory potential, activity and function decline over time. Strong consideration of external resources and support available to the child and family are important considerations in recommending surgery as is the timing of interventions to align with childhood development.
September 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28797788/novel-dehydroabietylamine-derivatives-as-potent-inhibitors-of-acetylcholinesterase
#12
Jana Wiemann, Anne Loesche, René Csuk
Nowadays, the inhibition of acetylcholinesterase is one of the main pharmacological strategies for the treatment of Alzheimer's disease. Therefore, a set of thirty-four derivatives of the diterpenoid dehydroabietylamine has been synthesized and screened in colorimetric Ellman's assays to determine their ability to inhibit the enzymes acetylcholinesterase (AChE, from electric eel) and butyrylcholinesterase (BChE, from equine serum). A systematic variation of the substitution of dehydroabietylamides enabled an approach to analogs showing a remarkable inhibition potency for AChE...
August 1, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28794621/counseling-for-health-behavior-change-in-people-with-copd-systematic-review
#13
REVIEW
Marie T Williams, Tanja W Effing, Catherine Paquet, Carole A Gibbs, Hayley Lewthwaite, Lok Sze Katrina Li, Anna C Phillips, Kylie N Johnston
Counseling has been suggested as a promising approach for facilitating changes in health behavior. The aim of this systematic review of counseling interventions for people with COPD was to describe: 1) counseling definitions, 2) targeted health behaviors, 3) counseling techniques and 4) whether commonalities in counseling techniques were associated with improved health behaviors. Ten databases were searched for original randomized controlled trials which included adults with COPD, used the term "counseling" as a sole or component of a multifaceted intervention and were published in the previous 10 years...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28794285/preventing-chemotherapy-induced-myelosuppression-by-repurposing-the-flt3-inhibitor-quizartinib
#14
Samuel J Taylor, Johanna M Duyvestyn, Samantha A Dagger, Emma J Dishington, Catherine A Rinaldi, Oliver M Dovey, George S Vassiliou, Carolyn S Grove, Wallace Y Langdon
We describe an approach to inhibit chemotherapy-induced myelosuppression. We found that short-term exposure of mice to the FLT3 inhibitor quizartinib induced the transient quiescence of multipotent progenitors (MPPs). This property of quizartinib conferred marked protection to MPPs in mice receiving fluorouracil or gemcitabine. The protection resulted in the rapid recovery of bone marrow and blood cellularity, thus preventing otherwise lethal myelosuppression. A treatment strategy involving quizartinib priming that protected wild-type bone marrow progenitors, but not leukemic cells, from fluorouracil provided a more effective treatment than conventional induction therapy in mouse models of acute myeloid leukemia...
August 9, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28794150/peripheral-neuropathy-in-complex-inherited-diseases-an-approach-to-diagnosis
#15
REVIEW
Alexander M Rossor, Aisling S Carr, Helen Devine, Hoskote Chandrashekar, Ana Lara Pelayo-Negro, Davide Pareyson, Michael E Shy, Steven S Scherer, Mary M Reilly
Peripheral neuropathy is a common finding in patients with complex inherited neurological diseases and may be subclinical or a major component of the phenotype. This review aims to provide a clinical approach to the diagnosis of this complex group of patients by addressing key questions including the predominant neurological syndrome associated with the neuropathy, for example, spasticity, the type of neuropathy and the other neurological and non-neurological features of the syndrome. Priority is given to the diagnosis of treatable conditions...
August 9, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28793855/contrasting-morphology-with-molecular-data-an-approach-to-revision-of-species-complexes-based-on-the-example-of-european-phoxinus-cyprinidae
#16
Anja Palandačić, Alexander Naseka, David Ramler, Harald Ahnelt
BACKGROUND: Molecular taxonomy studies and barcoding projects can provide rapid means of detecting cryptic diversity. Nevertheless, the use of molecular data for species delimitation should be undertaken with caution. Especially the single-gene approaches are linked with certain pitfalls for taxonomical inference. In the present study, recent and historical species descriptions based upon morphology were used as primary species hypotheses, which were then evaluated with molecular data (including in type and historical museum material) to form secondary species hypotheses...
