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https://www.readbyqxmd.com/read/29334338/at-home-genital-nerve-stimulation-for-individuals-with-sci-and-neurogenic-detrusor-overactivity-a-pilot-feasibility-study
#1
Dennis J Bourbeau, Kenneth J Gustafson, Steven W Brose
OBJECTIVE: Neurogenic bladder dysfunction, including neurogenic detrusor overactivity (NDO) is one of the most clinically significant problems for persons with spinal cord injury (SCI), affecting health and quality of life. Genital nerve stimulation (GNS) can acutely inhibit NDO-related reflex bladder contractions and increase bladder capacity. However, it is unknown if GNS can improve urinary continence or help meet individuals' bladder management goals during sustained use, which is required for GNS to be clinically effective...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29333924/dynamic-mr-imaging-for-functional-vascularization-depends-on-tissue-factor-signaling-in-glioblastoma
#2
Xiao Chen, Tian Xie, Jingqin Fang, Wei Xue, Houyi Kang, Haipeng Tong, Yu Guo, Bo Zhang, Sumei Wang, Yizeng Yang, Weiguo Zhang
Glomeruloid vascular proliferation (GVP) is a diagnostic hallmark and links to aggressive behavior, therapy resistance and poor prognosis in glioblastoma (GBM). It lacks clinical approaches to predict and monitor its formation and dynamic change. Yet the mechanism of GVPs also remains largely unknown. Using an in situ GBM xenograft mouse model, combined clinical MRI images of pre-surgery tumor and pathological investigation, we demonstrated that the inhibition of tissue factor (TF) decreased GVPs in Mouse GBM xenograft model...
January 15, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29331599/long-term-reduction-of-seclusion-and-forced-medication-on-a-hospital-wide-level-implementation-of-an-open-door-policy-over-6-years
#3
L Hochstrasser, D Fröhlich, A R Schneeberger, S Borgwardt, U E Lang, R-D Stieglitz, C G Huber
BACKGROUND: Psychiatric inpatient treatment is increasingly performed in settings with locked doors. However, locked wards have well-known disadvantages and are ethically problematic. In addition, recent data challenges the hypothesis that locked wards provide improved safety over open-door settings regarding suicide, absconding and aggression. Furthermore, there is evidence that the introduction of an open-door policy may lead to short-term reductions in involuntary measures. The aim of this study was to assess if the introduction of an open-door policy is associated with a long-term reduction of the frequency of seclusion and forced medication...
December 11, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29331449/quantifying-axonal-responses-in-patient-specific-models-of-subthalamic-deep-brain-stimulation
#4
Kabilar Gunalan, Bryan Howell, Cameron C McIntyre
Medical imaging has played a major role in defining the general anatomical targets for deep brain stimulation (DBS) therapies. However, specifics on the underlying brain circuitry that is directly modulated by DBS electric fields remain relatively undefined. Detailed biophysical modeling of DBS provides an approach to quantify the theoretical responses to stimulation at the cellular level, and has established a key role for axonal activation in the therapeutic mechanisms of DBS. Estimates of DBS-induced axonal activation can then be coupled with advances in defining the structural connectome of the human brain to provide insight into the modulated brain circuitry and possible correlations with clinical outcomes...
January 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29329024/-teamup-an-approach-to-developing-teamwork-skills-in-undergraduate-midwifery-students
#5
Carolyn Ruth Hastie
OBJECTIVE: to develop an effective model to enable educators to teach, develop and assess the development of midwifery students' teamwork skills DESIGN: an action research project involving participant interviews and academic feedback. SETTING: a regional university PARTICIPANTS: midwifery students (n = 21) and new graduate midwives (n = 20) INTERVENTIONS: a whole of course program using a rubric, with five teamwork domains and behavioural descriptors, to provide a framework for teaching and assessment...
December 28, 2017: Midwifery
https://www.readbyqxmd.com/read/29328274/photonics-enabled-compressive-sensing-with-spectral-encoding-using-an-incoherent-broadband-source
#6
Zhijing Zhu, Hao Chi, Tao Jin, Shilie Zheng, Xianbin Yu, Xiaofeng Jin, Xianmin Zhang
In this Letter, we propose an approach to achieving photonics-enabled compressive sensing of sparse wideband radio frequency signals in which an incoherent broadband source is applied, and the mixing and integration functions are realized in the optical domain. A spectrum shaper is employed to slice and encode the spectrum of the broadband light according to a predetermined random sequence. Because of the dispersion-induced group delay, the mixing between the incoming signal and the random bit sequence is achieved...
January 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29325233/catatonia-an-approach-to-diagnosis-and-treatment
#7
James K Rustad, H Samuel Landsman, Ana Ivkovic, Christine T Finn, Theodore A Stern
No abstract text is available yet for this article.