August 9, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28793321/effects-of-combination-treatment-with-alendronate-and-raloxifene-on-skeletal-properties-in-a-beagle-dog-model
#17
Matthew R Allen, Erin McNerny, Mohammad Aref, Jason M Organ, Christopher L Newman, Brian McGowan, Tim Jang, David B Burr, Drew M Brown, Max Hammond, Paul R Territo, Chen Lin, Scott Persohn, Lei Jiang, Amanda A Riley, Brian P McCarthy, Gary D Hutchins, Joseph M Wallace
A growing number of studies have investigated combination treatment as an approach to treat bone disease. The goal of this study was to investigate the combination of alendronate and raloxifene with a particular focus on mechanical properties. To achieve this goal we utilized a large animal model, the beagle dog, used previously by our laboratory to study both alendronate and raloxifene monotherapies. Forty-eight skeletally mature female beagles (1-2 years old) received daily oral treatment: saline vehicle (VEH), alendronate (ALN), raloxifene (RAL) or both ALN and RAL...
2017: PloS One
https://www.readbyqxmd.com/read/28792767/photon-reabsorption-masks-intrinsic-bimolecular-charge-carrier-recombination-in-ch3nh3pbi3-perovskite
#18
Timothy W Crothers, Rebecca L Milot, Jay B Patel, Elizabeth S Parrott, Johannes Schlipf, Peter Müller-Buschbaum, Michael B Johnston, Laura M Herz
An understanding of charge-carrier recombination processes is essential for the development of hybrid metal halide perovskites for photovoltaic applications. We show that typical measurements of the radiative bimolecular recombination constant in CH3NH3PbI3 are strongly affected by photon reabsorption that masks a much larger intrinsic bimolecular recombination rate constant. By investigating a set of films whose thickness varies between 50 and 533 nm, we find that the bimolecular charge recombination rate appears to slow by an order of magnitude as the film thickness increases...
August 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28790117/in-vivo-validation-of-papss1-3-phosphoadenosine-5-phosphosulfate-synthase-1-as-a-cisplatin-sensitizing-therapeutic-target
#19
Ada W Y Leung, Chansey J Veinotte, Nicole Melong, Min Hee Oh, Kent T J Chen, Katey Enfield, Ian Backstrom, Corinna Warburton, Donald T Yapp, Jason N Berman, Marcel B Bally, William W Lockwood
INTRODUCTION: Our previous screening efforts found that inhibition of PAPSS1 increases the potency of DNA damaging agents in non-small cell lung cancer (NSCLC) cell lines. Here, we explored the clinical relevance of PAPSS1 and further investigated it as a therapeutic target in pre-clinical model systems. METHODS: PAPSS1 expression and cisplatin IC50 values were assessed in 52 lung adenocarcinoma (LAC) cell lines. Effects of PAPSS1 inhibition on A549 cisplatin sensitivity under hypoxic and starvation conditions, in 3D spheroids, as well as in zebrafish and mouse xenografts, were evaluated...
August 8, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28790017/detecting-pathway-relationship-in-the-context-of-human-protein-protein-interaction-network-and-its-application-to-parkinson-s-disease
#20
Ying Hu, Yichen Yang, Zhonghai Fang, Yan-Shi Hu, Lei Zhang, Ju Wang
In human physiological conditions like complex diseases, a large number of genes/proteins, as well as their interactions, are involved. Thus, detecting the biochemical pathways enriched in these genes/proteins and identifying the pathway relationships is critical to understand the molecular mechanisms underlying a disease and can also be valuable in selecting the potential molecular targets for further exploration. In this study, we proposed a method to measure the relationship between pathways based on their distribution in the human PPI network...
August 5, 2017: Methods: a Companion to Methods in Enzymology
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