January 4, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29323416/citizenship-and-community-mental-health-care
#8
Allison N Ponce, Michael Rowe
Citizenship is an approach to supporting the social inclusion and participation in society of people with mental illnesses. It is receiving greater attention in community mental health discourse and literature in parallel with increased awareness of social determinants of health and concern over the continued marginalization of persons with mental illness in the United States. In this article, we review the definition and principles of our citizenship framework with attention to social participation and access to resources as well as rights and responsibilities that society confers on its members...
January 11, 2018: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29322276/integrating-direct-observation-and-gps-tracking-to-monitor-animal-behavior-for-resource-management
#9
Chelsey Walden-Schreiner, Yu-Fai Leung, Tim Kuhn, Todd Newburger
Monitoring the behavior of pack animals in protected areas informs management about use patterns and the potential associated negative impacts. However, systematic assessments of behavior are uncommon due to methodological and logistical constraints. This study integrated behavior mapping with GPS tracking, and applied behavior change point analysis, as an approach to monitor the behaviors of pack animals during overnight periods. The integrated approach identified multiple grazing patterns (i.e., locally intense grazing, ambulatory grazing) not feasible through a single methodology alone...
January 10, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29321613/evaluation-of-in-vivo-digital-root-reconstruction-based-on-anatomical-characteristics-of-the-periodontal-ligament-using-cone-beam-computed-tomography
#10
Chenxin Wang, Yi Liu, Siwei Wang, Yong Wang, Yijiao Zhao
This study's aim was to develop and validate an approach to automatically extract and reconstruct three-dimensional (3D) digital root models from in vivo teeth based on the anatomical characteristics of the periodontal ligament using cone beam computed tomography (CBCT) data. Prior to undergoing dental extractions for orthodontic purposes, the CBCT data of each study participant were collected and imported into Mimics software to reconstruct 3D in vivo digital root models (test models). Twenty roots of 17 teeth extracted from the study's participants were scanned using a dental scanner to obtain 3D in vitro digital root models (reference models)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321572/specific-inhibition-of-acetylcholinesterase-as-an-approach-to-decrease-muscarinic-side-effects-during-myasthenia-gravis-treatment
#11
Konstantin A Petrov, Alexandra D Kharlamova, Oksana A Lenina, Ayrat R Nurtdinov, Marina E Sitdykova, Victor I Ilyin, Irina V Zueva, Evgeny E Nikolsky
Non-selective inhibitors of cholinesterases (ChEs) are clinically used for treatment of myasthenia gravis (MG). While being generally safe, they cause numerous adverse effects including induction of hyperactivity of urinary bladder and intestines affecting quality of patients life. In this study we have compared two ChEs inhibitors, a newly synthesized compound C547 and clinically used pyridostigmine bromide, by their efficiency to reduce muscle weakness symptoms and ability to activate contractions of urinary bladder in a rat model of autoimmune MG...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320526/temporal-and-spectral-characteristics-of-dynamic-functional-connectivity-between-resting-state-networks-reveal-information-beyond-static-connectivity
#12
Sharon Chiang, Emilian R Vankov, Hsiang J Yeh, Michele Guindani, Marina Vannucci, Zulfi Haneef, John M Stern
Estimation of functional connectivity (FC) has become an increasingly powerful tool for investigating healthy and abnormal brain function. Static connectivity, in particular, has played a large part in guiding conclusions from the majority of resting-state functional MRI studies. However, accumulating evidence points to the presence of temporal fluctuations in FC, leading to increasing interest in estimating FC as a dynamic quantity. One central issue that has arisen in this new view of connectivity is the dramatic increase in complexity caused by dynamic functional connectivity (dFC) estimation...
2018: PloS One
https://www.readbyqxmd.com/read/29318550/assessing-the-influence-of-a%C3%A2-protease-in-cell-migration-using-the-barrier-migration-assay
#13
Tania Fontanil, Yamina Mohamedi, Santiago Cal, Álvaro J Obaya
Proteases play crucial roles in all steps of tumor progression including cancer cell migration. In fact, uncontrolled proteolytic activity could lead to the degradation of different components of the extracellular matrix which facilitates dissemination of tumor cells. However, numerous studies have revealed that proteases may also exert tumor-protective actions which could impede progression of malignant cells. Consequently, it is crucial to distinguish those situations in which proteases promote tumor growth from those in which exhibit tumor-suppressive effects...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29318443/standardized-effect-sizes-for-preventive-mobile-health-interventions-in-micro-randomized-trials
#14
Brook Luers, Predrag Klasnja, Susan Murphy
Mobile Health (mHealth) interventions are behavioral interventions that are accessible to individuals in their daily lives via a mobile device. Most mHealth interventions consist of multiple intervention components. Some of the components are "pull" components, which require individuals to access the component on their mobile device at moments when they decide they need help. Other intervention components are "push" components, which are initiated by the intervention, not the individual, and are delivered via notifications or text messages...
January 9, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29316944/car-t-cells-targeting-cll-1-as-an-approach-to-treat-acute-myeloid-leukemia
#15
Jinghua Wang, Siyu Chen, Wei Xiao, Wende Li, Liang Wang, Shuo Yang, Weida Wang, Liping Xu, Shuangye Liao, Wenjian Liu, Yang Wang, Nawei Liu, Jianeng Zhang, Xiaojun Xia, Tiebang Kang, Gong Chen, Xiuyu Cai, Han Yang, Xing Zhang, Yue Lu, Penghui Zhou
BACKGROUND: Acute myeloid leukemia (AML) is one of the most common types of adult acute leukemia. Standard chemotherapies can induce complete remission in selected patients; however, a majority of patients eventually relapse and succumb to the disease. Thus, the development of novel therapeutics for AML is urgently needed. Human C-type lectin-like molecule-1 (CLL-1) is a type II transmembrane glycoprotein, and its expression is restricted to myeloid cells and the majority of AML blasts...
January 10, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29316792/maximal-predictability-approach-for-identifying-the-right-descriptors-for-electrocatalytic-reactions
#16
Dilip Krishnamurthy, Vaidish Sumaria, Venkatasubramanian Viswanathan
Density Functional Theory (DFT) calculations are being routinely used to iden- tify new material candidates that approach activity near fundamental limits imposed by thermodynamics or scaling relations. DFT calculations are associated with inher- ent uncertainty, which limits the ability to delineate materials (distinguishability) that possess high activity. Development of error-estimation capabilities in DFT has en- abled uncertainty propagation through activity-prediction models. In this work, we demonstrate an approach to propagating uncertainty through thermodynamic activ- ity models leading to a probability distribution of the computed activity and thereby its expectation value...
January 10, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29316500/temperature-dependent-cellulase-adsorption-on-lignin-from-sugarcane-bagasse
#17
Ariane Zanchetta, Antonio Carlos Freitas Dos Santos, Eduardo Ximenes, Christiane da Costa Carreira Nunes, Maurício Boscolo, Eleni Gomes, Michael R Ladisch
Extents of adsorption of cellulolytic enzymes on lignin, derived from sugarcane bagasse, were an inverse function of incubation temperature and varied with type of lignin extraction. At 45 °C, lignin derived from acid hydrolyzed liquid hot water pretreated bagasse completely adsorbed cellulolytic enzymes from Trichoderma reesei within 90 min. Lignin derived from enzyme hydrolyzed liquid hot water pretreated bagasse adsorbed only 60% of T. reesei endoglucanase, exoglucanase and β-glucosidase activities...
December 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29316002/multidisciplinary-perspectives-application-of-the-consolidated-framework-for-implementation-research-to-evaluate-a-health-coaching-initiative
#18
Judy Brook, Caroline McGraw
Long-term conditions are a leading cause of mortality and morbidity. Their management is founded on a combination of approaches involving government policy, better integration between health and care systems, and individual responsibility for self-care. Health coaching has emerged as an approach to encouraging individual responsibility and enhancing the self-management of long-term conditions. This paper focuses on the evaluation of a workforce initiative in a diverse and socially deprived community. The initiative sought both to improve integration between health and care services for people with long-term conditions, and equip practitioners with health coaching skills...
January 7, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29314275/an-approach-to-the-asthma-protective-farm-effect-by-geocoding-good-farms-and-better-farms
#19
Susanne E K Müller-Rompa, Iana Markevych, Alexander J Hose, Georg Loss, Inge M Wouters, Jon Genuneit, Charlotte Braun-Fahrländer, Elisabeth Horak, Andrzej Boznanski, Dick Heederik, Erika von Mutius, Joachim Heinrich, Markus J Ege
BACKGROUND: The highly consistent association of growing up on a farm with a reduced asthma risk has so far been attributed to direct farm exposure. In contrast, geographical determinants of the larger environment have never been assessed. In this study, the effects of proximity to farms and environmental variables in relation to the residential address on asthma and atopy were assessed. METHODS: Addresses of 2,265 children of the Bavarian arm of the GABRIELA-study were converted into geocodes...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29310273/identification-and-classification-of-cathinone-unknowns-by-statistical-analysis-processing-of-direct-analysis-in-real-time-high-resolution-mass-spectrometry-derived-neutral-loss-spectra
#20
Kristen L Fowble, Jason R E Shepard, Rabi A Musah
An approach to the rapid determination of the structures of novel synthetic cathinone designer drugs, also known as bath salts, is reported. While cathinones fragment so extensively by electron impact mass spectrometry that their mass spectra often cannot be used to identify the structure, collision-induced dissociation (CID) direct analysis in real time-high resolution mass spectrometry (DART-HRMS) experiments furnished spectra that provided diagnostic fragmentation patterns for the analyzed cathinones. From this data, neutral loss spectra, which reflect the presence of specific chemical moieties, could be acquired...
March 1, 2018: Talanta
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